Digital Commons Network^™

Side Effect Profiles In Immunotherapy Vs Chemotherapy In The Treatment Of Pediatric Acute Lymphoblastic Leukemia, Chloe Triolo, Mariana Sales, Amy Nguyen, Jaclyn Schultz, Melissa Crisci

Rowan-Virtua Research Day

Background: Acute lymphoblastic leukemia (ALL) is the most common cancer in children and also one of the most curable, with current cure rates surpassing 90%. Immunotherapy using biologics is an emerging cancer treatment approach that shows significant promise and is generally less toxic than traditional chemotherapy. Due to its lower toxicity compared to chemotherapy, standalone immunotherapy may represent a promising treatment option for pediatric ALL patients.

Hypothesis: This review aims to compare acute side effect profiles and chronic complications in chemotherapy versus immunotherapy treatment modalities for pediatric patients with ALL. Immunotherapy is hypothesized to have a more tolerable side effect …

Accelerated Tumor Growth And Lymphatic Spread Of Transplantable Melanomas In Tumor Necrosis Factor(Tnf)-Transgenic Mice, Catherine F. Alapatt, Robert Hughes, Roger Sheffmaker, Gillian Mcguire, Daniel Deegan, Igor Kuzin, Andrea Bottaro

Rowan-Virtua Research Day

Melanoma is the fifth most common cancer among American adults, with significant morbidity and mortality at 5 years remaining >60% for patients with stage IV disease. The malignancy is due to the transformation of melanocytes, with one of the major risk factors being ultraviolet light exposure. Although as many as one in five human cancers have been linked to chronic inflammation, the role of inflammatory signals in melanoma growth and metastasis remains poorly understood.

Tumor necrosis factor (TNF)-transgenic (TNFtg) mice are a well-established model of chronic systemic inflammation, with involvement of joints and other organ systems. To assess the effect …

Efficacy Of Platelet-Rich Plasma In The Management And Treatment Of Achilles Tendon Ruptures: A Literature Review, Justin Le, Savana Coraggio, Emir Shahin, Valentin Nicholas Kotlyar, Joshua Sassaman, Christopher Cherfane, Gilbert Siu

Rowan-Virtua Research Day

Background

In the world of regenerative medicine, platelet-rich plasma (PRP) has gained much attention as a potential enhancer of musculoskeletal healing. However, despite promising results in many applications, the use of PRP in Achilles tendon ruptures (ATR) remains a topic of debate. While some studies suggest potential benefits in terms of pain reduction and early-phase healing, others report no significant difference in clinical or functional outcomes compared to standard treatment. This inconsistency underscores the need for further investigation into PRP’s role in tendon repair, particularly in high-stress, load-bearing structures such as the Achilles tendon.

Objective

This review aims to evaluate …

From Gut To Heart: Tmao As A Predictive Marker For Cardiovascular Risk, Jasjeet Kaur Dhaliwal, Demi Poulathas

Rowan-Virtua Research Day

Background: Trimethylamine N-oxide (TMAO), a metabolite produced by gut microbiota from dietary nutrients such as choline and carnitine, has emerged as a potential biomarker linking the gut microbiome to cardiovascular disease (CVD). This review synthesizes findings from 31 studies examining the association between circulating TMAO levels and cardiovascular outcomes.

Objective: To evaluate the prognostic value of plasma or serum TMAO concentrations in predicting major adverse cardiovascular events (MACE), including myocardial infarction, stroke, and cardiovascular mortality.

Methods: Studies were identified through a systematic search and screened based on inclusion criteria that required human populations, quantification of blood-based TMAO, and analysis of …

Mechanisms Mediating The Protective Effects Of Caffeine On Alzheimer’S Disease Progression, Jessica Ivanov, Malky Bernat, Joshua Drawbaugh, Jeremy Mehta, Namira Rahmani, Saikumar Thellapally

Rowan-Virtua Research Day

Background: This review aims to examine the molecular mechanisms through which caffeine may exert neuroprotective effects against Alzheimer’s Disease (AD).

Methods: A literature review was done across PubMed and Embase to identify studies between 2000 and 2024, exploring the mechanism behind caffeine’s effects on AD. The criteria focused on peer-reviewed articles involving human or animal models. Information was gathered on study design, participant characteristics, caffeine consumption, proposed mechanisms, and effects on cognition.

