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Clonal Phenotype Mapping Reveals Genomic Alterations Underlying Tumor Immunosuppression During Immunotherapy, Er-Yen Yen

Dissertations and Theses (Open Access)

Tumors are dynamic ecosystems that evolve under selective pressures, shaping their ability to either elicit or evade immune responses. In pancreatic ductal adenocarcinoma (PDAC), where immunotherapy has yet to become an effective treatment option, we investigated the role of intratumoral heterogeneity in influencing immune interactions. Using orthotopic clonal replica tumors, we tracked clonal dynamics in response to anti-PD1 therapy and found that while treatment had limited impact on overall tumor volume, it induced profound shifts in clonal composition. Spatial lineage analysis of treatment-naïve tumors revealed that clones with distinct immunotherapy sensitivities occupy unique tumor microenvironments, a pattern that remained stable …

Chronic Cluster Headache Is A Rare Disease: Implications For Diagnosis, Treatment And Public Health, Hsiangkuo Yuan, Jan Hoffmann, Elena Ruiz De La Torre, Michael J. Marmura, Mario F. P. Peres

Department of Jefferson Headache Center Papers and Presentations

Cluster headache (CH) is a rare and painful primary headache disorder characterized by severe unilateral pain and cranial autonomic symptoms. This perspective examines the epidemiological evidence supporting the classification of chronic cluster headache (CCH) as a rare disease, noting a prevalence of CH of approximately 124 per 100,000 individuals, with only 3.5-13.7% manifesting CCH. This prevalence meets criteria established by both the US Food and Drug Administration and European Medicines Agency for rare disease designation. The rarity of CCH creates substantial clinical and research challenges, including prolonged diagnostic delays, limited research funding and a dearth of approved treatments. The economic …

Debunking Myths: Preparing Black Students Who Are Accelerated Learners For Postsecondary Opportunities, Erik M. Hines, Donna Y. Ford, Renae D. Mayes, Tanya J. Middleton, James L. Moore Iii, Desmond Mcglone

Journal of College Access

Black students are the most underrepresented in Gifted and Talented Education (GATE), Advanced Placement (AP), honors, dual enrollment (DE), and other programs for advanced learners (Ford, 2011, 2013; Hines, 2024; Hines, Fletcher et al., 2022). However, accelerated learners, particularly Black students, are usually seen as individuals who understand their educational trajectory, are more likely to know where they plan to attend college, and quickly know their career choice (Smith & Wood, 2020). Accelerated learners are students who are engaged in advanced coursework or programs such as Gifted and Talented Education (GATE), Advanced Placement (AP), honors, dual enrollment (DE). In this …

Predicting Case Clearance For Victims Of Anti-Transgender Homicide In The United States, Brittaney Alyssa Mann

Graduate Theses and Dissertations

There is a shortage of research exploring case clearance of anti-transgender bias homicides. This study will comparatively examine the similarities and differences in anti-transgender bias homicide cases with and without arrests at the victim, situational and incident levels occurring in the United States between 2013 and 2023. Data are extracted from the Bias Homicide Database (BHDB), the National Coalition of Anti-Violence Programs (NCAVP), and the Human Rights Campaign (HRC). This project will address the gap in understanding case clearance of anti-transgender bias homicides, provide policy implications, and ideas to further the discipline’s understanding of the topic. Keywords: LGBTQIA+ victims, bias …

Onair: Applications Of The Nasa On-Board Artificial Intelligence Research Platform, Evana Gizzi, Conner Firth, Caleb Adams, James Berck, P. Timothy Chase Jr., Christian Cassamajor-Paul, Rachael Chertok, Lily Cloug, Jonathan Davis, Melissa De La Cruz, Matthew Dosberg, Alan Gibson, Jonathan Hammer, Ibrahim Haroon, Michael A. Johnson, Brian Kempa, James Marshall, Patrick Maynard, Brett Mckinney, Leyton Mckinney, Michael Monaghan, Robin Onsay, Hayley Owens, Sam Pedrotty, Daniel Rogers, Mahmooda Sultana, Jivko Sinapov, Bethany Theiling, Aaron Woodard, Caroline Zouloumian

