Digital Commons Network^™

Creative Works By Lauren Rothgeb, Lauren Rothgeb

The Art of Medicine

• Noordwijk
• Museo Reina Sofía
• Playa de Itzurun, Zumaia

The Genetic Role Of Prnp, Julianna Dufresne

Student Research Design & Innovation Symposium

Located on chromosome 20, the prion protein gene (prnp) is responsible for neuronal health and supporting healthy brain function. Missense mutations in specific areas of the gene, however, result in an abnormally folded protein, referred to as a prion. When the abnormally folded version of the prion protein comes into contact with normally folded proteins in the brain, it causes the regular protein to misfold, creating a cascade effect. The neurodegenerative disorders that result from mutated PRNP present similarly, but are distinguished from each other by where exactly in the gene the mutation occurred. Creutzfeldt-Jakob Disease is one of the …

Creative Works By Aaron Allison, Aaron Allison

The Art of Medicine

• Fill Your Cup

Art Of Medicine - 2026

The Art of Medicine

No abstract provided.

Suspected Cornual Ectopic Pregnancy In A Bicornuate Uterus Following In Vitro Fertilization, Jacqueline Baron, Natalie Canuteson

West Florida Division GME Research Day 2026

No abstract provided.

From The Desk Of The Editors: Dr. Alex Garcia-Putnam And Amelia Sethi (Student Co-Editor), Alex Garcia-Putnam, Amelia Sethi

Spectrum

No abstract provided.

How Racial Discrimination Accelerates Biological Aging, Leah Maddison

Spectrum

No abstract provided.

Poverty And Health: Skeletal Evidence Of Syphilis At Charity Hospital Cemetery #2, New Orleans, Louisiana (1842-1929), Connor Lincoln

Spectrum

No abstract provided.

From Gravestones To People: Mortuary Archaeology And Microhistory At North Cemetery, Portsmouth, Nh (1753-1926), Juliet O’Brienhalla

Spectrum

No abstract provided.

Clonal Expansion Of Cytotoxic Cd8⁺ T Cells In Lecanemab-Associated Aria, Lance A. Johnson, Kai Saito, Akhil V. Pallerla, Jessica L. Funnell, Ashley R. Ezzo, Chelsea M. Song, Douglas A. Harrison, Noah J. Norton, Lauren C. Moore, Linda J. Van Eldik, David W. Fardo, Greg E. Cooper, Josh M. Morganti

Sanders-Brown Center on Aging Faculty Publications

Amyloid-related imaging abnormalities (ARIA) are the principal safety concern limiting anti-amyloid therapies for Alzheimer’s disease, yet their biology remains unclear. Here we show, through multi-omic profiling of peripheral blood from three ARIA+ patients and matched controls, that ARIA is associated with coordinated reprogramming of CD8 + T cells. CD8+ effector memory (TEM) and terminally differentiated (TEMRA) subsets were expanded, clonally enriched, and transcriptionally primed for cytotoxicity and vascular trafficking. Transcription factor inference and metabolomics converged on glycolytic reprogramming favoring short-lived effector function. Ligand-receptor modeling revealed enhanced monocyte-to-T cell signaling through antigen presentation, adhesion, and chemokine axes, while integration with a …

Rusty Spears '81-Anne Baade '81, Robert Spears, Anne Baade

Alumni Oral History Project

No abstract provided.

Designing Theranostic Radiopharmaceutical Trials For Uterine Cervix Cancer, Denise Fabian, Molly E. Buffington, Brianna S. Cagle, Steve M. Keefe, Michael K. Schultz, Charles A. Kunos

Radiation Medicine Faculty Publications

Designing and interpreting early phase trials of theranostic radiopharmaceuticals remains challenging because it is difficult to isolate effective levels of activity in enriched patient populations that would be worth following up in later-phase development. This study explores the known challenges and emerging opportunities for clinical research on patients with uterine cervical cancer. We identified eight randomized combination trials for advanced-stage uterine cervix cancer that were activated between 2011 and 2022 and tabulated their results to determine whether combinations were better than individual constituents and which suitable study population is best situated for the study of a new theranostic agent. In …

The Presence Of Predators Moderates Evolutionary Responses Of Trinidadian Killifish To A Novel Parasite, Anne E. Christian

Biology Dissertations

The Healthy Herds Hypothesis suggests the idea that prey populations derive a benefit from their predators: predators reduce the exposure of their prey to infectious disease, both by limiting prey population densities and by eliminating sick individuals. Much research has focused on the balancing effect that predators have on ecosystems. There is a current need for research into whether these effects cause evolutionary shifts in prey populations, where strong predation pressure prevents prey species from evolving physiological tolerance or resistance to infectious agents. Parasites especially often have rapid effects on host evolution, due to exploitative interactions.

