Digital Commons Network^™

Glial Dysfunction And Its Contribution To The Pathogenesis Of The Neuronal Ceroid Lipofuscinoses, Keigo Takahashi, Hemanth R Nelvagal, Jenny Lange, Jonathan D Cooper

2020-Current year OA Pubs

While significant efforts have been made in developing pre-clinical treatments for the neuronal ceroid lipofuscinoses (NCLs), many challenges still remain to bring children with NCLs a cure. Devising effective therapeutic strategies for the NCLs will require a better understanding of pathophysiology, but little is known about the mechanisms by which loss of lysosomal proteins causes such devastating neurodegeneration. Research into glial cells including astrocytes, microglia, and oligodendrocytes have revealed many of their critical functions in brain homeostasis and potential contributions to neurodegenerative diseases. Genetically modified mouse models have served as a useful platform to define the disease progression in the …

Cryogel Scaffold-Mediated Delivery Of Adipose-Derived Stem Cells Promotes Healing In Murine Model Of Atrophic Non-Union, Katherine R Hixon, Dakota B Katz, Jennifer A Mckenzie, Anna N Miller, Farshid Guilak, Matthew J Silva

2020-Current year OA Pubs

Non-union is defined as the permanent failure of a bone to heal and occurs clinically in 5% of fractures. Atrophic non-unions, characterized by absent/minimal callus formation, are poorly understood and difficult to treat. We recently demonstrated a novel murine model of atrophic non-union in the 3.6Col1A1-tk (Col1-tk) mouse, wherein dosing with the nucleoside analog ganciclovir (GCV) was used to deplete proliferating osteoprogenitor cells, leading to a radiographic and biomechanical non-union after the mid-shaft femur fracture. Using this Col1-tk atrophic non-union model, we hypothesized that the scaffold-mediated lentiviral delivery of doxycycline-inducible BMP-2 transgenes would induce osteogenesis at the fracture site. Cryogel …

Social Disorganisation Theory And Violent Crime: A Spatial-Econometric Analysis Of Chicago And Sydney, Anthony N. Greening

Theses: Doctorates and Masters

The spatialisation of violent crime is explored in two large case studies, Chicago and Sydney, using spatial econometric methods and macro-sociological variables derived from Social Disorganisation Theory.

Social Disorganisation Theory (SDT) is introduced in terms of its formulation in response to highly specific conditions arising in Chicago, as well as its adoption of methodological and theoretical developments from existing traditions. This specificity belies its breadth of application and enduring presence in criminology. With “Social Disorganisation Theory” hosting a wealth of highly nuanced academic dialogue conducted under its banner, current incarnations of SDT appear as branches on an evolutionary tree. This …

A Privacy Preserving Online Learning Framework For Medical Diagnosis Applications, Trang Pham Ngoc Nguyen

Theses: Doctorates and Masters

Electronic Health records are an important part of a digital healthcare system. Due to their significance, electronic health records have become a major target for hackers, and hospitals/clinics prefer to keep the records at local sites protected by adequate security measures. This introduces challenges in sharing health records. Sharing health records however, is critical in building an accurate online diagnosis framework. Most local sites have small data sets, and machine learning models developed locally based on small data sets, do not have knowledge about other data sets and learning models used at other sites.

The work in this thesis utilizes …

Russian Logics And The Culture Of Impossible: Part Ii: Reinterpreting Algorithmic Rationality, Ksenia Tatarchenko, Anya Yermakova, Liesbeth De Mol

Research Collection School of Social Sciences

This article reinterprets algorithmic rationality by looking at the interaction between mathematical logic, mechanized reasoning, and, later, computing in the Russian Imperial and Soviet contexts to offer a history of the algorithm as a mathematical object bridging the inner and outer worlds, a humanistic vision that we, following logician Vladimir Uspensky, call the “culture of the impossible.” We unfold the deep roots of this vision as embodied in scientific intelligentsia. In Part I, we examine continuities between the turn-of-the-twentieth-century discussions of poznaniye—an epistemic orientation towards the process of knowledge acquisition—and the postwar rise of the Soviet school of mathematical logic. …

The Lives Of Late Soviet Science, 1945-1991, Grégory Dufaud, Ksenia Tatarchenko

Research Collection College of Integrative Studies

This study explores the multifaceted landscape of Soviet science from the end of World War II to the dissolution of the USSR in 1991. It examines the interplay between scientific innovation and political ideology, highlighting how the state shaped research agendas and scientific practices during a period marked by both significant achievements and profound challenges. Through an analysis of key scientific institutions, prominent figures, and pivotal projects, the study illustrates the tensions between ideological constraints and the pursuit of knowledge. Additionally, it addresses the impacts of international collaboration and competition during the Cold War, revealing how these dynamics influenced scientific …

