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Illuminator, Volume 4, Issue 1, Batten College Of Engineering & Technology, Old Dominion University

College of Engineering & Technology Newsletter

Fall 2021 issue of Illuminator, a monthly publication of ODU's Batten College of Engineering and Technology.

Convergence: Eos News And Updates, November 2021, Unh Institute For The Study Of Earth, Oceans And Space

Convergence: EOS News and Updates

No abstract provided.

Assessing The Impact Of Vaccination On Covid-19 In South Africa Using Mathematical Modeling, Musyoka Kinyili, Justin B. Munyakazi, Abdulaziz Y. A. Mukhtar

Applied Mathematics & Information Sciences

The unexpected continuing mushrooming tendency of the COVID-19 epidemic calls for alarm in the entire globe especially with the cropping up of more divergent contagious variants being witnessed. On top of the many non-pharmaceutical measures put in place for containment of the pandemic, pharmacological measures have been incorporated in the battle against the SARS-CoV-2 especially with the commencement of vaccination in the early December 2020. This study develops a deterministic compartmental model that incorporates vaccination as a measure to combat the spread of COVID-19 epidemic. We use the model particularly to assess the potential impact of vaccination in shattering the …

On Dynamical Analysis Of A Prey-Diseased Predator Model With Refuge In Prey, Srinivasarao Thota, Abayomi Ayoade

Applied Mathematics & Information Sciences

In this paper, we propose a mathematical model of a prey-diseased predator model with refuge in prey system. In other words, a prey-predator model with an infectious disease in the prey population is formulated. This model is constituted by a system of three nonlinear ordinary differential equations of first order, which describe the interaction between the infected prey, non-infected prey and predator. The equilibria of the system are derived and the stability analyses of the disease-free and the endemic equilibria are conducted.

Some Properties And Application Of Modified Jacknified Liu-Type Negative Binomial Ridge Regression, Huda M. Alshanbari, Irsa Sajjad, Javid Gani Dar, Abd Al-Aziz Hosni El-Bagoury, Sundus Naji Al-Aziz

Applied Mathematics & Information Sciences

The aim of this paper is to introduce a new estimator for the modified Jackknified Liu Type Negative Binomial. As in the presence of multicollinearity, the Maximum Likelihood Estimator (MLE) is unable to produce valid statistical inference. So, this paper is designed to solve the problem of multicollinearity. Several ridge regression estimators are used for this purpose. Moreover, Monte Carlo simulation and real life data set are applied on the proposed and existing estimators to evaluate the performance of proposed estimator in the case of MSE. The results reveal that our proposed estimator has best performance among all other estimators …

A Framework Of Paracellular Transport Viananoparticles-Induced Endothelial Leakiness, Myeongsang Lee, Nengyi Ni, Huayuan Tang, Yuhuan Li

Open Access Publishing Fund

Nanomaterial-induced endothelial leakiness (NanoEL) is an interfacial phenomenon denoting the paracellular transport of nanoparticles that is pertinent to nanotoxicology, nanomedicine and biomedical engineering. While the NanoEL phenomenon is complementary to the enhanced permeability and retention effect in terms of their common applicability to delineating the permeability and behavior of nanoparticles in tumoral environments, these two effects significantly differ in scope, origin, and manifestation. In the current study, the descriptors are fully examined of the NanoEL phenomenon elicited by generic citrate-coated gold nanoparticles (AuNPs) of changing size and concentration, from microscopic gap formation and actin reorganization down to molecular signaling pathways …

Exploring The Insights Of Science Within The Context Of Asian Christianity Through The Work Of William R. Stoeger, S.J., Lawrence Ng Yew Kim

Jesuit School of Theology Dissertations

The work to relate theology and the findings of modern science, a long-standing one among western scholars, has been, for historical and cultural reasons, largely absent within the context of Asia. Asian theologians engaged in this field appear to do so by employing the perspective of their North American and European colleagues but without contextualizing it within an Asian context, which has been shaped by deeply rooted Asian philosophical foundations and religious traditions.

