Digital Commons Network^™

Preventing Kernicterus: Racial Equity For Neonatal Jaundice, Sarah Christensen

Doctor of Nursing Practice Projects

Neonatal jaundice is a common phenomenon among infants worldwide but the condition may progress to severe hyperbilirubinemia and if this progression is left unchecked, kernicterus may result. Kernicterus is the result of bilirubin toxicity that has reached the brain. It may result in irreversible hearing loss, brain damage, and death. Black and African American infants represent twenty five percent of reported kernicterus cases in the United States. This racial health disparity represents a practice gap that this project aims to highlight and address through provider education. Midwives and paraprofessionals at a midwifery organization in the Pacific Northwest were invited to …

Caring For Patients With Obesity: An Intervention To Reduce Bias In Healthcare, Anne S. Balentine

Doctor of Nursing Practice Projects

Background - Implicit and explicit biases held by medical staff towards obese patients reduce obese patients’ outcomes, engagement with medical care, quality and even quantity of life. Studies agree an intervention is needed to reduce obesity bias in medicine, but limited research has been conducted regarding reducing provider bias, and only one study on weight bias has been done in this population. Methods - Participants from Seattle University College of Nursing (SUCON) were recruited for an interrupted time-series study measuring implicit bias and explicit bias with validated tools before and after an educational intervention. The intervention was an asynchronous online …

Effects Of Elevated Temperature, Reduced Hydroperiod, And Invasive Bullfrog Larvae On Pacific Chorus Frog Larvae, Bailey R. Tasker, Karli Honebein, Allie M. Erickson, Julia E. Misslin, Paul Hurst, Sarah Cooney, Skylar Riley, Scott A. Griffith, Betsy A. Bancroft

Biology Faculty Scholarship

Climate change and invasive species threaten many ecosystems, including surface freshwater systems. Increasing temperatures and reduced hydroperiod due to climate change may promote the persistence of invasive species and facilitate new invasions due to potentially higher tolerance to environmental stress in successful invaders. Amphibians demonstrate high levels of plasticity in life history characteristics, particularly those species which inhabit both ephemeral and permanent water bodies. We tested the influence of two projected effects of climate change (increased temperature and reduced hydroperiod) on Pacific chorus frog (Pseudacris regilla) tadpoles alone and in combination with the presence of tadpoles of a …

Embryonic Hypotaurine Levels Contribute To Strain-Dependent Susceptibility In Mouse Models Of Valproate-Induced Neural Tube Defects, John W Steele, Ying Linda Lin, Nellie Chen, Bogdan J Wlodarczyk, Qiuying Chen, Nabeel Attarwala, Madhu Venkatesalu, Robert M Cabrera, Steven S Gross, Richard H Finnell

Faculty, Staff and Students Publications

Valproic acid (VPA, valproate, Depakote) is a commonly used anti-seizure medication (ASM) in the treatment of epilepsy and a variety of other neurological disorders. While VPA and other ASMs are efficacious for management of seizures, they also increase the risk for adverse pregnancy outcomes, including neural tube defects (NTDs). Thus, the utility of these drugs during pregnancy and in women of childbearing potential presents a continuing public health challenge. Elucidating the underlying genetic or metabolic risk factors for VPA-affected pregnancies may lead to development of non-teratogenic ASMs, novel prevention strategies, or more targeted methods for managing epileptic pregnancies. To address …

Effectiveness Of A Web-Based Smoking Cessation Training Program For Health Care Professionals Within An Acute Psychiatric Facility, Allie Carmichael

DNP Projects

Background: Tobacco use is the leading preventable cause of death and disease in the United States, with the prevalence remaining especially high among people with mental illness. Mental health providers often lack training in smoking cessation and feel uncomfortable addressing the issue with this patient population. Studies show that educational training offered to providers can lead to increased knowledge that improves the provider’s confidence and attitude about delivering smoking cessation treatment to patients. Mental health professionals must receive training on smoking cessation treatment modalities so they can effectively provide holistic care needed for recovery for patients with mental illness.

