Digital Commons Network^™

Bayesian Model Updating Of Structural Parameters Using Temperature Variation Data., Ujjwal Adhikari

Electronic Theses and Dissertations

Physical digital twins have now emerged as a technology in structural health monitoring and other domains of structural modeling. A Finite Element Model can be a tool for digital twin technology in conjunction with measured physical data. Developing an accurate digital model requires the integration of various parameters to replicate the real structure; however, temperature is dynamically changing, resulting in difficulty in the identification of structural parameters. Typically, temperature is considered noise or filtered out. Limited research has addressed the physics-based model using temperature variation related to structural modal properties. Finite Element Model Updating (FEMU) is a typical inverse problem-solving …

Mechanisms Of Particulate Hexavalent Chromium-Induced Inhibition Of Homologous Recombination Repair: Targeting The Bcdx2 Complex Considered Through A One Health Perspective., Aggie W. Brownell

Electronic Theses and Dissertations

Lung cancer remains the leading cause of cancer death, often linked to smoking. However, smoking alone does not account for all cases. Exposure to environmental metals like hexavalent chromium [Cr(VI)] also contributes to lung cancer. Cr(VI) causes lung cancer by inducing chromosome instability (CIN), an early hallmark of its carcinogenic mechanism. While it has been established that Cr(VI) induces chromosome instability, the precise mechanisms underlying the chromosome instability are poorly understood. This dissertation investigates the mechanisms of carcinogenesis associated with zinc chromate, a particularly potent particulate form of hexavalent chromium. Studies show Cr(VI) induces DNA double-strand breaks and impairs the …

Catholic High School Principals’ Experiences With Parent-School Relationships And Perceptions Of Self-Efficacy., Alexander J. Glaser

Electronic Theses and Dissertations

Principals feel overworked in part due to their responsibilities and the demands of the modern educational institution. Furthermore, dynamics between schools and parents are changing in an increasingly polarized climate. Catholic schools face a unique challenge as school choice is more prevalent and client pools become more diverse. Understanding self-efficacy is elemental to building resiliency in principals leading schools in the current climate. Through this mixed-methods phenomenological study, I sought to understand Catholic secondary school principals’ levels of self-efficacy in daily tasks and determine how parent-school relationships explain these perceptions. I used descriptive data and interviews which led to several …

Integration Of Multi-Omics Datasets Evaluating Structural And Functional Features Of The Gut Microbiome In People With Hiv (Pwh)., Aakarsha Vijayakumar Rao

Electronic Theses and Dissertations

Gut dysbiosis characterized by reduced abundance of beneficial butyrate-producing bacteria has been independently linked to HIV-1 infection and heavy alcohol drinking. Further, gut dysbiosis results in loss of gut barrier integrity, microbial translocation and host-specific systemic inflammation. Therefore, to evaluate the functional consequences of structural changes in the gut microbiome, integrated data analysis is imperative. In this dissertation, we perform integrated analyses using data from multi-omics platforms to examine the structural and functional features of the gut microbiome of PWH. Gut microbiome composition was evaluated by sequencing V4 region of 16S rDNA, concentrations of metabolites and host-specific immune markers were …

Differences In Prostate Cancer (Pca) Stage At Primary Diagnosis And Pca-Specific Mortality Among Rural Versus Urban Populations In Kentucky., Chase Herrmann

Electronic Theses and Dissertations

Kentucky Cancer Registry (KCR) prostate cancer (PCa) cases between the years of 1994 and 2021 were analyzed to examine differences between rural and urban populations’ primary stage at diagnosis and PCa-specific mortality. After adjusting for covariates, rural populations did not experience significantly higher odds of stage 3 diagnosis when compared to urban populations (OR = 1.02, 95% CI = 0.95 – 1.06). Rural populations had 16% increased odds of stage 4 diagnosis when compared to urban populations (OR = 1.16, 95% CI = 1.10 – 1.23). Rural populations had a 17% increased rate of PCa-specific death when compared to urban …

The Light Farm., John Wrestling Brewster Clay

Electronic Theses and Dissertations

The Light Farm is a creative examination of the convergence and divergence of truth and meaning, told in a collection of three short stories that both supplements, and is supplemented by a thesis exhibition of fine art. These stories are told using an episodic format that facilitates world building across time periods, while the sculptures, photographs, and text within the exhibition function as a physical entry point into a space in which the line between fact and fiction is tested. The impetus for this project was a lifelong interest in the disorderly confluence of corporatism, power, mortality, morality, human potential, …

