Digital Commons Network^™

Synthetic Electrospun Fiber Matrix In The Management Of Acute Wounds Following Excision Of Hidradenitis Suppurativa Lesions: A Prospective Pilot Study, Michael Madueke, Frank Lau

School of Medicine Faculty Publications

Hurley Stage II or III hidradenitis suppurativa (HS) may necessitate surgical excision of diseased skin and subcutaneous fat for symptom control and disease management. These excisions result in open wounds in topographically challenging regions and typically cannot be primarily closed. This study evaluates the use of a synthetic electrospun fiber matrix (SEFM) as a post-resection regeneration template to accelerate re-granulation and improve subsequent skin graft incorporation. This prospective pilot study enrolled Hurley Stage II or III patients undergoing surgical resection of HS lesions. SEFM was applied to the resulting wounds in conjunction with negative pressure wound therapy (NPWT). Patients were …

Study Of Serum Interleukin-33 And Soluble St2 Levels, And Hla-B27 Typing In Iraqi Patients Of Ankylosing Spondylitis, Faris Ali Khdur, Hanaa N. Abdullah, Mayada Noori Iqbal

Baghdad Science Journal

Ankylosing spondylitis (AS) is a type of arthritis that causes inflammation in the joints and ligaments of the spine. The current study aimed to determine the level of serum interleukin-33 (IL-33), soluble stromelysin-2 (sST2) interleukin, and HLA-B27 typing among Iraqi AS patients. The whole blood samples of the patients were collected from medical hospitals in Baghdad city. The ELISA technique was used to measure the serum levels of IL-33 and sST2, and the HLA-B27 typing was performed by sequence-specific primer PCR (SSP-PCR). The patients were divided into patients newly diagnosed with the disease and patients receiving biological treatment (etanercept) in …

Exponential Domination Of Some Chemical Structures In Reduced (A, B)-Ka Indices, Anjaneyulu Mekala, U Vijaya Chandra Kumar, R. Murali

Baghdad Science Journal

Mathematical modeling with the help of numerical coding of graphs has been used in different fields of science, especially in chemistry for the studies of molecular structures. A special type of graph invariant called the topological index is the collection of data on algebraic graphs and provides a mathematical way to understand chemical structural features. In chemical graph theory, the topological index is a type of molecular descriptor calculated based on the graph of chemical compounds. Topological indices help us collect information about algebraic graphs and give us a mathematical approach to understand the properties of algebraic structures. With the …

Sars-Cov-2 Nsp13 Interacts With Tead To Suppress Hippo-Yap Signaling, Fansen Meng, Jong Hwan Kim, Chang-Ru Tsai, Jeffrey D Steimle, Jun Wang, Yufeng Shi, Rich G Li, Bing Xie, Vaibhav Deshmukh, Shijie Liu, Xiao Li, James F Martin

Faculty, Staff and Students Publications

The Hippo pathway controls organ development, homeostasis, and regeneration primarily by modulating YAP/TEAD-mediated gene expression. Although emerging studies report Hippo-YAP dysfunction after viral infection, it is largely unknown in the context of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we analyzed RNA sequencing data from human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) and SARS-CoV-2-infected human lung samples, and observed a decrease in YAP target gene expression. In screening SARS-CoV-2 nonstructural proteins, we found that nonstructural protein 13 (NSP13), a conserved coronavirus helicase, inhibits YAP transcriptional activity independent of the upstream Hippo kinases LATS1/2. Consistently, introducing NSP13 into mouse cardiomyocytes suppresses …

Occupational Health Equity: A Call To Consider Social-Structural Factors In Injury Prevention Research, Shannon Guillot-Wright, Elizabeth S Mcclure, Marizen R Ramirez, Alexis Grimes Trotter, David B Richardson

Faculty, Staff and Student Publications

Occupational health equity scholarship has been growing over the past decade, including social-structural determinants of health research that centres the voices and experiences of historically marginalised communities. In our commentary, we focus on the intersection of work-related and non-work-related factors and how they impact the health of workers, their families and their communities through community-engaged research. Case studies include the implementation of mobile clinics that are developed alongside communities, community organising to examine and reduce health disparities among racially segregated workers, the development of research instruments and measures to study racism and discrimination, and a focus on how the distribution …

