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Commencement, South Georgia (2025), Philadelphia College Of Osteopathic Medicine

Commencements

South Georgia Campus Commencement Program, 2025. Degrees include Doctor of Osteopathic Medicine and Master of Science in Biomedical Sciences.

Commencement Speaker: Joseph A. Giaimo, DO '87.

Dry And Wet Deposition Of Atmospheric Microplastics In Las Vegas, Nevada, Laine Adame

UNLV Theses, Dissertations, Professional Papers, and Capstones

Plastics have been one of the most widely used man-made materials since their inception, and production is expected to grow by five percent every year. Plastic waste has become a growing global environmental issue. Primary MPs are plastics that are created to be intentionally tiny for their specific functional purpose. Secondary microplastics (MPs) are byproducts of plastic waste occurring due to the breakdown of larger plastics resulting in the presence and accumulation of MPs in the environment. MPs are defined as tiny particles of plastic between 5 mm and 1 μm in size. MPs have been found in the deep …

Piloting The Inclusion Of Dollar Stores In The Modified Retail Food Environment Index (Mrfei) In Urban Clark County, Nevada, Tiana T. Tu

UNLV Theses, Dissertations, Professional Papers, and Capstones

Food insecurity is the condition of having limited or uncertain access to adequate food. It contributes to poor diet-related health outcomes which are in turn influenced by the food environment. The Centers for Disease Control and Prevention (CDC) developed the Modified Retail Food Environment Index (mRFEI) to characterize food environments by measuring the proportion of healthy and non-healthy retailers. The CDC mRFEI considers a variety of establishments but fails to include dollar stores, which contribute to the food environment by offering food and, in some cases, fresh produce. This study proposed an “expanded mRFEI” that modified the CDC mRFEI methodology …

The Mindful Officer: Enhancing Officer Mental, Physical, And Social Wellness Through Resilience Training, Tanya Dudinskaya

UNLV Theses, Dissertations, Professional Papers, and Capstones

The issue of mental health among the U.S. population has gained national attention, with numerous wide-scale initiatives aimed at providing resources for the public. However, certain professional populations encounter unique challenges in their occupation and often lack specific support for their mental and physical health needs that stem from long-term exposure to unpredictable stressors. One population facing these issues is law enforcement. Police officers regularly experience chronic stress related to their job demands, as they manage high-pressure situations and exposure to significant trauma, all while being under increased public scrutiny in recent years. Previous research has highlighted the effects of …

The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons Of The Transcriptomic Landscapes Across Mouse Models, Ling Cai, Fangjiang Wu, Qinbo Zhou, Ying Gao, Bo Yao, Ralph J Deberardinis, George K Acquaah-Mensah, Vassilis Aidinis, Jennifer E Beane, Shyam Biswal, Ting Chen, Carla P Concepcion-Crisol, Barbara M Grüner, Deshui Jia, Robert A Jones, Jonathan M Kurie, Min Gyu Lee, Per Lindahl, Yonathan Lissanu, Corina Lorz, David Macpherson, Rosanna Martinelli, Pawel K Mazur, Sarah A Mazzilli, Shinji Mii, Herwig P Moll, Roger A Moorehead, Edward E Morrisey, Sheng Rong Ng, Matthew G Oser, Arun R Pandiri, Charles A Powell, Giorgio Ramadori, Mirentxu Santos, Eric L Snyder, Rocio Sotillo, Kang-Yi Su, Tetsuro Taki, Kekoa Taparra, Phuoc T Tran, Yifeng Xia, J Edward Van Veen, Monte M Winslow, Guanghua Xiao, Charles M Rudin, Trudy G Oliver, Yang Xie, John D Minna

Faculty, Staff and Student Publications

Lung cancer, the leading cause of cancer mortality, exhibits diverse histological subtypes and genetic complexities. Numerous preclinical mouse models have been developed to study lung cancer, but data from these models are disparate, siloed, and difficult to compare in a centralized fashion. In this study, we established the Lung Cancer Autochthonous Model Gene Expression Database (LCAMGDB), an extensive repository of 1,354 samples from 77 transcriptomic datasets covering 974 samples from genetically engineered mouse models (GEMMs), 368 samples from carcinogen-induced models, and 12 samples from a spontaneous model. Meticulous curation and collaboration with data depositors produced a robust and comprehensive database, …

