Digital Commons Network^™

Neural Control Of Stopping And Stabilizing The Arm, Shanie A. L. Jayasinghe, Robert A. Scheidt, Robert L. Sainburg

Biomedical Engineering Faculty Research and Publications

Stopping is a crucial yet under-studied action for planning and producing meaningful and efficient movements. In this review, we discuss classical human psychophysics studies as well as those using engineered systems that aim to develop models of motor control of the upper limb. We present evidence for a hybrid model of motor control, which has an evolutionary advantage due to division of labor between cerebral hemispheres. Stopping is a fundamental aspect of movement that deserves more attention in research than it currently receives. Such research may provide a basis for understanding arm stabilization deficits that can occur following central nervous …

Developing Peri-Operative Rehabilitation In Degenerative Cervical Myelopathy [Ao Spine Recode-Dcm Research Priority Number 6]: An Unexplored Opportunity?, Timothy F. Boerger, Allison S. Hyngstrom, Julio C. Furlan, Sukhvinder Klasi-Ryan, Armin Curt, Brian K. Kwon, Shekar N. Kurpad, Michael G. Fehlings, James S. Harrop, Bizhan Aarabi, Vafa Rahimi-Movaghar, James D. Guest, Jefferson R. Wilson, Benjamin M. Davies, Mark R. N. Kotter, Paul A. Koljonen

Physical Therapy Faculty Research and Publications

Study Design

Narrative review.

Objective

Degenerative cervical myelopathy is one of the most frequent impairments of the spinal cord encountered internationally in adults. Currently, surgical decompression is the recommended treatment for people with DCM (PwCM) presenting with moderate to severe symptoms or neurological deficits. However, despite surgical intervention, not all patients make a complete recovery due to the irreversible tissue damage within the spinal cord. The objective of this review is to describe the state and gaps in the current literature on rehabilitation for PwCM and possible innovative rehabilitation strategies.

Methods

Literature search.

Results

In other neurological disorders such as …

Mental Health In The Uk Biobank: A Roadmap To Self-Report Measures And Neuroimaging Correlates, Rosie K. Dutt, Kayla Hannon, Ty O. Easley, Joseph C. Griffis, Wei Zhang, Janine D. Bijsterbosch

Statistical and Data Sciences: Faculty Publications

The UK Biobank (UKB) is a highly promising dataset for brain biomarker research into population mental health due to its unprecedented sample size and extensive phenotypic, imaging, and biological measurements. In this study, we aimed to provide a shared foundation for UKB neuroimaging research into mental health with a focus on anxiety and depression. We compared UKB self-report measures and revealed important timing effects between scan acquisition and separate online acquisition of some mental health measures. To overcome these timing effects, we introduced and validated the Recent Depressive Symptoms (RDS-4) score which we recommend for state-dependent and longitudinal research in …

The Antibacterial Effect And The Incidence Of Post-Operative Pain After The Application Of Nano-Based Intracanal Medications During Endodontic Retreatment: A Randomized Controlled Clinical Trial, Shehabeldin Mohamed Saber Prof.Dr.

Dentistry

Objective: This clinical trial aimed to evaluate the effect of nano-silver and nano-calcium hydroxide intracanal medicaments (ICM) during retreatment regarding their antibacterial effect and their effect on post-operative pain and flare-ups. Materials and methods: Sixty-nine patients scheduled for endodontic retreatment were included in this randomized clinical trial and randomly allocated to 3 equal groups (n = 23) according to the type of ICM used. The first microbial sampling (S1) representing the original microbiota was obtained after the removal of the old canal filling. After chemo-mechanical debridement, another sample (S2) was obtained representing the microbial state before ICM application. Patients were …

Propagation Of Inflowing Urban Stormwater Pulses Through Reservoir Embayments, Megan Fork, Ryan A. Mcmanamay, James B. Heffernan

Biology Faculty Publications

Flashy hydrology and high solute loads in stormflow are well-studied effects of the built environment on urban streams. The physical and chemical interactions between inflowing stormwater of urban streams and their termination in large impoundments, however, is poorly understood. Determining the spatial distribution of urban stormwater in reservoirs is an important step in understanding the effects of the heat and contaminant loads in these systems, which provide multiple services for adjacent cities. Here, we show that signals of stormwater from a small urban stream can propagate more than 800 m from the stream mouth. Stormflow can also break down the …

Rapid Reductions In Breast Density Following Tamoxifen Therapy As Evaluated By Whole-Breast Ultrasound Tomography, Gretchen L. Gierach, Mark Sak, Shaoqi Fan, Ruth M. Pfeiffer, Maya Palakal, Cody Ramin, Lisa Bey-Knight, Michael S. Simon, David Gorski, Haythem Y. Ali, Peter Littrup, Mark E. Sherman, Nebojsa Duric

Hematology/Oncology Articles

PURPOSE: Women whose mammographic breast density declines within 12-18 months of initiating tamoxifen for chemoprevention or adjuvant treatment show improved therapeutic responses compared with those whose density is unchanged. We tested whether measuring changes in sound speed (a surrogate of breast density) using ultrasound tomography (UST) could enable rapid identification of favorable responses to tamoxifen.

