Digital Commons Network^™

Effective Integration Of Multi-Omics With Prior Knowledge To Identify Biomarkers Via Explainable Graph Neural Networks., Rohit K Tripathy, Zachary Frohock, Hong Wang, Gregory Cary, Stephen Keegan, Gregory W. Carter, Yi Li

Faculty Research 2025

The rapid growth of multi-omics datasets and the wealth of biological knowledge necessitates the development of effective methods for their integration. Such methods are essential for building predictive models and identifying drug targets based on a limited number of samples. We propose a framework called GNNRAI for the supervised integration of multi-omics data with biological priors represented as knowledge graphs. Our framework leverages graph neural networks (GNNs) to model the correlation structures among features from high-dimensional 'omics data, which reduces the effective dimensions in data and enables us to analyze thousands of genes simultaneously using hundreds of samples. Furthermore, our …

Conquer And Prevail Issue 187 May 8 2025, Wofford College. Office Of Marketing And Communications

Conquer and Prevail Newsletter

No abstract provided.

Application Of Bioactive Materials Primary Cilia As A Novel Delivery Vehicle, Ayan K. Barui, Farideh Amirrad, Vansh Goel, Sharareh Ohadi, Rajasekharreddy Pala, Ashraf M. Mohieldin, Andromeda M. Nauli, Surya M. Nauli

Pharmacy Faculty Articles and Research

Primary cilia are hair-like structured cell organelles functioning as cellular antennae with chemosensory and mechanosensory roles. Dysfunction of cilia results in ciliopathies, including renovascular diseases (polycystic kidneys, hypertension, aneurysm), mental impedances (Alzheimer's disease, Parkinson's disease, dementia), metabolic diseases (obesity, developmental skeleton defects), blindness, and so on. With a diameter of 150 nm, cilia can be cleaved, released and circulated in the body as injury biomarkers. We here assessed the potential use of isolated cilia as a novel delivery vehicle. Cilia were isolated from renal epithelial cells, and a specific-targeting chemotherapeutic was designed on the cilia. The data show a remarkable …

Disability Lectures, Panel Discussion Improve Medical Student Attitudes, Knowledge In Sd, Keely Walker, Eric Kurtz

Scholarship Pathways Program

Despite growing recognition of persons with disabilities (PWDs) as an underserved population, healthcare disparities persist, often exacerbated by provider misconceptions and lack of training. This study evaluated the impact of a two-part educational module consisting of a didactic session and a panel discussion with individuals with disabilities focused on healthcare students’ knowledge and comfort in caring for patients with intellectual and developmental disabilities (IDDs). Conducted at the University of South Dakota, the sessions included pre- and post-surveys assessing attitudes, confidence, and perceived competencies. Results from 35 participants, primarily medical students, showed statistically significant improvements in 11 of 13 measured domains, …

Patterns Of Taxonomic, Functional, And Phylogenetic Diversity, And Ecological Drivers Of Stream Fish Assemblages In East Texas, Anastasia M. Umstott

Electronic Theses and Dissertations

Freshwater ecosystems in East Texas contain a rich freshwater biodiversity, with the Neches and Sabine River basins supporting some of the greatest freshwater fish diversity in the state. Given the heterogeneity of habitats and species diversity, these rivers serve as excellent natural systems for examining the ecological processes shaping biodiversity patterns and species distributions. In 2023-2024, 60 streams in the Neches and Sabine River basins were surveyed across three seasons to investigate the patterns and ecological drivers of taxonomic (TDβ), functional (FDβ), and phylogenetic β-diversity (PDβ) facets of freshwater fish assemblages. Additionally, I created two ecological niche models for a …

Comparative Three-Barcode Phylogenetics And Soil Microbiomes Of Planted And Wild Strawberry Trees., Flannery Mclamb, Armando Vazquez, Natalie Olander, Miguel F. Vasquez, Zuying Feng, Niharika Malhotra, Liisa Bozinovic, Karen Najera Ruiz, Katherine O'Connell, Joseph Stagg, Goran Bozinovic

Center for Life in Extreme Environments Publications

Taxonomic identification of closely related plants can be challenging due to convergent evolution, hybridization, and overlapping geographic distribution. To derive taxonomic relationships among planted and wild plants across a large geographic range, we complemented three standard plastid barcodes , , and with soil and fruit chemistry, soil microbiome, and plant morphology analyses. Soil and plant sampling included planted from manicured sites in Southern California, USA, wild plants from Southern and Northern California, and wild populations from Mediterranean island of Hvar, Croatia. We hypothesized that phenotypic variation within and between sites correlates with plants' genotype and geographic distribution. Similar fruit chemistry …

