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Potency Dependent Angiogenic Effect Of Bellis Perennis On In Ovo Chick Chorioallantoic Membrane Assay, Jayanthdevan V, Winston Vargheese V, Anish Fathima K, Lohita S

Indian Journal of Research in Homoeopathy

Background: Hormesis is the biological response of an organism for a particular dosage of a substance. The lower dose stimulates and higher dose inhibits. J Compton Burnett, an eminent homeopath, prescribed Bellis perennis for breast and uterine tumours, which suggests it could be due to the antiangiogenic property or angiogenic inhibiting property and clinically also it is used for healing of fractured bone and wound healing which may be due to angiogenic promoting property. This experiment deals with the dose dependent effect of Bellis perennis on In Ovo Chick Chorioallantoic Membrane Assay. Objective: To evaluate the Hormesis effect of Bellis …

Guiding Principles For Teaching About Genocide And Other Difficult Pasts, Kerry E. Whigham

Genocide Studies and Prevention: An International Journal

This article outlines guiding principles for teaching “difficult pasts”—episodes of large-scale, identity-based violence such as genocide, crimes against humanity, colonialism, and enslavement—in ways that promote peace, human rights, and the prevention of future atrocities. Drawing from the fields of Holocaust and Genocide Education (HGE), Global Citizenship Education (GCED), Peace Education (PE), and Human Rights Education (HRE), it argues that instruction should move beyond the memorization of historical facts toward developing students’ socio-emotional and behavioral capacities to recognize and resist processes of othering, discrimination, and violence. The brief presents three main areas of guidance: curricular content, emphasizing conceptual understanding over rote …

Isg15 Dysregulates Endoplasmic Reticulum-Mitochondrial Contacts And Calcium Homeostasis In Ataxia Telangiectasia, Oygul Mirzalieva, Ryan E. Reed, Arthur L. Haas, Meredith A. Juncker, Patrick Logarbo, Jennifer M. Klein, David Worthylake, Shyamal D. Desai

School of Graduate Studies Faculty Publications

Dysregulation of endoplasmic reticulum and mitochondrial (ER:Mit) contacts and mitochondrial calcium (mitCa2+) homeostasis are found in several neurodegenerative disorders, including Ataxia Telangiectasia (A-T). However, the cellular basis of these defects remains unclear. Previously, we demonstrated that the aberrantly elevated Interferon-Stimulated Gene 15 (ISG15) pathway inhibits protein polyubiquitylation, its dependent protein turnover, and mitophagy pathways in A-T. Literature indicates that silencing of mitochondrial ubiquitin ligase 1 (MUL1) stabilizes mitofusin2 (MFN2) and attenuates mitCa2+ uptake from ER to Mit (mitCa2+influx) in primary neurons. We have replicated these findings in apparently healthy fibroblasts. We hypothesized that elevated ISG15 may inhibit ubiquitin-dependent MUL1-mediated degradation …

A New Dioecious Bush Tomato, Solanum Nectarifolium (Solanaceae), From The Northern Tanami Desert, Northern Territory, Australia, With Reassessment Of S. Ossicruentum And A Change In The Circumscription Of S. Dioicum, Christopher T. Martine, Kym Brennan, Jason T. Cantley, Aiden Webb, Geoffrey Newton

Faculty Journal Articles

A new species of functionally dioecious bush tomato from the “Solanum dioicum + S. echinatum group” of Solanum subgenus Leptostemonum is described. Solanum nectarifolium Martine & Brennan, sp. nov., is a member of the taxonomically challenging Solanum dioicum W.Fitzg. species complex in Australia and differs from other species in the group by the presence of prominent and conspicuous extrafloral nectaries on the abaxial leaf surfaces, a tinge of purple on the new growth and young fruiting calyces, and curved prickles on young stems. Although fairly well represented in herbarium collections, this new taxon has historically been treated as a …

The Concise Guide To Pharmacology 2025/26: Catalytic Receptors, Stephen P. H. Alexander, Doriano Fabbro, Chloe J. Peach, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Annie Beuve, Peter Brouckaert, Clare Bryant, John C. Burnett, Richard W. Farndale, Andreas Friebe, John Garthwaite, Adrian J. Hobbs, Gavin E. Jarvis, Laura Kilpatrick, Doris Koesling, Michaela Kuhn, Birgit Leitinger, David Macewan, Tom P. Monie, Lincoln R. Potter, Michael Russwurm, Harald H. H. W. Schmidt, Johannes-Peter Stasch, Scott A. Waldman

