Digital Commons Network^™

Relationship Between Congestive Heart Failure, Chronic Obstructive Pulmonary Disease, Inflammatory Biomarkers, And Hospital Length Of Stay Among Covid-19 Patients., Alice Aghamie Osuji

Walden Dissertations and Doctoral Studies

COVID-19 has put immense pressure on healthcare facilities, especially in managing patients with comorbidity. This study addressed the association between two important coinfections, congestive heart failure (CHF) and chronic obstructive pulmonary disease (COPD), and their effect on hospital length of stay (LOS) among COVID-19 patients. The study also explored the predictive role of the inflammatory biomarker C-reactive protein (CRP) in prolonged hospitalization, also considering the influence of age and race. This study applied the Biopsychosocial Model and Chronic Care Model (CCM) to examine health outcomes and resource use. A retrospective cohort research design was used to examine medical records of …

Characterization Of Long-Noncoding Rnas In Prostate And Pancreatic Cancer Through Single Cell Transcriptomics, Debanjan Saha

Arts & Sciences Graduate Student Theses and Dissertations

Metastatic castration resistant prostate cancer (mCRPC) is a subtype of prostate cancer that develops after metastasis and resistance to hormone therapy, thereby carrying a poor prognosis. Likewise, pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies due to its propensity to present at advanced, unresectable stages in patients. Recent genomic studies have identified molecular features of mCRPC and PDAC, such as the existence of mutations in key driver genes, the extensive transcriptomic intra-tumoral heterogeneity, the role of regulatory elements in dictating driver gene expression, mechanisms of treatment resistance, and the interactions with the immunosuppressive and stromal tumor- microenvironment …

Large-Scale Multi-Omics Analyses In Hispanic/Latino Populations Identify Genes For Cardiometabolic Traits, Lauren E Petty, Hung-Hsin Chen, Elizabeth G Frankel, Wanying Zhu, Carolina G Downie, Mariaelisa Graff, Phillip Lin, Priya Sharma, Xinruo Zhang, Alyssa C Scartozzi, Rashedeh Roshani, Joshua M Landman, Michael Boehnke, Donald W Bowden, John C Chambers, Anubha Mahajan, Mark I Mccarthy, Maggie C Y Ng, Xueling Sim, Cassandra N Spracklen, Weihua Zhang, Michael Preuss, Erwin P Bottinger, Girish N Nadkarni, Ruth J F Loos, Yii-Der Ida Chen, Jingyi Tan, Eli Ipp, Pauline Genter, Leslie S Emery, Tin Louie, Tamar Sofer, Adrienne M Stilp, Kent D Taylor, Anny H Xiang, Thomas A Buchanan, Kathryn Roll, Chuan Gao, Nicholette D Palmer, Jill M Norris, Lynne E Wagenknecht, Darryl Nousome, Rohit Varma, Roberta Mckean-Cowdin, Xiuqing Guo, Yang Hai, Willa Hsueh, Kevin Sandow, Esteban J Parra, Miguel Cruz, Adan Valladares-Salgado, Niels Wacher-Rodarte, Jerome I Rotter, Mark O Goodarzi, Stephen S Rich, Alain Bertoni, Leslie J Raffel, Jerry L Nadler, Fouad R Kandeel, Ravindranath Duggirala, John Blangero, Donna M Lehman, Ralph A Defronzo, Farook Thameem, Yujie Wang, Sheila Gahagan, Estela Blanco, Raquel Burrows, Alicia Huerta-Chagoya, Jose C Florez, Teresa Tusie-Luna, Clicerio González-Villalpando, Lorena Orozco, Christopher A Haiman, Craig L Hanis, Rebecca Rohde, Eric A Whitsel, Alexander P Reiner, Charles Kooperberg, Yun Li, Qing Duan, Miryoung Lee, Paulina Correa-Burrows, Susan K Fried, Kari E North, Joseph B Mccormick, Susan P Fisher-Hoch, Eric R Gamazon, Andrew P Morris, Josep M Mercader, Heather M Highland, Jennifer E Below