Results: The studies support caffeine's potential as a therapeutic, neuromodulator against AD through six mechanisms: inhibition of adenosine A2A receptors, decreased amyloid-beta production and aggregation, promotion of amyloid …

Systematic Review And Meta-Analysis Examining If Hyperplasia Occurs In Humans In Response To Resistance Exercise, Hitesh Gowda, Scott Dankel, Harshal Parmar, Nicholas Barton

Rowan-Virtua Research Day

Background: It is commonly believed that resistance exercise in humans induces muscle growth primarily via muscle hypertrophy, but there is some debate as to whether muscle hyperplasia occurs. The purpose of this meta-analysis was to quantitively assess whether the presence of muscle hyperplasia occurs in humans performing resistance training.

Methods: Medline, Scopus, and Web of Science were searched on May 17, 2024. Studies that assessed muscle fiber number pre and post resistance training were included in a three-level random effects model to assess changes in muscle fiber number.

Results: A total of 11 studies met the search criteria, with all …

The Effect Of Mandatory Enrollment In A Gender Studies Course On Awareness Of Sexism, Gender Attitudes, And Views On Feminism, Sarah Pille

Celebrating Scholarship and Creativity Day (2018-)

The patriarchy is a social construct that allows for the domination, oppression, and exploitation of women. An intervention that can be employed to counteract the outcomes of patriarchal beliefs in college students is gender studies courses. These courses aim to promote awareness of sexism, egalitarian gender attitudes, and positive views of feminism. When enrollment to these courses is made mandatory, it can create resistance to their educational goals. This survey study examined differences in gender and course type on resistance and the educational outcomes of gender studies courses (N = 104). The results of this study indicated that gender studies …

Grains, Seeds & Hay Industry Funding Scheme: 2023-24 Annual Report, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity published reports

The Grains IFS collects funds from producers to address biosecurity pest and disease threats relevant to and determined by the WA grains/seed/hay industry. The current IFS contribution rate of 0.25 cents per tonne of grain and seed, and 0.125 cents per tonne of hay, is applied to the first sale of produce grown in the agricultural areas of WA in 2023-24. Grains IFS contributions fund the:

1. Skeleton Weed Control Program (SKW).

2. Three Horned Bedstraw Eradication Program.

3. Research and Development (R&D) – Research grants and programs to improve the effectiveness and/ or efficiency of the IFS-funded programs, as …

Recollections Of A Tejana Life, Carolina Yáñez

Art Theses and Dissertations

This thesis encompasses the life of a young woman navigating life in Texas through various political and social barriers. My interdisciplinary practice analyzes the historical context of Mexicans in Texas from its Revolutionary period into current injustices. Through fiber, printmaking, and photography I create a visual diary to illustrate what the political has made personal. These works display the beauty of Tejano culture, but also the power struggles that threaten communities I care for, as well as my own existence that persists against far-right wing agendas.

Current politics and government leadership in Texas have inspired me to make artwork calling …

Evaluating Cannabigerol As A Therapeutic Agent In Non-Alcoholic Fatty Liver Disease, Michael J. Viereckl

Master's Theses

Non-Alcoholic Fatty Liver Disease (NAFLD) is a prolific disease worldwide, with rising incidence and limited treatment options. The disease is progressive, what begins as simple lipid congestion within the cells of the liver eventually leads to incitement of inflammatory reactions and destruction of the liver which can further develop into cancer. Epidemiological data suggests that Cannabis use is associated with reduced incidence of NAFLD, and relatively recent changes in the plants legal status now affords us with the opportunity to investigate unstudied cannabinoids in the context of NAFLD. Further, growing popularity of these bioactive compounds as supplements warrants investigation into …

Guidelines For Diagnostic Teleaudiology: Screening, Audiometry, And Speech Audiometry, Elizabeth Hanscome

Doctoral Scholarly Projects & Capstones

By investigating the clinical and technological foundations of teleaudiology, it is possible to capture and relay the capacity to deliver diagnostic audiology services remotely through advancements in telecommunications. A comprehensive analysis of teleaudiology highlights the specialized equipment and knowledge required to conduct these assessments effectively. The need for teleaudiology is ever expanding, granting wider access to care, especially for patients in underserved or rural areas. Teleaudiology has also evolved from its roots in the early 2000s and shows increasing relevance in the field of audiology. The specific technological requirements and protocols necessary for teleaudiology are addressed, with a focus on …

