Digital Commons Network^™

Participant 012: Reiki Master With Three Months Of Experience (Asian American & White; Female; New York, Usa)

0885: Reiki and Well-Being Interviews

This is an interview about Reiki and its connection with overall well-being with a Reiki Master holding three months of experience (Asian American & White; Female; New York, USA). She was interviewed on May 21, 2025. The participant agreed to the terms outlined in the verbal informed consent form before this interview. Some of the broad conversations during this interview include the full circle moments of finding aspects of spirituality as a young adult, but revising it when you're older; her first experience with a Reiki session being during her Reiki I attunement; Reiki's place in helping participant find self-love …

Unmasking Midfoot Pain: A Rare Case Report Of The Bipartite Medial Cuneiform Management, Andrew Silman, Syed Ahmed

Advocate GME

No abstract provided.

A Review Of Mirvetuximab Soravtansine-Gynx In Folate Receptor Alpha-Expressing Platinum-Resistant Ovarian Cancer

Faculty, Staff and Student Publications

Purpose: To evaluate the pharmacology, efficacy, safety, and dosing and administration considerations (including adjusted ideal body weight [AIBW] dosing) for mirvetuximab soravtansine-gynx, a first-in-class folate receptor alpha (FRα)-directed antibody-drug conjugate for platinum-resistant ovarian cancer (PROC).

Summary: A literature search was conducted in PubMed using the terms "ovarian cancer" and "mirvetuximab soravtansine" of articles published from inception to April 16, 2024. Relevant publications, abstracts, and clinical trials were reviewed. Mirvetuximab soravtansine-gynx is dosed at 6 mg/kg AIBW every 3 weeks and comprises an FRα-binding antibody, a hydrophilic disulfide linker, and a maytansinoid DM4 payload. Mirvetuximab soravtansine-gynx binds to FRα, which induces …

Global Dna Methylation Differences Involving Germline Structural Variation Impact Gene Expression In Pediatric Brain Tumors, Fengju Chen, Yiqun Zhang, Wei Li, Fritz J Sedlazeck, Lanlan Shen, Chad J Creighton

Children’s Nutrition Research Center Staff Publications

The extent of genetic variation and its influence on gene expression across multiple tissue and cellular contexts is still being characterized, with germline Structural Variants (SVs) being historically understudied. DNA methylation also represents a component of normal germline variation across individuals. Here, we combine germline SVs (by short-read sequencing) with tumor DNA methylation across 1292 pediatric brain tumor patients. For thousands of methylation probes for CpG Islands (CGIs) or enhancers, rare and common SV breakpoints upstream or downstream associate with differential methylation in tumors spanning various histologic types, a significant subset involving genes with SV-associated differential expression. Cancer predisposition genes …

Taxation Of Computer Technology, Robert L. Black, Craig E. Reese

Tax Adviser

No abstract provided.

006. Bohumil Shimek (1904-05) [Biography]

Presidents of the Iowa Academy of Science

No abstract provided.

Ph Dependent Structural Characterization Of Ich Ensembles Needed For Catalysis, Kevin C. Prososki

Honors Program: Senior Projects (Public)

No abstract provided.

Investigating The Role Of Lysophosphatidic Acid Receptor 3 In Ocular Surface Ion Transport And Fluid Secretion, Ethan Lindgren

Natural Sciences and Mathematics | Biological Sciences Master's Theses

Dry eye disease (DED) is a multifactorial disease that drives tear film instability and hyperosmolarity, directly damaging the ocular surface epithelium. Lysophosphatidic acid receptor (LPAR) is a G-protein coupled receptor (GPCR) responsible for Ca²⁺ and cAMP mobilization via PLC and adenylyl cyclase activation, respectively. LPAR signaling is involved in cell proliferation and wound healing in human corneal epithelial cells (HCECs) as well as in neuropathic pain. This study aims to investigate expression and functional roles of LPAR3 in ocular surface. Ocular surface potential difference (OSPD) and tear fluid volume measurements were performed in mice with topically applied LPAR modulators. …

Administering A Mitophagy Inducing Compound (Mic) To Suppress Neuropathology In A Mouse Model Of Alzheimer’S Disease, Zachary Mayeri

Natural Sciences and Mathematics | Biological Sciences Master's Theses

Despite FDA-approved amyloid-beta (Aβ) therapies in Alzheimer’s disease (AD), Tau pathology remains untreated and is closely linked to cognitive decline. Mitophagy, the process of mitochondrial degradation, is vital for maintaining neuronal health, and its dysregulation is implicated in AD. Recently, our lab identified a mitophagy inducing compound (MIC) that extends the lifespan of C. elegans. We hypothesized that MIC would significantly mitigate neuropathology in an AD mouse model. In this study, aged 3x-Tg AD mice were fed an MIC-containing diet, and immunohistochemistry (IHC) was performed on hippocampal tissue to visualize Aβ and phospho-Tau (pTau) lesions. While MIC had little …