Understanding Cancer Survivorship Care Needs Using Amazon Reviews: Content Analysis, Algorithm Development, And Validation Study, Liwei Wang, Qiuhao Lu, Rui Li, Taylor B. Harrison, Heling Jia, Ming Huang, Heidi Dowst, Rui Zhang, Hoda Badr, Jungwei W. Fan, Hongfang Liu

Department of Medical Oncology Faculty Papers

BACKGROUND: Complementary therapies are being increasingly used by cancer survivors. As a channel for customers to share their feelings, outcomes, and perceived knowledge about the products purchased from e-commerce platforms, Amazon consumer reviews are a valuable real-world data source for understanding cancer survivorship care needs.

OBJECTIVE: In this study, we aimed to highlight the potential of using Amazon consumer reviews as a novel source for identifying cancer survivorship care needs, particularly related to symptom self-management. Specifically, we present a publicly available, manually annotated corpus derived from Amazon reviews of health-related products and develop baseline natural language processing models using deep …

Groundwater Spatial Variability Within An Atoll Island: Assessing Shallow Aquifer Heterogeneity With Geophysical And Physicochemical Measurements, Nidia Tobon, Gerd Masselink, Tim O'Hare, Richard Bates, Ferdinand K. J. Oberle, Curt D. Storlazzi, Daniel Conley

Faculty of Science and Engineering Datasets

This study examines the spatial variability of shallow groundwater on Dhigelaabadhoo Island using Electromagnetic Induction surveys, groundwater monitoring, and sediment analyses. The research reveals how variations in island morphology—such as differences in elevation, reef flat width, and sediment composition—affect the spatial distribution of groundwater lenses and the overall aquifer dynamics. Dataset description: the dataset consists of five zip files. Each contains raw data for each sensor used in the study and a readme.txt file describing the data.

Adsl Deficiency Is A Secondary Mitochondrial Disease Affecting Organelle Homeostasis And Erk2/Akt Signaling In A Linear Genotype-Phenotype Relation, Matteo Bordi, Beatrice Testa, Claudia Compagnucci, Fiorella Colasuonno, Francesca Cipressa, Elisabetta Betterini, Andrea Mancini, Claudia Carsetti, Illari Salvatori, Caterina Ferraina, Ming Yang, Rossella De Cegli, Eugenio Del Prete, Chiara Veroni, Salvatore Rizza, Sofia Mauri, Elena Ziviani, Marina Macchiaiolo, Davide Vecchio, Filippo Maria Panfili, Teresa Rizza, Gerrit Weber, Rosalba Carrozzo, Alberto Ferri, Silvia Campello, Andrea Ballabio, Christian Frezza, Gianluca Cestra, Marco Tartaglia, Andrea Bartuli, Francesco Cecconi

Duncan NRI Faculty and Staff Publications

Adenylosuccinate lyase deficiency (ADSLd) is a rare autosomal recessive purine metabolism disorder with several clinical manifestations. While toxic substrate accumulation is a known hallmark, no additional molecular mechanisms have been established. Here, we show that ADSLd is associated with mitochondrial dysfunction, including increased fragmentation, impaired respiration, and reduced ATP production. The severity of mitochondrial impairment correlates with ADSLd pathology, especially in mitochondria-dependent tissues. We also identify defects in mitochondrial dynamics and transport linked to ERK2 and AKT suppression. Notably, overexpressing constitutively active ERK2 or supplementing purine intermediates partially rescues the mitochondrial phenotype. These findings suggest an alternative disease mechanism and …

Understanding Cancer Survivorship Care Needs Using Amazon Reviews: Content Analysis, Algorithm Development, And Validation Study, Liwei Wang, Qiuhao Lu, Rui Li, Taylor B Harrison, Heling Jia, Ming Huang, Heidi Dowst, Rui Zhang, Hoda Badr, Jungwei W Fan, Hongfang Liu

Faculty, Staff and Students Publications

Background: Complementary therapies are being increasingly used by cancer survivors. As a channel for customers to share their feelings, outcomes, and perceived knowledge about the products purchased from e-commerce platforms, Amazon consumer reviews are a valuable real-world data source for understanding cancer survivorship care needs.