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear, accessible, and well-structured, rather than the scope of the content, which spans approximately 500 pages. The Concise Guide summarises the key pharmacological properties of around 1900 human drug targets, and nearly 7000 interactions, involving around 4400 ligands. While the content is a substantially condensed version of …

Sex Differences In Bile Acid Homeostasis And Excretion Underlie The Disparity In Liver Cancer Incidence Between Males And Females, Megan E Patton, Sherwin Kelekar, Lauren J Taylor, Angela E Dean, Qianying Zuo, Rhishikesh N Thakare, Sung Hwan Lee, Emily C Gentry, Morgan Panitchpakdi, Pieter Dorrestein, Yazen Alnouti, Zeynep Madak-Erdogan, Ju-Seog Lee, Milton J Finegold, Sayeepriyadarshini Anakk

Faculty, Staff and Student Publications

Hepatocellular carcinoma (HCC), the common liver cancer, exhibits higher incidence in males. Here, we report that mice lacking bile acid (BA) regulators, Farnesoid X Receptor (FXR also termed NR1H4) and Small Heterodimer Partner (SHP also termed NR0B2), recapitulate the sex difference in liver cancer risk. Since few therapeutic options are available, we focused on understanding the intrinsic protection afforded to female livers. Transcriptomic analysis in control and NR1H4 and NR0B2 double knockout livers identified female-specific changes in metabolism, including amino acids, lipids, and steroids. To assess translational relevance, we examined if transcriptomic signatures obtained from this murine HCC model correlate …

Agentic Ai In 6g Wireless Security: Methods, Applications, And Challenges, Zekra Sakr, Mona Mohamed

Sustainable Machine Intelligence Journal

The move from 5G to 6G networks brings new opportunities but also major challenges, especially in security. Static machine learning and deep learning models are two examples of traditional AI techniques that frequently fail because they are unable to adequately adapt to rapidly evolving threats or provide a clear explanation for their choices. Agentic AI presents an achievable strategy to enhance the security, adaptability, and reliability of 6G systems through its capacity for perception, reasoning, and autonomous action. In this study, we present a comprehensive evaluation of 6G cybersecurity in relation to agentic AI. We evaluate current research, point out …

Patient And Systemic Barriers To Cancer Care: Implications For Delayed Prostate Cancer Detection In Tanzania, Jane Senga John

Tanzania Journal of Sociology

Prostate cancer is a leading cause of cancer-related mortality among men in Tanzania, with most cases diagnosed at advanced stages. This study explores the interplay of patient-level and systemic barriers that contribute to delayed prostate cancer detection within a tertiary hospital context. Conducted at Bugando Medical Centre in Mwanza, the research employed in-depth interviews with 25 purposefully selected participants, including patients, oncologists, spouses and traditional healers. Thematic analysis was used and guided by Paul Farmer’s structural violence model and Courtenay’s theory of gender and health to interpret how cultural, economic, and structural factors shape health-seeking behaviours. Findings reveal that delays …

Electrochemical Characterization And Modulation Of Biological Processes, Yue-Qi Li, Wei-Hua Huang, De-Chen Jiang, Bao-Hong Liu, Bin Su, Yang Tian, Jing-Juan Xu, Ping Yu, Feng Zhao, Huang-Xian Ju, Jing-Hong Li

Journal of Electrochemistry

Electrochemical processes lie at the core of biological function, governing energy transduction, metabolic flux, and molecular signaling. Recent advances in electrochemical science now allow these processes to be probed and controlled with unprecedented spatial, temporal, and chemical resolution. In this review, we present an integrated framework that progresses from fundamental mechanisms to analytical technologies and functional modulation. We begin by outlining electron transfer pathways in mitochondrial respiration, microbial extracellular electron transfer, and DNA- and protein-based charge conduction, followed by the principles of photon-electron conversion in photosynthesis and the central role of redox equilibrium in coordinating cellular responses. We then highlight …

Comparative Effects Of Gamma Irradiation And Chemical Treatments On Superficial Scald And Quality Of ‘Granny Smith’ Apples, Francisco E. Loayza, Michelle Tu, Hagop S. Atamian, Anuradha Prakash

