Digital Commons Network^™

Synthesis Of Novel Fluorescent Molecular Probes For The Diagnosis Of Alzheimer’S Disease, David King, Pradip Bhowmik Ph.D.

Undergraduate Research Symposium Posters

Alzheimer’s Disease (AD) is a pervasive form of dementia that accounts for 60% to 70% of progressive cognitive impairment within the elderly population.1 This neurodegenerative disease manifests itself through a progressive decline in motor function, memory, and cognition.2 AD is closely associated with the accumulation of amyloid- β (Aβ) proteins that form insoluble plaques.2 The formation of Aβ is a hallmark of AD and can serve as a means for diagnosis. Our objective is to synthesize potential candidates for a practical and safe means to detecting AD in its early stages. We synthesized the target fluorescent probes by Knoevenagel condensation …

Predicting Variant Pathogenicity With Machine Learning, Zachary Fitzhugh, Martin R. Schiller Ph.D., Fatma Nasoz

Undergraduate Research Symposium Posters

There are roughly 22,000 protein-coding genes in the human body, many of which play important roles in biological functions. The proteins fold in 3D space, and this is most often necessary for function. A genetic variant can disrupt the secondary structure of a protein (one aspect of structure) or eliminate a site important in protein-protein interaction or post-translational modification. The loss of function or deregulation can result in disease. Thus, there is great biomedical interest in identifying disease-causing single-nucleotide variants.

We hypothesize that we can accurately predict variant pathogenicity. We used machine learning to predict the pathogenicity of a set …

Isolation Of Salt Tolerant Bacteria And Investigation Of Perchlorate Biodegradation At High Salinity Conditions, Aymen Shafique, Yasaman Saedi, Jacimaria Batista Ph.D.

Undergraduate Research Symposium Posters

Perchlorate (ClO4-), known as a highly soluble oxidizer contaminant, has been detected in soil and groundwater throughout the United States for the last two decades. Biological reduction has been seen as a promising technology through which perchlorate reducing bacteria (PRB) occurring naturally in most environments utilize ClO4- as an electron acceptor. However, biological reduction of perchlorate is influenced by high salinity levels because the PRBs’ activity is hindered at salinities over 1%. The goal of this study is to investigate the impact of salinity (NaCl: 0-6.5%) on perchlorate biological reduction. Actual soil samples from the contaminated site containing PRBs were …

Comparison Of Biochar Attained From Various Feedstocks For The Adsorption Of Arsenic In Water, Fabianny Anez, Suraj Pochampally, Christina Obra, Jaeyun Moon, Erica J. Marti

Undergraduate Research Symposium Posters

Water is a fundamental human right, yet in many developing countries, it is a luxury. Water shortages and polluted water have become routine for millions of Venezuelans in the last two decades due to a failing economy and infrastructure mismanagement. According to the World Health Organization, arsenic (As) is a worldwide pollutant. Though it occurs naturally, As is toxic and may cause chronic poisoning with prolonged exposure. An estimated 4.5 million individuals in Latin America are chronically exposed to high levels of As (>50 𝜇g/L), some up to 2000 𝜇g/L. Biochar, a carbon-based material, effectively adsorbs and sequesters pollutants. …

A Gud Toolbox: Implementation Of Giving-Up Densities With Mammals, Brandon Preston, Jordan Tandy, Kundil Patel, Karissa Coffield

Scholars Week

Giving-up densities are the density of food remaining within an artificial foraging patch over a specified time and are an indicator of how an organism perceives its environment. The GUD method is particularly useful to study the foraging behavior of an organism relative to predation risk and interactions with other environmental variables (e.g., cover, conspecifics, and food quantity and quality) to address larger ecological and evolutionary questions. The GUD methodology is commonly used with the mammalian taxonomic group due to their general size, detectability, and abundance in comparison to other taxa. However, development of protocols that maximize the potential for …

Peruvian Fur Seals As Archivists Of El Niño Southern Oscillation Effects, Mickie Rae Edwards, Susana Cardenas-Alayza, Michael Adkesson, Mya Daniels-Abdulahad, Amy Hirons

Marine & Environmental Sciences Faculty Articles

Peru’s coastal waters are characterized by significant environmental fluctuation due to periodic El Niño- La Niña- Southern Oscillation (ENSO) events. This variability results in ecosystem-wide food web changes which are reflected in the tissues of the Peruvian fur seal (Arctocephalus australis). Stable isotope ratios (δ¹³C and δ¹⁵N) in Peruvian fur seal vibrissae (whiskers) are used to infer temporal primary production and dietary variations in individuals. Sea surface temperature anomaly (SSTA) recordings from the Niño 1+2 Index region captured corresponding ENSO conditions. Fluctuations in δ¹⁵N values were correlated to SSTA records, indicating that …

