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Style Of Meal Service And Feeding Practices Among Mexican American Fathers And Mothers: An Analysis Of Video-Recorded Children’S Evening Mealtime At Home, Carlos Penilla, Jeanne M Tschann, Lauri A Pasch, Elena Flores, Julianna Deardorff, Suzanna M Martinez, Nancy F Butte, Louise C Greenspan Feb 2022

Style Of Meal Service And Feeding Practices Among Mexican American Fathers And Mothers: An Analysis Of Video-Recorded Children’S Evening Mealtime At Home, Carlos Penilla, Jeanne M Tschann, Lauri A Pasch, Elena Flores, Julianna Deardorff, Suzanna M Martinez, Nancy F Butte, Louise C Greenspan

Children’s Nutrition Research Center Staff Publications

The aim of this study was to examine video-recorded observations of evening family mealtime at home among Mexican American children to help elucidate style of meal service, fathers' and mothers' feeding practices and child's eating behavior. Consistent with guidelines for coding behaviors, we analyzed observational data of evening mealtimes of 71 Mexican American children aged eight to 10 years. Regarding style of meal service, in almost all cases (96%), parents plated the child's food, with more available on the table or counter in 40% of the observations. Mothers almost always served the child (94%). Regarding parental feeding practices, parents used …


Effects Of Cumulative Trauma, Discrimination, And Racial Trauma Among African Americans, Brittany Renee Clayton Feb 2022

Effects Of Cumulative Trauma, Discrimination, And Racial Trauma Among African Americans, Brittany Renee Clayton

Theses and Dissertations

In the current study, we examined the impact of cumulative trauma, racial trauma, and everyday discrimination experiences within the African American community on psychological outcomes. One hundred and nineteen participants completed a series of self-report measures that analyzed their experiences of lifetime stressors, racial trauma, frequency of everyday discrimination, current posttraumatic stress disorder, depressive symptoms, and experiential avoidance levels. It was hypothesized that increased exposure to lifetime stressors, racial trauma events or experiences, and everyday discrimination would be associated with increased psychological distress. Correlations were conducted to identify and examine these relationships. This hypothesis was supported for lifetime stressor exposure …


Older Adults' Perceptions Of Government Handling Of Covid-19: Predictors Of Protective Behaviors From Lockdown To Post-Lockdown, Savannah Kiah Hui Siew, Jonathan Louis Chia, Rathi Mahendran, Junhong Yu Feb 2022

Older Adults' Perceptions Of Government Handling Of Covid-19: Predictors Of Protective Behaviors From Lockdown To Post-Lockdown, Savannah Kiah Hui Siew, Jonathan Louis Chia, Rathi Mahendran, Junhong Yu

Research Collection School of Social Sciences

Background: Distrust, and more broadly, public perception of government's handling of a crisis, has been a widely studied topic within health crisis research and suggests that these perceptions are significantly associated with the behavior of its citizens. Purpose: To understand which aspects of the public's perception of government handling of the COVID-19 pandemic predicted engagement of protective behaviors among older adults, who are the most vulnerable to COVID-19.Methods: Participants were recruited from an ongoing biopsychosocial study on aging amongst community-dwelling older adults. There were two rounds of data collection, during the national lockdown and post-lockdown. The average length of follow-up …


Assessing The Psychosocial Dimensions Of Frailty Among Older Adults In Singapore: A Community-Based Cross-Sectional Study, Elliot Yeung Chong, Angela Hui-Shan Lim, Freda Cheng Yee Mah, Lyn Hui Wen Yeo, Shu Tian Ng, Huso Yi Feb 2022

Assessing The Psychosocial Dimensions Of Frailty Among Older Adults In Singapore: A Community-Based Cross-Sectional Study, Elliot Yeung Chong, Angela Hui-Shan Lim, Freda Cheng Yee Mah, Lyn Hui Wen Yeo, Shu Tian Ng, Huso Yi

