Digital Commons Network^™

Evolutionary Conservation Of The Dream Subcomplex Muvb, Spencer Snider

Dissertations, Master's Theses and Master's Reports

As the publications of annotated genomes from species representing most domains of life continue to grow exponentially, we are gaining more insight into how proteins, cellular pathways, and protein complexes evolved. We are interested in understanding how each protein in the 8-subunit transcriptional repressor complex called DREAM interacts with each other. DREAM is comprised of 3 main components: an E2F-DP transcription factor heterodimer, a pocket protein, and the highly conserved 5-subunit subcomplex called MuvB. We hypothesize that the mechanism of DREAM’s formation on chromatin dictates how DREAM functions to turn off target gene expression. Unfortunately, many interaction surfaces remain unknown, …

Display Site Selection By Male Ruffed Grouse In The Upper Great Lakes Region, Seth Finkel

Dissertations, Master's Theses and Master's Reports

The Ruffed Grouse (Bonasa umbellus) is widely known for its characteristic territorial drumming display. In this study, I used ruffed grouse drumming survey data from Minnesota and Michigan, in a series of mixed logistic models, to identify drivers of drumming log selection by reproductive male ruffed grouse. I collected drumming stage data utilizing a paired-random sampling structure. I used information theoretic model selection to examine three sets of a priori mixed logistic models: one for the entirety of my Minnesota dataset, one consisting of stages identified in aspen stands in Minnesota, and one for my Michigan dataset. In …

An Antimicrobial Polydopamine Surface Coating To Reduce Biofouling On Telemetry Tags Used In Marine Conservation Practices, Ariana Smies

Dissertations, Master's Theses and Master's Reports

Satellite telemetry tags are used to track the migration patterns of large cetaceans. These tags penetrate the dermis and remain embedded in the underlying blubber tissue. As the dermis of cetaceans is host to a diverse microbiome, and it is impossible to clean the skin before implanting the devices, the potential for infection is increased when the tags penetrate through the skin. H₂O₂ is a potential antimicrobial agent that, in addition to showing broad-spectrum efficacy against gram-negative and gram-positive bacteria, can promote wound healing outcomes by promoting proliferative factors and peptides that protect against oxidative stress. However, …

Beyond Homogenous Decision-Making Models: Role Of Brain Areas Interaction And Heterogeneity, Mohsen Rakhshan

Dartmouth College Ph.D Dissertations

Most existing mechanistic models of decision making consider microcircuits within a homogenous brain area and fail to consider the distributed nature of this cognitive process. More specifically, these models do not take into account: a) how different types of information might influence choice in different stages of the process; and b) how interactions and the heterogeneity between circuits across different brain areas might be essential for the process. In this dissertation, I present a combination of experimental and modeling approaches to study distributed nature of the decision-making by examining both the distributed processing of information as well as the interaction …

The Design Of Cmos Front-End Amplifiers For Electrical Impedance Applications, Yueh-Ching Teng

Dartmouth College Ph.D Dissertations

Electrical Impedance Tomography (EIT) is a medical imaging methodology that does not need any kind of ionizing radiation. It is significantly cheaper and smaller than Computerized Tomography (CT) or Magnetic Resonance Imaging (MRI). These advantages make EIT particularly suitable for emerging applications like the continuous medical imaging and telemonitoring of organ function. Current bench-top EIT systems are bulky and require shielded cables to interface with measurement electrodes. The cable introduces parasitic capacitances which shunt the desired signals and degrade the accuracy of the measurements. A EIT system based on application-specific integrated circuits (ASICs) can reduce the parasitic and stray capacitance …

Phase-Changing Nanodroplets As Nanotheranostic Platform For Combination Cancer Therapy, Catalina-Paula Spatarelu

Dartmouth College Ph.D Dissertations

Cancer is a cluster of diseases, and 1.8 million Americans are newly diagnosed each year. Treatment issues such as drug instability, the occurrence of severe side effects, as well as resistance make the need for solutions to improve conventional methods, like chemotherapy, apparent. Nano-sized drug-delivery platforms, particles loaded with therapeutic molecules that escape the immune system clearance and accumulate at the tumor site, were proposed as one of these solutions. Despite the expansion of the field, several aspects still need to be addressed: inconsistent delivery of the drugs, inability of measuring the effective dose being delivered to the tumor, lack …

