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Analysis Of Differentially Expressed Genes (Degs) Related To Interleukin-17 Signaling For Biomarker Identification And Therapeutic Targets In Atopic Eczema, Siva Fauziah, Weri Veranita, Siti Nurbaya, Puji Sari

Indonesian Journal of Medical Chemistry and Bioinformatics

Atopic eczema, also known as atopic dermatitis, is a chronic inflammatory skin condition characterized by itchy, red, and swollen skin. It is often associated with other atopic diseases such as asthma and hay fever. Interleukin-17 (IL-17), a pro-inflammatory cytokine, plays a crucial role in various inflammatory and autoimmune conditions, including atopic eczema. This study aims to identify potential therapeutic targets for managing atopic eczema based on the analysis of differentially expressed genes (DEGs). The expression of these gene targets was subsequently validated for their potential as biomarkers. Additionally, upstream regulator protein (URP) searches for the resulting DEGs were conducted. DEG …

Spectator 2025-04-24, Editors Of The Spectator

The Spectator

No abstract provided.

Agriculture And Natural Resources Committee Clemson University Board Of Trustees 2025 April 24, Clemson University Board Of Trustees

Minutes

No abstract provided.

Meta-Transcriptomes Of The Microbial Communities Of The Different Developmental Life Stages Of Anastrepha Ludens (Diptera: Tephritidae), Erin L. Schuenzel

School of Integrative Biological & Chemical Sciences Faculty Publications

The Mexican fruit fly, Anastrepha ludens, is a polyphagous pest that is a constant threat to US agriculture because of its proximity to citrus production in border region of the United States and Mexico. Sterile Insect Technique has been used to manage and eradicate of the Mexican Fruit Fly. SIT, however, requires millions of sterile male flies to be released each week from mass-rearing facilities. The mass-reared colonies must deal with microbial infections that reduce survivorship, fecundity and male-male competition. Meta-transcriptomics joins culturing and next generation DNA sequencing techniques to understand these changing microbial communities. This study uses advances …

“We Live In A Spiritual Country”: The Associations Among Health Literacy, Quality Of Life, And Religious Spiritual Personal Beliefs Among The Nigerian Population, Rebecca Aderoju

Electronic Theses and Dissertations Archive

This dissertation examines the complex interplay between health literacy (HL), quality of life (QoL), and spiritual and religious beliefs (SRPB) among underserved populations in Nigeria. Despite increasing awareness of healthcare options, many Nigerians continue to rely on faith-based healing practices due to deeply rooted religious and cultural traditions, economic barriers, and systemic healthcare limitations. Using a mixed-methods approach, this research incorporates both survey data and focus group discussions to investigate the relationship that Nigerians make among these variables. This study employs the Social Ecological Model (SEM) to explore how individual, interpersonal, community, organizational, and policy factors shape health behaviors and …

Discovering New Plant-Based Compounds To Treat Oral Diseases: An Independent Research Project, Daileen Serrano, Jenna Yehyawi, Danielle Orozco-Nunnelly, Jeffrey Pruet

Symposium on Research and Creative Expression (SORCE)

Infectious diseases are cited as one of the main causes of death worldwide. Many drugs to treat such illnesses were discovered in the mid-1900s, but this type of research has declined in recent years. At the same time, antimicrobial-resistant “superbug” infections are on the rise, including superbug biofilms present in the oral cavity, which are responsible for diseases such as tooth decay, gum disease, and implant failure. Therefore, I have been working to explore various plants from a medicinal garden on the Valparaiso University campus to screen extracts against common disease-causing oral bacteria with the goal of discovering novel compounds …

Assessing Indoor Air Quality In Industrialized Residential Areas Using Solid-Phase Microextraction And Silicon Wristbands For Voc Detection, Emily Broniewicz, Julie Peller

Symposium on Research and Creative Expression (SORCE)

