Digital Commons Network^™

Antagonistic Effects Of Glucagon And Insulin On 5-Fluorouracil Efficacy In Colorectal Cancer, Gabriel M. Randolph, Andrea Florian

SPARK Symposium Presentations

Prior research on the combined effects of insulin and glucagon with low-dose chemotherapy in cancer treatment has yielded contradictory conclusions. Insulin potentiation therapy (IPT), a longstanding but understudied approach, is broadly claimed to enhance chemotherapeutic efficacy; however, it has also been characterized as pseudoscience lacking physiological merit. Adding further complexity, glucagon, insulin's antagonist hormone, has been shown to produce anti-cancer effects when combined with chemotherapeutic agents. The present study aims to observe the individual effects of both hormones on colorectal cancer cells in combination with 5-Fluorouracil (5-FU), to clarify their respective roles in combination therapy. Through the modulation of both …

Evaluation Of The Physical Properties And In Vitro Safety Of Chitosan-Quercus Infectoria Topical Gel, Rani Naga Rakshitha Tillapudi

Theses, Dissertations and Capstones

Due to ongoing inflammation, inadequate blood flow, oxidative stress, and reduced tissue regeneration, chronic diabetic wounds heal slowly, which is a serious health concern. It is important to examine novel strategies that tackle these issues because conventional treatments frequently fail. Therefore, this study examined the physical properties and biocompatibility of a novel topical gel formulated with chitosan and Quercus infectoria gall extract.

Over 28 days, pH, spreadability, texture, homogeneity, color, and drug concentration were assessed. UV-visible spectrophotometry and FTIR analysis were used to establish chemical stability. The MTT assay was used to test its safety in human dermal fibroblast adult …

Mitochondrial Transfer To Granulocytic Myeloid-Derived Suppressor Cells Augments Immunosuppressive Activity, Prabhakar Arumugam, Cortney E. Heim, Rachel W. Fallet, Dhananjay Shinde, Vinai Chittezham Thomas, Rafael J. Argüello, Tammy Kielian

Journal Articles: Pathology and Microbiology

The anti-inflammatory properties of granulocytic myeloid-derived suppressor cells (G-MDSCs) promote Staphylococcus aureus (S. aureus) biofilm persistence. Evidence suggests that G-MDSC activity is shaped not only by S. aureus products but also by intrinsic metabolic programs. This study explores whether G-MDSC activity can be modulated by increasing mitochondrial abundance using a co-culture paradigm with macrophages as a mitochondrial donor. Macrophages transfer mitochondria directly to G-MDSCs via tunneling nanotubes, enhancing G-MDSC respiration, as reflected by increased basal, maximal, and spare respiratory capacity. Augmenting mitochondrial abundance in G-MDSCs enhances T cell-suppressive activity and reduces tumor necrosis factor (TNF) and interleukin 6 (IL-6) production. …

Data File For Tracking Pesticide Accumulation In Juvenile Chinook Salmon During Outmigration Through The Sacramento-San Joaquin River Delta, Hadis Miraly, S.D.M Chinthaka, Kara E. Huff Hartz, Jacob Stagg, Shawn Acuña, Gregory Whitledge, Louise Cominassi, Amelie Segarra, Nann A. Fangue, Richard E. Connon, Michael J. Lydy

Data Sets

Tables of pesticide residue analysis for field-caught, pre-exposure hatchery control, and cage-exposed juvenile Chinook salmon, corresponding quality assurance and quality control data

Seagrassnet Monitoring In The Great Bay Estuary, Nh/Me Field Season 2025, Kalle Matso, Lara Martin, Christopher Whitney, Trevor Mattera, Amanda Giacchetti, David M. Burdick, Thomas Gregory

PREP Reports & Publications

No abstract provided.