Food Science Faculty Articles and Research

Fresh produce is highly perishable, necessitating various postharvest treatments to minimize quality loss, extend shelf-life, and facilitate international trade. This study investigated the potential of a single low-dose gamma irradiation treatment as an alternative to commercially used chemical treatments for protecting ‘Granny Smith’ apples against insect pests and postharvest disorders. ‘Granny Smith’ apples harvested in 2019 and 2020 were treated with gamma irradiation at doses of 240 or 860 Gray (Gy) or with commercial chemical applications of 1-methylcyclopropene (1-MCP), diphenylamine (DPA), or methyl bromide (MeBr). The impact on fruit quality, physiology, and the development of postharvest disorders was evaluated after …

Pressure Field Estimation From 2d-Piv Measurements: A Case Study Of Fish Suction-Feeding, Jensine C. Coggin, Duvall Dickerson-Evans, Erin E. Hackett, Roi Gurka

Physics and Engineering Science

Particle image velocimetry (PIV) flow measurements are common practice in laboratory settings in a wide variety of fields involving fluid dynamics, including biology, physics, engineering, and medicine. Dynamic fluid pressure is a notoriously difficult property to measure non-intrusively, yet its variation is a driving flow force and critical to model correctly. Techniques have been developed to estimate the pressure from velocity and velocity gradient measurements. Here, we highlight a novel application of boundary conditions when applying such pressure estimation techniques based on two-dimensional PIV data; the novel method is especially relevant to problems with complex boundary conditions. As such, it …

Comprehensive Mechatronic Design Methodology For 6-Dof Stationary Lower Limb Rehabilitation Exoskeleton Robot With Safety-Integrated Control Architecture, Javlonbek Rakhmatillaev Mr., Nodirbek Kimsanboyev Mr., Umidjon Takabaev Mr., Zafar Juraev3 Dr.

Chemical Technology, Control and Management

This paper presents the mechatronic design of a proposed six-degree-of-freedom (6-DOF) stationary lower limb rehabilitation exoskeleton (SLLRE) robot, developed through a comprehensive mechatronic design methodology that includes mechanical design, actuator and sensor selection, and the development of a control structure based on a safety-oriented control approach. The proposed 6-DOF SLLRE mechanical design introduces a comprehensive mechanical structure comprising bilateral hip, knee, and ankle joints, degrees of freedom, joint ranges of motion, human parameters for rehabilitation training, as well as the frames and structural elements of the proposed system. Furthermore, the selection of appropriate sensors, actuators, and control architecture for the …

Radiographic Assessment Of Anterior Maxillary Sites Prior To Immediate Implant Placement: A Retrospective Study On Cbct, Elissa El Alam, Abdallah Menhall, Nabil Ghosn, Pierre Lahoud

International Arab Journal of Dentistry

Objectives: The purpose of this retrospective radiographic study was to measure alveolar bone width at the alveolar crest, intraosseous root length, apical bucco-palatal bone thickness and apical bone height at the anterior maxillary teeth prior to immediate implant placement. Dehiscence and fenestration at these sites were also reported.

Methods: 50 CBCTs were included in this study. Measurements were taken on the right and left sides of the central incisor, lateral incisor, and canine using a 3d slicer program. Frequency of fenestration and dehiscence at these sites were also reported.

Results: Mean bone width at the alveolar crest of the central …

Effect Of Different Deep Margin Elevation Thicknesses Versus No Elevation On The Fracture Resistance Of Indirect Restorations: An In-Vitro Study, Fleurene Daraze, Karim Corbani, Brigitte Douaihy, Hadi Jomaah, Cynthia Kassis

International Arab Journal of Dentistry

Objectives: This in-vitro study aimed to evaluate whether different deep margin elevation (DME) thicknesses (1 mm, 2 mm, 3 mm) influence the fracture resistance and fracture type of molars restored with CAD/CAM lithium disilicate overlays, compared to no elevation.

Methods: Seventy-six extracted human molars were randomly divided into four groups (n=19) based on Deep Margin Elevation thickness: 0 mm (control), 1 mm, 2 mm, and 3 mm. Standardized Class II cavities were prepared with cervical margins extending 1 mm below the cementoenamel junction. DME was performed using a low-viscosity hybrid composite. Using a CAD/CAM workflow, overlays were designed and milled …

A Comprehensive Analysis Of The Accurate Diagnosis Of Chronic Non-Bacterial Osteomyelitis Of The Jaw In Young Patients: An Assessment Of Clinical And Laboratory Data, Alexander Yu Kugushev, Andrey V. Lopatin, Suzan Dagher