METHODS: We evaluated serial density measures at baseline and at 1 to 3, 4 to 6, and 12+ months among 74 women (aged 30-70 years) following initiation of tamoxifen for clinical indications, including an elevated risk of breast cancer (20%) and diagnoses of in situ …

Preemption & Gender & Racial (In)Equity: Why State Tort Law Is Needed In The Cosmetic Context, Marie C. Boyd

Faculty Publications

Much of the legal scholarship on the preemption of state tort law in the food and drug context and beyond has focused on issues of federalism. While the literature has considered the relationship between state tort law and the regulatory system, it has not generally explored the impact the federal preemption of state tort law may have on women and people of color. Similarly, while the literature has grappled with gender and racial justice issues in the tort system, including in the context of tort reform, it has largely not examined the gender and racial equity issues raised by federal …

Exploring The Effect Of Team Identification On Internationalstudents’ Adjustment To Higher Education In The United States, Kibaek Kim, Merry Moiseichik, Jinwook Han, Sarah Stokowski

Journal of Comparative & International Higher Education

International students have been continuously transitioning to U.S. colleges in pursuit of high- quality education and social mobility opportunities. Multiple studies have dealt with the adjustment of international students in their process of transitioning to a new environment. The purpose of our study is to explore if college sports fan identification can contribute to this population’s adjustment process. This study used lived experiences from 10 international graduate students regarding their college sports fan experiences and how that helped them adjust to American colleges. Results showed that answers from international students derived two themes: social and academic adjustments. Social adjustment was …

Network-Based Pharmacology Study Reveals Protein Targets For Medical Benefits And Harms Of Cannabinoids In Humans, Xingyu Li, Amit Madhukar Kudke, Felix Joseph Nepveux V, Yan Xu

Chemistry Faculty Publications

This network-based pharmacology study intends to uncover the underlying mechanisms of cannabis leading to a therapeutic benefit and the pathogenesis for a wide range of diseases claimed to benefit from or be caused by the use of the cannabis plant. Cannabis contains more than 600 chemical components. Among these components, cannabinoids are well-known to have multifarious pharmacological activities. In this work, twelve cannabinoids were selected as active compounds through text mining and drug-like properties screening and used for initial protein-target prediction. The disease-associated biological functions and pathways were enriched through GO and KEGG databases. Various biological networks [i.e., protein-protein interaction, …

Resistance Is Not Futile: Challenging Aapi Hate, Peter H. Huang

William & Mary Journal of Race, Gender, and Social Justice

This Article analyzes how to challenge AAPI (Asian American Pacific Islander) hate—defined as explicit negative bias in racial beliefs towards AAPIs. In economics, beliefs are subjective probabilities over possible outcomes. Traditional neoclassical economics view beliefs as inputs to making decisions with more accurate beliefs having indirect, instrumental value by improving decision-making. This Article utilizes novel economic theories about belief-based utility, which economically captures the intuitive notion that people can derive pleasure and pain directly from their and other people’s beliefs. Even false beliefs can offer comfort and reassurance to people. This Article also draws on interdisciplinary and multidisciplinary theories …

Curing Corrective Rape: Socio-Legal Perspectives On Sexual Violence Against Black Lesbians In South Africa, Waruguru Gaitho

William & Mary Journal of Race, Gender, and Social Justice

Corrective rape can be defined as a hate crime that entails the rape of any member of a group that does not conform to gender or sexual orientation norms, where the motive of the perpetrator is to “correct” the individual, fundamentally combining gender-based violence and homophobic violence. In the South African context, these biases intersect with systemic racism, producing a disproportionate impact on Black, queer, womxn. While the legal framework has evolved to better address sexual violence crimes, Black lesbians remain prone to falling through the legal cracks, and South African society continues to sanction the homophobia and misogyny that …

An Unfulfilled Promise: Section 1557'S Failure To Effectively Confront Discrimination In Healthcare, Majesta-Doré Legnini