Revision Total Hip Femoral Stem Micromotion And Statistical Shape Modeling Of The Knee, William Fugit

Electronic Theses and Dissertations

The first purpose of this thesis was to compare the amount of micromotion seen in the femoral stem in a revision total hip arthroplasty between simple loading conditions and loading conditions derived from activities of daily living, through the use of experimental and computational methods. The amount of micromotion at the bone-implant interface was larger for activities of daily living, with ranges of 200μm more than the largest simple loading conditions. The second purpose of this thesis was to compare measurements of accuracy in a statistical shape model between individual bone and joint-level models, specifically for the knee. Using computational …

Design Of Human Inspired Feet For Mithra, A High-Performance Humanoid Robot, Spencer Lyle Brewster

Electronic Theses and Dissertations

This thesis explores the foot design for the new humanoid robot Mithra, with the goal to improve impact mitigation, natural gait throughout the gait cycle and balance. Using human gait parameters, a stiff aluminum foot was designed to emulate human center of pressure rollover trajectories. In addition, a 2D dynamic Finite Element Analysis (FEA) of the gait cycle was created in Abaqus to rapidly prototype foot designs. Data from the FE model provided impact forces, parameters for distal foot power evaluation and maximum lean angles. From this model a flexible nylon foot was optimized for the given design objectives. The …

Juntos Luchamos: A Postcritical Ethnographic And Photovoice Study On Latinx Student Civic Engagement Practices At A Hispanic-Serving Institution, Liliana Diaz

Electronic Theses and Dissertations

Situated at a Hispanic-Serving Institution (HSI), this postcritical ethnographic and photovoice study sought to explore how Latinx students define and practice civic engagement. Theoretically framed by Latino Cultural Citizenship (LCC), the study explored how current Latinx student civic engagement practices inform a Hispanic-Serving Institutions’ civic engagement efforts. Data collection took place over the 2021-2022 academic year and an exhibition of the study’s findings was made publicly available at the culmination of the study. Findings from the study indicate that Latinx postsecondary students define civic engagement as knowledge and resource sharing (KRS) and achieving success. Findings for how Latinx postsecondary students …

Machine Learning Approaches To Improve Prediction In Health Care, Sadaf Kabir

Graduate Theses, Dissertations, and Problem Reports (ETD)

The availability of data and advanced data analysis tools in the health care domain provide great opportunities for the discovery of unknown or hidden patterns in clinical data. However, medical data is often incomplete and has poor quality, e.g., it contains missing values or too many unnecessary features. Majority of these issues are induced by uncertainty in clinical trials and examinations, such as human error, patients’ withdrawal during studies, malfunctioning of data collection equipment, and are generally inevitable. Properly addressing these issues can lead to the development of precise predictive models and consequently more reliable clinical decision making. Accurate predictive …

A Tool For Biometric Interpretation Of Forensic Str Dna Profiles, Ahmad Jamal Baroudi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Rapid DNA biometric identification applications are becoming more essential and widely used in human identity validation processes. Despite their powerful identification capabilities, processing a sample to generate a forensic DNA profile still takes longer compared with other rapid biometric technologies. Methods used to speed up the analysis could lead to signal artifacts similar to those arising from low copy or degraded DNA samples, making the electropherogram unsuitable for forensic interpretation and analysis. The goal of this research effort is to apply biometrics and mathematical approaches to forensic STR (Short Tandem Repeat) profiles. To accomplish this goal, a multi-function software tool …

Survival Rate Of Dental Implants Placed In Alveolar Ridge Preservation Sites - Systematic Review, Sravanthi Papisetti

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: It is not known so far performing Alveolar Ridge Preservation (ARP) in a freshly extracted socket with intact walls would improve clinical outcomes of implants placed in these sites. It is not known whether different biomaterials and techniques would affect the survival of dental implants.

Aim: The current systematic review is undertaken to assess the survival rate of dental implants placed in these sockets and to assess different socket graft materials as well as techniques of ridge preservation with regard to the survival of implants.