Associations Of Muscular And Cardiovascular Fitness Variables With Cardiovascular Disease In Older Adult Athlete Populations, Lauren T. Zick

Honors Thesis

This data analysis examined associations between cardiovascular and muscular fitness indicators and the presence of cardiovascular disease (CVD) in older adult athletes. Using cross-sectional data from 1,110 participants aged 50 and older who completed the Sustained Athlete Fitness Exam (SAFE) at state-level Senior Games events, we evaluated both objective performance metrics and self-reported exercise behaviors. Cardiovascular measures included systolic blood pressure (SBP), waist circumference (WC), waist-to-hip ratio (WHR), and body mass index (BMI). Muscular fitness was assessed through grip strength, maximum walking speed, and chair stand time. CVD status was defined as the presence of two or more self-reported cardiovascular …

A Clinical Review Of Suicide Risks In Dermatology, Rahib K. Islam, Victoria T. Tong, Shari R. Lipner

School of Medicine Faculty Publications

Patients with visible skin diseases, including acne, psoriasis, and atopic dermatitis, face heightened risks of psychological distress, depression, and suicidal ideation, often exacerbated by social stigma and reduced quality of life. This review explores the intersection between dermatology and suicide, highlighting the psychosocial impact of visible skin conditions and the controversies surrounding treatment-related risks, including isotretinoin and biologic exposure. Current evidence suggests that while isotretinoin has been historically linked to mood changes, robust studies do not support a direct association with suicide. Incorporating mental health screenings into dermatological practice is essential for early identification and management of at-risk patients. By …

A Study Of Social And Emotional Learning Provision To Kindergarten Students In A Rural School Through The Lens Of Whole Child Development, Shirley Spiegel

Electronic Theses and Dissertations

The purpose of this Improvement Science Project was to take appraisal of a rural school district’s current approach for developing the whole child in kindergarten. Three prominent context-based child development theories serve as the framework for this study in determining if there is evidence in practice for support of whole child development, or if those practices or components of the current practices do not demonstrate clear evidence for whole child development, according to the theoretical framework. Conducted through the lens of these whole child development theories, this study centered on the Social and Emotional Learning (SEL) provision to kindergarten students …

2025 Undergraduate And Graduate Commencement, Lindenwood University

Commencement Programs

2025 Lindenwood University Commencement program.

Genomic Characterization Of Novel Bacteriophage: Bellis, Emmanauel Z. Gibbs

Honors Theses

Phages are the most abundant life-forms on the planet. Due to their unique ability to infect and lyse specific bacterial strains, phages have been proposed as a potential therapeutic agent to fight antibiotic resistance bacterial infections. Consequently, more research is required to further our understanding of phages. We were provided with an isolated, novel Mycobacterium bacteriophage: Bellis. Utilizing a bioinformatic approach, we successfully annotated Bellis’ genome using a variety of computer programs like GeneMark, Glimmer, HHpred, and PECAAN. We discovered that Bellis has 122 genes, including a RecB-like endonuclease and an AAA-ATPase, as well as 10 tRNAs. Through the genomic …

Genome Annotation Of Stargaze, Madison R. Murray

Honors Theses

Bacteriophages are viruses which solely infect bacteria. They are one of the most abundant and diverse biological entities, yet there is a limited amount of information on these viruses, including their gene functions. Several previously unknown phages have been discovered including Stargaze, whose bacterial host is Mycobacterium Smegmatis. Characterization of phage genes and their functions deepen our understanding of phages and potentially contribute to the broader biomedical effort associated with phages ability to combat bacterial infections. Stargaze is a G5 subcluster phage and it only has one other related phage in its cluster, that phage is from Madagascar. Using a …

Healthcare Provider Comfort Surrounding Adverse Childhood Events (Aces), Cameo Culcasi

Doctoral Projects

Adverse Childhood Experiences (ACEs) are strongly linked to long-term health outcomes, yet discussions around ACEs in clinical settings remain inconsistent. This study investigates the comfort levels of healthcare providers in addressing ACEs with their patients, identifying barriers and facilitators to such conversations. Using a Quasi-experimental, single group, pretest-post test experimental design, we surveyed a diverse group of physicians, nurse practitioners, and physician assistants working in a primary care setting, providing ACE training, and an opportunity for learning reflection. Preliminary results indicate that while most providers acknowledge the importance of discussing ACEs, many report discomfort due to time constraints, lack of …

Executive Watch: Zick On Executive Orders And Official Orthodoxies, Timothy Zick

Popular Media

During his first term as president, Donald Trump signaled that he was not committed to pluralism and expressive liberty when it came to matters like patriotism, public protest, and other forms of dissent. During his second term, Trump has issued multiple executive orders that attempt to impose official orthodoxies or understandings regarding race, gender, patriotism, and other subjects.

