Digital Commons Network^™

Synthesis Of Hydroxyapatite-Zirconia Composite And Activity Test As Dental Implant Material, Atiek Rostika Noviyanti, Difa Muhammad Yashfi, Yusi Deawati, Eneng Maryani, Sabila Aulia Hemzah, Azman Ma’Amor

Chimica et Natura Acta

Hydroxyapatite (HAp) is one of the bioceramics that is widely used in various fields, one of which is the health sector as a dental implant material. One of the reasons is that hydroxyapatite has good biocompatibility. In this study, natural calcium sources such as eggshell waste were utilized for the synthesis of hydroxyapatite. However, its mechanical properties do not yet meet the requirements as a dental implant material, its modification is usually done by adding other compounds, such as zirconium oxide. Zirconium oxide can be used as a support material because it has good strength, toughness, and durability as a …

Silver Star: The Superheroine Love Of My Life, Primo C. Murillo Jr.

Master's Projects

Silver Star: The Superheroine Love of My Life is a new adult, queer romance novel about a pair of young women living in a modern world filled with superheroes. This manuscript covers the first five chapters of this proposed novel, which is still in development. The story follows Freddie Silang, a Filipina-American superhero fan with no superpowers, who struggles to find her place in life after college. Freddie's mundane life is forever changed, however, when she meets her favorite superhero, Ms. Metropolis, during a battle against a minor villain. After Freddie saves Ms. Metropolis in an impulsive, yet selfless act, …

Effects Of Acute Exercise On Cognition: Consideration Of Potential Moderators, Elizabeth G. Gaines, Mckenzie M. Cotten, Elizabeth Reese Carwile, Mary Griffin Jackson, Marascalco Liston, Lucy Wilson

Honors Theses

The present thesis aims to determine the effects, if any, of six potential moderators on the effects of acute moderate-intensity exercise on cognitive functioning. The modes of exercise undertaken by the participants included treadmill (Experiment 1) and stationary bike (Experiment 2) exercise. Participants in each experiment either exercised or rested for twenty minutes and then participated in either a memory recall task or cognitive functioning (“Stroop”) task. The bouts of either exercise or rest on the stationary bike were followed by a rest period during which the participant would be exposed to either standard air oxygen levels (normoxia) or hypoxic …

The Potential Of Brain Organoids In Addressing The Heterogeneity Of Synucleinopathies, Xiao-Jun Diao, Claudio Soto, Fei Wang, Yu Wang, Yun-Cheng Wu, Abhisek Mukherjee

Faculty, Staff and Student Publications

Synucleinopathies are a group of diseases characterized by neuronal and glial accumulation of α-synuclein (aSyn) linked with different clinical presentations, including Parkinson's disease (PD), Parkinson's disease with dementia (PDD), Dementia with Lewy Bodies (DLB) and Multiple system atrophy (MSA). Interestingly, the structure of the aSyn aggregates can vary across different synucleinopathies. Currently, it is unclear how the aSyn protein can aggregate into diverse structures and affect distinct cell types and various brain regions, leading to different clinical symptoms. Recent advances in induced pluripotent stem cells (iPSCs)-based brain organoids (BOs) technology provide an unprecedented opportunity to define the etiology of synucleinopathies …

Investigative Needle Core Biopsies Support Multimodal Deep-Data Generation In Glioblastoma, Kenny K H Yu, Sreyashi Basu, Gerard Baquer, Ryuhjin Ahn, Jennifer Gantchev, Sonali Jindal, Michael S Regan, Zaki Abou-Mrad, Michael C Prabhu, Marc J Williams, Alicia D D'Souza, Seth W Malinowski, Kelsey Hopland, Yuval Elhanati, Sylwia A Stopka, Alexei Stortchevoi, Charles Couturier, Zhong He, Jingjing Sun, Yulong Chen, Alexsandra B Espejo, Kin Hoe Chow, Smitha Yerrum, Pei-Lun Kao, Brittany Parker Kerrigan, Lisa Norberg, Douglas Nielsen, Vinay K Puduvalli, Jason Huse, Rameen Beroukhim, Betty Y S Kim, Sangeeta Goswami, Adrienne Boire, Sarah Frisken, Michael J Cima, Matthias Holdhoff, Calixto-Hope G Lucas, Chetan Bettegowda, Stuart S Levine, Tejus A Bale, Cameron Brennan, David A Reardon, Frederick F Lang, E Antonio Chiocca, Keith L Ligon, Forest M White, Padmanee Sharma, Viviane Tabar, Nathalie Y R Agar