I seek to address …

Artificial Intelligence Methods For Circadian Rhythm Recovery And Disease Identification From High-Dimensional Omics Data, Aram Ansary Ogholbake

Theses and Dissertations--Computer Science

High-throughput transcriptomic and proteomic technologies have enabled opportunities for studying biological processes and disease mechanisms. However, extracting meaningful biological information from these high-dimensional datasets remains challenging due to limited sample sizes, biological heterogeneity, measurement noise, and the absence of biological annotations. In particular, many molecular datasets lack temporal information required for circadian analysis, making the study of circadian rhythms difficult. Moreover, disease diagnosis and biomarker discovery from transcriptomic data often rely on complex machine learning models whose predictions are difficult to interpret and may not generalize well across independent datasets and experimental platforms. These limitations motivate the development of artificial …

Ai For Life Sciences: From Geometric Protein Modeling To Multimodal Drug Design, Feng Jiang

Computer Science and Engineering Dissertations

Predicting biomolecular interactions, from immune recognition to drug–target binding, is a central problem in the life sciences and computational drug discovery. Deep learning has advanced this area, yet three challenges persist: the topology of large, highly imbalanced interaction networks; structural noise in computationally predicted protein models; and the integration of multimodal information such as functional text and taxonomic annotations. This dissertation develops a coherent set of models spanning immune complex prediction and small-molecule drug design: graph learning that addresses network topology and severe class imbalance; a noise-tolerant method that fuses predicted structures with evolutionary sequence features; and multimodal representation learning …

2026 Acropolis, Whittier College

Acropolis (Yearbook)

No abstract provided.

From Wikipedia Tables To Public Data Visualizations, Tanvir Prince

Open Educational Resources

This open educational resource presents a practical mathematics lesson in which students turn numerical data from Wikipedia into a clear data visualization. Students select a Wikipedia page with a data table but little or no visual representation. They examine the original source, date, units, definitions, and possible data limits. They then organize the data in Microsoft Excel or another spreadsheet, choose an appropriate chart, and explain what the visualization helps readers understand. A complete worked example uses the 2017 population growth rates of South American countries.

The resource package includes an instructor lesson plan, a student project guide, a Wikimedia …

Evaluation Of Micronized, Electrospun Fiber Matrix Effect On Outcomes Of Major Lower Extremity Amputations., Michael Dearman, Brittany Wagner, Alireza Behbudi, Luis Fernandez, Alan Cook, Rebecca Swindall, Brandi Pero, Alisha Thedford

School of Medicine Student Publications and Presentations

Background: Major lower extremity amputations are associated with substantial postoperative morbidity and mortality (Belmont). Restrata is a synthetic electrospun fiber matrix that is engineered to closely resemble human extracellular matrix to facilitate wound healing while avoiding the drawbacks of traditional biologic wound matrices (MacEwan, Fernandez). There have been no studies which have directly compared micronized electrospun fiber matrix (MEFM) to biologic xenograft matrices in patients undergoing major lower extremity amputation. The purpose of this study is to compare postoperative wound recovery in patients undergoing major lower extremity amputation, treated with MEFM (Restrata Minimatrix, Acera, St.Louis, Missouri ) versus a type …

Evaluation Of Micronized, Electrospun Fiber Matrix Effect On Outcomes Of Major Lower Extremity Amputations, Michael Dearman, Brittany Wagner, Luis Fernandez, Alireza Behbudi, Alan Cook, Rebecca Swindall, Brandi Pero, Alisha Thedford

School of Medicine Student Publications and Presentations

No abstract provided.

Teaching Safety Skills To Young Adults With Intellectual Disabilities In A School Setting, Nicole Freeman

Dissertations and Theses

his study was designed to determine the effectiveness of using Behavior Skills Training with or without In-situ Training to teach responding to a simulated toxic substance in young adults with intellectual disabilities in a school setting. Simulated safety skills were measured using a task-analysis of independently identifying, avoiding, and reporting the simulated toxic substance to a qualified adult (i.e., teacher, caregiver, classroom support provider). The task analysis of the identification, avoidance, and reporting was an attempt to quantify independent self-help skills on the part of the participants. The measurement procedure was consistent with previous research conducted on similar safety skills …

Iron(Ii)/Cobalt(Ii)-Mediated Silicon And Carbon Quantum Dots For Nanozyme Activity And Fluorescence Sensing Of Hydrogen Peroxide And Glucose, Kang Qin

Dissertations and Theses

Silicon quantum dots (SiQDs) and carbon quantum dots (CQDs) have been widely studied as fluorescent nanomaterials for sensing applications. In this thesis, we developed two different nanomaterials, SiQDs and CQDs, and investigated their catalytic activities and applied them for the detection of hydrogen peroxide and glucose. In the first project, Co2+-mediated SiQDs were synthesized through a hydrothermal method. The obtained nanoparticles showed obvious peroxidase-like activity toward the oxidation of tetramethylbenzidine (TMB) in the presence of H2O2 under acidic conditions. Moreover, a weak oxidation of TMB was also observed without H2O2, suggesting the existence of oxidase-like activity. To better understand the …

Invasion Dynamics, Environmental Conditions, And Community Impacts Of Yellow Sweetclover (Melilotus Officinalis) Across The Northern Great Plains, Sakshi Saraf

Dissertations and Theses

Understanding how environmental conditions and invasion dynamics shape native plant Communities is critical for conserving and managing the semi-arid grasslands of the Northern Great Plains (NGP). Invasive plant species are increasingly altering ecosystem structure and function across this region, yet knowledge gaps remain regarding the drivers of invasion, their spatiotemporal dynamics, and their associations with native plant communities. This dissertation investigates three questions: (1) what environmental conditions are associated with the distribution and abundance of the invasive legume Melilotus officinalis (yellow sweetclover; MEOF), (2) how does MEOF vary across space and time under climatic conditions, and (3) how are environmental …

2026 Intersession Catalog, Illinois Math And Science Academy

Intersession Catalogs

No abstract provided.