William & Mary Journal of Race, Gender, and Social Justice

When the Patient Protection and Affordable Care Act passed, it offered a broad promise to provide access to quality care on a nondiscriminatory basis. To achieve nondiscrimination, Congress included Section 1557, which integrated the nondiscrimination protections granted under Title VI of the Civil Rights Act of 1964, Title IX of the Education Amendments, Section 504, and the Age Discrimination Act. The language of the statute has proved that the section cannot achieve its broad promise. Covering only intentional discrimination and usually interpreted to divide the standard so that intersectional discrimination cannot be redressed, Section 1557 fails to address discrimination in …

Rice And Beans With A Side Of Queer: Socio-Legal Developments In The Cuban Lgbtq+ Community, Carlos A. Figueroa

William & Mary Journal of Race, Gender, and Social Justice

Over the last century, the LGBTQ+ community has occupied a peculiar space in Cuba that has both resisted and acclimated to the ever-changing sociopolitical dynamics on the Island. This Article examines the Cuban queer community’s socio-legal history in pre- and post-Revolution Cuba along with its tumultuous synthesis into U.S. culture.

Task Effects On Functional Connectivity Measures After Stroke, Kaleb Vinehout, Sheila M. Schindler-Ivens, Jeffrey R. Binder, Brian D. Schmit

Physical Therapy Faculty Research and Publications

Understanding the effect of task compared to rest on detecting stroke-related network abnormalities will inform efforts to optimize detection of such abnormalities. The goal of this work was to determine whether connectivity measures obtained during an overt task are more effective than connectivity obtained during a “resting” state for detecting stroke-related changes in network function of the brain. This study examined working memory, discrete pedaling, continuous pedaling and language tasks. Functional magnetic resonance imaging was used to examine regional and inter-regional brain network function in 14 stroke and 16 control participants. Independent component analysis was used to identify 149 regions …

Evaluation Of Peat Blended With Pine Wood Components For Effects On Substrate Physical Properties, Nitrogen Immobilization, And Growth Of Petunia (Petunia X Hybrida Vilm.-Andr.), Ryan W. Dickson, Kalyn M. Helms, Brian E. Jackson, Leala M. Machesney, Jung Ae Lee

Horticulture Faculty Publications and Presentations

The first objective was to evaluate wood components for differences in nitrogen (N) immobilization and effects on substrate physical properties. The second objective was to evaluate peat substrates amended with pine wood components for effects on plant growth, shoot tissue N, and fertigation practices during production. Substrates consisted of a coarse sphagnum peat blended with four types of processed pine wood at rates of 15%, 30%, 45%, and 60% (by volume). For comparison, peat was also blended with an aged pine bark, perlite, and coconut coir. Nitrogen immobilization was measured for individual components, except perlite. Individual components and blended substrates …

Inspire : Vol 5, Issue 2, Department Of Medicine

INSPIRE – Department of Medicine Archives

Content

• Medicine at National and International Forums
• Webinar on Cervical Cancer
• Nephrology Certificate Course
• In-depth: featuring Associate Professor & Vice Chair – Education Dr Faisal Ismail
• Featured Faculty – Saadia Sattar – Senior Instructor- Research “… human life is very fragile and all we can do is stay positive and do our part … this too shall pass!…”
• Poem section
• What are Academics Around the World Reading This Month?
• Publications

Chronic Absenteeism: Exploring Challenges And Obstacles That Impact Students’ Attendance In Northern Maine Rural Schools, Leland Caron

All Theses And Dissertations

Educational success relies heavily upon consistent school attendance (Rogers & Feller, 2018). In Maine, a student is identified as chronically absent when 10% or more of the days enrolled in school are missed due to excused or unexcused absences (Maine Department of Education, 2019). Chronic absenteeism impacts millions of students across America each year. National data identified that approximately five to seven and a half million school-aged students miss a month or more of school each year (Chang & Davis, 2015). This qualitative interpretative phenological study (IPA) was designed to fill some of the gaps in the literature on chronic …

Longitudinal Clustering Analysis And Prediction Of Parkinson's Disease Progression Using Radiomics And Hybrid Machine Learning, Mohammad R. Salmanpour, Mojtaba Shamsaei, Ghasem Hajianfar, Hamid Soltanian-Zadeh, Arman Rahmim

Research Administration Articles

Background: We employed machine learning approaches to (I) determine distinct progression trajectories in Parkinson's disease (PD) (unsupervised clustering task), and (II) predict progression trajectories (supervised prediction task), from early (years 0 and 1) data, making use of clinical and imaging features.

