Digital Commons Network^™

Advancing Drug-Drug Interaction Prediction Using Multi-Modal Feature Integration With Graph Neural Networks, Ernest C. Chianumba

Theses, Dissertations and Culminating Projects

Pharmaceutical treatments are essential for managing medical conditions, but drug-drug interactions (DDIs) pose significant risks to patient safety and healthcare outcomes. This research integrates Knowledge Graphs and Graph Neural Networks to predict DDIs by exploring complex drug relationships. We construct a comprehensive knowledge graph using DrugBank data (1,000 drugs, 155,774 interactions) enriched with molecular features from PubChem. Our methodology introduces a novel multi-modal approach by integrating transformer-based embeddings (ChemBERTa, SPECTER, and SBERT) to create 1152-dimensional feature vectors that capture structural, biomedical literature, and semantic properties of drugs. Formulating DDI prediction as a link prediction task, we compare three Graph Neural …

Neuronal Tol-1 Integrates Microbial And Metabolic Cues To Modulate Feeding And Aversion In C. Elegans, Gursimran Singh Gujral

Theses, Dissertations and Culminating Projects

Toll-like receptors (TLRs) are key mediators of innate immunity, but emerging evidence suggests that they also play critical roles in the functioning of the central nervous system. This thesis explores the function of TOL-1, the Caenorhabditis elegans homolog of mammalian TLRs, in sensory neurobiology and behavioral responses to nutritive food. In particular, carbon dioxide and ethanol are commonly encountered in microbial environments and can signal metabolically active food sources or potential pathogens. Using tol-1 loss-of-function mutants, neuronal rescue lines, and a combination of molecular, tissue imaging, and behavioral assays, we demonstrate that TOL-1 functions in chemosensory neurons to regulate feeding …

Neuro-Immune Regulation Of Feeding Behavior And Alcohol Intoxication In Caenorhabditis Elegans, Kamya Kiranbhai Shah

Theses, Dissertations and Culminating Projects

Alcohol use disorder (AUD) and obesity are major public health concerns, contributing to more than 28 million deaths annually. Despite extensive research, the mechanisms underlying excessive alcohol and food consumption remain incompletely understood. Emerging evidence suggests that neuro-immune crosstalk plays a pivotal role in feeding and alcohol-induced behaviors, with inflammation as a key pathological hallmark. Toll-like receptors (TLRs), traditionally recognized for their role in innate immunity, have recently been implicated in modulating neural responses to ethanol. However, the mechanisms of how TLR signaling influences feeding and alcohol-related behaviors remain largely unknown. To address this gap, we leveraged Caenorhabditis elegans (C. …

Are We Safe?: An Explanatory Dissertation Of African American Females' Psychological Safety At Work, Loren Ashley Shelley

Theses, Dissertations and Culminating Projects

This dissertation aimed to explore the relationship between demographic diversity and psychological safety within workplace teams, with an additional focus on African American females. Despite extensive research on psychological safety, there is limited understanding of how demographic diversity influences perception of psychological safety within teams and an even more limited understanding of African American females’ perception of psychological safety within teams. The study sought to address this gap by investigating if team similarities and dissimilarities with regards to demographic differences, marginalized identities (moderation), with an emphasis on African American female identity, and microaggressions (mediation) affected individuals’ perceptions of psychological safety …

Faculty Senate Chronicle May 1, 2025, Heather Loughney

The University of Akron Faculty Senate Chronicle

Minutes for the regular meeting of The University of Akron Faculty Senate on May 1, 2025

Exploring The Role Of The Id2 And Rab11fip3 Pathway In X-Linked Chronic Granulomatous Disease (Xcgd) Through Comparative Gene Expression Analysis, Kaili Coenen

Honors Theses

X-linked chronic granulomatous disease (XCGD) is a debilitating immunodeficiency disorder primarily affecting men. The disease results from mutations in the CYBB gene on the X chromosome, which encodes the GP91^PHOX protein responsible for electron transfer from NADPH to molecular oxygen. Despite the identification of the CYBB mutation, the pathological mechanism underlying the reduction in reactive oxygen species (ROS) generation in XCGD remains unclear. We hypothesized that comparative gene expression analysis, combined with pathway analysis, could identify genes and signaling pathways contributing to reduced reactive oxygen species (ROS) levels in XCGD. In this study, we analyzed gene expression data from four …

Ce 611 Syllabus: Development Over The Lifespan, Anquinetta V. Calhoun

Counselor Education Syllabi

This purpose of this course is to promote students' thinking and learning about human growth adaption, and change throughout the lifespan.

