Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 32971 - 33000 of 818734

Full-Text Articles in Entire DC Network

Does An Adapted Swimming Program Improve Self-Efficacy In Individuals With Intellectual Disability?, Georgia Grace Starr May 2025

Does An Adapted Swimming Program Improve Self-Efficacy In Individuals With Intellectual Disability?, Georgia Grace Starr

Theses and Dissertations

BACKGROUND: Short-term adapted swimming programs may improve self-efficacy in individuals with intellectual disability (ID). PURPOSE: We investigated if self-efficacy was improved from the perspectives of swimmers, their parents, and volunteering staff. METHODS: A 5-day program (60 min∙day-1) focused on swim skill development and independence, with each participant supported by a volunteer without disability. Semi-structured interviews were conducted with 5 swimmers (14–35 years, 4 females), 5 parents (40–70 years, all mothers), and 5 volunteers (17–64 years, 4 females). Analysis, using open, structured, and focused coding, highlighted themes aligning with Bandura’s Self-Efficacy Theory (SET)—previous experience, vicarious experience, social persuasion, and feedback—and Self-determination …


An Exploratory Mixed-Methods Investigation Of Previous Sexual Health Communication Between Lesbian, Gay, Bisexual, Or Queer Young Adults And Their Parents, Haley Elizabeth Solace May 2025

An Exploratory Mixed-Methods Investigation Of Previous Sexual Health Communication Between Lesbian, Gay, Bisexual, Or Queer Young Adults And Their Parents, Haley Elizabeth Solace

Theses and Dissertations

Research suggests parent-child communication about sexual health can promote positive sexual health outcomes (e.g., Estrada-Martinez et al., 2020; Jayne et al., 2021); however, parent-child sexual health conversations are often infrequent and heteronormative (Estes, 2017). Few studies explore sexual health communication between LGBQ youth and their parents. This study explores previous experiences with parent-child sexual health communication between seven LGBQ young adults, aged 18 to 26, and four of their heterosexual mothers, to better understand parent-child sexual health communication and differences between parental-child reflections. Findings suggest LGBQ young adults and parents recall similar experiences, however, perceived discomfort and parental competency differently. …


Effects Of Environmental Stress And Antimicrobials On The Health, Microbiome, And Product Shelf-Life Of Channel And Hybrid Catfish, Guyue Tang May 2025

Effects Of Environmental Stress And Antimicrobials On The Health, Microbiome, And Product Shelf-Life Of Channel And Hybrid Catfish, Guyue Tang

Theses and Dissertations

Two studies investigated various aspects of channel and hybrid catfish production and processing. The first study examined the effects of ammonia stress (15 mg/L vs. 1 mg/L control) on growth performance and fillet quality. While channel catfish demonstrated superior growth, ammonia stress minimally impacted the sensory profiles of both species. Gut microbiota analysis revealed species-specific differences, with Lactococcus lactis dominating hybrid catfish communities. The second study evaluated buffered vinegar treatment (1.5%) on fillet shelf life during refrigerated storage. Vinegar-treated fillets maintained better microbiological quality, with aerobic plate counts remaining below 7 log cfu/g through day 6, while untreated fillets exceeded …


Synthetic Data Augmentation For Retinoblastoma Using Diffusion, Andrew Thompson May 2025

Synthetic Data Augmentation For Retinoblastoma Using Diffusion, Andrew Thompson

Theses and Dissertations

Many AI models rely on large and high quality datasets for optimal training. In certain cases, data can be difficult or expensive to obtain, making training difficult. Rare medical conditions are one of these cases. Datasets for retinoblastoma are severely lacking in quantity. Diffusion has been used to create synthetic data in the industrial, medical, and financial domains. By applying the latest Diffusion methods to retinoblastoma, this work seeks to improve predictive model performance on identifying retinoblastoma.