Research Collection School of Social Sciences

Objective To examine how multiple dimensions of mental and social health, in addition to physical health, were associated with frailty among older adults. Design A door-to-door sampling household community-based survey. Setting Thirty-two public housing blocks within a residential town in Singapore's central region. Participants 497 residents aged 60 years or older from the public housing town. Outcome measures Physical frailty was assessed using the FRAIL Scale, which stands for fatigue, resistance, ambulation, illnesses and loss of weight. Physical health was assessed by multimorbidity, physical activity and functional ability; mental illness was assessed by the General Health Questionnaire (GHQ); and social …


February 2022 News Releases, University Of Montana--Missoula. Office Of University Relations Feb 2022

February 2022 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.


Lianas Significantly Reduce Aboveground And Belowground Carbon Storage: A Virtual Removal Experiment, Sergio Estrada-Villegas, Sara Sofia Pedraza Navaez, Adriana Sanchez, Stefan A. Schnitzer Feb 2022

Lianas Significantly Reduce Aboveground And Belowground Carbon Storage: A Virtual Removal Experiment, Sergio Estrada-Villegas, Sara Sofia Pedraza Navaez, Adriana Sanchez, Stefan A. Schnitzer

Biological Sciences Faculty Research and Publications

Lianas are a quintessential tropical plant growth-form; they are speciose and abundant in tropical forests worldwide. Lianas compete intensely with trees, reducing nearly all aspects of tree performance. However, the negative effects of lianas on trees have never been combined and quantified for multiple tropical forests. Here, we present the first comprehensive standardized quantification of the effect of lianas on trees across tropical forests worldwide. We used data from 50 liana removal experiments and quantified the effect size of lianas on tree growth, biomass accretion, reproduction, mortality, leaf water potential, sap flow velocity, and leaf area index (LAI) across different …


Sex-Specific Aging In Animals: Perspective And Future Directions, Anne M. Bronikowski, Richard P. Meisel, Peggy R. Biga, James R. Walters, Judith E. Mank, Erica Larschan, Gerald S. Wilkinson, Nicole Valenzuela, Ashley Mae Conard, João Pedro De Magalhães, Jingyue (Ellie) Duan, Amy E. Elias, Tony Gamble, Rita M. Graze, Kristin E. Gribble, Jill A. Kreiling, Nicole C. Riddle Feb 2022

Sex-Specific Aging In Animals: Perspective And Future Directions, Anne M. Bronikowski, Richard P. Meisel, Peggy R. Biga, James R. Walters, Judith E. Mank, Erica Larschan, Gerald S. Wilkinson, Nicole Valenzuela, Ashley Mae Conard, João Pedro De Magalhães, Jingyue (Ellie) Duan, Amy E. Elias, Tony Gamble, Rita M. Graze, Kristin E. Gribble, Jill A. Kreiling, Nicole C. Riddle

Biological Sciences Faculty Research and Publications

Sex differences in aging occur in many animal species, and they include sex differences in lifespan, in the onset and progression of age-associated decline, and in physiological and molecular markers of aging. Sex differences in aging vary greatly across the animal kingdom. For example, there are species with longer-lived females, species where males live longer, and species lacking sex differences in lifespan. The underlying causes of sex differences in aging remain mostly unknown. Currently, we do not understand the molecular drivers of sex differences in aging, or whether they are related to the accepted hallmarks or pillars of aging or …


How Female Stem Undergraduate Students Form Their Science Identity, Todd Martin Medovich Feb 2022

How Female Stem Undergraduate Students Form Their Science Identity, Todd Martin Medovich

All Theses And Dissertations

This qualitative case study describes how female science, technology, engineering, and mathematics (STEM) students choose their undergraduate major, the obstacles they faced when making that choice, and how they overcome gender-based obstacles. These descriptions illuminate the manner in which they form their science identity.