Material methods: Search for relevant articles was done in Medline (PubMed). No …

Factors Influencing Brook Trout Population Dynamics And Resilience In Central Appalachian Headwater Streams, Christopher W. Schwinghamer

Graduate Theses, Dissertations, and Problem Reports (ETD)

Central Appalachia has a unique history of human perturbation due largely to its historical economic reliance on extractive industry and timber harvest. Legacy impacts from these historic disturbances along with contemporary stressors in the form of continued industry, changing climates, altered land use, habitat fragmentation, and introduced species can present great threats to the region’s aquatic ecosystems. Brook Trout Salvelinus fontinalis are a species that has recreational and economic importance to the communities of central Appalachia but declines in size and abundance have been observed. Given the disturbances that threaten Brook Trout populations, understanding how their populations will respond to …

Population And Migratory Ecology Of Canada Warblers (Cardellina Canadensis) In The Central Appalachian Mountains, West Virginia, Usa, Stephanie H. Augustine

Graduate Theses, Dissertations, and Problem Reports (ETD)

Nearctic-Neotropical migrant birds experience a wide range of environmental conditions throughout their annual cycle; thus, it is particularly challenging to evaluate the spatial factors that may influence population growth. The Canada Warbler (Cardellina canadensis) faces substantial range-wide population declines, but little study has been conducted regarding elements occurring across the entire year that drive demographic rates. The aims of this research are (1) determine the relationship between Canada Warbler population demographic rates and environmental conditions along an elevation gradient in the central Appalachian Mountains and (2) ascertain the nonbreeding season location and migratory routes used by the central …

Learning Mathematics While Black In Rural Appalachia: Black Students' Counterstories And Freedom Dreams About Mathematics Education, Sean P. Freeland

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation aims to illuminate and uncover the experiences of Black students’ learning mathematics in rural Appalachia and specifically West Virginia. The focal theory for this study is Critical Race Theory (CRT) which centers the experience of Black students and their voices. The intersection of race, mathematics education, and the context of rural Appalachia contribute to the analysis of these experiences in specific ways. Participants for this study included six Black high school students from various communities throughout West Virginia. Through interviews and mathematical autobiographies, these students shared their experiences learning mathematics across their schooling experiences and also considering their …

Extension Of A Bayesian Method For Viral Genome Re-Sequencing To Multi-Dimensional Parameters, Sarah Fleischer

Graduate Theses, Dissertations, and Problem Reports (ETD)

Next Generation Sequencing (NGS) refers to all sequencing methods post Sanger Sequencing. Sequencing By Synthesis is the most well-known method, however it’s inaccessible price is difficult for some. Thus, a different method also exists, re-sequencing– which relies on a reference genome to check the validity of each base call. The standard for determining the validity of a base call is a one parameter quality score. But, previously a two-parameter Bayesian method was successfully used for re-sequencing the viral genome. However, a quality parameter was previously not used in the construction of the cumulative density function for the likelihood. This paper …

Influence Of Saturation Nonequilibrium And Variable Operation Conditions On The Electromechanical Performance Of Ionic Polymer Metal Composite Actuator Architectures, Allison Maria Arnold

Graduate Theses, Dissertations, and Problem Reports (ETD)

Electroactive polymers (EAPs) continue to gain attention for their potential to offer unique and versatile solutions in the soft robotic and flexible electronic industries. Ionic Polymer-Metal Composites (IPMCs) are a class of ionic-type EAPs which can be configured as capacitor actuators with very low voltage requirements (≤ 5 V AC or DC). Their compact, portable, and lightweight properties, coupled with a biomimetic bending actuation response make them ideal for human-machine integrated technologies such as medical implants, active skins, and artificial muscles. The Nafion-based IPMC can be described as a layered composite capacitor containing an ionic polymer core, sandwiched between chemically …

A Shock To The System: Analyzing Ethnocentric Populist Support Before And After Crises, Kyu Chul Shin

Graduate Theses, Dissertations, and Problem Reports (ETD)

Using the question of what is driving the support for populists in the mid-late 2010s in Western Europe and the United States as the starting point, this dissertation attempts to answer a number of different questions related to populists: Were the reasons behind support for populists in countries that saw an increase in support for populisms similar to those that saw a decrease in support? Are the reasons for supporting right-wing populists different from more general ethnocentric populists? Are the reasons that Americans supported Donald Trump similar or different from the reasons behind support for Western European populists? Following migration-related …

Sleep And Cardiovascular Reactivity To An Acute Virtual Stressor, Alaina Grace Tiani

Graduate Theses, Dissertations, and Problem Reports (ETD)

