Digital Commons Network^™

Computational Design Of Β-Fluorinated Morphine Derivatives For Ph-Specific Binding, Makena Augenstein, Nayiri Alexander, Matthew Gartner

Student Scholar Symposium Abstracts and Posters

Molecular extension and dissection techniques are used to design a morphine derivative that promotes selective binding in inflamed tissue due to its lower pH while avoiding dangerous activation in the brain. Morphine is used to treat pain associated with inflammation. While being effective analgesics, opioids carry the risk of central side effects, including addiction, respiratory depression, and sedation. Opioids are agonists that bind to the μ-opioid peptide receptor (MOR) within central and peripheral nerves and act via a G-protein coupled receptor pathway.

Deprotonation of the tertiary amine induces a negative charge on the nitrogen, discouraging binding at physiological pH (pH=7.4). …

Development Of Comprehensive Theoretical Morphospaces For Canine Cranial Morphology, Alexa Ortega, Nicholas Hebdon, Lindsay Waldrop

Student Scholar Symposium Abstracts and Posters

Throughout the evolution of the family Canidae, there is a continuous belief that canines have an exceptional olfactory system which allows them to have a heightened sense of smell. Because of this olfactory sophistication, canines have become prevalent as detection animals in the military, homeland security, law enforcement, forensics, and civilian applications. However, while the trait is highly regarded, the exact role of nasal morphology is understudied. We aim to investigate the influences of nasal cavity and internal structure morphology in odor detection. However, nasal structure is a sophisticated morphological target and requires innovative solutions to capture the key variables …

Thinkmed: Providing An Environment For Disadvantaged Students To Explore Stem, Steven Trinh, Lauren Dudley, Peter Chang

Student Scholar Symposium Abstracts and Posters

ThinkMED is a nonprofit initiative offering a four-week curriculum specifically designed to develop critical thinking and encourage evidence-based decision making. Each week’s content material revolves around the use of a ThinkMED Science Kit containing a wet lab experiment designed to supplement the content curriculum. Each experiment is formulated to be inclusive of all California Next Generation Science Standards K through 5. Contained within each week’s ThinkMED Science Kit is a unique QR code that directs the student to an interactive simulation of the experiment created by our team of computer scientists and graphic designers. At the end of each week, …

Fall 2021 Student Scholar Symposium Abstract Volume, Chapman University Center For Undergraduate Excellence

Student Scholar Symposium Abstracts and Posters

No abstract provided.

Unmet Needs In Adolescents And Young Adults With Cancer: A Mixed-Method Study Using Social Media, Eunju Choi

Sigma Foundation for Nursing Research Grant Reports

The purpose of this study is to identify and compare the unmet needs of adolescents and young adults (AYAs) with cancer by age and gender.

Limitations Of Available Blood Products For Massive Transfusion During Mass Casualty Events At Us Level 1 Trauma Centers, James Williams, Michael Gustafson, Yu Bai, Samuel Prater, Charles E Wade, Oscar D Guillamondegui, Mansoor Khan, Megan Brenner, Paula Ferrada, Derek Roberts, Tal Horer, David Kauvar, Andrew Kirkpatrick, Carlos Ordonez, Bruno Perreira, Artai Priouzram, Juan Duchesne, Bryan A Cotton

Faculty, Staff and Student Publications

INTRODUCTION: Exsanguination remains a leading cause of preventable death in traumatically injured patients. To better treat hemorrhagic shock, hospitals have adopted massive transfusion protocols (MTPs) which accelerate the delivery of blood products to patients. There has been an increase in mass casualty events (MCE) worldwide over the past two decades. These events can overwhelm a responding hospital's supply of blood products. Using a computerized model, this study investigated the ability of US trauma centers (TCs) to meet the blood product requirements of MCEs.