There is a gender gap in science, technology, engineering, and mathematics (STEM) disciplines (Viadero, 2009). This has been attributed to both biological and sociocultural causes. The biological basis for this disparity includes evidence of physiological differences between females and males, as well as the microaggressions and sexual harassment stemming from these differences (Bottia et al., 2015). …


Characteristics And Assessing Biological Risks Of Airborne Bacteria In Waste Sorting Plant, Abbas Norouzian Baghani, Somayeh Golbaz, Gholamreza Ebrahimzadeh, Marcelo I. Guzman, Mahdieh Delikhoon, Mehdi Jamshidi Rastani, Abdullah Barkhordari, Ramin Nabizadeh Feb 2022

Characteristics And Assessing Biological Risks Of Airborne Bacteria In Waste Sorting Plant, Abbas Norouzian Baghani, Somayeh Golbaz, Gholamreza Ebrahimzadeh, Marcelo I. Guzman, Mahdieh Delikhoon, Mehdi Jamshidi Rastani, Abdullah Barkhordari, Ramin Nabizadeh

Chemistry Faculty Publications

Examining the concentration and types of airborne bacteria in waste paper and cardboard sorting plants (WPCSP) is an urgent matter to inform policy makers about the health impacts on exposed workers. Herein, we collected 20 samples at 9 points of a WPCSP every 6 winter days, and found that the most abundant airborne bacteria were positively and negatively correlated to relative humidity and temperature, respectively. The most abundant airborne bacteria (in units of CFU m−3) were: Staphylococcus sp. (72.4) > Micrococcus sp. (52.2) > Bacillus sp. (30.3) > Enterococcus sp. (24.0) > Serratia marcescens (20.1) > E. coli (19.1) > Pseudomonas sp. (16.0) > Nocardia …


Subthreshold Vibration Influences Standing Balance But Has Unclear Impact On Somatosensation In Persons With Transtibial Amputations, Zachary S. Meade, Aaron D. Likens, Jenny A. Kent, Kota Z. Takahashi, Shane R. Wurdeman, Adam L. Jacobsen, Manuel E. Hernandez, Nick Stergiou Feb 2022

Subthreshold Vibration Influences Standing Balance But Has Unclear Impact On Somatosensation In Persons With Transtibial Amputations, Zachary S. Meade, Aaron D. Likens, Jenny A. Kent, Kota Z. Takahashi, Shane R. Wurdeman, Adam L. Jacobsen, Manuel E. Hernandez, Nick Stergiou

Physical Therapy Faculty Research

Stochastic resonance has been successfully used to improve human movement when using subthreshold vibration. Recent work has shown promise in improving mobility in individuals with unilateral lower limb amputations. Furthering this work, we present an investigation of two different signal structures in the use of stochastic resonance to improve mobility in individuals with unilateral lower limb amputations. Cutaneous somatosensation and standing balance measures using spatial and temporal analysis were assessed. There were no differences in the somatosensation measures, but differences in the temporal characteristics of the standing measures were seen with the various vibration structures when compared to no vibration, …


Water Quality Concentration Trends And Loads Identify Management Needs In The Lake Wister Watershed, Abbie L. Lasater, Brian Haggard Feb 2022

Water Quality Concentration Trends And Loads Identify Management Needs In The Lake Wister Watershed, Abbie L. Lasater, Brian Haggard

Biological and Agricultural Engineering Faculty Publications and Presentations

Trend analyses of water quality seek to determine whether concentrations of constituents have increased or decreased over time, which can show the effectiveness of management practices or the need for pollutant reduction. The Poteau River watershed (PRW) is a transboundary watershed across Arkansas and Oklahoma and, in Arkansas, has been listed as a priority watershed within the Arkansas Nonpoint Source Pollution Plan since 1998. The Poteau River, Black Fork, and Fourche Maline within the PRW flow into Lake Wister, which is an important reservoir for recreation, fishing, and waterfowl hunting for residents and tourists around eastern Oklahoma. The purpose of …


The Effects Of Negative Life Events On Pessimistic Future Outlook: Mediating Effects Of Anxiety And Behavior, Kia Harris Feb 2022

The Effects Of Negative Life Events On Pessimistic Future Outlook: Mediating Effects Of Anxiety And Behavior, Kia Harris

Honors Capstones

No abstract provided.


