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Mathematical Modelling Of Gene Regulatory Networks, Ruaa Rifaat Al-Shykhly, Lamyaa Mohammed Hameed

Journal of Economics and Administrative Sciences

This research includes the use of an artificial intelligence algorithm, which is one of the algorithms of biological systems which is the algorithm of genetic regulatory networks (GRNs), which is a dynamic system for a group of variables representing space within time. To construct this biological system, we use (ODEs) and to analyze the stationarity of the model we use Euler's method. And through the factors that affect the process of gene expression in terms of inhibition and activation of the transcription process on DNA, we will use TF transcription factors. The current research aims to use the latest methods …

An Assessment Of The Neurovascular Structures Of The Trigeminal Nerve And Their Relationship To Diet In Primates, Caitlin Yoakum

Graduate Theses and Dissertations

The inferior alveolar nerve (IAN) enters the mandible via the mental foramen, supplies nervous sensation to the mandibular teeth as it travels through the mandibular canal, and exits the mandibular foramen to send information to the brain to maintain chewing cycles and protect the teeth from damage. Although bony canals and foramina have been shown to form around soft-tissue structures, there are some examples (e.g., the hypoglossal nerve/canal) where the nervous structures do not comprise most of the canal/foramina space. It is important to know the size of nerves because it has been established that larger nerves convey more information …

Canine Microwear In Relation To Diet In Sumatran Primates And African Great Apes, Putu Pujiantari

Graduate Theses and Dissertations

This thesis considers canine microwear in relation to diet in five Sumatran primates (Pongo abelii, Hylobates lar, Hylobates agilis, Presbytis thomasi, and Macaca fascicularis) and two African great apes (Pan paniscus and Pan troglodytes schweinfurthii) using both microwear texture analysis and microwear feature analysis techniques. Statistical results for texture analysis show that there are significant differences in scale of maximum and heterogeneity. This indicates that some species have large pits on their canine surfaces, having these dominated by deep features at coarse scale yet have a slight microwear heterogeneity. For feature analysis, all variables show statistically significant variation. Variance in …

The Relationship Of Hospital Ceo Gender And The Patient Experience: The Role Of The Mediating Effects Of Hospital Characteristics, Lanean M. Lang

Electronic Theses and Dissertations

In this quantitative study, I investigated CEO gender and the patient experience in acute care hospitals in Texas for 2019. As the patient-experience has been the metric for quality patient care and hospital reimbursements, hospital CEOs play an important role in promoting positive patient experience as they lead the organization in strategic goals. The study is relevant as a shortage of experienced and qualified healthcare leaders is expected as baby-boomers retire. The lack of women leaders remains a challenging issue. The purpose of the study was to assess the gender differences of the CEO on the impact of patient experience …

Agents Of Bioshield: The Fda, Emergency Use Authorizations, And Public Trust, Kirstiana Perryman

Georgia Law Review

The SARS-CoV-2 pandemic spurred the U.S. Food & Drug Administration (FDA) to utilize the Emergency Use Authorization (EUA) procedure more than ever before. The pandemic pushed the relatively obscure procedure into public consciousness, making it a frequent topic of discussion and debate. The EUA procedure permits the FDA Commissioner to authorize the introduction of drugs, devices, or biological products into interstate commerce for use in an actual or potential emergency. To issue an authorization, the FDA Commissioner must determine that it is “reasonable to believe,” based on the “totality of the evidence,” that the product “may be effective.” This standard …

Mechanisms And Applications Of Improved Protein Analysis By Desorption Electrospray Ionization Mass Spectrometry (Desi-Ms), Roshan Javanshad

Dissertations

Electrospray ionization mass spectrometry (ESI-MS) is a soft ionization technique that allows detection of macromolecules, such as intact proteins, by the formation of multiply charged ions from solutions. Desorption electrospray ionization mass spectrometry (DESI-MS) is an ambient ionization technique that directly samples analyte from a surface during ESI-MS analysis. Although DESI-MS is highly accomplished at the analyses of metabolites, lipids, and other small molecules, it is far more limited when it comes to protein analysis. While most of the field in ambient ionization MS has moved towards primarily applications, our approach has been to explore the use of DESI-MS and …

Advanced Risk Models To Predict Surgical Site Infections Using Machine Learning Approaches And Risk-Adjusted Control Charts, Rabia Emhamed Al Mamlook

