Mixture Effects On Metal Accumulation In The Asian Clam, Corbicula Fluminea, Mark A. Huff

Electronic Theses and Dissertations

Field collected Corbicula fluminea were exposed to trace level copper, lead, and zinc with the aim of examining the preferential accumulation between the soft tissue and shell. Metal levels were based on those in a permitted industrial effluent. At 1X effluent and 2X effluent exposure levels, copper was found to preferentially accumulate in the clam soft tissue, lead was found to preferentially accumulate in the clam shell, and zinc was found to excrete back into the diluent after preferentially accumulating in the clam soft tissue. When exposed as a mixture at 1X effluent levels, copper and lead were found to …

Isolation And Characterization Of Siderophore(S) From Pseudomonas Mosselii, Casey J. Stophel

Electronic Theses and Dissertations

Iron is essential for growth of most microorganisms. It functions as an important cofactor in many important biological processes. However, iron found in soil is rendered insoluble and unavailable to microorganisms for use. To overcome this, many bacterial species produce siderophores, a small organic molecule that has high affinity for iron. Siderophores allow for bacterial cells to obtain otherwise insoluble iron. Pseudomonas mosselii, a Gram negative bacterium, was isolated from a local soil sample. P. mosselii was found to produce siderophore(s) under iron restricted environment, however, they have not been characterized. Therefore, it was of interest to isolate, purify and …

Investigating The Impact Of Psychoactive Plant Alkaloids On Bumblebee Behavior, Skylar Mathieson

Electronic Theses and Dissertations

The relationship between plants and their pollinators is often framed as a food-for-service exchange in which plants provide pollinators with nutrients in exchange for transport of their gametes. However, in addition to essential nutrients, many floral rewards (nectar, pollen) also contain defensive toxins such as alkaloids, with largely unexplored consequences for plant-pollinator interactions. I investigated how three psychoactive and addictive plant alkaloids — caffeine, nicotine, and morphine — affect foraging behavior in generalist bumblebees (Bombus impatiens) using robotic flowers. Each of these chemicals affected pollinator foraging behavior, influencing the number and duration of their visits to flowers in …

Drivers And Consequences Of Changes In Nectar Microbiome Composition Across Spatial And Biological Scales, Daniel A. Barker

Electronic Theses and Dissertations

Microbial communities inhabiting floral nectar, known as the nectar microbiome, are important mediators of plant-pollinator interactions. However, the ecological and environmental factors that shape the composition of these microbial communities remain poorly understood. While previous studies have examined the effects of a few microbial groups, typically independent of one another, on one plant or pollinator species, this dissertation takes a wide-scale approach to explore how abiotic conditions and biotic interaction’s structure microbial communities within floral nectar. Furthermore, I also quantify how variation in microbial richness and identity influences pollinator behavior and plant reproductive success.

This dissertation shows that microbial abundance …

Post-Harvest Storage Of Fuzzy Cottonseed: Quality, Airflow Modeling, And Energy Use, Elijah T. Porter

All Theses

Fuzzy cottonseed is a valuable byproduct of the cotton ginning process. When cottonseed exits the cotton gin, it often retains high temperatures and moisture contents. Once in a storage facility, the cottonseed needs to be conditioned for safe storage. The overall objectives of this study were to analyze quality changes in cottonseed according to storage conditions, determine the airflow resistance properties of fuzzy cottonseed, develop a computational fluid dynamics (CFD) model of a representative cottonseed storage facility, and analyze cottonseed aeration fan strategies, runtimes, and costs. Changes in quality dictate the allowable storage time for cottonseed and are impacted by …

Effectiveness Of Electrosynthesized Hydrogen Peroxide In Urease Inactivation For Stabilization Of Source-Separated Urine To Recover Urea, Brooke E. Covert

All Theses

The practice of separating urine at a building scale, rather than mixing with domestic wastewater to be treated at water resource recovery facilities, allows for concentrated urine to be directly treated with the aim of resource recovery. However, source separation and treatment present challenges during separation, storage, and transport. This study evaluated the use of hydrogen peroxide-producing electrochemical cells, which represent a technology that uses electricity as an input, to stabilize urine through cathodically produced peroxide to enable downstream water and nutrient recovery. The electrochemical cells have been previously shown to stabilize urine with electrochemically produced peroxide as an effective …