Faculty, Staff and Student Publications

Glioblastoma (GBM) is an aggressive primary brain cancer with few effective therapies. Stereotactic needle biopsies are routinely used for diagnosis; however, the feasibility and utility of investigative biopsies to monitor treatment response remains ill-defined. Here, we demonstrate the depth of data generation possible from routine stereotactic needle core biopsies and perform highly resolved multi-omics analyses, including single-cell RNA sequencing, spatial transcriptomics, metabolomics, proteomics, phosphoproteomics, T-cell clonotype analysis, and MHC Class I immunopeptidomics on standard biopsy tissue obtained intra-operatively. We also examine biopsies taken from different locations and provide a framework for measuring spatial and genomic heterogeneity. Finally, we investigate the …

Intracellular And Extracellular Activities Of V-Domain Ig-Containing Suppressor Of T Cell Activation (Vista) Modulated By Immunosuppressive Factors Of Tumour Microenvironment, Maryam Abooali, Stephanie Schlichtner, Xi Lei, Nijas Aliu, Sabrina Ruggiero, Sonia Loges, Martin Ziegler, Franziska Hertel, Anna-Lena Volckmar, Albrecht Stenzinger, Petros Christopoulos, Michael Thomas, Elena Klenova, N Helge Meyer, Stergios Boussios, Nigel Heaton, Yoh Zen, Ane Zamalloa, Shilpa Chokshi, Luca Urbani, Sophie Richard, Kavitha Kirubendran, Rohanah Hussain, Giuliano Siligardi, Dietmar Cholewa, Steffen M Berger, Inna M Yasinska, Elizaveta Fasler-Kan, Vadim V Sumbayev

Peninsula Medical School

V-domain Ig-containing suppressor of T cell activation (VISTA) is a unique immune checkpoint protein, which was reported to display both receptor and ligand activities. However, the mechanisms of regulation of VISTA activity and functions by factors of tumour microenvironment (TME) remain unclear and understanding these processes is required in order to develop successful personalised cancer immunotherapeutic strategies and approaches. Here we report for the very first time that VISTA interacts with another immune checkpoint protein galectin-9 inside the cell most likely facilitating its interaction with TGF-β-activated kinase 1 (TAK1). This process is required for protection of lysosomes, which is crucial …

Stability Analysis Of Excessive Carbon Dioxide Gas Emission Model Through Following Reforestation Policy In Low-Density Forest Biomass, Furqan Nezar, Shireen Jawad, Matthias Winter, Anwar Zeb

Baghdad Science Journal

Carbon dioxide is the main greenhouse gas contributing to global warming risk. Forest biomass is crucial for the sequestration of atmospheric carbon dioxide; however, the rate of decline in worldwide forest biomass is concerning and can be attributed to anthropogenic activities. Reforestation is essential in this situation to decrease the amount of C O₂ in the atmosphere. Efforts at reforestation can be evaluated according to the financial investment required for their execution. This work presents a nonlinear mathematical model that examines the impact of reforestation and the implementation of reforestation initiatives on regulating atmospheric CO₂ levels. The critical …

Fractal Dimension And Entropy Analysis Of Medical Images For Knn-Based Disease Classification, Krishna Mahapatra, Selvakumar R