G-Quadruplex Stabilizer Cx-5461 Effectively Combines With Radiotherapy To Target Α-Thalassemia/Mental Retardation X-Linked-Deficient Malignant Glioma, Sharvari Dharmaiah, Prit Benny Malgulwar, William E Johnson, Brandon A Chen, Vladislav Sharin, Benjamin T Whitfield, Christian Alvarez, Vasudev Tadimeti, Ahsan S Farooqi, Jason T Huse

Faculty, Staff and Student Publications

Background: Inactivation of α-thalassemia/mental retardation X-linked (ATRX) represents a defining molecular feature in large subsets of malignant glioma. ATRX deficiency gives rise to abnormal G-quadruplex (G4) DNA secondary structures, enhancing replication stress and genomic instability. Building on earlier work, we evaluated the extent to which pharmacological G4 stabilization selectively enhances DNA damage and cell death in ATRX-deficient preclinical glioma models.

Methods: Using the G4 stabilizer CX-5461, we treated patient-derived glioma stem cells (GSCs) in vitro and GSC flank and intracranial murine xenografts in vivo to evaluate efficacy as both a single agent and in combination with ionizing radiation (IR), the …

Enhancing Motor Function In Individuals With Lower Limb Amputation Through Peerbased Learning Of Balance And Fall Recovery Skills, Zoe Castle, Jer Ja Chuang, Jewel Granados, Danna Shaw

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose: Lower limb amputation (LLA) is a devastating condition that is becoming more prevalent in the United States. We examined the effects of peer-based action observation learning on the brain activation and the eyetracking pattern in individuals with LLA.

Methods: Fourteen individuals with LLA (51.9±12.6 years, 4 females, 9 with transfemoral amputations) were asked to learn a balance task through observing the movements demonstrated by individuals with LLA or persons with intact limbs. Electroencephalogram (EEG) signals, visual attention time, and peak saccade velocity were recorded when participants watched the demonstration videos. Power spectral density (PSD) was used to analyze the …

Quick And Easy Method For The Determination Of Cocaine And Six Metabolites In Postmortem Hair, Samantha C. Mulkeen

Student Theses

Hair testing is increasing in popularity in toxicology because of its long window of detection and ease of collection and sample storage. However, it has its limitations largely due to external contamination of drugs. In particular, cocaine (COC) is a common offender of this as it has several routes of consumption. Analyzing metabolites of COC may be the key to distinguishing between consumption and external contamination. The aim of the present study was to develop a quick, easy, and sensitive method for the detection and quantification of COC, benzoylecgonine (BE), norcocaine (NCOC), cocaethylene (CE), anhydroecgonine methyl ester (AEME), meta-hydroxy-cocaine (m-OH-COC), …

Constructing The Soliton Wave Structure And Stability Analysis To Generalized Calogero–Bogoyavlenskii–Schiff Equation Using Improved Simple Equation Method, Mina Fahim, Hamdy Mohamed Ahmed, Islam Samir Soliman, Mohamed Elsaid, Kamal Hassan Eldib

Basic Science Engineering

In this work, we investigated the (3+1)-dimensional generalized Calogero–Bogoyavlenskii–Schiff equation, which models long wave propagation in shallow water and plays a significant role in fluid mechanics and plasma physics. Using the improved simple equations method, we obtained various solutions, including dark, bright, and singular solitons, and combinations of singular periodic solutions and exponential rational solutions. Additionally, we performed a linear stability analysis to examine the stability properties of these wave solutions. To further illustrate their characteristics during propagation, we provided 3D and contour plots for some opted wave solutions.