Objective: In this study, we aimed to highlight the potential of using Amazon consumer reviews as a novel source for identifying cancer survivorship care needs, particularly related to symptom self-management. Specifically, we present a publicly available, manually annotated corpus derived from Amazon reviews of health-related products and develop baseline natural language processing models using deep …

Nrf2 Drives Activation-Driven Expansion Of Cd4+T Cells By Modulating Glucose And Glutamine Metabolism, Aprajita Tripathi, Debolina Dasgupta, Michael S. Dahabieh, Rachel Griffard-Smith, Anil Pant, Ashlyn Bugbee, Nanda Kumar Yellapu, Emily Burt, Ben H Y Choi, Abigail E. Ellis, Ryan D. Sheldon, Shailendra Giri, Devin Koestler, Russell G. Jones, Viveka Nand Yadav, Kalyani Pyaram

Manuscripts, Articles, Book Chapters and Other Papers

Upon antigenic stimulation, CD4+T cells undergo clonal expansion elevating their bioenergetic demands and utilization of nutrients like glucose and glutamine. The nuclear factor erythroid-2-related factor 2 (Nrf2) is a well-known regulator of oxidative stress, but its involvement in modulating the metabolism of CD4+T cells remains unexplored. We report that Nrf2 protein levels are temporally regulated in activated CD4+T cells, with elevated expression during early activation followed by a decline. T cell-specific constitutive activation of Nrf2, by deletion of its negative regulator Keap1, enhances early activation and interleukin-2 (IL-2) expression, upregulates T cell receptor (TCR) signaling, and increases activation-driven expansion of …

Rna/Dna-Binding Protein Tdp43 Regulates Dna Mismatch Repair Genes With Implications For Genome Stability, Vincent E Provasek, Albino Bacolla, Suganya Rangaswamy, Manohar Kodavati, Joy Mitra, Issa O Yusuf, Vikas H Malojirao, Velmarini Vasquez, Gavin W Britz, Guo-Min Li, Zuoshang Xu, Sankar Mitra, Ralph M Garruto, John A Tainer, Muralidhar L Hegde

Faculty, Staff and Student Publications

TDP43 is an RNA/DNA-binding protein increasingly recognized for its role in neurodegenerative conditions, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). As characterized by its aberrant nuclear export and cytoplasmic aggregation, TDP43 proteinopathy is a hallmark feature in over 95% of ALS/FTD cases, leading to detrimental cytosolic aggregates and a reduction in nuclear functionality in neurons. Building on our prior work linking TDP43 proteinopathy to the accumulation of DNA double-strand breaks (DSBs) in neurons, the present investigation uncovers a novel regulatory relationship between TDP43 and DNA mismatch repair (MMR) gene expression. Here, we show that TDP43 depletion or overexpression …

Assessing The Sustainable Circular Fashion Supply Chain As A Model For Achieving Economic Growth In The Global Market, Andrew P. Burnstine, Raouf Ghattas

Faculty and Staff Publications & Presentations

The fashion industry faces a critical sustainability crisis, contributing up to 10% of global carbon emissions and generating 92 million tons of textile waste annually. The study highlights the complex interplay of material flows, business models, power structures, and cultural mindsets, presenting a multi-scaled framework for advancing cleaner production and circularity in one of the world’s most resource-intensive sectors. This study proposes a transformative model for circular bioeconomy in fashion, integrating systems-change theory, degrowth economics, and emotional durability. Through case studies, including Patagonia, Eileen Fisher, and EU policy frameworks, the paper demonstrates how circular strategies can reduce waste, extend product …

Re: Butte Priority Soils Operable Unit (Bpsou) Final Insufficiently Reclaimed Sites Field Sampling And Investigation Plan (Fsp): Bres No. 100 – Capri Motel – Arctic Dump, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Humanization Of Cd47 Enables Development Of Functional Human Neutrophils Via Postirradiation Remodeling Of The Bone Marrow, Esen Sefik, Liang Shan, Et Al.