Population Structure And Genetic Diversity Analysis In Sugarcane (Saccharum Spp. Hybrids) And Six Related Saccharum Species, Haizheng Xiong, Yilin Chen, San-Ji Gao, Yong-Bao Pan, Ainong Shi Feb 2022

Population Structure And Genetic Diversity Analysis In Sugarcane (Saccharum Spp. Hybrids) And Six Related Saccharum Species, Haizheng Xiong, Yilin Chen, San-Ji Gao, Yong-Bao Pan, Ainong Shi

Horticulture Faculty Publications and Presentations

Sugarcane (Saccharum spp. hybrids) is one of the most important commercial crops for sugar, ethanol, and other byproducts production; therefore, it is of great significance to carry out genetic research. Assessing the genetic population structure and diversity plays a vital role in managing genetic resources and gene mapping. In this study, we assessed the genetic diversity and population structure among 196 Saccharum accessions, including 34 S. officinarum, 69 S. spontaneum, 17 S. robustum, 25 S. barberi, 13 S. sinense, 2 S. edule, and 36 Saccharum spp. hybrids. A total of 624 polymorphic SSR …


A Large-Scale Transcriptome-Wide Association Study (Twas) Of 10 Blood Cell Phenotypes Reveals Complexities Of Twas Fine-Mapping, Amanda L Tapia, Bryce T Rowland, Jonathan D Rosen, Michael Preuss, Kris Young, Misa Graff, Hélène Choquet, David J Couper, Steve Buyske, Stephanie A Bien, Eric Jorgenson, Charles Kooperberg, Ruth J F Loos, Alanna C Morrison, Kari E North, Bing Yu, Alexander P Reiner, Yun Li, Laura M Raffield Feb 2022

A Large-Scale Transcriptome-Wide Association Study (Twas) Of 10 Blood Cell Phenotypes Reveals Complexities Of Twas Fine-Mapping, Amanda L Tapia, Bryce T Rowland, Jonathan D Rosen, Michael Preuss, Kris Young, Misa Graff, Hélène Choquet, David J Couper, Steve Buyske, Stephanie A Bien, Eric Jorgenson, Charles Kooperberg, Ruth J F Loos, Alanna C Morrison, Kari E North, Bing Yu, Alexander P Reiner, Yun Li, Laura M Raffield

Faculty, Staff and Student Publications

Hematological measures are important intermediate clinical phenotypes for many acute and chronic diseases and are highly heritable. Although genome-wide association studies (GWAS) have identified thousands of loci containing trait-associated variants, the causal genes underlying these associations are often uncertain. To better understand the underlying genetic regulatory mechanisms, we performed a transcriptome-wide association study (TWAS) to systematically investigate the association between genetically predicted gene expression and hematological measures in 54,542 Europeans from the Genetic Epidemiology Research on Aging cohort. We found 239 significant gene-trait associations with hematological measures; we replicated 71 associations at p < 0.05 in a TWAS meta-analysis consisting of up to 35,900 Europeans from the Women's Health Initiative, Atherosclerosis Risk in Communities Study, and BioMe Biobank. Additionally, we attempted to refine this list of candidate genes by performing conditional analyses, adjusting for individual variants previously associated with hematological measures, and performed further fine-mapping of TWAS loci. To facilitate interpretation of our findings, we designed an R Shiny application to interactively visualize our TWAS results by integrating them with additional genetic data sources (GWAS, TWAS from multiple reference panels, conditional analyses, known GWAS variants, etc.). Our results and application highlight frequently overlooked TWAS challenges and illustrate the complexity of TWAS fine-mapping.