This dissertation offers a strategy to contextualize the insights of science within the Sinic context of Southeast Asia by appealing to the methodology of a Jesuit priest, …

Notmad: Estimating Bayesian Networks With Sample-Specific Structures And Parameters, Benjamin Lengerich, Caleb Ellington, Bryon Aragam, Eric P. Xing, Manolis Kellis

Machine Learning Faculty Publications

Context-specific Bayesian networks (i.e. directed acyclic graphs, DAGs) identify context-dependent relationships between variables, but the non-convexity induced by the acyclicity requirement makes it difficult to share information between context-specific estimators (e.g. with graph generator functions). For this reason, existing methods for inferring context-specific Bayesian networks have favored breaking datasets into subsamples, limiting statistical power and resolution, and preventing the use of multidimensional and latent contexts. To overcome this challenge, we propose NOTEARS-optimized Mixtures of Archetypal DAGs (NOTMAD). NOTMAD models context-specific Bayesian networks as the output of a function which learns to mix archetypal networks according to sample context. The archetypal …

A New Compound Lifetime Distribution: Ishita Power Series Distribution With Properties And Applications, Anwar Hassan, Nazima Akhtar, Adil Rashid, Arsheed Iqbal

Journal of Statistics Applications & Probability

In this paper, we explore a new family of models for lifetime data called Ishita Power Series family of distributions by compounding a lifetime distribution called Ishita distribution and Power Series distribution. The proposed model has special cases of several lifetime distributions that are very flexible to fit different types of data sets. It is pertinent to mention that the probability density function and hazard rate can take up different forms such as increasing, decreasing and upside down bathtub shapes which are shown through graphs. Some mathematical properties like; moments, moment generating function and order statistics of the new class …

A New Compound Lifetime Distribution: Ishita Power Series Distribution With Properties And Applications, Anwar Hassan, Nazima Akhtar, Adil Rashid, Arsheed Iqbal

Journal of Statistics Applications & Probability

In this paper, we explore a new family of models for lifetime data called Ishita Power Series family of distributions by compounding a lifetime distribution called Ishita distribution and Power Series distribution. The proposed model has special cases of several lifetime distributions that are very flexible to fit different types of data sets. It is pertinent to mention that the probability density function and hazard rate can take up different forms such as increasing, decreasing and upside down bathtub shapes which are shown through graphs. Some mathematical properties like; moments, moment generating function and order statistics of the new class …

Evaluating Large Spontaneous Deletions In A Bovine Cell Line Selected For Bovine Viral Diarrhea Virus Resistance, Aspen M. Workman, Michael P. Heaton, Dennis A. Webster, Gregory P. Harhay, Theodore S. Kalbfleisch, Timothy P.L. Smith, Shollie M. Falkenberg, Daniel F. Carlson, Tad S. Sonstegard

Roman L. Hruska U.S. Meat Animal Research Center: Reports

Bovine viral diarrhea virus’s (BVDV) entry into bovine cells involves attachment of virions to cellular receptors, internalization, and pH-dependent fusion with endosomal membranes. The primary host receptor for BVDV is CD46; however, the complete set of host factors required for virus entry is unknown. The Madin-Darby bovine kidney (MDBK) cell line is susceptible to BVDV infection, while a derivative cell line (CRIB) is resistant at the level of virus entry. We performed complete genome sequencing of each to identify genomic variation underlying the resistant phenotype with the aim of identifying host factors essential for BVDV entry. Three large compound deletions …

Mapping The Hidden Diversity Of The Geophagus Sensu Stricto Species Group (Cichlidae: Geophagini) From The Amazon Basin, A. M. Ximenes, P. S. Bittencourt, V. N. Machado, Tomas Hrbek, I. P. Farias

Biology Faculty Research

South American freshwater ichthyofauna is taxonomically the most diverse on the planet, yet its diversity is still vastly underestimated. The Amazon basin alone holds more than half of this diversity. The evidence of this underestimation comes from the backlog of morphologically distinct, yet undescribed forms deposited in museum collections, and from DNA-based inventories which consistently identify large numbers of divergent lineages within even well-studied species groups. In the present study, we investigated lineage diversity within the Geophagus sensu stricto species group. To achieve these objectives, we analyzed 337 individuals sampled from 77 locations within and outside the Amazon basin representing …

Why Model Order Reduction, Salvador Robles, Martine Ceberio, Vladik Kreinovich

Departmental Technical Reports (CS)

Reasonably recently, a new efficient method appeared for solving complex non-linear differential equations (and systems of differential equations). In this method -- known as Model Order Reduction (MOR) -- we select several solutions, and approximate a general solution by a linear combination of the selected solutions. In this paper, we use the known explanation for efficiency of neural networks to explain the efficiency of MOR techniques.