Dissertations

Even though most infections are treatable with antibiotics, Surgical Site Infections (SSIs) remain a significant healthcare problem as they increase hospital stays, require additional treatments, reduce a patient’s quality of life, and increase morbidity and mortality. To reduce the risks and to encourage the highest quality healthcare, it is important to measure, predict, and monitor the risk of SSIs. Preoperative prediction of SSIs is essential to facilitate the implementation of preventative strategies for high-risk patients. The overarching goal of this dissertation is to investigate new opportunities of using machine-learning (ML) to improve the accuracy and use of pre-operative prediction models …

Relation Between Epithelial-Mesenchymal Transition And Colorectal Cancer Prognosis: Impact Of Smad4 And Β-Catenin Markers, Mona Emile, Dina Ibrahim, Amr El-Karef, Ibrahim Eldosoky, Mohammed Awad

Mansoura Medical Journal

Colorectal cancer (CRC) is one of the most prevalent and deadly neoplasms. It develops through several molecular pathways and varies in clinical presentation and patient prognosis. The prognosis of CRC is influenced by variable pathologic and molecular variables. Understanding the molecular basis that promote CRC progression, invasive and metastatic features, is important for establishing effective CRC therapeutic strategies. Epithelial mesenchymal transition (EMT) is regarded to be key hallmark of CRC carcinogenesis, providing metastatic capacities to cancer cells by promoting motility and invasion. During this process, epithelial markers such as E-cadherin are down-regulated, whereas mesenchymal markers such as Vimentin are up-regulated. …

Clinical Scoring For Early Detection Of Prediabetes In Egyptian Population, Ahmed Abdel-Hamid, Enas Elkhamisy, Megahed Abo Elmagd

Mansoura Medical Journal

Background: Prediabetes is a wide spread condition where blood glucose is above normal, but it does not measure up to the criteria of diabetes mellitus. Yet there is no national scoring system for prediabetes according to the potential risk factors. Methods: A case-control study has been carried out in Mansoura Specialized Hospital. Subjects have been recruited from out-patients clinic in the period from October 2018 to August 2019. Those with prediabetes had been assigned to be the case group whereas control subjects were those who had a normal HbA1C. A scoring system was based on risk factors of prediabetes by …

Non-Resectional Procedures As Treatment Options For Hemorrhoidal Disease., Esraa Daif, Hossam Elfeki, Ashraf Shoma

Mansoura Medical Journal

Hemorrhoids have been recorded through hundreds of years of history. It is a very common condition affecting millions of people around the world every year with an estimated prevalence of 4.4% of the population in the United States. Hemorrhoids are defined as the pathological enlargement and downward displacement of the anal cushions. The risk factors of this condition include a low-fiber diet, constipation, and prolonged straining. It is clinically manifested by painless bleeding with the bowel movement with or without prolapse. Other symptoms like pain or pruritus that affect the patients’ quality of life. Hemorrhoids can be managed by multiple …

Reconstruction Of Glossectomy Defects Post Oncologic Resection, Sara Elbaz, Shadi Awny, Ashraf Shoma

Mansoura Medical Journal

The tongue is a muscular organ completely covered by mucous membrane and made up of two portions divided by the V-shaped sulcus terminalis: an anterior 2/3 (oral tongue) and a posterior 1/3 (tongue base). The tongue is essential to normal speech as well as swallowing process, and healthy tongue function is vital within the general quality of life. Tongue cancers are aggressive tumors with poor prognosis, so the early detection markedly raises the possibility of cure with minimal impairment and deformity. Management needs a surgical, medical and radiation oncologist in association with speech therapist, physical rehabilitation, and psychologists. In addition …

2021 December, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for December of 2021.

Youth Mental Health Service Preferences And Utilization Patterns Among Latinx Caregivers, Alejandro L. Vázquez, María De La Caridad Alvarez, Cynthia M. Navarro Flores, José Manuel González Vera, Tyson S. Barrett, Melanie M. Domenech Rodríguez

Psychology Faculty Publications

Latinx caregivers underutilize traditional youth mental health services (MHS) relative to their White counterparts. Disparities may be explained by barriers preventing engagement in traditional MHS. A potential mismatch between available services and preferred culturally appropriate healing practices may also contribute to treatment disparities. The current study examined Latinx caregivers’ perceived need for and utilization of support services in relation to family characteristics, youth problem-type, and barriers to care. Findings were contextualized by assessing caregiver preferences for addressing youth psychopathology. The study consisted of 598 Latinx caregivers from across the United States. Descriptive statistics and binary logistic regression models were used …