Estimation Of Soybean Root Traits Using Computer Vision And Deep Learning, Muhammad Usman May 2025

Estimation Of Soybean Root Traits Using Computer Vision And Deep Learning, Muhammad Usman

Theses and Dissertations

Root phenotyping provides insights into root structure, function, and response to environmental stimuli, aiding researchers in improving crop yields, developing new plant varieties, and enhancing plant health. Traditionally, measuring root traits, such as length and area, is manual, time-consuming, and resource intensive. This study introduces a deep learning-based computer vision method for soybean root segmentation and traits estimation using RGB (red, green, blue) images captured under controlled illumination. A separate web-based application was also developed that can extract the root length and area using RGB images. A diverse set of 3,363 soybean root images was collected using an in-house root …


Myxozoan Diversity And Life Cycles In Catfish Production Ponds In Mississippi, Usa, Ethan Woodyard May 2025

Myxozoan Diversity And Life Cycles In Catfish Production Ponds In Mississippi, Usa, Ethan Woodyard

Theses and Dissertations

Catfish aquaculture is a critical industry in the United States and Mississippi in particular. The industry is beset by depredation, rising feed costs, competition with imports, and loss to disease. Chief among these is the myxozoan parasite and causative agent of proliferative gill disease, Henneguya ictaluri. In chapter 2, novel molecular markers for greater resolution in species identification of these parasites are provided, allowing more robust life cycle inference, species-level identifications, and inference of evolutionary relationships through molecular phylogenetic analyses. Chapters 3–5 apply the approaches developed in Chapter 2 to a broad array of taxa beyond catfish-infecting Henneguya spp. These …


Climate Change Impacts On Drinking Water Security: A Comparative Study In Australia’S Remote Central Australia And Torres Strait Islands, Nina Lansbury, Julia Bradford, Sandra J. Creamer, Geoffrey Evans May 2025

Climate Change Impacts On Drinking Water Security: A Comparative Study In Australia’S Remote Central Australia And Torres Strait Islands, Nina Lansbury, Julia Bradford, Sandra J. Creamer, Geoffrey Evans

Journal of the Australian Indigenous HealthInfoNet

Aboriginal and Torres Strait Islander communities are well adapted to the many different environments in which they have lived for thousands of years. However, their environments and communities are highly vulnerable to impacts of anthropogenic climate change, including increasing threats to the security of drinking water supplies. Climate change is intensifying the significant social and economic disadvantage Australia’s Aboriginal and Torres Strait Islander communities face from poverty, poor housing, and poor health including high exposure to infectious and other diseases. Lack of sufficient safe, clean, drinking water could force Aboriginal and Torres Strait Islander people to leave their homelands, adding …


Caring With Courage: A Bone Marrow And Hematopoetic Stem Cell Transplant Caregiver Instructional Class And Support Group, Danica J. Dorlette May 2025

Caring With Courage: A Bone Marrow And Hematopoetic Stem Cell Transplant Caregiver Instructional Class And Support Group, Danica J. Dorlette

General Submissions: Clinical Settings Materials

Informal caregiver preparedness plays a crucial role in successful cellular therapy recovery. An interdisciplinary workshop was implemented between 1/2019 and 5/2024 to educate caregivers on symptom management, infection prevention, safe food handling, discharge planning, home safety, and internal and external supportive services. This quality improvement project aimed to increase confidence in caregiver-related tasks.


From Insights To Action: Implications And A Professional Development Framework For Early College High School Teachers, Angelica Sanchez, Kenyetta Martin, Kelly Brown May 2025

From Insights To Action: Implications And A Professional Development Framework For Early College High School Teachers, Angelica Sanchez, Kenyetta Martin, Kelly Brown

School Leadership Review

The purpose of this phenomenological study was to explore the experiences of Early College High School (ECHS) adjunct instructors teaching dual enrollment college courses in a southern region school district. Through interviews with ten ECHS adjunct instructors, the study examined the factors contributing to their success, their professional development needs, and the challenges they faced in teaching dual enrollment courses. Findings of the study were that ECHS adjunct instructors succeed when they provide strong student support, maintain open communication, demonstrate flexibility, and actively engage students. The study highlighted the need for comprehensive training in learning management systems, curriculum design, and …


You Are Not The Hero: Women’S Role In “Rapunzel”, Amber L. Budd May 2025

You Are Not The Hero: Women’S Role In “Rapunzel”, Amber L. Budd

The Confluence

This paper uses the Feminist literary theory to examine the roles and presentation of characters in the fairy tale “Rapunzel” and how the women reinforce patriarchal ideals by conforming to either angelic or monstrous behaviors.


