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Ilang Retrospektibo At Pagpapalawig Sa Kaisipang Reyes Hinggil Sa Aralín At Pagtuturo Ng Kulturang Popular Ngayon, Louie Jon A. Sánchez

Perspectives in the Arts and Humanities Asia

Layon ng sanaysay na ito na maghain ng retrospektibo o, wika nga ni Soledad S. Reyes, “balik-tanaw” sa dalawa niyang sanaysay na matatagpuang pampinid sa Pagbasa ng Panitikan at Kulturang Popular: Piling Sanaysay, 1976–1996 (1997) at sa pinatnugutan niyang teksbuk na Katha (1992) para sa Pamantasang Ateneo de Manila noong dekada 1990. Ang mga ito ay mahalagang pagtatala at pagninilay ng pangunahing iskolar ng kulturang popular sa Filipinas hinggil sa kaniyang mga kaisipan sa aralín at pagtuturo ng kulturang popular. Sa mga akda ring nabanggit, pinahahalagahan niya ang animasyon ng saliksik hinggil sa kulturang popular sa pedagohiya o pagkasangkapan sa …

Volume 13, Number 1, 2023, Volume 13, Number 1, 2023

Perspectives in the Arts and Humanities Asia

No abstract provided.

Rapid Epigenetic Response To Salinity Stress In An Invasive Mussel, Mytilus Galloprovincialis, Andrzej Furman, Açelya Eren, İbrahi̇m Raşi̇t Bi̇lgi̇n, Hati̇ce Aygün Karaçay

Turkish Journal of Zoology

The Mediterranean blue mussel (Mytilus galloprovincialis) is a well-known invasive species recognized for its remarkable ability to tolerate a wide range of environmental conditions. Here, we investigated DNA methylation changes in M. galloprovincialis exposed to a rapid water salinity decrease. Methylation profiles in M. galloprovincialis were recorded before salinity stress was applied (at 35‰), and then at 3, 9 and 24 h following the stress (at 25‰). We monitored these changes using the methylation-sensitive amplification polymorphism (MSAP) method. Methylation levels continued to vary over the 24 h period following stress exposure, indicating that the underlying physiological processes may have changed …

Phylogenetics Of Cyrtodactylus In West Nusa Tenggara: A New Distribution Record Of Cyrtodactylus Jatnai From Lombok Island And A Cryptic Species From Sumbawa Island, Sandra Rafika Devi, Rury Eprilurahman, Tuty Arisuryanti, Yuliadi Zamroni, Imran Sadewo, Windi Edriyanti, Maulana Faiz Ilham Kholiq, Evelyn Elvira

Turkish Journal of Zoology

Cyrtodactylus is one of the most diverse vertebrates of the Gekkonidae family, first described by Gray in 1827 and widely distributed in Asia, Northern Australia, and the Pacific Islands including Wallacea. The biodiversity in West Nusa Tenggara—a region in Wallacea—has been underestimated despite high fauna endemicity. Conservation strategies are needed to maintain the stability of Cyrtodactylus populations in their habitat. Therefore, this study aims to enhance the understanding of cryptic species and potential new distribution records of the genus Cyrtodactylus in West Nusa Tenggara. Molecular character identification was carried out by isolating the ND2 gene in liver tissue using polymerase …

Exploring The Experiences Of Bahamian Men Diagnosed With Hypertension And Medication Adherence, Bianca Edwards

Walden Dissertations and Doctoral Studies

Hypertension (HTN) is associated with significant health complications, including stroke, myocardial infarction, heart failure, and kidney disease. Despite advances in the treatment and management of HTN, a lack of medication adherence contributes to the persistence of HTN-related morbidity and mortality affecting men in The Bahamas. The purpose of this qualitative descriptive phenomenological study, guided by Pender’s health promotion model and Bandura’s social cognitive theory, was to explore the lived experiences of Bahamian men diagnosed with hypertension regarding their adherence to prescribed medications. Using Giorgi’s descriptive phenomenological method, in-depth, semistructured interviews were conducted with 11 participants. Data were analyzed through repeated …

The Impact Of Machine Learning Security Models On Cloud Data Security, Ali Sanad

Walden Dissertations and Doctoral Studies

Abstract Many information technology (IT) leaders face challenges in adopting machine learning (ML) models for cloud infrastructure, despite their potential to enhance data security. The extent to which IT leaders’ perceived security (PeS) and perceived privacy (PeP) influence their intent to adopt ML security models is critical for organizational success. Grounded in the technology acceptance model, the purpose of this quantitative correlational study was to examine the relationship between IT leaders’ PeS and PeP and their intent to adopt ML security models in cloud-based applications. Data were collected from 106 IT professionals in Chicago using a validated instrument. Results from …

