Digital Commons Network^™

National Science Foundation Awards University Of Dayton Researchers $201k To Investigate Massive Algae Blooms In Warming Arctic Ocean, Dave Larsen

College of Arts and Sciences Newsroom

The National Science Foundation awarded two University of Dayton researchers a grant to model critical changes in Arctic sea ice to detect and predict the growth and movement of large algae blooms in the Arctic Ocean, related to that region’s warming climate.

Therapeutic Potential Of Psychedelic Drugs, Specifically Magic Mushrooms, Marijuana, And Mdma With Veterans Who Suffer From Post-Traumatic Stress Disorder (Ptsd), Misty Schutterle

Counselor Education Capstones

Post-Traumatic Stress Disorder (PTSD) is a stress-based condition that a person develops after being exposed to an overwhelmingly traumatic event. Military troops frequently experience stress and trauma, making them highly susceptible to psychopathology. This paper evaluates nine clinical trials that used either magic mushrooms, marijuana, or MDMA as an adjunct to traditional psychotherapy to treat veterans who suffer from anxiety, depression, PTSD, suicidality, and other psychopathologies. Multiple scholarly journals and articles were read and analyzed, which show support for the therapeutic potential of psychedelic drugs in treating veterans with PTSD. After receiving psychedelic-assisted psychotherapy, the research showed participants experienced a …

A Na+/K+ Atpase Pump Regulates Chondrocyte Differentiation And Bone Length Variation In Mice, Marta Marchini, Mitchell R. Ashkin, Melina Bellini, Margaret Man Ger Sun, Matthew Lloyd Workentine, Hamza Malik Okuyan, Roman Krawetz, Frank Beier, Campbell Rolian

Paediatrics Publications

The genetic and developmental mechanisms involved in limb formation are relatively well documented, but how these mechanisms are modulated by changes in chondrocyte physiology to produce differences in limb bone length remains unclear. Here, we used high throughput RNA sequencing (RNAseq) to probe the developmental genetic basis of variation in limb bone length in Longshanks, a mouse model of experimental evolution. We find that increased tibia length in Longshanks is associated with altered expression of a few key endochondral ossification genes such as Npr3, Dlk1, Sox9, and Sfrp1, as well reduced expression of Fxyd2, a facultative subunit of the cell …

Comparison Of The Transcriptomic Signatures In Pediatric And Adult Cml, Minyoung Youn, Stephanie M. Smith, Alex Gia Lee, Hee-Don Chae, Elizabeth Spiteri, Jason Erdmann, Ilana Galperin, Lara Murphy Jones, Michele Donato, Parveen Abidi, Henrique Bittencourt, Norman Lacayo, Gary Dahl, Catherine Aftandilian, Kara L. Davis, Jairo A. Matthews, Steven M. Kornblau, Min Huang, Nathan Sumarsono, Michele S. Redell, Cecilia H. Fu, I-Ming Chen, Todd A. Alonzo, Elizabeth Eklund, Jason Gotlib, Purvesh Khatri, E Alejandro Sweet-Cordero, Nobuko Hijiya, Kathleen M. Sakamoto

Pathology Research and Scholarship

Children with chronic myeloid leukemia (CML) tend to present with higher white blood counts and larger spleens than adults with CML, suggesting that the biology of pediatric and adult CML may differ. To investigate whether pediatric and adult CML have unique molecular characteristics, we studied the transcriptomic signature of pediatric and adult CML CD34+ cells and healthy pediatric and adult CD34+ control cells. Using high-throughput RNA sequencing, we found 567 genes (207 up- and 360 downregulated) differentially expressed in pediatric CML CD34+ cells compared to pediatric healthy CD34+ cells. Directly comparing pediatric and adult CML CD34+ cells, 398 genes (258 …

Student Engagement In The Honors Biology Flipped Learning Environment, Hillary M. Wilson