Examining Validity And Reliability Evidence For The Multicultural Neuropsychological Scale (Muns) Party Subtest Scores, Madyson Hernandez

Masters Theses, 2020-current

Neuropsychological tests were developed primarily for Westernized, Educated, Industrialized, Rich, and Democratic (WEIRD) populations (Henrich, 2020; Fernández & Abe, 2018). According to the American Academy of Clinical Neuropsychology (AACN) Relevance 2050 Initiative project, approximately sixty percent of Americans will be deemed unsuitable for neuropsychological testing because test norms are primarily based on European Americans who speak English (AACN, 2015). To aid in effective cross-cultural neuropsychological assessment, The Multicultural Neuropsychological Scale (MUNS; Fernández et al., 2018) was developed to be easily translatable to various languages. The MUNS is a 40-minute neuropsychological test battery that examines cognitive abilities such as reading fluency, …

Experimentally Testing A Mechanism Of Urban Adaptation: Are Wild Catbirds Able To Immediately Adjust Their Song In Response To Urban Noise?, Eriberto Osorio

Masters Theses, 2020-current

Anthropogenic noise is loud and low-frequency (low-pitch) sound with frequencies spanning from 1-2.5 kHz in frequency. In noisy urban areas, many birds sing songs with higher minimum frequencies, which can avoid the masking effects of anthropogenic noise. However, the mechanism for an individual to alter spectral aspects of bird song in real time to avoid the masking effect of urban noise is unknown. Immediate flexibility is the ability a bird may use to shifts their song frequency or amplitude in response to noise fluctuations in the environment. Some species that sing higher frequency songs in noisy habitats are not able …

Ubiquitin-Conjugating Enzyme Ube2n Modulates Proteostasis In Immunoproteasome-Positive Acute Myeloid Leukemia, Chiharu Ishikawa, Laura Barreyro, Avery M Sampson, Kathleen M Hueneman, Kwangmin Choi, Sophia Y Philbrook, Issac Choi, Lyndsey C Bolanos, Mark Wunderlich, Andrew G Volk, Stephanie S Watowich, Kenneth D Greis, Daniel T Starczynowski

Faculty, Staff and Student Publications

Altered protein homeostasis through proteasomal degradation of ubiquitinated proteins is a hallmark of many cancers. Ubiquitination, coordinated by E1, E2, and E3 enzymes, involves up to 40 E2-conjugating enzymes in humans to specify substrates and ubiquitin linkages. In a screen for E2 dependencies in acute myeloid leukemia (AML), ubiquitin conjugating enzyme E2 N (UBE2N) emerged as the top candidate. To investigate UBE2N's role in AML, we characterized an enzymatically defective mouse model of UBE2N, revealing UBE2N's requirement in AML without an impact on normal hematopoiesis. Unlike other E2s, which mediate lysine-48 (K48) polyubiquitination and degradation of proteins, UBE2N primarily synthesizes …

Between Thirst And Hunger: Food And Afro- Chinese Entanglements In Monkey Hunting, Chloe Huh Prudente

PALARA: Publication of the Afro-Latin/American Research Association

Cristina García’s third novel, Monkey Hunting (2003), is a sweeping multigenerational family saga that surveys the history of Asian and African diasporas in the Americas and the impact of coerced, racialized labor and migrations. The scrumptious medley of foods in Monkey Hunting portrays its characters’ delight and dissatisfaction in their displacements. Food’s primary function remains as a vital source of nourishment, providing essential sustenance to the body. Food provides pleasure through sensory experiences that delight the palate and evoke emotions and memories associated with home and family. In many religions and spiritual systems, food takes a vital place in rituals …

Maintenance Of Graft Tissue-Resident Foxp3+ Cells Is Necessary For Lung Transplant Tolerance In Mice, Wenjun Li, Yuriko Terada, Yun Zhu Bai, Yuhei Yokoyama, Hailey M. Shepherd, Junedh M. Amrute, Amit I. Bery, Zhiyi Liu, Jason M. Gauthier, Marina Terekhova, Jon H. Ritter, Varun Puri, Ramsey R. Hachem, Maxim N. Artyomov, Kory J. Lavine, Ruben G. Nava, Andrew E. Gelman, Daniel Kreisel, Et Al.

