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Ohio Northern University Catalog, 2022-2024, Ohio Northern University

University Catalogs

No abstract provided.

Micro-Rna And Proteomic Profiles Of Plasma-Derived Exosomes From Irradiated Mice Reveal Molecular Changes Preventing Apoptosis In Neonatal Cerebellum, Simonetta Pazzaglia, Barbara Tanno, Ilaria De Stefano, Paola Giardullo, Simona Leonardi, Caterina Merla, Gabriele Babini, Seda Tuncay Cagatay, Ammar Mayah, Munira Kadhim, Fiona Lyng, Christine Von Toerne, Zohaib N. Khan, Prabal Subedi, Soile Tapio, Anna Saran, Mariateresa Mancuso

Articles

Cell communication via exosomes is capable of influencing cell fate in stress situations such as exposure to ionizing radiation. In vitro and in vivo studies have shown that exosomes might play a role in out-of-target radiation effects by carrying molecular signaling mediators of radiation damage, as well as opposite protective functions resulting in resistance to radiotherapy. However, a global understanding of exosomes and their radiation-induced regulation, especially within the context of an intact mammalian organism, has been lacking. In this in vivo study, we demonstrate that, compared to sham-irradiated (SI) mice, a distinct pattern of proteins and miRNAs is found …

Developmental Characteristics Of Young Adolescents: Research Summary, Kathleen Brinegar, Micki M. Caskey

Curriculum and Instruction Faculty Publications and Presentations

This research summary attempts to present a fluid picture of young adolescent development that converges developmental characteristics with social identity in culturally sustaining ways.

Identification Of Circulating Plasma Ceramides As A Potential Sexually Dimorphic Biomarker Of Pancreatic Cancer-Induced Cachexia., Jeffery M Chakedis, Mary E Dillhoff, Carl R Schmidt, Priyani V Rajasekera, David C Evans, Terence M Williams, Denis C Guttridge, Erin E Talbert

Oncology Articles

BACKGROUND: Cancer patients who exhibit cachexia lose weight and have low treatment tolerance and poor outcomes compared to cancer patients without weight loss. Despite the clear increased risk for patients, diagnosing cachexia still often relies on self-reported weight loss. A reliable biomarker to identify patients with cancer cachexia would be a valuable tool to improve clinical decision making and identification of patients at risk of adverse outcomes.

METHODS: Targeted metabolomics, that included panels of amino acids, tricarboxylic acids, fatty acids, acylcarnitines, and sphingolipids, were conducted on plasma samples from patients with confirmed pancreatic ductal adenocarcinoma (PDAC) with and without cachexia …

Age—Not Sex Or Gender—Makes The Case Of Ellie Anderson Complex, Elizabeth Lanphier, Shannon Fyfe

Scholarly Articles

In ’The Complex Case of Ellie Anderson’, Joona Rasanen and Anna Smajdor raise several ethical questions about the case. One question asks, but does not answer, whether Ellie faced discrimination for being transgender when her mother was not allowed access to Ellie’s sperm following her death. In raising the question, the authors imply anti-trans bias may have influenced this determination. However, this inference is not supported by current ethical and legal guidance for posthumous use of gametes, with which Ellie’s case is consistent. We consider the authors’ responses to their other ethical queries, and how their suggestions for what options …

Sex Differences In The Association Of Sibship Size And Position In Sibship With Lipid Profile During Adolescence: A Cross-Sectional Study, Ali H. Ziyab, Mohammad Almari, Anwar Mohammad, Abdullah Al-Taiar, Wilfried Karmaus

Community & Environmental Health Faculty Publications

Background. Epidemiologic studies have reported associations of sibship size and position of the child in the sibship with multiple health outcomes, including adiposity and diabetes. However, little is known about sibling effects on lipids. Hence, this study sought to evaluate associations of the number of total, older, and younger siblings with lipid profile among adolescents. Methods. In a cross-sectional study among high school students aged 14 to 19 years, lipid levels were measured in capillary blood. Parents reported the number of siblings (total, older, and younger). Geometric means of lipids were calculated, and linear regression was used to estimate the …

2022 - 2023, Gardner-Webb Academic Catalog, Gardner-Webb University

Academic Catalogs (Combined Undergraduate & Graduate)

2022 - 2023, Gardner-Webb University Academic Catalog. William Downs, president.