Doctor of Education in Instructional Technology Dissertations

The purpose of this study was to investigate four constructs of engagement (affective, behavioral, cognitive, and social) within an Honors Biology flipped learning environment. Social constructivism, the Bioecological Model of Influences on Student Engagement, and Academic Communities of Engagement (ACE) served as the theoretical foundation for the study. A mixed methods convergent parallel design was used to answer the following research questions: What are student perceptions of engagement in a flipped learning environment based on the dimensions of engagement (e.g., affective, behavioral, cognitive, and social)? How do high school Honors biology students affectively, behaviorally, cognitively, and socially engage during the …

Stick It: The Lasting Experiences Of Gymnasts, Jason Gibbons

Final Projects

About the experiences of gymnasts. This paper highlights the importance of mindful coaching tactics and comradery in the face of difficult situations.

Bet You Won't Guess My Middle Name: Middle Name Customs In Lds Culture, Kayla Rane

Final Projects

About the Latter-day Saint tradition of withholding a daughter's middle name. Includes interviews about women who legally adopted their maiden name as a middle name upon marriage.

Polatuzumab Vedotin In Previously Untreated Diffuse Large B-Cell Lymphoma, Hervé Tilly, Neha Mehta-Shah, Et Al

Open Access Publications

BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is typically treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). However, only 60% of patients are cured with R-CHOP. Polatuzumab vedotin is an antibody-drug conjugate targeting CD79b, which is ubiquitously expressed on the surface of malignant B cells.

METHODS: We conducted a double-blind, placebo-controlled, international phase 3 trial to evaluate a modified regimen of R-CHOP (pola-R-CHP), in which vincristine was replaced with polatuzumab vedotin, as compared with standard R-CHOP, in patients with previously untreated intermediate-risk or high-risk DLBCL. Patients 18 to 80 years of age were randomly assigned in a 1:1 ratio to …

Active Targeting Of Estrogen Receptor (Er)-Positive Breast Cancer Cells Using Nanotechnology, Molly White

Theses and Dissertations

The American Cancer Society has predicted an estimated 281,550 new invasive breast cancer cases for 2021. Chemotherapy is one of the main options available to treat this disease, but it can result in drug resistance and harmful side effects, as traditional methods do not directly target the cancer cells. To address this issue, nano formulations have been widely researched for targeted delivery of anticancer drugs. The primary objective of this project was to develop a novel nanodrug, rapamycin-loaded gold nanorods functionalized with polyethylene glycol and epithelial cell adhesion molecule (EpCAM), to selectively target breast cancer cells. The work involved characterizing …

Keragaman Genetik Koleksi Plasma Nutfah Jewawut Sister Line Dan Lokal Menggunakan Marka Ssr, Karlina Syahruddin, Muhammad Azrai, Marcia Bunga Pabendon, Muhammad Abid, Amin Nur

Jurnal Kultivasi

Keragaman genetik sangat penting dalam pemuliaan tanaman, oleh karena itu informasi genetik sangat dibutuhkan dalam proses seleksi. Teknologi molekuler dengan menggunakan marka Simple Sequence Repeat (SSR) saat ini banyak digunakan karena keakuratan informasi dan polimorfik untuk spesies atau galur yang berkerabat dekat. Penelitian ini dilakukan untuk mengidentifikasi keragaman genetik dari 14 koleksi plasmanutfah jewawut berkerabat dekat dengan menggunakan 27 marka SSR yang menyebar pada semua kromosom jewawut. Hasil penelitian menunjukkan bahwa koleksi plasmanutfah jewawut berkerabat dekat mengelompok pada klaster yang sama, kecuali pada koleksi aksesi Wete dari Nusa Tenggara Timur (NTT) yang menyebar pada kelompok yang berbeda pada kisaran nilai …

Microfluidic-Coupled In Vitro Model Of The Blood-Brain Barrier, Subhra Mohapatra, Shyam S. Mohapatra, Tao Wang, Taylor Martinez

