Digital Commons Network^™

Determining Haplotype Specific X Chromosome Inactivation State And Related Epigenetic Features In Female X-Linked Genes, Ariah Dawn Mackie

Cal Poly Humboldt theses and projects

Females with heterozygous X-linked mutations are prone to pseudo-haploinsufficiency because random X chromosome inactivation (XCI) silences one of their two X chromosomes. A prior study explored the theory that reactivating the silenced healthy allele could be a treatment for pseudo-haploinsufficient females. The next step was to evaluate this approach in a clinically relevant stem cell model of the rare neurological disease CDKL5 Deficiency Disorder (CDD). It was necessary to validate X-inactivation state with respect to CDKL5 allele expression in one of these models. We explored CDKL5 allele expression in two populations of CDD female patient-derived induced pluripotent stem cells (iPSCs) …

Escherichia Coli And Salmonella Sp. In Domestic Cattle And Wild Roosevelt Elk: Fecal Pathogens At The Wildlife-Domestic Interface, Emily A. Buck

Cal Poly Humboldt theses and projects

Direct or indirect contact between domestic populations of animals and wildlife carries an inherent risk for transmission of pathogens that cause infectious disease. In Humboldt and Del Norte counties of northern California, ongoing conflict between ranchers and Roosevelt elk groups results from elk use of ranching pastures and pastures on private land. Fecal samples from elk in association with cattle, cattle, and from elk not in known association with cattle were assessed for the presence of bacteria Salmonella enterica and pathogenic Escherichia coli to assess whether association with cattle increases risk of infection for elk. Group identity (one of the …

Hormonal Medications And Partner Odor Preferences, Jeffrey Lee Frederick

Cal Poly Humboldt theses and projects

The ability to recognize kin through the olfactory sense has important survival and evolutionary implications when choosing mates. Failing to recognize kin when making a choice of whom to mate with can lead to an increase in detrimental genetic outcomes in offspring. Previous studies have indicated that normally ovulating heterosexual women and men prefer the body odor of those with dissimilar immune systems than those with similar immune systems. The use of hormonal contraceptives has shown a preference for similar immune system odors. The current study examines whether the use of hormonal medications predicts preference for body odor. Importantly, this …

Racial Disparities In Treatments And Mortality Among A Large Population-Based Cohort Of Older Men And Women With Colorectal Cancer, Xianglin L Du, Lulu Song

Faculty, Staff and Student Publications

BACKGROUND: There were racial disparities in treatment and mortality among patients with colorectal cancer, but few studies incorporated information on hypertension and diabetes and their treatment status.

PATIENTS AND METHODS: The study identified 101,250 patients from Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database in the United States who were diagnosed with colorectal cancer at age ≥65 years between 2007 and 2015 with follow-up to December 2016.

RESULTS: There were substantial racial and ethnic disparities in the prevalence of hypertension and diabetes in patients with colorectal cancer, in receiving chemotherapy and radiation therapy, and in receiving antihypertensive and antidiabetic treatment. …

Comorbidities, Health-Related Quality Of Life, Health-Care Utilization In Older Persons With Hemophilia-Hematology Utilization Group Study Part Vii (Hugs Vii), Randall Curtis, Marilyn Manco-Johnson, Barbara A Konkle, Roshni Kulkarni, Joanne Wu, Judith R Baker, Megan Ullman, Duc Quang Tran, Michael B Nichol

Faculty, Staff and Student Publications

PURPOSE: We compare the impact of hemophilia on comorbidities, joint problems, health-related quality of life (HRQoL) and health-care utilization between two age groups: 40-49 years and ≥50 years.

PATIENTS AND METHODS: The HUGS VII study recruited persons with hemophilia A or B age ≥40 years. Participants completed surveys to collect data on sociodemographic and clinical characteristics, hemophilia treatment regimen, pain, joint problems, comorbidities, HRQoL, depression and anxiety, at baseline and 6-months later. Clinical chart reviews documented hemophilic severity and treatment.