Development Of A Flowchart-Based Algorithm For Alcohol Screening, Brief Intervention, And Referral To Treatment In A Womens’ Healthcare Setting, Caitlin Patricia Vasquez

Doctoral Scholarly Projects & Capstones

Alcohol is the most frequently used and misused substance in the United States and is attributable to more deaths each year than the opioid epidemic. Historically, studies have shown that males are more likely than females to drink alcohol and to drink more heavily than females; however, this gender gap is closing, with emerging research showing women are the fastest growing segment of alcohol consumers in the United States. Compared with men, at-risk alcohol use by women has a disproportionate effect on their health and lives including more rapid progression to alcohol related problems and alcohol use disorders, and harms …

The Conversation Continues: The Judiciary’S Evolving Role In Perpetuating Racial Disparities In Addiction Treatment, Sydney Crute

Fordham Law Review

Language is a powerful means of social control, an idea that resonates deeply with court rhetoric as it relates to race. This Note examines the language courts use when discussing cases related to drug use and addiction. During the crack epidemic, when Black individuals represented the race of the primary drug user and drug dealer, courts relied on racially coded language related to crime and fear. Alternatively, during the opioid epidemic, when White individuals represented the race of the primary drug user, courts relied on more neutral language related to the health and well-being of society. Finally, the language courts …

The Road To Hell Is Paved With Good Intentions: Patents, Pharmaceuticals, And Price Gouging, Madelyn Bird

Northern Illinois Law Review Supplement

Pharmaceutical companies are subject to monopolies of their own making in the pharmaceutical market. Legislators have tried to limit these monopolies by passing legislation in the hopes that it will lower prices. Unfortunately, these attempts to lower the costs of prescriptions have caused more issues to arise over time. When employing complex aspects of intellectual property law, such as evergreening and product hopping, there is no control exerted over pharmaceutical companies.

These monopolies in pharmaceutical markets exist because by the time generic products can enter the market, they have already become outdated. When the generics become outdated, they lose their …

The Fda’S Role In Regulating Access To Gender-Affirming Care Medications, Ryan P. Knox

UC Law Journal

Over the last decade, many states have passed laws seeking to restrict or ban certain medications approved by the United States Food and Drug Administration (FDA). One of the most recent examples: gender-affirming care medications for transgender youth and young adults. As of January 2025, twenty-six states have passed laws banning or restricting the provision of genderaffirming care to minors. Proponents of these laws challenge the procedures and prescription drugs as “experimental,” while critics of these laws characterize both as best-practice medical care. In either case, these laws demonstrate a second-guessing of the FDA’s long-established authority in determining the safety …

Nebline, May 2025

NEBLINE Newsletter Archive from Nebraska Extension in Lancaster County

NEBLINE, May 2025

Tips on Staying Cool During the Heat of a Temper Tantrum

What’s Your BBQ IQ?

May Recipe of the Month — Air Fryer Teriyaki Beef Kabobs

Insect and Disease Control for Organic Vegetable Gardeners

May Garden Guide

Cash Rent Survey

No Matter Where You Live, Submit a Request Before You Dig!

Battling Scales in the Landscape

Three Lancaster County 4-H’ers Modeled Their Sewn Garments at Omaha Fashion Week

Ignite by 4-H 2025 National Conference

May Heart of 4-H Volunteer Award — Dayle Williamson

2024 National Index Study of 4-H Youth

Clover College, June 10–13; Registration Opens in …

Interobserver Variability In Cardiovascular Fdg Pet/Ct Analysis In Large Vessel Vasculitis, Redemptar Kimeu, Anoop Shah, Samuel Gitau, Gemina Doolub, Jeilan Mohamed

Imaging & Diagnostic Radiology, East Africa

Introduction: PET/CT has a synergistic value for optimal diagnosis, disease activity monitoring, and evaluation of damage progression in large vessel vasculitis. The use of standardized uptake values (SUV) as a measurement of relative tissue uptake facilitates comparisons between patients, and has been suggested as a basis for diagnosis. The SUVmean and SUVmax reproducibility in vascular structures is not widely studied.