Influence Of Terrain Model Resolution On Rockfall Dispersion And Tortuosity Of Rockfall Paths, Lucas Jason Arsenith

Boise State University Theses and Dissertations

The geology of the Snake River Plain region of southwestern Idaho contains terraces formed from downcutting of the Boise River and columnar jointed basalt cliffs from lava flows. Within the city limits of Boise, Idaho, rockfall events originate from these columnar jointed basalt cliffs. Whitney Terrace, a rockfall-prone location in southwestern Boise, was chosen as the study site. Site-specific LiDAR data was used to create a bare earth terrain model, and rockfall boulders were geolocated and measured to be used as inputs into rockfall models. The slope below the cliff face was divided into four distinct slope zones, each with …

Exploring Belonging In Early Childhood Care And Education: Perspectives Of Young Children, Melissa Telford Buck

Boise State University Theses and Dissertations

Belonging is a fundamental human need with significant developmental implications, influencing identity, self-concept, mental health, emotional-wellbeing, and behavior. While school belonging has been widely studied, research on belonging in early childhood care and education (ECCE) settings, particularly from young children’s perspectives, is limited. This multi-case study investigated young children’s perspectives in ECCE settings to determine how they explained the term belonging and to identify key factors contributing to their sense of belonging through photography, tours, discussions, and drawings. Prioritizing cross-case analysis, the findings revealed that young children could explain belonging and articulate specific factors, places, people, or activities as contributors. …

Functional Data Analysis Of Weekly Confirmed Covid-19 Cases Per Million In Relation To Unemployment Rates And Emergency Declaration Responses, Elaina Kay Mcgovern

Boise State University Theses and Dissertations

At the onset of the COVID-19 pandemic, U.S. states implemented policies that attempted to mitigate the spread and effects of the disease, such as a state of emergency declaration. This study explores the application of functional data analysis (FDA) as a means to investigate the impact of U.S. state-level emergency declarations on weekly confirmed COVID-19 cases per million during the first year of the pandemic. We focus on the duration and extent to which proactive states showed significantly different patterns of COVID-19 spread than those that implemented policies reactively. Additionally, we examine patterns in monthly state-level unemployment rates over the …

From Molecular Crystals To Catalytic Surfaces: Computational Approaches To Complex Systems, Thiago Henrique Da Silva

Boise State University Theses and Dissertations

Understanding and modeling complex systems is one of the core challenges in modern science. Whether it be the intricate interactions within molecular crystals, the evolving mechanisms of bacterial resistance, or the dynamics of catalytic surfaces, accurately representing these systems is essential for scientific progress. This dissertation addresses these challenges by focusing on advances in computational modeling, demonstrating how various methods such as Density Functional Theory (DFT), machine learning, and custom-developed methods can simplify and help predict complex behaviors across multiple domains. By applying and understanding the scope of these methods to each field, this work underscores how computational modeling bridges …

Culturing And Characterization Of Arbuscular Mycorrhizal Fungi Native To The Sagebrush Steppe, Jacob Venable

Boise State University Theses and Dissertations

Arbuscular mycorrhizal fungi (AMF) are obligate biotrophs that form symbiotic associations with the roots of over 70% of terrestrial plants. These symbioses are crucial in plant nutrient acquisition, stress tolerance, and soil health. AMF inoculum could be valuable for ecological restoration, but challenges in culturing and multiplying AMF limit their use in natural habitats. In this project, I investigated methods to characterize and culture AMF native to the sagebrush steppe. For comparison, I also grew a non-native strain of the AMF fungus Rhizophagus clarus. First, I used trap cultures to multiply AMF present in roots and field soil collected …

Random Processes With High Variance Produce Scale Free Networks, Josh Johnston

Boise State University Theses and Dissertations

The degree distribution of a real world network --- the number of links per node --- often follows a power law, so some hubs have many more links than traditional graph generation methods predict. For years, preferential attachment and growth have been the proposed mechanisms leading to these scale free networks, exemplified by the Barabási–Albert model. This dissertation provides an alternative model using a randomly stopped linking process, showing that mixtures of geometric distributions can lead to power laws, an intuition suggested by the Central Limit Theorem for distributions with infinite variance. Having a collection of Bernoulli trials with high …

Development Of Soil Water Characteristic Curves Through Control Of Relative Humidity, Lauren E. Johnson, Julia I. Loshelder, Richard A. Coffman

Civil Engineering Undergraduate Honors Theses

The relationship between soil suction and soil water content in unsaturated soil mechanics is important but can be difficult to measure. The objective of the research described herein was to develop soil water characteristic curves (SWCC) from relative humidity values by incorporating the use of glycerin-water mixtures. Glycerin-water mixtures can be used to achieve different relative humidity levels by varying the concentration of glycerin within the mixture. The relative humidity created by each mixture was measured with a relative humidity sensor, and the relative humidity values and Kelvin’s equation were used to compute the total suction.

