Digital Commons Network^™

Ion Channel Gating Probability Of Voltage-Gated Hnav1.1: Role Of Beta Subunits And The Associated Impacts On Epilepsy, Georgia Blue Hill, Soha Haniyyah, Diana M. Cortez, James R. Groome

Idaho Conference on Undergraduate Research

Voltage-gated sodium channels are essential for initiating action potentials in neurons. Mutations in the human brain sodium channel hNaV1.1 ion channel are associated with a large number of neurological disorders, such as epilepsy. Despite its clinical relevance, there is still much to characterize about the specific effects of how these mutations affect sodium channel behaviour, including the role of the smaller beta subunits. To investigate this, hNaV1.1 channels were expressed with varying beta subunits (beta 1,beta 2, or none) in Xenopus oocytes. Electrophysiology was utilized to record sodium currents and measure the probability of sodium channels activating (open state) or …

Exploring Dna Metabarcoding To Understand Diet In Declining Columbian Sharp-Tailed Grouse (Tympanuchus Phasianellus), Alexandria J. Serbellon, Jack Knutson, Morgan Calahan, Julia Parker, Stephanie J. Galla

Idaho Conference on Undergraduate Research

The Columbian Sharp-tailed Grouse (Tympanuchus phasianellus; hereafter CSTG) formerly occupied shrub-steppe ecosystems across western North America but now inhabit less than five percent of their former range due to habitat loss and other anthropogenic factors. Despite their social and ecological significance, research on CTSG diet has been limited, with the last comprehensive study taking place over 20 years ago. Understanding dietary habits is crucial, as food availability directly impacts population dynamics, local adaptation, and overall fitness of this species. Through the application of plant DNA metabarcoding (i.e., p6 loop of trnL) from non-invasively collected fecal samples, this …

How Does Irrigation Affect American Kestrel (Falco Sparvarius) Nest Site Selection And Parasite Infection?, Izzy C. Piedmont, Sarah E. Scott, Mackenzie G. Hutchinson, Stephanie A. Low, Julie A. Heath

Idaho Conference on Undergraduate Research

Irrigated agricultural lands can provide important habitat and forage locations for wild birds. The costs and benefits of irrigated agricultural areas compared to wildlands remain unclear. Green vegetation attracts insects and small mammals, creating an abundant food source for predators. In addition, the use of chemicals on crops may reduce vectors of disease. American Kestrels (Falco sparverius) are a small species of falcon that make extensive use of both irrigated and non-irrigated landscapes. We examined nest site selection and Haemosporidian parasite loads in a partial migrant population of American Kestrels in irrigated and non-irrigated landscapes. If irrigated lands …

Removal Of Senescent Cells Using Senolytics Attenuates Α-Synuclein-Mediated Parkinson's Disease Pathology, Payton Wardwell, Dinesh Kumar Verma, Yong-Hwan Kim

Idaho Conference on Undergraduate Research

Emerging evidence suggests that cellular senescence contributes to the progression of neurodegenerative diseases, including Parkinson’s Disease (PD). Cellular senescence is a state in which cells cease to proliferate in response to damage and contribute to tissue dysfunction through the release of toxic factors. While dopaminergic neurons are the primary cells lost in PD, senescent glia: astrocytes and microglia, are considered to play a vital role in regulating neuronal health. Using the pre-formed fibril (PFF) of alpha-synuclein to induce PD-like pathology, we examined the impact of senolytic treatment on glial cell senescence. Cellular senescence is assessed by measuring the levels of …

Transition Metal Phosphides And Pco Used To Sustainably Transfer Phosphorus In Energy And Electricity, Maya Hoffman, Chika Abonyi, Richard Thompson

Idaho Conference on Undergraduate Research

Transition metal PCO (P=C+O) complexes have potential uses to produce organophosphorus complexes in a much more efficient and sustainable manner. This project shows the synthesis, identification, and characterization of a Cu(I) PCO complex which is supported by a bulky N-heterocyclic carbene ligand (NHC*). This compound has been characterized via NMR (1H, 31P, 13C) and IR spectroscopy. Thermolysis of this compound shows the expulsion of carbon monoxide to generate a reactive Cu-P bond which appears to transfer the P-atom to the carbene ligand as gauged by NMR spectroscopy, as well as mass spectroscopy.

