Digital Commons Network^™

Porokeratosis Ptychotropica Mimicking A Herpes Simplex Virus Infection, Erin R. Pomerantz, Jayci G. Rhein, Jason B. Lee, Sylvia Hsu

Department of Dermatology and Cutaneous Biology Faculty Papers

Introduction

Porokeratosis encompasses a group of skin disorders characterized by abnormal keratinization, with the defining histologic feature of cornoid lamellae, which are stacks of parakeratotic cells that overlie dyskeratotic keratinocytes. Several subtypes of porokeratosis have been identified, including disseminated superficial actinic porokeratosis, porokeratosis of Mibelli, linear porokeratosis, porokeratosis palmaris et plantaris disseminata, punctate porokeratosis, and porokeratosis ptychotropica (PP).¹ Although risk factors for other forms of porokeratosis, such as UV exposure, immunosuppression, and genetic predisposition, have been identified, PP remains less understood. Clinically, PP typically presents as hyperkeratotic, verrucous plaques found bilaterally in the gluteal cleft and buttocks.^{2, …}

An Immunocompromised Patient With Cicatricial Alopecia, Dominique Revan, Victoria Stoj, Sherry Yang

Department of Dermatology and Cutaneous Biology Faculty Papers

Case description: A 37-year-old female with hemophagocytic lymphohistiocytosis presented with sudden onset hair loss that evolved over several hours during admission for neutropenic fever. Examination revealed a well-defined, tender, violaceous alopecic patch with intact follicular ostia (Fig 1). A punch biopsy showed ulcer with nonspecific changes. All fungal, bacterial, and mycobacterial stains were negative. During hospitalization, she was diagnosed with methicillin-resistant staphylococcus aureus (MRSA) bacteremia and discharged on intravenous daptomycin. She presented to the dermatology clinic 1 week later with worsening pain and hair loss, now with loss of follicular ostia.

Generative Ai And Empirical Software Engineering: A Paradigm Shift, Christoph Treude, Margaret-Anne Storey

Research Collection School Of Computing and Information Systems

The widespread adoption of generative AI in software engineering marks a paradigm shift, offering new opportunities to design and utilize software engineering tools while influencing both developers and the artifacts they create. Traditional empirical methods in software engineering, including quantitative, qualitative, and mixed-method approaches, are well established. However, this paradigm shift introduces novel data types and redefines many concepts in the software engineering process. The roles of developers, users, agents, and researchers increasingly overlap, blurring the distinctions between these social and technical actors within the field. This paper examines how integrating AI into software engineering challenges traditional research paradigms. It …

Comparative Analysis Of Autophagy And Apoptosis Pathways In Viral And Alcoholic Cirrhosis: An Immunohistochemical Study, Gunnur Demircan, Selimcan Berk, Doga Karayilan, Berkay T. Ozgur, Sema Ketenci, Ipek Elbegi, Vildan Karpuz, Melike Yavuz, Ahmet Midi, Demet Akin

Saudi Medical Journal

Objectives: To study the different cellular death mechanisms between viral cirrhosis and alcoholic cirrhosis. The research investigated autophagy and apoptosis mechanisms in hepatitis B virus (HBV), hepatitis C virus (HCV) and alcohol-induced cirrhosis. Methods: The research team analyzed biopsy samples from the liver which were obtained at Florence Nightingale Hospitals, Istanbul, Turkey. The experimental protocols were performed between February 2021 and February 2023. The study included 19 HBV, 15 HCV, 13 alcohol-related cirrhosis patients and 6 normal liver tissues. Beclin-1, Caspase-3, Bcl-2 and LC3 expressions were evaluated by immunohistochemistry. Results: Staining intensity as well as extent underwent evaluation through H-score …

The Relationship Of St6gal1 With Clinicopathological And Prognostic Factors In Breast Carcinomas, Ethem Ömeroğlu, Abdülhalim Serden Ay, Tuğba Günler, İlknur Küçükosmanoğlu, Sümeyye Kozacıoğlu