RESULTS: The sample includes 69 males, 65.2% aged ≥50 years, 75.4% with hemophilia A. Individuals ≥50 years were more likely …

Blood Metabolites Predicting Mild Cognitive Impairment In The Study Of Latinos-Investigation Of Neurocognitive Aging (Hchs/So), Shan He, Einat Granot-Hershkovitz, Ying Zhang, Jan Bressler, Wassim Tarraf, Bing Yu, Tianyi Huang, Donglin Zeng, Sylvia Wassertheil-Smoller, Melissa Lamar, Martha Daviglus, Maria J Marquine, Jianwen Cai, Thomas Mosley, Robert Kaplan, Eric Boerwinkle, Myriam Fornage, Charles Decarli, Bruce Kristal, Hector M Gonzalez, Tamar Sofer

Faculty, Staff and Student Publications

INTRODUCTION: Blood metabolomics-based biomarkers may be useful to predict measures of neurocognitive aging.

METHODS: We tested the association between 707 blood metabolites measured in 1451 participants from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), with mild cognitive impairment (MCI) and global cognitive change assessed 7 years later. We further used Lasso penalized regression to construct a metabolomics risk score (MRS) that predicts MCI, potentially identifying a different set of metabolites than those discovered in individual-metabolite analysis.

RESULTS: We identified 20 metabolites predicting prevalent MCI and/or global cognitive change. Six of them were novel and 14 were previously reported as …

Incidence Rate Of Psychiatric Disorders In 2020: The Pivotal Role Played By Sars-Cov-2 Infection, Antonio L Teixeira, Regina M Hansen, Joseph S Wozny, Caroline M Schaefer, Rodrigo Machado-Vieira, Lokesh Shahani, Scott D Lane, Jair C Soares, Trudy M Krause

Faculty, Staff and Student Publications

IMPORTANCE: The Coronavirus Disease (COVID-19) pandemic has significantly impacted mental health outcomes. While the frequency of anxiety and depressive symptoms has increased in the whole population, the relationship between COVID-19 and new psychiatric diagnoses remains unclear.

OBJECTIVE: to compare the population incidence rate of emergence of de novo psychiatric disorders in 2020 compared to the previous years, and to compare the incidence rate of new psychiatric disorder diagnoses between people with vs without COVID-19.

DESIGN, SETTING, AND PARTICIPANTS: This study utilized administrative claims data from the Clinformatics® Data Mart database, licensed from Optum®. The study is a cross-sectional analysis that …

Full Issue, Socio-Legal Review

Socio-Legal Review

No abstract provided.

Knowledge, Attitude And Practice Related To Covid-19 Among People- A Descriptive Survey, Pramilaa R

Manipal Journal of Nursing and Health Sciences

Introduction: Corona virus can be deemed as one of the rapidly spreading viral infections. More than 200 countries in less than four months were infected. Findings of a study proved that insight of people in the community is remarkable to render care during pandemics. Characteristics that influence the people to adhere with sound healthy practices and desirable behaviors can be acquired by examining the level of awareness related to COVID-19 among people. Objectives: The objectives of the study were to assess knowledge, attitude and practice related to COVID-19 among people; correlate the knowledge, attitude and practice scores related to COVID-19 …

Assessment Of Maternal Factors Associated With Low Birth Weight At A Tertiary Care Hospital Of South India - An Exploratory Study., Shilpa Varghese, Priya Reshma Aranha

Manipal Journal of Nursing and Health Sciences

Background : Low birth weight is a major public health problem in many of the developing countries. Though the causes are multiple, maternal factors of low birth weight are significant. A large number of infant deaths can be prevented if these factors are identified early and prompt management of low birth weight babies could save life.

Aim :To identify the maternal factors associated with low birth weight in new born among postnatal mothers

Methods : An exploratory research design was adopted to assess the maternal factors associated with low birth weight in new born. Non probability convenience sampling technique was …

A Review On Drug Regulation Policy In The Netherlands And India: The History Of Current Policy Development, And Policy Analysis, Tapashi Adhikary, Pratik Kumar Bal, Kumar Sumit

Manipal Journal of Nursing and Health Sciences

Background

Drug use and illicit trafficking of drugs have been a common problem in both the Netherlands and India since historical times. The Dutch Drug Policy (DDP) model is a combination of both leniency and strict laws whereas the Indian Narcotic Drugs and Psychotropic Substances Act (NDPS Act) went from being a stringent policy in the past to a more flexible lenient policy in recent years. The objective of the current review was to explore the history of the development of the Netherlands and India's drug regulating policies, followed by the analysis of the policies using the Walt & Gilson …