In Situ Vaccination Using Plant Viral Particles As A Novel Approach For Cancer Immunotherapy, Chenkai Mao

Dartmouth College Ph.D Dissertations

Non-infectious to mammals, genetically, and physically stable plant virus-based nanoparticles have been increasingly studied as a novel platform for cancer vaccine and adjuvants due to their immunogenic properties. Our prior work showed that, empty cowpea mosaic virus (eCPMV), a plant virus-like particle (VLP) that is composed of a separated capsid, is an excellent in situ vaccine (ISV) for cancer immunotherapy; however, little is known about the mechanisms linked to their activities regarding recognition and antigen presentation.

In the present studies, we report cowpea mosaic virus (CPMV) and RNA-lacking CPMV (empty, eCPMV) are both toll like receptor (TLR) agonists for TLRs …

The Three-Way Interplay Among Early Life Exposures, The Gut Microbiome, And Outcomes In Infancy, Yuka Moroishi

Dartmouth College Ph.D Dissertations

The bidirectional relationship between the gut microbiome and immune system plays an important role in host immune status: the immune system provides the gut microbiome the optimal environment to thrive in, and the gut microbiome helps regulate the immune system. This relationship is especially important in infants, whose immune system is still premature and rely on innate immunity.

We investigated the three-way interplay among early-life exposures, the developing gut microbiome, and outcomes in infancy from the general population in New Hampshire, US. We used prospective cohort data from the New Hampshire Birth Cohort study to 1) determine whether timing of …

Links Between Electrophilic Stress And Antifungal Resistance In Pathogenic Candida Species, Amy R. Biermann

Dartmouth College Ph.D Dissertations

Collectively, Candida species are the most prevalent cause of both superficial and invasive fungal infections worldwide. Invasive Candida infections have a high mortality rate and predominantly affect individuals with underlying diseases, such as diabetes, HIV, or cancer. Unfortunately, many invasive Candida infections are recalcitrant to antifungal treatment, while intrinsically multidrug-resistant pathogens, like Candida auris, are increasing in prevalence. Although the canonical mechanisms of antifungal resistance in Candida species are well established, i.e., overexpression of efflux pumps and overexpression of or mutations in genes encoding drug targets, factors affecting the natural evolution and regulation of resistance mechanisms remain poorly understood. …

Advancing Combined Radiological And Optical Scanning For Breast-Conserving Surgery Margin Guidance, Samuel Stewart Streeter

Dartmouth College Ph.D Dissertations

Breast cancer is one of the most common types of cancer worldwide, and standard-of-care for early-stage disease typically involves a lumpectomy or breast-conserving surgery (BCS). BCS involves the local resection of cancerous tissue, while sparring as much healthy tissue as possible. State-of-the-art methods for intraoperatively evaluating BCS margins are limited. Approximately 20% of BCS cases result in a tissue resection with cancer at or near the resection surface (i.e., a positive margin). A two-fold increase in ipsilateral breast cancer recurrence is associated with the presence of one or more positive margins. Consequently, positive margins often necessitate costly re-excision procedures to …

Soil Organic Carbon Accumulation In Restored Native Prairies Over Time, Samrin Shahnaz

Honors Program Theses

With the recent focus on the causes and effects of climate change, the relationship between agriculture and climate change has become an important concern. Conventional farming maximizes crop production at the expense of ecosystem services like soil carbon storage. As the human population grows, it is vital to develop practices that balance crop production and ecosystem services.