International Arab Journal of Dentistry

Objectives: Chronic non-bacterial osteomyelitis (CNO) is a rare autoinflammatory bone disorder predominantly affecting pediatric and adolescent populations. The clinical presentation is heterogeneous, with persistent pain and swelling representing the most frequent and often initial symptoms. These manifestations are commonly localized to the mandible, although involvement of other skeletal sites, including long bones, clavicle, and vertebrae, may occur in more advanced cases. Beyond localized symptoms, some patients exhibit mild systemic features such as low-grade fever, fatigue, or malaise; however, these systemic signs are generally less pronounced than those observed in infectious osteomyelitis. The diagnostic evaluation of CNO is intricate and necessitates …

Role Of Gut Microbiome In Oncogenesis And Oncotherapies, Renuka Sri Sai Peddireddi, Sai Kiran Kuchana, Rohith Kode, Saketh Khammammettu, Aishwarya Koppanatham, Supriya Mattigiri, Harshavardhan Gobburi, Suresh K. Alahari

School of Graduate Studies Faculty Publications

The gut microbiome has emerged as a key regulator of human health, influencing not only metabolism and immunity but also the development and treatment of cancer. Mounting evidence suggests that microbial dysbiosis contributes to oncogenesis by driving chronic inflammation, producing genotoxic metabolites, altering bile acid metabolism, and disrupting epithelial barrier integrity. At the same time, the gut microbiome significantly modulates the host response to oncotherapies including chemotherapy, radiotherapy, and especially immunotherapy, where microbial diversity and specific taxa determine treatment efficacy and toxicity. This review synthesizes current evidence on the role of the gut microbiome in both oncogenesis and oncotherapies, focusing …

Mechanical Improvements And Control Implementation On A Biomimetic Quadruped Model, Matthew Jack Lutz

Dissertations and Theses

Robotic development started billions of years after earth first began biological prototyping. While the evolutionary process in animals is quite different from robotic prototyping, it still remains no surprise that animals remain more agile, more efficient, and more adaptable than even the most advanced engineered robots to date, simply due to the sheer length of their improvement process. While bridging this improvement gap between deficits in robots and the abilities of animals is difficult, a specific subfield of robotics engineering has attempted to do so using biomimetic robotics. At Portland State, the Agile and Adaptive Robotics Lab (AARL) studies these …

Regenerative And Wellness Medicine: A Boon Or Barrier To Surgical Innovation In Degenerative Spine Care?, Álvaro Dowling, Kai-Uwe Lewandrowski, Morgan P. Lorio, Óscar L. Alves, Rossano Kepler Alvim Fiorelli, Sergio Luis Schmidt, Hansen A. Yuan, Alexander R. Vaccaro

Department of Orthopaedic Surgery Faculty Papers

BACKGROUND: Regenerative and wellness medicine is rapidly reshaping health care, particularly in the management of degenerative spine conditions. Noninvasive or minimally invasive options such as stem cell therapy, platelet-rich plasma (PRP) injections, and holistic wellness programs are increasingly selected by patients who wish to avoid the risks, costs, and prolonged recovery associated with elective spine surgery.

PURPOSE: This perspective article examines whether regenerative and wellness approaches function primarily as a boon or a barrier to innovation in spine surgery and explores their impact on traditional, insurance-based surgical care models.

METHODS: Using a narrative, opinion-based framework, this article synthesizes current trends …

Work-Related Musculoskeletal Disorders: Epidemiology, Risk Factors, Socioeconomic Impact And Prevention - A Narrative Review, Swarna Radhakrishnan, Harini Ramendran, Priyanga Thirunavukkarasu

Digital Journal of Clinical Medicine

Abstract

Work-related musculoskeletal disorders (WMSDs) represent one of the most pervasive and costly occupational health challenges worldwide. Affecting muscles, tendons, ligaments, nerves, joints, and supporting blood vessels, these conditions arise from a complex interplay of physical, psychosocial, organizational, and individual risk factors present across diverse work environments. From factory floors and construction sites to offices and healthcare settings, WMSDs contribute substantially to pain, disability, reduced productivity, absenteeism, and diminished quality of life. This narrative review synthesizes existing literature on the epidemiology, pathophysiology, risk factors, and socioeconomic impact of WMSDs, with particular attention to high-risk occupational sectors. It further discusses prevention …

A Return To The Real: Elder Wisdom, Story, And The Great Mystery Of Consciousness, Patrice V. Mathon-Nerad Phd