Genetic Errors Of Immunity Distinguish Pediatric Nonmalignant Lymphoproliferative Disorders, Lisa R Forbes, Olive S Eckstein, Nitya Gulati, Erin C Peckham-Gregory, Nmazuo W Ozuah, Joseph Lubega, Nader K El-Mallawany, Jennifer E Agrusa, M Cecilia Poli, Tiphanie P Vogel, Natalia S Chaimowitz, Nicholas L Rider, Emily M Mace, Jordan S Orange, Jason W Caldwell, Juan C Aldave-Becerra, Stephen Jolles, Francesco Saettini, Hey J Chong, Asbjorg Stray-Pedersen, Helen E Heslop, Kala Y Kamdar, R Helen Rouce, Donna M Muzny, Shalini N Jhangiani, Richard A Gibbs, Zeynep H Coban-Akdemir, James R Lupski, Kenneth L Mcclain, Carl E Allen, Ivan K Chinn Feb 2022

Genetic Errors Of Immunity Distinguish Pediatric Nonmalignant Lymphoproliferative Disorders, Lisa R Forbes, Olive S Eckstein, Nitya Gulati, Erin C Peckham-Gregory, Nmazuo W Ozuah, Joseph Lubega, Nader K El-Mallawany, Jennifer E Agrusa, M Cecilia Poli, Tiphanie P Vogel, Natalia S Chaimowitz, Nicholas L Rider, Emily M Mace, Jordan S Orange, Jason W Caldwell, Juan C Aldave-Becerra, Stephen Jolles, Francesco Saettini, Hey J Chong, Asbjorg Stray-Pedersen, Helen E Heslop, Kala Y Kamdar, R Helen Rouce, Donna M Muzny, Shalini N Jhangiani, Richard A Gibbs, Zeynep H Coban-Akdemir, James R Lupski, Kenneth L Mcclain, Carl E Allen, Ivan K Chinn

Faculty, Staff and Student Publications

BACKGROUND: Pediatric nonmalignant lymphoproliferative disorders (PLPDs) are clinically and genetically heterogeneous. Long-standing immune dysregulation and lymphoproliferation in children may be life-threatening, and a paucity of data exists to guide evaluation and treatment of children with PLPD.

OBJECTIVE: The primary objective of this study was to ascertain the spectrum of genomic immunologic defects in PLPD. Secondary objectives included characterization of clinical outcomes and associations between genetic diagnoses and those outcomes.

METHODS: PLPD was defined by persistent lymphadenopathy, lymph organ involvement, or lymphocytic infiltration for more than 3 months, with or without chronic or significant Epstein-Barr virus (EBV) infection. Fifty-one subjects from …


Parent Perspectives On Preparing Students With Intellectual Disabilities For Inclusive Postsecondary Education, Jefferson Clark Sheen, Ty Aller, Robert L. Morgan, Kayla Currier Kipping Feb 2022

Parent Perspectives On Preparing Students With Intellectual Disabilities For Inclusive Postsecondary Education, Jefferson Clark Sheen, Ty Aller, Robert L. Morgan, Kayla Currier Kipping

Sociology, Social Work and Anthropology Faculty Publications

Using a three-round Delphi survey, researchers explored parent perspectives regarding the personal competencies students with intellectual disabilities (ID) needed to be better prepared for participation in an Inclusive Postsecondary Education program (IPSE). An expert panel comprised of parents of students with ID in IPSE programs participated. Three Delphi rounds consisted of open-ended questions and cycles of subsequent rating scales on identified perspectives to establish a quantitative basis for consensus. The parent panel reached consensus on a list of 30 personal competencies that support student preparation for IPSE. A description of the methodology, results, and implications for practice are discussed.


Psyx 587.01: School Psychology Methods, Anisa N. Goforth Feb 2022

Psyx 587.01: School Psychology Methods, Anisa N. Goforth

University of Montana Course Syllabi, 2021-2025

No abstract provided.