As we have seen, these edicts are not merely symbolic. The executive orders call for agency actions and criminal investigations, and place hundreds of millions of dollars in federal funding at risk. The orders have affected what universities teach, which immigrants can …

Examining The Association Between Genetic Polymorphisms And Osteoporosis Among Post-Menopausal Women: A Systematic Review, Zainab Alhalwachi, Mira Mousa, Salsabeel Juneidi, Gabriela Restrepo-Rodas, Spyridon Karras, Habiba Alsafar, Fatme Al Anouti

All Works

Purpose: Postmenopausal osteoporosis (PMOP) is the most prevalent metabolic bone disease among women, characterized by significant bone density loss and increased fracture risk. With a genetic component, a systematic review was conducted on the association between genetic polymorphisms and PMOP risk. Methods: A comprehensive review of PubMed literature examined genetic polymorphisms linked to PMOP risk. The primary outcome was to identify the most frequently studied genes linked to PMOP. The secondary outcome was to perform a meta-analysis on the top genetic markers to assess their overall association with PMOP risk. Results: Six genes, accounting for 55.08 % of all studies, …

Microplastics In Brachyurans: Comparing Contents Of The Atlantic Ghost Crab, Ocypode Quadrata, And Their Surrounding Sediments, Michael See

Honors Theses

The emergence of microplastics as a threat to physiological and environmental health has led to an increase in studies in recent years that aim to identify and quantify potential risks to marine ecosystems. Ocypode quadrata is a species that is a critical component of coastal ecology, leading this study to collect and analyze specimens regarding microplastics and their presence as a pollutant to the marine environment. Samples were collected from beaches along the Grand Strand of South Carolina. Microplastic density and diversity were recorded from investigating fecal pellets from the captive crab specimens to examine microplastic abundance. In addition to …

California Red Hummingbird Flowers: Color Convergence Across Four Biochemical Categories, Melissa León-Osper, Victor Rossi, Katie Conrad, Josephine Hernandez Mena, Elaine Meslow, Amelia A. Fuller, Eduardo Narbona, Justen B. Whittall

Chemistry and Biochemistry

There are 129 red-flowered species in western North America that fit the hummingbird pollination syndrome. Theory predicts that these flowers should produce a specific red color that is conspicuous to hummingbirds but not to bees. In a few well-studied cases, red flowers can be produced with pelargonidin, cyanidin, or both—sometimes complemented with the addition of yellow carotenoids and sometimes not. Which pigment combinations are most common in California and whether they affect conspicuousness to hummingbirds and bees remain unknown. To determine the taxonomic distribution of the pigments responsible for red hummingbird-pollinated flowers, we quantified the color of 36 red-flowered species …

Institutional Connectedness And Social Support Among College Students: Links To Campus Involvement, Carissa Strum

Honors Theses

Background. College is a pivotal period in the lives of students, and an important aspect of the experience is involvement within the campus. College student wellness is also a growing area of interest in higher education, with increased attention on ways to help students thrive. This study explores which aspects of campus involvement contribute to students’ feelings of connectedness and social support. This study aims to 1) assess the association between campus involvement and social support among college students, 2) assess the association between campus involvement and institutional connectedness among college students, and 3) examine whether the association between campus …

Effects Of Acute Exercise On Cognition: Consideration Of Potential Moderators, Lucy C. Wilson, Elizabeth Carwile, Mara Liston, Elizabeth Gaines, Mckenzie Cotten, Mary Griffin

Honors Theses

The present thesis aims to determine the effects, if any, of six potential moderators on the effects of acute moderate-intensity exercise on cognitive functioning. The modes of exercise undertaken by the participants included treadmill (Experiment 1) and stationary bike (Experiment 2) exercise. Participants in each experiment either exercised or rested for twenty minutes and then participated in either a memory recall task or cognitive functioning (“Stroop”) task. The bouts of either exercise or rest on the stationary bike were followed by a rest period during which the participant would be exposed to either standard air oxygen levels (normoxia) or hypoxic …