Forage News [2026-03], University Of Kentucky

Forage News

No abstract provided.

An Autoethnographic Study Of A Technical Services Librarian’S Teaching Journey During The Tenure Track: “Define Myself For Myself To Both Survive And Thrive”, Junli Diao

Publications and Research

This autoethnographic study explores the disorienting dilemma that a technical services librarian experienced while alternating between working behind the scenes to fulfill professional responsibilities and teaching in the library to meet organizational expectations as a faculty member. The analysis of personal data accumulated during the tenure track period reveals three themes: teaching as learning to become, teaching as learning to challenge the system, and teaching as learning to research. Reflection focuses on three themes interconnected by the concept and practice of mindful learning. With the acknowledgement of limitations, this autoethnography concludes it was the self-reflective lifelong learning mindset that helped …

Exploring The Role Of Satisfaction With Love, Education, Work, And Leisure In Flourishing During Emerging Adulthood And Early Established Adulthood, Jonathon J. Beckmeyer, Tyler B. Jamison, Cindy L. Hartman

Faculty Publications - Family and Consumer Sciences

Using data from 857 young adults (18 to 35 years-old), we explored how satisfaction with education, work, romantic, and leisure experiences were associated with flourishing. We found associations between satisfaction and flourishing, even when accounting for having completed salient developmental tasks related to education, work, romantic relationships, and leisure. Although we did not find that gender (cisgender women compared to cisgender men) or developmental stage (emerging adult compared to early established adult) moderated associations between developmental domain satisfaction and flourishing, we did find gender and developmental stage differences in education, work, and leisure satisfaction as well as developmental task completion …

Viral Ecology And Taxonomy At Axial Seamount, Madison Bohan

Student Research Design & Innovation Symposium

Viruses are microscopic infectious agents that can infect all living organisms and are found in every ecosystem on Earth. Despite this abundance, viral communities in deep-sea environments remain understudied. Hydrothermal vent systems are a unique environment of study due to high pressure, extreme temperatures, and lack of sunlight that make environments uninhabitable except for specialized organisms. The goal of this study is to characterize viral families at Axial Seamount and improve our understanding of viral diversity in deep-sea hydrothermal ecosystems. A team of researchers conducted a research cruise along the Pacific Ridge to sample multiple hydrothermal vent systems. Water samples …

Big Tech As Transnational Spyware Regulator, Natalie R. Davidson

Fordham Intellectual Property, Media and Entertainment Law Journal

Spyware has emerged as a potent tool for leaders to shrink dem- ocratic contestation. In response to calls for constraints on the trade in spyware, states have updated the principal multilateral agree- ment on export controls, civil society groups have employed strate- gic litigation, and the European Union has altered its regulation, in each case with the aim of limiting exports where there is a risk of human rights violations. Yet, scandals involving the Israeli company NSO, among others, have made clear that even the updated regula- tory landscape is inadequate. Many actors are currently debating the reasons for existing …

Glial Cytokine Modulation Improves Sleep And Circadian Disruption In Female Saa Knock-In Mice Of Alzheimer’S-Related Pathology, Teresa Macheda, Margaret R. Hawkins, Carrie E. Johnson, Madison G. Lapid, Haleigh R. Whitlock, Savannah M. Shepard, Makayla F. Cox, Kelly N. Roberts, Leke Bytyqi, Heather M. Hash, Omar A. Abou El-Ezz, Mohammed Abou El-Ezz, Katharina Kohler, Sridhar Sunderam, Bruce F. O'Hara, Linda J. Van Eldik, Michael Paul Murphy, Marilyn J. Duncan, Adam D. Bachstetter

Neuroscience Faculty Publications

Introduction: Sleep and circadian disturbances are early Alzheimer's disease (AD) features, yet mechanisms linking amyloid pathology, neuroinflammation, and sex differences remain unclear.

Methods: We longitudinally assessed sleep, circadian rhythms, and cognition in female and male hAPP^SAA knock-in and control mice from 2 to 19 months using piezoelectric monitoring. Aged mice (15 months) received MW151, a glial cytokine inhibitor (2.5 mg/kg, every other day, 6 weeks).

Results: Only females exhibited midlife reductions in light-phase sleep, increased rhythm fragmentation, and reduced rhythm stability, coinciding with selective reversal learning deficits, effects independent of amyloid or cytokine burden. MW151 increased light-phase sleep and …

Nymc Synapse Issue 57, School Of Medicine Student Senate, New York Medical College

The Synapse

No abstract provided.