Digital Commons Network^™

Tips For Quality Publishing; Lessons From The Neuroscience Editorial Team, Francesca Cirulli, Rachael Dangarembezi, Victor De Lafuente, Anthony J Hannan, Amanda C Kentner, Tatsuya Mima, Laurel Morris, Sarah J Spencer, Long-Jun Wu, Chen Zhang

The Brown Foundation: Institute of Molecular Medicine

In pursuit of excellence in scholarly publishing, the Neuroscience editorial team shares valuable insights that are essential for authors, reviewers, and the broader scientific community. Firstly, we emphasize that impactful research is built on rigorous study design and execution. Beyond fundamental methodological safeguards such as randomization and blinded analysis, we highlight the importance of thoughtfully selecting study models, with deliberate attention to biological variables like sex and gender, as well as appropriate nomenclature. Secondly, as technological innovations reshape research landscapes, we advocate for combining methodological rigor with suitable analytical tools to ensure robust data collection and transparent reporting. Thirdly, for …

Partnering With Social Media Influencers To Promote Hpv Vaccination In Diverse Communities, Amy Leader, Amelia Burke-Garcia, Dasha Afanaseva, Erin Cutroneo, Preethi Selvan, Kayla Madden, Joshua Banks, Angela Sustaita-Ruiz

Department of Medical Oncology Faculty Papers

BACKGROUND: While human papillomavirus (HPV) vaccination is one of the most effective ways to prevent HPV-related cancers, many children and adolescents remain unvaccinated. Resistance often stems from parental vaccine hesitancy and mistrust of the health care system, both of which may be higher in communities of color. Partnering with social media influencers may be an effective method for disseminating health messages. We tested the impact of HPV social media posts developed by influencers on outcomes of knowledge, attitudes, and intentions to vaccinate.

METHODS: Ten social media influencers who identified as African American or Hispanic created posts about the HPV vaccine. …

Mandibular Condylar Cartilage In Development And Diseases: A Pthrp-Centric View, Chiaki Tsutsumi-Arai, Amy Tran, Yuki Arai, Wanida Ono, Noriaki Ono

Faculty, Staff and Student Publications

The mandibular condylar cartilage (MCC) is a dual-function component of the temporomandibular joint (TMJ), acting as both articular cartilage for jaw movement and growth cartilage for vertical growth of the mandibular condyle. Parathyroid hormone-related protein (PTHrP) plays a critical role in orchestrating chondrogenesis in the long bone, and its importance is also highlighted in both MCC development and TMJ function. Here, we discuss the role of PTHrP in the development, growth and diseases of the MCC. PTHrP is a key morphogen in the MCC that regulates chondrogenesis by promoting chondrocyte proliferation and preventing premature hypertrophic differentiation. Exclusively expressed in the …

Structural Basis For Polθ-Helicase Dna Binding And Microhomology-Mediated End-Joining, Fumiaki Ito, Ziyuan Li, Leonid Minakhin, Htet A. Khant, Richard T. Pomerantz, Xiaojiang S. Chen

Department of Biochemistry and Molecular Biology Faculty Papers

DNA double-strand breaks (DSBs) present a critical threat to genomic integrity, often precipitating genomic instability and oncogenesis. Repair of DSBs predominantly occurs through homologous recombination (HR) and non-homologous end joining (NHEJ). In HR-deficient cells, DNA polymerase theta (Polθ) becomes critical for DSB repair via microhomology-mediated end joining (MMEJ), also termed theta-mediated end joining (TMEJ). Thus, Polθ is synthetically lethal with BRCA1/2 and other HR factors, underscoring its potential as a therapeutic target in HR-deficient cancers. However, the molecular mechanisms governing Polθ-mediated MMEJ remain poorly understood. Here we present a series of cryo-electron microscopy structures of the Polθ helicase domain (Polθ-hel) …

Trends In Celecoxib Prescribing: A Single Institution 16-Month Review, Ivo H Cerda, Helen Jung, Maria C Guerrero, Rodrigo Diez Tafur, Robert Jason Yong, Christopher L Robinson, Jamal J Hasoon

Faculty, Staff and Student Publications

Background/Objectives: Celecoxib, a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID), is widely prescribed for pain management due to its efficacy and improved gastrointestinal safety profile compared to traditional NSAIDs. Understanding prescription trends and their comparison to other NSAIDs provides valuable insight into prescribing behaviors in clinical settings.

