Digital Commons Network^™

Addressing The Mental Health Needs Of Children Affected By Hiv In Rwanda: Validation Of A Rapid Depression Screening Tool For Children 7–14 Years Old, Agnes Binagwaho, Eric Remera, Alice Uwase Bayingana, Darius Gishoma, Kirstin Woody Scott, Madeline Goosman, Eliza Campbell, Mawuena Agbonyitor, Yvonne Kayiteshonga, Sabin Nsanzimana

Dartmouth Scholarship

Background: Depression in children presents a significant health burden to society and often co-exists with chronic illnesses, such as human immunodeficiency virus (HIV). Research has demonstrated that 10–37% of children and adolescents living with HIV also suffer from depression. Low-and-middle income countries (LMICs) shoulder a disproportionate burden of HIV among other health challenges, but reliable estimates of co-morbid depression are lacking in these settings. Prior studies in Rwanda, a LMIC of 12 million people in East Africa, found that 25% of children living with HIV met criteria for depression. Though depression may negatively affect adherence to HIV treatment among children …

Sprd: A Surface Plasmon Resonance Database Of Common Factors For Better Experimental Planning, Purushottam B. Tiwari, Camelia Bencheqroun, Mario Lemus, Taryn Shaw, Marilyn Kouassi-Brou, Adil Alaoui, Aykut Üren

Dartmouth Scholarship

Background: Surface plasmon resonance is a label-free biophysical technique that is widely used in investigating biomolecular interactions, including protein-protein, protein-DNA, and protein-small molecule binding. Surface plasmon resonance is a very powerful tool in different stages of small molecule drug development and antibody characterization. Both academic institutions and pharmaceutical industry extensively utilize this method for screening and validation studies involving direct molecular interactions. In most applications of the surface plasmon resonance technology, one of the studied molecules is immobilized on a microchip, while the second molecule is delivered through a microfluidic system over the immobilized molecules. Changes in total mass on …

Genome-Resolved Metagenomics Reveals Role Of Iron Metabolism In Drought-Induced Rhizosphere Microbiome Dynamics, Ling Xu, Zhaobin Dong, Dawn Chiniquy, Grady Pierroz, Siwen Deng, Cheng Gao, Spencer Diamond, Tuesday Simmons, Heidi M.L. Wipf, Daniel Caddell, Nelle Varoquaux, Mary A. Madera, Robert Hutmacher, Adam Deutschbauer, Jeffery A. Dahlberg, Mary Lou Guerinot, Elizabeth Purdom, Jillian F. Banfield, John W. Taylor, Peggy G. Lemaux

Dartmouth Scholarship

Recent studies have demonstrated that drought leads to dramatic, highly conserved shifts in the root microbiome. At present, the molecular mechanisms underlying these responses remain largely uncharacterized. Here we employ genome-resolved metagenomics and comparative genomics to demonstrate that carbohydrate and secondary metabolite transport functionalities are overrepresented within drought-enriched taxa. These data also reveal that bacterial iron transport and metabolism functionality is highly correlated with drought enrichment. Using time-series root RNA-Seq data, we demonstrate that iron homeostasis within the root is impacted by drought stress, and that loss of a plant phytosiderophore iron transporter impacts microbial community composition, leading to significant …

Turning Orphans For A Profit: The Orphan Drug Act Is Due For An Overhaul, Kelly L. Mckinney

Hofstra Law Review

No abstract provided.

Prenatal Exposure To Per- And Polyfluoroalkyl Substances And Child Neurodevelopment, Jiwon Oh

Earth & Environmental Sciences Dissertations - Archive

Pregnant women are exposed to per- and polyfluoroalkyl substances (PFAS) primarily via ingestion of contaminated food, water, and house dust. PFAS in pregnant women can be transferred to their child through the placenta during pregnancy. Many long-chain PFAS have been frequently detected in blood of pregnant women, amniotic fluid, and umbilical cord blood for the last few decades. Prenatal exposure to PFAS has shown potential to adversely affect offspring’s neurodevelopment in laboratory animals. However, epidemiological evidence on associations between prenatal PFAS exposure and child neurodevelopment remains inconsistent. My dissertation research consists of four sub-studies whose objectives are (1) to examine …