Effect Of Cigarette Smoke Extract And Nutrient Deficiency On Energy Metabolism And Biosynthesis: An In Vitro Intervertebral Disc Explant Culture Study, Avery E. Madden

All Theses

Low back pain consistently ranks among the leading causes of disability worldwide, with degenerative changes in spinal intervertebral discs (IVDs) recognized as a key contributor. Degeneration arises from the disruption of mechanical and biological cues within the disc’s cartilaginous tissue, often exacerbated by aging or injury. In recent decades, cigarette smoking has also been identified as a significant risk factor, as IVD degeneration is more prevalent among individuals with a history of smoking. Smoke inhalation is thought to promote degeneration both directly, by exposing cells to water-soluble toxic chemicals in smoke; and indirectly, through nutrient deficiency resulting from vasoconstriction and …

Association Between Gene Family Expansion And The Rapid Diversification Of Pleurocarpous Mosses, Meredith A. Cobb

All Theses

Mosses are the second most species-rich group of land plants. They represent a critical group for understanding the evolution and diversity of land plants. Mosses comprise two major groups, acrocarps and pleurocarps. Despite having a more recent evolutionary origin than acrocarps, pleurocarps are exceptionally diverse. The difference in species richness reflects a rapid species diversification, roughly coincident with the origin and diversification of flowering plants. The speciation events giving rise to pleurocarp diversity happened so rapidly, making it historically difficult to produce strongly supported phylogenies with which to test evolutionary hypotheses. One such hypothesis is whether large-scale changes at the …

Determining The Impact Of Surface Roughness On Disinfection Efficacy Of Commercial Products Against Pseudomonas Aeruginosa And Staphylococcus Aureus Wet Surface Biofilms, Kayley Stallings

All Theses

Biofilms are resistant to many stressors including disinfectant treatments. Disinfection may be further complicated by biofilms formed on damaged surfaces, as the damaged parts provide bacteria a better place to attach and grow. To better understand the risks, a new method to standardize surface scratching, to emulate worn surfaces via surface roughness changes was developed. These surfaces were used to grow biofilms with an adapted standardized EPA method to determine disinfection efficacy differences on scratched and non-scratched high-density polyethylene (HDPE) and stainless steel (SS) coupons treated with commercial disinfectants [hypochlorite (CL)-based, hydrogen peroxide (HP)-based, and quaternary ammonium (QA)-based]. Post-80 grit …

Mammal Use Of Crossing Structures On Highways In The Southern Blue Ridge Mountains, Chloe E. Horton

All Theses

Road networks are a major driver of habitat fragmentation and wildlife mortality. Wildlife crossing structures (WCS) are a common mitigation strategy with the goal of maintaining landscape connectivity, reducing wildlife-vehicle collisions, and facilitating safe passage across highways. Most research on WCS prioritize large ungulates or carnivores, leaving potential gaps in our understanding of how diverse mammalian communities interact with these features. We investigated spatial, temporal, and behavioral patterns of small-, medium-, and large-bodied mammals using WCS in the southern Blue Ridge Mountains of North Carolina and Tennessee. Using remote camera data from structures on I-40 and I-26 collected from 2018 …

Biological Hydrogen Process Improvements By High Temperature Simultaneous Saccharification And Fermentation, Frank W. Jeffries V

All Theses

The hyperthermophilic bacterium Thermotoga neapolitana is established as a versatile organism for fermentative hydrogen (H₂) production. Batch experiments were carried out to investigate the cell yield, product yield, and kinetic parameter values for individual media containing five carbohydrates. The highest H₂ yield of 15.56±0.31 mmol-H₂/g-carbohydrate was reported for glucose medium. H₂ yield was measured to be 14.51±0.38, 14.44±1.15, 11.88±0.84, and 11.53±0.73 mmol/g for media containing xylose, cellobiose, arabinose and xylan respectively. Acetic acid yield followed a similar trend, where the obtained values were 0.470±0.01, 0.462±0.04, 0.431±0.01, 0.409±0.03, and 0.406±0.01 g-acid/g-carbohydrate for glucose, cellobiose, xylose, …

Small Stream Restoration In The Piedmont Of South Carolina: Comparison Of Evaluation Tools And Water Quality’S Effects On Salamanders, Camryn Lachica