Journal of Conscious Evolution

This essay honors the life and legacy of consciousness scholar Allan Leslie Combs by exploring elder wisdom as an epistemic, ethical, and spiritual stance grounded in openness to the great mystery of consciousness. Drawing on Combs’s writings, Charlene Spretnak’s articulation of the Real, and Malidoma Somé’s teachings on elderhood, the essay contrasts elder understanding with contemporary psychiatric approaches that impose epistemic certainty upon the vastness and lived complexity of human consciousness. Portions of this essay are adapted from the author’s 2023 doctoral dissertation, Separation from the Real: The Power of Story at the Heart of the Civil Commitment Process, …

Management Of Anterior Teeth Affected By Molar Incisor Hypomineralization Using Resin Infiltration Technique: A Case Report, Atika Bouabid, Selsebil Laajimi, Yamina Elelmi, Fatma Masmoudi, Ahlem Baaziz

International Arab Journal of Dentistry

Background: Molar-Incisor Hypomineralization (MIH) is a developmental enamel defect affecting first permanent molars and often incisors, presenting unique restorative challenges. In line with minimally invasive dentistry, the “Würzburg concept” promotes conservative management strategies with resin infiltration.

Objectives: This case report investigates the impact of modifications to the ICON resin infiltration protocol on esthetic outcomes and adhesion in MIH-affected anterior teeth.

Method: Three clinical cases involving MIH lesions on anterior teeth were treated using the Icon® resin infiltration system by DMG (Hamburg, Germany).

Results: Preconditioning hypomineralized enamel with 5.25% sodium hypochlorite followed by resin infiltration enhances the physical integrity of composite …

Comparative Evaluation Of The Solubility Of Three Commonly Used Root Canal Sealers When Exposed To Xylene And Endosolv: An In Vitro Study, Aparna Palekar, Piyush Mantri, Basawaraj Biradar, Mukund Singh, Vaidehi Joshi, Pushpal Ingle

International Arab Journal of Dentistry

Objectives: This in vitro study compared the solubility of three root canal sealers, AH Plus (epoxy resin-based), MTA Fillapex (MTA-based), and Cerafill RCS (bioceramic), in two solvents: Xylene and Endosolv.

Methods: Sixty standardized cylindrical specimens were prepared using the three sealers of interest. The specimens were divided into six groups (n = 10) and immersed in either Xylene or Endosolv for 10 minutes. Solubility was assessed by calculating the percentage weight loss before and after immersion. Data were analysed using one-way ANOVA and Tukey’s post hoc test (α= 0.05).

Results: All sealers exhibited statistically significant solubility in both solvents (p …

Interdisciplinary Full-Mouth Rehabilitation Addressing Midline Shift And Gingival Discrepancies Through Crown Lengthening And Root Reshaping Procedures: A Case Report, Ghida Lawand, Roudy Khayat, Stephanie Khalaf, Tamara Rebeiz, Hani Tohme

International Arab Journal of Dentistry

This report describes a minimally invasive approach to address midline deviation and gingival discrepancies in a 50-year-old patient seeking rapid aesthetic results. Treatment included prosthetic crown lengthening, selective root modification, and biologic shaping to correct a 3 mm midline shift. Digital smile design and CAD/CAM technology guided the fabrication of zirconia restorations, achieving improved midline alignment, gingival harmony, and smile aesthetics with high patient satisfaction. This technique provides an efficient alternative for complex aesthetic cases.

Evaluating The Analgesic Activity Of The Ethanolic Leaf Extract Of Ipomoea Aquatica (Convolvulaceae), Blessy H. Vale, Lenny Shai Somer, Julie Mae Suico, Roselle L. Remulta, Junnin Gay Garay

Pacific Journal of Health

Ipomoea aquatica, commonly known as water spinach, is a leafy vegetable widely consumed in tropical and subtropical regions for its nutritional benefits. This study investigated the potential analgesic activity of the ethanolic leaf extract of I. aquatica, as no prior scientific evidence supports its role in acute pain management. Male Swiss albino mice were used in an acetic acid-induced writhing test, with aspirin as the positive control and plain normal saline solution (PNSS) as the negative control. The extract was administered at low, medium, and high doses. In the writhing test, I. aquatica significantly inhibited the writhing response …

Information System To Elucidate Dna Sequencing Based On Machine And Deep Learning Techniques, Suhiar Mohammed Zeki Abd Alsammed