Hplc Analysis Of Potentially Counterfeit Samples Of Amoxicillin, Hunter Noel

Undergraduate Honors Theses

The global phenomenon of drug counterfeiting is a threat to both patients and healthcare systems alike. Counterfeit drugs can build bacterial resistance to antibiotics, undermine public trust in prescribed medications, fail to alleviate sickness, or even hurt the patient. Annually, thousands of people die from ingesting fake drugs (Blackstone et al., 2014). In order to combat the global prevalence of drug counterfeiting, it is important to test suspect drugs for legitimacy and then report findings back to relevant authorities that can enforce drug quality standards (Lieberman, 2018). High performance liquid chromatography (HPLC) is an analytical method that can determine the …

Can A Large-Landscape Conservation Vision Contribute To Achieving Biodiversity Targets?, Mark Hebblewhite, Jodi A. Hilty, Sara Williams, Harvey Locke, Charles Chester, David Johns, Gregory Kehm, Wendy L. Francis

Political Science Faculty Publications and Presentations

Founded in 1993, the Yellowstone to Yukon (Y2Y) vision was one of the earliest large-landscape conservation visions. Despite growing recognition of large-landscape conservation strategies, there have been few tests to date of conservation gains achieved through such approaches. We tested for conservation gains in the Y2Y region of North America following initiation of the Y2Y conservation vision in 1993 using a counterfactual spatiotemporal comparison and tracking change in five different conservation metrics. First, we enumerated the area of land within Y2Y in designated protected areas. We then compared the rate of change of protected area growth before- and after-initiation of …

Raps Sheet, December 2021, Retirement Association Of Portland State

RAPS Sheet: Monthly Newsletter

No abstract provided.

Development Of Bioaffinity Based Assays For Forensic Applications, Juliana Maria Agudelo Cano

Legacy Theses & Dissertations (2009 - 2024)

In the field of forensic science, body fluids are a major contributor of evidence in investigations. However, body fluids are usually used only for their genetic content, overlooking its unique composition of proteins and low-molecular-weight compounds that often serve as biomarkers in clinical diagnostics. This investigation aimed to develop simple, effective, and economical models that can be used to identify different attributes of the originator. The focus of this research was to develop biocatalytic cascades that could analyze body fluids by using UV-Vis spectroscopy. These models could be implemented in forensic settings, as well as in biometric authentications. The central …

The Assemblage Of The Dead : Speech, Subjectivity, And Being Human, Nazia Manzoor

Legacy Theses & Dissertations (2009 - 2024)

ABSTRACT“The Assemblage of the Dead: Speech, Subjectivity, and Being Human” reimagines the construct of the human as a political subject of the state through a bio(necro)political lens. The project re-envisions the conceptual framework of biopolitics through an engagement with the figure of the living dead, centralized in Giorgio Agamben’s work through his casting of the figure of the Muselmann as the cipher that reveals the limits of humanity and being human. With a bid to counter-narrate the twinning of death and resistance and death and subjectivity as foundational markers of humanity in current critical scholarship of the field, this project …

Modulation Of Rho Termination : Expectation Vs Reality, Kavya Sri Sai Chegireddy

Legacy Theses & Dissertations (2009 - 2024)

Transcription termination factor Rho is an essential protein in many bacteria. Rho is an ATP-dependent RNA helicase that accounts for 20-50% of termination events in Escherichia coli and plays an important role in preventing pervasive transcription that otherwise might be lethal to bacteria. Rho termination usually occurs in the 3’ UTRs and non-coding regions of the DNA, and the actively transcribing RNA is believed to be protected by translating ribosomes from Rho termination since both transcription and translation are a simultaneous process in prokaryotes. However, in reality, Rho terminates transcription of some protein-coding genes, and fails to terminate transcription of …

Sex Differences In Context Fear Neural Circuitry And Behavior Across Development, Lorianna Marie Colon