Inappropriate response and magnitude of cardiovascular reactivity (CVR) to stress is a proposed mechanism through which environmental stressors are linked with poor cardiovascular health outcomes (Chida & Steptoe, 2010; Krantz & Manuck, 1984). Studies of reactivity to various laboratory tasks commonly control for factors known to influence CVR such as smoking, medication use, caffeine intake, and BMI; however, few have considered the influence of sleep on CVR. In order to determine whether sleep characteristics need to be assessed and considered in studies of CVR, this study aimed to examine the association between indices of sleep quality and the magnitude and …

Development Of Capillary Vibrating Sharp-Edge Spray Ionization For Improving Continuous Flow Mass Spectrometry Analysis, Chong Li

Graduate Theses, Dissertations, and Problem Reports (ETD)

Capillary Vibrating Sharp-Edge Spray Ionization (cVSSI) is new ionization technique developed in the year of 2018. This ionization technique has attractive features such as simplicity, compactness, ease of manipulation, low costs, compatible with continuous flow, etc. However, the development of high performance cVSSI for mass spectrometry analysis is a process that needs unremitting optimizations. In this dissertation, I demonstrate the development of cVSSI for improving continuous flow mass spectrometry analysis. The chapter 2 focuses on improving the ionization efficiency of cVSSI through reducing the droplet size. Three strategies were tested to reduce the droplet size of VSSI. The most effective …

Genetic Analysis And Telemetry Study Of Migration Habits Of The Endangered Atlantic Sturgeon, Cassia Marie Busch

Graduate Theses, Dissertations, and Problem Reports (ETD)

Atlantic sturgeon are a long-lived anadromous fish that ranged from Labrador, Canada to Florida, US. Due to overharvest in the late 1800’s and 1900’s, Atlantic sturgeon populations across the coast experienced a dramatic population crash. Recovery of this species has faced challenges due to anthropogenic threats, such as vessel strikes, bycatch, and habitat degradation. In 2012, Atlantic sturgeon were added to the United States Endangered Species Act (ESA). Under the ESA, populations were listed as five distinct population segments (DPS), reflecting their geographic arrangement and genetic structure: Gulf of Maine DPS (threatened), New York Bight DPS (endangered), Chesapeake DPS (endangered), …

The Contribution Of Artists Sydney Laurence, Belmore Browne, And Olaus Murie To The Preservation Of Public Land In The Northwest United States, Madelyn Brodie

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis analyzes the impact of artists Sydney Laurence (1856- 1940), Belmore Browne (1880- 1954), and Olaus Murie (1889- 1963) and the contribution that their artwork had to the conservation of United States public lands. This thesis examines the conservation initiatives that were brought into effect during the early 1900s, the personal motivations of these artists to preserve the land, and the interactions between these artists and the United States government which demonstrates their involvement in land preservation. The impact that the artists had on tourism which extended the conservation movement is also addressed. Artworks created by Laurence, Browne, and …

Optimization And Analytics Of Decarbonized Forest And Biomass Supply Chains, Xufeng Zhang

Graduate Theses, Dissertations, and Problem Reports (ETD)

First, a data-driven holistic analysis framework was developed to aid the industrial development of forest biomass for bioenergy to promote the regional bioeconomy. Leveraging the existing but fragmented multi-source data, four components of industrial bioenergy development were integrated into the framework including spatial statistical analysis of biomass feedstock and bioenergy production, machine learning-based suitability assessment, bioenergy plant sites identification and ranking, and socio-economic impacts assessment. A case study was conducted for forest biomass to pellet fuel in the U.S. Mid-Atlantic region. Our results indicate that the great potential of forest biomass with high variation at the county level is primarily …

Associations Between Self-Reported Awe And Heart Rate, Laura E. Bernstein

Graduate Theses, Dissertations, and Problem Reports (ETD)

Fredrickson’s (1998, 2013) broaden and build theory states that positive emotions can expand our social and cognitive awareness and provide health benefits. Some positive emotions, such as awe, may operate differently. We sought to understand how subjective reports of awe, induced through videos, correlate with HR. We know that HR tends to decrease with age (Umetani et al., 1998), individuals have less physiological reactivity as they age (Blanchard-Fields, 2007), and older adults report more positive emotions than negative emotions (Mroczek & Kolarz, 1998). Given these findings, we were interested in understanding whether there were age differences in self-reported awe and …

Performance Of Peltier Cooled Technology During Preconcentration Of Volatile Organic Compounds Analyzed By Gas Chromatography-Mass Spectrometry (Gc-Ms) Using Niosh Manual Of Analytical Methods (Nmam) 3900, Elizabeth Ann Fernandez

Graduate Theses, Dissertations, and Problem Reports (ETD)