METHODS: Cross-sectional survey data of on-hand blood products were collected from 16 US level-1 TCs. A discrete …

Runs Of Homozygosity In Killer Whale Genomes Provide A Global Record Of Demographic Histories, Andrew D. Foote, Rebecca Hooper, Alana Alexander, Robin W. Baird, Charles Scott Baker, Lisa Ballance, Jay Barlow, Andrew Brownlow, Tim Collins, Rochelle Constantine, Luciano Dalla Rosa, Nicholas J. Davison, John W. Durban, Ruth Esteban, Laurent Excoffier, Sarah L.Fordyce Martin, Karin A. Forney, For Full Author List, See Comments Below

Faculty Research, Scholarly, and Creative Activity

Runs of homozygosity (ROH) occur when offspring inherit haplotypes that are identical by descent from each parent. Length distributions of ROH are informative about population history; specifically, the probability of inbreeding mediated by mating system and/or population demography. Here, we investigated whether variation in killer whale (Orcinus orca) demographic history is reflected in genome-wide heterozygosity and ROH length distributions, using a global data set of 26 genomes representative of geographic and ecotypic variation in this species, and two F1 admixed individuals with Pacific-Atlantic parentage. We first reconstructed demographic history for each population as changes in effective population size through time …

Eye-Transcriptome And Genome-Wide Sequencing For Scolecophidia: Implications For Inferring The Visual System Of The Ancestral Snake, David J. Gower, James F. Fleming, Davide Pisani, Freek J. Vonk, Harald M.I. Kerkkamp, Leo Peichl, Sonja Meimann, Nicholas R. Casewell, Christiaan V. Henkel, Michael K. Richardson, Kate L. Sanders, Bruno F. Simões

More Faculty of Science and Engineering Research

Molecular genetic data have recently been incorporated in attempts to reconstruct the ecology of the ancestral snake, though this has been limited by a paucity of data for one of the two main extant snake taxa, the highly fossorial Scolecophidia. Here we present and analyze vision genes from the first eye-transcriptomic and genome-wide data for Scolecophidia, for Anilios bicolor, and A. bituberculatus, respectively. We also present immunohistochemistry data for retinal anatomy and visual opsin-gene expression in Anilios. Analyzed in the context of 19 lepidosaurian genomes and 12 eye transcriptomes, the new genome-wide and transcriptomic data provide evidence for a much …

Current Status And Natural History Of The Critically Endangered Variable Harlequin Toad (Atelopus Varius) In Costa Rica, C Barrio-Amorós, G Chaves, R Puschendorf

School of Biological and Marine Sciences

No abstract provided.

Economic Forecasting In An Epidemic: A Break From The Past?, Hwee Kwan Chow, Keen Meng Choy

Research Collection School Of Economics

This paper aims to investigate whether the predictive ability and behaviour of professional forecasters are different during the Covid-19 epidemic as compared with the global financial crisis of 2008 and normal times. To this end, we utilise a survey of professional forecasters in Singapore collated by the central bank to analyse the forecasting record for GDP growth and CPI inflation. We first examine the point forecasts to document the extent of forecast failure in the pandemic crisis and test for behavioural explanations of the possible sources of forecast errors such as leader following and herding behaviour. Using percentile-based summary measures …

Modeling The Spatial Distribution Of The Current And Future Ecosystem Services Of Urban Tree Planting In Chicopee And Fall River, Massachusetts, R. Moody, N. Geron, M. Healy, J. Rogan, Deborah Martin

Geography

Mature urban tree canopy cover disrupts the local effects of urban heat islands and provides important ecosystem services such as energy savings through evaporation and shading, pollution removal, storm runoff control, and carbon sequestration. Sustainable urban tree canopy relies on the planting of juvenile trees. Typically, tree planting programs are only evaluated by the number of trees planted and there is a lack of analysis of juvenile trees post-planting. This study examines the value and distribution of energy savings provided by juvenile trees and how that value changes considering predicted tree growth and mortality by 2050. Using i-Tree Eco software, …

Nest Sanitation Behavior Does Not Increase The Likelihood Of Parasitic Egg Rejection In Herring Gulls, James B. Stratton, Donald C. Dearborn

All Faculty Scholarship

Birds’ behavioral response to brood parasitism can be influenced not only by evolution but also by context and individual experience. This could include nest sanitation, in which birds remove debris from their nests. Ultimately, nest sanitation behavior might be an evolutionary precursor to the rejection of parasitic eggs. Proximately, the context or experience of performing nest sanitation behavior might increase the detection or prime the removal of parasitic eggs, but evidence to date is limited. We tested incubation-stage nests of herring gulls Larus argentatus to ask whether nest sanitation increased parasitic egg rejection. In an initial set of 160 single-object …