Dating In The Digital Age: The Effects Of Parental Rejection, Rejection Sensitivity, And Self-Esteem Among Gender-Diverse Gen Z, Crystal Currie

Walden Dissertations and Doctoral Studies

Gen Z, the first digital-native cohort, faces unique challenges in forming romantic relationships, including heightened dating anxiety. While there is extensive research with previous generations on dating anxiety, self-esteem, and early rejection, no study has examined parental rejection, self-esteem, and dating anxiety collectively, particularly in consideration of gender diverse individuals and digital dating platform use. The purpose of this correlational study was to examine (a) predictors of dating anxiety and (b) whether parental rejection during childhood and rejection sensitivity influenced dating anxiety, as well as the role of self-esteem in mediating those predictor variables. The conceptual framework was the interpersonal …

Hemolysis Detection Using The Gem 7000 At The Point Of Care In A Pediatric Hospital Setting: Does It Affect Outcomes?, Ridwan B Ibrahim, Nazmin Bithi, Charlene Hernandez, Hanna Uhrova, Brandy D Recio, Sridevi Devaraj

Faculty, Staff and Students Publications

No abstract provided.

Advances In Artificial Intelligence For Glioblastoma Radiotherapy Planning And Treatment, Reid Master, Nesha Rubin, James Sampson, Kamlesh K Yadav, Shruti Pandita, Aria Sabbagh, Anika Krishnan, Patrick J Silva, Kenneth S Ramos, Vincent Gregoire, Nikos Paragios, Sunil Krishnan, Tej K Pandita

The Brown Foundation: Institute of Molecular Medicine

Glioblastoma is an aggressive central nervous system tumor characterized by diffuse infiltration. Despite substantial advances in oncology, survival outcomes have shown little improvement over the past three decades. Radiotherapy remains a cornerstone of treatment; however, it faces several challenges, including considerable inter-observer variability in clinical target volume delineation, dose constraints associated with adjacent organs at risk, and the persistently poor prognosis of affected patients. Recent advances in artificial intelligence, particularly deep learning, have shown promise in automating radiation therapy mapping to improve consistency, accuracy, and efficiency. This narrative review explores current auto segmentation frameworks, dose mapping, and biologically informed radiotherapy …

An Analysis Of Diagnostic Metabolomic Profiles Associated With Hepatotoxicity During Childhood All Induction Therapy, Emily J Mason, Anna M Crain, Michael E Scheurer, Philip J Lupo, Karen R Rabin, Olga A Taylor, Marley Roberts, John P Woodhouse, Ashley Chavana, Kathleen Ludwig, Laura Klesse, Kenneth Heym, Timothy Griffin, Rodrigo Erana, Juan Carlos Bernini, M Monica Gramatges, Joanna S Yi, Sandi L Pruitt, M Brooke Bernhardt, Hong Zhu, Steven D Mittelman, Van Huynh, Etan Orgel, Jeremy M Schraw, Austin L Brown

Faculty, Staff and Students Publications

Hepatotoxicity is a well-documented complication of induction chemotherapy for acute lymphoblastic leukemia (ALL), but our understanding of its biological mechanisms is limited. We identified 314 patients with ALL (aged 1-19 years) treated at Texas Children’s Hospital (2008-2019) with diagnostic bone marrow plasma available for metabolomic profiling: 234 for discovery and 80 for replication. Hepatotoxicity during induction was defined as follows: (1) transaminitis: grade ≥3 aspartate aminotransferase or alanine aminotransferase or (2) conjugated hyperbilirubinemia: conjugated bilirubin (c.bili) >3 mg/dL. Untargeted profiling detected 519 metabolites. Adjusted odds ratios (aORs) for each metabolite were calculated with logistic regression, accounting for sex, age, body …

Persistent Ifn-Γ Signaling In Acquired Resistance To Pd-(L)1 Blockade In Nsclc, Vasisht Karri, Samir Dalia

Student Publications

Immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) and programmed cell death ligand 1 (PD-L1) have transformed the therapeutic landscape of non-small cell lung cancer (NSCLC), producing durable responses in a subset of patients. Yet for most, clinical benefit is undermined by the development of acquired resistance (AR), a phenomenon that continues to limit the long-term success of immunotherapy. Recent analyses have drawn attention to persistent interferon-γ (IFN-γ) signaling as a paradoxical hallmark of AR: a cytokine typically associated with effective antitumor immunity that, when chronically engaged, sustains immune dysfunction. In this commentary, we synthesize existing literature to …