2020-Current year OA Pubs

Murine and human immune systems differ significantly, particularly within the myeloid lineage. Humanized mice, generated by transplanting human hematopoietic stem, progenitor cells into genetically modified mice, are invaluable to study human immune development and function in vivo. However, a major limitation of current models is suboptimal myelopoiesis, particularly lack of functional human neutrophils, hampering the modeling of human immune responses and chronic diseases. Here, we describe a humanized mouse model, named MaGIC for genes replaced, in the

Gata2 Mutation Is Associated With Immune Dysfunction And Increased Mycobacterium Haemophilum Susceptibility In Immunocompromised Individuals, Ananya Gupta, Shail B. Mehta, Abhimanyu, Bruce A. Rosa, John Martin, Mushtaq Ahmed, Shyamala Thirunavukkarasu, Farheen Fatma, Gaya K. Amarasinghe, Makedonka Mitreva, Thomas C. Bailey, David B. Clifford, Shabaana A. Khader

2020-Current year OA Pubs

Infections with nontuberculous mycobacterium (NTM) are on the rise. Here, we investigated an uncommon NTM infection, by M. haemophilum (Mh, n = 4), from a shared geographic location in the United States. All patients had underlying immunosuppressive conditions or treatments. We identified that all these individuals had a nonsynonymous mutation in GATA2 gene, which was absent in healthy controls (HCs, n = 4) from the same geographic area (Missouri, USA). Whole blood from these individuals had attenuated cytokine responses to Mh stimulation for IL-1β, IL-6, IL-8, MIP-1α and MIP-1β, but not to phytohemagglutinin (PHA) or another NTM, M. abscessus. Impaired …

The Effect Of Moringa Oleifera Leaves Powder Increasing The Productive Characteristics Of Common Carp (Cyprinus Carpio L.) Exposed To Chlorpyrifos, Hamid Hilal Farhan, Abid Ali Thaker, Hazem Sabri Abedalhammed

Baghdad Science Journal

Pesticides are a major global problem because of their effects on living organisms and their bodily functions. This study was conducted from August 25, 2022, to October 25, 2022. It aimed to know the toxic effects of Chlorpyrifos on common carp (Cyprinus carpio L.), and the potential of Moringa oleifera leaves to reduce this toxicity by evaluating their effect on growth performance in fish exposed to the pesticide. The LC50 for Chlorpyrifos has been estimated at 0.60 mg/L over 96 hours. Use 1/10 of the LC50 in the pesticide toxicity test treatment; Moringa leaf powder (MOL) was also added …

Sources, Distribution And Ecological Risk Assessment Of Polycyclic Aromatic Hydrocarbon In Sediment Of Tigris River, Iraq, Shahad R. Zaki, Maysoon Hassan Meshjel, Abdul Hameed M.J. Al-Obaidy

Baghdad Science Journal

Sediment samples were collected from five sites at Tigris River from Baghdad to Wasit Governorates River from December 2021 to November 2022. Sixteen polycyclic aromatic hydrocarbons (PAHs) in these sediment samples were analyzed. The results show that the total PAH concentrations ranged from 957.37 to 1805.05 μg/kg dry weight (dw) with mean values of 1368.034 μg/kg. Furthermore, the high molecular weight compounds (four, five, and six rings) of PAH in the analyzed sediment samples suggest that combustion sources such as fuel, gasoline, and vehicle emissions are the primary sources of PAHs in the environment. The sediment quality guidelines …

Impacts Of Stevia Rebaudiana Leaf Aqueous Extract On Some Physiological Parameters And Fertility In Male Albino Mice, Zainab K. Altmimi

Baghdad Science Journal

The objective of the work is to examine the impacts of Stevia leaf aqueous extract, after chronic administration (60 days), on some physiological aspects and fertility in male albino mice. .twenty-four adult e mice were categorized into four groups, each involving six animals. Three treatment groups were separately exposed to three respective concentrations of the extract (25, 50, and 100 mg/kg), he remainder is a control group. The animals were given daily oral doses of 0.1 ml/ 10 gm body weight of the group-respective extract concentration for 60 consecutive days. Several physiological and fertility-related parameters were tested based on the …