C-Terminal Frameshift Variants In Gpkow Are Associated With A Multisystemic X-Linked Disorder, Jung-Wan Mok, Laura Mackay, Maria Blazo, Elizabeth Mizerik, Jozef Gecz, Renee Carroll, Mathilde Nizon, Sophie Rondeau, Madeleine Joubert, Silvestre Cuinat, Wallid Deb, Fernanda Valle Sirias, Monika Weisz-Hubshman, Shamika Ketkar, Urszula Polak, Alyssa A Tran, Debra Kearney, Neil A Hanchard, Oguz Kanca, Michael F Wangler, Hugo J Bellen, Brendan H Lee, Shinya Yamamoto, Keren Machol

Duncan NRI Faculty and Staff Publications

Purpose: GPKOW, a gene on the X-chromosome, encodes a nuclear RNA-binding protein important in messenger RNA (mRNA) processing as a spliceosome subunit. This work aims to establish GPKOW as a disease-associated gene.

Methods: We describe 3 males from 2 unrelated families with hemizygous frameshift variants affecting the last exon of GPKOW p.(Arg441SerfsTer30) and p.(Ser444GlufsTer28). The effect of p.(Ser444GlufsTer28) on gene expression was evaluated in patient's fibroblasts. In vivo studies in Drosophila melanogaster targeting the sole GPKOW fly ortholog, CG10324 (Gpkow) were performed.

Results: Clinical presentations included intrauterine growth restriction, microcephaly/microencephaly, and eye, brain, skin, and skeletal abnormalities. Heterozygote females presented …

Sidesense: Robust Physiological Motion Detection Via Mmwave Joint Communication And Sensing Systems With Multiple Beams, Mohammed Shadman Ishrak, Jannatun Noor Sameera, Alvin Yang, Yanjun Pan, Yao Zheng, Olga Boric-Lubecke, Victor M. Lubecke

Electrical Engineering and Computer Science Faculty Publications and Presentations

A 28-GHz multibeam joint communication and sensing system called SideSense is presented, in which a line-of-sight (LoS) beam is used to maintain reliable communication, while other sensing beams are used to enhance physiological motion detection. SideSense decodes the motion frequency and shape from the channel state information (CSI) by first tuning the gain ratio and phase differences between the LoS communication beam and non-LoS (NLoS) beam to maximize the sensing signal-to-noise ratio (SSNR) without significantly degrading the communication channel capacity (CCC). Analytical results based on a bistatic model are presented to show a gain ratio of around 1 and a …

Surface Keratin 1, A Tumor-Selective Peptide Target In Human Triple-Negative Breast Cancer, Shih-Jing Yao, Farideh Amirrad, Elmira Ziaei, Azam Saghaeidehkordi, Moom R. Roosan, Kiumars Shamloo, Ajay Sharma, Rachita K. Sumbria, Surya M. Nauli, Christopher G. Bunick, Kamaljit Kaur

Pharmacy Faculty Articles and Research

Targeting drugs to cancer cells via overexpressed cell-surface receptors has emerged as an effective therapeutic strategy for several cancers. However, identifying cell-surface receptors that allow selective uptake of targeting ligands by cancer cells—while sparing normal cells—remains a challenge, especially for triple-negative breast cancer (TNBC), which lacks a well-defined receptor for targeted delivery. In this study, immunohistochemical (IHC) analysis revealed that human TNBC patient tissues have significantly higher levels of keratin 1 (K1) compared to normal breast tissues. Among TNBC tissues, grade 3 tumors showed significantly higher (threefold) K1 expression compared to grade 2 tumors. We analyzed human TNBC and normal …

Effect Of Ramadan Fasting On Lipid Profile And Bmi Among A Group Of Healthy Adult People In Mosul City/ Iraq, Safana Mohammed, Manal Rasheed

Iraqi Postgraduate Medical Journal

Background :- There is increasing interest regarding the health implications of Ramadan fasting in the recent years. Many reports indicate that fasting during the holy month of Ramadan results in reduced body weight and improved metabolic parameters like lipid profile in healthy individuals . Aim of the study :- To study the effect of fasting during the holy month of Ramadan on serum lipid profile and BMI in healthy adult volunteers. Subjects and methods :- prospective cohort study was done including a total of 50 healthy volunteers. Venous blood samples were taken from volunteer, 1week before Ramadan, and , in …