Hfpo-Da Aquatic Toxicity And Bioaccumulation, Bailey Dawn Rappold

Theses, Dissertations and Capstones

Per- and polyfluoroalkyl substances (PFAS) have been detected globally in environmental media and biota. Legacy compounds PFOA and PFOS have been observed to be toxic and bioaccumulative in low doses and have been removed from production and industrial processes. Replacement PFAS chemicals are less understood and present a gap in current knowledge in their toxicological effects. This research utilized extended chronic toxicity studies to assess the impacts of HFPO-DA, a short chain replacement PFAS, on the standard aquatic toxicology organism Pimephales promelas. Organisms were exposed for 29 to 30 days at environmentally relevant concentrations of the toxicant, 7.8125 ng/L …

Development And Validation Of An Analytical Method For Quantitative Determination Of Small Aldehydes In Plasma, Stephanie T. Clark

Chemistry & Biochemistry Theses - Archive

Small aldehydes such as formaldehyde and acetaldehyde are highly reactive metabolites that play important roles in biological processes related to oxidative stress, metabolism, and DNA damage. Because of their chemical reactivity, volatility, and low endogenous concentrations, accurate measurement of these compounds in biological samples remains analytically challenging. The goal was to develop and evaluate a practical analytical method for detecting small aldehydes in biologically relevant matrices using headspace gas chromatography mass spectrometry (HS-GC-MS). The method combined chemical derivatization with O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine (PFBHA) and headspace sampling to stabilize aldehydes and enable selective detection by mass spectrometry. Method development focused on optimizing derivatization …

Development Of A Physiologically Based Pharmacokinetic (Pbpk) Simulation Model For Nicotine, Brian Kim, Sung Hun Bae, Mohamed Bashar, Bofang Yi, Mohammad Asikur Rahman, Prince Awuah, Matthew Hartog, Rony Panarsky, Tao Zhang

Pharmacy Faculty Scholarship

Tobacco is a major cause of chronic diseases such as lung cancer, cardiovascular disease, and chronic obstructive pulmonary disease worldwide. Nicotine, the primary psychoactive component in tobacco, is highly addictive and while not the primary driver of such tobacco-related diseases, poses various health risks, particularly those affecting the cardiovascular and pulmonary systems. Although nicotine-based therapies, such as nicotine replacement products, are widely utilized in smoking cessation efforts today, the impact of newer, tobacco delivery systems such as electronic nicotine delivery systems, or ENDS, remains uncertain and warrants continued evaluation. This study aims to develop and validate a physiologically based pharmacokinetic …

Meta-Analysis: Diabetes Mellitus And The Risk Of Endometrial Cancer, Tricia Ho, Marika Ongpauco, Han Ha Ngoc Nguyen

Physician Assistant Studies | Graduate Research Papers

Background: Many studies have looked at the relationship between diabetes mellitus and development of endometrial cancer. This study provides an updated systematic review and meta-analysis of the estimated effect of diabetes and the risk of endometrial cancer.

Methods: Some studies were found on databases such as PubMed and Iceberg. The remaining studies were extracted from the initial studies found. Binary data was collected and the raw data was imputed into a Fixed Effects Model.

Results: A total of 25 studies were included in this meta-analysis, generating statistically significant results (p < 0.001, OR 2.05, 95% Cl 1.92-2.19).

Discussion: Diabetes is found to be …

Downstream Persistence Of Cyanobacteria In New Jersey's Raritan River Basin, Kyle R. Clonan, Meiyin Wu, Heather Heckathorn, Heather A. Desko, Eric Ernst, Pam Reilly, Bob Schuster, Robert Newby, Annie C. Hurley, Alessandra Rossi

Department of Biology Faculty Scholarship and Creative Works

Few studies have examined cyanobacteria persistence starting from lacustrine cyanobacteria harmful algal blooms (HABs) downstream. Multiple lakes and reservoirs within New Jersey's Raritan Basin Water Supply Complex (RBWSC) feature recurrent HABs and discharge water into the Raritan River. As the RBWSC provides drinking water to 1.5 million people, these HABs create drinking water treatment and human health concerns. This study quantitatively reviews the persistence of cyanobacteria communities across the RBWSC from cyanobacteria-dominated lacustrine sources to downstream drinking water and qualitatively assess what, if any, water chemistry parameters influenced the persistence, growth, or decline of cyanobacteria during downstream transport. Statistical tests …

From Fog To Function: An Occupational Therapist's Guide To Evaluating And Treating Cancer-Related Cognitive Impairments, Lauren E. Toner