Binding Of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (Bace1) Inhibitor Aminoquinoline (68k) For Possible Treatment Of Alzheimer's Disease, Juhi Dalal, Shreya Averineni, Pranav Madadi, Emily S. Lavin, Arthur Sikora

Protein Modeling Reports

Alzheimer’s Disease (AD), affecting approximately 24 million people worldwide, is characterized by the formation of amyloid-β plaques within the brain. Alzheimer’s research has been focused on limiting amyloid-β production through developing inhibitors for the enzymes needed within the amyloid cascade. This project focuses on the aminoquinoline class of inhibitors, of which 68K (PDB: 5i3Y) is the most effective because of its strong Kd and IC50 values. The students of the Honors Protein Modeling class at Nova Southeastern University modeled the interaction between Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE-1) and 68K. Using Jmol a model was developed, and 3D …

Ua94/6 Company B 3rd Regiment Pershing Rifles Wku 1960s, Doug Verdier

Student/Alumni Personal Papers

Personal narratives of members of the Pershing Rifles compiled by Doug Verdier.

Translocation Of Timber Rattlesnakes At Two West Virginia State Forests, Elizabeth Morgan Johnson

Theses, Dissertations and Capstones

In wildlife management, translocation is defined as the purposeful movement of an individual(s) from one place to another with a wildlife management goal. Translocation has become a common tool for mitigating negative human-wildlife interactions. We conducted a translocation study on timber rattlesnakes (Crotalus horridus) in response to numerous human-rattlesnake encounters with the goal of developing a translocation protocol that would allow natural resources personnel to mitigate negative encounters between the public and rattlesnakes and reduce impacts to local timber rattlesnake populations. In this study, we scaled translocation distance to site-specific home range characteristics to assess whether translocation outcomes …

Trauma As Inclusion, Raquel Aldana, Patrick M. Koga, Thomas O'Donnell, Alea Skwara, Caroline Perris

Tennessee Law Review

This article brings together a historian and law, public health, psychiatry, psychology, and neuroscience faculty and researchers to document how trauma is understood across disciplines and how it has developed in U.S. immigration law largely to exclude but increasingly to include migrants whose lives have been uprooted or otherwise impacted by borders. Our aim is to document and assess the progress and the gaps in immigration law's embrace and understanding of trauma through metrics that include the science of trauma, compassion, and fairness. This analysis is made urgent by the travesty we are witnessing of borders completely shut to desperate …

Antioxidant Biomarkers And Nutraceutical Therapeutics In Neurodegeneration And Neurotrauma, Lilia A. Koza

Electronic Theses and Dissertations

Mild traumatic brain injury (mTBI), yielding a Glascow Coma Scale of 13-15, is the most commonly occurring severity of TBI. Pathology from mTBI consists of blood brain barrier disruption, neuroinflammation, oxidative stress, excitotoxicity, mitochondrial dysfunction, protein aggregation, axonal degeneration, and resulting neuronal death. These processes deplete the body’s endogenous antioxidant system. We report a retrospective analysis of antioxidant blood biomarkers in patients with a history of mTBI from a local sports medicine clinic, Resilience Code. We found persistent sex-specific antioxidant depletions in mTBI patients associated with worsened symptomology.

Certain populations, such as athletes, are at high risk for repetitive mTBI …

Morphological Variation And Community Science In Orthoptera, Amy Byerly

Electronic Theses and Dissertations

Patterns of morphological divergence across species’ ranges provide insight into local adaptation and speciation. Here, we compare phenotypic divergence among 4,221 crickets from 337 populations of two related species of field cricket, Gryllus firmus and G. pennsylvanicus and their hybrids. We find that these species differ across their geographic range in key morphological traits, such as body size and ovipositor length, and we directly compare phenotype with genotype for a subset of crickets demonstrating nuclear genetic introgression, phenotypic intermediacy of hybrids, and essentially unidirectional mitochondrial introgression. We discuss how these morphological traits relate to life history differences between the species. …

The Genuine Alacrity Of Things, Evelyn Hampton

Electronic Theses and Dissertations

“The Genuine Alacrity of Things” is a short story collection. Themes include personal identity, the Anthropocene, grief, family, and relationships. The story collection is introduced by a critical introduction.

