Digital Commons Network^™

Mitochondrial Aberrations During The Progression Of Disuse Atrophy Differentially Affect Male And Female Mice, Megan E. Rosa-Caldwell, Seongkyun Lim, Wesley S. Haynie, Jacob L. Brown, David E. Lee, Kirsten R. Dunlap, Lisa T. Jansen, Tyrone A. Washington, Michael P. Wiggs, Nicholas P. Greene

Health, Human Performance and Recreation Faculty Publications and Presentations

Background

Disuse decreases muscle size and is predictive of mortality across multiple pathologies. Detriments to mitochondrial function are hypothesized to underlie disuse-induced muscle atrophy. Little data exist on early mechanisms contributing to onset of these pathologies, nor is it known how they differ between sexes. The purpose of this study was to examine differential and conserved responses to mitochondrial quality control in male and female mice during the development and progression of disuse-induced atrophy.

Methods

One hundred C57BL/6J mice (50 male and 50 female) were hindlimb unloaded to induce disuse atrophy for 0 (con), 24, 48, 72, or 168 h. …

Applying Behavioral And Physiological Measures To Assess The Relative Impact Of The Prolonged Covid-19 Pandemic Closure On Two Mammal Species At The Oregon Zoo: Cheetah (A. Jubatus) And Giraffe (G. C. Reticulata And G. C. Tippelskirchii), Laurel Fink, Candace D. Scarlata, Becca Vanbeek, Todd Bodner, Nadja C. Wielebnowski

Biology Faculty Publications and Presentations

The effect of visitor presence on zoo animals has been explored in numerous studies over the past two decades. However, the opportunities for observations without visitors have been very limited at most institutions. In 2020, the Oregon Zoo was closed, in response to the global SARSCoV-2 (COVID-19) pandemic, from 15 March 2020 to 12 July 2020, resulting in approximately four consecutive months without visitor presence. This study aimed to quantify potential behavioral and hormonal changes expressed during two transition periods in zoo visitor attendance: the initial time period before and after closure in March 2020 and time before and after …

A Proposed Mechanism For Financial Reporting On Sustainable Investment And Its Role In Achieving Value Added - Applied In The Iraqi Midland Refineries Company-, Mohammed Ataallah Ali, Salman Hussin Abdullah

Journal of Economics and Administrative Sciences

The research aims to develop a proposed mechanism for financial reporting on sustainable investment that takes the specificity of these investments. To achieve this goal, the researcher used (what if scenario) where the future financial statements were prepared for the year 2026, after completion of the sustainable project and operation, as the project requires four years to be completed. The researcher relied on the results of the researchers collected from various modern sources relevant to the research topic and published on the internet, and the financial data and information obtained to assess the reality of the company's activity and its …

Sigesn Light-Emitting Devices: From Optical To Electrical Injection, Yiyin Zhou

Graduate Theses and Dissertations

Si photonics is a fast-developing technology that impacts many applications such as data centers, 5G, Lidar, and biological/chemical sensing. One of the merits of Si photonics is to integrate electronic and photonic components on a single chip to form a complex functional system that features compact, low-cost, high-performance, and reliability. Among all building blocks, the monolithic integration of lasers on Si encountered substantial challenges. Si and Ge, conventional epitaxial material on Si, are incompetent for light emission due to the indirect bandgap. The current solution compromises the hybrid integration of III-V lasers, which requires growing on separate smaller size substrates …

English-To-Ipa Transcription, Riley Roberts

Undergraduate Honors Capstone Projects

The purpose of this project was to create a tool that could automate English-to-IPA (International Phonetic Alphabet) transcription. Research was done to determine what would be required to perform such a transcription. After researching and experimenting with existing tools, it was determined that developing the signal processing and Artificial Intelligence model portion of the application would be too intensive to successfully complete within the timeframe of this project.

The choice was made to develop an iOS application, with the Python library Allosaurus used to do the speech processing and as the Artificial Intelligence model. This model was then deployed in …

Exploring The Relationship Between Trauma, Motivation, Current Stress, And Immigrant Elementary Students, Jayme Branagh Landon

Doctoral Dissertations and Projects

The current study explored the relationship between past trauma of immigrant students and motivation in a group of public-school elementary students in Washington state. Additionally, this study explored how stress affects academic motivation. It was hypothesized that past trauma would significantly affect immigrant student motivation and that current stress would moderate motivation in school. Only students with past trauma experience and who qualify as an immigrant, were included in this study. Participants completed The Cameron Complex Trauma Interview (CCTI), Motivated Strategies for Learning Questionnaire (MSLQ), and The Perceived Stress Scale for Children (PSS-C). While motivation has been studied, the factors …

Implementing Christlike Love In The Johnson Grove Baptist Church, Robert Lee Sullivan Jr.