Purpose …

Evaluation Of A Beverage Educational Intervention For Latino Parents Of Infants And Children Ages Nine Months To Five Years, Natalie Chelf

DNP Projects

Background: The Latino population has the highest rate of childhood obesity in the United States. Sugar-sweetened beverage (SSB) consumption has a positive correlation with increased rates of childhood obesity. Current research shows a deficit in culturally sensitive methods to reduce SSB consumption in the pediatric Latino population.

Purpose: The purpose of this project is to empower parents of Latino infants and young children with the knowledge to reduce or eliminate the consumption of SSBs in their child’s diet.

Methods: The project was a one group pre-test post-test quasi-experimental study design occurring in one pediatric outpatient clinic. The Information-Motivation-Behavioral Skills (IMB) …

Evaluation Of A Process Change On Mammography Screening Rates In A Family And Community Medicine Clinic, Christina Rademaker

DNP Projects

Abstract

Background and Significance: Breast cancer is the 2^nd leading cause of cancer death among women worldwide. Mammography is a screening approach used in the detection of breast cancer and proven to help reduce mortality. Only 72.8% of eligible American women have been screened for breast cancer within the past 2 years. One urban family and community medicine clinic (FCM) fell below the national average with a rate of 60.9%; as a result, they implemented an evidence-based strategy to improve mammography rates within the clinic.

Purpose: The purpose of this study was to evaluate the implementation of a telephone …

Effects Of An Educational Module On Perceived Knowledge, Perceived Barriers, And Attitudes Related To Sleep-Promoting Practices Among Bedside Nursing Staff Within A Medical Intensive Care Unit, Arden Gross

DNP Projects

Background: Adult patients in the critical care setting are at risk for experiencing sleep disruption due to critical illness and environmental factors. The effects of disruption to the sleep/wake cycle has been associated with dysregulation of biological processes such as healing and immune system functioning. Current literature includes the use of sleep-promoting protocols that aim to reduce environmental disruptors of sleep in the critical care setting. However, there is a disconnect between the perceived importance of sleep and clinical practice. Additionally, there is a gap in literature exploring the effects of educational-modalities on nursing staff knowledge, perceptions, and attitudes related …

50 Years: Roe V. Wade..., Greer Muldowney, Special Collections, Fleet Library

Artists' Books

16 unnumbered pages : color illustrations Title from cover. "Roe v. Wade, 410 U.S. 113, was a landmark decision of the U.S. Supreme Court, decided on January 22nd, 1973. The Court ruled that the constitution protected the right to have an abortion, securing choice and bodily autonomy for American women. Dobbs v. Jackson Women's Health, No. 19-1392, 597 U.S. nullified the precedent of Roe v. Wade on June 24th, 2022. This decision has left reproductive rights to be decided on a state by state basis, compromising the health and access on healthcare for half of the country after 49.5 years …

The Site Evaluation Of Quercus Alba Metabolites, Zachary Alexander Byrd

Theses and Dissertations--Plant and Soil Sciences

Quercus alba has been the prominent tree species utilized in the spirits industry for decades. Of its many qualities, the ability to impart desirable flavors on spirits combined with its natural abundance makes it the ideal choice for barrels. Creating barrels is a uniform process, but variability still exists in aged spirits even when all other parameters are controlled. In this thesis, I explore how the origin of Quercus alba influences metabolite variability.