The Immunological Benefits Of Breast Feeding (Review Article), Ahmed Al-Harbi, Asmaa Shetawi

Iraqi Postgraduate Medical Journal

Breast feeding (BF) provides infants with the most suitable nutrients from birth tell weaning. The major part of mother breast milk (MBM) is water in which the other components dissolve. These components include nutrients and immune factors. The concentration of these components varies by time after delivery. Breast milk even provides infants with various types of bacterial species that contribute for development of infant microbiota.Components that are regarded important for shaping of infant immune response include different factors. MBM contains oligosaccharides which are associated with guts defenses, cytokines that participate in inflammation and immune cells activation, immunoglobulins that arm infant’s …

Ipm South Africa, Npc: Pioneering Hiv Prevention Options For Women, Ipm South Africa

Dapivirine Vaginal Ring (PrEP Ring)

The Population Council is leveraging its innovative ring technology to develop a range of next-generation prevention products that advance the science of HIV prevention. These include a three-month dapivirine-only vaginal ring as well as combination rings that leverage the potency of different ARVs.

There will be no single solution to ending the epidemic—stopping HIV will require a variety of options. Research from the family planning field has shown that when more options are available, women are able to choose what best fits their circumstance and life stage. This means that there is an urgent need to expand the number of …

Full Issue - Spring 2025 - Volume 112, Issue 1, Colby College

Colby Magazine

04. Planting Seeds to Grow a Stronger Community
16. Retiring Provost McFadden: Colby’s ‘Special Sauce’ is What Makes it Great
24. Pulver Scholars Explore Scientific Possibility
32. A Warm Wilderness Welcome for New Colby Students
42. Dare Northward is Shaping Colby as a Global Leader
48. Bringing Them All Back Home

Alfred Russel Wallace Notes 37. What About Wallace On Vaccination . . . ?, Charles H. Smith

Faculty/Staff Personal Papers

Best known for his natural history studies on evolution and biogeography, Alfred Russel Wallace (1823−1913) had a significant second career as a social critic. One of his most controversial stances was his position on (smallpox) vaccination. Anti-vaxxers of the present frequently bring up his name as a resource for their side, but the situation is not so easily reducible to that.

Copley Connects | Spring/Summer 2025, University Of San Diego

Copley Connects Library Newsletter

Message From the Dean | 2

Research and Scholarship Recognition | 3

Featured Collection: Southern Cross | 4

2025 Holleman Scholarship Winners | 6

AI Comes for Digital USD | 7

Pontem Partnership Marks Five Years | 8

Spotlight Jordan Kobayashi | 9

New Faculty at Copley | 9

ACRL Conference in Minneapolis | 10

American Society for Engineering Education (ASEE) Conference | 10

Copley Recognizes Graduating Seniors with Bookplates | 11

Top 10 Digital USD Downloads for the 2024–2025 Academic Year | 12

New Resources for Fall 2025 | 13

Seguimos Creando Enlaces Conference | 13

Copley Reads | …

Nsu Kpcom Link - Summer 2025 - Volume 4.2, Nova Southeastern University

NSU Florida Link Newsletter

No abstract provided.

Freeman Honors – The Annual Newsletter: Fall 2024-Spring 2025, Texas Southern University, Thomas F. Freeman Honors College

Honor's College Newsletters

Annual 2024-2025 Newsletter

A Link Prediction Model For Knowledge Graph Completion Of Traditional Chinese Medicine Cases, Qifeng Lou, Dongmei Mu, Shutong Wang, Lili Huang

Journal of Scientific Information Research

[Purpose/significance] To propose a link prediction model for completing the knowledge graph of Chinese medicine cases, aiming to fill in the missing information in the knowledge graph,reveal the potential unknown associations,and promote the construction of a more comprehensive and detailed knowledge graph of Chinese medicine cases.

