Nf2 Loss-Of-Function And Hypoxia Drive Radiation Resistance In Grade 2 Meningiomas, Bhuvic Patel, Sangami Pugazenthi, Shree S Pari, Tatenda Mahlokozera, William A Leidig, Hsiang-Chih Lu, Alicia Yang, Kaleigh Roberts, Patrick Desouza, Kyle P Mcgeehan, Diane D Mao, Namita Sinha, Joseph E Ippolito, Sonika Dahiya, Hiroko Yano, Albert H Kim, Et Al.

2020-Current year OA Pubs

BACKGROUND: World Health Organization Grade 2 meningiomas (G2Ms) often recur and resist therapies. Grade 2 meningiomas with histopathological necrosis have been associated with worse local control (LC) after radiation therapy, but the drivers and biomarkers of radiation resistance in G2Ms remain unknown.

METHODS: We performed genetic sequencing and histopathological analysis of 113 G2Ms and investigated the role of genetic and microenvironmental factors on clonogenic survival after ionizing radiation. We performed transcriptional profiling of our in vitro model and 18 human G2M tumors by bulk RNA sequencing as well as 8 G2Ms by single nuclei RNA sequencing.

RESULTS: NF2 loss-of-function (LOF) …

Epidemiology Of Shigella Species And Serotypes In Children: A Retrospective Substudy Of The Mal-Ed Observational Birth Cohort Study, Elizabeth T. Rogawski Mcquade, Jie Liu, Mustafa Mahfuz, Alexandre Havt, Furqan Kabir, Adil Kalam, Fatima Aziz, Sahrish Muneer, Najeeha Talat Iqbal, Zulfiqar Ahmed Bhutta

Department of Paediatrics and Child Health

Background: Shigellosis is a leading cause of diarrhoea in children globally. We aimed to assess the burden of specific Shigella species and Shigella flexneri serotypes, characterise their clinical syndromes and natural immunity, and evaluate their relevance as causes of diarrhoea and linear growth faltering.
Methods: In the MAL-ED birth cohort study, children younger than 17 days were enrolled from Nov 3, 2009, to Feb 29, 2012, in Bangladesh, Brazil, India, Nepal, Pakistan, Peru, Tanzania, and South Africa and were followed up for 2 years. In this retrospective substudy, we retested Shigella quantitative PCR-positive diarrhoeal and non-diarrhoeal stool samples with molecular …

Periodontal Diseases In Africa, Mojisola Olujitan, Patricia O. Ayanbadejo, Kehinde Umeizudike, Afolabi Oyapero, Christopher Okunseri, Azeez Butali

School of Dentistry Faculty Research and Publications

Periodontal diseases, a group of complex conditions marked by an excessive immune response and periodontal tissue destruction, are a global health concern. Since 1990, the incidence of these diseases has doubled, with Western sub-Saharan Africa experiencing the highest burden. Accurate diagnosis and case identification are crucial for understanding the etiology, features of disease, research, treatment and prevention. Modern perspectives on periodontal disease classification are based on commonality among those affected. However, current literature is often plagued by methodological inconsistencies and focused on disease mechanisms in European populations. Health inequalities in low- and middle-income countries (LMICs) are exacerbated by these challenges, …

Evaluating Artificial Intelligence Chatbots For Patient Education In Oral And Maxillofacial Radiology, Dilek Helvacioglu-Yigit, Husniye Demirturk, Kamran Ali, Dania Tamimi, Lisa J. Koenig, Abeer Almashraqi

School of Dentistry Faculty Research and Publications

Objective

This study aimed to compare the quality and readability of the responses generated by 3 publicly available artificial intelligence (AI) chatbots in answering frequently asked questions (FAQs) related to Oral and Maxillofacial Radiology (OMR) to assess their suitability for patient education.