Soil water characteristic curves …

The Association Of Discrimination, Inflammation, And Coping Style On Self-Rated Health Among South Asian Individuals In The Masala Study, Raji Pillai, Sahiti Myneni, Constance M Johnson, Nilay S Shah, Alka M Kanaya, Jennifer E S Beauchamp

Faculty, Staff and Student Publications

Objectives: South Asian individuals (SAs) may have heightened levels of inflammatory markers, such as C reactive protein (CRP), Tumor Necrosis Factor-α (TNF-α), leptin, and resistin, and decreased levels of anti-inflammatory adiponectin, contributing to higher cardiovascular disease (CVD) incidence. Social determinants of health, like discrimination, are also associated with risks for CVD in SAs. This study examined the associations between discrimination and inflammation and whether coping styles moderated the association between discrimination and self-rated health (SRH) among SAs in the United States.

Design: Secondary analysis of data obtained from 1164 SAs (mean age = 57 years, SD = 9.4, 48% women) …

Empowering Through Technology: An Internship Report On Augmentative And Alternative Communication Devices, Olivia G. Macdonald

Communication Disorders and Occupational Therapy Undergraduate Honors Theses

Augmentative and Alternative Communication (AAC) devices play a crucial role in supporting individuals with communication challenges, particularly children with developmental disabilities such as Autism Spectrum Disorder (ASD). This paper provides a comprehensive review of the literature on AAC and offers a detailed report of an internship experience at the University of Arkansas WE CARE Summer Camp. During the internship, firsthand experiences provided valuable insights into how AAC technologies can be applied to enhance communication, foster social connections, and support behavioral regulation.

The literature review explores the different types of AAC systems, including both aided and unaided options, and discusses the …

Blink-Related Brainwaves As Digital Biomarkers For Cognition Assessment During Complex Tasks, Lexine Carmlixa Sibert-Jolissaint

Theses and Dissertations

Blink-related oscillations (BROs) are neurophysiological responses observed in electroencephalography (EEG) following spontaneous blinking, reflecting the brain processing of new visual information. Prior research has demonstrated BRO responses across various cognitive states, such as resting, cognitive loading, and sensory stimulation, highlighting their potential as a non-invasive biomarker of brain function. We conducted the first investigation of BRO responses during a verbal fluency (VF) task, which is a complex, dynamic task state combining memory, visual perception, executive function, and language processing. Using publicly available EEG data from 22 healthy adults, we measured BRO responses over the left anterior frontal region corresponding to …

The Effect Of Food Preference On The Efficacy Of The High-Probability Instructional Sequence To Treat Food Selectivity, Christina Marie Sheppard

Theses and Dissertations

Food selectivity involves avoiding certain foods based on type, texture, brand, smell, temperature, or presentation, and it affects 80% of children with intellectual and developmental disabilities. Although several antecedent-based and consequence-based behavioral interventions exist to increase acceptance and consumption of food in this population, one antecedent-based intervention that has shown promise both within and outside of a feeding context is the high-probability instructional sequence, which consists of the delivery of three high-probability instructions before delivery of a low-probability instruction. The high-probability sequence is used to increase compliance with instructions that have a low probability of completion (e.g., taking a bite …

Manganese-Induced Precocious Puberty Alters Mammary Epithelial Cell Proliferation In Female Rats, Alina M. Hamilton, Vinod K. Srivastava, Jill K. Hiney, William L. Dees, Robert K. Dearth

School of Integrative Biological & Chemical Sciences Faculty Publications

Precocious puberty (PP) is an established breast cancer risk factor. In the normal mammary gland, hormone receptor-positive (HR+) cells rarely proliferate. In breast cancer, proliferating epithelial cells are often HR+. It is not known if PP can modify this population of proliferating HR+ cells. Previously, we established a manganese-induced precocious puberty (MnPP) model to study the effects of PP on mammary gland development in female rats. Here, we characterized the distribution of HR+ proliferating mammary epithelial cells in prepubertal and adult rodents, in association with precocious puberty. Female rats were exposed daily to 10 mg/kg manganese chloride or saline (control) …