Using evacuated canisters for whole-air sampling allows for sampling without specific knowledge of the environment and potential analytes. Evacuated canisters are able to tolerate concentrations ranging from parts per trillion (PPT) to parts per million (PPM). The U.S. Environmental Protection Agency (EPA) has used evacuated canisters for years to sample volatile organic compounds (VOCs) from ambient air using their method TO-15 (LeBouf, et al., 2019). The GC-MS system used for the development of NMAM 3900 used liquid nitrogen to cool sorbent traps in the preconcentrator. Liquid nitrogen allows for cooling of specified points below ambient temperature. An alternative to liquid …

Examining The Relationship Among Perceived Academic Climate, Belongingness, And Engineering Identity, Sumaia Ali Raisa

Graduate Theses, Dissertations, and Problem Reports (ETD)

An attempt to cultivate an inclusive learning environment in engineering is trending as a response to women's underrepresentation and a lower retention rate than men undergraduates. This study was situated in such an undergraduate engineering program where interventions were embedded in the course curriculum focusing on cultivating an inclusive engineering identity. Following a sociocultural perspective, the present study aimed to examine the relation of engineering identity with perceived academic climate, sense of belonging, and gender among two engineering cohorts (before covid and during covid context). A total of 482 first-year engineering undergraduates' survey responses were analyzed in this study using …

Development Of A Transition Program For Young Adults With Type 1 Diabetes Progressing From Pediatric To Adult Care – A Feasibility Study, Elizabeth Ann Minchau

Graduate Theses, Dissertations, and Problem Reports (ETD)

ABSTRACT

Development of a Transition Program for Young Adults with Type 1 Diabetes Progressing from Pediatric to Adult Care – A Feasibility Study

Elizabeth A. Minchau

Background: Emerging adulthood requires a delicate balance of the competing social, educational, occupational, and financial demands typical of this developmental stage. This time period presents special challenges for adolescents with type 1 diabetes (T1D), who must also prioritize consistent medical follow-up and ongoing intensive self-care. Emerging adults with T1D struggle with glycemic control that is further exacerbated by an often-times disorganized transfer of care between pediatric and adult endocrinology practices. Substantial gaps in care …

Development Of Computational Methods For Electronic Structural Characterization Of Strongly Correlated Materials: From Different Ab-Initio Perspectives, Uthpala K. Herath

Graduate Theses, Dissertations, and Problem Reports (ETD)

The electronic correlations in materials drive a variety of fascinating phenomena from magnetism to metal-to-insulator transitions (MIT), which are due to the coupling between electron spin, charge, ionic displacements, and orbital ordering. Although Density Functional Theory (DFT) successfully describes the electronic structure of weakly interacting material systems, being a static mean-field approach, it fails to predict the properties of Strongly Correlated Materials (SCM) that include transition and rare earth metals where there is a prominent electron localization as in the case of d and f orbitals due to the nature of their spatial confinement.

Dynamical Mean Field Theory (DMFT) is …

Investigating The Mitochondrial Protein Mitoneet In C. Elegans Models Of Aging And Alzheimer's Disease, Jacob Ryan Boos

Graduate Theses, Dissertations, and Problem Reports (ETD)

Oxidative stress is an imbalance between reactive oxygen species production and elimination, favoring the former. Reactive oxygen species serve as important signaling molecules for physiological homeostasis. However, when produced in excess, these once important signaling molecules become detrimental, disrupting cellular functions, and ultimately leading to cell death. In aging, reactive oxygen species production is increased, accompanied with reductions in oxidative stress resistance, increasing the risk for developing age-related diseases including cardiovascular disease, cancer, stroke, and neurodegenerative diseases. The outer mitochondrial membrane iron-sulfur cluster containing protein mitoNEET (CISD1; gene CISD1) has shown to be a mediator of mitochondrial function and …

Vaping During Pregnancy: Effects On Vascular And Behavioral Outcomes In Offspring, Eiman A. Aboaziza

Graduate Theses, Dissertations, and Problem Reports (ETD)

Electronic cigarette (e-cig) use is increasing due to aggressive marketing, tempting flavors, and seemingly higher acceptability in the community (lesser perceived social stigma) despite unproven claims of safety. In an alarming trend, pregnant women smokers have turned to novel “modified risk” products, such as e-cigs, in response to heavy marketing of e-cigs as safer alternatives to cigarettes and a tool to help quit smoking. This is despite proven detrimental effects of nicotine on a growing fetus, and scarcity of information regarding toxicity of e-liquid (with and without nicotine) on child development. Moreover, rampant e-cig use among youth (nearly 4 million …