Legacy Theses & Dissertations (2009 - 2024)

Over the span of five decades, staggering progress has been made in elucidating the neural circuits involved in fear learning. Research focused on rodents and healthy individuals has been instrumental in elucidating how abnormalities in this circuitry may lend to increased prevalence of various fear and anxiety disorders. However, many of the key findings concerning the acquisition, storage, and retrieval of fear memories have been established in the adult male rodent, leaving a gap in knowledge as to whether females and developing animals process fear and stress inducing information in a similar fashion. Compared to men, women are twice as …

Development Of Visible-Light-Mediated Photoredox Catalysis, Sarbjeet Kaur

Legacy Theses & Dissertations (2009 - 2024)

ABSTRACT

Empowering Melatonin Therapeutics With Drosophila Models, Cassandra Millet-Boureima, Caroline C. Ennis, Jurnee Jamison, Shana Mcsweeney, Anna Park, Chiara Gamberi

Biology

Melatonin functions as a central regulator of cell and organismal function as well as a neurohormone involved in several processes, e.g., the regulation of the circadian rhythm, sleep, aging, oxidative response, and more. As such, it holds immense pharmacological potential. Receptor-mediated melatonin function mainly occurs through MT1 and MT2, conserved amongst mammals. Other melatonin-binding proteins exist. Non-receptor-mediated activities involve regulating the mitochondrial function and antioxidant cascade, which are frequently affected by normal aging as well as disease. Several pathologies display diseased or dysfunctional mitochondria, suggesting melatonin may be used therapeutically. Drosophila models have extensively been employed to study disease pathogenesis …

Adverse Childhood Experiences And Social Determinants Of Health In Relation To Pediatric Intensive Care Unit Admissions, Kasey Davis

The Eleanor Mann School of Nursing Undergraduate Honors Theses

This literature review was conducted in order to examine the correlation between adverse childhood experiences (ACEs), social determinants of health and pediatric intensive care unit (PICU) admissions. Oftentimes, those admitted as patients in the PICU come from homes in which social determinants of health, such as poverty and lack of access to healthcare, and ACEs, such as abuse and neglect, are prevalent. Systematic studies of existing literature and experience in the hospital setting revealed the ways in which these conditions often cause children to reach such poor health conditions that they must be admitted to the PICU. In order to …

Implementing 2nd Milk’S Use Of The World Health Organization Standardized Growth Charts To Better Track The Growth And Development Of The Malnourished And Orphaned Infants In Their Supplemental Nutrition Program In Malawi, Allie Wycoff

The Eleanor Mann School of Nursing Undergraduate Honors Theses

This article considers the history and implications of the World Health Organization (WHO) standardized growth charts as well as the significant impact that growth chart utilization may have on 2^ndMilk’s ability to understand and track the nutritional status of the malnourished orphaned infants in their formula program. Specifically, this literature review examines whether or not the WHO growth charts are a meaningful tool for 2^ndMilk to adopt into their monthly baby assessments. The WHO growth charts are calibrated to express an accepted international “norm” for what an adequately nourished child looks like. In a recent service-learning …

Increased Use Of Opioids Perioperatively Leads To Unmanaged Postoperative Pain, Halida Sehic

Nursing | Senior Theses

Background: Total knee and total hip joint arthroplasty are two frequently preformed surgeries, with 5.2 million total knee arthroplasties performed the United States between the year 2000 and 2010 (Williams et al., 2015). Opioids are widely used to manage pain for patients undergoing total joint arthroplasty. However, use of opioids is associated with undesirable adverse effects, such as nausea and respiratory depression, (Johnson et al., 2011). In postoperative patients following total joint replacement, 75 % of the patients complain of inadequately controlled moderate to severe pain (De Luca et al., 2018). Increased use and overprescribing increase tolerance to opioids …

Tdec 2021 Annual Report, Tennessee. Department Of Environment & Conservation.

Annual Report

No abstract provided.

Second Look Commission 2021 Annual Report, Tennessee. Commission On Children And Youth.

Second Look Commission Annual Report

No abstract provided.