Faculty, Staff and Student Publications

Here, we present a multi-omics study of type 2 diabetes and quantitative blood lipid and lipoprotein traits conducted to date in Hispanic/Latino populations (nmax = 63,184). We conduct a meta-analysis of 16 type 2 diabetes and 19 lipid trait GWAS, identifying 20 genome-wide significant loci for type 2 diabetes, including one novel locus and novel signals at two known loci, based on fine-mapping. We also identify sixty-one genome-wide significant loci across the lipid/lipoprotein traits, including nine novel loci, and novel signals at 19 known loci through fine-mapping. Next, we analyze genetically regulated expression, perform Mendelian randomization, and analyze association with …

Impacts Of Riverine Heatwaves On Rates Of Ecosystem Metabolism In The United States, Spencer J. Tassone, Michelle Kelly, Olivia N. Beidler, Michael L. Pace, Amy Marcarelli

Michigan Tech Publications

Rivers produce and decompose large amounts of carbon globally due, in part, to high rates of gross primary production (GPP) and ecosystem respiration (ER), collectively known as ecosystem metabolism. Water temperature is a major driver of ecosystem metabolism, and in-stream temperatures are increasing globally, including extreme temperature events called heatwaves. This study used published estimates of daily GPP and ER from 48 stream and river locations in the United States to examine how ecosystem metabolism responds to riverine heatwaves. During low-severity heatwaves, GPP and ER increase proportionally, resulting in no net difference. However, during severe and extreme heatwaves, GPP declined …

Whole Genome Sequencing Analysis Of Body Mass Index Identifies Novel African Ancestry-Specific Risk Allele, Xinruo Zhang, Jennifer A Brody, Mariaelisa Graff, Heather M Highland, Nathalie Chami, Hanfei Xu, Zhe Wang, Kendra R Ferrier, Geetha Chittoor, Navya Shilpa Josyula, Mariah Meyer, Shreyash Gupta, Xihao Li, Zilin Li, Matthew A Allison, Diane M Becker, Lawrence F Bielak, Joshua C Bis, Meher Preethi Boorgula, Donald W Bowden, Jai G Broome, Erin J Buth, Christopher S Carlson, Kyong-Mi Chang, Sameer Chavan, Yen-Feng Chiu, Lee-Ming Chuang, Matthew P Conomos, Dawn L Demeo, Mengmeng Du, Ravindranath Duggirala, Celeste Eng, Alison E Fohner, Barry I Freedman, Melanie E Garrett, Xiuqing Guo, Chris Haiman, Benjamin D Heavner, Bertha Hidalgo, James E Hixson, Yuk-Lam Ho, Brian D Hobbs, Donglei Hu, Qin Hui, Chii-Min Hwu, Rebecca D Jackson, Deepti Jain, Rita R Kalyani, Sharon L R Kardia, Tanika N Kelly, Ethan M Lange, Michael Lenoir, Changwei Li, Loic Le Marchand, Merry-Lynn N Mcdonald, Caitlin P Mchugh, Alanna C Morrison, Take Naseri, Jeffrey O'Connell, Christopher J O'Donnell, Nicholette D Palmer, James S Pankow, James A Perry, Ulrike Peters, Michael H Preuss, D C Rao, Elizabeth A Regan, Sefuiva M Reupena, Dan M Roden, Jose Rodriguez-Santana, Colleen M Sitlani, Jennifer A Smith, Hemant K Tiwari, Ramachandran S Vasan, Zeyuan Wang, Daniel E Weeks, Jennifer Wessel, Kerri L Wiggins, Lynne R Wilkens, Peter W F Wilson, Lisa R Yanek, Zachary T Yoneda, Wei Zhao, Sebastian Zöllner, Donna K Arnett, Allison E Ashley-Koch, Kathleen C Barnes, John Blangero, Eric Boerwinkle, Esteban G Burchard, April P Carson, Daniel I Chasman, Yii-Der Ida Chen, Joanne E Curran, Myriam Fornage, Victor R Gordeuk, Jiang He, Susan R Heckbert, Lifang Hou, Marguerite R Irvin, Charles Kooperberg, Ryan L Minster, Braxton D Mitchell, Mehdi Nouraie, Bruce M Psaty, Laura M Raffield, Alexander P Reiner, Stephen S Rich, Jerome I Rotter, M Benjamin Shoemaker, Nicholas L Smith, Kent D Taylor, Marilyn J Telen, Scott T Weiss, Yingze Zhang, Nancy Heard-Costa, Yan V Sun, Xihong Lin, L Adrienne Cupples, Leslie A Lange, Ching-Ti Liu, Ruth J F Loos, Kari E North, Anne E Justice

