Digital Commons Network^™

Plastic Pollution In The Arctic Region And International Rules : Applicability And Limitations, Zhanfeng Lang

World Maritime University Dissertations

No abstract provided.

The Ratification And Implementation Of The International Maritime Organisation (Imo) Instruments : A Social And Policy Persepctive On Maritime Governance In Fiji, Miriama Latianara

World Maritime University Dissertations

No abstract provided.

Technology Transfer In The Implementation Of The Biodiversity Beyond National Jurisdiction Agreement, Christine Nzambi Mulatya

World Maritime University Dissertations

No abstract provided.

An Assessment Of Seafarer Social Security In Nigeria On The Implementation Of Mlc, 2006 Convention, Eshidenang Francis Owan

World Maritime University Dissertations

No abstract provided.

The Problem Of Noise Pollution In Chinese Waters : Can The Current National Legal Framework Tackle The Problem?, Zhou Wang

World Maritime University Dissertations

No abstract provided.

Preparedness And Response To Oil And Biofuel Spills : A Case Study Of The Western Indian Ocean, Soifoine Abdillah

World Maritime University Dissertations

No abstract provided.

Towards Zero Emissions Ports In Saudi Arabia : Drivers, Barriers, And Opportunities, Saad Hulil S Alshahrani

World Maritime University Dissertations

No abstract provided.

Resilience Of Indonesia As A Flag State : Analysis Of Key Determinants And Vessel Performance Trends In Psc Mou, Ridho Budiman

World Maritime University Dissertations

No abstract provided.

Maritime Risk Management Of Methanol Bunkering : Study On Key Points Of Ship Supervision And Inspection, Baozhong Li

World Maritime University Dissertations

No abstract provided.

Integrating Environmental Impact Assessment Into International Shipping Governance : A Bbnj-Pssa Synergy Framework, Thi Thuy Linh Pham

World Maritime University Dissertations

No abstract provided.

Combating Illegal, Unreported And Unregulated (Iuu) Fishing In Argentina : Role Of Argentinian Coastguard As Maritime Authority In Charge Of Law Enforcement, Mario Damian Tiscornia

World Maritime University Dissertations

No abstract provided.

Assessing Spatial And Temporal Patterns Of Industrial Bottom Trawlers Using Vessel Monitoring System Data : A Case Study Of Ghana, Emmanuel Agbeko

World Maritime University Dissertations

No abstract provided.

Evaluating The Implementation Of The Ballast Water Management Convention In Nigeria : The Possible Contribution Of The Experimentalist Governance Approach, Muhammad Ahmad

World Maritime University Dissertations

No abstract provided.

Assessing The Economic Impacts Of The Illegal, Unreported And Unregulated Fishing On The Namibian Coastal Communities : Challenges And Mitigation Strategies, Susana Kashinashilonga Angula

World Maritime University Dissertations

No abstract provided.

A Gap Analysis Of The Legal Framework For Oil Spills : Management In Nigeria, Yetunde Ajoke Idris

World Maritime University Dissertations

No abstract provided.

Governance In Nigeria’S Extended Continental Shelf : Implications For Domestic Regulation, Mark Terver Mailumo

World Maritime University Dissertations

No abstract provided.

Evaluating The Fisheries Observer Program Of Guyana’S Seabob Trawl Fishery : Insights Into Scientific Aspects And Onboard Working Conditions, Kadesha Shawyana Nedd

World Maritime University Dissertations

No abstract provided.

The Role Of Marine Spatial Planning (Msp) In Managing Conflicts Between Marine Resource Users In Tanzania, Ramadhani Juma Shausi

World Maritime University Dissertations

No abstract provided.

Strengthening Thailand’S Ship-Sourced Oil Spill Management : A Comparative Analysis Of Legal And Response Frameworks In Thailand, The United States, And Singapore, Supranee Wattanapongsakul

World Maritime University Dissertations

No abstract provided.