Kaleidoscopic Katas: An Intercultural Somatic Curriculum For Holistic Health, Emily Seymour

Master's Theses

The intent of this research study was to combine three African and Eastern somatic movement practices into a modern dance curriculum. Few studies have investigated the therapeutic value of subtle body awareness in a dance class context. This integrative study combined psychological, physiological, and contemplative pedagogical approaches, which led to the development of a comprehensive five-part workshop with five adult participants. This ten-hour online class series involved learning a traditional Afro-Haitian serpent dance called the Yanvalou, the Tantric practice of Chakra Yoga, and the Five Animals qigong. The original curricular goal was to combine these three modalities into five sequential …

Balancing Increased Physical Demands: An Analysis Of Cross-Training Practices In Young Adult Ballet Dancers, Brooke Yuspeh

Master's Theses

The purpose of this study was to see what young adult ballet dancers knew about cross-training and if they found cross-training methods they practiced effective in supporting their dance technique and helping to prevent injuries. To uncover this information, the researcher used the following essential questions to guide this project: Q1: How do young adult ballet dancers practice cross-training? Q2: Which of these cross-training modalities are considered most effective? The research instruments used in this study included a survey consisting of multiple-choice, multiple-selection, and open-ended questions and an optional journal reflection consisting of open-ended questions. There were a total of …

Knowledge And Practice On Pest Management Of Ethnic Potato Farmers In Southern Shan State, Myanmar, Pyae Pa Pa Aung, Supawan Visetnoi

Jurnal Geografi Lingkungan Tropik (Journal of Geography of Tropical Environments)

Potato is cultivated as the main tuber crop which is essential for ethnic farmers’ household income in Southern Shan State, Myanmar. Most ethnic farmers use chemicals widely to enhance crop yield and reduce pests. Overuse and misuse of pesticides could lead to a series of health impacts and environmental issues. The main aim of the study is to explore farmers’ current practices and knowledge level on pesticides in potato production. The participants of 100 farmers were chosen from each village with a cluster and purposive sampling technique using structured questionnaires to collect the data from a village in Kalaw Township. …

Biodiversity Scale-Dependence And Opposing Multi-Level Correlations Underlie Differences Among Taxonomic, Phylogenetic And Functional Diversity, Nadejda A. Mirochnitchenko, Erica F. Stuber, Joseph J. Fontaine

Nebraska Cooperative Fish and Wildlife Research Unit: Staff Publications

Aim: Biodiversity is a multidimensional property of biological communities that represents different information depending on how it is measured, but how dimensions relate to one another and under what conditions is not well understood. We explore how taxonomic, phylogenetic, and functional diversity can differ in scale-of-effect dependence and habitat-biodiversity relationships, and subsequently how spatial differences among biodiversity dimensions may arise. Location: Nebraska, United States. Taxon: Birds. Methods: Across 2016 and 2017, we conducted 2,641 point counts at 781 sites. We modeled the occupancy of 141 species using Bayesian Bernoulli-Bernoulli hierarchical logistic regressions. We calculated species richness (SR), phylogenetic diversity (PD), …

If You Think Ai Won't Eclipse Humanity, You're Probably Just A Human, Gary D. Brown

William & Mary Bill of Rights Journal

Building machines that can replicate human thinking and behavior has fascinated people for hundreds of years. Stories about robots date from ancient history through da Vinci to the present. Whether designed to save labor or lives, to provide companionship or protection, loyal, capable, productive machines are a dream of humanity.

The modern manifestation of this interest in using human-like technology to advance social interests is artificial intelligence (AI). This is a paper about what that interest in AI means and how it might develop in the world of national security.

This abstract has been adapted from the author's introduction.

Facing Injustice: How Face Recognition Technology May Increase The Incidence Of Misidentifications And Wrongful Convictions, Laura Moy

William & Mary Bill of Rights Journal

Part I of this Article explains how face recognition is used in conjunction with eyewitness identification in the law enforcement context. Part II explores how and why the growing use of face recognition technology may increase, rather than decrease, misidentifications and therefore wrongful convictions. Part III recommends policy changes that should be considered, including some of the reforms to eyewitness identification procedures that have been advanced by others.