Stra8 Links Neuronal Activity To Inhibitory Circuit Protection In The Adult Mouse Brain., Ming Huang, Shuwen Yue, Xiaoyu Zhang, Lan Wu, Jay L. Vivian, Zi-Jun Wang, Ning Wang

Manuscripts, Articles, Book Chapters and Other Papers

While neuronal activity is essential for brain function, it also poses threats to neuronal integrity. Here, we show that activity-induced expression of stimulated by retinoic acid gene 8 (Stra8) protects neurons from degeneration. Previously considered germline specific, Stra8 is expressed in the adult mouse brain and is induced by neuronal activity via calcium influx and N-methyl-D-aspartate (NMDA) receptor signaling. Neuron-specific Stra8 knockout mice display hallmark features of neurodegeneration, including DNA damage, impaired proteostasis, inflammation, nuclear envelope erosion, reduced dendritic plasticity, memory deficits, and heightened excitotoxic vulnerability. Electrophysiological studies reveal disrupted inhibitory circuit function. Mechanistically, Stra8 binds regulatory regions of neuromodulator …

Nivolumab Plus Ipilimumab Induce Hyper-Progression In Renal Medullary Carcinoma: Results Of A Phase Ii Trial And Preclinical Evidence, Melinda Soeung, Xinmiao Yan, Ciro Zanca, Jing Qian, Menuka Karki, Fei Duan, Hania Khan, Li Zhang, David H Peng, Mariah Williams, Rong He, Ziheng Chen, Luigi Perelli, Jianfeng Chen, Rebecca S Tidwell, Pankaj K Chauhan, Courtney N Le, Truong N A Lam, Nirjar Bhattacharya, Rutvi Shah, I-Lin Ho, Jason P Gay, Caroline C Carrillo, Ningping Feng, Kang Le, Guang Gao, Teresa L Perry, Faika Mseeh, Yongying Jiang, Quanyun A Xu, Niki Marie Zacharias, Rahul A Sheth, Tharakeswara K Bathala, Priya Rao, Najat C Daw, Durga N Tripathi, Cheryl L Walker, Mohammad M Mohammad, Jianhua Zhang, Guangchun Han, Yanshuo Chu, Ruiping Wang, Minghao Dang, Enyu Dai, Fuduan Peng, Yunhe Liu, Akshaya Jadhav, Wenhua Lang, Claudio A Arrechedera, Leticia Campos Clemente, Edwin R Parra, Hsinyi Lu, Cara L Haymaker, Ignacio I Wistuba, Andrew Futreal, Andrea Viale, Michael J Soth, Philip Jones, Joseph R Marszalek, Timothy Heffernan, Giulio F Draetta, Nizar M Tannir, Jianjun Gao, Linghua Wang, Giannicola Genovese, Pavlos Msaouel

Faculty, Staff and Students Publications

Therapeutic options for patients with renal medullary carcinoma (RMC) are limited. Here we report the results of a phase II clinical trial (NCT03274258) of anti-PD1 nivolumab plus anti-CTLA4 ipilimumab in patients with RMC, with objective response rate as primary outcome. Enrollment was halted for futility at a prespecified interim analysis as all 10 treated patients experienced rapid disease progression. 5/10 met radiological criteria for hyperprogression and median progression-free survival (secondary outcome) was 1.38 months (95% confidence interval: 1.28, 1.60). In a post-hoc single-cell RNA sequencing analysis, data from patients with RMC before and after nivolumab plus ipilimumab treatment indicated that …

Leaping Between Branches: Hybridisation And The Tangled Evolutionary History Of True Lemurs, Giacomo Mercuri, Giovanni Merici, Kyle Kai-How Farh, Lukas F K Kuderna, Jeffrey Rogers, Tomàs Marques-Bonet, Giuseppe Donati, Riccardo Percudani, Cristian Capelli

Faculty, Staff and Students Publications

The true lemurs (genus Eulemur) are a genetically diverse and spatially widespread group of species inhabiting most of Madagascar's forests. Including 12 recognized species, the genus can be divided into four major evolutionary groups: E. rubriventer, E. mongoz, the Brown Lemur Species Complex (BLSC), and the coronatus-macaco-flavifrons complex (CMFC), although monophyly for the CMFC is not always supported. Recent genome-based studies highlighted topological and chronological differences between nuclear and mitochondrial phylogenies of true lemurs, which could be explained by events of hybridisation. In order to reconstruct the evolutionary history of the genus, we test for gene-flow between Eulemur clades using …