School District Leadership And Racial Justice: Examining The Use Of A Culturally Responsive-Sustaining Framework To Advance Equity Between Black And White Student Populations Within New York State Public Education, Diane M. Wynne

Education Doctoral

The current climate in the United States reflects a heightened focus on examining and challenging systemic inequities that have long impacted Black individuals. Culturally responsive education efforts have increased as schools experience increasingly diverse populations. The purpose of this study was to gain an understanding of how district leaders are implementing the New York State Education Department (NYSED) Culturally Responsive-Sustaining (CR-S) Education Framework in advancing equity between their Black and White student populations. Challenges and barriers experienced in the implementation of this framework, and approaches and strategies needed to overcome these were also explored. Interviews with six school district leaders …

Mathematical Modelling Of Gene Regulatory Networks, Ruaa Rifaat Al-Shykhly, Lamyaa Mohammed Hameed

Journal of Economics and Administrative Sciences

This research includes the use of an artificial intelligence algorithm, which is one of the algorithms of biological systems which is the algorithm of genetic regulatory networks (GRNs), which is a dynamic system for a group of variables representing space within time. To construct this biological system, we use (ODEs) and to analyze the stationarity of the model we use Euler's method. And through the factors that affect the process of gene expression in terms of inhibition and activation of the transcription process on DNA, we will use TF transcription factors. The current research aims to use the latest methods …

An Assessment Of The Neurovascular Structures Of The Trigeminal Nerve And Their Relationship To Diet In Primates, Caitlin Yoakum

Graduate Theses and Dissertations

The inferior alveolar nerve (IAN) enters the mandible via the mental foramen, supplies nervous sensation to the mandibular teeth as it travels through the mandibular canal, and exits the mandibular foramen to send information to the brain to maintain chewing cycles and protect the teeth from damage. Although bony canals and foramina have been shown to form around soft-tissue structures, there are some examples (e.g., the hypoglossal nerve/canal) where the nervous structures do not comprise most of the canal/foramina space. It is important to know the size of nerves because it has been established that larger nerves convey more information …

Canine Microwear In Relation To Diet In Sumatran Primates And African Great Apes, Putu Pujiantari

Graduate Theses and Dissertations

This thesis considers canine microwear in relation to diet in five Sumatran primates (Pongo abelii, Hylobates lar, Hylobates agilis, Presbytis thomasi, and Macaca fascicularis) and two African great apes (Pan paniscus and Pan troglodytes schweinfurthii) using both microwear texture analysis and microwear feature analysis techniques. Statistical results for texture analysis show that there are significant differences in scale of maximum and heterogeneity. This indicates that some species have large pits on their canine surfaces, having these dominated by deep features at coarse scale yet have a slight microwear heterogeneity. For feature analysis, all variables show statistically significant variation. Variance in …

The Relationship Of Hospital Ceo Gender And The Patient Experience: The Role Of The Mediating Effects Of Hospital Characteristics, Lanean M. Lang

Electronic Theses and Dissertations

In this quantitative study, I investigated CEO gender and the patient experience in acute care hospitals in Texas for 2019. As the patient-experience has been the metric for quality patient care and hospital reimbursements, hospital CEOs play an important role in promoting positive patient experience as they lead the organization in strategic goals. The study is relevant as a shortage of experienced and qualified healthcare leaders is expected as baby-boomers retire. The lack of women leaders remains a challenging issue. The purpose of the study was to assess the gender differences of the CEO on the impact of patient experience …

Agents Of Bioshield: The Fda, Emergency Use Authorizations, And Public Trust, Kirstiana Perryman

Georgia Law Review

The SARS-CoV-2 pandemic spurred the U.S. Food & Drug Administration (FDA) to utilize the Emergency Use Authorization (EUA) procedure more than ever before. The pandemic pushed the relatively obscure procedure into public consciousness, making it a frequent topic of discussion and debate. The EUA procedure permits the FDA Commissioner to authorize the introduction of drugs, devices, or biological products into interstate commerce for use in an actual or potential emergency. To issue an authorization, the FDA Commissioner must determine that it is “reasonable to believe,” based on the “totality of the evidence,” that the product “may be effective.” This standard …