Methods: This retrospective study analyzed celecoxib prescriptions written by three pain management physicians in a single institution over a 16-month period from 1 January 2023 to 30 April 2024. Prescription data were collected and grouped into four 4-month intervals to assess temporal trends. Additionally, we compared celecoxib prescriptions to other commonly prescribed NSAIDs, including …

Uncovering The Uncatalogued: Reviving The Museum’S Lost Catalog, Darrel Blevins

Public History Symposium

Darrelll Blevins presents his work in creating a new exhibit for the Clark County Heritage Center.

Scorpions Of The Horn Of Africa (Arachnida, Scorpiones). Part Xxxvii. The Genus Hemiscorpius (Hemiscorpiidae), František Kovařík, Hassan Sh A. Elmi, František Šťáhlavský

Euscorpius

Occurrence of the rare in the Horn of Africa genus Hemiscorpius Peters, 1861 (Scorpiones: Hemiscorpiidae) is summarized, including a distribution map. A male of Hemiscorpius lipsae Kovařík & Lowe, 2022 from Djibouti is described for the first time. A new species Hemiscorpius huluul sp. n. from Somaliland is described, fully complemented with color photographs.

Rethinking Money: How The Backfire Effect Shapes Consumer Reactions To Recommendations, Hee-Kyung Ahn, Eunkyoung Lee

Asia Marketing Journal

This research explored how priming of money influences consumers' reactions to others' opinions, particularly regarding compliance with different types of recommendations. Across two experiments, we found that subtle reminders of money made individuals value their independence in decision-making. As a result, they tended to respond negatively to recommendations that were overly prescriptive, such as specific product suggestions. On the other hand, when money reminders accompanied recommendations that offered some flexibility—like suggestions for product categories—individuals were more likely to agree with these flexible recommendations than specific suggestions. This effect even persisted when the category recommendations included only a single alternative.

Sga 56 Senate 2025-04-18 Minutes, Niu Student Government Association Senate

Student Government Association Archives

No abstract provided.

Longitudinal Assessment Of Blast-Related Traumatic Brain Injury (Tbi): Impact On Structural Neuroimaging Correlates, Working Memory, And Processing Speed, Carmen Velez

Dissertations

The conflicts in Afghanistan and Iraq led to a significant surge in blast-related traumatic brain injuries (bTBIs). However, our understanding of their lasting neurological impacts remains incomplete. To our knowledge, this is the first longitudinal study of its size to explore whether increasing levels of blast exposure predict neural atrophy or cognitive decline over time. We analyzed 149 baseline and follow-up data sets from service members categorized by blast exposure: blast naïve (n = 57), single blast (n = 70), and multiple blasts (n = 22). Participants underwent structural magnetic resonance imaging (MRI) and neuropsychological assessment.

All data were drawn …

Neural And Behavioral Changes In Consecutive Errors, Nabeel Bhimani

Research Honors

Consecutive failures in any task have been understudied in electrophysiology and neuroscience. Research identifies that single-errors tend to slow our response time to identify feedback and respond accordingly to ensure a correct response for the next task. However, evidence is limited regarding what the commission of consecutive errors does in relation to not only behavior, but also in relation to adaptations in attention or self-regulation. Electroencephalography (EEG) studies have revealed two important components of neural activity that can assess this self-regulatory activity with similar morphology and topography. The error positivity (Pe) is a positive wave that peaks due to the …

The Student Movement Volume 109 Issue 21: The Final Stretch: Expect The Unexpected, Audrey Lim, Marco Sciarabba, Andrew Francis, Ember Clark, Nate Miller, Melanie Webb, Addison Randall, Melissa Moore, Natalie Reid, Aiko J. Ayala Rios, Nora Martin, Amelia Stefanescu

The Student Movement V. 109 (2024-2025)

HUMANS

AAPI Heritage: An Interview With KASA President Abby Shim, Audrey Lim

Technology to the Rescue: AI Use in the Classroom, Marco Sciarabba

Andrews Biology Professor Tom Goodwin Retiring After 30 Years, Andrew Francis

International College Students at Risk During String of Visa Cancellations, Detainments, Andrew Francis