Which Outcomes Are Most Important To Measure In Patients With Covid-19 And How And When Should These Be Measured? Development Of An International Standard Set Of Outcomes Measures For Clinical Use In Patients With Covid-19: A Report Of The International Consortium For Health Outcomes Measurement (Ichom) Covid-19 Working Group, William H. Seligman, Luz Fialho, Nick Sillett, Christina Nielsen, Farhala Mari Baloch, Philip Collis, Ingel K M. Demedts, Marcelo P. Fleck, Maiara A. Floriani, Nasreen Muhammad

Section of Cardiology

Objectives: The COVID-19 pandemic has resulted in widespread morbidity and mortality with the consequences expected to be felt for many years. Significant variation exists in the care even of similar patients with COVID-19, including treatment practices within and between institutions. Outcome measures vary among clinical trials on the same therapies. Understanding which therapies are of most value is not possible unless consensus can be reached on which outcomes are most important to measure. Furthermore, consensus on the most important outcomes may enable patients to monitor and track their care, and may help providers to improve the care they offer through …

Crow's Nest, November 15, 2021, Crow's Nest Staff

Crow's Nest

The November 15, 2021, issue of the Crow's Nest.

Methodological Approaches To Measuring Amyloid Pet: A Scoping Review In Ethnoracial Minorities, Amy Nguyen, Stacey Moeller M.Sc, Samantha John

Undergraduate Research Symposium Posters

Alzheimer’s disease (AD) disproportionately affects Hispanic/Latinx (H/Lx) and Black/African American (B/AA) individuals, who face about 1.5-fold and 2-fold more risk of disease development, respectively, than non-Hispanic whites. Few studies examine AD biomarkers within ethnoracial minorities, especially for newer research techniques, such as Positron Emission Tomography (PET). This study reviews current literature on amyloid PET within H/Lx and B/AA populations, exploring methodological approaches.

A scoping review of AD literature was conducted to identify publications with H/Lx and B/AA study samples and amyloid PET data. Two researchers combined search results from three databases, deleted duplicates, and independently reviewed publication abstracts to determine …

The Potential Health Effects Of Bacterial Use In Self-Healing Concrete: A Systematic Literature Review, Brandon Polimeni, Moses Karakouzian Ph.D.

Undergraduate Research Symposium Posters

In due course, structures developed from concrete create microcracks exposing it to degradation via the reinforcement steel's formation of ferric oxide. The aforementioned declines the loading capacity and lessens durability. A corrective technique used to counteract the effects above is bio-mineralization, self-healing the crevices with microorganisms' metabolic processes. Literature has explored some specific organisms used, and the research strongly supports that the existing bacteria used positively strengthen the concrete's durability. This literature analysis examines if the selected microorganisms: Sporosarcina pasteurii, Lysinibacillus sphaericus, Bacillus cereus, and Bacillus subtilis used in some current constructional methods will harm the health of consumers or …

Defining Antisemitism, Mark Goldfeder

Seton Hall Law Review

No abstract provided.

An Employee Services Model: Morale And Satisfaction, David L. Groves, Bryan Cavins

Visions in Leisure and Business

The Raube manuscript was used as a secondary source to obtain a historical perspective about important factors that influence employees. Included in this assessment was a perspective from employees, management, and unions. This type of analysis is essential to understand the relationships between management and employees and be able to develop a model of collaboration and cooperation from both perspectives.

It is obvious that diverse factors are important during different time periods. It is essential though to understand the different time periods and their influences. This type of information will provide a longitudinal perspective and a better understanding of the …

Editorial: Perturbations In Metabolic Cues: Implications For Adverse Cardiac Function Leading To Sudden Cardiac Death, Brian P. Delisle, Ademuyiwa S. Aromolaran

Physiology Faculty Publications

No abstract provided.