Mechanisms And Applications Of Improved Protein Analysis By Desorption Electrospray Ionization Mass Spectrometry (Desi-Ms), Roshan Javanshad

Dissertations

Electrospray ionization mass spectrometry (ESI-MS) is a soft ionization technique that allows detection of macromolecules, such as intact proteins, by the formation of multiply charged ions from solutions. Desorption electrospray ionization mass spectrometry (DESI-MS) is an ambient ionization technique that directly samples analyte from a surface during ESI-MS analysis. Although DESI-MS is highly accomplished at the analyses of metabolites, lipids, and other small molecules, it is far more limited when it comes to protein analysis. While most of the field in ambient ionization MS has moved towards primarily applications, our approach has been to explore the use of DESI-MS and …

Advanced Risk Models To Predict Surgical Site Infections Using Machine Learning Approaches And Risk-Adjusted Control Charts, Rabia Emhamed Al Mamlook

Dissertations

Even though most infections are treatable with antibiotics, Surgical Site Infections (SSIs) remain a significant healthcare problem as they increase hospital stays, require additional treatments, reduce a patient’s quality of life, and increase morbidity and mortality. To reduce the risks and to encourage the highest quality healthcare, it is important to measure, predict, and monitor the risk of SSIs. Preoperative prediction of SSIs is essential to facilitate the implementation of preventative strategies for high-risk patients. The overarching goal of this dissertation is to investigate new opportunities of using machine-learning (ML) to improve the accuracy and use of pre-operative prediction models …

Relation Between Epithelial-Mesenchymal Transition And Colorectal Cancer Prognosis: Impact Of Smad4 And Β-Catenin Markers, Mona Emile, Dina Ibrahim, Amr El-Karef, Ibrahim Eldosoky, Mohammed Awad

Mansoura Medical Journal

Colorectal cancer (CRC) is one of the most prevalent and deadly neoplasms. It develops through several molecular pathways and varies in clinical presentation and patient prognosis. The prognosis of CRC is influenced by variable pathologic and molecular variables. Understanding the molecular basis that promote CRC progression, invasive and metastatic features, is important for establishing effective CRC therapeutic strategies. Epithelial mesenchymal transition (EMT) is regarded to be key hallmark of CRC carcinogenesis, providing metastatic capacities to cancer cells by promoting motility and invasion. During this process, epithelial markers such as E-cadherin are down-regulated, whereas mesenchymal markers such as Vimentin are up-regulated. …

Clinical Scoring For Early Detection Of Prediabetes In Egyptian Population, Ahmed Abdel-Hamid, Enas Elkhamisy, Megahed Abo Elmagd

Mansoura Medical Journal

Background: Prediabetes is a wide spread condition where blood glucose is above normal, but it does not measure up to the criteria of diabetes mellitus. Yet there is no national scoring system for prediabetes according to the potential risk factors. Methods: A case-control study has been carried out in Mansoura Specialized Hospital. Subjects have been recruited from out-patients clinic in the period from October 2018 to August 2019. Those with prediabetes had been assigned to be the case group whereas control subjects were those who had a normal HbA1C. A scoring system was based on risk factors of prediabetes by …

Non-Resectional Procedures As Treatment Options For Hemorrhoidal Disease., Esraa Daif, Hossam Elfeki, Ashraf Shoma

Mansoura Medical Journal

Hemorrhoids have been recorded through hundreds of years of history. It is a very common condition affecting millions of people around the world every year with an estimated prevalence of 4.4% of the population in the United States. Hemorrhoids are defined as the pathological enlargement and downward displacement of the anal cushions. The risk factors of this condition include a low-fiber diet, constipation, and prolonged straining. It is clinically manifested by painless bleeding with the bowel movement with or without prolapse. Other symptoms like pain or pruritus that affect the patients’ quality of life. Hemorrhoids can be managed by multiple …

Reconstruction Of Glossectomy Defects Post Oncologic Resection, Sara Elbaz, Shadi Awny, Ashraf Shoma

Mansoura Medical Journal

The tongue is a muscular organ completely covered by mucous membrane and made up of two portions divided by the V-shaped sulcus terminalis: an anterior 2/3 (oral tongue) and a posterior 1/3 (tongue base). The tongue is essential to normal speech as well as swallowing process, and healthy tongue function is vital within the general quality of life. Tongue cancers are aggressive tumors with poor prognosis, so the early detection markedly raises the possibility of cure with minimal impairment and deformity. Management needs a surgical, medical and radiation oncologist in association with speech therapist, physical rehabilitation, and psychologists. In addition …