Indoor air quality is often overlooked, yet it plays a critical role in human health, particularly for communities located in industrial zones where air pollution is prevalent. Exposure to volatile and semi-volatile organic compounds (VOCs) can contribute to a range of health problems, including respiratory issues, neurological effects, and long-term chronic diseases. Understanding both indoor air quality and personal exposure to these pollutants is essential for evaluating public health risks, especially in residential areas near pollution-emitting industries. This study aims to assess VOC levels in both indoor environments and personal exposure in Northwest Indiana, particularly near industrial zones, with comparisons …

Exploring Plant-Derived Compounds To Combat Microbial Infections Related To Space Travel, Karson Hollander, Gracie Holt, Megan Wolf, Sabrina Ezell, Jeffrey Pruet, Danielle Orozco-Nunnelly

Symposium on Research and Creative Expression (SORCE)

Novel antimicrobial agents are crucial due to rising superbugs and declining drug development, threatening millions by 2050. In addition to being a terrestrial cause for concern, antimicrobial resistant microbes threaten the health of individuals during space travel. Recent studies show several opportunistic bacteria and fungi have colonized the International Space Station (ISS), and many strains possess antimicrobial resistance. Additionally, reports have highlighted how space travel may alter the immune system, placing astronauts at higher risk of infection. Therefore, our research focuses on testing bacterial and fungal pathogens that have been isolated on the ISS against methanolic and hexane extracts of …

The Effect Of Midwest Precipitation Extremes On Growth Phenotypes In Arabidopsis Thaliana: A Quantitative Genetics Perspective, Ashlee Swierc, Abby Boyle, Jane Kenney-Hunt

Symposium on Research and Creative Expression (SORCE)

Seasonal precipitation patterns in the Great Lakes region of the Midwest are becoming increasingly unpredictable, with spring floods and extreme summer heat creating challenges to terrestrial plant life. Disruptions in climatic conditions can impact environmental conservation efforts and agriculture within the region. As a major exporter of corn and soybeans, the unprecedented effects faced in the Midwest will have a large influence on agricultural production and food availability. We simulated the effects of these extremes in precipitation on 100 Arabidopsis thaliana recombinant inbred lines (RIL) to investigate gene-by-environment interactions on five growth and development phenotypes (days to germinate, bolt, leaf, …

Probing Medicinal Plants For Novel Antimicrobial Compounds, Edgar Padilla, Sabrina Ezell, Leah Streetman, Nolan Brezina

Symposium on Research and Creative Expression (SORCE)

According to the W.H.O., infectious diseases account for three of the top ten global causes of death. Antimicrobial drug discovery surged in the mid-twentieth century but has sharply declined in recent years. At the same time, antimicrobial-resistant “superbug” infections are on the rise. Plants produce a robust array of novel metabolic compounds including many antimicrobial agents. However, with the advent of modern antibiotic drugs, natural plant-derived antibiotic sources have largely been left unexplored. Therefore, our work focuses on screening under explored medicinal plants in hopes of discovering novel antimicrobial drugs. To accomplish this, we have been testing extracts of plants …

Production And Maintenance Of Proper Neuron Numbers In The Developing And Aging Retina By Nell2, Adelyn R. Carney, Cory Meyers, Timmy Benz, Chizu M. Nakamoto, Masaru Nakamoto

Symposium on Research and Creative Expression (SORCE)

Nervous system functionality depends on the generation and maintenance of the proper numbers of neurons. However, the molecular mechanisms that control the number of neurons produced during development and support long term neuronal survival are not fully understood. Nell2 is a multi-modular extracellular glycoprotein predominantly expressed in the nervous system. Nell2 exerts diverse functions in neural development, including regulation of neuronal proliferation and differentiation, and neuronal network formation. Our previous study has shown that Nell2 acts as an inhibitory guidance cue for retinal axons in the eye-specific visual (retinogeniculate) projection. In this study, we investigated the function of Nell2 in …

Effect Of Simulated Microgravity On Candida Albicans Resistance To Antifungal Drugs, Matthew Gaetano, Kendall Carter, George Gundelach, Patrice Bouyer, Grace Jendreas

Symposium on Research and Creative Expression (SORCE)