Baghdad Science Journal

The study of medical image-based disease detection has witnessed a notable surge in interest and success with computational methods. This work proposes a novel framework to detect diseases at earlier stages from medical images, using mathematical model and Machine Learning. Introduce two new quantitative measures for COVID-19 and Tumor disease detection: image uncertainty based on Shannon entropy and image complexity based on fractal dimension. Our result demonstrated that in COVID-19 positive images exhibited skewed pixel distribution due to the hazy regions resulting in lower entropy values for diseased cases compared to healthy ones. The second quantity, fractal dimension was measured …

Facebook Comments-Based Assessment Model For Food Product Companies Using Four Machine Learning Methods With Arabic/Iraqi Lexicon, Raad Sadi Aziz, Sura Mazin Ali, Ahmed T. Sadiq

Baghdad Science Journal

People's need for food is increasing day after day due to the large population increase that has occurred in human society, which has led to a significant increase in the activity of food product manufacturing companies in the world. Hence the necessary need to evaluate the performance of food production companies. We found that the best way to evaluate the performance of these companies is through social media comments, because it is the newest and most common method among people. In this paper, 4 machine learning techniques were relied upon to evaluate participants' comments in evaluating food production companies after …

Daddy’S Little Girl: The Role Of Life History In Paternal Investment Towards Daughters, Ray Garza, Emily Woolman, Sepide Pazhouhi, Farid Pazhoohi

School of Psychology

ObjectivesThis study examines the complex dynamics of father-daughter relationships, focusing on how life history factors are associated with paternal behaviors towards daughters. Drawing on Life history Theory and the Daughter-Guarding hypothesis, the research investigates how these factors contribute to father-daughter interactions, such as attachment, protection, support, and control received from fathers.MethodsTwo surveys were conducted: one with 120 daughters aged 18–21 (Study 1) and another with 120 fathers (Study 2), both recruited through online platforms. Study 1 examined the relationship from the daughters’ perspective, while Study 2 explored it from the fathers’ perspective.ResultsFathers with higher education and stable financial backgrounds showed …

Quantifying Treatment Response To A Macrophage-Targeted Therapy In Combination With Immune Checkpoint Inhibitors After Exposure To Conventional Chemotherapy, Shelby N. Bess, Gaven K. Smart, Timothy J. Muldoon

Biomedical Engineering Faculty Publications and Presentations

Background: Conventional chemotherapeutic agents, such as 5-fluorouracil (5-FU), can exert anti-tumor effects through immunogenic cell death (ICD) induction. Researchers have found hallmarks that quantify ICD (such as the translocation of HMGB1 and calreticulin). Although chemotherapeutic agents can induce ICD, they increase the expression of immune checkpoints, limiting their effectiveness. Studies have emphasized the importance of investigating the heterogeneous responses of cells co-localized in a solid tumor (macrophages, tumor cells, etc.) to ICD induction. However, these studies were performed in vivo, which limits the collection of information on cell-cell interactions due to model complexity.

Methods: In this study, we used a …

Mine Closure Planning Must Face The Challenge Of Delivering Nature Positive Outcomes, Luis E. Sanchez, Angus Morrison-Saunders

Research outputs 2022 to 2026

The need to address and reverse global biodiversity decline is imperative across all of society including the practices of mine closure planning. Nature Positive is the latest global biodiversity-focused initiative which calls for at least 30% of biodiversity to be enhanced through effective restoration relative to the 2020 baseline. This paper conceptualizes and explains what is necessary in mine closure planning and implementation to meaningfully contribute to this and other nature-positive goals, with some illustrative examples. Issues considered include application of the mitigation hierarchy, rehabilitation in mining and the time lag challenge for restoring biodiversity, biodiversity offsetting, conserving nature while …

Patient-Generated Health Data: Impact On Promoting Patient-Centered Point Of Care Tobacco Treatment In Patients With Cancer, Jessica Liu, Jingling Chen, Nina Smock, Nicholas B Griffith, Ramaswamy Govindan, Paula Goldberg, Jodi Thole, Kristin Daly, James Reddy, Alex T Ramsey, Laura J Bierut, Aimee James, Robert A Schnoll, Ross C Brownson, Li-Shiun Chen, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Guideline-based tobacco treatment is infrequently offered. Electronic health record-enabled patient-generated health data (PGHD) has the potential to increase patient treatment engagement and satisfaction.