Tiktok On The Clock: It Is Time To Hold Social Media Platforms Responsible For The Dangerous Content They Push To Children, Angelina Rego

The Journal of Business, Entrepreneurship & the Law

This article examines the unresolved issue of social media companies endangering children through their targeted algorithms in a world where Section 230 protects them from any consequences. Part II will provide background on harmful content, like viral challenges, plaguing social media and endangering children. In addition, Part II will present an overview of Section 230’s immunity and its very limited exceptions. Next, Part III will analyze the legislative intent behind Section 230 and its relation to the First Amendment, highlighting that protecting children aligns with the act’s original purpose. Then, Part IV will discuss the few alternative workarounds available to …

Current Status, Public Health Implications, And Potential Future Establishment Of Amblyomma Americanum, The Lone Star Tick, In Maine, Charles Lubelczyk, Molly Meagher, Curtis Bartiromo

Journal of Maine Medical Center

Introduction: Amblyomma americanum is a medically important tick species established in the southeastern United States, with populations gradually spreading northward into New England. This study aimed to evaluate the current presence, distribution, and density of A. americanum in Maine.

Methods: Surveillance efforts focused on Ixodes scapularis have been conducted by the Vector-Borne Disease Laboratory of MaineHealth Institute for Research since 1989. This surveillance uses tick flagging, examination of hunter-harvested game and trapped wild hosts for feeding ticks, and a statewide passive surveillance program. Effort focused on A. americanum surveillance began in 2019 using flagging, carbon dioxide-baited trapping, and serosurveillance (Heartland …

Passive Tick Surveillance At The University Of Maine Cooperative Extension Tick Lab: A 6 Year Retrospective, Thomas F. Rounsville, Griffin M. Dill, Ann M. Bryant, Alyssa G. Marini, Alaina C. Woods, John S. Nugent, Olivia N. Choi, James F. Dill

Journal of Maine Medical Center

Introduction: Maine has experienced a rise in tick-borne diseases over the past several decades, reflecting broader trends in the northeastern United States. Ixodes scapularis is now found statewide and is the primary vector of Borrelia burgdorferi, Anaplasma phagocytophilum, Babesia microti, Borrelia miyamotoi, and Powassan virus. Other emerging tick species pose additional threats.

Methods: The University of Maine Cooperative Extension Tick Lab conducts a public tick-testing program. Ticks submitted by the public between 2019 and 2024 were microscopically identified and tested with multiplex quantitative polymerase chain reaction and reverse transcription-quantitative polymerase chain reaction panels for known and emerging pathogens, including B. …

Ulceroglandular Tularemia In A Pediatric Patient In Maine After A Trip To Martha’S Vineyard, Calvin Schaffer, Kevin Burke, Amanda Goddard

Journal of Maine Medical Center

Introduction: Vector-borne lymphadenitis in children is uncommon. A detailed exposure and travel history can facilitate diagnosis.

Clinical Findings: The pediatric inpatient service admitted a 6-year-old patient after multiple acute care visits for right posterior auricular tenderness, erythema, and swelling.

Clinical Course: Upon admission, the patient received intravenous ceftriaxone and clindamycin for progressive suppurative lymphadenitis. After a review of the patient’s history, which included the removal of an engorged tick and recent travel to Martha’s Vineyard, Massachusetts, the treatment was transitioned to intravenous gentamicin for ulceroglandular tularemia.

Conclusions: Francisella tularensis can be transmitted via tick and deer-fly bites and should be …

Effect Of Application Time On The Efficacy Of Trichoderma Spp. To Biologically Control Sunflower Charcoal Rot, Ahmed M. Samy, Amer F. Mahmoud, Osama A. Abdalla

Sultan Qaboos University Journal For Science

Sunflower (Helianthus annuus L.) is considered as one of the most important oilseed crops in Egypt and worldwide. It is being infected with many pathogens, among these pathogens Macrophomina phaseolina (Tassi) Goid, the causal agent of charcoal rot is the most prevalent one, and responsible for severe economic losses on sunflower production. Fourteen isolates of M. phaseolina were collected from naturally infected sunflower plants. Pathogenicity tests revealed that tested isolates varied significantly in their pathogenic capabilities. But all of the tested isolates were pathogenic and incited the symptoms of pre- and post-emergence damping-off as well as symptoms of charcoal rot. …

Assessment Of The Physicochemical Properties And Antioxidant Content In A Variety Of Omani Honey Samples, Haider A. J. Al Lawati, Javad Hassanzadeh, Nafiseh Bagheri, Muadh Al Shaidi, Majid Al Amri, Hassan Talib M. Al Lawati