We investigated organic carbon accumulation in restored prairie soil over the course of a decade. Our goal was to determine how organic carbon levels and soil bulk density changed over time, and how that change was influenced by species diversity and soil depth. …

The Development Of A Photographic Atlas Of Plant Adaptations For Pollination, Bethany Van Dusseldorp

Honors Program Theses

Plants have biotic, abiotic, or both biotic and abiotic adaptations for pollination, depending on how they are structured and the attraction between the plant and pollinator. The main focus for this project was biotic adaptations for pollination, and how various plants are specifically structured for the insect, bird, or mammal to pick up the pollen and carry it to the next plant. Documentation, using image/focus stacking and macro photography, was done of the structures of various plants from the University of Northern Iowa (UNI) Botanical Center to support the reason for why plants are structured the way they are. While …

How Exercise Affects The Musculoskeletal System In The Biological Sexes: A Literature Review, Lauren Connolly

Honors Program Theses

Exercise has countless benefits for the human body. Physical activity increases overall health and reduces the risk of developing many chronic diseases. While the entire body is impacted by exercise, the musculoskeletal system is perhaps targeted most directly. Muscle contraction is required to complete any form of exercise, which helps build muscle mass and consequently strengthens bones. The physiology of musculoskeletal growth after exercise is the same for all individuals. However, the magnitude of this growth is not the same for men and women. Men have a profound ability to gain muscle mass that most women are not capable of …

Southern Adventist University Annual Report 2021-2022, Southern Adventist University

Annual Reports

The Annual Report for Southern Adventist University for 2021 to 2022.

Review Of Analytical Techniques For Arsenic Detection And Determination In Drinking Water, Abhijnan Bhat, Tony O'Hara, Furong Tian, Baljit Singh Dr.

Articles

Arsenic occurs in the natural environment in four oxidation states: As(V), As(III), As(0) and As(−III). The behavior of arsenic species changes depending on the biotic or abiotic conditions in water. In groundwater, arsenic is predominantly present as As(III) and As(V), with a minor amount of methyl and dimethyl arsenic compounds being reported. Global intake of As(III) and As(V) via drinking water and food has dramatically increased in recent years. The commonly used term inorganic arsenic includes both As(III) and As(V) species and constitutes the highest toxicological risk associated with arsenic in water compared to the organic arsenic species. Inorganic arsenic …

Biological Properties And Health-Promoting Functions Of Laminarin: A Comprehensive Review Of Preclinical And Clinical Studies, Shanmugapriya Karuppusamy, Gaurav Rajauria, Stephen Fitzpatrick, Henry Lyons, Helena Mcmahon, James Curtin, Brijesh K. Tiwari, Colm O’Donnell

Articles

Marine algal species comprise of a large portion of polysaccharides which have shown multifunctional properties and health benefits for treating and preventing human diseases. Laminarin, or β-glucan, a storage polysaccharide from brown algae, has been reported to have potential pharmacological properties such as antioxidant, anti-tumor, anti-coagulant, anticancer, immunomodulatory, anti-obesity, anti-diabetic, anti-inflammatory, wound healing, and neuroprotective potential. It has been widely investigated as a functional material in biomedical applications as it is biodegradable, biocompatible, and is low toxic substances. The reported preclinical and clinical studies demonstrate the potential of laminarin as natural alternative agents in biomedical and industrial applications such as …

Weird Critters: A Visual Narrative Inspired By Paleontology And Teratology, Kate Murray

Honors Program Theses

Attempts to fuse fantasy and science fiction art work tend to be unidirectional. The artists begin with things that don’t make sense and then force them to make sense to the audience. This can be accomplished in a variety of ways. In some images, dinosaurs are given mechanically sound contraptions; dragons are given tendons, and basilisks are drawn with surprising accuracy. It applies science to the fictional to create an image that is plausible. However, my experience with developmental biology and paleontology suggests that it is equally possible to take it in the other direction and begin with things that …

Transforming Lives For Eternity: 2022-2027 Strategic Plan, Southern Adventist University

Strategic Plans

Southern Adventist University's Strategic Plan for the years 2022-2027.

Chromatography-Mass Spectroscopy Analysis Of Native American Pottery For Maple Syrup Residues, Alexis Wirtz

Honors Program Theses

The research conducted regards whether or not Native Americans understood how to create maple syrup before the influence of Europeans. The analytical technique that was used is gas chromatography-mass spectrometry (GC-MS). This technique assisted in understanding what organic residues resided within the pottery and what those organic residues tell us about Native American history. An analysis of organic residues was performed on the following types of pottery: proof of concept pottery, weathered pottery (an analog of the proof of concept), and Native American pottery. The residues used in analysis were obtained through the usage of different solvent systems - Acetone: …

Measuring The Physicochemical Properties Of Viral Vectors To Enhance Gene Therapy Production, Oluwatoyin Areo

