Digital Commons Network^™

Targeting Eya1 Phosphatase Activity In Mll-Rearranged Leukemia, Lola Badmus

Dissertations

MLL-rearranged (MLL-r) leukemia is an aggressive subset of acute leukemia, accounting for up to 10% of adult and 70% of infant AML and ALL cases. These leukemias are driven by MLL fusion proteins, which recruit epigenetic cofactors to dysregulate gene expression, leading to poor prognosis and resistance to conventional chemotherapy. Previous lab work identified EYA1’s role in leukemogenesis, establishing it as a therapeutic target in MLL-r leukemia. EYA1, is a transcriptional coactivator and protein tyrosine phosphatase (PTP). Originally a gout medication, benzbromarone (BBR), was identified in an NCI Diversity Set screen as an EYA1-specific PTP inhibitor. BBR provides a tool …

Correlations Within And Between Highly Multiplexed Proteomic Assays Of Human Plasma, Mary R Rooney, Jingsha Chen, Christie M Ballantyne, Ron C Hoogeveen, Eric Boerwinkle, Bing Yu, Keenan A Walker, Pascal Schlosser, Elizabeth Selvin, Nilanjan Chatterjee, David Couper, Morgan E Grams, Josef Coresh

Faculty, Staff and Students Publications

Introduction: The number of assays on proteomic platforms has grown rapidly. The leading platforms, SomaScan and Olink, have strengths and limitations. Comparisons of precision on the latest platforms-SomaScan 11k and Olink Explore HT-have not yet been established.

Methods: Among 102 participants in the Atherosclerosis Risk in Communities Study (mean age 74 years, 53% women, 47% Black), we used split plasma samples to measure platform precision. CV and Spearman correlations were calculated for each assay. Cross-platform agreement was assessed for overlapping proteins.

Results: SomaScan 11k demonstrated a median correlation of 0.85 for the 10 778 assays and a median CV of …

Lipoprotein(A) And Heart Failure Among Black And White Participants In Atherosclerosis Risk In Communities Study, Framingham Offspring Study, And Multi-Ethnic Study Of Atherosclerosis: The Pooling Project, Sarah Nomura, Weihua Guan, Yixin Zhang, Geoffrey H Tison, Hiroaki Ikezaki, Margaret R Diffenderfer, Ching-Ti Liu, Ron C Hoogeveen, Christie M Ballantyne, Ernst J Schaefer, Michael Y Tsai

Faculty, Staff and Students Publications

Background: This study investigated Lp(a) (lipoprotein(a)) levels with heart failure (HF) incidence overall and ejection fraction (EF) subtypes among Black and White participants in a pooled analysis of MESA (Multi-Ethnic Study of Atherosclerosis), FOS (Framingham Offspring Study), and ARIC (Atherosclerosis Risk in Communities Study).

Methods: This study was conducted among 16 771 White and Black participants in ARIC (N=10 347), MESA (N=4150), and FOS (N=2274). Baseline was time of Lp(a) measurement (ARIC Visit 4: 1996-1998; MESA Visit 1: 2000-2002; FOS Cycle 6: 1995-1998). HF with reduced EF (HFrEF) was defined as EF < 50% and ≥50% as HF with preserved EF (HFpEF). Cox proportional hazards regression was used to evaluate associations between Lp(a) (log-transformed continuous, dichotomized at ≥30 mg/dL and ≥50 mg/dL, and quartiles) and HF (overall, HFpEF, HFrEF) in the overall population and stratified by race. Analyses were replicated excluding prior history of myocardial infarction.

Results: There were 2759 HF cases (HFpEF N=859; …

Mutant P53 Gain Of Function: Why Many See It, Why Some Do Not, Guillermina Lozano, Carol Prives, Kanaga Sabapathy

Faculty, Staff and Student Publications

Mutations in the TP53 tumor-suppressor gene in human cancer are unique in that 60% to 70% are of the missense variety, resulting in a full-length protein that is often highly expressed in patients' tumors. These missense mutant proteins often exhibit pro-oncogenic activities (referred to as gain of function) in mouse models and human cell lines and correlate with poor cancer prognosis in some cases.