Computer Science: Student Work

Infusing artificial intelligence algorithms into production aerospace systems can
be challenging due to costs, timelines, and a risk-averse industry. We introduce
the Onboard Artificial Intelligence Research (OnAIR) platform, an open-source
software pipeline and cognitive architecture tool that enables full life cycle AI
research for on-board intelligent systems. We begin with a description and user
walk-through of the OnAIR tool. Next, we describe four use cases of OnAIR for
both research and deployed onboard applications, detailing their use of OnAIR
and the benefits it provided to the development and function of each respective scenario. Lastly, we describe two upcoming planned deployments …

Acute Exposure Of American Oyster (Crassostrea Virginica) To Selected Antidepressant Drug: Histological, Biochemical, And Immunohistochemical Assessments, Md. Faisal Amin

Theses and Dissertations

The rapid increase in pharmaceutical use has brought significant health benefits to humans. Studies have shown that many pharmaceuticals, such as antidepressants, are often detected in surface waters, groundwater, and even drinking water. These pharmaceuticals in aquatic environments threaten marine life seriously. Marine bivalves are vital source of seafood for people worldwide. In this study, we examined the effects of short-term exposure to fluoxetine, an antidepressant used to treat depression, at low (0.5 μg/L) and high (5 μg/L) doses over a one-week period on American oysters (Crassostrea virginica) under controlled laboratory conditions. Histological analysis revealed atrophy in the gills and …

The Role Of Nicotine In Treating Neurodegenerative Diseases, Jacquelyn T. Deaton

Graduate Student Dissertations, Theses, Capstones, and Portfolios

Neurodegenerative diseases have emerged as a critical medical challenge because they cause progressive neuronal death alongside structural or functional deterioration. Families, healthcare institutions, and affected individuals face significant challenges due to neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's diseases, which impair both cognitive function and motor abilities. Researchers have found that nicotine in tobacco products is a compound with therapeutic potential. This literature review explores how nicotine interacts with neurodegenerative mechanisms, such as oxidative stress and inflammation, and assesses its potential neuroprotective effects in conditions like Alzheimer's and Parkinson's diseases. In the central nervous system, nicotine binds to the …

Saliva & Circadian Rhythm In Medical Profiling For Early Disease Prevention, Joseph Lewis

Graduate Student Dissertations, Theses, Capstones, and Portfolios

Circadian rhythms affect almost every biological process from hormone secretion, gene expression, immune regulation, and metabolism. Studies show that disruption to these internal rhythms through irregular sleep, artificial sleep, and irregular sleep can significantly increase risk for chronic disease such as diabetes, cardiovascular disorders, neurodegeneration, and cancer. Saliva presents a viable alternative for capturing biomarkers found through blood or cerebrospinal fluid, offering substantial utility for diagnostic and chronobiological profiling. Saliva contains hormones such as cortisol and melatonin while containing inflammatory markers that fluctuate rhythmically throughout the day. Due to its ease of collection, saliva is well suited for longitudinal monitoring, …

Use Of Infrared Spectroscopy In Animal Studies: Aspects Of Health Science, Brian Manzanares

Graduate Student Dissertations, Theses, Capstones, and Portfolios

Non-invasive imaging technologies, such as infrared thermography (IRT), near-infrared spectroscopy (NIRS), and fourier-transform infrared spectroscopy (FTIR) are revolutionizing the field of animal research by enabling real-time, stress-free assessment of physiological conditions. Such methods like these are align with the ethical standards of the 3Rs, replacement, reduction, and refinement-by reducing the need of invasive procedures while enhancing data quality and animal welfare. These methods can also provide critical insight into animal health, behavior, and stress responses without the need for invasive procedures or restraint, thereby minimizing harm and distress. This literature review will explore the practical applications of IRT, NIRS, and …

The Role Of The Jnk Gene In Ovarian Cancer Inflammatory Pathways, Tashoy D. Campbell