Dissertations, Master's Theses and Master's Reports

Gene therapy is a therapeutic intervention designed to correct single gene disorders. AAV has been identified as a suitable vector for delivering therapeutic genes. However, the use of AAV has been hampered by manufacturing challenges inclusive of low virus recovery, and the presence of AAV without the gene of interest (empty capsids). To solve these problems, we characterized the charge and hydrophobicity of AAV, and surrogate viruses using chemical force microscopy (CFM). CFM uses a modified atomic force microscope (AFM) probe to measure the adhesion force between a virus particle and a functional chemistry.The virus particles to be measured are …

Fine Scale Mapping Of Laurentian Mixed Forest Natural Habitat Communities Using Multispectral Naip And Uav Datasets Combined With Machine Learning Methods, Parth P. Bhatt

Dissertations, Master's Theses and Master's Reports

Natural habitat communities are an important element of any forest ecosystem. Mapping and monitoring Laurentian Mixed Forest natural communities using high spatial resolution imagery is vital for management and conservation purposes. This study developed integrated spatial, spectral and Machine Learning (ML) approaches for mapping complex vegetation communities. The study utilized ultra-high and high spatial resolution National Agriculture Imagery Program (NAIP) and Unmanned Aerial Vehicle (UAV) datasets, and Digital Elevation Model (DEM). Complex natural vegetation community habitats in the Laurentian Mixed Forest of the Upper Midwest. A detailed workflow is presented to effectively process UAV imageries in a dense forest environment …

Viral Sovereignty, Vaccine Diplomacy, And Vaccine Nationalism: The Institutions Of Global Vaccine Access, Sam F. Halabi, Ana Santos Rutschman

Emory International Law Review

The COVID-19 pandemic has triggered a global vaccine race. Distributive questions about which countries will receive scarce doses and under which conditions pervade international law and diplomacy. This Article is the first to describe the phenomena that have driven the development of international vaccine-sharing mechanisms, identify the international organizational forces that explain the phenomena, and explain how international organizations may facilitate international cooperation before, during, and after global crises.

This Article explores the longstanding dissociation between global public health imperatives and nationalist responses to pandemics within the frameworks of “vaccine nationalism,” “viral sovereignty,” and “vaccine diplomacy.” The Article then considers …

The Bi-Partisan Enabling Of Presidential Power: A Review Of David Driesen's The Specter Of Dictatorship: Judicial Enabling Of Presidential Power (2021), Jed Handelsman Shugerman

Faculty Scholarship

In "The Specter of Dictatorship: Judicial Enabling of Presidential Power," David Driesen questions the unitary executive theory and other doctrines of unchecked executive power. He offers primarily a critique of purposivism, a mix of original public meaning and more recent history illuminating those purposes: the Founders’ anti-tyranny purpose and then the rise of European tyranny from Nazi Germany to contemporary Hungary, Turkey, and Poland.
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/="/">This review first focuses on Driesen’s approach to Congress: He identifies the broad congressional delegation of powers to the president as a source of expansive executive power, but he does not entertain that doctrines …

Fast Cbt For Pediatric Ocd: A Multiple-Baseline Controlled Pilot Trial Of Parent Training In Exposure And Response Prevention Delivered, Lara J Farrell, Natalja A Nabinger De Diaz, Sharna Mathieu, Matthew L Mckenzie, Taka Miyamoto, Caroline L Donovan, Allison M Waters, Sonja March, Nicole Bothma, Rianca Kroon, Gabrielle Simcock, Robert S Ware, Robert R Selles, Eric A Storch, Thomas Ollendick

Center for Medical Ethics and Health Policy Staff Publications

Objective: The current study utilized a single case series, non-concurrent multiple baseline design to examine the efficacy of training parents via telehealth videoconferencing in exposure and response prevention (ERP) for home delivery of the treatment for their children and adolescents with obsessive compulsive disorder (OCD).