Turning Patients' Open-Ended Narratives Of Chronic Pain Into Quantitative Measures: Natural Language Processing Study, Raquel Norel, Jennifer Gewandter, Zhengwu Zhang, Anika Tahsin, Chadi G Abdallah, John Markman, Zhiyao Duan, Guillermo Cecchi, Paul Geha

Faculty, Staff and Students Publications

Background: Subjective report of pain remains the gold standard for assessing symptoms in patients with chronic pain and their response to analgesics. This subjectivity underscores the importance of understanding patients' personal narratives, as they offer an accurate representation of the illness experience.

Objective: In this pilot study involving 20 patients with chronic low back pain (CLBP), we applied emerging tools from natural language processing (NLP) to derive quantitative measures that captured patients' pain narratives.

Methods: Patients' narratives were collected during recorded semistructured interviews in which they spoke about their lives in general and their experiences with CLBP. Given that NLP …

Botulinum Toxin Combined With Robot-Assisted Therapy For Post-Stroke Spasticity: A Systematic Review, Salvatore Facciorusso, Stefania Spina, Mirko Filippetti, Rajiv Reebye, Gerard E Francisco, Andrea Santamato

Faculty, Staff and Student Publications

Background: Post-stroke spasticity limits motor recovery and independence. Combining botulinum toxin type-A (BoNT-A) injection with intensive, task-specific robot-assisted therapy (RAT) might enhance neuroplasticity and functional gains, but its additive effect and optimal timing are uncertain. (

Methods: We systematically searched major medical databases and trial registries up to April 2025 for randomized controlled trials in adults with post-stroke spasticity comparing botulinum toxin type-A injection plus RAT with toxin injection plus conventional therapy, or RAT alone with RAT combined with toxin injection. Risk of bias was assessed using the RoB 2 tool, and findings were synthesized narratively.

Results: Seven trials ( …

Identification Of Novel Tat-I24-Related Peptides With Antiviral Activities, Hanna Harant, Siegfried Hofinger, Reingard Grabherr, Zsolt Ruzsics, Hartmut Hengel

Michigan Tech Publications

To identify novel peptides with potential antiviral activities, a database search was performed based on the primary sequence of the peptide I24 (CLAFYACFC), the effective part of the antiviral peptide TAT-I24 consisting of peptide I24 and the cell penetrating TAT-peptide (amino-acids 48–60, GRKKRRQRRRPPQ). A Protein BLAST search identified several sequences with high similarity to I24 in diverse proteins, some of which are known to be involved in the interaction with nucleic acids. Selected sequences and newly designed variants of I24 were synthesized as TAT fusion peptides and tested for antiviral activity in two well-established models: baculovirus transduction of HEK293 cells …

Cover And Contents

Turkish Journal of Zoology

No abstract provided.

The Effects Of Montelukast Sodium On Some Biological And Biochemical Aspects, Dna Damage In Drosophila Melanogaster Adults, Ci̇hat Çeli̇k

Turkish Journal of Zoology

Montelukast sodium (MS) is a leukotriene receptor antagonist and used clinically as an antiasthma agent. MS has been hypothesized to have adverse effects in insects. To test this hypothesis, MS was added to the artificial diet of the fruit fly Drosophila melanogaster Meigen (Diptera: Drosophilidae) at different concentrations (1200, 1600, 2000, and 2400 mg/L) under laboratory conditions. The effects of MS on the survival rate and development time of D. melanogaster, as well as its effects on malondialdehyde (MDA) levels and cytochrome P450 monooxygenase (CYP450) enzyme activity in adults were investigated. The genotoxic effect of MS in whole adults was …

Ecotoxicological Assessment Of A Sunscreen-Derived Pollutant, Benzophenone-2, On Freshwater Fish (Labeo Rohita), Mina Jamil, Sajid Abdullah, Maham Riaz, Sana Aziz

Turkish Journal of Zoology

Ultraviolet filters (UVFs) are constituents of skincare products that protect skin against UV ray damage, such as suntan, sunburn, and skin tumors. Due to their ability to biotransform, UVFs are considered emerging pollutants. Benzophenone-2 (BP-2), with a yellowish crystalline appearance, is one of the widely used UVFs in skincare products. It enters the aquatic environment by washing off the skin during swimming and recreational activities and becomes hazardous to aquatic life due to its lipophilicity and bioaccumulative potential. This study was designed to evaluate the acute and chronic toxicity of BP-2 for the freshwater fish Labeo rohita. For acute toxicity, …