Beyond The Surface: Mapping Dde's Metabolic Footprint On Adolescent Obesity, Zhenjiang Li, Shudi Pan, Brittney O Baumert, Jiawen Carmen Chen, Jesse A Goodrich, Hongxu Wang, Sarah Rock, Justin Ryder, Damaskini Valvi, Todd Jenkins, Stephanie Sisley, Xiangping Lin, Scott M Bartell, Thomas H Inge, Stavra Xanthakos, Brooklynn Mcneil, Anna R Robuck, Catherine E Mullins, Sandrah P Eckel, Rob S Mcconnell, Michele A La Merrill, Douglas I Walker, David V Conti, Lida Chatzi

Faculty, Staff and Students Publications

Background: Bariatric surgery is an intervention for severe obesity, leading to significant weight loss and metabolic improvements. However, the release of lipophilic chemicals accumulated in adipose tissue during weight loss presents a unique clinical challenge and research opportunity. Dichlorodiphenyldichloroethylene (DDE) is a persistent organic pollutant increasingly recognized as obesogen, while the biological mechanisms through which DDE influences body mass index (BMI) and waist circumference remain underexplored.

Objectives: We aimed to identify metabolic signatures mediating the association between DDE exposure and weight loss by plasma and adipose tissue metabolomics.

Methods: We conducted a longitudinal study involving 60 adolescents with severe obesity …

An Isometry Theorem For Persistent Homology Of Circle-Valued Functions, Nathan Broomhead, Mariam Pirashvili

School of Engineering, Computing and Mathematics

This paper explores persistence modules for circle-valued functions, presenting a new extension of the interleaving and bottleneck distances in this setting. We propose a natural generalisation of barcodes in terms of arcs on a geometric model associated to the derived category of quiver representations. The main result is an isometry theorem that establishes an equivalence between the interleaving distance and the bottleneck distance for circle-valued persistence modules.

Restoration Of The Tumor Suppressor Function Of Y220c-Mutant P53 By Rezatapopt, A Small-Molecule Reactivator, Anna M Puzio-Kuter, Lizhong Xu, Mary Kate Mcbrayer, Romyr Dominique, Hongju H Li, Bruce J Fahr, Alyssa M Brown, Amy E Wiebesiek, Brandon M Russo, Chris L Mulligan, Hong Yang, Josh Battaglia, Kimberly A Robell, Dafydd H Thomas, Kuo-Sen Huang, Alexander Solovyov, Benjamin D Greenbaum, Jonathan D Oliner, Thomas W Davis, Melissa L Dumble, Melissa L Johnson, Shunbin Xiong, Peirong Yang, Guillermina Lozano, Marc M Fellous, Binh T Vu, Alison M Schram, Arnold J Levine, Masha V Poyurovsky

Faculty, Staff and Student Publications

Restoration of the tumor suppressor function of tumor-associated p53 mutants, including the Y220C substitution, has posed a significant challenge for therapeutic discovery. In this study, we describe rezatapopt (PC14586), part of a series of compounds designed to reactivate the p53 Y220C mutant. These compounds restore p53 tumor suppressor function by correcting its conformation and enabling it to bind DNA and activate downstream target genes, thus inducing antiproliferative changes in tumor cells. Our findings are supported by biochemical and structural analysis, in vitro and in vivo transcriptomics, and functional data, revealing the recovery of multiple aspects of the wild-type p53 program. …

Comparison Of Open And Laparo-Endoscopic Repair Techniques For Patients With Bilateral Inguinal Hernias, Divyansh Agarwal, Tina Bharani, Nora Fullington, Lauren Ott, Kortney Hodgson, Daelyn Mcclain, Kaela Blake, Michael Reinhorn

Department of Surgery Faculty Papers

INTRODUCTION: For primary bilateral inguinal hernias, international guidelines favor a laparoscopic posterior mesh repair due to relatively lower risk of acute and chronic pain, faster recovery, and favorable biomechanical properties compared to open anterior approaches (Lichtenstein, plug and patch, etc.). However, studies comparing open mesh-based bilateral inguinal hernia repairs to bilateral laparoscopic and robotic mesh-based approaches are limited. The Abdominal Core Health Quality Collaborative (ACHQC) registry includes longitudinal data on bilateral inguinal hernia repairs performed via open as well as laparo-endoscopic approaches. We hypothesize that outcomes for bilateral inguinal hernia repair are similar between open and laparo-endoscopic approaches in the …