Doctoral Dissertations and Projects

This research project was paramount, the title expressed the vision and purpose of the researcher as an under-shepherd of Christ. Implementing Christlike Love was not just designed for this church, but the key principle that was used in this project can inspire others. The problem addressed was a lack of true Christlike love in this church. Believers assumed that loving others would be automatic but loving like Christ requires God’s help. The purpose of this project was to appraise and resolve the perceived lack of Christlike love within the Johnson Grove Baptist Church. This researcher sought to provide a remedy …

Improving Students' Scores On The Georgia End Of Course Assessment For Biology, Natasha Takia Simpson

Doctoral Dissertations and Projects

The purpose of this applied study is to solve the problem of underperforming student test scores on the End of Course Biology assessment for high school students at an alternative school in Georgia, and to formulate a solution to address the problem. A multi-method design will be used consisting of both qualitative and quantitative approaches. The first approach will be structured interviews with the administration. The second approach will be focus groups with teachers. The third approach will analyze quantitative data from student surveys. The results may provide insight into an underlying problem in underperforming scores on the End of …

The Effectiveness Of Faith-Based Group Life Coaching On Stress And Anxiety Levels In Spouses Of Veterans With Post-Traumatic Stress Disorder, Esperanza Pilar Guerra Lugo

Doctoral Dissertations and Projects

Veterans who courageously served in the military are often diagnosed with post-traumatic stress disorder and their spouses are at high risk of suffering in silence from stress and anxiety. Many spouses are also their Veteran’s caregiver which leaves little time for their own self-care needs. Being a Veteran’s 24-hour caregiver can lead to poor physical and mental health, aggravating spouses stress and anxiety levels which is often only treated with medication or goes untreated due to lack of mental health care access and the stigma that comes with it. The literature review explores the research gap of how online faith-based …

Premarital Counseling As Foundational To Discipleship, David J. Hollifield

Doctoral Dissertations and Projects

This paper will examine the lasting impact of biblical, pastoral premarital counseling. Couples who have completed this type of program before marriage will be studied. This work will attempt to measure the impact of premarital counseling based on whether couples have used tools explored in their original counseling program in areas such as effective communication, conflict resolution, stewardship of money, and spiritual disciplines. If the tools and resources provided in counseling have never been utilized, this survey will seek to discover reasons the material was never used. The purpose of this study is to determine which areas are most helpful …

Bullying Victimization In Middle Schools: A Quantitative Correlational Study, Corey Centwane Calhoun Sr.

Doctoral Dissertations and Projects

Bullying victimization is a very common, complex and potentially damaging form of violence among children and adolescents. Bullying is defined as unwanted, aggressive behavior, which involves a real or perceived social power imbalance. The behavior is repeated, or has the potential to be repeated, over time (therefore, the definition excludes occasional or minor incidents). Bullying victimization in schools is not only alarming, but it has now become a persuasive concern, one that should be evaluated closely by educators, parents, and policymakers in all school systems. In public schools, 1 in 10 reports at least a case of serious violent crime, …

The Moderating Effect Of Shame Proneness On Avoidant God Attachment And On Anxious God Attachment, Tamika Andrews Sirmons

Doctoral Dissertations and Projects

This study’s focus was on examining both anxious and avoidant God attachment and the correlation of each to both positive and negative religious coping as moderated by shame proneness. Participants were 158 individuals ages 18 to 70 years across the United States who proclaim Christianity. They were assessed on their attachment relationship with God, religious coping strategies, and proneness to shame. Correlation analysis already established the relationship between God attachment and religious coping. Regression analysis revealed shame proneness as a moderator of the relationship between the two attachment styles and both positive and negative religious coping. This study had limitations …

Assessing The Views Of Haitian Evangelical Leaders Regarding Christ-Centered Preaching From The Old Testament, Stevenson Dorcélus-Cetoute