Ce 432 Syllabus: Stress Management, Anquinetta V. Calhoun

Counselor Education Syllabi

This course introduces students to the pharmacology of substance abuse disorders and the dynamics of addiction, including medication-assisted therapy.

Women In The Environmental Movement: An Examination Of Maternalistic Rhetoric And Its Relationship To Modern Environmentalism In The 20th Century, Danielle Howie

History Honors Program

From 1942 to 1953, the Hooker Chemical Company decided that an abandoned canal in Niagara Falls was the perfect place to dump 22,000 tons of toxic chemical waste, a common disposal practice that was largely unregulated by the local government. The company covered the 16 acres of hazardous waste with clay and sold it to the Niagara Falls Board of Education in 1953 for one dollar. With a warning included in the property deed that mentioned the presence of chemical waste, the company was excluded from all future liability.2 In the decades to follow, a suburban community would flower around …

Perceptions Of Ketamine-Assisted Psychotherapy, Haley Bowman

Psychology

This research project tests how educational materials influence individuals’ perceptions of ketamine-assisted psychotherapy (KAP). Previous literature indicates that educational materials shape perceptions of credibility. The hypothesis predicts that education will enhance positive perceptions.

This study recruited participants from Sona Systems and Prolific, with 924 individuals completing the study. The questionnaire gathered demographic information, assessed drug use history, and measured participants’ beliefs about the causes of depression. Participants then evaluated treatment credibility by responding to open-ended questions, the Treatment Adherence/Acceptability Scale (TAAS), the Credibility/Expectancy Questionnaire (CEQ), and the KAP credibility questionnaire.

The results indicate that education does not consistently improve perceptions …

Emotional Intelligence And College-Aged Couples’ Relationship Satisfaction, Leeza Milman

Psychology

This study examined the relationship between emotional intelligence (EI) and romantic relationship satisfaction (RAS) among college-aged individuals. Drawing on established models of EI and prior research linking EI to interpersonal functioning, the study tested three hypotheses: (1) higher EI would be positively associated with greater relationship satisfaction, (2) individuals in female same-sex relationships would report higher satisfaction than those in heterosexual relationships, and (3) EI would mediate the relationship between relationship length and satisfaction. A sample of 72 undergraduate students in romantic relationships completed validated measures of emotional understanding, emotion management, regulation difficulties, and relationship satisfaction. Contrary to expectations, no …

Trapped In The Screen: How Digital Dependency Shapes Our Bodies And Minds, Jessica A. Supreme

Psychology

With each successive generation, time spent on cell phones continues to increase, raising concerns about the long-term effects of digital dependency on both physical and cognitive health. Prior research has linked excessive cellphone use to a range of issues including poor posture, eye strain, disrupted sleep, increased anxiety, reduced attention span, and addiction-like behaviors. These concerns are compounded by sedentary lifestyles, which reduce physical activity and contribute to risks such as cardiovascular disease and obesity. This study surveyed individuals aged 18–30 through an online questionnaire assessing daily cellphone usage, physical activity, and sleep habits. Results revealed that both men and …

Development And Characterization Of Aso-Based Ribonuclease Targeting Chimera For The Degradation Of Cug Rna Repeat Expansion In Myotonic Dystrophy Type, Audrey Coons

Chemistry

Myotonic Dystrophy Type 1 is a multisystemic genetic disorder that primarily affects the muscles in the body leading to such pathologies as myotonia, muscle atrophy, insulin resistance and even neurological deficits. This disorder is caused by a series of CUG repeats in the 3’ untranslated region of the DMPK gene; symptoms appear after around 34 repeats. These repeats form foci when MBNL1 protein that deals with alternative splicing of many events in the body, forms aggregations around these repeats. These foci render the MBNL 1 proteins useless. There is no FDA approved therapeutic, but many RNA targeting therapeutics have been …

Non-Invasive Focused Ultrasound To Reduce Gut Inflammation In Parkinson’S Disease, Amal F. Siddiqui