All Theses

For many years, the United States Army Corps of Engineers (USACE) used the Guidelines for Preparing a Compensatory Mitigation Plan worksheets to guide pre-restoration evaluation and determine post-restoration mitigation credits in South Carolina. Recently, the USACE in South Carolina transitioned to the Stream Quantification Tool (SQT), which provides a more comprehensive assessment framework. Our first objective was to compare these assessment methodologies across different landscape types to determine what the SQT adds to mitigation calculations that were not considered in prior worksheets. We evaluated 16 streams in the Piedmont of South Carolina, with four replicates each of forested, suburban, urban, …

A Comparative Study Of Land Use Regulations And Impact On Coastal Estuaries, Mabel W. Dadzie

All Theses

The study presents a mixed method and longitudinal assessment of land cover change, estuarine land loss, and policy implemented to address the past and anticipated estuarine losses in the Cooper River and North and South Santee watershed over the past twenty years. This study uses National Land Cover Dataset from 2001 to 2021, NOAA’s SLR projection data and planning documents from 1990 to 2025 to examine policy evolution among ten major themes. The results illustrate significant changes in land cover, notably the transition of wetlands, agriculture, and forests to developed land, as well as an evident spike in the integration …

Striped Bass (Morone Saxatilis) Movement And Habitat Selection In The Edisto River, South Carolina, Jacob Hill

All Theses

Striped Bass (Morone saxatilis) are a commercially and recreationally important fish native to the Atlantic Coast of the United States. They possess a diversity of life history strategies, with northern populations tending to be anadromous and southern populations being primarily river residents. In general, southern populations are less studied, posing challenges for effective management. Between 2019 and 2024, we tagged 37 Striped Bass with acoustic telemetry transmitters in order to study seasonal migration patterns and summer habitat selection. We estimated migration probability for both the spring and fall Striped Bass migrations using data from an array of passive …

Supervised Machine-Based Learning And Computational Analysis To Reveal Unique Molecular Signatures Associated With Wound Healing And Fibrotic Outcomes To Lens Injury, Catherine Lalman, Kylie R. Stabler, Yimin Yang, Janice L Walker

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Posterior capsule opacification (PCO), a frequent complication of cataract surgery, arises from dysregulated wound healing and fibrotic transformation of residual lens epithelial cells. While transcriptomic and machine learning (ML) approaches have elucidated fibrosis-related pathways in other tissues, the molecular divergence between regenerative and fibrotic outcomes in the lens remains unclear. Here, we used an ex vivo chick lens injury model to simulate post-surgical conditions, collecting RNA from lenses undergoing either regenerative wound healing or fibrosis between days 1–3 post-injury. Bulk RNA sequencing data were normalized, log-transformed, and subjected to univariate filtering prior to training LASSO, SVM, and RF ML models …

Affinitytune: A Prompt-Tuning Framework For Few-Shot Anomaly Detection On Graphs, Jingyan Chen, Guanghui Zhu, Guansong Pang, Chunfeng Yuan, Yihua Huang

Research Collection School Of Computing and Information Systems

Graph anomaly detection (GAD) is a critical task with applications in domains such as networking, finance, and bioinformatics. % However, the scarcity of labeled anomalies and the limitations of unsupervised methods hinder effective detection. % While semi-supervised and few-shot learning approaches offer improvements, they struggle with knowledge transfer and rely heavily on labeled data. % Recent advancements in prompt tuning on graphs provide a promising direction, but their application to heterophilous graphs in anomaly detection remains underexplored. % In this work, we propose AffinityTune, a novel framework for few-shot graph anomaly detection based on prompt tuning. % Our approach introduces …

Transfusion-Related Acute Lung Injury (Trali): Current Understanding, Challenges, And Future Directions, Fahd A. Kuriri

Saudi Medical Journal

ABSTRACT Transfusion-related acute lung injury (TRALI) remains one of the most serious yet often overlooked complications of blood transfusion, contributing to significant morbidity and mortality worldwide. It manifests as acute respiratory distress and non-cardiogenic pulmonary edema within 6 hours of transfusion, requiring immediate recognition and intervention. However, diagnosing TRALI is complex, as its clinical presentation overlaps with other causes of acute lung injury, and its underlying mechanisms remain incompletely understood. This review examines the global burden of TRALI, shedding light on underreporting issues, particularly in resource-limited settings where surveillance systems are inadequate. It explores both antibody-dependent and antibody-independent pathways, focusing …