Doctoral Dissertations and Projects

Preaching is an absolute necessity, great preaching more so to transform society and advance God’s kingdom. Great preaching is that what points to Christ in every text from Scripture New Testament as well as Old Testament. Based on Luke 24 and other fundamental texts this study shows preaching Christ from the Old Testament is warranted. The purpose of the study however was to find out the attitude of Haitian leaders/pastors/preachers regarding Christocentric preaching and also ascertain if they are willing to know more whatever their knowledge is currently on the issue. This quantitative study uses the survey method, and we …

Copd Discharge Care Bundles: An Integrative Review, Leigh Goodwin Wingo

Doctoral Dissertations and Projects

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death in the United States. It is the reason for millions of emergency room and hospitalizations, increasing healthcare costs, morbidity, and mortality. Many studies have evaluated the effects of COPD patient care bundles to help reduce the risk of 30-60-90-day readmissions post discharge from the hospital for COPD exacerbation. A comprehensive search was conducted on articles dated between February 2015 to January 2020 in the MEDLINE, EMBASE, and CINAHL, OVID, internet search, and Liberty University online library. This review included articles based on the effectiveness of COPD discharge …

In Vitro Investigation Of Tumor Selective Piperidones As Therapeutic Agents Against Leukemia Cancer Cells, Lisett Contreras

Open Access Theses & Dissertations

Cancer is a continuous global health issue. It is the second leading cause of death behind heart disease. Disparities across the emergence of cancer and resulting fatalities raise the importance of researching the disease. Treatments are available for certain types of cancers. However, these are typically accompanied by residual problems including side effects and the possibility for relapse. Some treatments attack all cells, leading to unwarranted side effects that make the possibility of living a comfortable life nearly impossible. Other treatments are specific to certain genetic alterations, making them only useful for a small percentage of patients. Not one treatment …

Effects Of Coated/Uncoated Copper-Based Nanoparticles And Compounds On Rice (Oryza Sativa) And Soybean (Glycine Max) Plants, Chaoyi Deng

Open Access Theses & Dissertations

Engineering nanoparticles (ENPs) have been widely used in industry due to their promising chemical, physical, electrical, magnetic, optical, and electronic properties. Copper-based ENPs are used as gas sensors, catalysts, semiconductors and agricultural products, among others. Because of their antifungal and antibacterial properties, they are used in agriculture as insecticides, herbicides and antifungal agents. Due to their mass production and use, ENPs are likely to be ubiquitous in our in the environment in the near future. In addition, metal nanoparticles are usually coated with organic compounds to enhance the properties of the nanoparticles. Previous studies have shown that copper-based ENPs can …

Interval Constraint-Solving Strategies For Solving Dynamical Systems, Angel Fernando Garcia Contreras

Open Access Theses & Dissertations

There are abundant phenomena that humans can describe through mathematical models. Dynamical systems are one such type of model, describing the behavior of phenomena that change over time. For example, a scientist can measure and analyze an insect's wing parameters and movements to create a dynamical system of that behavior. We can then use this model in different applications, such as creating a nano vehicle with insect-like propulsion.

For many real life problems, there exist analytical solutions. These can represent a full description of the state of a dynamical system at any moment in continuous time. However, in most practical …

Combination Of Nir Triggered Lanthanide Upconverting Nanoplatforms With Fullerene For Controlled Drug Release And Photo Cancer Therapy, Lei Ma

Open Access Theses & Dissertations

Photodynamic therapy (PDT) is an emerging, externally activatable, treatment modality for various diseases, especially for cancer therapy. Similar to radiotherapy, the mode of action with PDT involves the use of electromagnetic radiation to generate radical species in situ. However, PDT is a much milder approach for cancer treatment. Because of the unique physicochemical properties of fullerenes (such as C60), many potential biomedical applications, including PDT, became possible with them. As a main principle of PDT, the anticancer properties of various fullerene preparations usually result from their ability to generate cytotoxic reactive oxygen species (ROS), after photoexcitation. However, because of the …

Evaluation Of Varying Graphene Oxides Through Their Physicochemical Characterizations On Erythrocytes, Hs27 Cells, Escherichia Coli And Staphylococcus Aureus Bacteria Cell Lines, To Assess Graphene Oxides Cytotoxicity., Miriam Montana