Biological Sciences

Parkinson's Disease (PD) is a neurodegenerative motor disorder that affects millions of people worldwide, with projections suggesting the number of diagnosed cases could reach 15 million by 2040 (Dorsey et al., 2018). While PD is primarily recognized for its impact on movement, it also frequently causes non-motor symptoms, including gastrointestinal (GI) issues such as constipation, which affects 60-80% of patients. Chronic gut inflammation has been proposed as a key factor exacerbating these symptoms. Despite the prevalence of GI complications in PD, they are often overlooked, and existing treatments for constipation are limited in both efficacy and scope. Vagus Nerve Stimulation …

Stimulus Dependence Of Visually Guided Behavior In Drosophila Melanogaster, Jessica Osarenoma Airhienbuwa

Biological Sciences

Vision is very important for navigating the world around us. The fruit fly, Drosophila melanogaster, is a great model for studying how the brain controls visually guided behavior. This is because they have a small nervous system, good genetic tools, and a complete map of their brain connections. In fruit flies, visual projection neurons (VPNs) send information from the eyes to the central brain, which affects what they see and how they act. This research looks at how certain groups of nerve cells influence fruit flies' behavior based on what visual stimuli. To study the brain circuits behind these behaviors, …

Screening Modified Polycyclic Compounds In Myotonic Dystrophy Type 1 Cell Lines, Maria Villacreses Valarezo

Biological Sciences

Myotonic dystrophy type 1 (DM1) is an autosomal dominant neuromuscular disease with no treatment options and causes progressive muscular atrophy and weakness. DM1 occurs when the DMPK gene contains an abnormal CTG repeat expansion in the 3’ untranslated region. Transcription of the expansion leads to sequestration of RNA binding proteins and downstream splicing dysregulation. This dysregulation ultimately affects many systems in the body leading to the DM1 phenotype. This project consists of two parts, with one of our goals being to test experimental small molecule (MPC-04) in an immortalized patient-derived DM1 cell model. Using RNA sequencing data from patient-derived DM1 …

Genomic Diversity Of Salmonella Enterica Serotype Braenderup In New York State, Nicole Zac Soligno

Biological Sciences

The Gram-negative Salmonella enterica (family Enterobacteriaceae) is a common foodborne pathogen mainly isolated from foods of animal origin. Salmonella can be transmitted to humans, causing diverse symptoms, from self-limiting gastrointestinal diseases to more fatal typhoid fever. The young, elderly, and Individuals with weakened immune systems are especially at risk from salmonellosis. Salmonella is a concern to public health and the food industry throughout the world, and its severity depends largely on its serotype, a classification based on the unique combination of surface antigens. In this study, I aimed to elucidate the population structure and antimicrobial resistance determinants of S. enterica …

Regulation Of The Hypothalamic-Pituitary-Adrenal Axis Through Corticotropin-Releasing Factor Receptor 2 Activation And Androgens Acting On Androgen Receptors In Mice Exposed To Repeat Stress Conditions, David Reilly

Biological Sciences

The hypothalamic-pituitary adrenal (HPA)-axis is the body’s main neuroendocrine mechanism for regulating stress. It has been shown in both animal and human models that anxiety and depression like behavior is more prevalent in females compared to males. Studies have shown evidence that suggests there are sex differences in the HPA-axis that likely contribute to the observed sex difference. It has been shown that anxiety related behavior and HPA-axis responsiveness is correlated with androgens acting on androgen receptors (AR). The role of androgens acting on AR has a more unclear role in stress behavior and HPA-axis regulation when subjected to chronic …

The Role Of Cis-Acting Super-Enhancer Long Noncoding Rnas In Triple Negative Breast Cancer Progression, Sakthi Muthukrishnan

Biological Sciences

Breast cancer encompasses a diverse range of diseases characterized by the uncontrolled proliferation of cells within the mammary gland. This condition results in an accumulation of a large number of genetic mutations within an individual, altering the complex internal signaling system of a cell. Millions of women are affected by breast cancer, which remains a significant threat despite medical advancements. Ductal carcinoma in situ (DCIS) acts as a precursor to invasive ductal carcinoma (IDC), however, not all cases progress to invasive cancer. Triple-negative breast cancer (TNBC) is identified to be one aggressive subtype of IDC, where the cells lack sufficient …

Coaggregation With Actinomyces Naeslundii Reduces Corynebacterium Matruchotii Cell Division Rate And Increases In Cell Length, Sarah M. Kenny