Graduate Student Dissertations, Theses, Capstones, and Portfolios

Ovarian cancer, one of the leading causes of cancer-related deaths in women globally, presents a significant challenge due to its common late-stage diagnosis and chemoresistance (inability of the tumor to respond to drugs). The c-Jun N-terminal kinase (JNK) signaling pathway plays a crucial role in ovarian cancer progression, contributing to inflammation, tumor survival, metastasis, and chemotherapy resistance. This literature review examines the role of the JNK signaling pathway in ovarian cancer, with a focus on its role in inflammation, metastasis, and chemoresistance. JNK regulates key inflammatory cytokines, such as TNF-α and IL-6, which promote tumor growth and immune evasion. Moreover, …

Fluoride Toxicity And Benefit: An Integrated Review Of Mechanisms, Risks, And Public Health Impact, Sophia Chavarria

Graduate Student Dissertations, Theses, Capstones, and Portfolios

Fluoride has long been praised for its role in preventing dental caries, primarily through its effects on enamel remineralization and antibacterial effects. However, growing evidence from molecular and cellular studies suggests that excessive fluoride exposure, especially during tooth development, can lead to dental fluorosis and systemic toxicity. This paper examines the biological mechanisms underlying fluoride-induced dental fluorosis, with a focus on stress responses in ameloblasts, oxidative damage, impaired autophagy, and disrupted protein processing. It integrates data from in vitro, in vivo, and human studies to evaluate the cellular thresholds at which fluoride shifts from therapeutic to toxic. Systemic risks, including …

A Simple Guide For Describing Soils, 2nd Edition, Angela Stuart-Street, Nicolyn Short Dr, Paul Galloway, Noel R. Schoknecht

Natural resources published reports

Soils are enormously diverse and can be very confusing to understand and talk about. This simple guide for describing soils helps to identify the most important parts of a soil profile and provide an easy way to understand and explain what you see. It gives you a step-by-step guide of what soil properties to describe and how to describe them, along with the tools to make basic soil classifications. The soil descriptors help you to identify the soil type and aid in assigning a simple and standardised name to the soil. While this guide is designed to link with a …

Academic Persistence And Rural Social Work Students: An Analysis Of Factors Impacting Decisions To Persist, Samantha Perales

Social Work Doctoral Dissertations

Academic persistence of rural students in higher education remains a growing concern as institutions across the United States seek to address changing patterns and trends in enrollment and graduation rates, particularly in the aftermath of the COVID-19 pandemic. National trends show a relatively small increase in rural student enrollment. However, significant disparities in persistence and degree completion continue to exist between rural student populations and their urban and suburban counterparts. This study examines the factors that influence persistence among undergraduate social work students, specifically focusing on students from public, mid-sized universities in West Texas. Using a quantitative approach, the study …

Fsu Vip List 2025- Faculty Emeritus, Laura Mehaffey

Fayetteville State University- Speakers, Honorees, & Faculty Emeritus

This list catalogues those faculty and administration members who were named as Faculty Emeritus for Fayetteville State University.

A Nonstandard Neutrosophic Framework For Evaluating Intelligent Clothing Design Effectiveness Under Multisource Perceptual And Functional Uncertainty, Kaixia Zhuo

Neutrosophic Sets and Systems

No abstract provided.

Detection Of Activity Cliffs Produced By Anti-Cancer Drugs And An Algorithm For Reliable Predictions In Affected Areas, Sarah Josephine Aurit

Department of Statistics: Dissertations, Theses, and Student Research

An activity cliff (AC) occurs when drugs close in chemical space produce dissimilar biological results. We focus on developing an inferential procedure to detect the presence of ACs in a chemical landscape. If detected, we provide a distance-based procedure that can be used to identify regions of stability in the chemical landscape of interest and generate prediction with higher precision in those areas of stability. We conceptualize the chemical landscape as a spatial random field and use spatial models for prediction of efficacy for new drugs based on “distance” in chemical space. We argue that an AC manifests itself by …