Saudi Medical Journal

Objectives: To investigate the association of β-galactoside α2-6 sialyltransferase 1 (ST6GAL1) expression with hormone receptor (HR), human epidermal growth factor receptor 2 (HER2), and other clinicopathological parameters, including histological grade, stage, lymphovascular invasion, perineural invasion, and survival in breast carcinomas (BCs). Methods: This study included 85 patients who had undergone surgery for breast cancer (BC). The associations of HR, HER2 status, and histopathologic tumor characteristics with immunohistochemical expression of ST6GAL1 were analyzed. Results: The majority (48 [56.5%]) of patients were in the T2 stage, and no association was seen between staging and ST6GAL1 ( p <0.05). Further, 44 (54.2%) patients were HR positive, and most of them exhibited high ST6GAL1 levels ( p =0.001), whereas 44 (51.8%) were HER2 negative, and most of them demonstrated low ST6GAL1 levels ( p =0.007). Ki-67 of ≥20% was observed in 55 (64.7%) and <20% in 30 (35.3%) patients. Most of those with high Ki-67 demonstrated low-grade STLGAL1 expression; however, no correlation was detected between the two values ( p =0.378). High and low ST6GAL1 expressions were observed in 39 (45.9%) and 46 (54.1%) cases, respectively. Conclusion: This research is one of the first studies to use ST6GAL1 in preoperative biopsies of patients not scheduled for neoadjuvant treatment. This study revealed highly significant associations of ST6GAL1 expression with HR, HER2, and molecular subtyping. Future studies are recommended to clarify the possible role of ST6GAL1 in resistance to HR and HER2-targeted and other chemotherapeutic agents in BCs.

Unusual Histopathologic Findings Of Appendectomy Specimens: A Retrospective Study Of Cases At Jordan University Hospital Over The Last Decade (2015-2024), Fatima N. Obeidat, Dina M. Nafi’, Anas N. Suleiman, Heb’A A. Al-Hyasat, Leen A. Alhadidi, Nada H. Budair, Omar J. Abushawer, Raya G. Al Kloub

Saudi Medical Journal

Objectives: To investigate the incidence and nature of unusual histopathological findings in appendectomy specimens and assess their impact on post-appendectomy management. Methods: A retrospective study was conducted on patients who underwent appendectomies at Jordan University Hospital between January 2015 and December 2024. It included patients with presumed diagnoses of acute appendicitis or those who underwent incidental appendectomies during other surgical procedures. Pathology reports with complete data and slides showing unusual findings were retrieved from the archives of the histopathology laboratory of the hospital. Statistical Package for the Social Sciences was used for statistical analysis. Results: Of the 2,275 patients, unusual …

Prognostic Significance Of The Borrmann Classification In Stage 2–3 Gastric Cancer, Selcan Cesur, Yonca Yılmaz Ürün

Saudi Medical Journal

Objectives: To assess the prognostic significance of Borrmann classification subtypes in patients with stage 2–3 gastric cancer who underwent surgical treatment. Methods: A retrospective review of 96 gastric cancer patients treated at Van Yüzüncü Yıl University Medical Faculty Hospital from 2008 to 2024 was conducted. Patients were included if they were aged >18 year (yr), had undergone surgery without neoadjuvant therapy, had no distant metastases, and had a postoperative pathological stage of 2-3. Demographic and clinicopathological data were documented, and median overall survival (OS) was analyzed according to the Borrmann classification. Results: The median age of the 96 patients was …

Autism Spectrum Disorder In Saudi Arabia: Clinical Dynamics From A Multi-Center Study, Sulhi A. Alfakeh, Ghaida H. Aljahdali, Sarah T. Benfeef

Saudi Medical Journal

Objectives: Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by impairments in communication, social interaction, and behavior. This study aimed to explore the factors influencing the clinical presentation of children with ASD in Saudi Arabia, focusing on demographic, medical, and environmental determinants. Methods: A multi-center, cross-sectional study was conducted in Saudi Arabia, enrolling 104 children diagnosed with ASD. Data were collected via structured parent interviews and analyzed to examine the relationships between demographic characteristics, therapy participation, self-care abilities, and clinical symptoms. Results: Male children were more likely to exhibit hyperactivity compared to females ( p =0.037). Age was significantly …

Can Blood Analyses In Dogs Provide Insights Into Human Aging?