METHODS: We evaluated outcomes of a strategy to enable PGHD in a medical oncology clinic from July 1, 2021 to December 31, 2022. Among 12,777 patients, 82.1% received a tobacco screener about use and interest in treatment as part of eCheck-in via the patient portal.

RESULTS: We attained a broad reach (82.1%) and moderate response rate (30.9%) for this low-burden PGHD strategy. Patients reporting current smoking (

DISCUSSION: PGHD via patient portal appears to be a …

Employability Of International Postgraduate Taught Students In The Uk: A Systematic Literature Review Using Prisma, Fa Wang, Rong Huang, Jingyu Wu, Wai Mun Lim

Plymouth Business School

One-year postgraduate taught programmes in the UK attract global talent through high-quality education, yet the employability and career pathways of these students remain understudied despite their recognised vital economic and cultural contributions. Amid the UK's higher education financial crisis, marked by funding cuts, staff layoffs, rising costs, and reliance on international student recruitment, this study employs the PRISMA 2020 framework to systematically review literature (2014–2024) on international postgraduate taught student employability. Analysing 13 studies from Web of Science, Scopus, and Google Scholar, the findings reveal gaps in tailored sector-specific career and employability support, access to employment development opportunities and work-integrated …

Dental Morphology And Pathology Of Middle Bronze Age Populations In Israel: Sasa And Jebel Qa‘Aqir, Benjamin Peretz, Patricia Smith

'Atiqot

No abstract provided.

Middle Bronze Age Ii Burials At Sasa, Upper Galilee (Tomb 1 And Graves 37, 39), Patricia Smith

'Atiqot

No abstract provided.

Roman-Period Burial Caves On The Slopes Of Mount Carmel: An Anthropological Study, Yossi Nagar

'Atiqot

No abstract provided.

A Mother And Child Reunion? An Unusual Ottoman-Period Bedouin Pit Grave At Rahat, The Northern Negev, Yossi Nagar, Noé David Michael, Oren Shmueli, Elena Kogan-Zehavi

'Atiqot

No abstract provided.

Making The Invisible Visible: Burial Customs In Late Roman–Byzantine-Period Western Galilee, Based On Organic Remains Adhering To Metal Objects, Ádám Bollók, Ayelet Dayan, Naama Sukenik

'Atiqot

No abstract provided.

Visible And Invisible Deathscapes Of Iron Age Philistia, Aren M. Maeir, Philipp W. Stockhammer

'Atiqot

No abstract provided.

Gastrointestinal Helminth Parasites Of Heterotis Niloticus (Osteoglossiformes: Osteoglossidae) From Anambra River, Eastern Nigeria, Comfort Chidiogo Nwadike, Ebube Charles Amaechi, Philip Chijioke Okoye Ilozumba

Sultan Qaboos University Journal For Science

Fish diseases especially those caused by parasites are major problems confronting fish farmers globally. This study investigated the gastrointestinal helminth parasites of Heterotis niloticus (African Bony tongue fish) from the Anambra River basin over 12 months (January to December, 2013). A total of 294 fish were caught from three locations along the Anambra River, and transported to the laboratory for morphological and parasitological studies. Four species of helminth parasites were isolated comprising one cestode (Sandonella sandoni), two nematodes (Procamallanus laeviconchus and Dujardinascaris species) and one acanthocephalan (Tenuisentis niloticus). Out of the 294 fish species examined, the overall prevalence of infection …

Incidence Of Urinary Tract Infections, Etiological Agents, And Antibiotic Susceptibility Among Pregnant And Non-Pregnant Women In Amedi Region, Iraq, Nabi Qadri Saeed, Nedim Çakir, Mahde Saleh Assafi