Sultan Qaboos University Journal For Science

Honey, a natural product with effective medicinal properties and exceptional energy content, holds a significant place in the hearts of consumers. This study evaluated the pH, free acidity, conductivity, sugar composition, and total antioxidant content of eight types of rare honey produced in Oman. Additionally, well-known types of honey such as Sidr and Sumur, along with some commercial honey samples, were studied for comparison purposes. A simple and innovative paper-based analytical device, recently developed by our group, was applied as an appropriate alternative to time-consuming chromatography-based methods. The findings revealed a low sugar content in a type of honey called …

Ion-Dna Interactions As A Key Determinant Of Uracil Dna Glycosylase Activity., Sharon N Greenwood, Alexis N Dispensa, Matthew Wang, Justin R Bauer, Timothy D Vaden, Zhiwei Liu, Brian P Weiser

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Because of their ubiquitous presence, ions interact with numerous macromolecules in the cell and affect critical biological processes. Here, we discuss how cations including Mg²⁺ alter the enzymatic activity of a DNA glycosylase by tuning its affinity for DNA. The response of uracil DNA glycosylase (UNG2) to Mg²⁺ ions in solution is biphasic and paradoxical, where low concentrations of the ion stimulate the enzyme, but high concentrations inhibit the enzyme. We analyzed this phenomenon by modeling experimental data with a statistical framework that we empirically derived to understand molecular systems that display biphasic behaviors. Parameters from our statistical …

Ciccolella, Peg Oral History Interview, Margaret E. Ciccolella, Gene Pearson

Emeriti Society Oral History Collection

Peg Ciccolella (1985-2024) Professor of Health and Exercise Science.

Health and Exercise Science program development and change, Pacific Legal Scholars program development, chairing of and involvement in Pacific committees, chairing of health and exercise science department, the law and application to health sciences, research and publishing at Pacific, WASC accreditation, change and application of Title IX.

Functionalizing Polyethersulfone Membranes: Using Nmr To Avoid Pitfalls When Using Uv-Induced Polymerization To 'Graft From' Surfaces, Priyanka Suresh, Megan M. Sibley, Amy C. Che, Christine E. Duval

Faculty Scholarship

For nearly 30 years, UV-induced free radical polymerization has been used to modify the surface chemistry of polyethersulfone (PES) membranes, films, and coatings. The initial mechanism for the grafting process was introduced in the 1990s and supported without direct evidence of covalent bond formation. Since then, claims of ‘grafting from’ membranes in the literature rely on similar evidence using a combination of gravimetry, attenuated total reflectance infrared spectroscopy, contact angle goniometry, water sorption, and/or water permeance. While these techniques provide evidence of the presence of a polymer coating, they do not provide direct evidence of covalent bond formation between the …

Effect Of Anesthesia And Diurnal Variation On Chronic Vagus Nerve Activity In Rats, Bhanu P. Kotamraju, Grant A. Mccallum, Dominique M. Durand

Faculty Scholarship

The vagus nerve, serving as a pivotal link between the brain and vital organs, regulates crucial physiological functions. It plays a central role in maintaining homeostasis within the body and must dynamically adapt to changing conditions such as anesthesia or sleep. While vagal tone, typically estimated indirectly from heart rate variability, has been extensively studied, direct measurement of vagal activity during sleep and anesthesia remains unreported to date. Recent technological advancements have facilitated the recording of vagus nerve activity in freely moving rodents using small, highly flexible carbon nanotube yarns. Consequently, it is now feasible to directly investigate vagal activity …

Addition Of Biochar To Anaerobic Digestion Of Food Waste In A Uasb Reactor To Enhance Biogas Production, Michell Ortiz, Farid . Chejne, Andrea . Tamayo, Juan-Diego Otalora

Bio-Char IV

Please click Additional Files below to see the full abstract

Caspase-11 Drives Macrophage Hyperinflammation In Models Of Polg-Related Mitochondrial Disease., Jordyn J Vanportfliet, Yuanjiu Lei, Muthumeena Ramanathan, Camila Guerra Martinez, Jessica Wong, Tim J Stodola, Brian Hoffmann, Kathryn Pflug, Raquel Sitcheran, Stephen C. Kneeland, Stephen A Murray, Peter J Mcguire, Carolyn L Cannon, A Phillip West

Faculty Research 2025

Mitochondrial diseases (MtD) represent a significant public health challenge due to their heterogenous clinical presentation, often severe and progressive symptoms, and lack of effective therapies. Environmental exposures, such bacterial and viral infection, can further compromise mitochondrial function and exacerbate the progression of MtD. However, the underlying immune alterations that enhance immunopathology in MtD remain unclear. Here we employ in vitro and in vivo approaches to clarify the molecular and cellular basis for innate immune hyperactivity in models of polymerase gamma (Polg)-related MtD. We reveal that type I interferon (IFN-I)-mediated upregulation of caspase-11 and guanylate-binding proteins (GBP) increase macrophage sensing of …

Executive Committee - Agenda, 5/20/2025, Academic Senate

Academic Senate Agendas

No abstract provided.