[Method/process] Medical cases in the field of TCM asthma were collected and integrated to construct a knowledge graph of TCM asthma diagnosis and treatment. By introducing Dropout regularization and Batch Normalization techniques into the RotatE model, an improved ERDBN model is proposed and applied to the task of refining the asthma diagnosis and treatment …

Differential Privacy Enabled Deep Skin Image Classification Model Development, Prasun Kumar Mandal

Master’s Dissertations

Abstract In the era of big data, the explosive growth in data volume has significantly accelerated the development of deep learning. Deep learning is the most promising area of AI, yielding significant advancements in medical image classification. However, healthcare data contains important sensitive information and so privacy and security are crucial to preventing unauthorized access. Note that there are several data protection rules from multiple regulations to penalize any kind of data security violation, for example, the data protection principles (Article 5.1-2) and the data protection by design and by default (Article 25) of the General Data Protection Regulation from …

Transcripts With High Distal Heritability Mediate Genetic Effects On Complex Metabolic Traits., Anna L. Tyler, J Matthew Mahoney, Mark P Keller, Candice N Baker, Margaret Gaca, Anuj Srivastava, Isabela Gerdes Gyuricza, Madeleine J Braun, Nadia Rosenthal, Alan D Attie, Gary Churchill, Gregory W. Carter

Faculty Research 2025

Although many genes are subject to local regulation, recent evidence suggests that complex distal regulation may be more important in mediating phenotypic variability. To assess the role of distal gene regulation in complex traits, we combine multi-tissue transcriptomes with physiological outcomes to model diet-induced obesity and metabolic disease in a population of Diversity Outbred mice. Using a novel high-dimensional mediation analysis, we identify a composite transcriptome signature that summarizes genetic effects on gene expression and explains 30% of the variation across all metabolic traits. The signature is heritable, interpretable in biological terms, and predicts obesity status from gene expression in …

Undergraduate And Graduate Course Descriptions, Summer 2025, Wright State University

Course Descriptions

Wright State University undergraduate and graduate course descriptions from Summer 2025

Issue 14: Pulmonary & Critical Care Insider, Bharat Bajantri Md, Sarah Ellsworth-Hoffman Mls

Critical Care & Pulmonary

Pulmonary & Critical Care Insider Issue 14

Compiled by Bharat Bajantri, MD, and librarian Sarah Ellsworth, MLS for the clinicians of the Pulmonary and Critical Care team of Parkview.

The Pulmonary & Critical Care Insider newsletter was created by Dr. Bharat Bajantri, MD and Sarah Ellsworth, MLS in 2023 as a form of current awareness for current practice at our hospital, Parkview Health.

Topics: Original Study Summaries: stereotactic body radiotherapy, surveillance over surgery for small pulmonary subsolid nodules, EBUS-TBNA sample acquisition and handling, Systolic arterial pressure targets in shock, stroke risk after AF, methotrexate versus prednisone, corticosteroid use in community-acquired …

Summer 2025, Echoes Staff

Rose Echoes

No abstract provided.

Utilizing Pharmacogenomics To Improve Students' Self-Perception On The Interprofessional Competencies Of Roles And Responsibilities, And Teams And Teamwork, Amanda Brown, Moom R. Roosan, Robert Goldsteen, Scott D. Ochs, Reza Taheri

Pharmacy Faculty Articles and Research

Introduction

Pharmacogenomics (PGx) is an emerging discipline with the potential to revolutionize personalized medicine, but its successful implementation requires interprofessional collaboration. To address this need, a virtual interprofessional education (IPE) session was designed for student pharmacists and medical students to engage in a case-based learning experience.

Objective

The primary objective was to develop and implement an IPE activity focused on a patient case requiring PGx-guided dual antiplatelet therapy and to assess students' perceptions of two Interprofessional Education Collaborative (IPEC) Version 3 Core Competencies. A secondary objective was to identify key lessons from the session.