Education, Aspiration, And Everyday Diplomacy:An Ethnographic Study Of Female Malaysian Muslim Students In Theuk, Ireena Nasiha Ibnu Feb 2022

Education, Aspiration, And Everyday Diplomacy:An Ethnographic Study Of Female Malaysian Muslim Students In Theuk, Ireena Nasiha Ibnu

Journal of Comparative & International Higher Education

This paper seeks to explore the aspects related to education and aspiration through the on-going experiences of Female Malay Muslim students in UK higher institutions. Building on an ethnographic approach, an in-depth interview with 30 female Malay students, I focus on the various aspects of the students’ lives as scholarship holders, addressing in particular how they handle diplomatic practices in their everyday lives as Malaysian mini ambassadors overseas. The notions of aspiration, well-balanced citizenship and ‘everyday diplomacy’ are deployed in this research to understand the everyday experiences of these students. Hence, it is argued that the privileges in education policy …


Multicenter Retrospective Review Of Ketamine Use In The Icu., Christine M Groth, Christopher A Droege, Kathryn A Connor, Kimberly Kaukeinen, Nicole M Acquisto, Sai Ho J Chui, Michaelia D Cucci, Deepali Dixit, Alexander H Flannery, Kyle A Gustafson, Nina E Glass, Helen Horng, Mojdeh S Heavner, Justin Kinney, Rachel M Kruer, William J Peppard, Preeyaporn Sarangarm, Andrea Sikora, Velliyur Viswesh, Brian L Erstad, Parkview Health Feb 2022

Multicenter Retrospective Review Of Ketamine Use In The Icu., Christine M Groth, Christopher A Droege, Kathryn A Connor, Kimberly Kaukeinen, Nicole M Acquisto, Sai Ho J Chui, Michaelia D Cucci, Deepali Dixit, Alexander H Flannery, Kyle A Gustafson, Nina E Glass, Helen Horng, Mojdeh S Heavner, Justin Kinney, Rachel M Kruer, William J Peppard, Preeyaporn Sarangarm, Andrea Sikora, Velliyur Viswesh, Brian L Erstad, Parkview Health

Parkview Pharmacy Department

This publication is included in our collection because several Parkview pharmacists were involved in the data collection part and acknowledged for the assistance they provided to the overall article. See Comment.

The response of ICU patients to continuously infused ketamine when it is used for analgesia and/or sedation remains poorly established.

OBJECTIVES: To describe continuous infusion (CI) ketamine use in critically ill patients, including indications, dose and duration, adverse effects, patient outcomes, time in goal pain/sedation score range, exposure to analgesics/sedatives, and delirium.

DESIGN SETTING AND PARTICIPANTS: Multicenter, retrospective, observational study from twenty-five diverse institutions in the United States. Patients …


Spatial Epidemiology: An Empirical Framework For Syndemics Research, Shikhar Shrestha, Cici X C Bauer, Brian Hendricks, Thomas J Stopka Feb 2022

Spatial Epidemiology: An Empirical Framework For Syndemics Research, Shikhar Shrestha, Cici X C Bauer, Brian Hendricks, Thomas J Stopka

Faculty, Staff and Student Publications

Syndemics framework describes two or more co-occurring epidemics that synergistically interact with each other and the complex structural social forces that sustain them leading to excess disease burden. The term syndemic was first used to describe the interaction between substance abuse, violence, and AIDS by Merrill Singer. A broader range of syndemic studies has since emerged describing the framework's applicability to other public health scenarios. With syndemic theory garnering significant attention, the focus is shifting towards developing robust empirical analytical approaches. Unfortunately, the complex nature of the disease-disease interactions nested within several social contexts complicates empirical analyses. In answering the …


Craniofacial Fluctuating Asymmetry In Gorillas, Chimpanzees, And Macaques, Ashly N. Romero, D. Rex Mitchell, Siobhán B. Cooke, Claire A. Kirchhoff, Claire E. Terhune Feb 2022