2020-Current year OA Pubs

Mechanisms that mediate allograft tolerance differ between organs. We have previously shown that Foxp3+ T cell-enriched bronchus-associated lymphoid tissue (BALT) is induced in tolerant murine lung allografts and that these Foxp3+ cells suppress alloimmune responses locally and systemically. Here, we demonstrated that Foxp3+ cells that reside in tolerant lung allografts differed phenotypically and transcriptionally from those in the periphery and were clonally expanded. Using a mouse lung retransplant model, we showed that recipient Foxp3+ cells were continuously recruited to the BALT within tolerant allografts. We identified distinguishing features of graft-resident and newly recruited Foxp3+ cells and showed that graft-infiltrating Foxp3+ …

Unlv Admissions: Effect Of The In-Person Interview On The Holistic Admissions Of Minority Applicants Into The University Of Nevada, Las Vegas Doctor Of Physical Therapy Program, Jonathan Madamba, Walker Riley, Isaiah Taylor

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose/Methods: The goal of this study is to analyze the effect of an in-person interview on the admission of minority applicants into the Doctor of Physical Therapy (DPT) program at the University of Nevada, Las Vegas (UNLV). Using data from the 2014-2022 admissions cycles we assessed inter-rater reliability of the interviewer’s, differences in average in-person interview score between racial groups, and compared the difference in pre-interview scores between racial groups.

Results: We found that students identifying as Black scored higher on interviews than their White counterparts. However, a smaller proportion of them matriculated into the program due to the difference …

Pre-Service Teacher Self-Efficacy For Classroom Management And Evidence Based Practices For Managing Classroom And Challenging Behaviors, Mathew Benthin

UNLV Theses, Dissertations, Professional Papers, and Capstones

This study investigated the relationship between pre-service teachers' self-efficacy (TSE) and their knowledge of evidence-based practices. Teacher self-efficacy, defined as the belief in one's ability to achieve specific teaching goals, plays a pivotal role in shaping teaching behaviors and student outcomes. Evidence-based practices, grounded in scientific research, are essential for effective teaching and problem-solving in diverse classroom settings. This study highlighted the importance of the two specific resources of self-efficacy and knowledge of evidence-based practices for managing classrooms and challenging behaviors. By exploring pre-service teacher resources, this study aimed to contribute to the body of literature exploring the challenges facing …

New Teachers’ Mentoring Expectations And Experiences: A Qualitative Multiple Case Study, Preston Maurice Blakely

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this qualitative multiple case study was to explore how the expectations of new teachers, about their mentoring program and their mentoring experiences can be used to improve the structural design and procedures of mentoring programs to better support new teachers. Socio-historical and sociocultural theories were used to guide the study and purposive sampling strategy was used to recruit five participants who were in the first years of teaching. Based on a rich set of data sources which included a pre-interview and a post- interview, the findings revealed that despite the existence of mentoring programs in the participants’ …

The Roles Of Oprf In Pseudomonas Aeruginosa Biofilms, Erin K. Cassin

UNLV Theses, Dissertations, Professional Papers, and Capstones

Many bacteria form multicellular communities known as biofilms. Biofilms contain bacterial cells and a protective extracellular biofilm matrix. This matrix contains exopolysaccharides, extracellular DNA (eDNA), membrane vesicles, and proteins. The matrix proteins are far less characterized than other extracellular biofilm components. In biofilms formed by the model organism Pseudomonas aeruginosa, the protein OprF is abundant in the cellular outer membrane and the extracellular matrix. In my dissertation research, I have presented data supporting the hypothesis that the OprF protein significantly affects P. aeruginosa biofilms. By examining various strain backgrounds and the nutrient-dependent effects of glucose and sodium chloride, I demonstrate …

The Effects Of Blood Flow Restriction And Body Weight Support Treadmill Walking On Electromyographic Activity In Lower Limb Muscles, Cyanea Davies

UNLV Theses, Dissertations, Professional Papers, and Capstones

Blood flow restriction (BFR) is an emerging rehabilitation modality shown to enhance muscle activation and elicit strength gains comparable to high-intensity training at lower loads (Cognetti et al.,2019). Body weight support (BWS) treadmill walking is another modality that has gained popularity due to the effect it has on lowering muscle activation with increasing support levels (Jensen et al.,2016). However, to date no research has looked at electromyographic (EMG) activity utilizing both modalities concurrently. This study investigated if stride frequency (SF) and muscle activity of the rectus femoris (RF), biceps femoris (BF), tibialis anterior (TA) and gastrocnemius (GA) would be influenced …