Saudi Medical Journal

No abstract provided.

K–5 Teachers’ Perceptions Toward Implementing An Lgbtqia+-Inclusive Curriculum In New Jersey, Stephanie J. Faille

Walden Dissertations and Doctoral Studies

The problem that was addressed through this study is the gap in literature about K–5 teachers’ challenges in implementing an LGBTQIA+-inclusive curriculum in New Jersey. Grounded in Fuller’s concerns of teachers framework and Foucault’s seminal work on the historical treatment of members of the LGBTQIA+ community, the purpose of this basic qualitative study was to explore K–5 teachers’ challenges in implementing an LGBTQIA+-inclusive curriculum in New Jersey. Purposeful and snowball sampling were used to recruit 11 K–5 teachers who self-identified as having implemented the New Jersey LGBTQIA+-inclusive curriculum. Data collected through semistructured interviews were analyzed using a priori codes in …

Expanding Functionalities Of Immune Receptors Through Simultaneous Transfer Of Sensor And Helper Nlrs, Dongjiao Wang, Qibin Wu, Daowen Wang, Youxiong Que, Zheng Qing Fu

Faculty Publications

No abstract provided.

Enhancement Of Antimicrobial Activity Of Truncated Cecropin B Peptides With The Substitution Of Tryptophan Residues, Sarah Smith, Christopher Feudale, Josephina R. Vermillion, Joseph Feudale, Joshua Do, Sabrina Arroyo, Juan Barrera, Madeleine Whitsitt, Marion Duval, Colby Grames, Bret Hatzinger, Makenzie Hilling, Tia Kean, Jasayle Rivera, Mia Shum, Hannah Zyra, David Rovnyak, Moria C. Chambers

Faculty Journal Articles

Cecropins are a class of antimicrobial peptides (AMPs) expressed by insects that have broad-spectrum antimicrobial activity and low cytotoxicity. However, cecropins are also long (40–45 amino acids) peptides, making their adaptation for therapeutic use challenging. Here, we present a series of 16 amino acid-long peptides derived from cecropin B from Drosophila melanogaster. The native truncated peptide is cationic and expected to form an amphipathic α-helix, but does not have antimicrobial activity. The incorporation of two Trp residues, depending on the position in the peptide backbone, results in antibacterial activity compa-rable to that of full-length cecropin B against the gram-negative bacteria …

The Battle Over Water Fluoridation Comes To New York City: Organized Dentistry Is Quick To Respond To Ill-Conceived Effort To End 60-Year Practice And Vows To Stay With It Until The Threat Passes., Lance Plunkett Jd, Llm

The New York State Dental Journal

Water fluoridation has been experiencing its woes lately, beset by an adverse court decision, questionable science, collapsing federal public health priorities and public suspicion often fueled by hysteria. Against all this, New York City stood strong as a pioneering large municipality safely fluoridating its water since 1965 for the benefit of the public and reducing dental caries significantly over decades.

On Neutrohyperrings And Neutroorderedhyperrings, Fakhry Asad Agusfrianto, Saba Al-Kaseasbeh, Mariam Hariri, Yudi Mahatma

Neutrosophic Sets and Systems

The notion of Neutrosophic sets first introduced by Smarandache in 1998 as a generalization of intu itionistic fuzzy sets. Furthermore, Al-Tahan in 2022 introduced the notion of NeutroHyperstructures. Inspired by this research, in this study, we extend NeutroAlgebra and NeutroOrderedAlgebra by introducing two new concepts: NeutroHyperring and NeutroOrderedHyperring. These new concepts enrich the existing framework by incorporating neutrosophic elements, enabling the exploration of complex relationships and uncertainties within algebraic and ordered structures. Furthermore, NeutroHyperring applications on the NeutroRing is also introduced.