Educational Attainment Patterns Among Mena Adults: A Comparative Study Of Native- And Foreign-Born Groups In The Us, Michael Okyere

Department of Sociology: Dissertations, Theses, and Student Research

This study examines educational attainment patterns among Middle Eastern and North African (MENA) adults in the United States, focusing on how nativity status, residential patterns, and gender shape these outcomes. Drawing on segmented assimilation and spatial assimilation theories, I analyze data from the 2018-2022 American Community Survey using ordered logistic regression models. Results indicate that educational attainment varies by gender, with MENA women consistently achieving higher education levels than men across all nativity groups, though this advantage varies considerably in magnitude between native-born and foreign-born subgroups. Residence in ethnic enclaves demonstrates a strong negative association with educational attainment among foreign-born …

Applications Of Preclinical Magnetic Resonance Imaging In The Treatment Of Traumatic Brain Injury And Understanding Carotid Artery Atherosclerosis, Evan Timothy Curtis

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Advances in magnetic resonance imaging (MRI) provide the opportunity to investigate research questions that have been left unanswered. In the cases of traumatic brain injury (TBI) and carotid artery atherosclerosis, MRI is a resource for non-invasively viewing the phenomena taking place. Additionally, potential interventions and treatments can be observed without harm to the subject. This dissertation expands the understanding of two preclinical applications of MRI: traumatic brain injury and carotid artery atherosclerosis in mouse models.

TBI is a leading cause of death and disability for individuals between 15–45 years of age and effective pharmaceutical interventions for treating the secondary damage …

Multimodal Deep Learning For Enhanced Breast Cancer Diagnosis On Sonography, Ting-Ruen Wei, Aileen Chang, Young Kang, Mahesh Patel, Yi Fang, Yuling Yan

Bioengineering

This study introduces a novel multimodal deep learning model tailored for the differentiation of benign and malignant breast masses using dual-view breast ultrasound images (radial and anti-radial views) in conjunction with corresponding radiology reports. The proposed multimodal model architecture includes specialized image and text encoders for independent feature extraction, along with a transformation layer to align the multimodal features for the subsequent classification task. The model achieved an area of the curve of 85% and outperformed unimodal models with 6% and 8% in Youden index. Additionally, our multimodal model surpassed zero-shot predictions generated by prominent foundation models such …

Structural Organization And Thermal Properties Of Polycaprolactone (Pcl) Nanofibers And Energetic Ionic Liquids (Eils) Investigated By Flash Differential Scanning Calorimetry (Flash Dsc), Aishorjo Paul Bablee

All Theses

This study explored the thermal behavior and structural organization of two materials, electrospun poly(e-caprolactone) (PCL) nanofibers and energetic ionic liquids (EILs). To this purpose, Flash Differential Scanning Calorimetry (DSC) has been used. Both materials are of significant interest for advanced applications such as biomedical devices, drug delivery, propellants, and energy storage due to their tunable physical properties and responsive thermal behavior.

The first part of the study investigated the structure-property relationship of electrospun PCL nanofibers, a biodegradable, semi-crystalline polymer widely used in biomedical applications. Cooling rates ranging from 0.1 to 2000 K/s and a fixed heating rate of 500 K/s …

The Role Of Cleavage And Polyadenylation Spcific Factor 6 (Cpsf6) In Hematopoiesis, Fengxi Ye

Dissertations and Theses (Open Access)

Cleavage and polyadenylation specific factor 6 (Cpsf6) translocation is frequently reported in APLL, which is Acute Promyelocytic Leukemia (APL)-like acute myeloid leukemia (AML) and other types of blood diseases associated with abnormal hematopoiesis. CPSF6 is a subunit of the Cleavage Factor I mammalian (CFIm) complex, which regulates post-transcriptional alternative polyadenylation (APA) of pre-mRNAs. Previous research indicated that Cpsf6 plays an essential role in alternative polyadenylation, development, and tumorigenesis. However, the role of Cpsf6 in hematopoiesis is unknown. Given its roles in APA, development and cancer, we hypothesize that Cpsf6 plays a critical role in hematopoiesis and that its …