Identification And Characterization Of Bisbenzimide Compounds That Inhibit Human Cytomegalovirus Replication, Nicole Falci Finardi, Hyeongjun Kim, Lee Z. Hernandez, Matthew R. G. Russell, Catherine M-K Ho, Vattipally B. Sreenu, Hannah A. Wenham, Andy Merritt, Blair L. Strang

Physics & Astronomy Faculty Publications

The shortcomings of current anti-human cytomegalovirus (HCMV) drugs has stimulated a search for anti-HCMV compounds with novel targets. We screened collections of bioactive compounds and identified a range of compounds with the potential to inhibit HCMV replication. Of these compounds, we selected bisbenzimide compound RO-90-7501 for further study. We generated analogues of RO-90-7501 and found that one compound, MRT00210423, had increased anti-HCMV activity compared to RO-90-7501. Using a combination of compound analogues, microscopy and biochemical assays we found RO-90-7501 and MRT00210423 interacted with DNA. In single molecule microscopy experiments we found RO-90-7501, but not MRT00210423, was able to compact DNA, …

Open Education Resources And The Academic Library, Jeanette A. Parker

The Christian Librarian

Librarians have an opportunity to assist faculty and students in adoption and use of OER, or Open Educational Resources. Faculty and students present differing perspectives and responses to OER that may inhibit their use. Libraries are known for providing access to resources and educational training or workshops on the use of new technologies and existing or new resources. Libraries are also accustomed to providing proxied access to online resources, hosting repositories and developing policies for management, curation and collection of a wide array of materials and resources. By helping to develop and organize an OER initiative of any kind at …

Effects Of Localized Oxygen Production By Electrolysis On The First-Generation Glucose Sensor Response, Nandita Halder

Graduate Theses and Dissertations

Glucose sensors are very important for detecting blood glucose both in vitro and in vivo. First-generation glucose biosensors were based on the glucose oxidase (GOx) enzyme using molecular oxygen as the electron acceptor and therefore oxygen dependent. Unfortunately for in-vivo work, oxygen in the body is variable and limited. Alternative approaches to overcome the oxygen dependency came with their own limitations. The widely used and commercially available ex-vivo glucose test strip uses a mediator in place of oxygen to free it from oxygen dependency. The mediator-based technology, in most cases cannot be transferred to in vivo applications due to the …

Substance Use And Psychological Distress Correlates Of Sleep Quality Among College Students, Juanybeth Morales Ortega

Graduate Theses and Dissertations

Poor sleep quality in college students is a major problem associated with adverse health outcomes, cognitive performance, substance use, and psychological distress. Our study explored how substance use and psychological distress are associated with the sleep quality of college students. We analyzed secondary data collected in 2019 using a cross-sectional survey design. Measures included participants’ demographic characteristics, sleep quality using the Pittsburg Sleep Quality Index (PSQI), drug use, depression using the Patient Health Questionnaire-9 (PHQ-9), and suicidality. After excluding participants with missing information for sleep quality, a total of 555 students remained for the analysis. Our bivariate analysis found that …

Assessing The Use Of Smartphones In Agriculture, Katherine Mary Carpenter

Theses

Smartphones are an as yet untapped resource available to agriculture. They are ubiquitous across the globe yet have not previously been tested as a resource available to farmers. Imaging methods such as unmanned aerial vehicles (UAV) and satellite imaging have been well-explored and employed in various aspects of agriculture; however, such methods can be cost-prohibitive and at the mercy of another company or agency. If smartphones could be shown to capture color in such a way that relates in a quantifiable way to data measured by laboratory-grade equipment they could prove to be extremely valuable to farmers. Cutting out expensive …

Does Bedtime Music Listening Improve Subjective Sleep Quality And Next-Morning Well-Being In Young Adults? A Randomized Cross-Over Trial, Nadyana M. Majeed, Verity Y. Q. Lua, Jun Sen Chong, Zoey Lew, Andree Hartanto