Study Design

Fifteen OMR-related questions were selected from professional patient information websites. These questions were posed to ChatGPT-3.5 by OpenAI, Gemini 1.5 Pro by Google, and Copilot by Microsoft to generate responses. Three board-certified OMR specialists evaluated the responses regarding scientific adequacy, ease of understanding, and overall reader satisfaction. Readability was assessed using the Flesch-Kincaid Grade Level (FKGL) …

Ensuring Integrity In Dental Education: Developing A Novel Ai Model For Consistent And Traceable Image Analysis In Preclinical Endodontic Procedures, Mohamed Ibrahim, Meisam Omidi, Arndt Guentsch, Joseph Gaffney, Jennifer Talley

School of Dentistry Faculty Research and Publications

Aim

Academic integrity is crucial in dental education, especially during practical exams assessing competencies. Traditional oversight may not detect sophisticated academic dishonesty methods like radiograph substitution or tampering. This study aimed to develop and evaluate a novel artificial intelligence (AI) model utilizing a Siamese neural network to detect inconsistencies in radiographic images taken for root canal treatment (RCT) procedures in preclinical endodontic courses, thereby enhancing educational integrity.

Methododology

A Siamese neural network was designed to compare radiographs from different RCT procedures. The model was trained on 3390 radiographs, with data augmentation applied to improve generalizability. The dataset was split into …

The Evolution Of Sprinting Performance: Technological And Regulatory Influences From 1976 To 2024, Dariusz Tadeusz Skalski, Magdalena Prończuk, Kinga Łosińska, Ewelina Lulińska, Joanna Motowidło, Petr Stastny, Adam Maszczyk, Grzegorz Trybek

Baltic Journal of Health and Physical Activity

Background: This study examines the progression of sprinting performance across the 100m, 200m, and 400m events from 1976 to 2024, highlighting the influence of technological advancements and regulatory changes. Over the past decades, sprinting has been significantly shaped by developments in track surfaces, footwear technology, training methodologies, and regulatory frameworks. Understanding these factors is essential for assessing how sprint times have evolved and what future trends might emerge. Materials and methods: Utilizing a comprehensive dataset from international athletics federations, this research applies time series analysis, regression modeling, and variance testing to assess trends, gender disparities, and performance variability. Data sources …

Medical College 25th Anniversary Celebrations 1983-2008

University anniversary celebration materials

No abstract provided.

Returning Into The Deep Forest--A Methodological Practice Around Memory, Asianness, And Speech, Yu Ye

Masters Theses

">">The title of this thesis is borrowed from the Tang dynasty poem Deer Enclosure by Wang Wei: “Empty mountain, no one in sight—only the echo of voices. Returning sunlight slips into the deep forest, shining once more on moss.” I feel like my essay is responding to this kind of sensation: light does not shine head-on, but folds back, glancing sideways through dense branches, illuminating what is often overlooked. In that gesture of return—quiet, angled, persistent. This thesis unfolds in three chapters, each following a distinct path—image (Camera Lucida by Roland Barthes), movement (The Rings of Saturn by …

Swing Landscape, Yingwen Lin

Masters Theses

The text will consist of my self-introduction and short articles. Roughly speaking, the narrative is built upon my background and personal transformation. Geographically, I was born in Shenzhen (largest migrant city in China), lived in Shanghai (China’s largest economic center and a major international financial hub), and now reside on the East Coast of the United States, as a particle moving between different cultures, global commodities, and online media. I engage subjectively in these objective changes, with objects and events shaping who I am. I consider myself an outsider, an observer, an economic enthusiast, and a newspaper reader, participating in …

Breath, Void, Ground, Huichun Yang

Masters Theses

Before the sound, there is breath. Before the explosion, there is a threshold. Before the noise, there is silence.

Inspired by the physicality of balloons, this thesis explores breath as sonic material that carries memory, moves through bodies, and resonates across spaces. The balloon becomes a skin that holds breath: a force inhaling trauma, ritual, and intimacy. When released through mouth and latex, breath conjures alien, untranslatable voices that hiss and hum.

It begins with a balloon and expands with endless breath. The balloon becomes a site where the history, body, and voice disintegrate and reform. The pressure and tension …

Colloidal Quantum Dots: A Path Toward Making Mid-Wave Infrared Sensing A Ubiquitous Technology, Mohammad Mostafa Al Mahfuz

Dissertations

Reducing the size, weight, power consumption, and cost (SWaP-C) of infrared detectors could make infrared sensing more widely accessible. In the critical mid-wavelength infrared (MWIR) spectral range of 3-5 gm, commercially available detectors are limited by the high costs associated with epitaxial growth and hybridization, as well as the need for cryogenic cooling. These factors restrict their use to defense and space applications.