Adverse Cognitions: The Effects Of Childhood Trauma On Brain Development, Faith Salamone May 2025

Adverse Cognitions: The Effects Of Childhood Trauma On Brain Development, Faith Salamone

The Confluence

The effect of adverse experiences in childhood have been known to create lasting difficulties, even in adulthood. While it can be hard to determine the effects of childhood trauma on the brain, many studies have identified areas that appear to be negatively impacted by these adverse childhood experiences. This paper is a meta-analysis of eight articles that have attempted to investigate the effects of childhood trauma on the developing brain. These articles are specifically investigating the effects of childhood physical and/or sexual abuse. The areas that will be discussed in this paper are the prefrontal cortex, corpus callosum, the limbic …


Novel Rpl30 Variant In Diamond Blackfan Anemia Demonstrates Early Impact On Erythroid Differentiation With Downregulated Gata1-Hsp70, Alexandra Prosser-Dombrowski, Irina Pushel, Jacqelyn Nemechek, Priyanka Kumar, Jay L. Vivian, Jennifer Gerton, John M. Perry May 2025

Novel Rpl30 Variant In Diamond Blackfan Anemia Demonstrates Early Impact On Erythroid Differentiation With Downregulated Gata1-Hsp70, Alexandra Prosser-Dombrowski, Irina Pushel, Jacqelyn Nemechek, Priyanka Kumar, Jay L. Vivian, Jennifer Gerton, John M. Perry

Research Days

Background: Diamond Blackfan anemia (DBA) is an inherited bone marrow failure syndrome caused by ribosomal protein gene mutations leading to apoptosis of erythroid progenitors. We identified a novel heterozygous variant (c.167+769C>T) in the noncoding region of RPL30 in a patient diagnosed with DBA.

Objectives/Goal: We hypothesized that this variant stunts erythroid differentiation at the proerythroblast stage and is pathogenic for DBA.

Methods/Design: We developed an induced pluripotent stem cell (iPSC) model with a wild type (WT) and three CRISPR-Cas9 edited RPL30 mutant clones. iPSCs were differentiated into hematopoietic stem cells, which were assessed by flow cytometry and single cell …


Peritoneal Fluid Cytokine Levels In Patients Undergoing Damage Control Laparotomy Differ By Race, Patrick Lyell Bs, Jenna Dennis Bs, Sophia Trinh Md, Cara Ramos Bs May 2025

Peritoneal Fluid Cytokine Levels In Patients Undergoing Damage Control Laparotomy Differ By Race, Patrick Lyell Bs, Jenna Dennis Bs, Sophia Trinh Md, Cara Ramos Bs

Surgery Research Symposium

No abstract provided.


A Preliminary Study Of The Effect Of Pre-Injury Alcohol Consumption On Wound Healing: Focusing On Adipose-Derived Cell Migration And Wound Closure, Abdul-Razak Masoud Phd, C. Dalton, J. Dennis, J.E. Carter May 2025

A Preliminary Study Of The Effect Of Pre-Injury Alcohol Consumption On Wound Healing: Focusing On Adipose-Derived Cell Migration And Wound Closure, Abdul-Razak Masoud Phd, C. Dalton, J. Dennis, J.E. Carter

Surgery Research Symposium

No abstract provided.


Dermatology Residency Education In Treatment Of Testosterone-Induced Acne Vulgaris And Androgenic Alopecia In Transmasculine Individuals: A Cross-Sectional Survey Of Academic Dermatologists, Thinh Q. Nguyen, Bs, Zachary J.K. Neubauer, Bs, Angela Zaldonis, Md, Sherry X. Yang, Md, Faad May 2025

Dermatology Residency Education In Treatment Of Testosterone-Induced Acne Vulgaris And Androgenic Alopecia In Transmasculine Individuals: A Cross-Sectional Survey Of Academic Dermatologists, Thinh Q. Nguyen, Bs, Zachary J.K. Neubauer, Bs, Angela Zaldonis, Md, Sherry X. Yang, Md, Faad

Health Equity and Quality Improvement (HEQI) Summit

Background and Objective

  • Testosterone-induced acne vulgaris (TiAV) and androgenic alopecia (TiAGA) are common dermatologic effects of gender- affirming hormone therapy (GAHT) in transmasculine or non- binary individuals, with prevalence estimates ranging from 31.1% to 88% for TiAV and up to 63.3% for TiAGA. These conditions can contribute to significant psychological distress and may exacerbate gender dysphoria, underscoring the importance of affirming, evidence-based dermatologic care.
  • Despite increasing access to GAHT and the high prevalence of these conditions, there are no standardized guidelines for the management of TiAV and TiAGA, and data on dermatology trainees’ preparedness to care for this population are …