Candida albicans is an opportunistic commensal fungus that can respond to the stress of low-shear modeled microgravity by exhibiting phenotypes associated with increased virulence. In previous studies, C. albicans have demonstrated increased resistance to amphotericin B under microgravity conditions, but no change in resistance to caspofungin. Here, we investigated how microgravity (3 and 5 days) influences the resistance of two C. albicans strains (SC5314 and from Carolina) to clotrimazole (200 µg/µl) and amphotericin B (250 µg/µl). Resistance was evaluated by measuring the zone of inhibition (ZOI) around the treatment discs after 24 hours of exposure to the drugs in the …

Neither Here Nor There: Passing Through Race, Culture, Transnationalism, And Generational Inheritance In Mixed-Race Japanese American Literature, Rachel Kelly

English Honors Projects

My honors project explores the concept of passing in Japanese American mixed-race literature written after World War II by examining how acts of passing are racially, transnationally, and formally represented in Ruth Ozeki’s novel, My Year of Meats; Asako Serizawa’s novel-in-stories, Inheritors; and Brian Komei Dempster’s poetry collection, Topaz. Through my analysis, I seek to expand traditional notions of racial passing by reconceptualizing the term's connection to physical and spatial mobility, generational inheritances, and literary forms in order to recognize and celebrate mixed-race Japanese American voices within larger conversations by and around Asian American and BIPOC American …

Leveraging Lower Body Negative Pressure For Enhanced Outcomes In Orthopedic Arthroplasty—Insights From Nasa’S Bone Health Research, Phani Paladugu, Rahul Kumar, Tamer Hage, Swapna Vaja, Tejas Sekhar, Samuel Weisberg, Kyle Sporn, Ethan Waisberg, Joshua Ong, Amar S. Vadhera, Mouayad Masalkhi, Ryung Lee, Chirag Gowda, Ram Jagadeesan, Nasif Zaman, Alireza Tavakkoli

SKMC Student Presentations and Publications

Exposure to microgravity causes rapid bone loss and muscle atrophy, posing serious challenges for long-duration spaceflight. In response, NASA developed countermeasures such as Lower Body Negative Pressure (LBNP) to simulate gravitational loading on astronauts’ lower extremities. LBNP, often combined with exercise, has proven effective in mitigating musculoskeletal degradation during bed rest analogs. This opinion paper argues that LBNP’s success in preserving bone mass and muscle function in microgravity can be translated to improve re- covery after orthopedic arthroplasty on Earth. We draw physiological parallels between microgravity-induced musculoskeletal disuse and the postoperative period following total joint replacement, during which reduced weight-bearing …

Hepatic Manifestations Following Gene Therapy, Akash Roy, Shalini Bansal, Anand Kulkarni, K. Rajender Reddy

SKMC Student Presentations and Publications

Gene therapy involves the introduction of genetic materials, most commonly using viral vectors, to alter gene expression to ameliorate or cure disease symptoms with minimal adverse events. While interest in gene therapy has been on the increase, concerns have arisen about the potential for hepatotoxicity, which arises from diverse mechanisms. While viral vectors can produce dose-dependent hepatotoxicity secondary to integration, immune responses appear to be the primary driving mechanism. A mild increase in aminotransferases is the most common hepatic manifestation, occurring variably in 20%-80%, while there has been rare progress to acute liver failure. The occurrence of hepatotoxicity is unpredictable …

The Controversy And Ethics Behind Zoos, Merin R. Boucher

Intertext

No abstract provided.

How To Go To Hell: The Ethics Of Religious Interpretation, Ilhy Gomez Del Campo Rojas

Intertext

No abstract provided.

Complete Issue - Intertext 2025, Intertext Journal

Intertext

No abstract provided.