Enhancing Children's Achievement In Basic Science Using Library Electronic Books: A Case Of Simple Repeated Evaluation, Christian Ugwuanyi Phd

Library Philosophy and Practice (e-journal)

The 21^st century classrooms demand a lot from both the teachers and the learners due to the technological developments and demands in teaching and learning. These days, most parents buy their children (smart/android phones, tablets, or laptops without knowing the educational benefits of these gadgets in accessing online learning materials. The 21^st century technology has made the use of e-books very beneficial to the teaming population of learners who have access to the internet, but it is worrisome that there is a dearth of research on such issues in the Nigerian context. Thus, this research examined the effect …

Strategies For Preventing And Mitigating Counterfeit Medication From Entering The U.S. Supply Chain, Denise Blais

Walden Dissertations and Doctoral Studies

Some pharmaceutical brand protection managers lack strategies to mitigate financial losses from counterfeit prescription drugs. A multilayered approach involving guiding principles, supply chain security, investigations, enforcement, advocacy, and awareness can help mitigate potential financial losses and keep patients safe. Guided by the Six Sigma define, measure, analyze, improve, and control (DMAIC) model and the fraud triangle conceptual framework, the purpose of this multiple case study was to explore strategies brand protection managers use to mitigate financial losses from counterfeit prescription drugs. Data collection included three semi-structured interviews using Zoom. Analyzing data entailed transcribing and coding themes within data and relating …

Strategies For Eliminating Workplace Bullying In Long-Term Nursing Care Institutions, Marc A. Bell

Walden Dissertations and Doctoral Studies

Employee-to-employee workplace bullying continues to emerge in long-term nursing care institutions. Workplace bullying can lead to financial loss, high employee turnover, toxicity, and health problems which pose a disruptive challenge for some long-term nursing care leaders. Grounded in Weiss and Cropanzano’s affective events theory, the purpose of this qualitative multiple case study was to explore strategies long-term nursing care leaders use to eliminate employee-to-employee workplace bullying. The participants comprised six leaders from three long-term nursing care institutions in the United States Midwest region who successfully used strategies to eliminate employee-to-employee workplace bullying. The data were collected from semistructured interviews, company …

Dystonia Patients' Use Of Mindfulness To Address Pain, Diana Boyd

Walden Dissertations and Doctoral Studies

This qualitative, phenomenological study was conducted to explore the lived experiences of 10 women who used mindfulness to alleviate their chronic pain associated with cervical dystonia (CD). Individuals who suffer from CD face challenges related to symptom management and the psychological effects from experiencing chronic pain. Since treatments for CD are limited and pharmacological options to treat chronic pain, like opioids, can lead to addictions, individuals with CD may seek non-pharmacological treatment options. Women, 18-60 years of age were interviewed using a semi-structured interview process. Bandura’s self-regulation theory provided a framework for this study. Results from this study found that …

Comparing The Assessment Knowledge And Self-Efficacy Of Science, Technology, Engineering, And Mathematics Faculty With Faculty From Other Disciplines, Karen Elizabeth Braley

Walden Dissertations and Doctoral Studies

Based on reported success and retention rates, there is a need to improve education in 2-year colleges for science, technology, engineering, and mathematics (STEM) majors. Instructors’ assessment knowledge and self-efficacy have not been studied in 2-year or STEM higher education. The problem addressed in this study was that scholars do not know the extent of differences in assessment knowledge and assessment self-efficacy of STEM and non-STEM faculty that could be a contributing factor in student success rates. The purpose of this quantitative study was to determine the extent of differences in STEM and non-STEM instructor assessment knowledge and self-efficacy as …

School Social Workers’ Perceptions Of Compassion Fatigue Syndrome, Gloria I. Collazo Cartagena

Walden Dissertations and Doctoral Studies

School social workers face domestic violence, trauma, social violence, and mental and emotional health problems in their work context. Indeed, compassion fatigue results from professionals’ continuous exposure to these problems. This study explored school social work professionals’ perceptions of compassion fatigue. For this, the following questions were explored:the perception of school social workers working for the Puerto Rico Department of Education about compassion fatigue.