Faculty, Staff and Student Publications

Obesity is a major public health crisis associated with high mortality rates. Previous genome-wide association studies (GWAS) investigating body mass index (BMI) have largely relied on imputed data from European individuals. This study leveraged whole-genome sequencing (WGS) data from 88,873 participants from the Trans-Omics for Precision Medicine (TOPMed) Program, of which 51% were of non-European population groups. We discovered 18 BMI-associated signals (P <  5 × 10

Vasoactive Selection For Pediatric Septic Shock-Where To Begin?, Scott L. Weiss

Department of Pediatrics Faculty Papers

No abstract provided.

Fulltime Faculty Perspectives On Engagement In Distributed Leadership At A Technical College, Jacinda Halene Lay

Walden Dissertations and Doctoral Studies

The problem that was addressed in this basic qualitative study was that fulltime college faculty was not sufficiently engaged in distributed leadership at a technical college in a western state. The purpose of this study was to explore fulltime college faculty members’ perspective about their engagement in distributed leadership at a technical college in a western state. The research questions explored how fulltime faculty described their engagement in, and knowledge of, faculty leadership, at a technical college, and recommendations for increasing engagement. Using Spillane’s leader plus paradigm as the conceptual framework, semistructured interviews of 14 purposively sampled fulltime college faculty …

Plasmonic Sensor Nata De Coco Film Inserted With Copper Nanoparticles For Detection Of Mercury By Uv-Vis Spectrophotometry, Abdul Haris Haris Watoni, Rijal Rijal, La Ode Ahmad Nur Ramadhan, La Ode Abdul Kadir

Chimica et Natura Acta

The rapid development of the mining industry has resulted in an increasing amount of toxic waste materials in the environment, including mercury (Hg). A reliable chemical sensor is needed to detect the presence of mercury. One of the chemical sensors that is starting to be widely developed is plasmonic film. This research aims to determine the characteristics and validity of plasmonic nata de coco-copper nanoparticle (CuNPs) films for cuvette type sensor chips in the rapid detection of Hg metal using UV-Vis spectrophotometry. This research began with the preparation of a bioreductor from red dragon fruit peel extract, green synthesis of …

Local Nutrient Addition Drives Plant Diversity Losses But Not Biotic Homogenization In Global Grasslands, Qingqing Chen, Shane A. Blowes, W. Stanley Harpole, Emma Ladouceur, Elizabeth T. Borer, Andrew Macdougall, Erika Hersch-Green, Et Al.

Michigan Tech Publications

Nutrient enrichment typically causes local plant diversity declines. A common but untested expectation is that nutrient enrichment also reduces variation in nutrient conditions among localities and selects for a smaller pool of species, causing greater diversity declines at larger than local scales and thus biotic homogenization. Here we apply a framework that links changes in species richness across scales to changes in the numbers of spatially restricted and widespread species for a standardized nutrient addition experiment across 72 grasslands on six continents. Overall, we find proportionally similar species loss at local and larger scales, suggesting similar declines of spatially restricted …

Natural Killer Cells’ Functional Impairment Drives The Immune Escape Of Pre-Malignant Clones In Early-Stage Myelodysplastic Syndromes, Juan Jose Rodriguez-Sevilla, Irene Ganan-Gomez, Bijender Kumar, Natthakan Thongon, Feiyang Ma, Kelly S Chien, Yi J Kim, Hui Yang, Sanam Loghavi, Roselyn Tan, Vera Adema, Zongrui Li, Tomoyuki Tanaka, Hidetaka Uryu, Rashmi Kanagal-Shamanna, Gheath Al-Atrash, Rafael Bejar, Pinaki Prosad Banerjee, Sophia Lynn Cha, Guillermo Montalban-Bravo, Max Dougherty, Maria Claudina Fernandez Laurita, Noelle Wheeler, Baosen Jia, Eirini P Papapetrou, Franco Izzo, Daniela E Dueñas, Salome Mcallen, Yiqian Gu, Gabriele Todisco, Francesca Ficara, Matteo Giovanni Della Porta, Abhinav Jain, Koichi Takahashi, Karen Clise-Dwyer, Stephanie Halene, Maria Teresa Sabrina Bertilaccio, Guillermo Garcia-Manero, May Daher, Simona Colla