Bathyal Gastropod (Mollusca) Species From The Turkish Levantine And Aegean Seas, Bi̇lal Öztürk

Turkish Journal of Zoology

This study assigns 35 gastropod specimens and 23 shells collected from two sites on the Turkish Levantine and Aegean coasts at depths of 432 and 702 m, respectively, to 13 species. Among the species identified, Alvania subsoluta (Aradas, 1847), Protatlanta souleyeti (Smith, 1888), Pagodula echinata (Kiener, 1839), Pleurotomella gibbera Bouchet & Warén, 1980, Ringicula gianninii Nordsieck, 1974 and Diaphana marshalli (Sykes, 1904) are new records for the Turkish molluscan fauna; Anatoma aspera (Philippi, 1844) and Acteon monterosatoi Dautzenberg, 1889 are new records for the Levantine coast of Türkiye; and Crenilabium exile (Jeffreys, 1870) is a new record for the Turkish …

A Feature-Free Deep Learning Approach For Midair Hand Gesture Recognition From Surface Electromyogram (Semg) Data, Yasir Altaf, Abdul Wahid, Mudasir Manzoor Kirmani

Turkish Journal of Electrical Engineering and Computer Sciences

Midair hand gesture recognition plays a crucial role in applications such as sign language recognition and human-computer interaction, particularly for supporting individuals with partial or complete hearing loss. However, recognizing gestures in midair remains challenging due to the rapid and complex nature of hand movements. To address this, noninvasive techniques like surface electromyography (sEMG)—which captures muscle activity through sensors placed on the skin—have gained attention. sEMG provides rich time-series data that reflect both spatial and temporal muscle dynamics. In this study, we propose a deep learning architecture that combines convolutional neural networks (CNNs) and recurrent neural networks (RNNs) to classify …

Decision Support To Meet Objectives For Water And Fisheries Management In Large River And Estuarine Systems, Phaedra Elizabeth Budy

Funded Research Records

No abstract provided.

Prospective Sars-Cov-2 Additional Vaccination In Immunosuppressant-Treated Individuals With Autoimmune Diseases In A Randomized Controlled Trial, Meggan Mackay, Alfred Hj Kim, Et Al.

2020-Current year OA Pubs

BACKGROUND: Individuals with autoimmune diseases (AD) on immunosuppressants often have suboptimal responses to COVID-19 vaccine. We evaluated the efficacy and safety of additional COVID-19 vaccines in those treated with mycophenolate mofetil/mycophenolic acid (MMF/MPA), methotrexate (MTX), and B cell-depleting therapy (BCDT), including the impact of withholding MMF/MPA and MTX.

METHODS: In this open-label, multicenter, randomized trial, 22 participants taking MMF/MPA, 26 taking MTX, and 93 treated with BCDT who had suboptimal antibody responses to initial COVID-19 vaccines (2 doses of BNT162b2 or mRNA-1273 or 1 dose of AD26.COV2.S) received an additional homologous vaccine. Participants taking MMF/MPA and MTX were randomized (1:1) …

Mitochondrial Iron Transport Via Mfrn1 Is Required For Erythroid Cell Cycle Progression, Mark Perfetto, Aidan Danoff, Muhammad Ishfaq, Heidi Monroe, Aiden Mohideen, Meilin Chen, Jesus Tejero, Amber N Stratman, Satoshi Okawa, Yvette Y Yien

2020-Current year OA Pubs

Iron metabolism drives key erythropoietic processes, including hemoglobinization, survival, and proliferation. Here, we developed in vivo methods to interrogate how iron regulates erythropoiesis and report that mitochondrial iron transport via mitoferrin-1 (MFRN1) is essential for erythroid cell cycle progression. mfrn1 embryos had severely decreased erythroid cell number caused by cell cycle arrest at G2/M. They had enlarged nuclei, suggesting a mitotic defect. Iron supplementation rescued the cell cycle defect, implicating mitochondrial iron deficiency as its cause. In contrast, fpn1 mutants, anemic from systemic iron deficiency, had less severe decreases in erythroid mitochondrial iron than mfrn1 mutants and no proliferative defects. …

Bio-Corrosion Studies On Novel Zr‑Co‑Ti Based Metallic Glass Alloys For Biomedical Implant Applications, Shubhra Shitole