Baghdad Science Journal

The elucidation of DNA sequencing provides great importance in increasing the comprehension of organisms' genomic functions. However, the investigation of concealed structural information preserved within Deoxyribonucleic Acid (DNA) sequencing represents an outstanding challenge. Recently, machine and deep learning have become the techniques of preference for various tasks of genomics modeling, involving the prediction of genetic variation influence on the mechanisms of gene regulation like DNA receptivity and splicing. Therefore, this paper presented an information system for elucidating DNA sequencing data using diverse machine and deep learning techniques. In this system, two encoding methods are utilized for modifying the DNA sequencing …

Happily Ever After?: Romantic Ideas And Gender Roles In Disney Media, Madelyn J. Winfrey

Departmental Honors & Graduate Capstone Projects

This research aims to study a sample of animated Disney movies to examine the gender roles and romantic relationships displayed. With Disney's wide reach in the media realm, they have gained popularity across the globe for the movies they produce; however, the genre they are most well-known for is romance and fairytales. This study will utilize content analysis to examine the behaviors and stereotypes displayed in each movie in the sample as well as common themes that are present.

Folding Architecture “Origami Art-Inspired” Applicability To Sustainable Architecture- Biomuseo As A Case Study, Vitta A. Ibrahim

Mansoura Engineering Journal

The growing need for sustainable architectural solutions in the contemporary era underscores the necessity for interactive architectural applications that can adapt to changing requirements. In architecture, folding systems refer to three-dimensional, foldable structural forms that create unique spatial configurations and possess a wide range of capabilities. Drawing inspiration from origami techniques, this study emphasizes the role of folding systems in generating innovative spatial designs. The research problem arises from the fact that the built environment is a significant contributor to greenhouse gas emissions and energy consumption, necessitating the implementation of smart solutions. The goal of this study is to identify …

Biomechanics Of The Ribs During Respiration At The Costotransverse Joint: An In-Vivo Retrospective Pilot Study, Michael Maninang, Greg Almeter, Erik Pearson, Arvie Vitente

Philippine Journal of Physical Therapy

Introduction: Scarce in‑vivo data describe how ribs move at the costotransverse joints during quiet breathing—knowledge critical to thoracic biomechanics and pain mechanisms. This pilot study uses four‑dimensional computed tomography (4D‑CT) to quantify, for the first time, the three‑dimensional magnitude and direction of rib motion at these joints throughout quiet respiration.

Methods: This retrospective, descriptive pilot study analyzed ten 4D‑CT scans obtained from patients undergoing thoracic imaging prior to radiation therapy. End‑expiration and end‑inspiration phases were aligned with a demons deformable‑registration algorithm. For each costotransverse joint, the three‑dimensional displacement vector, its absolute magnitude, and its components along the lateral–medial (L–M), …

Investigation Of Regulated Cell Death (Rcd) Modalities Induced By Copper(Ii), Manganese(Ii) And Silver(I) Complexes Containing Bridging Dicarboxylate And 1,10-Phenanthroline Ligands, Ella O'Sullivan

Doctoral

With the increasing global cancer burden in recent years, there is an urgency to develop novel chemotherapeutic agents. Transition metal complexes represent an attractive class of candidates, owing to their unique electronic and stereochemical properties, as well as their capacity for ligand exchange, redox activity, and catalytic reactivity. These characteristics enable cellular signalling mechanisms that lead to tumour cell cytotoxicity via regulated cell death (RCD) mechanisms. The conventional RCD mechanisms of apoptosis and autophagy are attractive targets for the development of novel complexes because tumour cells evade apoptosis but use autophagy as a survival mechanism when under stress. Therefore, novel …

A Spatiotemporal Model Of Cxcl10 As A Master Regulator Of Immune Evasion And Metastasis In Osteosarcoma, Benjamin B Gyau, Tsz-Kwong Man

Faculty, Staff and Students Publications

The C-X-C motif chemokine ligand 10 (CXCL10) is implicated in the progression of osteosarcoma (OS), the most aggressive pediatric bone malignancy. However, its role often presents a profound clinical paradox: although high circulating levels are strongly linked to poor prognosis, its canonical function is to recruit anti-tumor immune cells. This review unravels these contrasting roles by proposing a novel spatiotemporal model. We argue that in the early stages, immune-evading OS cells initiate the formation of a pre-metastatic niche (PMN) in the lungs, creating a localized inflammatory environment that becomes the primary source of elevated circulating CXCL10. As the disease progresses, …