Skrmetti Beyond Scrutiny, Kate Redburn

Faculty Scholarship

In United States v. Skrmetti, the Supreme Court upheld Tennessee Senate Bill 1 (SB 1), a state law that prohibits transgender minors from accessing gender-affirming care. For the first time, the Court considered a fundamental question in civil rights law: How does the Fourteenth Amendment regard transgender people? The Court gave little guidance. It did not sort out principles for deciding when anti-transgender discrimination classifies by sex, nor whether transgender people are a suspect class. Instead, the Court held that “[i]n the medical context, the mere use of sex-based language does not sweep a statute within the reach of …

Recycling Waste Via Insect Agriculture: Frass Impacts On Soil And Plant Health, Helen C.S. Amorim, Amanda J. Ashworth, Thomas F. Ducey, Valerie B. Brewer-Gunsaulis, Gerson L. Drescher, Philip R. Owens, Alana H. Patterson, Giovanna De Blais, Iris Van Straaten

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Frass-the main by-product of insect rearing for animal feed-is emerging as a promising soil amendment and plant growth promoter. However, basic agronomic information is lacking and prevents frass' widespread use as a biofertilizer. This study assessed impacts of black soldier fly (Hermetia illucens L. [Diptera: Stratiomyidae]) frass on soil fertility, crop growth, and quality compared to poultry litter (PL). Irrigated and non-irrigated soybean (Glycine max L. Merr.) and non-irrigated switchgrass (Panicum virgatum L.) plots received either PL (5.6 Mg ha(-1)), low frass rate (LF; 5.6 Mg ha(-1)), high frass rate (HF; 11.2 Mg ha(-1)), besides the unamended control (CT). In …

Potentially Toxic Metals, Anthropogenic Microfibres And Other Microplastics In Sediments From A Small, Urban Estuary (Plym, Southwest England), Kwong Ricky Li, Andrew Turner

School of Geography, Earth and Environmental Sciences

Anthropogenic microfibres (AMFs) and microplastics (MPs) are pervasive and ubiquitous environmental contaminants of growing concern. However, their study in geosolids, like sediments, is often conducted in the absence of other important geochemical and anthropogenic markers. In the present study, surface and subsurface sediments from the Plym Estuary, southwest England, have been analysed for AMFs and MPs along with organic matter (as loss on ignition; LOI), calcium, iron, manganese and potentially toxic metals (PTMs). The latter were heterogeneously distributed throughout the estuary because of multiple inputs and variations in sediment granulometry. AMFs were mainly constructed of cellulosic and petroleum-based polymers and …

Determining The Accumulation Potential Of Nanoplastics In Crops: An Investigation Of 14C-Labelled Polystyrene Nanoplastic Into Radishes, Nathaniel J. Clark, Astrid C. Fischer, Demelza Carne, George R. Littlejohn, Lee J. Durndell, Anne Plessis, Richard C. Thompson

School of Biological and Marine Sciences

The capacity of crops to accumulate nanoplastics has remained relatively unexplored largely due to analytical constraints. To address this challenge, the present study employed a radiolabelling approach to demonstrate, for the first time, that polystyrene nanoplastics (¹⁴C-PS NPs) accumulate and move into the edible tissues of radishes (Raphanus sativus). Radishes were exposed hydroponically for five days, with only their non-fleshy roots in contact with the ¹⁴C-PS NPs, while accumulation in the fleshy (edible) roots and shoots was subsequently measured. The radish roots retained nearly 5 % of the ¹⁴C-PS NPs from the exposure, either through accumulation …

Characterizing Piezoelectric-Blended Polydimethylsiloxane For Use As A Mechanoelectrical Responsive Cell Culture Substrate, Alexis P. Applequist, Lance D. Cordes, Lais A. Ferreira, Kartik Balachandran