A Numerical Approach To Time-Space Fractional Stochastic Diffusion Equation, Archana Mourya, Kalyanrao Takale, Shrikisan Gaikwad

Baghdad Science Journal

The primary objective of this paper is to propose a Crank-Nicolson scheme tailored to analyze a time-space fractional stochastic diffusion equation subject to additive noise. Using the Caputo definition for time fractional derivatives and the shifted Grunwald-Letnikov definition for space fractional derivatives, a fractional order Crank-Nicolson finite difference scheme is devised to obtain a numerical solution. Considerable attention has been paid to examining the stability and convergence properties of this fractional order Crank-Nicolson method. To validate the effectiveness of the developed method, a comprehensive investigation using a test problem is conducted to assess its accuracy. The study harnesses the power …

Hybrid Path Planner For Centralized Multi-Robotic Long-Vehicle Based On Adaptive Dimensionality And Grey Wolf Algorithm, Noor Kadhim Ayoob, Ali Hadi Hasan

Karbala International Journal of Modern Science

The present robot planning methods pay no attention to the impact of the robot's size and the space it occupies in the environment on path planning. This paper presents a centralized hybrid method to plan optimal paths for multiple robotic long vehicles (RLVs) competing with each other to reach one common goal, taking into account the space that must be available to the RLV at each step to avoid narrow spaces that are too small to pass through. The environment analysis for each RLV is improved by assigning constant weight to the obstacles and calculating two new parameters: safety (SF) …

Revolutionary Technologies To Extend Lifespan And Personalize Medicine, Xavier Pillet

Defensive Publications Series

This document, produced with the assistance of ChatGPT o3 and GPT-5 Thinking, is released under the Apache 2.0 license. It is a voluntary defensive publication (prior art) and therefore enters the prior art upon release under the applicable patent statutes: EPC Art. 54(2) (European Patent Convention), French IPC/CPI Art. L 611-11 (French Intellectual Property Code), 35 U.S.C. §102(a) (United States Patent Act), Chinese Patent Law Art. 22(5) (中华人民共和国专利法), and Japanese Patent Act Art. 29(1) (特許法). It consolidates 100 enabling embodiments spanning gold nanomedicine (photothermal ablation, CRISPR-Gold delivery, nanozymes, theranostics), whole-body sensing (MRI, OPM/EEG, exposome), imaging/reconstruction (photoacoustics, DECT, PCD-CT), AI (digital …

Community Programming And Faith Communities: The Challenges And Impacts Of Civil Rights Education Programming Through The National Endowment For The Humanities Created Equal Grant, Andrea Shan Johnson, Roy A. Fisher

Journal of Community Engagement and Higher Education

We reflect on our experience using a faith community to host a civil rights film screening and discussion series. Hosting civil rights education events in a religious setting was a challenge due to the lack of integration in many faith communities, and the limited resources of the congregation. The short-term results include increased awareness of the history of civil rights struggles, which led to greater understanding of current events for members of the congregation.

Students’ Knowledge And Perceived Confidence In An Interdisciplinary Experiential-Learning Environment, Adam J. Kuban, Michelle M. O'Malley, Lee J. Florea

Journal of Community Engagement and Higher Education

Experiential-learning theory suggests that students acquire knowledge through hands-on learning environments, and aspiring journalists need a setting where they can experience science—its process(es) as well as how to report empirical findings. Researchers used pre/post questionnaires, field notebook evaluation, and focus group analysis as methods to assess an interdisciplinary, experiential course that combined science and media undergraduates. Results revealed students valued procedural over fact-based knowledge. Students also indicated increased perceived confidence—even when they answered questions incorrectly.

Reconsidering The American Dream And U.S. Latino Culture In A College Spanish Service-Learning Course, Zak K. Montgomery, Serena B. Ugoretz, Sarah E. Montgomery, Sarah Vander Zanden, Ashley Jorgensen, Mirsa Rudic

Journal of Community Engagement and Higher Education

This study explores how a joint Photovoice project about the American Dream between a U.S. Latino culture course and a multicultural middle school class influenced college students’ perceptions of Latino culture. In addition to outlining the service-learning course design, the study also analyzes the trajectory of the students’ understanding of the American Dream. As a result of the partnership, college students’ American Dreams shifted away from the archetypal personal success narrative toward a more civically- oriented approach.