ARTS & ENTERTAINMENT

Crafted With Purpose: The Story Behind Made at Andrews, Ember Clark

Music Department Hosts Unique Opera Performance, Nate Miller

Carla Trynchuk and Elena Braslavsky to Perform at HPAC, Melanie Webb

Symphony Orchestra Says "Thank You" To WAUS, Addison Randall

NEWS

Unexpected: Gymnics 2025 Home Show, Melissa Moore

IDEAS

What Fan …

Imine Crosslinked, Injectable, And Self-Healing Fucoidan Hydrogel With Immunomodulatory Properties, Asma Talib Qureshi, Shajia Afrin, Saad Asim, Muhammad Rizwan

Michigan Tech Publications

Biomaterials with inherent anti-inflammatory properties and the ability to foster a pro-regenerative environment hold significant promise for enhancing cell transplantation and tissue regeneration. Fucoidan, a sulfated polysaccharide with well-documented immune-regulatory and antioxidant capabilities, offers strong potential for creating such biomaterials. Yet, there is a lack of engineered fucoidan hydrogels that are injectable and provide tunable physicochemical properties. In this study, the ability of fucoidan to undergo periodate-mediated oxidation is leveraged to introduce aldehydes into backbone (oxidized fucoidan, OFu), enabling the formation of reversible, imine-crosslinks with amine-containing molecules such as gelatin. The imine-crosslinked OFu-gelatin hydrogel provided excellent control over gelation rate …

Effects Of Citric Acid, Synbiotic, And Probiotic Supplementation Through Drinking Water On Growth Performance, Carcass Yield, And Blood Biochemistry Of Broiler Chickens, Shahadot Hossain, Biswajit Kumar Biswas, Subir Das, Faija Sadia Pory, Rabin Raut, Fatima Yeasmin, Sharif Uddin Khan, Prantho Malakar Dipta, Sabbir Alom Shuvo, Tahera Yeasmin, Raihanul Hoque

Food and Animal Sciences Faculty Research

No abstract provided.

I Am Guillotine, Nathanael Joseph Williams

Fiction MFA Theses

63 years after the Mad War, an exchange of nuclear, chemical, and biological weapons, a twelve-year old girl wakes up on a train. She has no memory of where she comes from or who she was before the train, but when it stops, there is no doubt that she is now a slave. Brought to the town of Bludgeonburg in chains, she is sold off, along with a boy named Mohawk, to a man named Aabrax as a pit slave. The odd are firmly against Aabrax, and Gilly is not expected to survive, but by a stroke of luck, she …

"Peace [That] Could Only Be Amazement, Too": Narrativizing Wonder And Strangeness In Marilynne Robinson's Lila, Tricia Cope

Theses and Dissertations

Set against the backdrop of the mid-twentieth century American Midwest, Marilynne Robinson's Lila is a profound story of loss and redemption told through the perspective of a young woman who emerges from a childhood of trauma and neglect and begins a new life in the quiet town of Gilead, Iowa. This paper examines the novel as a narrative meditation on the theological and ontological dimensions of wonder. While its fragmented structure and bleak subject matter have led some critics to interpret the novel as emotionally fractured or pessimistic, I argue that its recursive form and narrative disorientation are deliberate formal …

Pilot Study For Examining The Physiological Effects Of Sustained Attention In A Structured Online Mindfulness-Based Course, Eve Barton

Theses and Dissertations

Mindfulness-based interventions (MBI's) and courses have emerged as widely recognized approaches for promoting mental health, improving cognitive functioning, and fostering overall well-being. This pilot study explored the effects of a 15-session, online, structured mindfulness course on sustained attention and subjective well-being, utilizing both objective and subjective measures. The study aimed to determine whether participants' sustained attention, assessed via a smooth pursuit eye movement (SPEM) task, improved after completing the online course. Subjective attention was measured using the Attentional Control Scale (ACS) and a single item from the Adult ADHD Self-Report Scale (ASRS), while subjective well-being was assessed using the Survey …

Enabling Next-Generation Microfluidics Through Advances In High-Resolution 3d Printing, Matthew S. Viglione

Theses and Dissertations

This dissertation advances the field of microfluidic device fabrication through the development and application of high-resolution 3D printing technologies. The convergence of stereolithography (SLA) with digital light processing (DLP) has created unprecedented opportunities for microfluidic device fabrication, enabling truly three-dimensional structures with feature sizes approaching the single-micron scale. Building upon foundational work in custom 3D printer development, this research addresses critical limitations in 3D printing that have historically constrained microfluidic innovation, spanning multiple generations of custom 3D printers and technical innovations that have enabled the fabrication of increasingly complex microfluidic devices while enhancing resolution, repeatability, speed, and accessibility. A comprehensive …