Methods

Pharmacist and physician faculty collaboratively …

Library News July 2025, Research Medical Library

Library News 2025

• What's New with Journal Impact Factors?
• Five Tips for Productive Writing from Faculty Members
• LibKey Nomad Now Integrated with Cabell's Predatory Reports
• On "Metastasis," "Metastases," and "Metastasize"

Atypical Beta Oscillatory Dynamics Are Related To Poor Procedural Learning In Children With Developmental Coordination Disorder, Jarrad A.G. Lum, Kaila M. Hamilton, Li Ann Leow, Welber Marinovic, Ian Fuelscher, Pamela Barhoun, Talitha C. Ford, Aron T. Hill, Samaneh Nahravani, Melissa Kirkovski, Peter G. Enticott, Christian Hyde

Research outputs 2022 to 2026

Procedural learning difficulties are commonly reported in children with developmental coordination disorder (DCD), yet the neural basis of this impairment remains unclear. This study addressed this gap by examining the correlation between cortical oscillatory activity and procedural learning of a sequence of finger movements in children with and without DCD. Participants were 19 children with DCD and 38 typically developing (TD) children, with a mean age of 10 years and 3 months. Children completed the Serial Reaction Time task, a standard measure of procedural learning, during which they unintentionally learned a sequence of finger movements. Electroencephalography (EEG) was continuously recorded …

A Perspective Or Review Based Entirely On Low-Quality Evidence Is Simply An Opinion, Matthew S. Tenan, Sophia Nimphius

Research outputs 2022 to 2026

No abstract provided.

Navigating Child Oral Health In Western Australia: A Caregiver's Perspective, Lesley Andrew, Elizabeth Wenden, Mohamed Estai, Ruth Wallace

Research outputs 2022 to 2026

Background: Early childhood caries (ECC) is the most common chronic health condition among Australian preschool-aged children. Untreated, ECC can affect children's physical and emotional health and future social opportunities. ECC is largely preventable through primary caregivers' correct understanding of oral health promoting diets, oral hygiene practices and dental service engagement. The study aim is to explore Western Australian (WA) primary caregivers' child oral health knowledge, experience and practices. The Fisher-Owens socioecological model of child oral health was applied across the study to structure and interpret the findings across the complex, interactive sociocultural influences on child oral health. Methods: The mixed-methods …

A Comparative Study Of The Pullout Strength Of Geostraps And Geogrids In Reinforced Soil, Kshitij Gaur, Ashutosh Trivedi, Sanjay Kumar Shukla

Research outputs 2022 to 2026

The sustainable development of geotechnical infrastructure necessitates using durable, efficient, and environmentally resilient reinforcement materials. This study investigates the pullout performance of geostraps to assess their potential as a sustainable alternative to conventional geosynthetics. This study focuses on the pullout performance of geostraps, flexible, polymeric reinforcement materials. There has not been a thorough study of their pullout resistance, which directly affects the stability and durability of reinforced soil structures. Pullout tests were conducted on sandy soil in a controlled environment. The experimental findings from the pullout test were then validated in a numerical model. The model was used to determine …

A Study On The Multifunctional Properties And Application Perspectives Of Zno/Sic Composite Materials, Mohammad Nur-E-Alam

Research outputs 2022 to 2026

ZnO/SiC nanocomposite materials possess significant potential for various technological fields due to their extraordinary optical, electrical, thermal, and mechanical properties. The synthesis methods, material properties, and diverse applications of ZnO/SiC composites have been systematically explored in this study. The potential application areas of this nanocomposite include their roles in photocatalysis, optoelectronic devices, gas sensors, and photovoltaic systems. The synergetic effects of ZnO and SiC are analyzed to highlight their advantages over their individual components. Future research directions must focus on the remaining challenges to optimize these nanoscale composite materials for industrial and emerging applications.

Blue Light Is A Key Factor In Regulating Stomatal Movement, Transpiration Rate And Aba Metabolism Under Varying Vapour Pressure, Sheona Noemi Innes, Sara Brunborg Jakobsen, Rikke Bryn Røsåsen, Haider Ali, Knut Asbjørn Solhaug, Jorunn Elisabeth Olsen, Sissel Torre

Research outputs 2022 to 2026

Vapour pressure deficit (VPD) and blue light (BL) are import signals for stomatal regulation and highly relevant during cultivation of economically important crops such as cucumber in controlled environments. However, the information about combined effects of VPD and BL and the regulation of abscisic acid (ABA) in this respect, is limited and seems to vary between species. This study investigated how moderate (1.12 kPa) or low (0.28 kPa) VPD combined with 5% or 30% BL affect the foliar ABA metabolism, transpiration rate, nutrient uptake, and growth in well-watered cucumber plants (Cucumis sativus ‘Quatro’). Additional BL, regardless of VPD, resulted in …