Quercus alba is a resilient species that can grow in many climates. This is seen through Quercus alba’s vast growing range, of which barrel quality white oak …

Quantifying Crop Phenology For Food Sustainability Under Climate Change: Integration Of Remote Sensing, Machine Learning, And Ecosystem Modeling, Yanjun Yang

Theses and Dissertations--Plant and Soil Sciences

Climate change is projected to continue and accelerate significantly in the future if global greenhouse gas emissions are not curbed. Previous studies have shown that crop growth and production in agroecosystems are primarily determined by the weather conditions over the growing season. Crop phenology represents one of the most critical indicators in determining crop yield and adjusting the adaptation of crops to climate change. It provides essential information for monitoring and modeling crop growth dynamics and productivity. Therefore, understanding and quantifying the impacts of climate change on crop phenology and then agricultural production is crucial to formulate feasible climatic adaptation …

Regulatory Mechanisms In Arabidopsis Embryogenesis, Sanjay Joshi

Theses and Dissertations--Plant and Soil Sciences

Plants have amazing regeneration properties with single somatic cells, or groups of cells able to give rise to fully formed plants. One means of regeneration is Somatic Embryogenesis (SE), by which an embryonic structure is formed that “converts” into a plantlet. Somatic embryogenesis has been used as a model for zygotic processes that are buried within layers of maternal tissues. Understanding mechanisms of somatic embryo induction and development are important as a more accessible model for seed development. We rely on seed development not only for most of our caloric intake, but also as a delivery system for engineered crops …

The Impact Of Plant Secondary Metabolites On Auxin And Cytokinin Signaling, Timothy E. Shull

Theses and Dissertations--Plant and Soil Sciences

Secondary metabolites are a broad class of specialized compounds that mediate plant-environment interactions and mitigate stress. It is increasingly clear that many phenylalanine-derived secondary metabolites are nearly indispensable for plant survival and that plants adjust their growth according to their secondary metabolic outputs. Consequently, many phenylalanine-derived secondary metabolites have influence over hormone activity. For instance, multiple phenylpropanoid intermediates and catecholamines alter the sensitivity of plants to the central hormone auxin, which in concert with cytokinin directs most aspects of plant growth and development. This dissertation reviews previous research on the influence of phenylpropanoid intermediates and catecholamines on plants, with a …

Understanding The Cellular And Physiological Mechanisms Of Fertilization And Early-Stage Seed Development, Mohammad Foteh Ali

Theses and Dissertations--Plant and Soil Sciences

Flowering plants have evolved a unique double-fertilization process. Two sperm cells fuse with two female gametophytic cells, the egg and central cells within the ovule, giving rise to the embryo and endosperm, respectively. Sperm cells in flowering plants are nonmotile and delivered in close proximity to the egg and central cells by the pollen tube. Flowering plants have established filamentous actin (F-actin) based sperm nuclear migration system for successful fertilization. Prior to fertilization, the female gamete forms a mesh-like structure of F-actin that shows constant inward movement from the plasma membrane periphery to the center of the cell where the …

A Bull In A China Shop: How Cfius Made Tiktok A National Security Problem, Adina Feder

Cardozo International & Comparative Law Review

The note critiques the expansion of the Committee on Foreign Investment in the United States' (CFIUS) mandate under the Foreign Investment Risk Review Modernization Act of 2018 (FIRRMA), particularly its inclusion of "sensitive personal data" as a factor in national security reviews. This expansion has led to overly broad and vague definitions, resulting in unnecessary restrictions on foreign direct investment (FDI) without adequately addressing legitimate national security concerns. The note argues that data privacy issues should be addressed through separate federal privacy legislation rather than CFIUS, which is ill-suited to handle such matters. It calls for clearer definitions and a …

Autumn Is Coming: A Novel Liability Theory That May Kill Pharmaceutical Evergreening, Uri Y. Hacohen

Cardozo Arts & Entertainment Law Journal

Pharmaceutical evergreening-attempts by brand-name manufacturers to leverage patent rights to artificially extend legal protection for drugs-is among the most pressing and unresolved public policy challenges of our time. On July 14, 2021, in Sanofi et al. vs. Unipharm Ltd., the Israeli Supreme Court adopted a novel and internationally unprecedented legal policy to combat the evergreening pandemic. By using its equitable powers, the Israeli court empowered a generic manufacturer, Unipharm, to claim on behalf of the public interest the wrongly obtained monopoly profits that a brand-name manufacturer, Sanofi, obtained by improperly leveraging its improvement patent to impair generic market entry. This …