USF Patents

An in vitro microfluidic device includes a device configured to model a blood-brain barrier. The device includes a center well in fluidic communication with each of an inlet and an outlet. Each of the center well, inlet, and outlet includes a porous membrane that separates a “blood” portion (a fluid flow portion) from a “brain” portion (a fluid containing portion). The porous membrane is seeded with endothelial cells such as the human venule endothelial cells (HUVECs) on the blood side, and with astrocytes on the brain side, to accurately model the blood-brain barrier. Fluid flows between the inlet, the center …

Electron Microscope Images Of Human Coronaviruses Reality Versus Illusion, Mohamed Ayman Ghallab, Christine Barsoum, Stefan Polak, Olia El Hassoun, Ayman Ghallab

Dentistry

ABSTRACT Since the outbreak of COVID-19 as a pandemic disease earlier in 2020, several publications reported the electron microscope images of SARS-CoV-2. This article reviews 73 articles from March 1956 till April 2021, focusing on the ultrastructure characteristics of the viruses. We present the scientifi c debate and provide an opinion on the current controversy of electron microscopic images interpreted as SARS-CoV-2 particles in specimens from patients with COVID-19. Finally, we report our fi ndings in a post-mortem lung specimen of a COVID-19 patient. With this we hope to facilitate accurate interpretation of TEM fi ndings, and contribute to the …

A Comparison Of The Risk Of Fracture In Rheumatoid Arthritis Patients With And Without Receiving Chinese Herbal Medicine, Hou-Hsun Liao, Hanoch Livneh, Yu-Jung Chung, Ching-Hsing Lin, Ning-Sheng Lai, Hung-Rong Yen, Tzung-Yi Tsai

Counselor Education Faculty Publications and Presentations

Objective: Patients with rheumatoid arthritis (RA) often suffer from bone complications due to persistent joint inflammation, especially incident fracture. Nowadays, Chinese herbal medicines (CHMs) have provided safe and effective therapy for treating skeletal conditions, but it is unclear whether CHMs can prevent fracture onset among RA individuals. This study aimed to determine the association between the use of CHMs and the risk of fracture among them.

Methods: This retrospective, population-based study retrieved administrative health data from the Taiwan National Health Insurance (NHI) database to identify patients with newly diagnosed RA between 2000 and 2009. Of the 6178 incident …

Disinheritance, Discrimination, And The Case For Including Adult Independent Children In Dependants’ Relief Schemes: Lawen Estate V Nova Scotia, Jane Thomson

Dalhousie Law Journal

In 2019 a Superior Court in Nova Scotia excluded adult independent children as “Dependants” under Nova Scotia’s Testator’s Family Maintenance Act. The decision was based on a finding that testamentary autonomy is a constitutional right protected by s. 7 of Canada’s Charter of Rights and Freedoms. This article explains why the constitutional decision in Lawen Estate v Nova Scotia was incorrect. It also demonstrates why the inclusion of adult independent children in dependants’ relief schemes is not only benign in most instances, but may play a role in preventing the perpetuation of discrimination in the private law. This article also …

Review Of Psychology As A Biological Science, Angela M. Mar

Open Educational Resources - Reviews

No abstract provided.

Complementary Or Alternative Medicine Usage Of Mothers Seeking To Prevent Coronavirus Illness Or Manage Symptoms: Identifying Relationships Existing Between Mental Constructs And Concepts Of The Health Belief Model, Gabrielle Frachiseur

Health and Kinesiology Theses

Background: Mothers are the central supportive structure in most households. Mothers can become overwhelmed by informational overload when selecting the most appropriate modalities of care to provide for their families during the pandemic. The researcher sought to discover the prevalence of complementary or alternative medicine usage (CAM) for the prevention of coronavirus illness or symptoms management. Additionally, the researcher sought to identify the relationship between three additional mental constructs; knowledge, attitudes and beliefs, and constructs of the Health Belief Model, that could affect CAM adoption.