Biological Sciences

Corynebacterium matruchotii is believed to form a scaffold-like structure within the human oral cavity so that other species of bacteria have a place to bind. Many types of bacteria may be found within oral biofilms, commonly referred to as dental plaque. Actinomyces naeslundii are associated with dental caries and they are frequently found in dental plaques. Previous studies in our lab have demonstrated that A. naeslundii has a greater coaggregation rate with C. matruchotii than other Actinomyces species. The purpose of this study is to determine the effect of coaggregation with A. naeslundii on C. matruchotii growth kinetics. In this …

Igg4-Related Autoimmune Pancreatitis In Patients With Prior Occupational Exposure: A Case Report And Review Of Risks Concerning Blue-Collared Workers, Zachary A. Coren, Justin Le, Jason Tran, Nicholas Moscardelli, Krish Patel, Joshua Coren

Rowan-Virtua Research Day

Autoimmune pancreatitis (AIP), a manifestation of IgG4-related disease (IgG4-RD), is a rare, often misdiagnosed condition that can closely mimic pancreatic cancer, particularly in its clinical and radiographic presentation. We report the case of a 76-year-old retired plumber who presented with painless jaundice and was initially suspected to have pancreatic cancer based on imaging findings. Subsequent endoscopic evaluation, biopsy, and markedly elevated serum IgG4 levels led to a diagnosis of type 1 AIP. Treatment with corticosteroids resulted in rapid clinical improvement and reduction in IgG4 levels, confirming the diagnosis.

This case highlights the diagnostic challenges of AIP, especially among blue-collar workers …

Exploring The Role Of Lysine Acetylation During Biofilm Formation In Bacillus Subtilis, Jennifer Nguyen, Briana Ericka Reid, Valerie Carabetta

Rowan-Virtua Research Day

Biofilms are structured communities of bacterial cells encased in a self-produced extracellular matrix, composed of polysaccharides, extracellular DNA, and proteins. Bacteria in a biofilm pose significant challenges in healthcare due to their resistance to disinfectants and tolerance to antibiotics. In some species, histone-like proteins were found to be important structural components of the biofilm. Nε-Lysine acetylation is a widespread post-translational modification (PTM) in bacteria, which can alter a protein’s function. The histone-like protein HBsu in Bacillus subtilis is acetylated at seven sites in vivo. We hypothesized that the acetylation state of HBsu may alter biofilm structure or the genetic programming, …

Volatile Anesthetic Exposure During Organogenesis (Weeks 6-9): Implications For Fetal Brain Development, Cheryce Daniel, Kylon Coombs

Rowan-Virtua Research Day

Organogenesis, particularly during gestational weeks 6 through 9, represent a critical window for fetal brain development. During this period, neurogenesis, neural tube closure and synaptic organization are actively occurring. Disruption of these processes, especially from exogenous agents, can result in lasting developmental consequences.

The U.S Food and Drug Administration has issued warnings regarding the use of anesthetic agents such as isoflurane, sevoflurane, and desflurane. Noting the potential risk of neurotoxic effects on the developing brain. This warning is particularly highlighted when administered drugs are present for long periods of time or during repeated procedures. The goal of this literature review …

Dabigatran Reduced Acute Microgliosis In A Mouse Model With Tbi, Nicholas R. Eltman, Rashmeena Abbasi, Mary C. Kosciuk, Syed Ahmed, Jose L. Pascual, Randel L. Swanson, Nimish K. Acharya

Rowan-Virtua Research Day

Objective:

The study objective was to investigate the acute anti-inflammatory effects of dabigatran in a preclinical mouse controlled cortical impact (CCI) model of severe traumatic brain injury (TBI).

Design

Mice were separated into three groups: controlled cortical impact (CCI) with dabigatran (drug treatment, n=5), CCI with saline (positive control, n=5), and sham CCI without saline or dabigatran (negative control, n=3). Dabigatran (80mg/kg) or saline was administered orally at 2, 10, 18, 26, 34, and 42 hours following experimental CCI in the drug treatment or positive control groups, respectively. Animals in the negative control group received sham CCI only. 48h following …

Exploring Intracellular Signaling Responses To Ks18, A Potent Mcl-1 Inhibitor, In Multiple Myeloma, Emily Nelson, Omar S Al-Odat, Dhruti A. Brahmbhatt, Tulin Budak-Alpdogan, Subash Jonnalagadda, Manoj Kumar Pandey