Open Access Theses & Dissertations

Research on the toxicity of Graphene Oxides (GO) has captivated interest in the field of material science, environmental sciences, and medicine for their avail significance in biomedical engineer applications either as integrates, enhancements, or in the making of medical devices. Moreover, there is still a lack of understanding as to what characteristics on GOs causes them to be cytotoxic at a cellular level. In our study we synthesized four different GOs by varying in both the method used for oxidation (Modified Hummer’s method & Improved Marcano-Tour’s method), and the precursor parent graphite, for a standardization approach to aid in the …

Transgenerational Differences Between Two Culturally Distinct Prairie Vole Populations, Richard Joaquin Ortiz

Open Access Theses & Dissertations

Culture can be described as a system of environmental beliefs, values, and social practices within one’s environment. This system is passed on from generation to generation and provides a basis for an individual’s behaviors and cognitive perceptions. Cultural neuroscience is an emerging field that intertwines domains of anthropology, psychology, neuroscience, and genetics to help understand the underlying processes, neural mechanisms and genomic factors that vary across cultures. Similar to humans, the socially monogamous prairie vole (Microtus ochrogaster) display populational differences in prosocial behavior and aggression based upon region-specific cultural upbringing and parental lineage. Prairie voles originating from Kansas (KS) display …

Building Energy Model Simulation Of A Single Building In Comparison To A Broader Building Stock, Paola Michelle Santillano

Open Access Theses & Dissertations

Residential facilities and buildings are the largest consumers of energy in the United States. More than 76% of electricity and more than 40% of all energy consumption comes from providing a comfortable and healthy environment in buildings. Prioritizing building energy technology goals for performance and cost can significantly reduce energy use within the next ten years despite a substantial forecasted population increase. Retrofitting existing buildings and improving future construction has the potential to realize cost savings and environmental benefits over time. A key component to realizing these benefits is regional building energy modeling. One of the challenges to widespread building …

Comprehensive Study Of Human Pathogenic Trypanosomatids: From Chemotherapies To Disease Ecology, Felipe Rodriguez

Open Access Theses & Dissertations

The vector-borne diseases Leishmaniasis and Chagas disease, caused by the kinetoplastid parasites Leishmania spp. and Trypanosoma cruzi respectively, are among the most important parasitic diseases in the group of neglected tropical diseases. Even though the two diseases are endemic to the Americas, they affect millions of people worldwide. Leishmaniasis and Chagas disease cause a great array of symptoms and some of them can be fatal if left undiagnosed and untreated. Current treatment regimens are becoming less effective, vaccines are still not available, and diagnosis needs to be improved. Vector control has been responsible for a decrease of diseases in endemic …

Long-Term Effects Of Adolescent Fluoxetine Exposure On Hippocampal Gene Expression In Male C57bl/6 Mice, Anapaula Themann

Open Access Theses & Dissertations

Mood-related disorders, including depression and anxiety, are prevalent among children and adolescents. This poses a public health challenge, given their adverse impact on these young populations. Treatment with the selective serotonin reuptake inhibitor fluoxetine (FLX) is the first line of pharmacological intervention in pediatric patients suffering from affect-related illnesses. Although the use of this antidepressant has been deemed efficacious in the juvenile population, the enduring neurobiological consequences of adolescent FLX exposure are not well understood. For this reason, we explored for persistent molecular adaptations, in the adult hippocampus, as a function of adolescent FLX pretreatment. To do this, we administered …

Identification Of Prostate Cancer-Associated Genomic Alterations By Analyzing Variant Frequencies, Functional Effects, And Protein Interactions, Bofei Wang

Open Access Theses & Dissertations

With the ever-increasing varieties of sequencing techniques, the volume and scope of genomic data are explosively expanded, offering unparalleled opportunities for researchers to study gene-disease associations, identify biomarkers, and thus develop more effective diagnostic and therapeutic strategies. In this project, I have developed a computational workflow and a new scoring scheme, which combine statistical frequency-based analyses with two well-established functional effect prediction tools FATHMM and PROVEAN, to evaluate nonsynonymous GSVs and identify potential cancer-related protein-coding genes for downstream enrichment and protein-protein interaction (PPI) studies.