Sultan Qaboos University Journal For Science

Urinary tract infection is a bacterial infection caused by bacteria from the digestive tract entering the urinary tract. It is more prevalent in women and remains the most common bacterial infection in humans. The study aimed to assess the prevalence of urinary tract infections (UTIs) in pregnant women, identify and diagnose uropathogenic bacteria, and examine the antibiotic susceptibility of the isolated bacteria. A total of 283 urine specimens were collected from pregnant and non-pregnant females of different ages who visited Amedi hospital between October 2020 and January 2021. The samples were cultured and incubated on Blood agar and MacConkey agar …

Emergence Rhythms And First Larval Stage Description Of The Crab Chiromantes Boulengeri (Calman) From Shatt Al-Arab, Basrah, Iraq, Malik H. Ali, Salman D. Salman, Huda K. Ahmed, Hanaa H. Mohammed

Sultan Qaboos University Journal For Science

The rhythmic behavior of emergence (locomotion) activity outside the burrows of the crab Chiromantes boulengeri (Calman) collected from the intertidal habitat of Shatt Al-Arab River, Basrah, Iraq was studied in the laboratory, with three light regimes (using 10 adult crabs, for 5 consecutive days for each light regime). Under natural illumination (daytime: night-time) the study revealed that the crabs exhibited high locomotor activity (M= 7.1 ind.) during the daytime that was significantly higher than the night-time (M= 4.1 ind.). The result showed no relationship between the locomotor activity of the crabs and the two daily tidal cycles as the two …

The Effectiveness Of Some Safety Compounds In Controlling Botrytis Neck Rot Of Onion, Naglaa G. Ahmed, Hassan A. Gouda, Mahmoud A.A. Rashwan

Sultan Qaboos University Journal For Science

Onion (Allium cepa L.) is one of the major vegetable crops in Egypt that are damaged and lost by Botrytis neck rot. The aim of this study was to determine the efficacy of silica gel, acetic acid, fulvic acid and charcoal as protective agents against Botrytis allii under both in vitro and in greenhouse and field conditions. In vitro, the maximum disease reduction was observed by 1%, 0.8% and 0.5% acetic acid (73.7%, 63.7%, and 61.2%, respectively), followed by 2% of charcoal (52%) and 3% of silica gel (47.5%). In the greenhouse and field conditions, silica gel (3%) and acetic …

Determination Of Norfloxacin In Tablets And Biological Fluids Using Terbium-Caffeine Coordination Polymer Luminescence, Shaima Al-Salhi, Saleh Al-Busafi, Beena Verghese, Salma M. Al-Kindy, Fakhreldin O. Suliman, Rengaraj Selvaraj

Sultan Qaboos University Journal For Science

The usefulness of caffeine (CF) as a chelating agent to increase the luminescence intensity of terbium (Tb3+) was studied. The efficiency of the developed Tb3+/CF- coordination nanoparticles was evaluated as a sensing platform for the detection of fluoroquinolone antibiotics, using norfloxacin (NF) as a model analyte. The luminescence conditions of Tb3+/CF-NF were investigated and optimized. Under the optimized experimental conditions, the linearity of the method was established with a limit of detection (LOD) of 5.8 nM, and the effect of some expected interferes was examined. The developed method was successfully applied for the detection of norfloxacin in tablet and urine …

Isolation Of Digeranyl From The Hexane Extract Of Moringa Peregrina Leaves, Saleh N. Al-Busafi, Safiya A. Al-Jabri, Shareef Al-Hashmi

Sultan Qaboos University Journal For Science

The plant kingdom provides many precious gifts to mankind. One of these gifts is its ability to produce an endless stream of natural products. Moringa peregrina (In Oman called Al Shua) provides a wide range of benefits to traditional medicine in many cultures, as well many nutritional values. This paper discusses the isolation, and purification of digeranyl from the hexane extract of Moringa peregrine’s leaves, for the first time. Recent studies show that digeranyl phosphate derivative, digeranyl bisphosphonate, inhibits breast cancer cell migration by inhibiting geranylgeranyl diphosphate synthase (GGDPS). The structure of the isolated compound has been confirmed using different …