Work-Life Balance Conflicts Parents Of Early Adolescents Faced During Covid-19 Lockdowns, Rodney Smith

Walden Dissertations and Doctoral Studies

Measures such as social distancing and lockdowns during the COVID-19 pandemic meant parents balanced their roles as educators, tech support, and employees in shared home offices. This qualitative phenomenological study was to investigate the work-life balance conflicts parents of early adolescents faced during the COVID-19 lockdowns, focusing on how parents managed the challenges of pandemic restrictions and their strategies for coping with cognitive, emotional, and physical fatigue for themselves and their families. This study was guided by the transactional theory of stress and coping. Twelve female parents were virtually interviewed, selected based on their having early adolescent children at home, …

Primary Central Nervous System Lymphoma: Predictors Of Response To Induction Therapy And Patterns Of Progression, Louis Cappelli, Allison Kayne, Jennifer Newman, Ahmed Elguindy, Narendranath Epperla, Joshua D. Palmer, Ubaldo E. Martinez-Outshoorn, Pierluigi Porcu, Wenyin Shi, Iyad Alnahhas

Department of Radiation Oncology Faculty Papers

BACKGROUND: Primary central nervous system lymphoma (PCNSL) is a rare and aggressive variant of non-Hodgkin lymphoma. While PCNSL is often sensitive to induction high-dose methotrexate (HDMTX) based chemotherapy, recurrence rates remain high, approaching 50% within 5 years. The most common molecular alterations in PCNSL include mutations in MYD88 and CD79 and CDKN2A homozygous deletion. There are no predictive or prognostic molecular markers in PCNSL.

METHODS: We conducted a retrospective review of 40 patients with PCNSL treated at Thomas Jefferson University and Ohio State University between 2011 and 2023. We created a clinically annotated database of patient characteristics and outcomes. For …

Relationship Between Within-Session Digital Motor Skill Acquisition And Alzheimer Disease Risk Factors Among The Mindcrowd Cohort: Cross-Sectional Descriptive Study, Andrew Hooyman, Matt J. Huentelman, Matt De Both, Lee Ryan, Kevin Duff, Sydney Y. Schaefer

Physical Therapy Faculty Articles and Research

Background: Previous research has shown that in-lab motor skill acquisition (supervised by an experimenter) is sensitive to biomarkers of Alzheimer disease (AD). However, remote unsupervised screening of AD risk through a skill-based task via the web has the potential to sample a wider and more diverse pool of individuals at scale.

Objective: The purpose of this study was to examine a web-based motor skill game (“Super G”) and its sensitivity to risk factors of AD (eg, age, sex, APOE ε4 carrier status, and verbal learning deficits).

Methods:Emails were sent to 662 previous MindCrowd participants who had agreed …

Advanced Manufacturing Of Multifunctional Shape Memory Polymer Composites And Self-Healing Systems, John B. Konlan

LSU Doctoral Dissertations

The need for multifunctional light weight structures for engineering applications is on the rise. Multifunctional composites are desired because of their ability to combine multiple functionalities into one structure. The advantages of a high strength-to-weight ratio of multifunctional composites make them desirable and suitable for use in energy-efficient applications. Shape-memory polymers (SMPs) have attracted interest over the past several decades because of their multifunctional nature. They have found use in many applications such as aerospace, satellites, automobiles, textiles, and biomedical devices, where lightweight and multifunctionality are key. The self-healing nature of most SMPs makes them suitable for use in lightweight …

Fishing For Solutions: Compensation For Bycatch Reduction In The Gulf Of Mexico Shrimp Fishery, Daniel W. Harris

LSU Master's Theses

Bycatch, unintentionally caught non-target species, harms the profitability of commercial fishing operations and leads to death and injury of hundreds of thousands of marine animals per year. In the Gulf of Mexico, commercial shrimpers are required to use a bycatch reduction device (BRD). Better BRDs are being tested to further reduce bycatch. Because their use will not be mandatory, it is important to measure shrimper willingness to voluntarily adopt this conservation technology to predict potential fleet participation. This study uses contingent valuation to elicit commercial shrimpers’ willingness to accept compensation for using these new devices.