Coastal Transition Zone Development Effects On Salt Marsh Ecology, Amanda Mei Pysher

Electronic Theses and Dissertations

The coastal transition zone (CTZ) is a regional gradient linking terrestrial and marine systems, comprising of the terrestrial upland, the marsh-upland ecotone, and estuarine salt marshes. Along all US coastlines, including the South Carolina (SC) coast from Little River to Georgetown, increases in anthropogenic development of terrestrial uplands have altered the historically established vegetation, and various physical, chemical, biological, and geological gradients. Despite the CTZ's ecological importance, the trickle-down effects of terrestrial upland development on associated high marsh habitats remain understudied. Data were collected from developed (DEV) and undeveloped (UND) shorelines across three SC estuarine inlets. Multilevel modeling (MLM) was …

Migratory Patterns Of Juvenile Shortfin Makos (Isurus Oxyrinchus): Evidence Of A Nursery In The Western North Atlantic, Julia A. Crews

Electronic Theses and Dissertations

Shortfin Makos, Isurus oxyrinchus Rafinesque, 1810, are lamnids that have a global distribution in temperate and tropical oceans. Locations of critical early life history events including birthing and nursery areas are unknown or unconfirmed for most populations. The objective of this study was to identify if a nursery area for Shortfin Makos in the northern waters of the Mid-Atlantic Bight using the criteria articulated by Heupel et al. (2007). Satellite tags were used to track the movement of juveniles (<200 cm TL, n=7) up to 5 months. Tag detections (n=882) confirmed that young makos stay in continental shelf waters of the northern Mid-Atlantic Bight off Long Island through the meteorological summer (June–August) and early meteorological fall (September–October) when sea surface temperatures are 18–23°C. There was clear migratory movement from juveniles once sea surface temperatures fell below 15°C. During late fall, some young sharks moved south towards Cape Hatteras, North Carolina, while one shark moved east up to 1,800 km into the open north Atlantic Ocean into meteorological winter. These movement data of juvenile Shortfin Makos combined with multi-year catches and sightings (2018–2024) provide strong evidence for a nursery area in the northern Mid-Atlantic Bight. By identifying a nursery area for Shortfin Makos, knowledge gaps that currently exist for this vulnerable species and support effective management can be closed.

Comparison Of Nutrient Concentrations And Primary Production Indicators Across Plume Fronts, Taylor Dishon

Electronic Theses and Dissertations

Coastal buoyant plumes carry low-salinity waters containing particulate and dissolved terrestrial materials with an abundance of nutrients into the coastal ocean, including inorganic nitrogen and phosphorous. Plume fronts act as transport barriers created from the convergence of a fresher plume with an older, saltier plume or with ambient waters, leading to potential accumulation of phytoplankton and nutrients. This accumulation creates an optimal environment for primary production. The primary goals of this study were: to investigate the distribution of and potential relationships between nutrient concentrations and chlorophyll a across plume fronts of the Winyah Bay River Plume, and examine potential relationships …

Site Fidelity, Seasonality, Movement, And Fish Associates Of Sand Tigers Carcharias Taurus In North Carolina, Ara L. Mcclanahan

Electronic Theses and Dissertations

Sand tigers Carcharias taurus are mackerel sharks with a disjunct global distribution in tropical and temperate seas. In the northwest Atlantic, sand tigers migrate along the coast of the eastern United States from the Gulf of Maine to Florida and occupy structurally complex benthic habitats. The long-term, underwater camera installation, SharkCam, at Frying Pan Tower, off Cape Fear, North Carolina, USA, sits atop an expanse of hard bottom reef frequented by sand tigers. The citizen-science platform Spot A Shark USA (SAS USA) uses images of sand tigers to identify and track individuals. This study utilized image encounters from SAS USA …

Adolescent E-Cigarette Expectancies: Measure Development And Preliminary Validity Of The Electronic Nicotine Vaping Outcomes Measure For Youth, Paul T. Harrell, Kelli J. England, Tracey E. Barnett, Vani N. Simmons, Richard W. Handel, Amy C. Paulson

Department of Pediatrics Faculty Publications

BACKGROUND: Electronic nicotine delivery systems (“e-cigarettes”) are the nicotine product most commonly used by adolescents. Research, treatment, and policy could benefit from measures of adolescent e-cigarette beliefs about outcomes of use (ie, expectancies). In the current study, we developed and tested an adolescent electronic nicotine vaping expectancy measure.