Entry-Level Occupational Therapy Doctorate - Doctoral Capstone Symposium

Cancer – related cognitive impairment (CRCI) is a common side effect of cancer treatment that interferes with cancer survivors’ occupational performance, independence, and quality of life. Despite its high prevalence, CRCI remains under recognized and inconsistently addressed within oncology care. About 70% of individuals diagnosed with cancer report cognitive changes during or after treatment, yet many do not receive treatment. Occupational therapists are clinically trained to evaluate and treat functional cognition, activities of daily activities, instrumental activities of daily living, and client centered goals, positioning them as key providers in addressing CRCI. However, limited occupational therapy specific resources have hindered …

Storytelling, Perspective, And Interpretation In Sergei Parajanov’S Shadows Of Forgotten Ancestors, Alexandra Denner

Theses & ETDs

No abstract provided.

Lymphoma, Children's Health School Services

School Guides

Educator guide about how to support students with lymphoma.

Practical Considerations For Conducting Canine Behavioral Science, Lucrezia Lonardo, Madeline H. Pelgrim, Jeffrey R. Stevens

Jeffrey Stevens Publications

Research on behavior in domestic dogs (Canis familiaris) has increased rapidly recently due to the interest in them as pets, working dogs, and model species for understanding evolution, domestication, and even human health. This interest in canine behavioral science has resulted in the creation of dozens of dog lab worldwide, with more starting every year. Our aim here is to review practical issues that potential dog researchers might consider when deciding how to set up a dog lab and conduct research in canine behavioral science. We hope that this can offer a path forward in promoting high-quality, cutting-edge …

Winter 2026, Office Of University Marketing And Communication

Bryant Magazine (1997-2019)(2024-present)

This issue invites us to reflect on some of the remarkable achievements of the past year and to look ahead with purpose and passion. At the heart of this issue is a theme woven throughout our culture: working together, collaboration, and partnership, best summarized as teamwork.

A Stable Isotope Comparison Of The Biogenic Carbonate Of Mammalian Tooth Enamel From The Modern Ohio River Valley And Fort Ancient Buffalo Sites, Sara Elizabeth Slack

Theses, Dissertations and Capstones

δ¹⁸O and δ¹³C values change in response to anthropogenic factors (Ghosh & Brand, 2003). Little is known about the effects of anthropogenic climate and land use change on the ecology of the Ohio River Valley. The goal of this research was to quantify the effects of European colonization on the native ecology of the region. The specific questions of this research were: (1) How have mammalian tooth enamel δ¹⁸O and δ¹³C compositions shifted over time within the Ohio River Valley in response to anthropogenic climate change and vegetation? (2) Are there differences …

Effect Of Environmental Conditions On German Cockroach (Blattella Germanica) Behavior And Survival, Allison Lopina

Theses and Dissertations--Entomology

German cockroaches (Blattella germanica L.) remain one of the most challenging indoor pests to manage, due to resistance to many commonly used insecticides, and necessary contact/interaction with common management tactics. As such, it is critical to fully understand their aggregation, movement, and longevity, such that treatments can be optimally placed to result in maximal efficacy. The first part of this study explored the effects of multiple factors (harborage width, harborage materials, heat, resource-harborage distance) on initial site selection, and how environmental modifications and infestation density impact harborage site switching. The second half of the study aimed to explore the …

Moisture Performance Of Coated Cross-Laminated Timber Under Coastal Conditions In Vertical And Horizontal Orientations With And Without Weather And Vapor Resistive Barriers, Mia Raley

Engineering Theses

Rhode Island is experiencing sea level rise, and more flooding and erosion during storm events due to climate change. The Rhode Island construction industry wants to adopt mass timber, but have concerns with the changing coastal environment on cross-laminated timber (CLT) wall and slab panels. This research aims to understand how coastal conditions affect CLT under different protection conditions, panel orientations, and structure type, by collecting moisture and temperature data on two structures, one commercially-fabricated and one laboratory-fabricated, located on Shell Path from early-July to early-April. Results found that all layers of horizontally-oriented panels benefitted from an additional protective weather-resistant-barrier …

Integrated Management Of Diplodia Ear Rot And A Comparison Of Stenocarpella Species Affecting Corn, Luke C. Warner