Faculty, Staff and Student Publications

Dissecting the preneoplastic disease states' biological mechanisms that precede tumorigenesis can lead to interventions that can slow down disease progression and/or mitigate disease-related comorbidities. Myelodysplastic syndromes (MDS) cannot be cured by currently available pharmacological therapies, which fail to eradicate aberrant hematopoietic stem cells (HSCs), most of which are mutated by the time of diagnosis. Here, we sought to elucidate how MDS HSCs evade immune surveillance and expand in patients with clonal cytopenias of undetermined significance (CCUS), the pre-malignant stage of MDS. We used multi-omic single-cell approaches and functional in vitro studies to show that immune escape at disease initiation is …

The Role Of Cholinergic Ventral Pallidum Cells In Effortful Motivation, Elizabeth A. Bien

Dartmouth College Ph.D Dissertations

Maladaptive reward-seeking behavior can be driven by one of several different components including excessive craving elicited by cues that predict rewards, failing to effortfully pursue rewards when it is beneficial to do so, and compulsively seeking rewards when it is no longer advantageous to do so. This thesis includes experiments focusing on these three different components of reward-seeking behavior to better understand how reward-seeking can become maladaptive. First, we wanted to examine the role that sex plays in the acquisition and compulsiveness of sign-tracking behavior in the Long Evans rat, a strain that is commonly used as the background for …

Histone H3 Cysteine 110 Enhances Iron Metabolism And Modulates Replicative Life Span In Saccharomyces Cerevisiae, Chen Cheng, Brenna S Mccauley, Nedas Matulionis, Maria Vogelauer, Dimitrios Camacho, Heather R Christofk, Weiwei Dang, Nicholas A T Irwin, Siavash K Kurdistani

Center on Aging Staff Publications

The discovery of histone H3 copper reductase activity provides a novel metabolic framework for understanding the functions of core histone residues, which, unlike N-terminal residues, have remained largely unexplored. We previously demonstrated that histone H3 cysteine 110 (H3C110) contributes to cupric (Cu2+) ion binding and its reduction to the cuprous (Cu1+) form. However, this residue is absent in Saccharomyces cerevisiae, raising questions about its evolutionary and functional significance. Here, we report that H3C110 has been lost in many fungal lineages despite near-universal conservation across eukaryotes. Introduction of H3C110 into S. cerevisiae increased intracellular Cu1+ levels and ameliorated the iron …

Facilitating Women's Success In Software Engineering Through The Exploration Of Non-Traditional Educational Environments, Fiya Clerget, Chanel Davis, Taylor Hobbs

Discovery Day - Prescott

STEM fields face persistent challenges with diversity, equity, and inclusion. For example, while women make up 56% of students enrolled in undergraduate degrees, women account for only 22% of the students in engineering programs. This number drops even further in the workforce, where women comprise only 15.9% of the engineering industry (US Bureau of Labor Statistics, 2024). Consequently, the industry of equity-focused coding education has grown rapidly, leading to the rise of coding boot camps, workshops, and community-based coding education specifically designed to increase the participation of women and underrepresented programmers in tech (Rea, 2022; Jabbari, 2023). While the impacts …

2025 Silent Bell Recipient: Richard W. Panek, Dds

West Michigan District Dental Society Bulletin

The West Michigan District Dental Society’s highest award is the Distinguished Service Award. This award, also known as the “Silent Bell,” is given to recognize contributions to organized dentistry. These contributions include service to dental professionals, patients, and the community.

Dr. Richard Walter Panek, a devoted oral surgeon and community leader, is honored with the 2025 Silent Bell Award. His life reflects compassion, practicality, and service, shaped by his Polish roots, faith, and deep commitment to family, dentistry, and the broader West Michigan community.