METHODS: A focus group with adolescents evaluated potential e-cigarette expectancy items. A panel of national experts assisted in revision of these items. Finally, items were administered to a sample of adolescents 14-17 years old (N = 267, Mean age 15.6, SD = 1.1, 50.9% Female, 50.2% Non-Hispanic White, 22.5% Non-Hispanic Black, 14.2% …

A Multi-Isotope Investigation Of Mammoth Diet, Habitat, And Movement Patterns In The Central Great Plains, U.S.A., Jacob Mccloskey

Department of Earth and Atmospheric Sciences: Dissertations, Theses, and Student Research

During the Last Glacial Maximum (LGM), the Great Plains in Nebraska consisted of wooded parklands and grasslands, whereas spruce (Picea) forests, parklands, and steppe grasslands dominated east of the Missouri River. I analyzed bulk carbon (δ¹³C), oxygen (δ¹⁸O), and strontium (⁸⁷Sr/⁸⁶Sr) isotopes from tooth enamel in isolated mammoth (Mammuthus) molars to compare diet and movement patterns in two late Pleistocene assemblages: one in Nebraska (n = 24), and one in western Iowa and Missouri (n = 17). Furthermore, I identified a morphometric subset of molars as …

Study Of Ai Applications In Biomedical Data Acquisition, Communication, And Analysis: Cest Mri Acceleration And Ecg Transmissions, Adarsha Bhattarai

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This dissertation investigates the application of artificial intelligence in biomedical data acquisition, communication, and analysis to advance neurological research and to enable the early detection of cardiovascular conditions. Despite significant advances in imaging and physiological modalities, challenges persist. Imaging modalities, such as the chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) technique are challenged by a prolonged data acquisition time and high operational costs. In addition, physiological modalities such as electrocardiogram (ECG) sensors face constraints in providing uninterrupted signal monitoring which is crucial for the timely detection of premature cardiac abnormalities. The primary goal of this work is to …

Evaluation Of Performance Characteristics And Groundwater Contamination Risks Associated With On-Farm Swine Carcass Disposal Via Composting And Shallow Burial With Carbon, Gustavo Castro Garcia

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This dissertation evaluates the performance of three on-farm swine carcass disposal methods: whole carcass composting (WCC), ground carcass composting (GCC), and shallow burial with carbon (SBC), focusing on biosecurity factors and groundwater contamination risks. Foreign animal diseases (FADs), such as African swine fever and classical swine fever, pose severe economic and animal well-being risks if introduced to the United States. With confirmation of an FAD, swine movement will be halted, creating an urgent need for practical, biosecure, and environmentally responsible on-farm disposal strategies for swine carcasses. Nebraska, as a leading swine-producing state, exemplifies the vulnerability of high-density livestock regions to …

Hormonal Modulation Of Sexual Approach And Avoidance Among Women With A History Of Sexual Trauma, Anneliis Susan Sartin-Tarm

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

A history of sexual trauma places women at a high risk for sexual dysfunction and other health sequelae, yet the influence of ovarian hormones in this population is poorly understood. This dissertation tested the theory that the effects of ovarian hormones are mediated by cognitive approach-avoidance systems to shape sexual well-being, and that this process is moderated by sexual trauma history. This was investigated across three studies examining the menstrual cycle, hormonal contraceptive use, and menopause. Across each chapter, I present complementary evidence demonstrating that hormones interact with the interpretation of ambiguous internal and external cues with respect to sexual …