Kinematic Metric Spaces Under Interval Uncertainty: Towards An Adequate Definition, Vladik Kreinovich, Olga Kosheleva, Victor Selivanov

Departmental Technical Reports (CS)

In the physical space, we define distance between the two points as the length of the shortest path connecting these points. Similarly, in space-time, for every pair of events for which the event a can causally effect the event b, we can define the longest proper time t(a,b) over all causal trajectories leading from a to b. The resulting function is known as kinematic metric. In practice, our information about all physical quantities -- including time -- comes from measurement, and measurements are never absolutely precise: the measurement result V is, in general, different from the actual (unknown) value v …

Gradient Preserved And Artificial Neural Network Method For Solving Heat Conduction Equations In Double Layered Structures, Aniruddha Bora

Doctoral Dissertations

Layered structures have appeared in many engineering systems such as biological tissues, micro-electronic devices, thin  lms, thermal coating, metal oxide semiconductors, and DNA origami. In particular, the multi-layered metal thin  lms, gold-coated metal mirrors for example, are often used in high-powered infrared-laser systems to avoid thermal damage at the front surface of a single layer  lm caused by the high-power laser energy. With the development of new materials, functionally graded materials are becoming of more paramount importance than materials having uniform structures. For instance, in semiconductor engineering, structures can be synthesized from di erent polymers, which result in various values …

Carbon Nano Based Materials And Their Composites For Gas Sensing Applications: Review, Mohamed Morsy

Nanotechnology Research Centre

No abstract provided.

The Utah Statesman, November 1, 2021, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Ultrasound Regulated Flexible Protein Materials: Fabrication, Structure And Physical-Biological Properties., Bowen Cai, Hanling Gu, Fang Wang, Kyle Printon, Zhenggui Gu, Xiao Hu

College of Science & Mathematics Departmental Research

Ultrasound can be used in the biomaterial field due to its high efficiency, easy operation, no chemical treatment, repeatability and high level of control. In this work, we demonstrated that ultrasound is able to quickly regulate protein structure at the solution assembly stage to obtain the designed properties of protein-based materials. Silk fibroin proteins dissolved in a formic acid-CaCl solution system were treated in an ultrasound with varying times and powers. By altering these variables, the silks physical properties and structures can be fine-tuned and the results were investigated with Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron …

Pseudo-Science And ‘Fake’ News ‘Inventing’ Epidemics And The Police State, Babette Babich

Articles and Chapters in Academic Book Collections

No abstract provided.

Indigenous-Led Conservation Reading List, Megan Youdelis, Kim Tran, Elizabeth Lunstrum

Environmental Studies Program Faculty Publications and Presentations

This list compiles literature relevant to the bourgeoning Indigenous-led conservation movement, be that through Indigenous Protected and Conserved Areas (IPCAs, Canada), Indigenous and Community Conserved Areas (ICCAs, global), or various other forms of Indigenous-led governance or co-governance mechanisms that elevate Indigenous rights, responsibilities, and legal traditions. The introductory Colonial Conservation section is not exhaustive, but rather provides context for the main import of the collection, which is to highlight the possibilities, successes, and challenges associated with decolonizing conservation through Indigenous-led governance. The list is global in scope but has been shaped by the Indigenous Circle of Experts’ (2018) report, We …

Women's Basketball Media Guide 2021-22, Wofford College. Department Of Athletics

Media Guides

No abstract provided.

Men's Basketball Media Guide 2021-22, Wofford College. Department Of Athletics

Media Guides

No abstract provided.

The Effect Of Increased Recess Time On The Academic Achievement Of Elementary Students, Mark A. Taylor

ATU Theses and Dissertations 2021 - Present

Arkansas lawmakers enacted Act 641 of 2019, which increased recess time during the school day from 30 minutes to 40 minutes per day. Recess is defined as unstructured free play for students outside when possible. Recess is an important part of the school day. Recess improves social skills, time on task, positive attitudes towards school and increasing physical activity. The purpose of this quantitative study was to determine if increasing recess time for third, fourth and fifth grade elementary students had an impact on ACT Aspire tests results. This study was a quantitative study using a series of independent t-tests. …

The R Journal (December 2021) 13(2): Complete Issue, The R Foundation

The R Journal

On behalf of the R Foundation and the Editorial board, I am pleased to present Volume 13 Issue 2 of the R Journal. This is the biggest issue ever!

First, some news from the Editorial board. A big thank you to Mike Kane, who has finished his term. As Editor-in-Chief in 2020, Mike expanded operations to include Associate Editors in the reviewing process. The R Journal now has a team of 20 Associate Editors. This has helped to manage the increasing number of submissions. We welcome new Associate Editors, Przemek Biecek, Chris Brunsdon, Mine Çetinkaya-Rundel, Kieran Healy, Adam Loy, Priyanga …

The Chanticleer, 2021 November, Coastal Carolina University

The Chanticleer Student Newspaper

The editorially independent student produced weekly newspaper of Coastal Carolina University.