Deliberate Practice For Multicultural Orientation Training Novice Undergraduates, Eduardo E. Duran

Theses and Dissertations

This study explores the efficacy of Multicultural Orientation (MCO) and Motivational Interviewing (MI) frameworks in enhancing undergraduates' ability to address cultural dynamics in therapeutic contexts through deliberate practice. Using a randomized control trial design, 59 participants were assigned to either an MCO as the experimental group or an MI workshop as the control group, each involving pre- and post-workshop video simulations and self-reported assessments. The workshops incorporated deliberate practice exercises with feedback to improve participants' responses to culturally rich client scenarios. Findings indicated significant improvements in cultural humility, comfort, and opportunities for the MCO group compared to the MI group. …

Amyotrophic Lateral Sclerosis And Frontotemporal Dementia Mutation Reduces Endothelial Tdp-43 And Causes Blood-Brain Barrier Defects., Ashok Cheemala, Amy L Kimble, Emily N Burrage, Stephen B Helming, Jordan D Tyburski, Nathan K Leclair, Omar M Omar, Aamir Zuberi, Melissa Murphy, Evan R Jellison, Bo Reese, Xiangyou Hu, Cathleen Lutz, Riqiang Yan, Patrick A Murphy

Faculty Research 2025

Mutations in the TARDBP gene encoding TDP-43 protein are linked to loss of function in neurons and familial frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). We recently identified reduced nuclear TDP-43 in capillary endothelial cells (ECs) of donors with ALS-FTD. Because blood-brain barrier (BBB) permeability increases in ALS-FTD, we postulated that reduced nuclear TDP-43 in ECs might contribute. Here, we show that nuclear TDP-43 is reduced in ECs of mice with an ALS-FTD–associated mutation in TDP-43 (Tardbp^G348C) and that this leads to cell-autonomous loss of junctional complexes and BBB integrity. Targeted excision of TDP-43 in brain …

Enhancing The Development Of Critical Thinking Skills Through The Implementation Of Trauma-Informed Project-Based Learning, Megan E. Coleman

Masters Projects

Many students struggle to develop critical thinking skills, which are considered essential skills in life. While research supports the need for the development of these skills in young adults, many educators struggle to be successful in helping students develop these skills. Project-based learning (PBL) has been shown to be a successful tool in navigating the development of these skills, but research over the years has shown that teachers face many barriers in its implementation. In addition to the challenges of curriculum, students also face barriers in their development of these skills due to the exposure of trauma. Because of the …

Motivating Remote Working Employees, Sandesh Bilgi

Doctoral Dissertations and Projects

The purpose of this qualitative phenomenological study was to explore how remote employees who have previously worked in-person describe their lived and perceived experience with motivation in remote working environments. Participants completed the Work Extrinsic and Intrinsic Motivation Scale (WEIMS), which measures degrees of work-related motivation among employees focusing on traits that signify each worker’s intrinsically or extrinsically motivated nature. Through in-depth interviews with 30 participants, this research examined how remote workers are motivated in remote work settings, which factors increase or decrease motivation, and how leaders can influence the motivation levels of their employees. The interviews were conducted online, …

The Consequences Of Social Isolation On Early Adolescent Youth: The Rise Of Gender Identity Questioning, Rachele Hauck

Doctoral Dissertations and Projects

The year 2020 brought forth a global pandemic that changed the way human beings went about their daily life. Coinciding at the same point in history, the number of adolescents questioning their gender identity almost doubled. This transcendental phenomenological qualitative study sought to understand the journeys of seven adolescents surviving the stay-at-home mandates put in place by officials attempting to decrease the spread of COVID-19 in a rural midwestern town. These participants identify as a gender that does not align with the gender they were given at birth. Their voices are documented with subject led interviews and attention to expressionistic …

Examining The Effects Of Work-Related Musculoskeletal Disorder Pain On Healthcare And Allied Health Professionals' Quality Of Life, Nicole Simone Richmond