Factors Impacting The Variability Of Post-Fire Forest Regeneration In Central European Pine Plantations, Florent Jouy, Maren Schüle, Yojana Adhikari, Anja Binder, Danica Clerc, Werner Gerwin, Thilo Heinken, Thomas Raab, Frank Repmann, Susanne Rönnefarth, Marina Schirrmacher, Marie-Therese Schmehl, Jens Schröder, Pierre L. Ibisch

Aspen Bibliography

Fire is increasingly posing a risk to forests and plantations, even in the temperate latitudes of central Europe. Little is known about fire ecology in this region, and therefore, appropriate approaches for the management and reforestation of burned sites are mostly lacking. In a Scots pine plantation region in Brandenburg (northeast Germany), the early tree regeneration of two nearby areas that burned 1 year apart was investigated. We observed that 3 years after the fire events, the forest in one study area showed a relatively high regeneration with a mean density of 7765 saplings/ha, clearly dominated by European aspen (93%); …

Unforeseen Implications Of Assisted Reproductive Technology Post-Dobbs, Isabele M. Castle

University of Dayton Law Review

No abstract provided.

Network Analysis Of Antimicrobial Resistance In Staphylococcus Aureus: Characterization Of Hub Genes And Their Functional Implications, Md Imran Hasan, Davida Smyth, Jeong Yang, Ashley Teufel

Masters Theses (Archived)

Antimicrobial resistance is a major cause of morbidity and mortality in patients with S. aureus infections. In this study, we analyzed genes, molecular mechanisms, and pathways driving drug resistance in S. aureus using network analysis. Using whole-genome sequencing (WGS) data and systems biology approaches, we identified 229 AMR-associated genes and constructed a protein-protein interaction network among these genes. Through network topology and functional enrichment analyses, we not only confirmed their association with resistance, but also highlighted the central roles of these genes in resistance pathways, such as efflux, target replacement, and target protection, which are directly linked to multiple drug …

Biochar: A Strategic And Integral Component For The Viability Of Biorefineries In Colombia, Carlos M Ceballos, Juan . Carlos Maya, Farid Chejne Janna

Bio-Char IV

Please click Additional Files below to see the full abstract

Unlocking Musculoskeletal Anatomy: Enhancing Second-Year Medical Students’ Knowledge Recall And Self-Efficacy With A Physician-Led Ultrasound Session, Nathan Cowan, Abdus Sattar, Qian Wu, Allison N. Schroeder

Faculty Scholarship

Introduction: The purpose of this study was to determine whether exposure to musculoskeletal (MSK) ultrasound (US) enhanced medical students’ knowledge and self-efficacy in understanding basic US principles, MSK anatomy and physical examination, and use of US to evaluate MSK structures. Materials and Methods: Forty-three second-year medical students were divided into control (n = 22) and experimental (n = 21) groups. All participants completed a pre-session self-efficacy questionnaire and were encouraged to view a recorded 20-min MSK US lecture. All participants then attended a physician-led 35-min MSK US hands-on scanning session covering the shoulder and knee. The control group took a …

Historical Perspectives In Volatility Forecasting Methods With Machine Learning, Zhiang Qiu, Clemens Kownatzki, Fabien Scalzo, Eun Sang Cha

All Faculty Open Access Publications

Volatility forecasting for financial institutions plays a pivotal role across a wide range of domains, such as risk management, option pricing, and market making. For instance, banks can incorporate volatility forecasts into stress testing frameworks to ensure they are holding sufficient capital during extreme market conditions. However, volatility forecasting is challenging because volatility can only be estimated, and different factors influence volatility, ranging from macroeconomic indicators to investor sentiments. While recent works show promising advances in machine learning and artificial intelligence for volatility forecasting, a comprehensive assessment of current statistical and learning-based methods is lacking. Thus, this paper aims to …

Monitoring Reaction Kinetics In Alternative Cementitious Systems Through Electrical Conductivity Measurements, Julson Aymard Tchio, Elijah Adesanya, Rafal Sliz, Brant Walkley, Juho Yliniemi

Alkali Activated Materials and Geopolymers: High-end technical applications [2025]

Please click Additional Files below to see the full abstract

International Changemaker Grant Sends Students To Work In Global Communities, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.