Biomedical Engineering Faculty Publications and Presentations

In this study, we developed a piezoelectric-polydimethylsiloxane (pz-PDMS) composite by blending poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)) with PDMS to create a biocompatible, mechanoelectrical responsive material. The pz-PDMS was synthesized with varying piezoelectric concentrations (0%, 1%, 3%, and 5%) and characterized for visual properties, mechanical properties, mechanoelectrical sensitivity, and biocompatibility. Compression testing showed no significant change in mechanical strength with the addition of piezoelectric particles, while mechanolectrical sensitivity testing revealed a non-linear increase in voltage response, with 5% pz-PDMS producing the highest sensitivity. Fatigue testing demonstrated no change in sensitivity after 7 days of cyclic displacement. Additionally, microcantilever experiments demonstrated the high fidelity …

Fabrication Of Multimodal Anion Exchange Membrane For Chromatographic Purification Of Full Adeno-Associated Viral Capsids, Xiaolei Hao, Sumith Ranil Wickramasinghe, Xianghong Qian

Biomedical Engineering Faculty Publications and Presentations

A multi-modal anion exchange ligand 2-methyl-phenylimidazole has been successfully functionalized on highly porous electrospun regenerated cellulose membrane substrate for the separation of full and empty adeno-associated viral (AAV) capsids. The functionalized membrane has an average pore size of 0.5 mu m and exhibits both charge and hydrophobic functionality. The ligand is able to distinguish the subtle physio-chemical differences between the full and empty viral capsids. The multi-modal anion exchange membrane is able to separate the full capsids from affinity-captured mammalian AAV2 using both gradient and two-step elution methods with superior performance. A full capsid recovery of 72.9% at 85.3% purity …

Cognitive Reserve Predicts Baseline Tau Burden In The Us Pointer Trial Imaging Cohort, Valory N Pavlik, Chris J Weber, Joseph C Masdeu, Laura D Baker, Melissa M Yu, Michele York, Rachel A Whitmer, Susan M Landau, Theresa M Harrison, Tomas M Holland, Laura Lovato

Faculty, Staff and Students Publications

Introduction: Higher cognitive reserve (CR) is associated with reduced dementia risk. We hypothesized that higher CR is associated with less baseline Alzheimer's disease (AD) pathology in the U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) cohort.

Methods: A subsample of participants underwent amyloid beta and tau positron emission tomography imaging. Regression analysis was used to model the association between educational attainment (EA) as a CR proxy measure, amyloid positivity, and entorhinal cortex (ERC) and meta-temporal region of interest (meta-ROI) tau standardized uptake value ratio (SUVR).

Results: In 911 participants with complete imaging data, higher …

Pathogenic Xpo1 Variants Cause A Dominant Neurodevelopmental Disorder, Amber S E Van Oirsouw, Pavla Nedbalova, Miroslava Hancarova, Jan Prchal, Darina Prchalova, Marketa Vlckova, Sarka Bendova, Kristin G Monaghan, Lisa M Dyer, Yanmin Chen, Deanna Alexis Carere, Emma A M Te Bogt, Heather Fisher, Angela E Scheuerle, Stephanie Riley, Mahim Jain, Weiyi Mu, Joann N Bodurtha, Albertien M Van Eerde, Marijn F Stokman, Nicola Longo, Meena Balasubramanian, Michael Spiller, Gregory Costain, Charlotte Von Der Lippe, Kristian Tveten, Marianne Jortveit, Øystein L Holla, Bertrand Isidor, Benjamin Cogné, Kevin E Glinton, Blake Vuocolo, Roberta Ann Sierra, Brad Angle, Kelly Bontempo, Klaas Koop, Rachel Rabin, John Pappas, David A Staffenberg, Pascal Joset, Peter Miny, Isabel Filges, Abdulrazak Alali, Kara Vitalone, Jill A Rosenfeld, Weimin Bi, Samuel Bradbrook, Renee Perrier, Subhadra Ramanathan, June-Anne Gold, María Palomares Bralo, María Ángeles Gómez-Cano, Ann Haskins Olney, Shelly Nielsen, Alban Ziegler, Dominique Bonneau, Clément Prouteau, Ange-Line Bruel, Charlotte Caille-Benigni, Laëtitia Lambert, Andrea C Yu, Nathaniel H Robin, Dana Goodloe, Jan Fischer, Joseph Porrmann, Yvonne D Hennig, Rami Abou Jamra, Isabella Herman, Ivy R Johnson, Lucas Hérissant, Guillaume Jouret, Koen L I Van Gassen, Ellen Van Binsbergen, Bert Van Der Zwaag, Alwin Kamermans, Renske Oegema, Zdenek Sedlacek, Michaela Fenckova, Richard H Van Jaarsveld