Interrupting Holistic Processing May Improve The Detection Of Deceptive Emotional Facial Expressions, Christopher A. Gunderson

Electronic Theses and Dissertations

Although a growing body of evidence suggests that genuine and deceptive facial expressions differ, previous work is mixed as to whether observers can discern between them. One explanation is that cues to deception on the face are subtle and not readily perceived by observers. I argue that the way people process faces may obscure these cues, making them ‘unseen’ by observers. In the current work, I pit two hypotheses against each other to test whether interrupting holistic processing improves or impairs the ability to identify deceptive emotional expressions. Since people process faces holistically, one region of the face may interfere …

Organellar Zn2+ Homeostasis And The Role Of Trpml Channels In Neuronal Lysosome Physiology And Axonal Transport, Taylor Franklin Minckley

Electronic Theses and Dissertations

Zinc (Zn²⁺) is crucial for proper cellular function, and as such it is important to measure and track Zn²⁺ dynamics in living cells. Fluorescent sensors have been used to estimate Zn²⁺ content of subcellular compartments, but little is known about endolysosomal Zn2+ homeostasis. Similarly, although numerous sensors have been reported, it is unclear whether and how Zn²⁺ can be released from intracellular compartments into the cytosol due to a lack of probes that can detect physiological dynamics of cytosolic Zn²⁺. My dissertation started with comparing and characterizing different Zn²⁺ sensors including the …

Great South Bay, Long Island, New York Summer Water Quality Monitoring Program, Cercom, Molloy University, John Tanacredi Ph.D., Kyle F. Maurelli

CERCOM Reports

The Center for Environmental Research and Coastal Oceans Monitoring (CERCOM) visits 11 locations in the Great South Bay from Memorial Day – Labor Day to monitor dissolved oxygen (DO), pH, salinity, clarity and temperature. Students are trained to assist in CERCOM’s water quality data collection by research assistant Mr. Kyle Maurelli. This monitoring program has been conducted for the past 17 years. These parameters are critical in determining long term water quality conditions in Long Island estuaries

Does Empathic Anger Motivate People To Act On Pro-Defending Cognitions?, Adir Pinchot

Theses and Dissertations

Recent theoretical and empirical work suggests that empathic anger represents a form of anger that motivates bystanders to intervene and defend victims of aggression. Prior research on defending behavior has identified cognitive correlates of defending, but most studies failed to distinguish between different forms of defending and did not evaluate how these cognitions interact with emotions, such as empathic anger, in motivating or inhibiting defending behavior. This study attempted to address these lacunae by analyzing whether empathic anger moderates the associations between cognitions associated with defending (i.e., perspective taking, moral disengagement, and self-efficacy for defending) and different types of defending …

Racial Bias In The Association Of Externalizing Symptoms With Black And White Children: The Development And Application Of An Implicit Association Test, Maura Francis

Theses and Dissertations

The objective of this study was to test the hypothesis that school and mental health professionals more strongly associate externalizing behaviors with Black children compared to White children. To test this hypothesis, we developed an implicit association test to determine if there was a difference in the reaction times in classifying symptoms as externalizing when the symptoms were paired with the word “Black Child” as opposed to paired with the word “White Child”. In a sample of 54 school and mental health professionals, we found clear evidence in support of our hypothesis. The existence of this implicit bias may explain …

Social Attention And Memory In Youth With Asd, Adnp Syndrome, And Foxp1 Syndrome, Megan L. Braconnier-Krupa

Theses and Dissertations

The current study used eye tracking and behavioral measures to examine social attention and recognition memory in two rare genetic disorders commonly associated with autism spectrum disorder (ASD): ADNP syndrome and FOXP1 syndrome. Impairment in social functioning is considered a core deficit in ASD. Although individuals with ADNP syndrome and FOXP1 syndrome typically present with symptoms of ASD, research suggests several dissimilarities in symptom presence and severity between the groups. Thus, there is a need to clarify disorder-specific patterns of social attention and their relationships to observed social skills. A visual paired comparison eye tracking task was used to assess …

The Internal And External Expectancies Scale: Development And Validation., Joanne Raptis

Theses and Dissertations

Healthy lifestyle habits are widely known to improve physical and psychological wellbeing, but many struggle to regularly practice these behaviors. As an overarching solution has yet to emerge, it may prove more fruitful to instead personalize behavior change recommendations and interventions. The present study examined whether individual responsiveness to internal and external expectations can be measured, as it could be a useful behavioral factor to target with tailored treatment recommendations. This construct was first postulated by popular author Gretchen Rubin (2015) but has yet to be studied empirically. For the current project, the Internal and External Expectancies Scale (IEES) was …

Testing The Drosophila Maternal Haploid Gene For Functional Divergence And A Role In Hybrid Incompatibility, Dean M. Castillo, Benjamin Mccormick, Connor M. Kean, Sahana Natesan, Daniel A. Barbash