Wmdds Bulletin Winter 2025

West Michigan District Dental Society Bulletin

In the Winter 2025 issue, the reader will find the following articles:

• 2025 Silent Bell Recipient: Richard W. Panek, DDS, as well as Silent Bell Night Celebration Highlights and a list of Past Recipients

• Dentists Beyond the Chair: Caitlynn Haas DDS, Holland, MI

Also included are your monthly tripartite update, news from West Michigan counties, the President's Message and Editor's Letter.

Intersectional Experiences Of Stem Students With Disabilities, Sandy Heath, Jade Metzger, Tarah Loy-Ashe

Journal of Science Education for Students with Disabilities

Students with disabilities experience barriers to accessing Science, Technology, Engineering, and Mathematics (STEM) careers during academic preparation for these careers. This pilot project explored the experiences of postsecondary STEM students who have a disability. The six students interviewed gave their insights into the need to further diversify who has access to STEM careers by describing that cultural and structural barriers posed more of a barrier than the course content during their STEM education. Academic preparation often starts in early childhood education with exposure to STEM topics and continues through postsecondary education. The implications impact both the individual student and society. …

Determination Of The Effects Of Biogenic Metal Nanoparticles Concentrations On Soil Properties, Vicia Faba Growth And The Toxicity On Black Aphid, Ayoub Sabir Karim, Halala Rahman Qadr, Sakar Abdulqadr Saeed, Nashmeel Saeed Khudhur

Karbala International Journal of Modern Science

The development of nanomaterials could support more extensive agricultural uses, including nano-pesticides. Current study was conducted to observe the effects of different concentrations (25, 50, 75, 100, 150 and 200 ppm) of biosynthesized zinc oxide nanoparticles (ZnO NPs) and aluminum oxide nanoparticles (Al₂O₃ NPs) on soil, faba bean and toxicity on black aphid (Aphis fabae). The synthesized ZnO NPs from Musa paradisiaca L. characterized by ultraviolet (UV)-visible spectroscopy, Fourier Transform Infrared Spectroscopy, X-ray diffraction and Transmission electron microscopy. Al₂O₃ NPs was prepared by calcination of Iraqi kaolin via evaporation process. Highest pH …

Insights From Ethnobotanical Research In North America, Latin America, And West Africa Into The Phytochemical Quality, Pharmacokinetics, Pharmacodynamics, And Toxicology Of Botanicals, Robin Marles

Oxford ICSB

Insights perhaps worth sharing have been gained over a career spanning 50 years of ethnobotanical and pharmacognostic research on botanicals of Canada, Mexico, Ecuador, and Togo, and the development of standards on the quality, safety, and evidence-based uses of botanicals in health products and foods. Perspectives provided by traditional healers in these countries have informed approaches to a better understanding of, and possible goals for future research on traditionally used plants. This includes their phytochemical quality; absorption, distribution, metabolism, and excretion; possible mechanisms of action; and potential safety concerns. These insights will be illustrated by specific examples from research conducted …

Human Error, Human Factors And Production Ergonomics. A Discussion From The Perspective Of Biopharmaceutical Manufacturing, Ann Ryan

Level 3

No abstract provided.

Report On Optimal Methodologies For The Education Of Regulatory Assessors, Naomi Beard

Level 3

No abstract provided.

Preparation Of Nanoparticles And Study Of The Effect Of Some Of Their Physical Properties On Epoxy Polymer, Aya N. Abdullah, Niran F. Abeduljabbar

Al-Bahir

Nanoparticles were prepared by the laboratory thermal method from copper, magnesium, and zinc oxides. Different nanoparticles were added to epoxy at weight fractions of (0, 2, 4, 6, 8, 10) wt. %. The structural results from X-ray diffraction showed the appearance of epoxy in a random system, and when reinforced with nanopowders at higher addition ratios, we find the appearance of nanoparticles in a clear crystalline form, while the SEM results showed an increase in consistency and homogeneity with each increase in the proportions of nanoparticles, which appeared clearly during the EDX examination. The hardness of Shore type D was …

The Chanticleer, 2025-04-10, Coastal Carolina University

The Chanticleer Student Newspaper

The editorially independent student produced weekly newspaper of Coastal Carolina University.

Forever Tree, Alyse A. Petersen

Healy Poetry Prize

No abstract provided.