Optimizing Low-Level Light Therapy For Skin Rejuvenation: Efficacy Of Wavelengths And Treatment Parameters In Collagen Synthesis And Aging Signs, Alejandra Sataray-Rodriguez, Zoee Castro Ojeda, Alexis Moreno Montes, Kaylahn Jones, Amal Umerani, Luna Sataray Arriaga, Zubin Mehta, Kelly Frasier

Student Publications

Low-level light therapy (LLLT), particularly using light-emitting diode (LED) devices, has been an effective and non-surgical option for skin rejuvenation, treating signs of aging such as wrinkles, collagen loss, and pigmentation. Despite promising clinical outcomes, variability in treatment parameters such as wavelength, power density, fluence, and treatment regimens remains a challenge in optimizing the therapy for optimal results. Recent studies, including a prospective, randomized, placebo-controlled, double-blinded, and split-face clinical trial by Lee et al. (2007), have demonstrated significant improvements in wrinkle reduction and skin elasticity using 830 nm and 633 nm LED wavelengths. These findings highlight the importance of wavelength …

Navigating Eating Disorders Through Counseling, Alyssa M. Pelella

Senior Honors Theses

Many different characteristics are involved in eating disorders, each of which helps show that counseling is important to the recovery process. An eating disorder that goes untreated can lead to a higher degree of symptoms over time, like the use of waist trainers, laxatives, and calorie counting. These factors can cause guilt in an individual and can hinder relationships. Males are often overlooked in eating disorder instances, as is the Napoleon complex. Athletes are typically at a higher risk of developing an eating disorder as they are constantly working out, and many times are focused on a goal to fit …

Antimicrobial Eats: How Food Additives Are Contributing To Obesity Via The Gut Microbiome, Olivia Mankos

Senior Honors Theses

The typical modern diet is brimming with food additives used in food processing. Additives such as antibiotic residues, GMOs, pesticide residues, anti-caking agents, emulsifiers, artificial sweeteners, colorants, flavor enhancers, and preservatives. Most of these additives seem to shift the gut microbiome towards more pro-inflammatory signals. When all these additives are considered as an amalgam, such as with the modern processed diet, the ramifications on the gut microbiome are concerning. Obesity, which is characterized by low-level chronic inflammation, is likely exacerbated by these food additives. Consequently, most of these additives should be avoided or banned for optimal health.

Mechanisms Of Behavioral Change In Hosts Of Toxoplasma Gondii: A Review, Olivia Grimsley

Senior Honors Theses

The parasite Toxoplasma gondii is a highly ubiquitous parasite that latently infects an estimated 33% percent of the global population. Toxoplasmosis is of obvious clinical significance due to the extremely high risks to the unborn who contract it congenitally. Less attention has been given to a more subtle aspect of latent infection, which is the behavioral alterations that are commonly experienced by those who contract the parasite. Infected individuals commonly display a variety of altered behaviors, such as increased aggression and risk-seeking behaviors, depression, higher tendency towards suicide and self-directed violence, a loss of fear response, and a greatly increased …

Comparative Analysis Of Regression And Random Forest Models For Player Performance Prediction In The Mls, Joshua Clement Madeti

Senior Honors Theses

Advanced technology and analytics have transformed the world and have benefited several industries throughout, the sport industry being one of them. Data is constantly generated during sports and requires post-game or post-season analysis which is crucial to team and player success. In this paper, the researcher will focus on the impact of analytics on soccer and soccer players. With over three billion active fans, soccer is the most famous sport in the world yet, when it comes to analytics, it is lagging. The thesis includes a comparative study of multiple linear regression and random forest regression to explore whether these …

Earth As Archive: An Interdisciplinary Approach To Possibility And Understanding, Alissa Petrizzo

Honors College Theses

This thesis takes the reader on a journey through the process of literary analysis to uncover new considerations of our past, present, and future. Living in the climate crisis, we are in dire need of the humanistic presence within solution-making conversations. I introduce scholarly voices from anthropologists, environmental scientists, and novelists before diving into Pitchaya Sudbanthad's novel Bangkok Wakes to Rain. While you hear my voice throughout the journey, I exist more so as a tour guide, helping you along the way to new possibilities of understanding. We dig up and analyze evidence of the Earth as an archive …

Does 9/11 Still Act As A Motivator For Individuals Entering The Criminal Justice And National Security Fields?, Ashleigh Lane

Master's Theses

The terror attacks on September 11, 2001 changed the world in an instant, leaving lasting effects on the United States and the international community. This thesis investigates whether the 9/11 attacks continue to serve as a motivating factor for individuals pursuing careers in the Criminal Justice and National Security fields, despite the passage of more than two decades since the event.