Improving Recognition And Reporting Of Blood Transfusion Reactions In The Inpatient Setting, Tara Rakiewicz, Douglas Russ, Juliana Guarente, Katy Loos, Mary Harach, Jeffrey Riggio, Elizabeth Teixeira, Adam Binder May 2025

Improving Recognition And Reporting Of Blood Transfusion Reactions In The Inpatient Setting, Tara Rakiewicz, Douglas Russ, Juliana Guarente, Katy Loos, Mary Harach, Jeffrey Riggio, Elizabeth Teixeira, Adam Binder

Health Equity and Quality Improvement (HEQI) Summit

Background

  • Blood product transfusion reactions are associated with a spectrum of signs/ symptoms and can be challenging to identify. Transfusion reactions occur in about 1.1% of transfusions and constitute a significant source of iatrogenic morbidity and mortality.
  • There is a nationwide under-reporting of transfusion reactions to blood transfusion Services.
  • At TJUH, formally reported reactions comprised 0.24% of all blood product transfusions in 2024, similar to the national reporting average of 0.22%.
  • Transfusion associated circulatory overload (TACO), and Transfusion related acute lung injury (TRALI) are two leading causes of mortality of blood transfusion reactions (Figure 1).
  • Under-reporting leads to false data …


Region-Specific Proteomic Changes In The Canine Oviduct During Oocyte Maturation Following Deslorelin-Induced Ovulation, Larindhorn Udomthanaisit, Sittiruk Roytrakul, Wirakan Kallayanathum, Sudchaya Bhanpattanakul, Sawanya Charoenlappanit, Theerawat Tharasanit May 2025

Region-Specific Proteomic Changes In The Canine Oviduct During Oocyte Maturation Following Deslorelin-Induced Ovulation, Larindhorn Udomthanaisit, Sittiruk Roytrakul, Wirakan Kallayanathum, Sudchaya Bhanpattanakul, Sawanya Charoenlappanit, Theerawat Tharasanit

The Thai Journal of Veterinary Medicine

Canine reproductive physiology is unique, with oocytes ovulated at an immature stage and completing meiosis within the oviduct. This study investigated protein expression in oviductal secretions from the ampulla and isthmus during oocyte maturation in dogs. Six anestrous female dogs were induced to eestrus using 4.7 mg deslorelin implants, followed by ovariohysterectomy at various time points. Samples were categorized into four groups (n=3 per group) based on oviductal region, histological confirmation, and oocyte maturation status. Proteomic analysis revealed regionspecific protein expression changes linked to oocyte maturation. In the ampulla, PRRG4, RCSD1, and UNC13C were downregulated, while CFAP54, ACLY, and MCOLN1 …


Deutsche Indianertümelei: Germany’S Fascination With Native Americans, Sophia Scime May 2025

Deutsche Indianertümelei: Germany’S Fascination With Native Americans, Sophia Scime

Articulāte

No abstract provided.


Volume 30 May 2025

Volume 30

Articulāte

No abstract provided.


Echoes Of The Plague: The Black Death And The Evolution Of Religious Music In Medieval Italy, Emily Bost May 2025

Echoes Of The Plague: The Black Death And The Evolution Of Religious Music In Medieval Italy, Emily Bost

Articulāte

No abstract provided.


Neurolink-X: Ai-Powered Adaptive Brain-Spinal Fusion Interface For Total Neural Restoration And Full-Body Integration, George Karelias, George Karelias May 2025

Neurolink-X: Ai-Powered Adaptive Brain-Spinal Fusion Interface For Total Neural Restoration And Full-Body Integration, George Karelias, George Karelias

Defensive Publications Series

NeuroLink-X represents a pioneering leap in the convergence of artificial intelligence and neurobiology. This invention details an implantable brain-spinal interface capable of reestablishing functional motor-sensory connectivity between the cerebral cortex and a non-native spinal system. Originally envisioned for cephalosomatic transplantation, the device has transformative implications in treating paralysis, spinal cord injuries, neurodegenerative conditions, and interfacing with artificial bodies.