Brief Of Amici Curiae 676 Law Professors In Support Of Plaintiff’S Motion For Summary Judgment And For Declaratory And Permanent Injunctive Relief, Wilfred U. Codrington Iii, Rebecca Ingber, Rachel Landy, Jacob Noti-Victor, Alexander A. Reinert

Amicus Briefs

Amici 676 law professors submit this brief in support of Plaintiff Jenner & Block’s Motion for Summary Judgment and for Declaratory and Permanent Injunctive Relief (the “Motion”) to emphasize the threat that the President’s Executive Order (the “Order”) presents to the independence and integrity of the legal profession, the rights of clients to seek redress in the courts, and, by extension, the rule of law. As experts in constitutional law, legal ethics, and the history of the legal profession, among other fields, we have a significant interest in ensuring that the principles of free speech, freedom of association, the right …

The Disrupted Symphony Of Speech: A Lesion Network Mapping Analysis Of Apraxia Of Speech, Payton Harris, Harrison Moore, Milija Grotenhuis, Jared Nielsen, Michael A. Ferguson

FHSS Mentored Research Conference

Apraxia of Speech (AOS) is a motor speech disorder that causes difficulty planning and coordinating the movements necessary for speech. This study uses lesion network mapping to identify the neural connections of AOS by tracing lesion data and analyzing their functional connectivity patterns. Our data indicates strong connectivity between the left primary motor cortex and right premotor cortex. The findings of the left primary motor cortex differ from most AOS research but still correlate with regional functions found in healthy populations. However, results related to the right motor cortex were much less expected, and suggested a larger, understudied role in …

Modified Interferon-Gamma (Ifn-G) Receptors (Ifngr) To Enhance Cell-Based Immunotherapy, Eric Tran, Myungkyu Jang

Technology Transfer - Patents

No abstract provided.

The Current - Volume 35 Issue 12, Nova Southeastern University

Student Newspapers

No abstract provided.

Environmental Factors Exacerbate Parkinsonian Phenotypes In An Asian-Specific Knock-In Lrrk2 Risk Variant In Mice, Zoë Bichler, Sarivin Vanan, Zhiwei Zhang, Qianying (Sally) Dong, Jolene Wei Ling Lee, Chengwu Zhang, Liting Hang, Mei Jiang, Parasuraman Padmanabhan, Wuan Ting Saw, Zhidong Zhou, Balázs Gulyás, Kah Leong Lim, Li Zeng, Eng King Tan

Faculty Research 2025

Parkinson’s disease (PD) is a neurodegenerative disorder affecting nearly 10 mil- lion people worldwide, and for which no cure is currently known. Mutations in the Leucine-Rich Repeat Kinase 2 (LRRK2) gene, age, as well as environmental factors such as neurotoxin exposure and stress, are known to increase the risk of developing the disease in humans. To investigate the role of a specific Asian variant of the LRRK2 gene to induce susceptibility to stress and trigger PD phenotypes with time, knock-in (KI) mice bearing the human LRRK2 R1628P risk variant have been generated and studied from 2 to 16 months of …

Primary Care Brief Mindfulness Treatment Reduces Need For Clinical Services And Behavioral Healthcare, Dessa Bergen-Cico, Emily M. Johnson, Kyle Possemato, Mia Zappala, Allyson Smith, Robyn Sedotto

Voices of Service Symposium

Behavioral healthcare engagement is low for Post-Traumatic Stress Disorder (PTSD) even in systems where high-quality evidence-based psychotherapies (EBPs) are available. Mindfulness based interventions (MBI) may mitigate avoidance in treatment through self-regulation and non-judgmental self-awareness. This study analyzed treatment engagement and service utilization of Veterans engaged in a randomized clinical trial MBI for PTSD (A Primary Care Brief Mindfulness Training (PCBMT)) to assess its impact on behavioral healthcare engagement in populations with PTSD.

Seasonal Affective Disorder In College-Level Students, Kaylee Kirkeby

Psychology Student Publications

Seasonal Affective Disorder (SAD) is a mood disorder that causes depression in seasonal patterns, with winter being the most common. College students are particularly vulnerable to SAD due to factors like relocation, young age, and high social demand. The symptoms of seasonal effective disorder can be detrimental to a student’s career, and without specific knowledge of the causes and treatments for SAD, it is difficult to control the disorder.