Experiences Of Mechanical Circulatory Support Patients With Primary Implant Education, Dawn Michelle Christensen

Walden Dissertations and Doctoral Studies

Advancement in mechanical circulatory support (MCS) device therapy has led to increased use in heart failure therapy and relies on optimized patient education for successful support. The purpose of this 3-manuscript study, guided by the Husserlian transcendental phenomenological method, was to explore the lived experiences of (a) patients with primary mechanical circulatory support education (PMCSE), (b) patients who undergo unplanned MCS implantation with PMCSE, and (c) patients who undergo planned MCS implantation with PMCSE. Eleven participants were recruited (eight planned, three unplanned) from MCS targeted social media sites and interviewed using a semistructured open-ended question format. Data were analyzed using …

Rural Older Adults’ Wellbeing During The Covid-19 Pandemic, Christina Clevenger

Walden Dissertations and Doctoral Studies

Recent studies reveal adults 65 and over are living longer, healthier lives than ever before. However, this older generation is often vulnerable to exclusion, marginalization, and discrimination, made worse by the events and circumstances of the COVID-19 pandemic. The pandemic brought unprecedented challenges and disproportionate threats to the integrity and wellbeing of older adults, especially those living in rural communities. Nonetheless, little is known about the effects the pandemic had on rural older adults’ wellbeing. This generic qualitative study explored rural older adults’ wellbeing during the pandemic, using the theoretical frameworks of Erikson’s stage theory of psychosocial development and Seligman's …

The Mother-Daughter Attachment-Bond In Adulthood After Childhood Sexual Abuse, Dionne Carla Dauphin

Walden Dissertations and Doctoral Studies

AbstractChildhood sexual abuse (CSA) may have a significant impact on the attachment bond between adult women and their mothers when CSA is disclosed during childhood. When CSA is known by the mother during the period of abuse, and she failed to intervene on behalf of her daughter, there can be long-lasting effects on the mother-daughter attachment bond in the future. There is a gap in the research literature regarding the attachment bond between the mother-daughter dyad in adulthood influenced by CSA known by the mother during the period of abuse. The purpose of this phenomenological study was to understand the …

Role Of Social Media In Adolescent-Parent Relationships Among At-Risk Youths, Jennifer Davis

Walden Dissertations and Doctoral Studies

Social media has been linked to online crimes and cyberbullying among 88% of teens. The purpose of this study was to understand the role of adolescent and parent social media use on adolescents reported at-risk behaviors, as well as the role of social media among at-risk youths and their parents using the attachment theory. An interpretive phenomenological analysis design was used in this study to describe relationships between adolescents and their parents involving social media use and reported at-risk behaviors. Semi-structured interviews were performed with a total of six pairs of individuals resulting in 12 total participants. There were four …

Parenting Style Influence On Future Criminal Behaviors Among Adopted Children In Mozambique, Neidi De Carvalho

Walden Dissertations and Doctoral Studies

Adoption is the process by which an adult legally becomes the parent of a child. This results in the child having the protection of a family and the same rights as a biological child. In Mozambique, there is a lack of research concerning the parenting practices of adoptive parents. This study was conducted to identify the parenting styles of Mozambican adoptive parents to determine if these parenting practices affect the well-being of the adopted child. In this qualitative study, data were collected through virtual interviews with four adoptive parents. Interviews were transcribed manually, and participants confirmed the accuracy of the …

Non Reporting Of Sexual Victimization In Male Prisoners, Christopher Elliott

Walden Dissertations and Doctoral Studies

Sexual assault within prisons continues to occur despite federally mandated safety protocols and reporting procedures. Male inmates must also navigate the challenge of upholding societal gender norms to meet the ideal of hegemonic masculinity as identified in Gender Order Theory. Seven formerly incarcerated males were interviewed for this study. The interviews were designed to explore four relevant topical points which explored the roles that stereotypical/hegemonic masculinity traits play in the reporting of sexual victimization in males who were sexually victimized during incarceration. 2) The role gender roles stress/conflict play in the reporting of sexual victimization in males who were sexually …

Strategies Mental Health Managers Use To Reduce Direct Care Employee Turnover, Theresa Foster