Genetic Variation Within Nicotine Addiction Pathways In Relation To Smoking Cessation And Smoking Relapse Throughout Adulthood: A Longitudinal Study Of Female Registered Nurses, Stephanie K. Jones

MUSC Theses and Dissertations

Cigarette smoking is a leading cause of premature death and preventable illness; more than 480,000 deaths annually in the U.S. are attributable to smoking. Of the more than 34 million U.S. adult smokers, more than half make a quit attempt each year but more than 90% will relapse within 6 months. Twin studies show that smoking cessation is more than 50% heritable, thus genetics plays a significant role in cessation. However, the understanding of genetic susceptibility to cessation failure is still in its nascent stages. Genetic studies of smoking cessation have typically used short-term follow-up or cross-sectional design, study design …

The Effect Of Robot-Assisted Haptic Guidance On Time Osteotomy Volume, And Bevel Angle In Endodontic Microsurgery, Mithun Suresh

MUSC Theses and Dissertations

The Yomi (Neocis, Miami, FL, USA) is a novel robotic technology that utilizes haptic guidance for implant surgery. No research has been done on robot guided applications for endodontic microsurgery (EMS). The current study was an in vitro study examining how the use of robot guidance would affect the time, osteotomy volume, as well as bevel angle during endodontic microsurgery. The study aimed to compare those variables between a robot guided approach, a second-year endodontic resident freehand, and an experienced endodontist with over fifteen years of experience. Forty-five extracted mandibular molars and premolars were mounted in stone/pumice casts. Endodontic microsurgery …

Invasion Of Plant Communities, Stephen L. Young, Sarah Kimball, Stephen J. Novak

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Due to numerous human activities, organisms have been transported and either accidentally or deliberately introduced all around the globe. Biological invasions are now considered to be one of the main drivers of global change because many invasive plants have severe ecological, economic, and health consequences. Thus, there is an ever-growing need to better understand invasions to determine how specific plant species are able to establish in communities and, in many cases, expand their range. Here, we describe the invasion process and how it contributes to the invasion of plant communities. We present an invasion-factor framework (IFF) model that uses three …

Predicting Spatial-Temporal Patterns Of Diet Quality And Large Herbivore Performance Using Satellite Time Series, Sean P. Kearney, Lauren M. Porensky, David J. Augustine, Justin D. Derner, Feng Gao

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Adaptive management of large herbivores requires an understanding of how spatial-temporal fluctuations in forage biomass and quality influence animal performance. Advances in remote sensing have yielded information about the spatial-temporal dynamics of forage biomass, which in turn have informed rangeland management decisions such as stocking rate and paddock selection for free-ranging cattle. However, less is known about the spatial-temporal patterns of diet quality and their influence on large herbivore performance. This is due to infrequent concurrent ground observations of forage conditions with performance (e.g., mass gain), and previously limited satellite data at fine spatial and temporal scales. We combined multi-temporal …

Predicting Biochemical Acclimation Of Leaf Photosynthesis In Soybean Under In-Field Canopy Warming Using Hyperspectral Reflectance, Etsushi Kumagai, Charles H. Burroughs, Taylor L. Pederson, Christopher M. Montes, Bin Peng, Hyungsuk Kimm, Kaiyu Guan, Elizabeth A. Ainsworth, Carl J. Bernacchi

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Traditional gas exchange measurements are cumbersome, which makes it difficult to capture variation in biochemical parameters, namely the maximum rate of carboxylation measured at a reference temperature (Vcmax25) and the maximum electron transport at a reference temperature (Jmax25), in response to growth temperature over time from days to weeks. Hyperspectral reflectance provides reliable measures of Vcmax25 and Jmax25; however, the capability of this method to capture biochemical acclimations of the two parameters to high growth temperature over time has not been demonstrated. In this study, Vcmax25 and Jmax25 were measured over multiple growth stages during two growing seasons for field-grown …