Investigating The Role Of Genetic Variations Of Abcb1 (Rs1045642) And Cyp7a1 (Rs3808607) Genes On Serum Lipid Level Among Malaysian Male Patients Treated With Atorvastatin, Muhammad U. Afzal, Naam B. Adeeb, Nur F. Musa, Dzul A. Noor

Saudi Medical Journal

ABSTRACT Objective: To explore the allele frequency and associations between the presence of single nucleotide polymorphisms (SNP) in the ABCB1 (rs1045642) and CYP7A1 (rs3808607) genes on lipid-lowering efficacy of atorvastatin among Malaysian male patients. Method: The study included 64 subjects from a previous genetic association study among male patients who were on atorvastatin. The study was carried out at HUSM, Kelantan, Malaysia from December 2023 to October 2024. The patients were split into 2 groups, each consisting of 32 subjects such as controlled (LDL level <3 mmol/L) and uncontrolled (LDL level >3 mmol/L). After genotyping each participant, the influence on their lipid profile was determined. Results: …

Effectiveness Of Epid-Based In-Vivo Dosimetry With Epigray® Software For Head And Neck Vmat Treatments, Ghassan Al-Murshedi, Yasmin Md. Radzi, Azhar Abdul Rahman

Saudi Medical Journal

ABSTRACT Objectives: To evaluate the effectiveness of in-vivo dosimetry (IVD) utilizing an electronic portal imaging device (EPID) in conjunction with EPIgray ® software (DOSIsoft, Cachan, France) for assessing the accuracy of dose delivery for the patient when undertaking head and neck (H&N) treatments. Methods: Using cross-sectional analysis, data were collected from the linear accelerator of twenty patients undergoing (H&N) radiotherapy treatments using the Volumetric Modulated Arc Therapy (VMAT) modality from June 2019 to October 2023 at Gleneagles Hospital Penang, Penang, Malaysia. EPIgray ® software reconstructed the delivered dose based on EPID images. These reconstructed doses were compared with the planned …

Computational Learning Across Biological And Industrial Systems: Bayesian And Segmentation Models For Epigenomic And Manufacturing Data, Prosenjit Roy

All Theses

In this thesis, we made a complete dual-domain investigation using a machine learning approach into two different scientific areas which were epigenetic analysis of seal species and pore identification in the work of additive manufacturing. The study showcased the flexibility and strength of modern computational tools in addressing complicated issues in various biological and industrial systems. We further investigated the epigenetics by using the Bayesian Neural Network and other machine learning methods to conduct a study on the DNA methylation pattern within three pinniped species (the northern elephant seal, Hawaiian monk seal, and Weddell seal) with perfect precision on species …

The Earliest University Of Nebraska Graduate Degrees, 1886-1909, Mark A. Griep

Mark A. Griep Publications

This list of the earliest graduate degrees awarded by the University of Nebraska (NU) in Lincoln was assembled to learn about the university’s research activity that preceded its admission to the prestigious Association of American Universities (AAU) in 1909.

Development Of A Machine Learning Framework For An Irrigation Decision Support System, Eric Wilkening, Derek M. Heeren, Yeyin Shi, Laila A. Puntel, Guillermo R. Balboa, Abia Katimbo, Kuan Zhang, Precious Nneka Amori, Bruno Lena

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Currently used irrigation scheduling techniques often require significant human intervention and are time consuming, particularly for variable rate irrigation. This research aimed to develop a conceptual framework that incorporates disparate data sources leveraging both mechanistic and machine learning (ML) approaches. The overarching objective is to utilize the growing availability of data and technology to manage irrigation more precisely, which will minimize negative impacts of irrigation on our water resources. An initial irrigation machine learning model was proposed and tested in this study as a key component of an edge-cloud computing and federated learning decision-making framework. The specific objectives were (1) …

Activation And Suppression Mechanisms Of The Nrg1 Helper Nlrs, Yu-Ru Wang, Ruize Zhang, Daowen Wang, Yong Wang, Zheng Qing Fu

Faculty Publications

No abstract provided.