2021 December, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for December of 2021.

Youth Mental Health Service Preferences And Utilization Patterns Among Latinx Caregivers, Alejandro L. Vázquez, María De La Caridad Alvarez, Cynthia M. Navarro Flores, José Manuel González Vera, Tyson S. Barrett, Melanie M. Domenech Rodríguez

Psychology Faculty Publications

Latinx caregivers underutilize traditional youth mental health services (MHS) relative to their White counterparts. Disparities may be explained by barriers preventing engagement in traditional MHS. A potential mismatch between available services and preferred culturally appropriate healing practices may also contribute to treatment disparities. The current study examined Latinx caregivers’ perceived need for and utilization of support services in relation to family characteristics, youth problem-type, and barriers to care. Findings were contextualized by assessing caregiver preferences for addressing youth psychopathology. The study consisted of 598 Latinx caregivers from across the United States. Descriptive statistics and binary logistic regression models were used …

Identification And Characterization Of Bisbenzimide Compounds That Inhibit Human Cytomegalovirus Replication, Nicole Falci Finardi, Hyeongjun Kim, Lee Z. Hernandez, Matthew R. G. Russell, Catherine M-K Ho, Vattipally B. Sreenu, Hannah A. Wenham, Andy Merritt, Blair L. Strang

Physics & Astronomy Faculty Publications

The shortcomings of current anti-human cytomegalovirus (HCMV) drugs has stimulated a search for anti-HCMV compounds with novel targets. We screened collections of bioactive compounds and identified a range of compounds with the potential to inhibit HCMV replication. Of these compounds, we selected bisbenzimide compound RO-90-7501 for further study. We generated analogues of RO-90-7501 and found that one compound, MRT00210423, had increased anti-HCMV activity compared to RO-90-7501. Using a combination of compound analogues, microscopy and biochemical assays we found RO-90-7501 and MRT00210423 interacted with DNA. In single molecule microscopy experiments we found RO-90-7501, but not MRT00210423, was able to compact DNA, …

Open Education Resources And The Academic Library, Jeanette A. Parker

The Christian Librarian

Librarians have an opportunity to assist faculty and students in adoption and use of OER, or Open Educational Resources. Faculty and students present differing perspectives and responses to OER that may inhibit their use. Libraries are known for providing access to resources and educational training or workshops on the use of new technologies and existing or new resources. Libraries are also accustomed to providing proxied access to online resources, hosting repositories and developing policies for management, curation and collection of a wide array of materials and resources. By helping to develop and organize an OER initiative of any kind at …

Effects Of Localized Oxygen Production By Electrolysis On The First-Generation Glucose Sensor Response, Nandita Halder

Graduate Theses and Dissertations

Glucose sensors are very important for detecting blood glucose both in vitro and in vivo. First-generation glucose biosensors were based on the glucose oxidase (GOx) enzyme using molecular oxygen as the electron acceptor and therefore oxygen dependent. Unfortunately for in-vivo work, oxygen in the body is variable and limited. Alternative approaches to overcome the oxygen dependency came with their own limitations. The widely used and commercially available ex-vivo glucose test strip uses a mediator in place of oxygen to free it from oxygen dependency. The mediator-based technology, in most cases cannot be transferred to in vivo applications due to the …

Substance Use And Psychological Distress Correlates Of Sleep Quality Among College Students, Juanybeth Morales Ortega

Graduate Theses and Dissertations

Poor sleep quality in college students is a major problem associated with adverse health outcomes, cognitive performance, substance use, and psychological distress. Our study explored how substance use and psychological distress are associated with the sleep quality of college students. We analyzed secondary data collected in 2019 using a cross-sectional survey design. Measures included participants’ demographic characteristics, sleep quality using the Pittsburg Sleep Quality Index (PSQI), drug use, depression using the Patient Health Questionnaire-9 (PHQ-9), and suicidality. After excluding participants with missing information for sleep quality, a total of 555 students remained for the analysis. Our bivariate analysis found that …