Doctoral Dissertations and Projects

The purpose of this phenomenological study is to understand the effects work-related musculoskeletal disorder pain has on the quality of life of high body mass indexed healthcare and allied health professional women. This qualitative research incorporated virtual semi-structured interviews, via zoom, of 10 clinically obese female healthcare and allied health workers employed at a hospital, clinic, or private health practice; and have been diagnosed by a medical doctor with a case of chronic work-related musculoskeletal disorder pain within the past six months. The study utilized a virtual setting of participants who reside and work within the United States. Data collection …

Teacher Stress, Resilience, And Experience: A Correlational Study, Kelsey D. Valente

Doctoral Dissertations and Projects

The teaching profession is one of the most critical, yet challenging occupations. The purpose of this dissertation was to identify and articulate the importance of the study exploring the teaching occupation and stress. Specifically, the purpose of the quantitative study was to explore the relationship between self-report educator stress, self-report of resilience, and years of teaching experience. The minimum sample size, determined by a priori power analysis, was 67; however, there were 68 participants in the study. Participants included current, public school educators ages 18 and older licensed to teach in South Carolina. Data collection was completed through three self-report …

Multiple Platform Social Media Engagement Correlation With Perceived Depression, Anxiety, And Stress Among Active Church Members, Penny K. Hampton

Doctoral Dissertations and Projects

Social media has remained an area that each person has related to in their everyday experiences. The growth of social media has continued and expanded to include a wide range of varying platform opportunities for users. Given the variances with social media engagements, everyone differs with their resulting overall mental health characteristics. This study explored the relationship between the user engagement on multiple social media platforms and self-reported depression, stress, and anxiety. The variables included the number of social media platforms and the self-reported responses to the Depression, Anxiety, Stress Scale-21 (DASS21). For this study, the participants included 117 individuals …

A Phenomenology Of The Importance Of Protection As It Relates To The Father And Daughter Relationship, Jared B. Reid

Doctoral Dissertations and Projects

The purpose of this phenomenological study is to better understand the lived experience of a father’s relationship with his daughter(s) and how the central theme of protection impacts that relationship. Protection will be generally defined as a father’s ability to provide boundaries physically, spiritually, and emotionally around his family, created by safety and trust, in developing stability for healthy development. General research questions include but are not limited to, what necessitates a family to need protection. What is the impact on a daughter when the father does not protect her? The purpose of this phenomenological study is to investigate the …

Synthesis, Characterization And Biological Activity Of New Ligand Derived From 4-(Dimethylamino) Benzaldehyde And Nano Copper Complex, Enass J. Waheed

Baghdad Science Journal

The general formula of new complexes [M₂(BDS)Cl₄] are resulting from the reaction of a new ligand [N1, N4- bis (1H- benzo [d] imidazol- 2- yl) -N1, N4 -bis(4-(dimethyl amino) benzyl) succinimide] (BDS) with metal ions M(II) = Cd, Co, Hg, Cu and Ni. This ligand was derived from the reaction of the three substances 4-(Dimethyl amino) benzaldehyde, 2-amino benzimidazole, and succinyl chloride. The compounds are characterized by FT-IR, NMR, UV-Vis and Mass spectroscopy. The serine protease SplB of Staphylococcus aureus and the A chain of Rhomboid-protease-GLPG of Escherichia coli were chosen to study the binding strength …

Adjuvant Radiotherapy In Pt3-4n0m0 Major Salivary Gland Cancer Without Other Adverse Features, Aman M. Patel, Afash Haleem, Praneet C. Kaki, Jake J. Lee, Russell Maxwell, Jason A. Brant, Robert M. Brody, Ryan M. Carey

SKMC Student Presentations and Publications

OBJECTIVE: To investigate adjuvant radiotherapy (aRT) utilization and associated differences in overall survival (OS) in pT3-4N0M0 major salivary gland cancer (MSGC) without evidence of other adverse pathologic features.

METHODS: The 2006 to 2018 National Cancer Database was queried for patients with MSGC classified as pT3-4N0M0. Patients with evidence of lymphovascular invasion or positive surgical margins were excluded. Multivariable binary logistic and Cox regression models adjusting for patient demographics, pathologic features including histology, and treatment were implemented.

RESULTS: Of 897 patients satisfying inclusion criteria, 368 (41.0 %) underwent aRT. Compared with those not undergoing aRT, patients undergoing aRT were younger (median …

Kenyon Collegiate - April 18, 2025

Kenyon Collegiate

No abstract provided.