Blast-Building Leaders For Advancing Science And Technology: A Partnership Between The Virginia Space Grant Consortium And The University Of Virginia, Virginia Polytechnic Institute, And Old Dominion University, Cynthia Tomovic, Mary Sandy, Julie Back, Vukica Jovanovic, Kim Lester, Edward Murphy, Sueanne Mckinney, Mileta Tomovic

STEMPS Faculty Publications

This paper presents the development and delivery of educational summer intensive programs for high school students that are designed to encourage students’ interests in the STEM-related fields and the motivation to pursue a STEM-related degrees in college. BLAST (Building Leaders to Advance Science and Technology) is designed as a summer-intensive, residential, on-campus STEM-learning experience for rising ninth and tenth graders. With the intention of improving the STEM-related workforce pipeline in the Commonwealth of Virginia, Virginia Space Grant Consortium (VSGC) offers multiple BLAST programs across the Commonwealth. BLAST programs are designed as intensive three-day, STEM-related three-hour lecture-lab experiences that are reinforced …

Self-Sexualization In Relation To Sexual Harassment And Body Shame, Dooyoung Choi, Ju-Young M. Kang, Jieun Kim, Ha Kyung Lee

STEMPS Faculty Publications

While many researchers examined several harmful consequences of the imposed or forced sexualization of women, still little is known about voluntary self-sexualization and its potential effects on women who engage in the practice. Although the idea that self-sexualization is self-fulfilling remains contentious, women who self-sexualize are naturally expected to receive sexualized attention, including unwanted attention. This study starts with the question of whether self-sexualizing women, including those who use self-sexualization as a source of power, experience sexual objectification, measured by nonphysical sexual harassment, and its negative consequence, measured by body shame. Furthermore, we investigate how age moderates the relationship. An …

Gender Differences And Roles Of Two Science Self-Efficacy Beliefs In Predicting Post-College Outcomes, Kristy A. Robinson, Tony Perez, Arianna White-Levatich, Lisa Linnenbrink-Garcia

STEMPS Faculty Publications

The end of college is a key transition point when students prepare for the workforce or graduate school, and when competence beliefs that have been shaped throughout college play a particularly important role in decision-making processes. This study examined the roles of two competence beliefs, self-efficacy for scientific tasks and science academic self-efficacy, during the final year of college. A structural equation model was used to examine science research self-efficacy and science academic self-efficacy as predictors of post-graduation science career intentions and life satisfaction; prior achievement was also included as a predictor of competence beliefs and post-graduation outcomes. Findings indicated …

Employing A Network Perspective To Study Hazardous Events In Tourism: Tourism Connections, Island Preferences, And Tourism Market Concentrations In The Hawaiian Islands (2015-2021), Frida Bahja

Electronic Theses and Dissertations, 2020-2023

The purpose of this study was to employ a network perspective to detect fluctuations in tourism (at the level of tourism areas and by inbound tourism markets) that co-occur with hazardous events. Specifically, the study focuses on the Air Travel Tourism (ATT) network of the Hawaiian Islands and its changes with the incidence of nine hazardous events from 2015 to 2021. The three main aspects of the ATT network, which include tourism connections, island preferences, and concentrations of inbound tourism markets were analyzed for a total of eighty-four monthly and seven annual network models. The results suggest that the network …

Ubiquitous Aberration In Cholesterol Metabolism Across Pancreatic Ductal Adenocarcinoma, Venugopal Gunda, Thiago C. Genaro-Mattos, Jyoti B. Kaushal, Ramakanth C. Venkata, Gopalakrishnan Natarajan, Kavita Mallya, Paul M. Grandgenett, Karoly Mirnics, Surinder K. Batra, Zeljka Korade, Satyanarayana Rachagani