Methods: We studied PD-subjects derived from longitudinal datasets (years 0, 1, 2 & 4; Parkinson's Progressive Marker Initiative). We extracted and analyzed 981 features, including motor, non-motor, and radiomics features extracted for each region-of-interest (ROIs: left/right caudate and putamen) using our standardized standardized environment for radiomics analysis (SERA) radiomics software. Segmentation of ROIs on dopamine transposer - single photon …

Towards Statistical Best Practices For Gender And Sex Data, Suzanne Thornton, D. Roy, S. Parry, D. Lalonde, W. Martinez, R. Ellis, D. Corliss

Mathematics & Statistics Faculty Works

Suzanne Thornton, Dooti Roy, Stephen Parry, Donna LaLonde, Wendy Martinez, Renee Ellis and David Corliss call for a more inclusive – and informative – approach to collecting data on human gender and sex.

Comparative Analysis Between Saudi Arabia And Norway In Moving Beyond Fossil Fuels Towards A Sustainable Economy: A Special Emphasis On The Renewable Energy Sector, Saad Nasser Alqahtani

Dissertations & Theses

Saudi Arabia is the largest economy in the Middle East and the 18th largest in the world. The country has the world's second-largest proven petroleum reserves and is the largest exporter of petroleum. In 2016, Saudi Arabia had the third highest estimated value of natural resources at $34.4 trillion (US). However, because of the 2014 oil crash, climate change, and the development of renewable energy technology, the government has decided to transition from its complete reliance on oil revenues and to start investing heavily in other non-oil sectors, such as the renewable energy sector. The Saudi government plans to generate …

February 2022 Louisiana Bar Exam, Louisiana Supreme Court Committee On Bar Admissions

Louisiana Bar Exams

No abstract provided.

Sars-Cov-2 Variants Increase Kinetic Stability Of Open Spike Conformations As An Evolutionary Strategy, Ziwei Yang, Yang Han, Shilei Ding, Wei Shi, Tongqing Zhou, Andrés Finzi, Peter D. Kwong, Walther Mothes, Maolin Lu

School of Medical and Biological Sciences Faculty Publications and Presentations

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) harbor mutations in the spike (S) glycoprotein that confer more efficient transmission and dampen the efficacy of COVID-19 vaccines and antibody therapies. S mediates virus entry and is the primary target for antibody responses, with structural studies of soluble S variants revealing an increased propensity toward conformations accessible to the human angiotensin-converting enzyme 2 (hACE2) receptor. However, real-time observations of conformational dynamics that govern the structural equilibriums of the S variants have been lacking. Here, we report single-molecule Förster resonance energy transfer (smFRET) studies of critical mutations observed in …

The Small Rna Universe Of Capitella Teleta, Sweta Khanal, Beatriz Schueng Zancanela, Jacob Oche Peter, Alex Sutton Flynt

Faculty Publications

RNAi is an evolutionarily fluid mechanism with dramatically different activities across animal phyla. One major group where there has been little investigation is annelid worms. Here, the small RNAs of the polychaete developmental model Capitella teleta are profiled across development. As is seen with nearly all animals, nearly 200 microRNAs were found with 58 high-confidence novel species. Greater miRNA diversity was associated with later stages consistent with differentiation of tissues. Outside miRNA, a distinct composition of other small RNA pathways was found. Unlike many invertebrates, an endogenous siRNA pathway was not observed, indicating pathway loss relative to basal planarians. No …

Low-Cost Solar Collectors To Pre-Heat Ventilation Air In Broiler Houses, Yi Liang, Michael Janorschke, Chad E. Hayes

Biological and Agricultural Engineering Faculty Publications and Presentations

The objective of the study was to evaluate the effect of a low-cost solar collector to pre-heat ventilation air in commercial broiler buildings on supplemental heating demand and air quality during the cold season. Six black fabric-based solar collectors of 36 m(2) each were installed on the south-facing rooftop of a broiler house. The solar collectors provided fresh warm air into the house during the ON cycle of minimum ventilation and during the OFF cycle of minimum ventilation when the temperature under the collectors met certain criteria. The daily cumulative duration of solar collectors in operation averaged 125 and 133 …

Direct-To-Consumer Genetic Testing And Its Marketing: Emergent Ethical And Public Policy Implications, Alexander Nill, Gene R. Laczniak

Marketing Faculty Research and Publications

This paper provides a marketing ethics analysis that addresses the practice of selling genetic tests (GT) directly to the consumer (DTC). It details the complexity of this emergent sector by articulating the panoply of evolving ethical/social questions raised by this development. It advances the conversation about DTC genetic testing by reviewing the business and healthcare literature concerning this topic and by laying out the inherent ethical complications for consumers, marketers, and regulators. It also points to several possible public and company policy adjustments. Because this area is relatively new and incredibly dynamic, its current discussion is necessarily an exercise in …