This abstract has been adapted from the author's introduction.

Docket Selection And Judicial Responsiveness: The Use Of Ai In The Colombian Constitutional Court, Pablo Rueda Saiz

William & Mary Bill of Rights Journal

This Article addresses some of the limitations of AI as a tool to preselect a long or shortlist of cases for a court at the apex of the judicial system to review. It focuses on the Colombian Constitutional Court, as an example of a court at the apex of the judicial system that has been historically responsive to claims for fundamental rights. Docket selection is an example of a classification problem using supervised learning, in which a machine groups data according to preestablished characteristics.

This Article draws from two different bodies of literature to analyze the consequences of using AI …

Serum Uric Acid And Its Change With The Risk Of Type 2 Diabetes: A Prospective Study In China, Haiyan Su, Tong Liu, Yupeng Li, Yuxin Fan, Baoping Wang, Ming Liu, Gang Hu, Zhaowei Meng, Qing Zhang

Population and Public Health Science Faculty Publications

Objective: To assess the association of baseline uric acid levels and their changes from baseline to Year 1 with the risk of type 2 diabetes. Research design and methods: This study cohort included 9471 subjects without a history of diabetes at baseline. The incident diabetes was diagnosed according to the American Diabetes Association standard. Results: During a mean follow-up of 2.9 years, we identified 762 type 2 diabetes cases. Multivariate-adjusted hazard ratios (HRs) of diabetes across baseline tertiles of serum uric acid were 1.00, 1.15, and 1.32 (P for trend = 0.018), respectively. Participants with hyperuricemia compared with those without …

Physical Activity And Sleep Duration During Pregnancy Have Interactive Effects On Caesarean Delivery: A Population-Based Cohort Study In Tianjin, China, Yingzi Yang, Weiqin Li, Wen Yang, Leishen Wang, Jinnan Liu, Junhong Leng, Wei Li, Shuo Wang, Jing Li, Gang Hu, Zhijie Yu, Xilin Yang

Population and Public Health Science Faculty Publications

Background: There were inconsistent findings in the literature regarding the associations of physical activity and sleep duration during pregnancy with caesarean delivery for different reasons. It was also unknown whether physical activity and sleep duration during pregnancy had interactive effects on the risks of different types of caesarean delivery. The study aimed to investigate the effects of physical activity, sleep duration and their interactions on the risk of caesarean delivery for medical reasons and non-medical reasons. Methods: From October 2010 to August 2012, a prospective population-based cohort of 13,015 pregnant women was established in six central urban districts of Tianjin, …

Examining An Intersection Of Environmental Justice And Covid-19 Risk Assessment: A Review, Ashley Ellis

Honors Theses

This study views the risks associated with the novel coronavirus (COVID-19) as an environmental injustice issue due to the connection between existing environmental disparities and the disproportional negative impacts brought upon by the virus. The social and health determinants attributed to those environmental disparities have traditionally been evaluated as individual risk factors, an approach that fails to gauge the complexity of an environmental injustice issue. This study employs the emerging theory of intersectionality, a belief that phenomena cannot be linked to one principal cause but instead an interconnected web of influences, in order to synthesize the multitude of factors believed …

The Role Of A-Layer In Polyunsaturated Fatty Acid (Pufa)-Mediated Effects On Aeromonas Salmonicida Subsp. Salmonicida, Allen Lin

Honors Theses

Aeromonas salmonicida subsp. salmonicida is a Gram-negative bacterium that infects salmonids and non-salmonids worldwide leading to an infection known as furunculosis, which is characterized by skin lesions and hemorrhages of the fish epidermis. This infection is carried out by a A+ (virulent strain) of A. salmonicida containing an important virulent factor known as the A-layer, which is a 2D paracrystalline structure that binds to the basement membrane and functions to promote adherence to host membranes and resistance to host defense. The purpose of this study was to examine the ability of the A+ A. salmonicida to incorporate exogenous fatty acids …