Impact Of S-Phase Kinase Protien 2 Blockades On Hematopoetic Stem Cell Metabolism, Nicole Elmaraghy

Electronic Theses, Projects, and Dissertations

Hematopoietic stem and progenitor cells (HSPCs) quiescence is vital for the success of bone marrow transplantation, as it preserves long term self- renewal and prevents premature exhaustion (Takubo et al., 2013; Wilson et al., 2008). However, bone marrow transplant (BMT) failure remains a clinical challenge, often due to lack of long-term engraftment and insufficient stress reliance. Both of these characteristics are tightly linked to disrupted stem cell quiescence and metabolic imbalance (Anso et al., 2017; Vannini et al., 2016). One key player is S-phase kinase protein (SKP2), an E3 ubiquitin ligase that targets cell cycle inhibitors, like p27, for proteosome …

Semaphorin 3e-Plexin-D1 Pathway Downstream Of The Luteinizing Hormone Surge Regulates Ovulation, Granulosa Cell Luteinization, And Ovarian Angiogenesis In Mice, Hanxue Zhang, Jimmy Dhillon, Paul D Soloway, Bo Shui, Seoyeon Lee, Jennifer K Grenier, Paul R Munn, M Cecilia Ljungberg, Rebecca B Williams, Rainer B Lanz, Yu-Hsiang Liao, Yi A Ren

Faculty, Staff and Students Publications

Ovulation is induced by the luteinizing hormone (LH) surge and accompanied by granulosa cell luteinization and ovarian angiogenesis. Semaphorin 3E (Sema3E)-Plexin-D1 pathway regulates angiogenesis in other tissues, but its role in the ovary is unknown. Evidence indicates that Sema3E-Plexin-D1 pathway plays an important role in the mouse ovary. The expression of Sema3E and its receptor, Plexin-D1, is dynamically regulated in the mouse ovary downstream of the LH surge. This regulation requires the modulation of chromatin accessibility by CCAAT/enhancer-binding proteins α and β. Intraovarian injection of recombinant Sema3E results in reduced ovulation, impaired corpus luteum formation, and aberrant ovarian angiogenesis. These …

Prevalence Of Fibrosis In Hepatic Explants And Biopsies From Individuals With Urea Cycle Disorders, Saima Ali, Aisha Nisar, Anqing Zhang, Sandesh Nagamani, Nathalie M Aceves-Ewing, Brandy Rawls, Thu Quan, Greg Enns, John Goss, Daniel H Leung, Benjamin L Shneider, Shilpa Jain, Florette K Hazard, Deborah Schady, Lindsay C Burrage

Faculty, Staff and Students Publications

Background: Various forms of liver disease have been increasingly reported in individuals with urea cycle disorders (UCDs). In this study, we performed the first systematic and standardized histopathological assessment of the prevalence of fibrosis and steatosis in a large sample of hepatic explants and biopsies from individuals with UCDs at two liver transplantation centers.

Methods: Sixty-seven hepatic tissue samples from 66 individuals with UCDs were staged by two pathologists for hepatic fibrosis and steatosis using standard scoring systems at two large liver transplantation centers in the United States. Histopathological findings were correlated with clinical parameters, including UCD type, laboratory parameters, …

Effective Algorithm To Differentiate Nbs Mcadd Cases From Carriers And Non-Carriers And An Assessment Of The Utility Of The Second Newborn Screen For Mcadd, Matthew T Snyder, Kristian Divin, Ning Liu, Qin Sun, Yue Wang, Xi Luo, Yishay Ben-Moshe, Lindsay C Burrage, V Reid Sutton

Faculty, Staff and Students Publications

False positives are an inherent part of newborn screening that can increase both costs to the healthcare system and parental anxiety. Previous studies primarily examined presumptive positive rates for medium-chain acyl-CoA dehydrogenase deficiency (MCADD) in places conducting one newborn screen (NBS), with predominantly white, non-Hispanic subjects. Texas performs two NBSs and there is a majority Hispanic population in our region. This study aims to analyze biochemical and DNA data to more easily distinguish affected individuals from carriers or healthy non-carriers and identify benefits and challenges of a second NBS for MCADD. Biochemical and targeted DNA data from NBS dried blood …

Differences In Wait-List Mortality: Temporary Vs Durable Circulatory Support Devices, Mahwash Kassi, Salma Zook, Duc Nguyen, Katelyn Ingram, Sapna Legha, Rayan Yousefzai, Ju Kim, Imad Hussain, Cindy M Martin, Janardhana Gorthi, Adeel Ahsan Syed, Nadia Fida, Arvind Bhimaraj, Edward A Graviss, Ashrith Guha

Faculty, Staff and Students Publications

Background: In 2018, changes in the United Network for Organ Sharing (UNOS) allocation system led to a shift in practices, making durable left ventricular assist devices less desirable as a bridge to transplantation compared to temporary mechanical circulatory support. This study compares the composite outcome of waitlist mortality and delisting incidence at 1 year between these two support types.