Journal Articles: Biochemistry & Molecular Biology

Pancreatic cancer (PC) is characterized by metabolic deregulations that often manifest as deviations in metabolite levels and aberrations in their corresponding metabolic genes across the clinical specimens and preclinical PC models. Cholesterol is one of the critical metabolites supporting PC, synthesized or acquired by PC cells. Nevertheless, the significance of the de novo cholesterol synthesis pathway has been controversial in PC, indicating the need to reassess this pathway in PC. We utilized preclinical models and clinical specimens of PC patients and cell lines and utilized mass spectrometry-based sterol analysis. Further, we also performed in silico analysis to corroborate the significance …

The Gsk3 Kinase And Lztr1 Protein Regulate The Stability Of Ras Family Proteins And The Proliferation Of Pancreatic Cancer Cells, Chitra Palanivel, Neha Chaudhary, Parthasarathy Seshacharyulu, Jesse L. Cox, Ying Yan, Surinder K. Batra, Michel M. Ouellette

Journal Articles: Biochemistry & Molecular Biology

Ras family proteins are membrane-bound GTPases that control proliferation, survival, and motility. Many forms of cancers are driven by the acquisition of somatic mutations in a RAS gene. In pancreatic cancer (PC), more than 90% of tumors carry an activating mutation in KRAS. Mutations in components of the Ras signaling pathway can also be the cause of RASopathies, a group of developmental disorders. In a subset of RASopathies, the causal mutations are in the LZTR1 protein, a substrate adaptor for E3 ubiquitin ligases that promote the degradation of Ras proteins. Here, we show that the function of LZTR1 is regulated …

Tumor Microenvironment Enriches The Stemness Features: The Architectural Event Of Therapy Resistance And Metastasis, Palanisamy Nallasamy, Rama Krishna Nimmakayala, Seema Parte, Abhirup C. Are, Surinder K. Batra, Moorthy P. Ponnusamy

Journal Articles: Biochemistry & Molecular Biology

Cancer divergence has many facets other than being considered a genetic term. It is a tremendous challenge to understand the metastasis and therapy response in cancer biology; however, it postulates the opportunity to explore the possible mechanism in the surrounding tumor environment. Most deadly solid malignancies are distinctly characterized by their tumor microenvironment (TME). TME consists of stromal components such as immune, inflammatory, endothelial, adipocytes, and fibroblast cells. Cancer stem cells (CSCs) or cancer stem-like cells are a small sub-set of the population within cancer cells believed to be a responsible player in the self-renewal, metastasis, and therapy response of …

The Effects Of Road Salt (Nacl), Predation, And Competition On The Growth And Community Interactions Of Spotted Salamanders (Ambystoma Maculatum) And Wood Frogs (Lithobates Sylvaticus), Melissa Ocampo, Catherine A. Chuirazzi, Mizuki Takahashi

Faculty Journal Articles

Road deicing salts are frequently used in northern regions of the world during the winter and early spring months. As a result, a significant portion of road runoff into surrounding aquatic habitats contains road deicing salts. Previous studies found road salt contaminations in vernal pools that pond-breeding amphibians commonly use, including spotted salamanders (Ambystoma maculatum) and wood frogs (Lithobates sylvaticus). Studies have examined the impact of road salt on both amphibian species, but to our knowledge no previous studies have examined how road salt impacts the interspecific competition between both amphibians. We hypothesized that road salt would negatively impact growth …

The Question Is Not “Can Humans Talk?” Or “Can They Suffer?” But “Can They Reason?”, Clive Phillips

Animal Sentience

In their target article, Rowan et al (2022) make a welcome attempt to chart the development of Western progress over the past two hundred years toward formally recognizing that animals feel. They outline the heroic efforts of Compassion in World Farming to gain for animals the status of sentient beings rather than merely human property. A broader view exists, from human prehistory to the present day, in which animals have been (and still are) understood to be sentient by indigenous peoples as well as by some Eastern religions. Growing recognition in the West that animals feel represents a new age …