Colloidal quantum dots present a promising material for overcoming these challenges, with wafer-scale monolithic integration and Auger suppression being the key material capabilities to minimize the sensor's SWaP-C. Infrared sensors based on colloidal quantum dots have been …

Childhood Neuroanatomical Markers Of Familial And Nonfamilial Attention-Deficit/Hyperactivity Disorder, Rahman Baboli

Dissertations

Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent neurodevelopmental disorder, characterized by developmentally inappropriate levels of inattention, hyperactivity, and impulsivity. Children with family history of ADHD are at an elevated risk of having ADHD as well as a higher risk of persistent ADHD into adulthood, reflecting a source of etiological heterogeneity in ADHD. This heterogeneity in terms of both biological and environmental risk factors may explain differences in neural correlates, outcomes, cognitive, behavioral as well as developmental trajectories. It is therefore critical to understand the influence of having, or not having positive family risk factors on the neuroanatomical structures of the …

On The Design Of A Framework For Large-Scale Exploratory Graph Analytics, Oliver Andres Alvarado Rodriguez

Dissertations

Large-scale exploratory graph analytics merges data science with high-performance computing to extract critical insights from network-representable data. Data scientists routinely analyze data from the natural, social, and computing sciences by representing it as networks, or graphs, where objects become vertices and their relationships become edges. This representation allows data scientists to add graph analytics to their toolbox. However, designing tools for large-scale exploratory graph analytics is challenging due to the complexities of graph algorithms, such as high communication in distributed systems and large memory demands. These challenges can lead to overly complex software, which limits usability and development to a …

The Role Of Excitatory Neuromodulation In Managing Variability Of Neural System Output, Omar Itani

Dissertations

Neural systems can generate consistent outputs across a population despite substantial variability in the underlying components of individuals. This dissertation aims to identify mechanisms through which neuromodulation influences the relationship between parametric and output variability in neural systems. Through a combination of theoretical analysis, computational modeling, and data-driven approaches, the research addresses how excitatory neuromodulation can shape population-level activity variability and identifies key patterns that govern the production of consistent neural population output despite underlying parameter variability.

The theoretical foundation is established by considering how excitatory neuromodulation affects population variability in simplified neuronal models. Two fundamental patterns of variability reduction …

Modulation Of Cerebellar Cells By Transcranial Ac Stimulation In Anesthetized Rats, Qi Kang

Dissertations

Noninvasive brain stimulation (NIBS) is increasingly utilized in clinical trials for the treatment of neurological disorders. Each NIBS technique offers distinct advantages. Transcranial electrical stimulation (tES) is easy to apply and requires only simple equipment, while transcranial magnetic stimulation (TMS) can penetrate deeper than tES into the brain and it is more focal. Transcranial focused ultrasound stimulation (FUS) is superior to both in terms of penetration and focal stimulation. This study focuses on the modulation of the cerebellum, traditionally believed to be associated with motor coordination but increasingly recognized for its role in cognition and emotion as well. While tES …

An Inquiry Into The Physics Of Mixing And Floc Filtration, Andrew P. Pennock

Dissertations

Flocculation and clarification are two essential processes to deliver safe water at a reasonable cost to consumers. There are two major thrusts to the research presented in this dissertation. The first is to better characterize the physics and mixing parameters used for the design of hydraulic flocculators in the context of drinking water treatment plants. The second major thrust is to investigate floc filtration as a mechanism for the removal of primary particles during floc blanket clarification.