Bridging The Gap: A Quality Improvement Initiative To Enhance Interoception Resources For Pediatric Oncology Ots, Dana Louise Lomotan Doolittle

UNLV Theses, Dissertations, Professional Papers, and Capstones

Chemotherapy administered to children and youth diagnosed with pediatric cancers may induce side effects such as pain, fatigue, anxiety, and other distressing symptoms that could impact the ability to meet occupational needs and desires in daily functioning. The occupational therapy discipline incorporates mindfulness strategies to target these symptoms for increased body awareness in children with cancer, though interoception’s role within the pediatric oncology population is obscure. Furthermore, there are implicated demands described in the literature for more established pediatric oncology rehabilitation programs to attend to the specific needs of the population and to advocate for occupational therapy’s role in the …

Chronic Exposure To Porphyromonas Gingivalis Disrupts Macrophage Innate Immune Responses, Corey Allen Foulk

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: Porphyromonas gingivalis (Pg) is a pathogenic, “red-complex” bacteria found in higher concentrations in advanced gingivitis and periodontitis. Macrophages are capable of adopting numerous phenotypes depending on the surrounding environment. Classic M1 macrophages are the result of inflammatory signals including IFNγ. This study investigated whether naïve M0 macrophages can transition into classic M1 macrophages following stimulation with traditional agonists after cells have been exposed to formalin killed P. gingivalis.Methods: The THP-1 monocytes were differentiated into naïve macrophages (M0) using PMA treatment. The M0 cells were challenged with formalin killed P. gingivalis for 24 hours. After prolonged exposure to P. gingivalis, …

Patterns In Antibiotic Susceptibility Before And After Covid-19, Jessica Freely

UNLV Theses, Dissertations, Professional Papers, and Capstones

The COVID-19 pandemic led to a surge in antibiotic use, despite the viral nature of the disease. This widespread and often unnecessary use of antibiotics poses a serious threat on global health by accelerating the development of antibiotic resistance. Healthcare professionals utilize strategies, including Antibiotic Stewardship Programs (ASPs) and the use of antibiograms to mitigate the growing threat of antibiotic resistance. Antibiograms are tools used in healthcare settings to summarize and track bacterial susceptibility to various antibiotics. They provide clinicians critical information to guide selection of effective antibiotic treatment and monitor resistance trends overtime. The Centers for Disease Control and …

Acquired Brain Injury Education: Utilizing Unfolding Case Studies To Improve Critical Thinking Skills In Occupational Therapy Students, Katherine Hathaway

UNLV Theses, Dissertations, Professional Papers, and Capstones

Acquired brain injuries (ABI), including traumatic brain injury, stroke, and anoxia, affect millions worldwide, and often result in long-term impairments in daily functioning. Despite the need for specialized, ongoing care, many individuals with ABI lack access to adequate long-term rehabilitation services, and families report substantial caregiver burden due to limited resources and poor care coordination. Occupational therapy plays a critical role in meeting the needs of this population; however, many entry-level practitioners feel underprepared to manage the complex challenges associated with ABI, largely due to limited training and exposure. This capstone project aimed to address this educational gap by implementing …

Oral Prevalence Of Selenomonas Noxia Differs Among Orthodontic Patients Compared To Non-Orthodontic Controls: A Retrospective Biorepository Analysis, Kyle Hodges

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: The introduction of fixed orthodontic brackets in orthodontic therapy has the potential to significantly alter the oral microbial flora. Most orthodontic research has focused on cariogenic pathogens, while some evidence has demonstrated an increase in many known periodontal pathogens. However, little is known about the prevalence of the gram-negative periodontal pathogen, Selenomonas noxia (SN) among these patients.Methods: Using an existing saliva biorepository, n=208 samples from adult and pediatric orthodontic and non-orthodontic patients were identified and screened for the presence of SN using qPCR and validated primers. Results: In the pediatric study sample (n=89) 36% tested positive for the presence …

Identifying Alternatively Spliced Events And Exons Between Blood Cell Types, Jessica Holder