A Search For Transcriptional Cofactors Of Gcm/Repo Involved In Determining Glia Cell Fate In Drosophila Melanogaster, Nivedha Kosalram

Honors Theses

In Drosophila melanogaster, the mechanism influencing the differentiation of glia and neurons is directed by a key transcription factor known as glial cells missing (gcm). gcm is a crucial regulator of cell fate decision, functioning as a binary switch to direct glial fate in gcm- positive cells and neuronal fate in gcm-negative cells (Jones, et.al, 1995; Hosoya, et.al, 1995; and Vincent, et.al, 1996). In addition to directing gliogenesis, gcm and its homolog gcm2 facilitate the determination of macrophages and tendon cells, highlighting that gcm acts with supplementary factors to induce various signaling pathways in different contexts (Jones, 2005; Johnson, et …

Economic Development In Cartersville, Ms: A Case Study Of A Non-Profit Organization's Community Development Projects, Mckenzie B. Perkins

Honors Theses

The Mississippi Delta Region has long faced significant economic, educational, and health challenges and a steady population decline since the 1940s. In response, community development projects have emerged as powerful tools to promote health, well-being, and social mobility. This thesis investigates the impact of community development initiatives in Cartersville, MS, focusing on the dental clinic, educational programs, and the economic development center established by a non-profit organization. Through the lens of community development theories, the research explores how community leadership, particularly partnerships between EverHope Ministries and Cartersville leaders, is pivotal in addressing health disparities in historically marginalized populations. By engaging …

Have Modern Total Knee Arthroplasty Implant Improvements Affected Revision Rates? A Registry Review Of Modern Implants And Their Predecessors, Alan D. Lam, John Hobbs, Nihir Parikh, David Pipa, Arjun Saxena, Andrew Star

Student Publications

Introduction

Total knee arthroplasty (TKA) is a common orthopaedic procedure used to alleviate pain and restore mobility in patients with knee pain. Substantial resources are committed to updating and refining new knee implant designs to improve outcomes. The aim of this study was to compare revision rates and failure modes between newer implants and their older counterparts.

Methods

A systematic literature review of national registries was conducted to identify predecessor and successor implant designs from four manufacturers. Individual implant revision data points for each implant design across the registries were compared between generations by manufacturer. Reported revision rates of TKA …

Parental Guidance Suggested: Genetic, Epigenetic, And Environmental Factors Shape Allele-Specific Gene Regulation In Metabolic Traits, Celine Louise St. Pierre

Arts & Sciences Graduate Student Theses and Dissertations

Deciphering the “genotype to phenotype” map is a crucial goal of biology. We will not improve our ability to predict phenotypes from DNA sequences until we better incorporate epigenetic and environmental variation into our models of human health and disease. Genes are typically presumed to express both parental alleles equally, but genetic and epigenetic factors can cause one allele to function differently than the other (e.g. expressed or silenced more). These allele-specific imbalances can alter the final composition of a gene’s transcriptional product and ultimately shape phenotypes. Allele-specific effects have widespread impacts on complex traits, but how environmental signals contribute …

Congress Of Neurological Surgeons Systematic Review And Evidence-Based Guidelines For The Role Of Imaging In Newly Diagnosed Who Grade Ii Diffuse Glioma In Adults: Update, Chaitra Badve, Abraham Nirappel

Faculty Scholarship

Target population: Adult patients with suspected or histologically proven WHO Grade II diffuse glioma. Question 1: In adult patients with suspected or histologically proven WHO Grade II diffuse glioma, do advanced MRI techniques using magnetic resonance spectroscopy, perfusion weighted imaging or diffusion weighted imaging provide superior assessment of tumor grade, margins, progression, treatment-related effects, and prognosis compared to standard neuroimaging? Recommendation: Level II: The use of diffusion imaging and dynamic susceptibility contrast (DSC), dynamic contrast enhancement (DCE) and arterial spin labeling (ASL) sequences are suggested to differentiate WHO Grade II diffuse glioma from higher grade gliomas when this is not …

Disrupting Nrf2-Driven Cancer Biology Through One-Carbon Metabolism Inhibition, Julius Chembo