Houthi Maritime Terrorism: Severing The Iranian Lifeline, Raul (Pete) Pedrozo

International Law Studies

The Houthis have carried out an unprecedented assault on commercial shipping and foreign warships operating in international waters off the Arabian Peninsula that has changed the face of maritime terrorism. These waters are a strategic corridor that facilitates international trade and the movement of naval forces from Europe and the Americas to the Middle East and Asia via the Suez Canal. As a result of the Houthi attacks, most shipping companies rerouted their vessels around Africa via the Cape of Good Hope, which adds significant costs and adversely affects the global supply chain, increasing inflation, and exacerbating food insecurity in …

A Review Of The Persistent Burden Of Post-Covid Headaches In Children, Hajir Karim Abdul-Husseein

Hilla University College Journal For Medical Science

This review focuses on the problem of the headache occurrence in children after COVID. Studies indicated that headaches and fatigue are common long-term symptoms in school-age children following COVID-19 infection. The prevalence of persistent post-COVID headaches in children varies between 5% and 25.4%, often lasting for at least 3 months. Exploration of potential pathophysiological mechanisms of post-COVID headaches in children includes the trigemino-vascular system, viral-induced inflammation, immune system dysregulation, and compromised cerebral blood flow. Age-related immune responses and the expression of receptors like ACE2 may also play a role in pediatric headache development. The features of post-COVID headaches in children …

Three Dimensional Multiscalar Neurovascular Nephron Connectivity Map Of The Human Kidney Across The Lifespan, Liam Mclaughlin, Bo Zhang, Siddharth Sharma, Amanda L Knoten, Madhurima Kaushal, Jeffrey M Purkerson, Heidie L Huyck, Gloria S Pryhuber, Joseph P Gaut, Sanjay Jain

2020-Current year OA Pubs

The human kidney maintains homeostasis through a complex network of up to a million nephrons, its fundamental tissue units. Using innovative tissue processing and light sheet fluorescence microscopy, we mapped the 3D neurovascular connectivity of nephrons to understand how their structural organization enables coordinated functions like filtration, absorption, and blood pressure regulation. Our analysis revealed developmental changes in glomerular orientation, density, volume, and innervation from birth through aging. We discovered an extensive nerve network connecting different nephron segments and organizing glomeruli into distinct communities. These communities are linked through "mother glomeruli" that serve as control centers, creating a repeating pattern …

Contributor Biographies, Editors Of Suurj

SUURJ: Seattle University Undergraduate Research Journal

No abstract provided.

The Effects Of In-Depth Exposure To The Lived Experience Of Aphasia On Student Learning, Brianne Roos, Gretchen Szabo, Tami Brancamp, Elizabeth Hoover, Chaleece Sandberg, Tom W. Sather

Teaching and Learning in Communication Sciences & Disorders

Although individuals with aphasia are commonly treated by speech-language pathologists, many clinicians entering the field feel under-prepared to work with this population. Undergraduate and graduate students need appropriate training that emphasizes person-centered care mapped onto evidence-based practice, combining high-quality research evidence, clinical expertise, and client preferences. Incorporating lived experience into curricula helps shape students’ knowledge and understanding of aphasia from the perspective of patients and carepartners. Using both quantitative and qualitative methods, this study examined the impact of in-depth exposure to the lived experience of aphasia on students across six US universities. Students read the book Identity Theft: Rediscovering Ourselves …

First Convocation Address By Hh Ghulam Ishaq Khan, President Islamic Republic Of Pakistan

Speeches from convocations, inaugurations, and major events

No abstract provided.

Investigation Of A Polymer-Based Holographic Grating For Visible Light Dosimetry Using A Bleachable Dye, Saoirse Maher, Denise Denning, Jackie Mccavana Dr., Seán Cournane Dr., Suzanne Martin Dr., Dervil Cody

Conference Papers

Holographic sensors are of interest for a range of sensing tasks because of their high sensitivity, rapid response time, broad dynamic range, lightweight characteristics, and design flexibility. The practical application of holography makes it possible to design optical sensors that are effective in the visible and near-infrared ranges. The objective of this research is to construct a holographic grating that is customised to provide quantitative data in visible light dosimetry applications. Upon exposure to visible light, the proposed holographic grating will produce a measurable change in diffraction efficiency based on the bleaching of the grating material. In the evolution of …

A Multiple Case Study On Cisgender Women Experiences In Electrical And Computer Engineering And Computer Science Majors, Alena Marie Degeorge