Research Collection School of Social Sciences

Previous research has found that young adults exhibit patterns of poor sleep and that poor sleep is associated with a host of negative psychological consequences. One potential intervention to improve sleep quality is listening to music at bedtime. Although there exist previous works investigating the efficacy of listening to music as a form of sleep aid, these works have been hindered by statistically weak designs, a lack of systematic investigation of critical characteristics of music that may affect its efficacy, and limited generalizability. In light of the limitations in the existing literature, a 15-day randomized cross-over trial was carried out …

Effect Of 3 Days Of Oral Azithromycin On Young Children With Acute Diarrhea In Low-Resource Settings: A Randomized Clinical Trial, Antibiotics For Children With Diarrhea (Abcd) Study Group, Tahmeed Ahmed, Farah Naz Qamar, Mohammad Tahir Yousafzai, Shahida Qureshi, Sadia Shakoor, Rozina Thobani, Aneeta Hotwani, Furqan Kabir, Jan Mohammed

Department of Paediatrics and Child Health

Importance: World Health Organization (WHO) guidelines do not recommend routine antibiotic use for children with acute watery diarrhea. However, recent studies suggest that a significant proportion of such episodes have a bacterial cause and are associated with mortality and growth impairment, especially among children at high risk of diarrhea-associated mortality. Expanding antibiotic use among dehydrated or undernourished children may reduce diarrhea-associated mortality and improve growth.
Objective: To determine whether the addition of azithromycin to standard case management of acute nonbloody watery diarrhea for children aged 2 to 23 months who are dehydrated or undernourished could reduce mortality and improve linear …

Mitochondrial Aberrations During The Progression Of Disuse Atrophy Differentially Affect Male And Female Mice, Megan E. Rosa-Caldwell, Seongkyun Lim, Wesley S. Haynie, Jacob L. Brown, David E. Lee, Kirsten R. Dunlap, Lisa T. Jansen, Tyrone A. Washington, Michael P. Wiggs, Nicholas P. Greene

Health, Human Performance and Recreation Faculty Publications and Presentations

Background

Disuse decreases muscle size and is predictive of mortality across multiple pathologies. Detriments to mitochondrial function are hypothesized to underlie disuse-induced muscle atrophy. Little data exist on early mechanisms contributing to onset of these pathologies, nor is it known how they differ between sexes. The purpose of this study was to examine differential and conserved responses to mitochondrial quality control in male and female mice during the development and progression of disuse-induced atrophy.

Methods

One hundred C57BL/6J mice (50 male and 50 female) were hindlimb unloaded to induce disuse atrophy for 0 (con), 24, 48, 72, or 168 h. …

Applying Behavioral And Physiological Measures To Assess The Relative Impact Of The Prolonged Covid-19 Pandemic Closure On Two Mammal Species At The Oregon Zoo: Cheetah (A. Jubatus) And Giraffe (G. C. Reticulata And G. C. Tippelskirchii), Laurel Fink, Candace D. Scarlata, Becca Vanbeek, Todd Bodner, Nadja C. Wielebnowski

Biology Faculty Publications and Presentations

The effect of visitor presence on zoo animals has been explored in numerous studies over the past two decades. However, the opportunities for observations without visitors have been very limited at most institutions. In 2020, the Oregon Zoo was closed, in response to the global SARSCoV-2 (COVID-19) pandemic, from 15 March 2020 to 12 July 2020, resulting in approximately four consecutive months without visitor presence. This study aimed to quantify potential behavioral and hormonal changes expressed during two transition periods in zoo visitor attendance: the initial time period before and after closure in March 2020 and time before and after …

A Proposed Mechanism For Financial Reporting On Sustainable Investment And Its Role In Achieving Value Added - Applied In The Iraqi Midland Refineries Company-, Mohammed Ataallah Ali, Salman Hussin Abdullah

Journal of Economics and Administrative Sciences

The research aims to develop a proposed mechanism for financial reporting on sustainable investment that takes the specificity of these investments. To achieve this goal, the researcher used (what if scenario) where the future financial statements were prepared for the year 2026, after completion of the sustainable project and operation, as the project requires four years to be completed. The researcher relied on the results of the researchers collected from various modern sources relevant to the research topic and published on the internet, and the financial data and information obtained to assess the reality of the company's activity and its …