Effect Of Seawater Irrigation On Germination Seed Of Ceratonia Siliqua L. And Their Treatment With Seaweed Extracts, Ahmed Amrajaa Abdulrraziqb, Sami Mohammed Salih, Abdoun Hashim Alwan

Sultan Qaboos University Journal For Science

The Libyan coasts provide a diverse environment with many seaweeds that are unstudied. The present study was conducted with the aim of evaluating the effect of irrigation with seawater at several concentrations (0, 10, 20, 30and 40%) on the germination of seeds of Ceratonia siliqua L. (wild and cultivated), and treatment by pre-soaking for 24 h at a concentration 10% of three species of seaweed extracts (Padina pavonica, Sargassum vulgare, and Posidonia oceanica ). The results showed that C. siliqua seeds were able to germinate under until a concentration of 30% by a germination percentage (18%). Generally, salinity stresses significantly …

The Allelopathic Effects Of Persicaria Salicifolia On The Growth And Antioxidant Enzymes Of Synechocystis Pevalekii And Tetradesmus Bernardii, Mustafa A. Fawzy, Mahmoud S. Adam, Arwa A. Al-Badaani, Awatief F. Hifney, Sedky H.A. Hassan

Sultan Qaboos University Journal For Science

In recent years, there has been an increasing focus on the prospect of exploiting macrophytes as an alternative strategy to control undesired algal growth. The present research was conducted to study the effect of different concentrations of an aqueous stem extract of Persicaria salicifolia on the growth, some metabolites and antioxidant enzymes of the green microalgae Synechocystis pevalekii and Tetradesmus bernardii. Chlorophyll a, dry weight, total protein, total carbohydrate and proline contents of the tested algae decreased with increasing the crude extract concentrations of P. salicifolia. In general, catalase, superoxide dismutase and lipoxygenase activity of T. bernardii increased with increasing …

Effects Of Microplastic On The Gastrointestinal Tract And Gut Microbiome Of Sprague Dawley Rats, Taher Baomar, Zahra Al-Mahrooqi, Michael J. Barry, Aziz Al-Habsi, Raeid M.M. Abed

Sultan Qaboos University Journal For Science

ABSTRACT Nowadays there is evidence that animals are exposed to microplastics (MPs) via food, however there is not much known about their effect on tissue of gastrointestinal tract and on gut microbiome. In this study, adult male rats were fed with polyethylene MPs, mixed with standard pellet food for 24 days at different concentrations ranging from 0 to 1000 μg/day. At the end of experiment, rats were euthanized and histopathological investigation using light and electron microscopy and the gut microbiome was analyzed using MiSeq 16S rRNA amplicon sequencing. Microscopic analysis revealed significant impact of MPs on the intestine, including visible …

A Census Of Lakes In Gandaki Province Based On Remote Sensing, Anup Gurung, Bindu Malla Thakuri, Saroj Panthi, Kripa Pokhrel, Rana Bahadur B.K, Shiva Pariyar, Nischal Sedhai, Arbin Poudel, Bipin Poudel, Maheswar Dhakal

Sultan Qaboos University Journal For Science

Lakes in Nepal play a crucial role in supporting biodiversity conservation, regulating ecosystems, and providing livelihood opportunities for local communities. Many lakes in Nepal hold immense religious and cultural significance for the local community, serving as sacred pilgrimage sites and embodying spiritual entities that are integral to the traditions, beliefs, and practices of the people, making them important cultural landmarks of the country. Despite their significance and importance, lakes in Nepal have faced degradation and challenges. Due to inappropriate infrastructure development, encroachment, and anthropogenic activities, lakes are degraded in Nepal. In recent years, Gandaki Province also witnessed the degradation of …