This method has been applied to process a collection of 503 whole exome sequencing datasets for …

Utilizing Computational Approaches To Study Tubulin- Tubulin Electrostatic Interactions, Tolulope Ayodeji Ale

Open Access Theses & Dissertations

Microtubules play significant roles in transporting cargos within the cell, as well as the cell cycle. They are essentially the highway for the transportation of cell organelles. Understanding the interactions among microtubule components is crucial for the treatment of neurodegenerative diseases and cancer. In this study, we utilize a series of computational approaches to study the electrostatic interactions at the binding interfaces of interacting tubulin monomers. Our study revealed that the electrostatic attractive interactions in the αβ tubulin dimer is the strongest while the interaction between two αβ tubulin dimers in the longitude direction is the weakest. The result identified …

Computational Study Of Grain Structure Evolution In Cdte/Cds Via Molecular Dynamics, Sharmin Abdullah

Open Access Theses & Dissertations

Grain structure analysis plays an important role in the identification of grain boundary characteristics, which can affect the efficiency of Cadmium Telluride/Cadmium Sulfide (CdTe/CdS) solar cells since they can act as recombination centers for carriers. Computer simulations such as molecular dynamics (MD) can be a very convenient and cost- effective method of investigating the growth evolution and grain structure of materials. The recently reported and experimentally validated MD simulated growth of polycrystalline CdTe/CdS films shows that these materials mostly consist of zinc blende (ZB) and wurtzite (WZ) structures, along with highly disordered atoms. However, little information about the semiconductor compound …

The Physiological Factors Of Diabetes And Their Effect On The Cognitive And Emotional Functioning In Older Populations: A Secondary Data Analysis, Celeste Anahi Alvidrez

Open Access Theses & Dissertations

Background: The rates of Type 2 Diabetes (T2D) have increased over the past 20 years in all age groups. The physiological factors that underlie T2D could have impact on specific brain pathways that support cognitive and emotional functioning. Aims and Objective: The goal of this study was to examine whether older Mexican American individuals with a history of T2D were more likely to develop later cognitive impairment and/or depression. Hypotheses: It was predicted that elderly participants (mean age at time of interview = 87.87 years) with a history of T2D onset prior to age 65, are more likely to have …

Examination Of The Association Between C - Reactive Protein(Crp) And Covid-19 Infection Severity And Length Of Hospitalization, Abdulahi Aremu Ayanwale

Open Access Theses & Dissertations

Chronic stress can lead to many systemic complications and low-grade systemic inflammation including increased levels of inflammatory cytokines, such as C-reactive protein (CRP). CRP is a marker of systemic inflammation and is associated with depression and perceived stress. Elevations can result in ineffective immune responses, thereby increasing the risk of complications and mortality from infections. Recent evidence suggests that uncontrolled inflammatory responses associated with COVID 19 are a major determinant of disease severity.  The COVID 19 is transmitted from one person to another through droplets from coughing, sneezing, talking, touching droplets on surfaces and contamination by hand-to-mouth routes. The mechanism …

An Investigation Of Upper Extremity Motor Impairments In Children Diagnosed With Autism Spectrum Disorder: Motor Planning Vs Motor Execution, Patrick Anthony Cereceres

Open Access Theses & Dissertations

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder typically diagnosedwhen a child displays social and communication impairments, repetitive behaviors, and rhythmic movements like hand flapping. This disorder is unique because of the high variability of symptoms displayed between each individual who is diagnosed. Because of this, no neurological or physiological test exists to diagnose a child with ASD. Current diagnostic tests are various forms of interviews or observations which an experienced clinician must administer. While these tests have been instrumental in diagnosing children with ASD, many go undiagnosed, which can be detrimental as they transition into adulthood. Current literature indicates …

Fuel Load, Stand Structure, And Understory Species Composition Following Prescribed Fire In An Old-Growth Coast Redwood (Sequoia Sempervirens) Forest, David Cowman, Will Russell

Faculty Research, Scholarly, and Creative Activity

Background: With the prevalence of catastrophic wildfire increasing in response to widespread fire suppression and climate change, land managers have sought methods to increase the resiliency of landscapes to fire. The application of prescribed burning in ecosystems adapted to fire can reduce fuel load and fire potential while minimizing impacts to the ecosystem as a whole. Coast redwood forests have historically experienced fire from both natural and anthropogenic sources, and are likely to respond favorably to its reintroduction. Results: Random sampling was conducted in three burned sites and in three unburned sites, in an old-growth coast redwood (Sequoia sempervirens [D. …