Sigesn Light-Emitting Devices: From Optical To Electrical Injection, Yiyin Zhou

Graduate Theses and Dissertations

Si photonics is a fast-developing technology that impacts many applications such as data centers, 5G, Lidar, and biological/chemical sensing. One of the merits of Si photonics is to integrate electronic and photonic components on a single chip to form a complex functional system that features compact, low-cost, high-performance, and reliability. Among all building blocks, the monolithic integration of lasers on Si encountered substantial challenges. Si and Ge, conventional epitaxial material on Si, are incompetent for light emission due to the indirect bandgap. The current solution compromises the hybrid integration of III-V lasers, which requires growing on separate smaller size substrates …

Latent Tuberculosis Infection In A Patient With A Negative Interferon Gamma Release Assay Prior To Biologic Initiation For Crohn's Disease, Muaaz Masood, Reid Wasserman, Vignesh Nagesh, Humberto Sifuentes

Student Publications

CASE: Biologic therapy has revolutionized the treatment of inflammatory bowel disease (IBD). Nevertheless, it is well known that biologics are associated with an increased risk of opportunistic infections such as tuberculosis (TB). Screening tests indicated before biologic initiation, namely interferon gamma release assay (IGRA) or tuberculin skin tests (TST), may be falsely negative. We present the case of a male with uncontrolled Crohn’s disease (CD) with a negative screen for TB and how a high index of suspicion led to the discovery of latent tuberculosis infection (LTBI) and the appropriate deferment of biologic therapy. A 63-year-old South Asian male with …

English-To-Ipa Transcription, Riley Roberts

Undergraduate Honors Capstone Projects

The purpose of this project was to create a tool that could automate English-to-IPA (International Phonetic Alphabet) transcription. Research was done to determine what would be required to perform such a transcription. After researching and experimenting with existing tools, it was determined that developing the signal processing and Artificial Intelligence model portion of the application would be too intensive to successfully complete within the timeframe of this project.

The choice was made to develop an iOS application, with the Python library Allosaurus used to do the speech processing and as the Artificial Intelligence model. This model was then deployed in …

Exploring The Relationship Between Trauma, Motivation, Current Stress, And Immigrant Elementary Students, Jayme Branagh Landon

Doctoral Dissertations and Projects

The current study explored the relationship between past trauma of immigrant students and motivation in a group of public-school elementary students in Washington state. Additionally, this study explored how stress affects academic motivation. It was hypothesized that past trauma would significantly affect immigrant student motivation and that current stress would moderate motivation in school. Only students with past trauma experience and who qualify as an immigrant, were included in this study. Participants completed The Cameron Complex Trauma Interview (CCTI), Motivated Strategies for Learning Questionnaire (MSLQ), and The Perceived Stress Scale for Children (PSS-C). While motivation has been studied, the factors …

Implementing Christlike Love In The Johnson Grove Baptist Church, Robert Lee Sullivan Jr.

Doctoral Dissertations and Projects

This research project was paramount, the title expressed the vision and purpose of the researcher as an under-shepherd of Christ. Implementing Christlike Love was not just designed for this church, but the key principle that was used in this project can inspire others. The problem addressed was a lack of true Christlike love in this church. Believers assumed that loving others would be automatic but loving like Christ requires God’s help. The purpose of this project was to appraise and resolve the perceived lack of Christlike love within the Johnson Grove Baptist Church. This researcher sought to provide a remedy …

Improving Students' Scores On The Georgia End Of Course Assessment For Biology, Natasha Takia Simpson

Doctoral Dissertations and Projects

The purpose of this applied study is to solve the problem of underperforming student test scores on the End of Course Biology assessment for high school students at an alternative school in Georgia, and to formulate a solution to address the problem. A multi-method design will be used consisting of both qualitative and quantitative approaches. The first approach will be structured interviews with the administration. The second approach will be focus groups with teachers. The third approach will analyze quantitative data from student surveys. The results may provide insight into an underlying problem in underperforming scores on the End of …

The Effectiveness Of Faith-Based Group Life Coaching On Stress And Anxiety Levels In Spouses Of Veterans With Post-Traumatic Stress Disorder, Esperanza Pilar Guerra Lugo

Doctoral Dissertations and Projects

Veterans who courageously served in the military are often diagnosed with post-traumatic stress disorder and their spouses are at high risk of suffering in silence from stress and anxiety. Many spouses are also their Veteran’s caregiver which leaves little time for their own self-care needs. Being a Veteran’s 24-hour caregiver can lead to poor physical and mental health, aggravating spouses stress and anxiety levels which is often only treated with medication or goes untreated due to lack of mental health care access and the stigma that comes with it. The literature review explores the research gap of how online faith-based …