Theses and Dissertations

Gender disparities are found in Science, Technology, Engineering, and Math (STEM) education because of gender norms and stereotypes that project the ideology that men are better at those subjects than women. Women who pursue a college education in STEM encounter barriers that influence them to switch to a non-STEM-related major making them part of the leaky pipeline. This case study examines the experiences that junior and senior cisgender women have while pursuing an electrical and computer engineering or computer science degree and how they overcome barriers they encounter to continue their educational pursuits in a Computer Science and Engineering (CSE) …

Developing Full Performance Interpreters: Cultivating Interdisciplinary Mindsets And Skillsets To Engage Audiences In Climate Change, Women's History, And Other Contested Heritage Topics, Delia A. Lister

Dissertations

Heritage sites immerse visitors in places where the impacts of climate change are readily apparent. They are also powerful places to elevate untold stories of women and girls. Heritage site interpreters interact daily with audiences who bring diverse lived experiences, different levels of subject matter knowledge, and multiple perspectives on climate change and the role of women in history. Every visitor interaction has a set of meanings, values, and narratives that visitors knowingly or unknowingly espouse. To interpret contested heritage topics, such as climate change and women’s history, interpreters must cultivate interdisciplinary mindsets and skillsets. The purpose of this basic …

Intouch Week Of June 2, 2025, New York Medical College

InTouch

• NYMC Celebrates the Class of 2025 at 166th Commencement
• SOM Awards Ceremony Honors Excellence
• SHSP Dean’s Awards Recognize Rising Health Leaders
• GSBMS Honors Excellence in Biomedical Science at Annual Awards Ceremony
• TCDM Celebrates the Class of 2025
• Noninvasive Method for Early Intraventricular Hemorrhage Detection in Preemies Revealed

Enhancing The Acidic Activity Of D-Lyxose Isomerase By Molecular Modification Methods, Li Qiaoling, Hu Yang, Zhou Huiling, Yu Xun, Wen Li, Wu Hao

Food and Machinery

［Objective］ To improve the activity of D-lyxose isomerase under acidic conditions.［Methods］ Solvent -accessible surface bioinformatics analysis was performed on surface residues of D-lyxose isomerase derived from Caldanaerobius polysaccharolyticus,and six mutation sites,i.e.,K2D,K2E,K8D,K8E,K18D,and K 18E,were designed.Mutants were constructed and subjected to recombinant inducible heterologous expression in Escherichia coli.The recombinant mutant enzymes were isolated and purified using a nickel affinity chromatography column.In vitro comparative experiments were conducted to evaluate the catalytic conversion of D-fructose to D-mannose by the recombinant mutant enzymes at acidic pH 5.5 and near -neutral pH 6.5.［Results］］ The recombinant mutant enzymes K 8D and K 8E showed significantly improved catalytic …

Interaction Between Casein And Tlr 4 On Neutrophil Surface Based On Molecular Dynamics, Tang Yang, Jiang Fei, Zhang Bo, Wen Li, Xie Yufei

Food and Machinery

［Objective］ To explore the activation effect of casein (CN) on neutrophils and its interaction with TLR 4 receptors on the neutrophil surface.［Methods］ The zebrafish model is adopted to study the activation effect of CN on neutrophil migration,with such methods as 3D model construction,molecular docking,and molecular dynamics simulations employed to study the interaction between TLR 4 receptors and CN subtypes.［Results］］ Treatment of 3 dpf zebrafish with 1 mg/mL of CN solution for 2 h can induce neutrophil migration and accumulation inside the body of the zebrafish.All subtypes of CN can form stable complexes with TLR 4.It is speculated that the key …

Screening And Identification Of Pollution-Reducing Strains In Wastewater Processed By Freshly-Extracted Zanthoxylum Oil, Su Yanan, Qin Likang, Chen Mengping, Wu Qifeng, Min Fangqing

Food and Machinery

［Objective］ To isolate and identify highly effective strains capable of removing chemical oxygen demand (COD ) and ammonia nitrogen from antibacterial wastewater.［Methods］ Metagenomic sequencing technology is employed to deeply explore the microbial resources in wastewater isolated by freshly -extracted Zanthoxylum oil.The strains with the ability to efficiently remove COD and ammonia nitrogen are accurately analyzed.The strains with pollution -reducing potential are screened from wastewater enriched through natural outdoor cultivation for one month.［Results］］ Proteobacteria and Firmicutes are the predominant phyla in the wastewater isolated by freshly -extracted Zanthoxylum oil,while Enterobacter and Acetobacter are the dominant genera.Three strains with significant COD and …