Short Note Of Supertree-Width And N-Superhypertree-Width, Takaaki Fujita

Neutrosophic Sets and Systems

This paper investigates the properties of tree-width and related graph width parameters for n SuperHyperGraphs, a broader generalization of hypergraphs. By exploring concepts such as SuperHyperTree width and Hypertree-width, we aim to understand how these structures resemble tree-like formations. We also analyze the relevance of these width parameters in computational contexts, following extensive research in graph theory and hypergraph applications

A Comprehensive Discussion On Fuzzy Hypersoft Expert, Superhypersoft, And Indetermsoft Graphs, Takaaki Fujita

Neutrosophic Sets and Systems

Graph theory, a branch of mathematics, studies relationships among entities through vertices and edges. To capture the inherent uncertainties in real-world networks, Uncertain Graph Theory has evolved within this field. Soft Expert Graphs combine conventional graph theory with expert assessments, using fuzzy sets for vertices and edges, while allowing expert opinions to shape the uncertainties and relationships within the graph. Hypersoft Graphs extend this concept further by incorporating multi-attribute nodes that represent multiple distinct attribute values, enabling the modeling of more complex, multi-dimensional relationships. In this paper, we define the Hypersoft Expert Graph and explore its connections to other classes …

An Overview Of Neutrosophic Graphs, Nihar Ranjan Panda, Prasanta Kumar Raut, Amarendra Baral, Srikanta Kumar Sahoo, Sakya Singh Satapathy, Said Broumi

Neutrosophic Sets and Systems

A new area of study called "neutrosophic graph theory" uses neutrosophic logic to expand on traditional graph theory to include ambiguous, indeterminate, and uncertain information. This paper gives a thorough introduction to neutrosophic graphs, including their definition, components, uses, and difficulties. Neutrosophic graphs let you show and analyze relationships that aren't clear-cut because they give vertices and edges different levels of truth, indeterminacy, and falsity. Image processing, social network analysis, pattern recognition, and decision-making in the face of uncertainty all use neutrosophic graphs. However, we still need to resolve issues like interpretability and computational complexity. All things considered, neutrosophic graphs …

Neutrosophic Sets And Systems, Vol. 77, 2025, Florentin Smarandache, Mohamed Abdel-Basset, Maikel Leyva-Vázquez

Neutrosophic Sets and Systems

the whole volume of 77

A Certain Algebraic Structure Of Bipolar Single Value Neutrosophic Subgroups And Its Essential Properties, Yousef Al-Qudah, Abdullah Alsoboh, Eman Hussein, Faisal Al-Sharqi, Abdullrahman A. Al Maqbali

Neutrosophic Sets and Systems

No abstract provided.

A Probabilistic Plithogenic Neutrosophic Rough Set For Uncertainty-Aware Food Safety Analysis, Ruixuan Chen, Qun Liu, Yucang Zhang, Wuyin Weng

Neutrosophic Sets and Systems

No abstract provided.

Mr-Metric Spaces: Theory And Applications In Fractional Calculus And Fixed-Point Theorems, Abed Al-Rahman M.Malkawi, Ayat M. Rabaiah

Neutrosophic Sets and Systems

No abstract provided.

Real-World Impact Of Amiodarone On Apixaban Population Pharmacokinetics In Hospitalized Patients, Samantha Kolowrat, Chazmyn Riley, Kevin Lam, Lynda Thomson, Douglas F. Stickle, Walter K. Kraft

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Despite common coadministration in nonvalvular atrial fibrillation (NVAF), there is minimal evidence regarding the impact of concomitant amiodarone use on apixaban pharmacokinetics (PK). We described the population PK of apixaban (2.5 and 5mg twice daily) in 106 hospitalized patients with and without concomitant amiodarone administration at steady state. Apixaban PK was reasonably described by a one-compartment model with first-order absorption and linear elimination. Aside from the receipt of amiodarone, age was retained as a statistically significant covariate on apparent clearance. Model-based simulations depicted concomitant amiodarone use increasing AUCT for both 2.5mg (1.58, 90% CI [1.28, 1.87]) and 5mg (1.12, 90% …

