Digital Commons Network^™

Variations In Risks From Smoking Between High-Income, Middle-Income, And Low-Income Countries: An Analysis Of Data From 179 000 Participants From 63 Countries, Thirunavukkarasu Sathish, Koon K. Teo, Philip Britz Mckibbin, Biban Gill, Shofiqul Islam, Guillaume Paré, Sumathy Rangarajan, Mylinh Duong, Fernando Lanas, Romaina Iqbal

Community Health Sciences

Background: Separate studies suggest that the risks from smoking might vary between high-income (HICs), middle-income (MICs), and low-income (LICs) countries, but this has not yet been systematically examined within a single study using standardised approaches. We examined the variations in risks from smoking across different country income groups and some of their potential reasons.
Methods: We analysed data from 134 909 participants from 21 countries followed up for a median of 11·3 years in the Prospective Urban Rural Epidemiology (PURE) cohort study; 9711 participants with myocardial infarction and 11 362 controls from 52 countries in the INTERHEART case-control study; and …

Glycerol-Driven Denitratation: Process Kinetics, Microbial Ecology, And Operational Controls, Matthew Baideme, Chenghua Long, Luke Plante, Jeffrey A. Starke, Michael A. Butkus, Katrik Chandran

Civil and Environmental Engineering Faculty Research and Publications

Denitratation, the selective reduction of nitrate to nitrite, is a novel process and when coupled with anaerobic ammonium oxidation (anammox) could achieve resource-efficient biological nitrogen removal of ammonium- and nitrate-laden waste streams. Using a fundamentally-based, first principles approach, this study optimized a stoichiometrically-limited, glycerol-driven denitratation process and characterized mechanisms supporting nitrite accumulation with results that aligned with expectations. At the optimal influent chemical oxygen demand to nitrate ratio of 3.0 : 1 identified, glycerol supported selective nitrate reduction to nitrite (nitrite accumulation ratio, NAR = 62%) and near-complete nitrate conversion (nitrate reduction ratio, NRR = 96%), indicating its viability in …

Childhood Depression: Identifying Depression In The Pediatric Population, Riley Alvaro

PCOM Capstone Projects

Internalizing disorders, such as major depressive disorder (MDD), are characterized by processes within the self since the primary symptoms tend to involve thoughts and feelings (APA, 2015). MDD is a mood disorder characterized by a persistently sad or irritable mood that affects one’s thinking and behavior and interferes with daily life (APA, 2015). In 2018, 3.2% of the pediatric population ages 3-17 in the United States were diagnosed with depression. (CDC, 2021). Depression and anxiety are comorbid disorders occurring concurrently; 73.8% of children diagnosed with MDD also have anxiety (CDC, 2021).

Internalizing disorders that are quiet and cause internal distress …

College Of Natural Sciences Newsletter, February 2022, College Of Natural Sciences

College of Natural Sciences Newsletters and Reports

Volume 3, Issue 2

Page 1 Dean's Message
Page 2 Awards & Recognition
Page 3-4 Media Coverage of CNS
Page 5- 6 Local Boy Scouts Earn Their Chemistry Merit Badges
Page 7-8 Mount Vernon Teacher Wins 2022 South Dakota Outstanding Physical Science Teacher Award
Page 9 Middle Schoolers Visit SDSU
Page 10 Microbiology Club Tours POET
Page 11 53rd Geography Convention
Page 12 Open PRAIRIE Data

Spatiotemporal Patterns In The Biomass Of Drift Macroalgae In The Indian River Lagoon, Florida, United States, Lauren M. Hall, Lori J. Morris, Robert H. Chamberlain, M. Dennis Hanisak, Robert W. Virnstein, Richard Paperno, Bernhard Riegl, L. Rex Ellis, Ali Simpson, Charles A. Jacoby

Marine & Environmental Sciences Faculty Articles

Drift macroalgae plays key roles in the ecology of many coastal systems, including the Indian River Lagoon. In the lagoon, changes in the biomass of drift macroalgae may have interacted with an unprecedented bloom of phytoplankton in 2011. Patterns in the biomass of drift macroalgae were identified using new and original analyses of data from several sampling programs collected between 1997 and 2019. All available data show a relatively low biomass of drift macroalgae in 2010–2012, and surveys of fixed transects and seining as part of a fisheries independent monitoring program also recorded low biomass in 2016. Low light availability …