Preparation Of Potato Protein Fiber By Trypsin Method And Its Structural And Functional Properties, Zhou Xiangjun, Li Miao

Food and Machinery

［Objective］ To investigate the preparation of potato protein fiber (PPF) based on enzymatic method,and further analyze their structural and functional properties.［Methods］ PPF is prepared from potato protein isolate (PPI) through enzymatic hydrolysis with trypsin (Tyr) and acid -heat treatment.The effects of protein mass concentration,heating time,Tyr activity,and heating temperature on the fluorescence intensity of PPF are studied.Structural properties of PPF are characterized by infrared spectroscopy,fluorescence spectroscopy,etc.With curcumin (Cur) as an encapsulated object,the encapsulation efficiency,loading capacity,thermal stability,and antioxidant activity of PPF -Cur complexes are investigated.［Results］］ During the fibrosis process of PPF,the β-sheet content increases from 28.12% to 32.29%,and the α-helix content increases …

Extraction , Purification , And Structural Characteristics Of Polysaccharide From Roasted Beans Of Coffea Arabica, Shen Xiaojing, Ye Renfeng, Gong Shuchun, Wang Hongsheng, Jiang Weiwei

Food and Machinery

［Objective］ To study the composition and structural characteristics of polysaccharides from roasted beans of Coffea arabica.［Methods］ Roasted beans of C.arabica were used as raw materials.The hot water extraction combined with alcohol precipitation method was optimized using the response surface methodology to extract polysaccharides.The crude polysaccharide was purified using the Sevag method,macroporous resin,cellulose column,and gel separation technology.Total sugar,total phenol,total flavonoid,and monosaccharide compositions were analyzed using the phenol -sulfuric acid method,Folin -Ciocalteu assay,NaNO2-AlCl3-NaOH method,and ion chromatography,respectively.The structural characteristics of the polysaccharides were characterized by infrared spectroscopy (IR) and scanning electron microscopy (SEM ).Additionally,the in vitro antioxidant activity of the polysaccharides was evaluated.［Results］］ …

Moderate Processing Of Wheat Based On Milling Procedures, Zhang Peijie, Ren Guangyue, Liu Wenchao, Fan Huiping, Zhang Debang

Food and Machinery

［Objective］ To investigate the production procedures for moderately processed wheat flour,with the aim of improving milling efficiency,reducing raw material loss,and enhancing flour quality.［Methods］ The milling process was conducted by regulating key steps (wheat conditioning,sifting,bran milling,and roll spacing adjustment ).Flour quality was comprehensively evaluated based on flour yield and flour characteristics to determine the optimal moderate processing procedure.［Results］］ The roll spacing adjustment -non-conditioning process yielded the highest flour output (72.05 g/100 g),representing an increase of 8.96% compared to the control group and 14.24% compared to the non -conditioning process.Moreover,the protein content of flour obtained through the roll spacing adjustment -non-conditioning method …

Comparison Of Cytotoxicity , Antioxidation And Hypoglycemic Activity Of Three Stilbene Compounds, Chen Ying, Zhang Chaobing, Chen Shaoqiang, Yan Rian, Chen Yongsheng

Food and Machinery

［Objective］ To explore the differences in cytotoxicity,antioxidant,and hypoglycemic activities of resveratrol,oxy -resveratrol,and piceatannol,three stilbene compounds with similar structures.［Methods］ The cytotoxicity,extracellular/intracellular antioxidant activity,and hypoglycemic activity of the three compounds are analyzed by Cell Counting Kit -8 (CCK -8),total antioxidant activity,cellular antioxidant stress ability,intracellular reactive oxygen species (ROS ) content,cellular antioxidant activity (CAA ) assay,and α-glucosidase inhibitory activity.［Results］］ Compared with oxy -resveratrol and resveratrol,piceatannol shows lower cytotoxicity,better extracellular antioxidant activity,and α-glucosidase inhibitory activity.All three stilbenes effectively mitigate the oxidative stress damage of HepG 2 cells induced by H2O2 solution and reduce the ROS content in HepG 2 cells in a dose -dependent …