Rowan-Virtua Research Day

Multiple myeloma (MM), a cancer of plasma B cells, is a hematological malignancy in which patients inevitably relapse and develop drug resistance. Mcl-1, a member of the anti-apoptotic subgroup of Bcl-2 family proteins, plays a critical role in the progression of multiple myeloma and contributes significantly to drug resistance. Elevated Mcl-1 expression is observed in approximately 52% of MM patients at diagnosis, increasing to 81% at relapse. Given its driving role in disease progression and therapy resistance, Mcl-1 inhibition has emerged as a promising therapeutic target, prompting ongoing research into the development and clinical evaluation of Mcl-1 inhibitors, particularly for …

Assessing The Fate Of Antibiotic Resistance Genes In Wastewater Treatment Processes, Gunter A. Campbell

Civil Engineering Undergraduate Honors Theses

The increasing need for clean water has paved the way for the creation of systems for reusing water, such as wastewater treatment plants (“WWTPs”), to provide potable water. But in recent years, such systems have raised concerns about the distribution of antibiotic resistance genes (“ARGs”). Bacteria are adapting to antibiotics by the evolution of resistance mechanisms, such as high mutation rates and horizontal transfer. The presence of ARGs, particularly tetracycline ("tetA") resistance genes, in wastewater effluents is of concern, as they can survive treatment, spread to bodies of water, and pose a threat to human health. In this study, the …

What's In It For Me? The Benefits Of Breastfeeding For The Mother, Emily H. Mcmennamy

The Eleanor Mann School of Nursing Undergraduate Honors Theses

The purpose of this systematic review was to investigate both the short- and long-term benefits that breastfeeding has on maternal physical and mental health. The PICOT question was: In postpartum mothers, how does breastfeeding compared to formula and mixed feeding affect maternal physical and mental health, including outcomes in cardiovascular health, BMI, bleeding risk, and mental health both short term and long term? For this research, EBSCOhost and the National Library of Medicine databases were searched to find relevant studies and systematic reviews. Terms such as “breastfeeding and maternal health benefits,” “breastfeeding and postpartum health,” and “breastfeeding and weight loss” …

Indirect Cost Cap: Perspectives On Efficiency, Waste, And Equity, Neel B. Patel, Lakshman Segar

Rowan-Virtua Research Day

Background: On February 10, 2025, the NIH enacted a 15% cap on indirect costs, reallocating $4 billion from institutional overhead to direct research within a $35 billion funding framework. The policy follows longstanding concerns about unchecked growth and inefficiencies in indirect cost reimbursements, which rose from 15% in the 1950s to over 70% at some institutions by the 1990s. Notable examples include a $200 million overcharge at Stanford and millions in questionable expenditures identified in federal audits.

Objective: To evaluate the financial, operational, and equity-related impacts of the NIH’s indirect cost cap on U.S. research institutions.

Methods: …

Children Born To Mothers With Inflammatory Bowel Disease: A Review Of Pediatric Outcomes, Simran Gandhi, Kush Patel, Harmann Singh

Rowan-Virtua Research Day

Background: Inflammatory Bowel Disease (IBD), comprising Crohn’s disease and ulcerative colitis, frequently affects women during their reproductive years. While the impact of IBD on pregnancy has been widely studied, less is known about the long-term health outcomes in children born to affected mothers, particularly in the context of in utero exposure to immunosuppressive therapies.

Hypothesis: We hypothesize that children born to mothers with well-managed IBD experience normal growth and development, with minimal risk for immune-related complications, despite potential exposure to biologics and other IBD medications during gestation.

Methods: A literature review was conducted using PubMed and Google Scholar. Search terms …

Understanding Obesity Risk In Intellectual And Developmental Disabilities: Key Diagnoses And Factors, Elizabeth Kolaski, Wendy Aita, Jennifer Lecomte, Andrea Iannuzzelli

Rowan-Virtua Research Day

Background:

Individuals with intellectual and developmental disabilities (IDD) have obesity rates nearly twice those of the general population, leading to higher rates of diabetes, hypertension, sleep apnea, and reduced quality of life.¹ Genetic syndromes such as Prader-Willi syndrome (PWS) and conditions like autism spectrum disorder (ASD) and Down syndrome (DS) feature distinct mechanisms driving weight gain.² The burden of obesity in IDD exacerbates health disparities and strains caregivers and healthcare systems.³ Yet, comparative obesity prevalence and its drivers across specific IDD diagnoses remain poorly characterized.⁴

Hypothesis:

Obesity prevalence and underlying risk factors differ among IDD diagnoses …