Thesis/ Dissertation Defenses

The relentless pursuit of advanced biomaterials that synergistically combine high mechanical strength, exceptional corrosion resistance, and inherent biocompatibility is critical for next-generation medical implants. This research addresses this challenge through the development and multi-faceted evaluation of a novel library of Zr-Co-Ti-based metallic glasses (MGs); Zr₆₀Co₃₀Ti₁₀, Zr₅₅Co₃₅Ti₁₀, and Zr₅₀Co₄₀Ti₁₀, fabricated via melt-spinning. The alloys were confirmed to be fully amorphous by X-ray diffraction (XRD), a structure underpinned by exceptional thermal stability, with the Zr60 composition exhibiting a larger supercooled liquid region (Δ𝑇𝑥) of …

Determination Of Steroid Hormones And ⍺-Zeranol In Beef Products In East Tennessee, W. Colby Huffman, S. Ellie Jaynes, Nathan C. Duncan, D. Andrew Crain

RURALS: Review of Undergraduate Research in Agricultural and Life Sciences

Hormone growth implants are commonly used in cattle to increase growth and there is some concern that these implants may result in altered hormone concentrations in the beef from implanted cattle. This study aims to (1) develop a simple, standard, cost-effective method to measure hormones in beef and (2) compare hormones in meat from cattle not exposed to growth implants (negative controls), cattle exposed to growth implants (positive controls), and from a commercial retail store. Extraction and measurement using LCMS/MS was successful in detecting 17b-estradiol, progesterone, testosterone, and a-zeranol in meat, with a trend to lower concentrations in meat not …

Immunological Surveillance Against Cancer Across Mammals, Orsolya Vincze, Piotr Minias, Alexandre Corthay, Fernando Colchero, Jean-François Lemaître, Louise Maille, Tamás Malkócs, Justus Hagemann, Dalia A. Conde, Samuel Pavard, Antoine M. Dujon, Beata Ujvari, Frédéric Thomas, Amy M. Boddy, Carlo C. Maley, Damien Chevallier, Tuul Sepp, Thomas Pradeu, Mathieu Giraudeau

Presidential Fellows Articles and Research

Contrary to expectations based on their higher cell numbers, larger and longer-lived species do not face dramatically increased risk of cancer. This strongly suggests that evolution has fashioned natural cancer resistance mechanisms, yet our knowledge remains limited on what these mechanisms might be. The cancer immunological surveillance hypothesis, proposed by Burnet and Thomas in the 1950s, highlights immunity as a key factor determining species-specific cancer resistance. Here we address the original, evolutionary interpretation of this hypothesis by investigating the relationship between cancer mortality risk and markers of efficient antigen presentation. Our results show that the expansion of the MHC class …

Dissecting The Efficacy And Immunogenicity Of Tlr7 Agonist–Antibody Conjugates Through The Lens Of Fc Effector Function, Conjugation Strategies, And Linker Cleavability, Siteng Fang, Samantha R. Benjamin, Lina Wu, Mohammad Asikur Rahman, Kayla K. Elder, Victor T. Ojo, Tao Zhang, Tracy A. Brooks, L. Nathan Tumey

Pharmacy Faculty Scholarship

The advent of immuno-oncology therapeutics has given rise to antibody-drug conjugates (ADC) designed to selectively activate pattern recognition receptors such as Toll-Like Receptors (TLRs). In contrast to classical ADC technology, these Immune Stimulating Antibody Conjugates (ISACs) are widely reported to rely on Fcγ-mediated uptake and noncleavable linkers. Herein, we systematically study the impact of Fc effector function, linker cleavability, and conjugation strategy on the efficacy and immunogenicity of a series of TLR7 agonist-based ISACs. We demonstrate that the combination of FcγR-ablation and incorporation of a cleavable linker results in increased stimulation of myeloid cells, enhanced efficacy, and improved tolerability as …

A Silver Spoon Effect Reduces Lifetime Fitness In A Declining Loon Population, Walter H. Piper, Claudia Kodsuntie, Hayden Walkush

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

A complete understanding of factors that influence animal fitness requires that we measure not only those occurring day to day in the life of an animal but also those that operate on longer time scales. Here, we investigated silver spoon effects (fitness impacts resulting from conditions faced early in life) and carryover effects (fitness impacts caused by environmental factors in a previous season) in a northern Wisconsin population of the common loon (Gavia immer). The mass of a loon chick divided by its age, an indication of food it received from its parents in its first 4 to …