Objective: The objective of this study was to evaluate the inter-observer variability of both qualitative visual grading of aortic 18F-FDG uptake and the quantitative aortic mean and maximum SUVs in these patients with mild to moderate covid-19 infection …

Implementation Of Residual Tandem Neural Networks For Photonic Inverse Design, Ponthea A. Zahraii

Electrical Engineering and Computer Science (MS) Theses

Deep-learning approaches can greatly benefit the modeling and design of nanophotonic and optical structures. Traditional full-wave simulations are time and resource-intensive, which can act as a bottleneck in photonic design. On the other hand, deep-learning approaches for designing the response of nanophotonic geometries can be computationally inexpensive and produce accurate and efficient results. In this project, we specifically investigate the case of optical forces near meta-structures. We propose using an inverse design approach with residual blocks to account for the deep nature of this architecture and inherently address the non-uniqueness problem. A tandem approach, which consists of two interconnected models, …

The Relationship Between Sense Of Agency And Perceived Stigma In Those With Cognitive Disabilities, Scarlet S. Pardue

Honors Theses

The focus population of this study is those with cognitive disabilities, which limit in some way a person’s ability to complete mental tasks, such as communication, planning, or remembering. The primary purpose is to focus on the participants' sense of agency and perceived stigma. The Sense of Agency Scale (SoA) measures a participant’s consciously perceived control over their mind, body, and the immediate environment. The Perceived Disability Social Stigma Scale (PDSS) measures to what degree participants believe that people with disabilities are stigmatized in their respective communities. Confirmatory research into these two variables offers an interesting insight into how the …

“How Close To The Edge We Are”: Ecologically Reading The Frontiers Of Joan Didion’S Early Nonfiction, Mia R. Speller

Honors Theses

Joan Didion’s work is heavily regional and rooted in place, whether that be the place about which she writes or, by contrast, the place she leaves in order to do her writing. This place-based context takes root in many American ideologies and mythos, like that of the frontier mentality and golden dream. For this reason, exploring Didion’s use of natural metaphor and description as she discusses various cultural phenomena is essential to understanding the layers of her social critiques of 1960’s and 1970’s American culture, especially as they reflect on the failures of the frontier ideology. Further, looking at her …

Nutrition, Sleep, And Training Habits Enhance Endurance Race Performance, Anna F. Breed

Honors Theses

In recent years, marathon and ultra-marathon participation has grown substantially. Past research has shown that a range of variables influence the performance of endurance athletes. This study included participants of the Forgotten Florida 50-mile and 100-mile race and the Chattanooga Erlanger Half-Marathon and Marathon. These athletes were questioned about their sleep, nutrition, and training habits implemented for the races they completed. The results show the significance of carbohydrate consumption throughout the race for energy maintenance and shortened race times. Also, it was found that hill repeats and tempo runs brought about more successful race times for the runners who implemented …

Synthesis Of Single Chain Polymer Nanoparticle Networks By Reinitiating Raft Polymerization, Dallas Donovan

Honors Theses

Hydrogel materials, which are polymer networks comprised mostly of water, hold significant promise for biomedical applications due to their compatibility with biological systems. Conventional hydrogel materials are often brittle and weak, but most applications in biomedical systems require materials to be strong and tough. The topology of a polymer network dictates its mechanical properties. An important strategy for designing tougher hydrogels is the release of stored length, such as from the unfolding of polyprotein cross-linkers. Inspired by the success of the strategy, we report progress towards a fully synthetic design using single chain nanoparticles (SCNPs) into a hydrogel. SCNPs, which …

Sexism In Syntax: Language And Its Relationship With Female Leadership, Kyle Rains

Honors Theses

Despite a global trend towards more equal gender representation, not every country has improved at the same pace or to the same level. This study investigates language as a potential tool for better understanding the differences between countries regarding the presence of female managers. By using language as a tool, I arrive at two primary results: (i) pronoun drop is significantly and inversely associated with the presence of female managers, but gendered language structures have little association, and (ii) a gender intensity index can produce misleading results. These results suggest that language structures, such as pronoun drop, which are associated …

Arthroscopy And The Future Of Surgery: Personal And Public Health Benefits, Preston T. Koski

Honors Thesis

Arthroscopy focuses on operating on the body using probes and working through keyhole incisions on the skin. This rapidly evolving field has seen many innovations in its technology, aided by advances in optical and surgical capabilities. Moreover, it presents many advantages over traditional surgery that directly impact the patient. Shorter recovery time and lessened scarring, reduced postoperative pain and opioid dependence, and less risk of infection are key benefits over open surgery. These benefits can also be applied to areas of public health. Minimizing the burden on hospital resources, reducing the environmental impact of surgery, and improving cost-effectiveness in healthcare …