Comparison Of Model-Predicted And Observed Evinacumab Pharmacokinetics And Efficacy In Children Aged < 5 Years With Homozygous Familial Hypercholesterolemia., Sébastien Bihorel, Robert Dingman, Jeanne Mendell, Katy C. Norman, Richard T. George, Xue-Qiao Zhao, Robert Pordy, Daniel Garcia, Wendy S. Putnam, Geetha Raghuveer, Brian W. Mccrindle, Elena Fornari, Ivo Baric, Shubha Srinivasan, Melissa Diamond, Eliot A. Brinton, John D. Davis, A Thomas Dicioccio, Lutz Harnisch

Manuscripts, Articles, Book Chapters and Other Papers

Evinacumab, an angiopoietin-like 3 inhibitor, significantly reduces low-density lipoprotein cholesterol (LDL-C) in patients with homozygous familial hypercholesterolemia (HoFH). Herein, we report pharmacokinetic and efficacy analyses of evinacumab in <  5-year-old patients with HoFH. Population pharmacometric models characterizing evinacumab exposure and LDL-C response accounting for lipoprotein apheresis effect in ≥ 5-year-old patients were adapted for growth and maturation to predict and compare evinacumab and LDL-C concentrations across age/weight groups in virtual ≥ 6-month-old patients receiving 15 mg/kg evinacumab intravenous (iv) infusions every 4 weeks (q4w). As expected from allometric theory, weight-based dosing resulted in decreasing evinacumab exposures with declining body weight. Consistent with trends observed in > 5-year-old patients, the predicted percent change from LDL-C baseline (%∆LDL-C) was generally comparable or even higher in <  5-year-old patients (63.0%-68.5%) than in 5- to <  18-year-old patients (61.3%-67.8%) or adults (51.7%), with the predicted percentages of patients achieving %∆LDL-C > 50% also higher in <  5-year-old patients (82.0%-86.9%) versus 5- to <  18-year-old patients (72.0%-84.5%) and adults (54.8%). Through a managed access program, six 1- to <  5-year-old patients received between 5 and 23 iv infusions of 15 mg/kg evinacumab q4w. Rapid and clinically meaningful LDL-C reductions were observed, with %∆LDL-C at the last reported dose ranging from 41.3% to 77.3%. Based on the actual patient dosing and plasmapheresis history, model-predicted evinacumab and LDL-C concentrations were comparable to the observed data collected in the managed access program. Overall, this analysis provides evidence for the use of evinacumab 15 mg/kg iv q4w dosing regimen in 6-month-old to 5-year-old patients.

Concerns Regarding The Standard Deviation Of Individual Responses For Assessing Treatment Response Heterogeneity, Aaron R Caldwell, David B Allison, Andrew W Brown, Gary L Gadbury, Thirupathi Reddy Mokalla, R Drew Sayer, Andrew D Vigotsky

Children’s Nutrition Research Center Staff Publications

The estimation of treatment response heterogeneity (TRH) is increasingly important as medicine moves toward personalized approaches. While various statistical methods have been proposed to quantify TRH in parallel-group trials, the standard deviation of individual responses (SDIR) has gained prominence within physiological research. This method is intended to quantify individual response variation by comparing standard deviations of change scores between intervention and control groups. We acknowledge that SDIR represents an improvement over many other flawed approaches that often involve responder counting. However, SDIR has critical limitations: 1) it cannot overcome the fundamental problem of causal inference because the correlation between potential …

Restricting Metabolic Plasticity Enhances Stress Adaptation Through The Modulation Of Pdh And Hif1a In Trap1-Depleted Colon Cancer, Hong-Yuan Tsai, Miao-Hsueh Chen, Jihye Yun, Lisa A Lai, John F Valentine, Mary P Bronner, Teresa A Brentnall, Sheng Pan, Ru Chen