A Bayesian Phase I/Ii Biomarker-Based Design For Identifying Subgroup-Specific Optimal Dose For Immunotherapy, Beibei Guo, Yong Zang

Faculty Publications

Immunotherapy is an innovative treatment that enlists the patient's immune system to battle tumors. The optimal dose for treating patients with an immunotherapeutic agent may differ according to their biomarker status. In this article, we propose a biomarker-based phase I/II dose-finding design for identifying subgroup-specific optimal dose for immunotherapy (BSOI) that jointly models the immune response, toxicity, and efficacy outcomes. We propose parsimonious yet flexible models to borrow information across different types of outcomes and subgroups. We quantify the desirability of the dose using a utility function and adopt a two-stage dose-finding algorithm to find the optimal dose for each …

Singing Strategies Are Linked To Perch Use On Foraging Territories In Heart-Nosed Bats, Grace C. Smarsh, Ashley M. Long, Michael Smotherman

Faculty Publications

Acoustic communication allows animals to coordinate and optimize resource utilization in space. Cardioderma cor, the heart-nosed bat, is one of the few species of bats known to sing during nighttime foraging. Previous research found that heart-nosed bats react aggressively to song playback, supporting the territorial defense hypothesis of singing in this species. We further investigated the territorial defense hypothesis from an ecological standpoint, which predicts that singing should be associated with exclusive areas containing a resource, by tracking 14 individuals nightly during the dry seasons in Tanzania. We quantified the singing behavior of individuals at all perches used throughout the …

Strict Lyapunov Functions And Feedback Controls For Sir Models With Quarantine And Vaccination, Hiroshi Ito, Michael Malisoff, Frederic Mazenc

Faculty Publications

We provide a new global strict Lyapunov function construction for a susceptible, infected, and recovered (or SIR) disease dynamics that includes quarantine of infected individuals and mass vaccination. We use the Lyapunov function to design feedback controls to asymptotically stabilize a desired endemic equilibrium, and to prove input-to-state stability for the dynamics with a suitable restriction on the disturbances. Our simulations illustrate the potential of our feedback controls to reduce peak levels of infected individuals.

Predator-Pest Dynamics Of Arthropods Residing In Louisiana Soybean Agroecosystems, Scott T. Lee, Chaoyang Li, Jeffrey A. Davis

Faculty Publications

Over the past two decades, management practices within Louisiana soybean production have shifted. Successful application of an integrated pest management (IPM) strategy requires an understanding of how these changes have affected predator-pest dynamics. Surveys monitoring foliage-foraging arthropod populations in soybean took place across six locations within Louisiana over six years (2012–2014 and 2015–2018). Temporal associations of pest groups, defoliating and piercing-sucking, and predator groups relating to soybean phenology were observed. Additionally, soybean maturity groups (III, IV, and V) were also evaluated to delineate potential differences. Results indicated higher abundances of piercing-sucking pests compared to defoliating pests across both datasets (2012–2014 …

The Body: Undergraduate Lecture Recital, Cara Ramos

Honors Capstones

No abstract provided.

Docking And Molecular Dynamic Of Microalgae Compounds As Potential Inhibitors Of Beta-Lactamase, Roberto Pestana-Nobles, Yani Aranguren-Diaz, Elwi Machado-Sierra, Juvenal Yosa, Nataly J. Galan-Freyle,, Laura X. Sepulveda-Montano, Daniel G. Kuroda, Leonardo C. Pacheco-Londono

Faculty Publications

Bacterial resistance is responsible for a wide variety of health problems, both in children and adults. The persistence of symptoms and infections are mainly treated with beta-lactam antibiotics. The increasing resistance to those antibiotics by bacterial pathogens generated the emergence of extended-spectrum beta-lactamases (ESBLs), an actual public health problem. This is due to rapid mutations of bacteria when exposed to antibiotics. In this case, beta-lactamases are enzymes used by bacteria to hydrolyze the beta-lactam rings present in the antibiotics. Therefore, it was necessary to explore novel molecules as potential beta-lactamases inhibitors to find antibacterial compounds against infection caused by ESBLs. …

Whole-Genome Sequencing And Rna-Seq Reveal Differences In Genetic Mechanism For Flowering Response Between Weedy Rice And Cultivated Rice, Richard S. Garcia, Sapphire Coronejo, Jonathan Concepcion, Prasanta K. Subudhi