Method: There were nine participants aged 8 to 14 years who had received a primary diagnosis of OCD. The design involved a series of AB replications, whereby following pre-treatment assessments participants were randomly assigned to either a 2-week (n = 4) or 3-week (n = 5) baseline condition with weekly monitoring of their …

A Privacy Preserving Online Learning Framework For Medical Diagnosis Applications, Trang Pham Ngoc Nguyen

Theses: Doctorates and Masters

Electronic Health records are an important part of a digital healthcare system. Due to their significance, electronic health records have become a major target for hackers, and hospitals/clinics prefer to keep the records at local sites protected by adequate security measures. This introduces challenges in sharing health records. Sharing health records however, is critical in building an accurate online diagnosis framework. Most local sites have small data sets, and machine learning models developed locally based on small data sets, do not have knowledge about other data sets and learning models used at other sites.

The work in this thesis utilizes …

Social Disorganisation Theory And Violent Crime: A Spatial-Econometric Analysis Of Chicago And Sydney, Anthony N. Greening

Theses: Doctorates and Masters

The spatialisation of violent crime is explored in two large case studies, Chicago and Sydney, using spatial econometric methods and macro-sociological variables derived from Social Disorganisation Theory.

Social Disorganisation Theory (SDT) is introduced in terms of its formulation in response to highly specific conditions arising in Chicago, as well as its adoption of methodological and theoretical developments from existing traditions. This specificity belies its breadth of application and enduring presence in criminology. With “Social Disorganisation Theory” hosting a wealth of highly nuanced academic dialogue conducted under its banner, current incarnations of SDT appear as branches on an evolutionary tree. This …

Creation And Evaluation Of The Illinois Cancer Risk Index As A Predictor Of Four Common Cancers, Lei Guo, Margaret E. Wright, Meridith C. Osias, Mahdi Vaezi, M. Courtney Hughes

Faculty Articles, Papers, and Other Scholarship

Introduction

Nearly half of all cancer deaths in the US are attributed to 4 common cancers: lung, colorectal, breast, and prostate. Illinois residents experience higher rates of cancer death from all 4 cancers compared with the US overall. We developed the Illinois Cancer Risk Index (ICRI), which incorporates many predictors of these cancers into a single summary measure, to identify Illinois counties that would benefit most from public health intervention.

Methods

We identified 90 county-level predictors of 4 common cancers, used multicollinearity testing to reduce this number to 61, and applied factor analysis to extract and analyze 4 factors representing …

Domestic Arts, Dates, Drugs, And Dress Codes: Scripps College's Early Attitudes Towards Gender, Sexuality, And Women's Education, Kathleen Mchale

Scripps Senior Theses

This thesis explores how Scripps College's administration, faculty, and students dealt with expectations of gender roles and sexuality during the first two decades of the college's existence. It looks at the historical development of women's colleges, Scripps' curriculum and aims, architecture, residence life, rules and regulations, and applied these areas to discuss how students and other Scripps community members responded to norms about gender and sexuality.

Identification Of The Role Of Swra In Copper Induced Poly-Gamma-Glutamic Acid Production In Bacillus Subtilis, Maya Addison

Scripps Senior Theses

Each year over 2.8 million Americans are infected by an antibiotic resistant strain of bacteria with over 35, 000 dying as a result (CDC). The lack of development of new antibiotics has renewed interest in the antimicrobial properties of copper. Gram positive bacterium such as Bacillus subtilis produce poly-gamma-glutamic acid (γ-PGA) to sequester excess copper ions. swrA has shown to be essential for proper activation of the pgs operon by phosphorylated DegU via an unknown mechanism. This study seeks to determine the role of swrA in copper induced gamma-PGA production and if swrA and ppsB are involved in copper resistance. …

The Moderation Effect Of Sensory Processing Sensitivity On The Relationship Between Prioritizing Positivity And Well-Being, Lauren Nicole Braswell

Scripps Senior Theses

Although many studies have established a significant positive correlation between prioritizing positivity and well-being, very little research has examined potential moderators of this relationship. The purpose of this proposed study is to investigate whether sensory processing sensitivity (SPS) impacts the relationship between prioritizing positivity and well-being. Using a correlational research design, this online study will ask college students to complete a battery of self-report measures assessing participants’ propensity to prioritize positivity, the corresponding level of SPS, and various facets of well-being. It is hypothesized that the impact of prioritizing positivity on well-being will be stronger for high-sensitive individuals than for …