Theses and Dissertations--Plant Pathology

Corn is a globally important crop used for food, feed, and ethanol production, but often the grain quality is threatened by Diplodia ear rot, caused by Stenocarpella maydis and Stenocarpella macrospora. Effective management of Diplodia ear rot is difficult to achieve. This study evaluated the efficacy of foliar fungicides, including products listed by the Organic Material Research Institute (OMRI), against S. maydis in vitro and in field settings, as well as comparingthe aggressiveness of the two causal pathogens of Diplodia ear rot. The in vitro assays indicated a wide variation in sensitivity of S. maydis to the fungicide active ingredients, …

First Amendment Protection For Unlicensed Wellness Coaches, Barbara Zabawa

Faculty Works

This article examines the constitutional implications of state efforts to license unregulated wellness practitioners, particularly wellness coaches. As occupational licensing expands, wellness services—ranging from nutrition counseling and life coaching to mindfulness and holistic practices—face increasing scrutiny. The paper argues that most wellness coaching involves speech rather than conduct and therefore qualifies for First Amendment protection. Drawing on Supreme Court and lower court precedent, it distinguishes between professional judgment that may justify state regulation and speech-based coaching practices that pose minimal risk of harm. The analysis situates wellness coaching within broader debates over professional regulation, consumer empowerment, and the marketplace of …

A Comprehensive Statistical And Regional Analysis Of Lng-Powered Marine Vessels On Ghg Mitigation Strategies Considering Existing Bunkering Stations And Gwp Values, Canberk Hazar, Onur Yuksel, Murat Bayraktar

Journal of Marine Science and Technology–Taiwan

This study aims to quantify and analyse emissions from marine vessels that can operate on liquefied natural gas (LNG) but continue to use conventional fuels, largely due to the limited availability of LNG bunkering stations (BSs) over long distances. Four regions have been identified as having high concentrations of LNG-fueled vessels but limited access to operational BSs: the West Coast of the United States of America (USA), South Africa–Good Hope–Madagascar, Northwest Africa, and Brazil. This selection is based on the geographical distribution of these ships and the existing infrastructure. Hourly greenhouse gas (GHG) emissions have been calculated by considering the …

The Jevons Filter: Why Civilizations May Fail Before Reaching “Type I” Status, Giray Fidan

Comparative Civilizations Review

Humanity’s accelerating energy use poses profound questions about the long-term viability of technological civilization. This paper introduces the “Jevons Filter” hypothesis: a self-reinforcing feedback loop between efficiency improvements and rising aggregate consumption, rooted in the classical Jevons Paradox that systematically drives civilizations toward resource depletion and environmental thresholds. Here we argue that this feedback constitutes a critical developmental barrier, hindering sustainable progression toward Kardashev “Type I” energy mastery. We develop a simplified thermodynamic model linking energy efficiency, economic expansion, and civilizational dynamics, and engage with counterarguments regarding absolute decoupling and transformative technological innovations. Building on the classical Jevons Paradox, this …

Planaria Dugesia Japonica As A Model Organism For Measuring The Toxicity Of Environmental Contaminants Per- And Poly-Fluoroalkyl Substances (Pfas), Caitlyn Rodeo

Behavioral Neuroscience Honors Papers

A group of synthetic chemicals, per- and poly-fluoroalkyl substances (PFAS) are ubiquitous in the environment and have significant detrimental effects on physiology and behavior. Planaria have recently increased in popularity as a model for toxicology and regeneration research. These organisms possess a primitive centralized nervous system that is thought to be more similar to the vertebrate brain than to other invertebrate brains in terms of structure and function, and possesses the same neuronal subpopulations and neurotransmitters as the mammalian brain. While other studies have investigated the behavioral effects of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) on planaria, there is …

How Should The Law Treat Future Ai Systems? Fictional Legal Personhood Versus Legal Identity, Heather Alexander, Jonathan Simon, Frédéric Pinard