Education Through Design For Social Empowerment, Lorenzo Imbesi, Luca D'Elia

Learn X Design Conference Series

The critical framework of education through Design-based practices emphasizes hands-on, experiential learning and its role in expanding STEAM education models. This approach leverages enabling technologies, such as digital fabrication tools, to provide transformative educational experiences that address societal challenges. This contribution explores how Design-based educational practices can serve as tools for social empowerment in marginalized communities, specifically examining the integration of STEAM methodologies with digital fabrication technologies to address educational poverty and foster social inclusion. The study discusses a case study focused on eight workshops in Ostia Ponente, where collaboration between universities, local authorities, and social organizations sought to combat …

A Post-Anthropocentric Creative Mindset Through Design Education, Eva Monestier, Marita Canina

Learn X Design Conference Series

Planet Earth is experiencing profound and irreversible transformations caused by the ongoing climate crisis. Simultaneously, technological advancements often create a misleading belief that these complex issues can be solved through with simple tech-fixes. However, to address the root causes of unsustainability, a radical shift in mindset is necessary. It is essential to challenge anthropocentric Euromodern narratives based on binary categories (nature-culture, humans-nonhumans), which have historically perpetuated detachment from the environment. Instead, a more relational understanding of reality is needed - one that positions humans and nonhumans within a more-than-human web of life. This shift necessitates the development of new design …

Bridging Silos: The Impact Of An Interdisciplinary Learning Community, Fabio Tellez, Richard Elaver

Learn X Design Conference Series

This paper presents a reflective case study of DigiFab, an interdisciplinary faculty learning community at Appalachian State University (North Carolina, USA), which explores the integration of digital design and fabrication into teaching, research, and creative endeavors. From 2019 to 2024, sixteen faculty and staff from diverse disciplines participated in monthly meetings that featured hands-on demonstrations, reflective discussions, and collaborative projects, including a collective exhibition. Data were collected through participant observation and a survey, and were analyzed using thematic analysis. Five key impacts emerged: teaching methods evolved as members transitioned from observation to AI integration; research and creative work expanded through …

Designing Design Energetics, Bruce Tharp

Learn X Design Conference Series

This letter is a call to those interested in the future of design and design education, and open to challenging the dominant materialist/physicalist paradigm. With advancements in quantum science, plasma physics, and wave mechanics, new understandings and models have arisen that offer professional and academic opportunities. Design, especially of physical, three-dimensional artifacts, sees objects as essentially vehicles for valuable subjective experience. What are the implications of acknowledging that all matter is actually congealed energy, and that all people are composed of, surrounded by, and affected by frequencies? How might designers better understand and address positive resonances and negative dissonances within …

Is Industrial Design Education Prepared For Industry 4.0?, Christoph Koch, Blair Kuys, Gianni Renda

Learn X Design Conference Series

This article explores the current state of industrial design in relation to future manufacturing technologies and paradigms. To date, no empirical research has been conducted that specifically examines the role of practising industrial designers in relation to their understanding and preparedness for technologies and systems as part of the next manufacturing revolution—Industry 4.0. As industrial design historically emerged in response to mass production, its continued relevance depends on how the profession evolves alongside technological transformation. We argue that changes in current production influence the development of the design profession and therefore its education. Although new technologies and systems are being …

Leveraging Neurodivergent Design Students To Co-Design Education And Develop A Resource For Inclusive Teaching, Karina Bhattacharya, Sabir Khan

Learn X Design Conference Series

This research advocates for a shift towards inclusive teaching practices in industrial design education. Neurodivergent industrial design students and recent graduates were leveraged as experts in their lived experiences to promote inclusivity. This study investigates what recommendations the neurodivergent participants could co-design toward inclusive teaching practices. Seven participants (graduate design students) from a North American institution were asked to share their background, comment on the state of industrial design education, and articulate what an inclusive version could be in the future through interviews and co-design workshops. Thematic analysis revealed 6 themes: (1) Interest: engaging in projects that interested them, (2) …