Craniofacial Fluctuating Asymmetry In Gorillas, Chimpanzees, And Macaques, Ashly N. Romero, D. Rex Mitchell, Siobhán B. Cooke, Claire A. Kirchhoff, Claire E. Terhune

Biomedical Sciences Faculty Research and Publications

Objectives

Craniofacial fluctuating asymmetry (FA) refers to the random deviations from symmetry exhibited across the craniofacial complex and can be used as a measure of developmental instability for organisms with bilateral symmetry. This article addresses the lack of data on craniofacial FA in nonhuman primates by analyzing FA magnitude and variation in chimpanzees, gorillas, and macaques. We offer a preliminary investigation into how FA, as a proxy for developmental instability, varies within and among nonhuman primates.

Materials and Methods

We generated 3D surface models of 121 crania from Pan troglodytes troglodytes, Gorilla gorilla gorilla, and Macaca fascicularis fascicularis …


Clinical And Molecular Characterization Of Pole Mutations As Predictive Biomarkers Of Response To Immune Checkpoint Inhibitors In Advanced Cancers, Benjamin Garmezy, Jinesh Gheeya, Heather Y Lin, Yuefan Huang, Taebeom Kim, Xianli Jiang, Kyaw Z Thein, Patrick G Pilié, Fadl Zeineddine, Wanlin Wang, Kenna R Shaw, Jordi Rodon, John Paul Shen, Ying Yuan, Funda Meric-Bernstam, Ken Chen, Timothy A Yap Feb 2022

Clinical And Molecular Characterization Of Pole Mutations As Predictive Biomarkers Of Response To Immune Checkpoint Inhibitors In Advanced Cancers, Benjamin Garmezy, Jinesh Gheeya, Heather Y Lin, Yuefan Huang, Taebeom Kim, Xianli Jiang, Kyaw Z Thein, Patrick G Pilié, Fadl Zeineddine, Wanlin Wang, Kenna R Shaw, Jordi Rodon, John Paul Shen, Ying Yuan, Funda Meric-Bernstam, Ken Chen, Timothy A Yap

Faculty, Staff and Student Publications

Purpose: DNA polymerase epsilon is critical to DNA proofreading and replication. Mutations in POLE have been associated with hypermutated tumors and antitumor response to immune checkpoint inhibitor (ICI) therapy. We present a clinicopathologic analysis of patients with advanced cancers harboring POLE mutations, the pattern of co-occurring mutations, and their response to ICI therapy within the context of mutation pathogenicity.

Methods: We conducted a retrospective analysis of next-generation sequencing data at MD Anderson Cancer Center to identify patient tumors with POLE mutations and their co-occurring mutations. The pathogenicity of each mutation was annotated using InterVar and ClinVar. Differences in therapeutic response …


Ces2 Sustains Hnf4Α Expression To Promote Pancreatic Adenocarcinoma Progression Through An Epoxide Hydrolase-Dependent Regulatory Loop, Yihui Chen, Michela Capello, Mayrim V Rios Perez, Jody V Vykoukal, David Roife, Ya'an Kang, Laura R Prakash, Hiroyuki Katayama, Ehsan Irajizad, Alia Fleury, Sammy Ferri-Borgogno, Dodge L Baluya, Jennifer B Dennison, Kim-Anh Do, Oliver Fiehn, Anirban Maitra, Huamin Wang, Paul J Chiao, Matthew H G Katz, Jason B Fleming, Samir M Hanash, Johannes F Fahrmann Feb 2022