Optimization Of The Preparation Process Of Cordyceps Militaris Polypeptides Through Fermentation Technology And Evaluation Of Antioxidant Activity, Xin Ting, Wang Zhao, Li Changbin, Zou Jian

Food and Machinery

［Objective］ To prepare Cordyceps militaris polypeptides using fermentation and analyze their antioxidant activity.［Methods］ The most suitable strain was screened from four candidates.Based on single -factor experiments and combined with orthogonal experiments,the fermentation process conditions of the selected strain were optimized.The polypeptide solution was separated and purified by ultrafiltration,and the antioxidant activity of C.militaris polypeptides was analyzed.［Results］］ The optimal conditions for preparing polypeptides from C.militaris protein by fermentation with Bacillus subtilis were as follows:3% addition of C.militaris protein,fermentation temperature of 36 ℃,inoculation amount of 4%,and fermentation time of 24 hours.Under these conditions,the polypeptide yield was 67.95%.After ultrafiltration,the fraction with a relative …

Effects Of Enzymatic Hydrolysis Combined With Spray-Drying On The Flavor Components And Powder Properties Of Dictyophora Rubrovolvata, Chen Jiaqi, Ming Jian, Li Jialin, Zeng Zebin, Shao Yi

Food and Machinery

［Objective］ To investigate the effects of enzymatic hydrolysis on the flavor components of Dictyophora rubrovolvata and the properties of its spray -dried powder.［Methods］ Dictyophora rubrovolvata is used as the raw material in this study.Detection is performed on its active substances and flavor components after enzymatic hydrolysis,as well as its powder properties after spray drying.［Results］］ Enzymatic hydrolysis promotes the dissolution of dictyophora polysaccharides,polyphenols,and flavonoids,as well as the release of soluble sugars,flavor nucleotides,flavor amino acids and flavor substances.GC -MS results showed that the volatile compounds in the samples increased from 42 to 53 after enzymatic hydrolysis,with a flavor profile dominated by floral,fruity,and …

Effects Of Four Extraction Methods On The Quality Of Arrowhead Starch, Ji Derong, Zhou Tingting, Wu Shan, Duan Lili, Wang Ruyu, Qiao Mingfeng

Food and Machinery

［Objective］ To compare the effects of four extraction methods (ancient method,wet method,alkaline method,and cellulase method ) on the yield and physicochemical quality of arrowhead starch.［Methods］ With fresh arrowhead taken as raw material,arrowhead starch is extracted by the four methods mentioned above.Then,the physicochemical properties of the starch are analyzed and compared.［Results］］ The yield of starch extracted by the wet method is the highest (9.17%),with the best freeze -thaw stability.The content of amylose is the highest in the starch extracted by the cellulase method (70.13%).However,for the starch extracted in this method,the granularity is relatively large and the surface is not smooth enough.The …

Research Progress On The Functional Activity And Mechanism Of Action Of Porcine Peptides, Chen Qian, Chen Hong, Ge Yuxi, He Xiaoyu, Fang Zhengfeng

Food and Machinery

Porcine tissues and organs are rich in proteins.Bioactive peptides hydrolyzed from porcine tissue and organ proteins have been proven to possess various physiological activities,such as blood pressure reduction,antioxidation,antibacterial effects,and bone growth promotion.Differences in substrates and processing conditions result in variations in the functional activity and molecular size of these peptides.This article focuses on the acquisition of porcine bioactive functional peptides,analyzing their amino acid composition and sequence to elucidate their mechanisms of action.Furthermore,it explores the commonalities among different peptide fragments exhibiting the same functional activity and discusses the application prospects of porcine bioactive peptides.

Progress In Chemical Composition , Efficacy , And Delivery Systems Of Plant Essential Oils, Huang Jialin, Bai Weidong, Liu Gongliang, Li Xiangluan, Wang Jingyuan, Wang Hong

Food and Machinery

Plant essential oils,a widely available class of natural products primarily composed of terpenes,oxides,lactones,alcohols,phenols,ketones,aldehydes,and other compounds,exhibit a variety of biological activities including antioxidant,antimicrobial,antitumor,anti-anxiety,and anti -inflammatory properties.In recent years,researchers have explored enhancing the stability and bioavailability of plant essential oils through the development of various delivery systems,including nano -emulsions,microemulsions,microcapsules and liposomes.The research provides a systematic review of the chemical composition,efficacy,and delivery modes of plant essential oils,and offers insights into their future development directions.