Walden Dissertations and Doctoral Studies

Direct care professionals assist people with intellectual and developmental disabilities with health care services in the consumer's home, community based residential setting, hospitals, and vocational settings. The high turnover rate of direct care professionals working in mental health organizations may jeopardize many services, including administrative, medical, and provisions for the individuals they serve. Retaining direct care professionals is vital due to the expected demand for direct care jobs in the future. Grounded in Herzberg’s two-factor theory, this qualitative multiple case study explored leadership strategies managers from mental health organizations use to retain direct care professionals. Participants were eleven managers from …

Mental Health Providers’ Perspectives: The Link Between Childhood Trauma, Juvenile Delinquency And Long-Term Effects, Vanay Lashon Frederick-Ellis

Walden Dissertations and Doctoral Studies

Juvenile delinquency is an ongoing problem in society and is detrimental as many delinquents have mental and behavioral health issues. Delinquency is costly to society, and it was found that many delinquents have a traumatic past or adverse childhood experiences. They include child abuse and neglect, loss, separation/divorce of parents, witnessing domestic violence, parents who struggle with mental health and/or drug and substance abuse, parents who have their own trauma, death of a loved one, natural disaster, or other tragedies that are linked to an increase in the likelihood of juvenile delinquency. In this study, the relationship between juvenile delinquency …

Sense Of Belonging, Achievement Motivation, And Goal Attainment Through The Lens Of Transgender Activists, Donella Gray

Walden Dissertations and Doctoral Studies

It was not known how transgender activists' lived experiences of a sense of belonging influence their motivations to achieve personal goal attainment. Using the theory of achievement motivation, the purpose of this qualitative phenomenological study was to explore how transgender activists' lived experiences of a sense of belonging influenced their motivations to achieve personal goal attainment. Two topics guided this study: how transgender activists' community participation influenced their sense of belonging and how transgender activists' lived experiences of a sense of belonging influenced their motivation to achieve and personal goal attainment. Thematic analysis was used to identify five themes collected …

Factors That Predict Prescription Opioid Misuse By Type Of Healthcare Insurance Coverage, Keon Green

Walden Dissertations and Doctoral Studies

The opioid epidemic remains one of the leading causes of unintended deaths in the United States and is still one of the focal points of the public health field. Previous research has increased awareness of the opioid crisis and has focused on sociodemographic factors that may cause or predict prescription opioid misuse. The purpose of this study was to investigate sociodemographic factors that may predict prescription opioid misuse while controlling for healthcare insurance. The theoretical foundation for this secondary data analysis project was the socioecological model using the 2019 National Survey on Drug Use and Health. The population was 56,136 …

Holistic Health Among African American Women Remaining In A Marriage After Infidelity, Nena Evette Harris

Walden Dissertations and Doctoral Studies

Infidelity has been noted as a major reason married women experience stress and seek therapy. Infidelity is a social problem that results in adverse outcomes for individuals, families, and society. Health disparities are noted in women who have experienced infidelity. Studies have been conducted on marital status and health, but little has been studied on the holistic health experiences of married African American women who stay in their marriage after a spouse’s infidelity. The purpose of this generic qualitative study was to explore how the experience of marital infidelity affects the holistic health of heterosexual African American women in the …

Parenting Black Daughters: The Parenting Experiences Of Previously Incarcerated African American Males., Sarai D. Hollis

Walden Dissertations and Doctoral Studies

Having a parent incarcerated can have a major effect on children. As it is difficult for the child, it is also difficult for fathers to be away from their children. African American males suffer from various issues revolving around not being present in their children's lives. African American males are one of the largest populations of men incarcerated, and that has a strain on their relationship with their children during and after their release from incarceration. The purpose of this generic qualitative study was to gain a better understanding of the parenting role of African American males while incarcerated to …

Motivation And Statistics Anxiety Among Adult Online Learners: The Mediating Role Of Self-Regulated Learning, Angela Hubbard

Walden Dissertations and Doctoral Studies

Students who experience statistics anxiety have reported struggling with academic performance, an increase in academic dishonesty, and an aversion to careers or majors that are perceived to rely on statistical skills. Research has suggested that statistics anxiety is related to lower levels of motivation; however, it remains unknown if, or to what extent, self-regulated learning skills, including management of time and effort, complex cognitive strategy use, simple cognitive strategy use, contacts with others, and academic thinking may play a role in the relationship between motivation and statistics anxiety. This research study relies on the theoretical foundation of social cognitive theory, …