Ces2 Sustains Hnf4Α Expression To Promote Pancreatic Adenocarcinoma Progression Through An Epoxide Hydrolase-Dependent Regulatory Loop, Yihui Chen, Michela Capello, Mayrim V Rios Perez, Jody V Vykoukal, David Roife, Ya'an Kang, Laura R Prakash, Hiroyuki Katayama, Ehsan Irajizad, Alia Fleury, Sammy Ferri-Borgogno, Dodge L Baluya, Jennifer B Dennison, Kim-Anh Do, Oliver Fiehn, Anirban Maitra, Huamin Wang, Paul J Chiao, Matthew H G Katz, Jason B Fleming, Samir M Hanash, Johannes F Fahrmann

Faculty, Staff and Student Publications

Objective: Intra-tumoral expression of the serine hydrolase carboxylesterase 2 (CES2) contributes to the activation of the pro-drug irinotecan in pancreatic ductal adenocarcinoma (PDAC). Given other potential roles of CES2, we assessed its regulation, downstream effects, and contribution to tumor development in PDAC.

Methods: Association between the mRNA expression of CES2 in pancreatic tumors and overall survival was assessed using The Cancer Genome Atlas. Cell viability, clonogenic, and anchorage-independent growth assays as well as an orthotopic mouse model of PDAC were used to evaluate the biological relevance of CES2 in pancreatic cancer. CES2-driven metabolic changes were determined by untargeted and targeted …


Effects Of Placebo Administration On Immune Mechanisms And Relationships With Central Endogenous Opioid Neurotransmission, Alan Prossin, Alisa Koch, Phillip Campbell, Geoffroy Laumet, Christian S Stohler, Robert Dantzer, Jon-Kar Zubieta Feb 2022

Effects Of Placebo Administration On Immune Mechanisms And Relationships With Central Endogenous Opioid Neurotransmission, Alan Prossin, Alisa Koch, Phillip Campbell, Geoffroy Laumet, Christian S Stohler, Robert Dantzer, Jon-Kar Zubieta

Faculty, Staff and Student Publications

Behavioral conditioning and expectation can have profound impact on animal and human physiology. Placebo, administered under positive expectation in clinical trials, can have potent effects on disease pathology, obscuring active medications. Emerging evidence suggests placebo-responsive neurotransmitter systems (e.g., endogenous opioid) regulate immune function by manipulating inflammatory proteins including IL-18, a potent pro-inflammatory, nociceptive cytokine implicated in pathophysiology of various diseases. Validation that neuroimmune interactions involving brain μ-opioid receptor (MOR) activity and plasma IL-18 underlie placebo analgesic expectation could have widespread clinical applications. Unfortunately, current lack of mechanistic clarity obfuscates clinical translation. To elucidate neuroimmune interactions underlying placebo analgesia, we exposed …


Neur 491.01: Neuroanatomy, Katie Marie Holick Feb 2022

Neur 491.01: Neuroanatomy, Katie Marie Holick

University of Montana Course Syllabi, 2021-2025

No abstract provided.


Neur 391.01: Neural Systems Of Behavior & Cognition, Nathan E. Insel Feb 2022

Neur 391.01: Neural Systems Of Behavior & Cognition, Nathan E. Insel

University of Montana Course Syllabi, 2021-2025

No abstract provided.


Ensc 105n.01: Environmental Science, Marilyn J. Marler Feb 2022

Ensc 105n.01: Environmental Science, Marilyn J. Marler

University of Montana Course Syllabi, 2021-2025

No abstract provided.


Ensc 470.01: Agroecology, Caroline Muir Stephens Feb 2022

Ensc 470.01: Agroecology, Caroline Muir Stephens

University of Montana Course Syllabi, 2021-2025

No abstract provided.


M 414.01: Deterministic Models, Emily F. Stone Feb 2022

M 414.01: Deterministic Models, Emily F. Stone

University of Montana Course Syllabi, 2021-2025

No abstract provided.


Psyx 233.50: Fundamentals Of The Psychology Of Aging, Amy E. Violante Feb 2022

Psyx 233.50: Fundamentals Of The Psychology Of Aging, Amy E. Violante

University of Montana Course Syllabi, 2021-2025

No abstract provided.