The intensity of mixing in environmental and chemical engineering applications is often characterized by the Camp and Stein velocity gradient. This parameter has …

Fact-Checking As A Multi-Step Process: From Ambiguity Resolution To Claim Validation, Wenbo Wang

Dissertations

The spread of misinformation and disinformation has become a major concern, particularly with the rise of social media as a primary source of information for many people. Fact-checking—the process of verifying claims against credible evidence—has emerged as a critical safeguard against misinformation. Yet, the task is fraught with challenges: claims are often ambiguous, context-dependent, or composed of multiple intertwined assertions, while automated systems struggle to replicate the nuanced reasoning of human experts. This dissertation addresses these challenges by reimagining fact-checking as a multi-step, knowledge-guided process that systematically resolves ambiguity, decomposes complexity, and validates claims through structured reasoning. Additionally, the proposed …

Towards Explainable Ai On Graph Neural Networks: Xaig, Jiaxing Zhang

Dissertations

In the evolving landscape of artificial intelligence (AI), Graph Neural Networks (GNNs) have garnered growing prominence for their adeptness in processing graph-structured data. Despite this, the interpretability of their predictions often remains elusive. The demand for transparency and explainability in complex prediction models has reached unprecedented levels. To address this, post-hoc instance-level explanation techniques have emerged, aiming to unveil the rationale behind GNN predictions. These techniques endeavor to unearth substructures that elucidate the predictive behavior of trained GNNs.

This dissertation embarks on an exploration of Explainable AI (XAI) technologies within the realm of GNNs. Amid the challenges posed by the …

Rapid Riparian Ecosystem Decline In Rocky Mountain National Park, David J. Cooper, E William Schweiger, Jeremy R. Shaw, Cherie J. Westbrook, Kristen Kaczynski, Hanem Abouelezz, Scott M. Esser, Koren Nydick, Isabel De Silva, Rodney Chimner

Michigan Tech Publications

Understanding the drivers of ecosystem collapse is critical for resource management, particularly for protected areas mandated to preserve biodiversity. In Rocky Mountain National Park, Colorado, tall willows (Salix spp.) dominated riparian vegetation, and a beaver-willow state was the natural ecosystem type in the Colorado River headwaters. However, willows comprise a portion of elk diets and are a preferred food for recently introduced moose, and the vegetation structure has changed dramatically since the early 2000s. To assess ecosystem changes, we analyzed time-series data on willow height from 1997 to 2021 inside and outside 3 exclosures built to exclude ungulates, area of …

The Stream Of Life, Yitao Yuan

Masters Theses

The repetitive engagement with technological objects erases the depth of emotion by creating habits that bypass embodied and erotic pleasures and lead to a de-sexualized form of technology fetishism. The stimuli produced by machines that humans engage with are not able to convey the strength of intimacy between humans. Such virtual stimuli as the words and images produced and mediated through modern machines continuously shape conscious perception. This thesis book is split into two sections: a theoretical text and a series of images and explanations about my installation practice and process. They both seek to investigate the intersection of human …

Echoes Of Longing, Mahalexmi Mohan

Masters Theses

Loss lingers like a shadow, a weight no time can lift. Longing becomes a silent scream, echoing within, unanswered. Internal pain festers in the quiet, where unhealed wounds weave themselves into the fabric of being. Each breath is both survival and surrender, a fragile balance between hope and the hollow ache of what was, what will never be, yet could be.

Abstract

My work is deeply influenced by my experiences within a dysfunctional family structure and is explored through the relationship of emotional vulnerability and its effect on self-worth. Layered into the work is a confrontation with the scars, conflict …

Body Choice Of Women-507, Yilin Sun

Masters Theses

This thesis examines the struggle for bodily autonomy through the lens of contemporary art, focusing on 507, a kinetic installation by Yilin (Rebecca) Sun. At the heart of this work lies a powerful meditation on the emotional and political dimensions of reproductive responsibility. In a world where women’s rights over their own bodies are frequently contested, 507 becomes both a vessel of remembrance and a visual act of resistance. It channels the often-silenced experiences of women into a shared space of reflection, mourning, and confrontation.

Rather than offering straightforward answers, 507 presents an enigmatic title and a symbolic language …

Cohabitation At Threshold: Carpenter House Reimagined For Multispecies Living, Zhixiao Yang

Masters Theses

With the rapid growth of the human population, we are encroaching further into wildlife habitats, particularly those surrounding urban environments. This accelerating urbanization leads to biodiversity loss, the degradation of ecological services essential to human health and well-being, and a diminishing connection between city dwellers and the natural world.