Engineering Dean Inducted Into National Academy Of Inventors, Edwin B. Smith

University of Mississippi News

Organization recognizes academic innovation, technology

Artificial Intelligence: An Interprofessional Perspective On Implications For Geriatric Mental Health Research And Care, Brenna N. Renn, Matthew Schurr, Oleg Zaslavsky, Abhishek Pratap

Psychology Faculty Research

Artificial intelligence (AI) in healthcare aims to learn patterns in large multimodal datasets within and across individuals. These patterns may either improve understanding of current clinical status or predict a future outcome. AI holds the potential to revolutionize geriatric mental health care and research by supporting diagnosis, treatment, and clinical decision-making. However, much of this momentum is driven by data and computer scientists and engineers and runs the risk of being disconnected from pragmatic issues in clinical practice. This interprofessional perspective bridges the experiences of clinical scientists and data science. We provide a brief overview of AI with the main …

University Philharmonic Orchestra & University Band Program, Nancy Conley, Hannah Rudy

Bailey School of Music Concert Programs

Program for University Philharmonic Orchestra & University Band

Intersectionality, Relational Positionality, And The Lived Experiences Of Inequality: Contextualizing Intergenerational Opioid Use And The Constrained Choices Of Indigenous, Latina, And White Women Caregivers In Rural New Mexico, Carmela M. Roybal

Sociology ETDs

Opioid addiction is a serious and persistent global health issue. The federal Centers for Disease Control and Prevention (CDC) reported that between 1999 and 2016, more than 630,000 people in the United States died of an overdose of a prescription opioid or illicit drug (CDC 2018). Extant research has suggested that for nearly a century, New Mexico has experienced some of the highest rates of prescription and illicit opioid death in the nation (Goldstein and Herrera, 1995; Landon, 2003; Shah et al., 2008). I examined intergenerational opioid dependence through the lived experience of women caregivers of opioid-addicted family members. Data …

Declines Of Juvenile Coastal Cutthroat Trout And Coho Salmon Over Fifteen Years In A Salmon-Bearing Stream In The Salish Sea, Anne-Marie Flores, Morgan M. Davies, Katrina Kushneryk, Pippi T.E.S. Lawn, Sibylla Helms, Hanna M. Thomson, Kyle R. Nelson, Christopher W. Burns, Steven Roias, Travis G. Gerwing

Western North American Naturalist

Pacific salmon are ecologically, economically, and culturally important species indigenous to British Columbia, Canada. Unfortunately, some populations of Pacific salmon have been declining due to climate change, habitat loss, overfishing, and anthropogenic development. As such, considerable resources have been invested to study, restore, protect, and monitor Pacific salmon and their habitat. Since 2004, Lyall Creek, a salmon-bearing stream in the Salish Sea in British Columbia, Canada, has been monitored. Using 2-pass electrofishing, we investigated changes in observed densities over 15 years (2004–2019) for juvenile coho salmon (Oncorhynchus kisutch) and juvenile coastal cutthroat trout (Oncorhynchus clarkii clarkii) …

American Letters: Mencken, Editorial Board

The International Journal of Ecopsychology (IJE)

No abstract provided.

Anthropocentric Tautologies: The Ape Who Mistook His Jabbering For A Self, George Conesa

The International Journal of Ecopsychology (IJE)

No abstract provided.

Humans (Really) Are Animals: Picture-Book Reading Influences 5-Year-Old Urban Children’S Construal Of The Relation Between Humans And Non-Human Animals, Sandra Waxman, Patricia Herrmann, Jennifer Woodring, Douglas Medin

The International Journal of Ecopsychology (IJE)

What is the relation between humans and non-human animals? From a biological perspective, we view humans as one species among many, but in the fables and films we create for children, we often offer an anthropocentric perspective, imbuing non-human animals with human-like characteristics. What are the consequences of these distinctly different perspectives on children’s reasoning about the natural world? Some have argued that children universally begin with an anthropocentric perspective and that acquiring a biological perspective requires a basic conceptual change (Carey, 1985). But recent work reveals that this anthropocentric perspective, evidenced in urban 5-year-olds, is not evident in 3-year-olds …

Lanthorn, Vol. 56, No. 13, November 15, 2021, Grand Valley State University

Volume 56, August 2, 2021 - April 18, 2022

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

How Heritable Traits Of Parental Care Influence Brood Sex Ratio In The Carolina Wren (Thryothorus Ludovicianus), Ashley Juanita Atkins Coleman

Electronic Theses and Dissertations Archive

Rearing conditions have sex-specific effects on offspring which can influence the unequal production of sons and daughters according to environmental conditions. Particularly in species in which males a re larger and more expensive to produce. In such species, high-quality mothers are expected to over-repoduce sons. Such conditions arise in the Carolina wren, a species in which sexual size dimorphism manifests prior to independence and maternal fitness is influenced by environmental conditions, thereby favoring the unequal production of sons and daughters. However, high-quality daughters can have greater reproductive value than sons. Therefore, high-quality mothers might over-rpoduce daughters because daughters will inherit …