Sex-Related Differences In Aging Rate Are Associated With Sex Chromosome System In Amphibians, Hugo Cayuela, Jean-François Lemaître, Jean-Paul Léna, Victor Ronget, Iñigo Martínez-Solano, Erin Muths, David S. Pilliod, Benedikt R. Schmidt, Gregorio Sánchez-Montes, Jorge Gutiérrez-Rodríguez, Graham Pyke, Kurt Grossenbacher, Omar Lenzi, Jaime Bosch, Karen H. Beard, Lawrence L. Woolbright, Brad A. Lambert, David M. Green, Nathalie Jreidini, Justin M. Garwood, Robert N. Fisher, Kathleen Matthews, David Dudgeon, Anthony Lau, Jeroen Speybroeck, Rebecca Homan, Robert Jehle, Eyup Başkale, Emiliano Mori, Jan W. Arntzen, Pierre Joly, Rochelle M. Stiles, Michael J. Lannoo, John C. Maerz, Winsor H. Lowe, Andrés Valenzuela-Sánchez, Ditte G. Christiansen, Claudio Angelini, Jean-Marc Thirion, Juha Merilä, Guarino R. Colli, Mariana M. Vasconcellos, Taissa C.V. Boas, Ísis Da C. Arantes, Pauline Levionnois, Beth A. Reinke, Cristina Vieira, Gabriel A.B. Marais, Jean-Michel Gaillard, David A.W. Miller

Wildland Resources Faculty Publications

Sex‐related differences in mortality are widespread in the animal kingdom. Although studies have shown that sex determination systems might drive lifespan evolution, sex chromosome influence on aging rates have not been investigated so far, likely due to an apparent lack of demographic data from clades including both XY (with heterogametic males) and ZW (heterogametic females) systems. Taking advantage of a unique collection of capture–recapture datasets in amphibians, a vertebrate group where XY and ZW systems have repeatedly evolved over the past 200 million years, we examined whether sex heterogamy can predict sex differences in aging rates and lifespans. We showed …

Search Full Text Options Here 3 Of 3 Heat-Mitigated Design And Lorentz Force-Based Steering Of An Mri-Driven Microcatheter Toward Minimally Invasive Surgery, Martin Francis Phelan Iii, Mehmet Efe Tiryaki, Jelena Lazovic, Hunter Gilbert, Metin Sitti

Faculty Publications

Catheters integrated with microcoils for electromagnetic steering under the high, uniform magnetic field within magnetic resonance (MR) scanners (3-7 Tesla) have enabled an alternative approach for active catheter operations. Achieving larger ranges of tip motion for Lorentz force-based steering have previously been dependent on using high power coupled with active cooling, bulkier catheter designs, or introducing additional microcoil sets along the catheter. This work proposes an alternative approach using a heat-mitigated design and actuation strategy for a magnetic resonance imaging (MRI)-driven microcatheter. A quad-configuration microcoil (QCM) design is introduced, allowing miniaturization of existing MRI-driven, Lorentz force-based catheters down to 1-mm …

Emergency Bylaws: An Underutilized Tool For Corporate Operation During An Emergency, Grace Myers

William & Mary Business Law Review

Emergency bylaws are an underutilized tool for corporate governance whose importance has been highlighted by COVID-19. Emergency bylaws can be included within corporations’ bylaws and only operate during an “emergency” as defined by state statutes. These provisions usually give boards more agency to act during an emergency through mechanisms such as looser quorum and notice requirements. These provisions will be increasingly important during future pandemics, wars, and global warming. However, few corporations have these bylaws, and the current hodgepodge of state statutes hinders their adoption. The current state of emergency bylaws regulation and implementation raises some questions about shareholder rights …

Herbarium Gets In Touch With Its Roots, Benjamin Borgmann-Winter

UNH Today Archive

No abstract provided.

All-Atom Simulations Uncover Structural And Dynamical Properties Of Sting Proteins In The Membrane System, Rachel Payne, Silvia Crivelli, Masakatsu Watanabe Ph.D.

Chemistry Faculty Publications

Recent studies have shown that the stimulator of interferon gene (STING) protein plays a central role in the immune system by facilitating the production of Type I interferons in cells. The STING signaling pathway is also a prominent activator of cancer-killing T cells that initiates a powerful adaptive immune response. Since biomolecular signaling pathways are complicated and not easily identified through traditional experiments, molecular dynamics (MD) has often been used to study these biological pathways’ structural and dynamical responses. Here, we carried out MD simulations for full-length chicken and human STING (chSTING and hSTING) proteins. Specifically, we investigated ligand-bound closed …