Faculty, Staff and Student Publications

Metabolic plasticity allows cancer cells to survive under adverse conditions. To investigate the role of mitochondrial chaperone tumor necrosis factor receptor-associated protein 1 (TRAP1) in this process, we used CRISPR/Cas9 mediated genetic deletion to knock out (KO) TRAP1 in colon cancer cells. Depletion of TRAP1 triggered a series of events: induced metabolic reprogramming, increased glycolytic flux, downregulation of mitochondrial complex I, and elevated ROS generation. TRAP1-deficient cells showed tolerance to Oxidative Phosphorylation (OXPHOS) inhibitors and exhibited a higher extracellular acidification rate (ECAR). Additionally, TRAP1 depletion activated hypoxia response elements (HREs) and upregulated HIF1A target genes such as GLUT1 and MCT1. …

Corporeal Property And The Limits Of Nagpra, M. Alexander Pearl

Fordham Law Review

No abstract provided.

Characterization And Antibacterial Properties Of Centrifugally Spun Polyvinylpyrrolidone/Copper(Ii) Acetate Composite Fibers, Batool Ibrahim, Roberto Curiel, Sara Ibrahim, Luis A. Materon, Oleg Ermolinsky, Helia Magali Morales, Jason Parsons, Mataz Alcoutlabi

School of Integrative Biological & Chemical Sciences Faculty Publications

The demand for effective antibacterial materials is growing rapidly in today’s world. Both metallic and metal oxide nanoparticles have been widely used as antibacterial agents against various bacterial species due to their unique mechanisms of destroying bacterial membrane cells. The current study explores the antibacterial activity of centrifugally spun fibers prepared from copper acetate polyvinylpyrrolidone (PVP) ethanol precursor solutions against both Gram-negative and Gram-positive bacteria. During the synthesis of the composite fibers, the physical and chemical conditions were optimized. The structure and morphology of the PVP/Cu-Ac fibers were analyzed using scanning electron microscopy (SEM), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy …

Assessing The Tumor Suppressive Impact And Regulatory Mechanisms Of Spdef Expression In Breast Cancer, Maansi Solanky, Maninder Khosla, Suresh K. Alahari

School of Graduate Studies Faculty Publications

Background/Objectives: Breast cancer is a heterogeneous disease, and the role of the transcription factor SPDEF remains controversial. We aimed to clarify the prognostic value of SPDEF, explore demographic and molecular correlates of its expression, and investigate potential regulatory mechanisms underlying its dysregulation. Methods: Genomic and clinical data for 1218 breast cancer tumors were obtained from The Cancer Genome Atlas (TCGA). SPDEF mRNA expression was compared across intrinsic subtypes, age, and race, and prognostic significance was evaluated by Kaplan–Meier analysis. Promoter methylation patterns and DNA methyltransferase (DNMT) expression were examined as potential regulatory drivers. Co-expression analysis was performed using gene panels …

An Efficient Self-Supervised Learning Framework For Swarm Robot Trajectory Analysis, Brooklyn Berry, Gaukhar Nurbek, Juan Manuel Perez, Richard Tapia, Qi Lu, Yifeng Gao

Computer Science Faculty Publications

Swarm robotics leverages groups of autonomous robots to perform complex tasks collaboratively. Recently, there has been growing interest in the Self-Supervised Learning framework (SSL) for social robots, yet very little research has been done on designing a SSL framework for foraging swarm robots systems. In this paper, to address the two challenges above, we proposed a novel efficient self-supervised learning framework. Specifically, we proposed 1) a shared weight multi-instance based encoder-decoder structure for model pre-training; and 2) an embedding series compression strategy to reduce the space cost in inference stage. Experiments show our system can match the performance of standard …

Data As Policy, Janet Freilich, W. Nicholson Price Ii

Faculty Scholarship

A large literature on regulation highlights the many different methods of policy-making: command-and-control rulemaking, informational disclosures, tort liability, taxes, and more. But the literature overlooks a powerful method to achieve policy objectives: data. The state can provide (or suppress) data as a regulatory tool to solve policy problems. For administrations with expansive views of government’s purpose, government-provided data can serve as infrastructure for innovation and push innovation in socially desirable directions; for administrations with deregulatory ambitions, suppressing or choosing not to collect data can reduce regulatory power or serve as a back-door mechanism to subvert statutory or common law rules. …