Master-Level Counseling Students’ Experiences Of Completing A Group Memoir Project In A Human Development And Counseling Course, Yiying Xiong, Shuxin Cheng, Xuelin Sun May 2025

Master-Level Counseling Students’ Experiences Of Completing A Group Memoir Project In A Human Development And Counseling Course, Yiying Xiong, Shuxin Cheng, Xuelin Sun

Journal of Counselor Preparation and Supervision

This study explored the experience of eight master-level students in completing a group memoir project in a Human Development and Counseling course. The project required students to read a memoir and analyze the character using human development theories with a group of students. Adopting a phenomenological approach, themes were generated to describe the students’ experiences, including making the course more engaging, contextualizing diverse human development experiences, building emotional connections with the characters, developing critical thinking about application of human development theories, enhancing learning experience with teamwork, and balancing the structure and flexibility in the project. Implications for counselor educators were …


Teaching Counselors To Work With Infants And Young Children: Why It Matters, Tricia Woodliff, Rachel Jacoby May 2025

Teaching Counselors To Work With Infants And Young Children: Why It Matters, Tricia Woodliff, Rachel Jacoby

Journal of Counselor Preparation and Supervision

Infant and Early Childhood Mental Health (IECMH) is a culturally informed, relationally focused area of clinical expertise which addresses the social-emotional needs of very young children and their families. At this time, although counselors are often providers of this type of clinical work, very little training exists in counselor education programs. This brief explores the integration of this work into counselor education by describing a seamless integration of the IECMH concepts into already existing course work.


Pcsk-9 Inhibitors Treatment: The Cardiovascular Disparity, Julia Lees, Seana-Pierre Williams, Tahir Razzaq, Michael B. Roberts May 2025

Pcsk-9 Inhibitors Treatment: The Cardiovascular Disparity, Julia Lees, Seana-Pierre Williams, Tahir Razzaq, Michael B. Roberts

The Journal of Integrated Primary Care

Introduction: According to the Center for Disease Control and Prevention (CDC) and American Heart Association (AHA), cardiovascular disease is the leading cause of death in the United States. This phenomenon disproportionally affects the African American population, who have a 31% higher mortality rate than non-Hispanic Caucasian individuals. A retrospective review of PCSK-9 medication use, specifically in a patient population that had minimal representation in the large, landmark clinical trials, can lead to better understanding about the therapeutic potential in cardiovascular disease reduction and patient outcomes attributed to medication use. Education regarding this novel drug class, medication access and patient support, …


A Pilot Study Of A Manualized Cognitive-Behavioral Intervention For Opioid Use Disorder Delivered In A Community-Based Public Health Organization, Michelle R. Lent, Denise Botcheos, Chad Gurdgiel, Hannah R. Callahan, Liam Gilroy May 2025

A Pilot Study Of A Manualized Cognitive-Behavioral Intervention For Opioid Use Disorder Delivered In A Community-Based Public Health Organization, Michelle R. Lent, Denise Botcheos, Chad Gurdgiel, Hannah R. Callahan, Liam Gilroy

The Journal of Integrated Primary Care

This pilot study evaluated a previously untested cognitive-behavioral therapy (CBT) intervention designed specifically to treat opioid use disorder (OUD). Adults (N = 20) taking medication for OUD were recruited from a public health organization providing harm reduction and treatment services to people who use drugs in Philadelphia. Outcomes collected at baseline and 12 weeks included urinalysis-confirmed use of illicit drugs and surveys of mood (Patient Health Questionnaire-9; Generalized Anxiety Disorder-7), recovery capital (Brief Assessment of Recovery Capital-10), and cravings (Brief Substance Craving Scale). Feasibility and acceptability were assessed via retention rates, the Client Satisfaction Questionnaire-8, and the number of …


Targeting The Beiging Of Muscle-Associated Adipose Tissue To Promote Muscle Regeneration, Jacob C. Parson May 2025

Targeting The Beiging Of Muscle-Associated Adipose Tissue To Promote Muscle Regeneration, Jacob C. Parson

WUSM Theses and Dissertations – All Programs

The expansion of intra-muscular adipose tissue (IMAT) between myofibers and epi-muscular adipose tissue (EMAT) outside of the muscle boundary accompanies numerous pathologies including diabetes, muscular dystrophy, and aging. IMAT and EMAT are anatomically juxtaposed to myofibers. Some evidence supports that IMAT and EMAT impede muscle function. This is potentially due to paracrine factors that are secreted by IMAT/EMAT. Different adipose depots can be classified in numerous ways including where they are located anatomically as well as the factors in which they secrete. Unlike classical white fat, adipose depots classified as brown or beige, noted by the marker uncoupling protein-1 (UCP-1) …