Cetacean Acousticwelfare In Wild And Managed-Care Settings: Gaps And Opportunities, Paige E. Stevens, Heather Hill, Jason N. Bruck

Faculty Publications

Cetaceans are potentially at risk of poor welfare due to the animals’ natural reliance on sound and the persistent nature of anthropogenic noise, especially in the wild. Industrial, commercial, and recreational human activity has expanded across the seas, resulting in a propagation of sound with varying frequency characteristics. In many countries, current regulations are based on the potential to induce hearing loss; however, a more nuanced approach is needed when shaping regulations, due to other non-hearing loss effects including activation of the stress response, acoustic masking, frequency shifts, alterations in behavior, and decreased foraging. Cetaceans in managedcare settings share the …

On The Relationship Between Pain Variability And Relief In Randomized Clinical Trials, Siddharth Tiwari '22

Student Publications & Research

Previous research suggests greater baseline variability is associated with greater pain relief in those who receive a placebo. However, studies that evidence this association do not control for confounding effects (natural history and regression-to-the-mean); for this reason, we analyzed data from two randomized clinical trials (Placebo I and Placebo II, N = 134) while adjusting for confounding effects via a no-treatment group. Results agree between the two placebo groups: both placebo groups showed a negligible correlation between baseline variability and adjusted response (r sp (CI 95% ) = 0.13 (−0.09, 0.37) and 0.01 (−0.15, 0.20) for Placebo I and II, …

U2af1 Is A Haplo-Essential Gene Required For Hematopoietic Cancer Cell Survival In Mice, Brian A Wadugu, Sridhar Nonavinkere Srivatsan, Amanda Heard, Michael O Alberti, Matthew Ndonwi, Jie Liu, Sarah Grieb, Joseph Bradley, Jin Shao, Tanzir Ahmed, Cara L Shirai, Ajay Khanna, Christopher A Miller, Matthew J Walter, Et Al

Open Access Publications

Somatic mutations in the spliceosome gene U2AF1 are common in patients with myelodysplastic syndromes. U2AF1 mutations that code for the most common amino acid substitutions are always heterozygous, and the retained WT allele is expressed, suggesting that mutant hematopoietic cells may require the residual WT allele to be viable. We show that hematopoiesis and RNA splicing in U2af1 heterozygous knockout mice were similar to those in control mice, but that deletion of the WT allele in U2AF1(S34F) heterozygous mutant-expressing hematopoietic cells (i.e., hemizygous mutant) was lethal. These results confirm that U2AF1 mutant hematopoietic cells are dependent on the expression of …

Lab-On-A-Chip Thermoelectric And Solid-Phase Immunodetection Of Biochemical Analytes And Extracellular Vesicles: Experimental And Computational Analysis, Saif Mohammad Ishraq Bari

Doctoral Dissertations

Microfluidics is the technology of controlling and manipulating fluids at the microscale. Microfluidic platforms provide precise fluidic control coupled with low sample volume and an increase in the speed of biochemical reactions. Lab-on-a-chip platforms are used for detection and quantification of biochemical analytes, capture, and characterization of various proteins, sensitive analysis of cytokines, and isolation and detection of extracellular vesicles (EVs).

This study focuses on the development of microfluidic and solid-phase capture pin platforms for the detection of cytokines, extracellular vesicles, and cell co-culture. The fabrication processes of the devices, experimental workflows, numerical analysis to identify optimal design parameters, and …

Oxidative Phosphorylation Is A Metabolic Vulnerability In Chemotherapy-Resistant Triple-Negative Breast Cance, Kurt W. Evans, Erkan Yuca, Stephen S. Scott, Ming Zhao, Natalia Paez Arango, Christian X. Cruz Pico, Turcin Saridogan, Maryam Shariati, Caleb Class, Christopher A. Bristow, Christopher P. Vellano, Xiaofeng Zheng, Ana Maria Gonzalez-Angulo, Xiaoping Su, Coya Tapia, Ken Chen, Argun Akcakanat, Bora Lim, Debu Tripathy, Timothy A. Yap, Maria Emilia Di Francesco, Giulio F. Draetta, Philip Jones, Heffernan P. Heffernan, Joseph R. Marszalek, Funda Meric-Bernstam

Scholarship and Professional Work – COPHS

Oxidative phosphorylation (OXPHOS) is an active metabolic pathway in many cancers. RNA from pretreatment biopsies from patients with triple-negative breast cancer (TNBC) who received neoadjuvant chemotherapy demonstrated that the top canonical pathway associated with worse outcome was higher expression of OXPHOS signature. IACS-10759, a novel inhibitor of OXPHOS, stabilized growth in multiple TNBC patient-derived xenografts (PDX). On gene expression profiling, all of the sensitive models displayed a basal-like 1 TNBC subtype. Expression of mitochondrial genes was significantly higher in sensitive PDXs. An in vivo functional genomics screen to identify synthetic lethal targets in tumors treated with IACS-10759 found several potential …