Lignin, Sugar, And Furan Production Of Industrial Hemp Biomass Via An Integrated Process, Jikai Zhao, Jason Griffin, Kraig Roozeboom, Juhee Lee, Donghai Wang

School of Earth, Environmental, & Marine Sciences Faculty Publications

Traditional pretreatment of lignocellulosic biomass is often accompanied by washing and disposal of wastewater, which leads to overuse of water and loss of by-products. The objectives of this study were to validate the potential of an acid-base integrated process for simultaneous sugars, furans, and lignin production without washing and wastewater discarding. The difference in conversion performance among different biomass resources was also demonstrated. Parallel acetic acid (HOAc, pH = 2.25) and sodium hydroxide (NaOH, pH = 13.46) pretreatments followed by solid and liquid integration were applied to four genotypes of industrial hemp (Cannabis sativa L.) biomass that were harvested …

Local And Systemic Cytokine, Chemokine, And Fgf Profile In Bacterial Chondronecrosis With Osteomyelitis (Bco)-Affected Broilers, Alison Ramser, Elizabeth Greene, Robert Wideman, Sami Dridi

Poultry Science Faculty Publications and Presentations

Complex disease states, like bacterial chondronecrosis with osteomyelitis (BCO), not only result in physiological symptoms, such as lameness, but also a complex systemic reaction involving immune and growth factor responses. For the modern broiler (meat-type) chickens, BCO is an animal welfare, production, and economic concern involving bacterial infection, inflammation, and bone attrition with a poorly defined etiology. It is, therefore, critical to define the key inflammatory and bone-related factors involved in BCO. In this study, the local bone and systemic blood profile of inflammatory modulators, cytokines, and chemokines was elucidated along with inflammasome and key FGF genes. BCO-affected bone showed …

Conflict, Extremism, Resilience And Peace In South Asia; Can Covid-19 Provide A Bridge For Peace And Rapprochement?, Zulfiqar Ahmed Bhutta, Arun Mitra, Afsah Salman, Fawad Akbari, Suraya Dalil, Fyezah Jehan, Mushtaque Chowdhury, Saroj Jayasinghe, Purnima Menon, Samiran Nundy

Institute for Global Health and Development

Abstract, issue, and pagination are not provided by the author/publisher

Metal Pollutant Pathways In Cohesive Coastal Catchments: Influence Of Flocculation And Biopolymers On Partitioning And Flux, R. J. Schindler, S. D.W. Comber, A. J. Manning

School of Geography, Earth and Environmental Sciences

No abstract provided.

Improving Search Engine Performance Through Dynamic Caching, C Gutierrez-Soto, Ma Palomino, E Roa, P Galdames

School of Engineering, Computing and Mathematics

No abstract provided.

Resource Allocation And Phenotypic Plasticity Of Simultaneous Hermaphroditic Turtle Barnacles (Chelonibia Testudinaria), Kevin C. Cash

All HCAS Student Capstones, Theses, and Dissertations

This research addresses the knowledge gap of phenotypic plasticity in a commonly found and important species of epizoic barnacle, Chelonibia testudinaria. Limited research has been published regarding how phenotypic expression is mediated the spatial distribution of barnacles on a mobile host. To investigate this potential relationship, barnacles were collected from the backs of turtles along the beaches of Fort Lauderdale Florida. These barnacles were assessed for various phenotypic traits as well as their corresponding spatial distribution on the turtle carapace. Barnacles were safely removed from the carapace using a chisel before their preservation in ethanol. Barnacles were then numbered …

Exploring The Geometric And Electronic Properties Of Palladium Doped Silicon Clusters, Madison Winkeler, Ciara N. Richardson

Scholars Week

Transition metal-doped silicon clusters have unique properties and have been studied as building blocks for nanomaterials and microelectronics. Here, the structure and properties of candidate palladium doped silicon clusters (SinPd2: n=1-17) were determined using global optimization techniques on a high performance computing cluster at the San Diego Supercomputing Center. Then geometric structures were further optimized utilizing the B3LYP method with 6-311+G(d) basis sets for silicon and lanl2dz pseudopotential for palladium, followed by the larger DSDPBEP86 method with 6-311+G(2d) basis sets for silicon and SDD pseudopotential for palladium, as implemented in the Gaussian 16 program package. The energetics for each cluster …