This study utilizes secondary research analysis to examine data from empirical studies conducted between 2006 and 2022, with a particular emphasis on students enrolled in Criminal Justice programs at institutions of higher education. Key variables explored include personal victimization, …

Predicting Perinatal Mood Disorders, Honey Newton

Doctor of Nursing Practice

Perinatal Mood Disorders (PMD) constitute a significant public health concern, impacting the perinatal patient and the family.

Purpose

This project describes the relationship between Adverse Childhood Experiences and Perinatal Mood Disorders including depression and anxiety.

Goals

The goals of this study were to define the perinatal population in a rural Montana clinic and describe the relationship between ACEs and PMDs to identify early intervention opportunities.

Methods

A ten-year retrospective IRB approved study described the relationship between ACE, PHQ9 and OASIS scores to determine the prevalence of PMD and connection to ACE’s in perinatal patients in rural northwest Montana. Calculations were …

Spatiotemporal Changes In The Imperiled And Diverse Mussel Assemblage Of The Spring River In Kansas In Response To Known And Emerging Pollutants, Joshua Holloway

Electronic Theses & Dissertations

Kansas was historically home to 50 species of freshwater mussels, of which 42 remain extant. The Spring River of southeastern Kansas is home to 34 of the remaining 42 mussels, many of which are imperiled. Elevated metal concentrations that resulted from past lead and zinc mining in the Tri-State Mining District historically imperiled Spring River mussels, but this threat has abated over the last 20 years. Ammonia pollution may have replaced the threat of metals, however, with potentially severe consequences for Spring River mussels. Our objectives were to evaluate contemporary mussel assemblage structure, in addition to spatiotemporal trends in the …

Pembrolizumab In Patients With Advanced Miscellaneous Rare Cancers: Results From A Phase 2 Basket Trial, Mirella Nardo, Camila Braganca Xavier, Bettzy Stephen, Jeffrey A How, Justin Moyers, Vivek Subbiah, David S Hong, Aung Naing

Faculty, Staff and Student Publications

Introduction: Rare solid tumors account for one-quarter of cancers among adults in the United States, but few resources have been devoted to their treatment. We evaluated the efficacy of pembrolizumab, a programmed cell death-1 inhibitor, in patients with rare solid tumors.

Methods: We conducted a phase 2 basket trial that included patients with rare, advanced tumors. Patients were enrolled in the study in nine tumor-specific and a 10th cohort of miscellaneous rare histologies. Patients received pembrolizumab 200 mg intravenously every 21 days. The primary endpoint was the non-progression rate at 27 weeks per immune-related Response Evaluation Criteria in Solid Tumors …

Ethical Concerns And Implications Of Expanded Carrier Screening, Emily Andres

Undergraduate Honors Capstone Projects

The rapid evolution in the field of genetics is often met with uncertainty and skepticism. With the advancements in genetic technologies, expanded carrier screening (ECS) has emerged as a powerful tool in reproductive medicine. Traditionally, carrier screening was provided less broadly, often relying on ethnic-based approaches. However, further advancements have deemed this practice no longer equitable or widely accepted. While ECS provides prospective parents with insight into their genetic risk and may prevent severe genetic conditions, it also raises serious ethical questions for many. These concerns span medical, political, and societal facets including medicalization, defining severity, abortion, legislation, insurability, the …

The Roles Of Rnt1 And Putative Endoribonucleases In Eukaryotic Mrna Degradation, Lee-Ann Notice-Sarpaning

Dissertations and Theses (Open Access)

Endoribonucleases initiate degradation by cleaving RNAs internally. Mutations in these enzymes have been shown to cause diseases such as cancer, developmental disorders, and neurodegenerative diseases. Yet, eukaryotic endoribonucleases have not been well studied, especially with regard to their role in nuclear mRNA degradation. Rnt1 is a Saccharomyces cerevisiae (budding yeast) nuclear endoribonuclease and homolog of human Drosha with well-characterized roles in the processing of ncRNAs. The enzyme recognizes and cleaves double-stranded RNA stems containing a terminal tetraloop with an AGNN consensus sequence. However, the scope and consequence of its function in mRNA degradation has heretofore been unclear. Previous studies have …