We employ an incentivized payment …

Proteomic Comparison Of Canine Gallbladder Versus Hepatic Neuroendocrine Neoplasms, Nadia Richmond

LSU Master's Theses

Hepatobiliary neuroendocrine neoplasms (HBNENs) are uncommon tumors in people and dogs, and the limited understanding of their biologic behavior often poses a diagnostic and prognostic challenge in the clinical setting. Though only a low number of cases have been described in dogs, there is evidence to indicate that primary gallbladder NENs may carry a more favorable prognosis compared to primary hepatic NENs. The emergence of liquid chromatography-mass spectrometry (LC-MS) in proteomic analysis has permitted large-scale analysis of neoplastic proteomes, allowing for better understanding of tumor pathophysiology while simultaneously enabling the rapid identification of protein biomarkers. Previous work in our laboratory …

Editorial: Women In Science: Allergy Research, Gemma Carreras-Badosa, Vanesa Esteban, Vivian Hernandez-Trujillo, Elina Toskala, Manali Mukherjee, Saba Al Heialy, Karin Fieten

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

No abstract provided.

Jtc 25: Rescuing Our Natural World, Staff Report

University of Mississippi News

This story is part of the 2025 Journey to Commencement series, which celebrates the pinnacle of the academic year by highlighting University of Mississippi students and their outstanding academic and personal journeys from college student to college graduate.

The Application Of Gibberellin On Dwarf Mutant Millet Plant (Setaria Viridis), Catherine Philipps, Desirae Snyder, Elizabeth Dill, Joselyn Wood, Kaneez Moughal, Katherine Kellner, Rachel Wilson

2025 Student Academic Showcase

Gibberellin is a hormone found in many plants whose purpose is to promote the growth of stems and leaves. The application of gibberellin in differing concentrations was applied to different strains of dwarf mutant millet plants and was compared to a control of nonmutant wild-type millet plants. After the initial sprouting of each seed, 4 different concentrations of gibberellin: 0g gibberellin/1L water, 0.02g/L, 0.05g/L, and 0.15g/L, were applied to the stem of each plant. A regression analysis was performed on the heights of each plant to determine the effectiveness of the varying gibberellin concentrations on the growth of millet plants. …

Early Birds Or Night Owls: Who Is Getting The Best Sleep?, Josie Davis

2025 Student Academic Showcase

Chronotyping is categorizing individuals based on their sleep schedules. The two chronotypes are morning-types (M-type) and eveningtypes (E-types; Montralu et al., 2021). Heinrich et al. (2021) found that M-type individuals experienced better sleep quality than E-type individuals. Approximately 200 full time working individuals aged 20+ will be surveyed on their chronotype, sleep quality, and preferred exercise time. We hypothesize that M-type individuals will report better sleep quality than E-type individuals and will use an independent samples t-test to assess this. Additionally, we will categorize participants on matching or non-matching of chronotype and preferred exercise timing. The expectation is that the …

Dietary Preferences And Food-Seeking Behavior Of Discoid Cockroaches, Blaberus Discoidalis, Claire O'Brien, Darcci Freie, Robert Larson

2025 Student Academic Showcase

Blaberus discoidalis, commonly known as discoid cockroaches, are native to South American tropics where they consume leaf litter and decaying organic matter on forest floors. This experiment expands upon previous research concerning the diet preference of discoid cockroaches based on their loitering time when presented with different food types. Utilizing their preferred foods, peanuts, leaf litter, and banana, this experiment aims to determine how much of each food is being consumed to further support their diet preferences.

Gibberlin In Millet Physiology, Torrie Ens, Bella Reaka, Claire Albrecht, Hannah Smallwood, Will Graham, Adam Staley, Garrett Steger, Erin Strong

2025 Student Academic Showcase

Gibberellin is a hormone in plants that affects growth. Gibberellin works to begin germination in grass seeds by stimulating amylase production. It may be possible to use gibberellin to understand why different millet variants exhibit dwarf growth. We grew and treated 4 different dwarf variants with a gibberellic acid solution to identify the ability of each plant to utilize gibberellin. We compared the growth in millet grown both with and without the solution to see the effects of gibberellin on each variant. Dwarf millets may not produce their own gibberellin, or they may lack the receptors to utilize gibberellin. Our …