Methods: A cross-sectional survey was dispersed to 5 private Facebook groups. The survey was targeted …

Public Opinion And Knowledge Of Marine Biodiversity In A Coastal Community - Horry County, South Carolina, Arianna R. Trapp

Honors Theses

There is very little research that explores the public attitude toward marine biodiversity loss as an environmental issue. This study aims to provide insight into the disparities in marine conservation education in order to better provide meaningful education opportunities for coastal communities. The data for this research was collected using a series of semi-structured interviews that were conducted as focus groups of participants from Horry County, South Carolina. Residents from North Myrtle Beach, Myrtle Beach, Loris, and Bucksport were recruited to three focus groups based on their geographical residency. Horry County retirees and students attending Coastal Carolina University were also …

Revised Semiempirical Approach To Predict The Occurrence Of Twinning In Titanium Alloys, Chirag Dhirajlal Rabadia, Syed Faraz Jawed, Jincheng Wang, Milind Siddhpura, Arti Siddhpura

Research outputs 2014 to 2021

A revised semiempirical approach, considering the average values of the valence electron to atom ratio (e/a̅) and a difference in atomic radii of alloying element/s and the base element (Δr¯), is proposed to predict the twin formation in titanium alloys. The revised e/ā versus Δr¯ diagram is plotted, considering the reported results of 90 titanium alloys fabricated using various processing methods. A new twin/slip boundary has been plotted and recommended based on the revised e/ā versus Δr¯ diagram. The conventional maximum limit reported for the twinning in titanium alloys is e/ā = 4.20; however, it has been found that twinning …

Dietary Power And Self-Determination Among Female Farmers In Burkina Faso: A Proposal For A Food Consumption Agency Metric, Zoe Tkaczyk

Geography Honors Projects

While food security is traditionally defined with four pillars, there are increasing calls for an additional two (agency and sustainability) so that we may more comprehensively conceptualize all dimensions of food security. However, the challenge is that it is difficult to effectively measure agency, a person’s control over their food system. Measuring women’s agency is especially critical in Africa South of the Sahara where women play prominent roles in farming and food preparation. This honors thesis explores the feasibility of creating a metric to measure agency within food systems and gender relations using data related to food security and dietary …

Lipid A-Ara4n As An Alternate Pathway For (Colistin) Resistance In Klebsiella Pneumonia Isolates In Pakistan, Kiran I. Masood, Seema Umar, Zahra Hasan, Joveria Farooqi, Safina Abdul Razzak, Nazish Jabeen, Jason Rao Jason Rao, Sadia Shakoor, Rumina Hasan

Department of Pathology and Laboratory Medicine

Objectives: This study aimed to explore mechanism of colistin resistance amongst Klebsiella pneumoniae isolates through plasmid mediated mcr-1 gene in Pakistan. Carbapenem and Colistin resistant K. pneumoniae isolates (n = 34) stored at - 80 °C as part of the Aga Khan University Clinical Laboratory strain bank were randomly selected and subjected to mcr-1 gene PCR. To investigate mechanisms of resistance, other than plasmid mediated mcr-1 gene, whole genome sequencing was performed on 8 clinical isolates, including 6 with colistin resistance (MIC > 4 μg/ml) and 2 with intermediate resistance to colistin (MIC > 2 μg/ml).
Results: RT-PCR conducted revealed absence of …

A Link Between Methylglyoxal And Heart Failure During Hiv-1 Infection, Prasanta K. Dasg, Fadhel A. Alomar, Jesse L. Cox, Joellyn Mcmillan, Bryan T. Hackfort, Edward Makarov, Brenda Morsey, Howard S. Fox, Howard E. Gendelman, Santhi Gorantla, Keshore R. Bidasee

Department of Biochemistry: Faculty Publications

Early-onset heart failure (HF) continues to be a major cause of morbidity and mortality in people living with human immunodeficiency virus type one (HIV-1) infection (PLWH), yet the molecular causes for this remain poorly understood. Herein NOD.Cg- Prkdc^scidIl2rg^tm1Wjl/SzJ humanized mice (Hu-mice), plasma from PLWH, and autopsied cardiac tissues from deceased HIV seropositive individuals were used to assess if there is a link between the glycolysis byproduct methylglyoxal (MG) and HF in the setting of HIV-1 infection. At five weeks post HIV infection, Hu-mice developed grade III-IV diastolic dysfunction (DD) with an associated two-fold increase in plasma …