UNLV Theses, Dissertations, Professional Papers, and Capstones

Transcript isoforms arising from alternative splicing events can contribute to the development of a cell’s identity and function and overall protein diversity. Peripheral blood is a useful model to study and evaluate computational methods for alternative splicing detection due to its abundant data across various sequencing protocols. The alternative splicing events across different blood cell types have not been completely identified and detecting alternative splicing through short read sequencing is still a challenging problem. Here, we propose to integrate multiple bulk RNA-seq datasets of purified blood cells using a novel integration method to identify the cell-type specific alternative splicing events …

Climate Change And Hydropower Development Impacts In The Lower Mekong Basin, Nudthawud Homtong

UNLV Theses, Dissertations, Professional Papers, and Capstones

The Mekong River Basin is vital to East and Southeast Asia, supporting over 60 million people and sustaining critical ecological systems. However, the basin faces dual threats from climate change and hydropower development, jeopardizing its ecological balance, hydrological patterns, and resource reliability. This research focuses on the Lower Mekong Basin (LMB), where aggressive hydropower expansion and climate variability have intensified concerns about sustainable water management. The study is divided into three interconnected parts. Part I examines spatial and temporal precipitation patterns in the Chi-Mun Basin (CMB) and Lower Mekong River (LMR) from 1950 to 2008, using linear regression and Mann-Kendall …

Dysregulation Of Vitamin D Receptor And Cyp450 Metabolism Enzymes May Explain Oral Cancer Responsiveness, Dustin Hunsaker

UNLV Theses, Dissertations, Professional Papers, and Capstones

Many health benefits are associated with Vitamin D (VitD), although deficiency is associated with poor health outcomes and increased risk for cancer development. For example, many tissue specific enzymes are involved in VitD metabolism, and mutations or deletions within Vitamin D receptor (VDR) genes are known to increase cancer risk by altering their functions or bioavailability, although less is known about these phenomena in oral cancers. Using well characterized, commercially available oral cell lines (OKF4, HGF-1, SCC4, SCC9, SCC15, SCC25, CAL27), mRNA expression of P450 cytochrome VitD metabolic enzymes and receptor genes by qPCR revealed differential results. One oral cancer …

Performance Optimization-Focused Family Behavior Therapy To Address Verbal And Physical Aggression In An Adolescent Diagnosed With Bipolar I Disorder: A Case Report, Sierra Ann Ramirez Jarvis

UNLV Theses, Dissertations, Professional Papers, and Capstones

Bipolar disorder is a chronic and debilitating condition characterized by fluctuations in mood that significantly interfere with day-to-day functioning. While symptom onset typically occurs in early adulthood, manifestations can occur at an earlier developmental stage. Early intervention has been shown to be effective in decreasing long-term negative outcomes and decreasing symptom severity in serious mental illness (SMI) populations, and as such, early intervention treatment programs may have particular benefits for individuals who are early in the course of bipolar disorder. However, there is little information regarding the effectiveness of these programs. This thesis reports a case of an adolescent client, …

Realizing And Practicing Teaching As A Calling: Narratives From Black Women Teachers In Urban K-12 Public Schools, De'ana Renee Mauldin

UNLV Theses, Dissertations, Professional Papers, and Capstones

Research and scholarship frequently ignore and dismiss the unique experiences and perspectives of Black women teachers. They bring with them a unique angle of vision through various race, gender, cultural, and historical intersections that inform their spirituality-based pedagogy and outlook while providing instruction in urban public schools.The purpose of this qualitative dissertation study is to examine the narratives and amplify the voices of Black women K-12 teachers in urban public schools to address how they realized teaching as a calling. Teaching as a calling is more than simply a job and source of income for these teachers. Understanding of this …

El, A Navigational Assistant Based Upon Echolocation, Arthur Mazer

UNLV Theses, Dissertations, Professional Papers, and Capstones

This thesis investigates the integration of a parametric speaker with a microphone array to enhance the echolocation of objects. A parametric speaker focuses ultrasonic and audible waves in a specified direction. This endows the parametric speaker with the capacity to focus waves across a wide frequency spectrum enabling adaptation of the frequency to environmental considerations.Beam forming allows one to focus a microphone array in a specified direction. The thesis investigates different microphone array configurations for the purpose of enhancing the echolocation ability of an echolocation device. The primary goal of the thesis is the construction and testing of an echolocation …