Arts & Sciences Graduate Student Theses and Dissertations

Cancer remains a leading cause of mortality worldwide, with treatment resistance and recurrence posing major barriers to long-term survival. Despite advancements in targeted therapies, many cancers develop resistance to chemotherapy, radiation, and immunotherapy, significantly limiting their effectiveness. One key driver of therapeutic resistance is nuclear factor erythroid 2-related factor 2 (NFE2L2/NRF2), a transcription factor that regulates antioxidant responses and drug detoxification. While NRF2 protects normal cells from oxidative stress, its aberrant activation in cancer promotes tumor progression, metabolic reprogramming, and resistance to standard treatments. Alarmingly, NRF2 hyperactivation is implicated in some of the most aggressive and refractory malignancies, yet no …

Pan-Cancer Universal Targets For Immunotherapy Resulted From Transposable Elements Activation, Yonghao Liang

Arts & Sciences Graduate Student Theses and Dissertations

Transposable elements (TEs) contribute to nearly half of the human genome yet have been overlooked in genomic medicines due to the stereotypic impression as “junk DNA” and technical challenges. However, studies in the last two decades demonstrated that dysregulation of the epigenome in cancer cells resurrects the cis-regulatory functions of TEs, including the promoter activities. The tumor-specific TE activation events along with the resulting tumor-specific RNA and protein molecules, provide a potential “gold mine” for identifying tumor-specific therapeutic targets for cancer treatments, including immunotherapy. Here, I present a series of works to investigate the potential of providing actionable, pan-cancer, and …

Expanding The Druggable Proteome By Integrating Deep Learning With Molecular Simulations To Predict Cryptic Pockets, Artur Meller

Arts & Sciences Graduate Student Theses and Dissertations

Of the protein structures deposited in the Protein Data Bank, less than half have pockets suitable for the binding of drugs. Even when proteins contain pockets in their ground state structures (e.g., the nucleotide-binding active site in myosin motors), achieving specificity remains a central challenge in drug design as many protein families share common structural motifs. Cryptic pockets are cavities absent in ligand-free experimental structures that form due to protein fluctuations in solution. They provide a means to specifically target proteins currently considered undruggable. While cryptic pockets are alluring drug targets, it remains difficult to predict which proteins will form …

Depalmitoylation Regulates Metabolism And Mitochondrial Function, Sarah Lilly Speck

Arts & Sciences Graduate Student Theses and Dissertations

Tens of millions of Americans suffer from metabolic disorders, predisposing patients to cardiovascular disease, kidney disease, liver disease, infertility, and cancer. Unfortunately, the etiology of many of these diseases remains a mystery, limiting our ability to identify targets for pharmacologic therapies. Due to the relationship between altered lipid dynamics and metabolic dysfunction, we decided to study the effect of the posttranslational lipid modification, S-palmitoylation, on metabolism. S-palmitoylation is the only known reversible lipid modification for proteins, and this depalmitoylation process is catalyzed by acyl-protein thioesterases including APT1 and APT2. We hypothesized that APT deficiency in various tissues would predispose mammals …

Mechanisms Of Mll-Rearranged Infant Leukemogenesis, Jonny Mendoza-Castrejon

Arts & Sciences Graduate Student Theses and Dissertations

Infant leukemias arise as either B cell acute lymphoblastic leukemia (B-ALL) or acute myeloid leukemia (AML) and are primarily driven by MLL/KMT2A-rearrangements (MLLr). Prior work has shown that MLLr transform fetal/neonatal hematopoietic progenitors more efficiently than adult progenitors. However, the genetics and epidemiology of MLLr leukemias present an important paradox. MLLr arise during late gestation under conditions that would seemingly favor leukemic transformation (i.e., fetal/neonatal progenitors have high proliferation rates and self-renewal). Furthermore, MLLr infant leukemias require very few cooperating mutations for transformation. Yet congenital leukemias are 10-fold less common than infant leukemias and >100-fold less common than childhood leukemias …

Developing Organizational Leaders’ Personal Mastery Through Emotional Intelligence Training In The Workplace: An Interpretive Phenomenological Analysis, Billie Bruce Relyea

Walden Dissertations and Doctoral Studies

Mayer and Salovey, seminal researchers of emotional intelligence (EI), indicated that the ability measures of EI are still evolving, and the mental abilities involved in EI remain to be determined. Organizational leaders should understand this intention as the key to developing EI and personal mastery, resting firmly upon attaining accurate self-awareness as a prerequisite for human behavior. The purpose of this interpretive phenomenological analysis was to gain an understanding of the socially constructed realities of the lived experiences of organizational leaders and organizational development specialists who have completed Ennea International’s 5 Lens Development Platform (5LDP). Bandura’s social cognitive theory grounded …