Tisagenlecleucel Immunogenicity In Relapsed/Refractory Acute Lymphoblastic Leukemia And Diffuse Large B-Cell Lymphoma., Karen Thudium Mueller, Stephan A. Grupp, Shannon L. Maude, John E. Levine, Michael A. Pulsipher, Michael W. Boyer, Keith August, Douglas Myers, Constantine S. Tam, Ulrich Jaeger, Stephen Ronan Foley, Peter Borchmann, Stephen J. Schuster, Edmund K. Waller, Rakesh Awasthi, Bernd Potthoff, Andy Warren, Edward R. Waldron, Fraser Mcblane, Andrea Chassot-Agostinho, Theodore W. Laetsch

Manuscripts, Articles, Book Chapters and Other Papers

Tisagenlecleucel is indicated for pediatric and young adult patients with relapsed/refractory (r/r) B-cell acute lymphoblastic leukemia (B-ALL) and adult patients with r/r diffuse large B-cell lymphoma (DLBCL). The tisagenlecleucel chimeric antigen receptor (CAR) contains a murine single-chain variable fragment domain; we examined the effects of humoral and cellular immune responses to tisagenlecleucel on clinical outcomes using 2 validated assays. Data were pooled from the ELIANA (registered at www.clinicaltrials.gov as #NCT02435849) and ENSIGN (#NCT02228096) trials in r/r B-ALL (N = 143) and the JULIET trial (#NCT02445248) in r/r DLBCL (N = 115). Humoral responses were determined …

"All For The Family:" A Case Study On The Migration Of Philippine Educated Nurses To Ontario Through The Live-In Caregiver Program, Oluwabukola Oladunni Salami

Dissertations

Despite evidence that suggests that nurses migrate to Ontario through the Live-in Caregiver Program, no research has been conducted on this group of nurses in Ontario. This study addresses that gap utilizing the transnational feminist concept of "global care chains" in a single holistic case study design to explore the experience of nurses who migrate to Ontario through the Live-in Caregiver Program (2001-2011), and examine the diverse perspectives of stakeholders on issues of rights and obligations of these nurses. Fifteen live-in caregivers and nine policy stakeholders were interviewed, and an analysis undertaken of immigration and nursing policy documents. Findings indicate …

Nanoparticles And Photochemistry For Native-Like Transmembrane Protein Footprinting, Jie Sun, Xiaoran Roger Liu, Shuang Li, Peng He, Weikai Li, Michael L Gross

Open Access Publications

Mass spectrometry-based footprinting can probe higher order structure of soluble proteins in their native states and serve as a complement to high-resolution approaches. Traditional footprinting approaches, however, are hampered for integral membrane proteins because their transmembrane regions are not accessible to solvent, and they contain hydrophobic residues that are generally unreactive with most chemical reagents. To address this limitation, we bond photocatalytic titanium dioxide (TiO

Early Relapse Identifies Mcl Patients With Inferior Survival After Intensive Or Less Intensive Frontline Therapy, David A. Bond, Mary-Kate Malecek, Brad S. Kahl, Et Al

Open Access Publications

No abstract provided.

Bleeding Assessment Tools In The Diagnosis Of Vwd In Adults And Children: A Systematic Review And Meta-Analysis Of Test Accuracy, Mohamad A. Kalot, Jorge Di Paola, Et Al

Open Access Publications

No abstract provided.