Faculty, Staff and Students Publications

Purpose: XPO1 functions in key cellular processes, including nucleo-cytoplasmic export and mitosis. The gene is deleted in a subset of patients with the 2p15p16.1 microdeletion syndrome; however, no monogenic XPO1-related disorder has been described to date.

Methods: We collected clinical data of individuals with de novo XPO1 variants through online matchmaking. We used Drosophila to study XPO1 function in development and habituation learning.

Results: A total of 22 individuals met the criteria to be included in the main study cohort. Of these, half have putative loss-of-function variants, and half have coding variants (10 missense and 1 in-frame deletion variant). We …

Glycerol-3-Phosphate Activates Chrebp, Fgf21 Transcription And Lipogenesis In Citrin Deficiency, Vinod Tiwari, Byungchang Jin, Olivia Sun, Edwin D J Lopez Gonzalez, Min-Hsuan Chen, Xiwei Wu, Hardik Shah, Andrew Zhang, Mark A Herman, Cassandra N Spracklen, Russell P Goodman, Charles Brenner

Faculty, Staff and Students Publications

Citrin deficiency (CD) is caused by the inactivation of SLC25A13, a mitochondrial membrane protein required to move electrons from cytosolic NADH to the mitochondrial matrix in hepatocytes. People with CD do not like sweets. Here we show that SLC25A13 loss causes the accumulation of glycerol-3-phosphate (G3P), which activates the carbohydrate response element-binding protein (ChREBP) to transcribe FGF21, which acts in the brain to restrain intake of sweets and alcohol and to transcribe key genes driving lipogenesis. Mouse and human data suggest that G3P-ChREBP is a mechanistic component of the Randle Cycle that contributes to metabolic-dysfunction-associated steatotic liver disease and forms …

Chemical Modulation Of Gut Bacterial Metabolism Induces Colanic Acid And Extends The Lifespan Of Nematode And Mammalian Hosts, Guo Hu, Marzia Savini, Matthew Brandon Cooke, Xin Wei, Dinghuan Deng, Shihong M Gao, Ruyue Alps Xia, Youchen Guan, Alice X Wen, Xin Yu, Jin Wang, Chao Jiang, Christophe Herman, Jiefu Li, Meng C Wang

Faculty, Staff and Students Publications

Microbiota-derived metabolites have emerged as key regulators of longevity. The metabolic activity of the gut microbiota, influenced by dietary components and ingested chemical compounds, profoundly impacts host fitness. While the benefits of dietary prebiotics are well-known, chemically targeting the gut microbiota to enhance host fitness remains largely unexplored. Here, we report a novel chemical approach to induce a pro-longevity bacterial metabolite in the host gut. We discovered that wild-type Escherichia coli strains overproduce colanic acids (CAs) when exposed to a low dose of cephaloridine, leading to an increased life span in the host organism Caenorhabditis elegans. In the mouse gut, …

Pleiotropy And The Increasing Complexity Of Parkinson's Disease Genetics, Jonggeol Kim, Joshua M Shulman

Faculty, Staff and Students Publications

No abstract provided.