Methods: All actively listed adult patients on mechanical circulatory support listed for heart transplantation under the current UNOS system from October 2018 to October 2021 were included, excluding those with right ventricular devices, biventricular devices, total artificial hearts, and extracorporeal membrane …

Insights Into The Molecular Mechanism Of Pulmonary Vein Stenosis In Pediatric Patients With Congenital Heart Disease, Alyssa B Kalustian, Pengfei Ji, Lalita Wadhwa, Christopher A Caldarone, Manish Bansal, Athar M Qureshi, Jeffrey S Heinle, Ravi K Birla

Faculty, Staff and Students Publications

Objective: Pediatric pulmonary vein stenosis (PVS) is associated with substantial morbidity and mortality for the subset of patients with recurrent or progressive disease. The molecular mechanisms underlying the development and trajectory of PVS remain unclear. This study characterizes the transcriptome of clinical and phenotypic subtypes of PVS.

Methods: Bulk RNA sequencing analysis was performed on human pulmonary vein tissue samples obtained from surgical interventions for pediatric patients with PVS. Transcriptomic profiles were compared for primary versus postrepair PVS as well as aggressive versus nonaggressive clinical phenotypes. Principal component analysis was performed, the differential gene expression quantified, and pathway analysis conducted …

Data-Driven Approach To Dynamic Resting State Functional Connectivity In Post-Traumatic Stress Disorder: An Enigma-Pgc Ptsd Study, Carissa W Tomas, Jacklynn M Fitzgerald, C Lexi Baird, Courtney C Haswell, Chadi G Abdallah, Michael Angstadt, Justin T Baker, Hannah Berg, Jennifer U Blackford, Josh Cisler, Andrew S Cotton, Judith K Daniels, Nicholas D Davenport, Richard J Davidson, Terri A Deroon-Cassini, Seth G Disner, Wissam El Hage, Negar Fani, Jessie L Frijling, Evan M Gordon, Daniel W Grupe, Xiaofu He, Ryan Herringa, David Hofmann, Ashley A Huggins, Ahmed Hussain, Jonathan Ipser, Neda Jahanshad, Tanja Jovanovic, Milissa L Kaufman, Yoojean Kim, Anthony King, Saskia B J Koch, Sheri Koopowitz, Amit Lazarov, Lauren A M Lebois, Isreal Liberzon, Shmuel Lissek, Antje Manthey, Geoffrey May, Katie A Mclaughlin, Laura Nawijn, Steven M Nelson, Yuval Neria, Jack B Nitschke, Bunmi O Olatunji, Miranda Olff, Matthew Peverill, Yann Quidé, Orren Ravid, Kerry Ressler, Marisa Ross, Lauren E Salminen, Kelly Sambrook, Chiahao Shih, Anika Sierk, Scott R Sponheim, Dan J Stein, Jennifer Stevens, Thomas Straube, Benjamin Suarez-Jimenez, Paul M Thompson, Nic J A Van Der Wee, Steven J A Van Der Werff, Sanne J H Van Rooij, Mirjam Van Zuiden, Dick J Veltman, Robert R J M Vermeiren, Henrik Walter, Xin Wang, Hong Xie, Xi Zhu, Sigal Zilcha-Mano, Christine L Larson, Rajendra Morey

Faculty, Staff and Students Publications

Using functional magnetic resonance imaging (fMRI), symptoms of posttraumatic stress disorder (PTSD) have been associated with aberrations in brain networks in the absence of a given cognitive demand or task, called resting-state networks. Prior work has focused on disruption in the static functional connectivity (FC) among specific regions constrained by a priori hypotheses. However, dynamic FC, an approach that examines brain network characteristics over time, may provide a more sensitive measure to understand the network properties underlying dysfunction in PTSD. Further, using a data-driven analytic approach may reveal the contribution of other larger network disturbances beyond those revealed by hypothesis-driven …