Perceptions Of Power And Consent: The Role Of Gender, Race, And Sexual Orientation In Assessments Of Victimhood In High School Student-Teacher Relationships, India Campbell

Honors Theses

Sexual abuse, in all of its many forms, has been a controversial topic for centuries. This project looks at a specific subset of sexual abuse: high school student-teacher assaults. Victims of sexual abuse often face barriers to justice. This project addresses several demographic barriers. Research has shown that people of color and members of the queer community are typically reluctant to report due to police and societal perceptions of these groups. Teenagers face additional challenges, such as not know how their peers, parents, school, or community will react. Additionally, their abuser is an authority figure, meaning that these victims could …

Role Of Evolutionarily Conserved G4 Structures In Enhancer-Promotor Interactions, Shahem Alqudah

Honors Theses

Gene regulation is governed by complex networks of interactions between enhancers and promoters, regions of the genome that are typically distant from one another yet functionally linked through chromatin looping. Recent research has revealed the significant role of Gquadruplexes (G4s) in facilitating these interactions. This thesis explores the role of long Gquadruplex regions (LG4s) in enhancer–promoter communication, proposing that these regions mediate physical interactions between enhancers and their target promoters through direct G4:G4 interactions. Using a chromatin conformation capture (EQuIP-seq), electrophoretic mobility shift assays (EMSA), and luciferase reporter assays, the study demonstrates that LG4s may drive gene expression by promoting …

Antiproliferative Effects Of Salvia On Breast Cancers., Allison C. Portaro

College of Arts & Sciences Senior Theses

Breast cancer is the most common cancer diagnosed in female adults, with 2.3 million new cases worldwide in 2020. Plants have been used in traditional medicine and are a potential source of pharmaceuticals. One example is the large Lamiaceae (mint) family. The Salvia genus, commonly known as the sages, is the largest genus in Lamiaceae with almost 900 known species. Salvia lyrata (lyre-leaved sage) has a history of Native American medicinal use to treat cancers and other ailments resulting in this plant being referred to as ‘cancer weed.’ Extracts were produced from the leaves of S. lyrata, S. lyrata …

The Effects Of Prenatal Cigarette Smoke Exposure On Developmental Milestones, Megan Jacobs

College of Arts & Sciences Senior Theses

In Kentucky, a reported 12.7% of mothers smoke cigarettes during pregnancy. Nicotine readily crosses the placental and blood-brain barriers, with fetal blood concentrations reaching 15% higher than maternal levels. By stimulating and desensitizing nicotinic acetylcholine receptors in the autonomic nervous system, nicotine disrupts uteroplacental blood flow, potentially altering fetal growth and development.

To investigate the effects of prenatal cigarette smoke exposure (CSE) on developmental milestones, C57Bl6 mice were exposed to either cigarette smoke (CSE, n = 30) or filtered room air (Sham, n = 20) for 3 hours daily from two days before mating until the day before birth. Offspring …

The Publics Of Hannah Arendt And Jürgen Habermas, Andrew Heggie

College of Arts & Sciences Senior Theses

Hannah Arendt’s and Jürgen Habermas’s accounts of the public are notable and important cornerstones in contemporary western political philosophy. This thesis will offer characterizations of Arendt’s account of the public realm in The Human Condition, and Habermas’s account of the public sphere in The Structural Transformation of The Public Realm, comparing and contrasting these accounts to each other in order to highlight the uniqueness of each account; as well the possible contemporary political relevance of these accounts.

A Qualitative Study On Recruiting And Retaining Black, Veteran, In-Service Teachers In Rural Tennessee K-12 Public Schools, Paul Andrew Mcmillan

Ed.D. Dissertations

The purpose of this qualitative, interpretive study was to explore the perceptions of Black, veteran, in-service teachers regarding recruitment and retention strategies in rural Tennessee K-12 public schools. This study addressed significant racial disparities in the Tennessee education system, where the percentage of Black teachers was notably lower than the percentage of Black students, particularly in rural schools. Data were collected from 20 Black, veteran, in-service teachers using questionnaires and semi-structured interviews to examine the factors influencing their decisions to seek employment and remain in rural districts. Analysis of the data identified three key themes related to Research Question 1 …