Today, urban planners, architects, economists, and other advocates for the future of humanity and the health of the planet are actively questioning how we might build greener, more resilient cities. While much of the focus has been on large-scale interventions — such as the use of sustainable materials, the creation of …

The Sound Of Music: Why Do Humans Find Enrichment In Music While Non-Human Primates Do Not?, Sonetta Im Ty

Honors Projects

Music has been observed as an effective enrichment for captive animals across multiple species. However, studies have shown that it is ineffective for promoting welfare in non-human primates (Suborder Haplorhini). These findings were unexpected, given the evolutionary roots shared between humans and non-human primates. This paper addresses several possibilities for this observation, including differences in ear anatomy, brain structure, and music perception between humans and non-human primates.

Naming People, Making Bodies: Reflections On Tukano Onomastics, Geraldo Andrello

Tipití: Journal of the Society for the Anthropology of Lowland South America

This article discusses the topic of names and naming among Amerindian peoples, in particular among Tukano speakers on the Uaupés River, northwestern Amazon. After reviewing the analytical contrast between endonyms and exonyms (i.e., internal transmission of names taken from ancestors versus the capture of names from extra-human sources), I explore endonymic systems through an examination of differences between the Jê and Tukano, considered to be exemplary cases of this naming regime. The Tukano case, explored in more depth towards the end of the article, provides elements that indicate an articulation between both regimes as well as a complex dynamic between …

Do Myths Ever Die? Social-Cultural Changes And Mythical Transformations In Indigenous Amazonia: A Dialogue With Peter Gow, Aparecida M. N. Vilaça

Tipití: Journal of the Society for the Anthropology of Lowland South America

This is the first Peter Gow Memorial Lecture, given at the University of St Andrews in February 2024. Based on the analysis of different versions of Wari’ myths (Rondônia, Brazil) collected over forty years, the paper has two central objectives. The first is to engage with Peter Gow’s analysis of the mythical transformations resulting from the historical changes experienced by the Piro/Yine Indigenous people of Peru. The second is to discuss Lévi-Strauss’s suggestion that a myth can “die” after successive transformations, exhausting itself, taking the form of romantic tale or legendary tradition.

The Industrial Hemp Supply Chain Solution, Honovi C. Trudell Sir

Sustainable Supply Chain Management

Realistically solving the United Nations Sustainable Development Goals utilizing an Industrial Hemp supply chain with economy to scale to replace petroleum based plastics and permanently offset carbon emissions produced from other continuously produced hazardous waste.

Neuroinflammation In The Ventral Tegmental Area Of Chronically Stressed Rats, Marie M. Hafez

Honors Projects

Chronic stress has been associated with maladaptive behaviors in both human and animal research models, but the underlying mechanisms are unclear. In this research study, we sought to define whether stress induces neural inflammation in the ventral tegmental area, the brain region primarily responsible for regulating reward consumption, learning, memory, and addictive behaviors through moderating dopamine release in other brain areas. To do this, male Sprague-Dawley rats were subjected to a chronic intermittent stress paradigm that included stressors such as wet bedding, delayed feedings, social isolation, strobe lights, and forced swims. Following the chronic stress intervention, brain sections were collected …

Welcome To My Mind Palace: The Power Of Fantastical Thinking, Sadie Levine

Masters Theses

What follows is a record of my efforts to make the magic and horrors of my internal world tangible and shareable. The brain constructs hyper-specific fictional realities from childhood to adulthood, yet the scientific study of the mind often forgoes the subjective and the visual. I offer a complementary exploration of the mind - one that is highly visual and based on my own experiences, yet still contextualized in psychological research. Finding the magic in everyday life, and by extension, retreating into alternate realities, is a conscious choice I make, but I have not always had the option to choose. …

Black Parents’ Use Of Educational Advocates: Disrupting Structural And Systemic Racism In Education, Fredericka R. Butler Phd

Dissertations

Research indicates that educators’ deficit perceptions of Black students and their families factor into Black student overrepresentation in disciplinary and special education referrals and underrepresentation in advanced coursework (Annamma et al., 2014; Ford et al., 2023). This prevalence of implicit bias is documented, as is the significance of Black parent involvement in their children’s education (Latunde & Clark-Louque, 2016). Black parents’ awareness of educator racism encourages distrust of educators and interferes with cultivating effective home-school relationships that encourage successful student outcomes. School districts offer the services of educational advocates to provide support to parents whose children are referred for special …