Pengaruh Cara Pemberian Pupuk Npk Dan Frekuensi Pemberian Paklobutrazol Terhadap Pertumbuhan Dan Hasil Benih Kentang G0 Di Dataran Medium, Jajang Sauman Hamdani, Sumadi, Kusumiyati, Syariful Mubarok

Jurnal Kultivasi

Produksi benih kentang (Solanum tuberosum L) di dataran medium dapat menjadi pilihan untuk menghindari kerusakan lingkungan dan terbatasnya areal untuk produksi benih kentang di dataran tinggi. Salah satu upaya untuk peningkatan produksi benih kentang generasi ke-0 (G0) adalah pemberian pupuk NPK dan zat pengatur tumbuh. Sehubungan hal tersebut, maka perlu dilakukan kajian cara pemberian pupuk NPK dan frekuensi pemberian paklobutrazol yang tepat untuk meningkatkan pertumbuhan dan hasil benih kentang G0 di dataran medium. Percobaan ini bertujuan untuk mengetahui interaksi antara cara pemberian pupuk NPK dan frekuensi pemberian paklobutrazol yang dapat meningkatkan pertumbuhan dan hasil benih kentang G0 di dataran medium. …

Uji Aktivitas Protease Empat Isolat Trichoderma Spp. Yang Berasal Dari Tanah Perakaran, Fitria Dewi Sulistiyono, Loekas Soesanto, Nuniek Ina Ratnaningtyas

Chimica et Natura Acta

Perkembangan industri protease telah pesat dan menempati posisi penting dalam bidang industri. Protease dapat diperoleh dari semua mahluk hidup, namun saat ini pemakai enzim banyak yang beralih pada enzim mikrobioal. Keunggulan enzim microbial adalah produksi tinggi, kemudahan dan efisiensi dalam pengaturan pertumbuhan, limbah pertanian dapat dimanfaatkan sebagai sumber substrat. Salah satu mikroba adalah Trichoderma spp. Trichoderma sp dapat berasal dari tanah perakaran tanaman (rhizosfer). Jenis tanah perakaran diantarnya adalah jahe, nenas, pisang dan bawang merah. Keempat tanaman ini merupakan tanaman yang banyak dibudidayakan oleh masyarakat. Tujuan penelitian ini adalah menentukan jumLah protease yang terdapat pada Trichoderma spp. Metode penelitian dilakukan …

Studi In Silico Gadolinium(Iii)-Diethylene Triamine Pentaacetic Acid-Folat Dan Modifikasinya Terhadap Reseptor Folat Sebagai Senyawa Pengontras Untuk Deteksi Kanker, Muhammad Yusuf, Bayu Shiddiq Widhi Pratama, Umi Baroroh, Shabarni Gaffar, Ukun M.S. Soedjanaatmadja

Chimica et Natura Acta

Tumor ganas atau kanker merupakan salah satu masalah utama kesehatan di dunia.  Pendeteksian dini sel kanker dengan menggunakan Magnetic Resonance Imaging (MRI) memungkinkan penanganan yang lebih baik. Pemilihan senyawa kontras yang tepat dapat meningkatkan akurasi diagnosa terhadap penyakit kanker. Sel kanker banyak mengekspresikan reseptor folat α yang mampu mengikat asam folat dalam tubuh. Penambahan asam folat ke dalam senyawa pengontras Gadolinium (III)-diethylene triamine pentaacetic acid (Gd-DTPA) berguna untuk meningkatkan spesifisitas diagnostik sel kanker. Penelitian ini bertujuan untuk mengetahui interaksi senyawa pengontras dengan molekul target reseptor folat α dengan penambatan molekul dan simulasi dinamika molekul (MD). Struktur Gd-DTPA-folat dimodelkan dari struktur …

Effects Of Tendon Viscoelasticity On The Distribution Of Forces Across Sutures In A Model Tendon-To-Bone Repair, Yuxuan Huang

McKelvey School of Engineering Graduate Student Theses & Dissertations

Tears to the rotator cuff often require surgical repair. These repairs often culminate in re-tearing when sutures break through the tendon in the weeks following repair. Numerous studies have been performed to identify suturing strategies that reduce this risk by balancing forces across sutures. However, the structural engineering basis for these approaches is still emerging, and the effects of tendon mechanics on load balancing is still unclear. Specifically, the effects of the viscoelastic nature of tendon on load sharing have not been established. With the aim of providing insight into this problem, this thesis studies how tendon viscoelasticity, tendon stiffness, …