Nebraska Cooperative Extension: Faculty and Staff Publications

Crosses between Drosophila simulans females and Drosophila melanogaster males produce viable F1 sons and poorly viable F1 daughters. Unlike most hybrid incompatibilities, this hybrid incompatibility violates Haldane’s rule, the observation that incompatibilities preferentially affect the heterogametic sex. Furthermore, it has a different genetic basis than hybrid lethality in the reciprocal cross, with the causal allele in Drosophila melanogaster being a large species-specific block of complex satellite DNA on its X chromosome known as the 359-bp satellite, rather than a protein-coding locus. The causal allele(s) in Drosophila simulans are unknown but likely involve maternally expressed genes or factors since the F1 …

Floral Inventory And Phenology At Flat Iron Lake Preserve, Taylor Smelker

Summer Research

This study was conducted at the Flat Iron Lake preserve located in Greenville, Michigan. Since around 2008. students have been on the preserve to study the blooming season of flowers and how they are affected by climate change. The property consists of habitats such as a prairie, woody forests, a vernal pool, a ravine and two swamps

Bostock: An Inevitable Guarantee Of Heightened Scrutiny For Sexual Orientation And Transgender Classifications, Kaleb Byars

Tennessee Law Review

In June 2020, the Supreme Court decided Bostock v. Clayton County. In Bostock, the Court held that discrimination on the basis of sexual orientation and transgender status per se constitutes discrimination "because of sex" for purposes of Title VIL But Bostock inspires the question of whether its holding and reasoning apply in other contexts, including the Equal Protection Clause context. While the Supreme Court has held intermediate scrutiny applies to sex classifications analyzed under the Equal Protection Clause, the Court has yet to elucidate the level of scrutiny that applies to LGBTQ classifications. Meanwhile, state and federal courts have developed …

Supporting Aesthetic Experience Of Science In Everyday Life, Leslie Atkins Elliott

Curriculum, Instruction, and Foundational Studies Faculty Publications and Presentations

Researchers have argued that a central goal of science education is to transform students' out-of-school experiences, so that students have aesthetic experiences of the world that would not otherwise be available to them. The goal of this paper is to articulate a set of design principles that support this goal. In doing so, I will first position this as a problem of transfer, and describe a perspective on transfer in which an idea or experience is not so much abstracted from its original context, but one in which the learning context incorporates out-of-class contexts, and vice versa. After characterising a …

Full Issue

Interpreter: A Journal of Latter-day Saint Faith and Scholarship

No abstract provided.

An Unexpected Case For An Anthropomorphic God, Daniel C. Peterson

Interpreter: A Journal of Latter-day Saint Faith and Scholarship

Given the knowledge of the corporeal, embodied nature of God that the Prophet Joseph Smith received in his 1820 First Vision, Latter-day Saints have argued from their earliest days that the Bible is most accurately understood as teaching precisely the same thing — that God has a body and that humans are literally created in his physical image. Now, a new book from an unlikely (and quite unintentional) ally makes a strong case for our position. It is a book that will both gratify Latter-day Saints and, at some points, offend them. In any event, readers of Interpreter should be …

Clypeasteroida Sp., Sand Dollar Test, Delaney Deinlein, Sarah Gerega, Amy Hirons

Hirons Field Techniques

Test from Clypeasteroida sp. Collected from Sanibel Island, Florida just before Hurricane Ian (before Sep 28, 2022) by Sarah Gerega.

Grading With A Self-Evaluation Rubric: Acknowledging The Effect Of Moral Luck On A Student’S Learning Process In Higher Education, Leelah Klauber

Philosophy Honors Papers

No abstract provided.

Constructing Kurdistan: Cross-Border Kurdish Relations And Ethnic Identity, Benjamin Meyer

Government and International Relations Honors Papers

This thesis examines the emergence and politicization of ethnic identity in the Kurdish populations of Turkey, Iraq, Iran, and Syria. Through a historical analysis of Kurdish revolts and nationalist movements the late imperial and colonial eras, it demonstrates that ‘Kurdishness’, or Kurdayetî, has been instrumentalized as ethnonationalism primarily in a defensive capacity, in response to external coercive pressures forcing the Kurds to ‘think like a state’ and view themselves in increasingly ethnopolitical terms. By illustrating the extent to which ethnonationalism was imposed upon the Kurdish people and the limited appeal it enjoyed in the first half of the twentieth century, …