Children And Chairs, Artifacts And Reality, Adam J. Macleod May 2025

Children And Chairs, Artifacts And Reality, Adam J. Macleod

Catholic University Law Review

Where do children come from? The source of childhood—either nature or political will—is a matter not merely of chronology but of authority. Whoever makes children gets to define childhood. Legal childhood is one type of legal personhood. Legal personhood matters because legal persons bear legal rights and duties. Rights and duties direct how we act toward each other. Thus, our ideas about how persons come to be, who counts as a person, and how persons are defined in law determine in large part how we act toward persons, both other persons and ourselves.

A legal person is an artifact of …


Heterologous Expression And Application Of A Thermophilic Lytic Polysaccharide Monooxygenase, Le Xie, Longyun Peng, Yun Hu, Hongyan Ren, Haiyan Sun, Fubao Sun May 2025

Heterologous Expression And Application Of A Thermophilic Lytic Polysaccharide Monooxygenase, Le Xie, Longyun Peng, Yun Hu, Hongyan Ren, Haiyan Sun, Fubao Sun

Journal of Food Science and Biotechnology

[Objective ] This study aims to investigate the application of a novel thermophilic lytic polysaccharide monooxygenase (LPMO ) in the efficient cellulase-mediated hydrolysis of lignocellulosic substrates.[Method ] The thermophilic enzyme mgLPMO 10,derived from a compost metagenome,was heterologously expressed in Escherichia coli (E.coli ).Its expression level was improved by modifying the signal peptide of the expression vector and induction conditions (temperature,IPTG concentration,and induction time ).The enzyme was then characterized in terms of the optimal temperature,optimal pH,thermal stability,pH stability,and the effects of metal ions on its enzyme activity.Subsequently,the synergistic hydrolysis efficiency of mgLPMO 10 with two thermophilic endoglucanases (TnCelB and DtCelB ) …


Preparation , Performance , And Application Of A High-Performance Affinity Chromatography Medium Based On Staphylococcus Aureus Protein A, Zihao Guo, Chaoqing Yan, Haifeng Xia May 2025

Preparation , Performance , And Application Of A High-Performance Affinity Chromatography Medium Based On Staphylococcus Aureus Protein A, Zihao Guo, Chaoqing Yan, Haifeng Xia

Journal of Food Science and Biotechnology

[Objective ] Staphylococcus aureus protein A (SPA ) is widely used for the purification of monoclonal antibodies due to its high specificity for immunoglobulin G (IgG).However,the high costs of commercial media have limited the further development of SPA.To address this issue,this paper aims to prepare a high-performance affinity chromatography medium based on SPA as the substitute of introduced affinity chromatography media.[Method ] SPA expressed by the recombinant strain was purified via Ni2+ affinity chromatography and then coupled to the Rigose HF matrix to prepare an self-prepared affinity chromatography medium.[Result ] The self-prepared medium had a static saturated adsorption capacity of …


Phrg-Rapg-Degu Quorum Sensing Regulates Menaquinone- 7 Production In Bacillus Subtilis, Junbao Huang, Xilin Huang, Yu Chen, Xuli Gao, Yani Luo, Wei Tao, Yongyuan Liu, Mingyu Guo, Jing Wu, Yan Liu May 2025

Phrg-Rapg-Degu Quorum Sensing Regulates Menaquinone- 7 Production In Bacillus Subtilis, Junbao Huang, Xilin Huang, Yu Chen, Xuli Gao, Yani Luo, Wei Tao, Yongyuan Liu, Mingyu Guo, Jing Wu, Yan Liu

Journal of Food Science and Biotechnology

[Objective ] The effects of the transcription regulation system on menaquinone- 7 (MK- 7) production in Bacillus subtilis (B.subtilis ) 168 were studied by excavating transcription regulators.[Method ] With the signal molecule PhrG pentapeptide,RapG,and the transcription regulator DegU,a PhrG-RapG-DegU regulatory system was successfully constructed in B.subtilis 168 to fine-tune the expression of key genes,so that the expression of key genes in the MK- 7 synthesis pathway can respond to the changes in cell density.[Result ] The production of MK- 7 in strain BS 06 reached 102.47 mg/L through this system.[Conclusion ] Fine tuning of quorum sensing can effectively improve the …