Journal of Law, Technology, & the Internet

The law draws a sharp distinction between objects and persons, and between two kinds of persons, the ''fictional'' kind (i.e. corporations), and the ''non-fictional'' kind (individual or ''natural'' persons). This paper will assess whether we maximize overall long-term legal coherence by (A) maintaining an object classification for all future AI systems, (B) creating fictional legal persons associated with suitably advanced, individuated AI systems (giving these fictional legal persons derogable rights and duties associated with certified groups of existing persons, potentially including free speech, contract rights, and standing to sue ''on behalf of'' the AI system), or (C) recognizing non-fictional legal …

Aster Remote Sensing Satellite Imagery For Regional Mineral Mapping In The Mcmurdo Dry Valleys, South Victoria Land, Antarctica, Khurram Riaz, Amin Beiranvand Pour, Jabar Habashi, Aidy M. Muslim, Iman Masoumi, Ali Moradi Afrapoli, Mazlan Hashim, Kamyar Mehranzamir, Farshid Sattari

Mining Engineering Faculty Publications

The McMurdo Dry Valleys (DVs) of South Victoria Land, Antarctica, constitute the largest ice-free region on the continent and one of Earth’s most Mars-analog environments. Their hyper-arid polar desert conditions offer a unique setting for investigating surface weathering and mineralogical processes under extreme climates. This study presents the first regional-scale mapping of alteration and crystalline weathering minerals across the McMurdo DVs. It uses Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) multispectral data; visible and near-infrared (VNIR) and shortwave infrared (SWIR) bands were analyzed through a Spectral Hourglass Workflow, endmember extraction, and spectral unmixing with Matched Filtering (MF) and Constrained …

Clinical And Biochemical Effects Of Intra-Articular Autologous Conditioned Serum And Triamcinolone In An Equine Model Of Synovitis, Ana Velloso Alvarez, Anne Wooldridge, Fred Caldwell, Sandra Zetterström, Bruno C. Menarim, Taylor J. Towns, Emily C. Graff, Lindsey Boone

Veterinary Science Faculty Publications

Synovitis is a key contributor to the development of OA, and early modulation of the synovial environment may help limit downstream cartilage damage. This study compared the clinical and biochemical effects of intra-articular triamcinolone acetonide (TA) and autologous conditioned serum (ACS) in an equine model of IL-1β–induced synovitis. Six healthy adult horses were used in a crossover design involving five groups: PBS (negative control), IL-1β (positive control), IL-1β + ACS, IL-1β + TA, and an exploratory ACS-alone group administered post hoc to isolate its effects without IL-1β interference. Both TA and ACS mitigated inflammation through distinct profiles. TA was superior …

Music, Eeg And Stress: Connections Between Music And Electroencephalographic Patterns And The Mediation Of Physiological And Psychological Stress, Alexa Warren

Behavioral Neuroscience Honors Papers

The interrelation between music and the brain is an evolving interdisciplinary interest within neuroscience research. Relying on the capacity of music to elicit emotional and physical responses, as well as scientific principles like entrainment, this area of research explores the potential for utilizing targeted music as a holistic non-pharmacological therapeutic intervention. This is often executed via musical entrainment, which is the basis for this study. Utilizing a complex, yet elegant design, this research incorporates a cross disciplinary approach into a randomized controlled study bridging science and the arts. The purpose of this study is to expand this body of knowledge …

Expectancy Effects On Mental Fatigue, Ethan Li

Behavioral Neuroscience Honors Papers

This thesis explores mental fatigue as a state arising from sustained cognitive demand and explores the use of the gradual-onset performance task (gradCPT) for mental fatigue research. The study examines whether expectancy effects (placebo or nocebo conditions) influence mental fatigue-related outcomes. Expectancy effects were induced by asking participants to view an inert optical illusion after describing its benefits (placebo) or harms (nocebo) to mental fatigue. Out of 73 participants, results showed significant decreases in performance over time, along with significantly increased subjective fatigue as measured by the VAS-F subscale, supporting gradCPT as an effective fatigue inducer in short periods of …

Caught In The Midwife’S Hands: A Black Feminist Exploration Of Reproductive Health And Justice In Massachusetts, Nina Bakum

Gender, Sexuality, and Intersectionality Studies Honors Papers

No abstract provided.

“Which Side Are You On?”: The Historical Creation And Political Implications Of An Appalachian White Other, Zoe Davin

History Honors Papers

No abstract provided.