Faculty Publications

Flowering is a key agronomic trait that influences adaptation and productivity. Previous studies have indicated the genetic complexity associated with the flowering response in a photoinsensitive weedy rice accession PSRR-1 despite the presence of a photosensitive allele of a key flowering gene Hd1. In this study, we used whole-genome and RNA sequencing data from both cultivated and weedy rice to add further insights. The de novo assembly of unaligned sequences predicted 225 genes, in which 45 were specific to PSRR-1, including two genes associated with flowering. Comparison of the variants in PSRR-1 with the 3K rice genome (RG) dataset identified …

Editorial: Proceedings Of The 21st Biennial Southern Silvicultural Research Conference, John L. Willis, Thomas J. Dean

Faculty Publications

No abstract provided.

Exercise Reduces The Protein Abundance Of Txnip And Its Interacting Partner Redd1 In Skeletal Muscle: Potential Role For A Pka-Mediated Mechanism, Alec B. Chaves, Edwin R. Miranda, Jacob T. Mey, Brian K. Blackburn, Kelly N.Z. Fuller, Blaise Stearns, Andrew Ludlow, David L. Williamson, Joseph A. Houmard, Jacob M. Haus

Division of Basic Science Faculty Publications

Thioredoxin-interacting protein (TXNIP) negatively effects the redox state and growth signaling via its interactions with thioredoxin (TRX) and regulated in development and DNA damage response 1 (REDD1), respectively. TXNIP expression is downregulated by pathways activated during aerobic exercise (AE), via posttranslational modifications (PTMs; serine phosphorylation and ubiquitination). The purpose of this investigation was to determine the effects of acute AE on TXNIP expression, posttranslational modifications, and its interacting partners, REDD1 and TRX. Fifteen healthy adults performed 30 min of aerobic exercise (80% V_ O2max) with muscle biopsies taken before, immediately following, and 3 h following the exercise bout. To explore …

Revisiting Forest Certification In Sri Lanka: The Forest Management And Export Wood-Based Manufacturing Sector Perspectives, Priyan Perera, Rajitha Lakshan Rupasinghe, Devin Weerasekera, Richard Vlosky, Rangika Bandara

Faculty Publications

There are discussions and debates surrounding forest certification in developing coun-tries. In this study, we surveyed 50 forest-based companies in Sri Lanka (43 wood-based manufacturers and 7 plantation companies) to ascertain their participation in forest certification, current and future forest certification trends, as well as their satisfaction with the performance of Forest Stewardship Council (FSC) certification in its economic, environmental, and social aspects, using an importance–performance analysis (IPA). Study results indicate that certified companies typically focus on exports and supplying raw materials for value-added exporters. The customer demand/signaling mechanism appears to be the primary driver of FSC certification in Sri …

Is Catalase An Effective Additive To Alleviate Oxidative Stress During Cryopreservation Of Zebrafish Sperm At The Repository Level?, Huiping Yang, E. Hu, Jennifer L. Matthews, Zoltan M. Varga, Terrence R. Tiersch

Faculty Publications

The goal of this study was to investigate whether supplementation of cryoprotective medium with catalase (CAT), an antioxidation enzyme, is efficient for zebrafish sperm cryopreservation from the viewpoint of high-throughput genetic repository operations. Three cryoprotectants (10%, v/v), dimethylacetamide (DMA), dimethylformamide (DMF), and methanol were used. The objectives were to evaluate the effects of CAT on sperm motility, plasma membrane integrity, and concentration for: 1) fresh sperm at equilibration up to 60 min; 2) post-thaw sperm after cooling at 10, 20, and 40 °C/min), and 3) post-thaw fertilization and embryo survival rates. Catalase addition did not improve sperm motility, regardless of …

Misleading Or Factually Incorrect Statements In The American Journal Of Clinical Nutrition Perspectives Article By Ludwig Et Al, Adam Drewnowski, Rudolph L. Leibel, Eric Ravussin, Leanne M. Redman, Michael W. Schwartz, Randy J. Seeley, Lori M. Zeltser

Clinical Research Faculty Publications

No abstract provided.

Effects Of Intermittent Fasting On Cardiometabolic Health: An Energy Metabolism Perspective, Manuel Dote-Montero, Guillermo Sanchez-Delgado, Eric Ravussin

Clinical Research Faculty Publications

This review summarizes the effects of different types of intermittent fasting (IF) on human cardiometabolic health, with a focus on energy metabolism. First, we discuss the coordinated metabolic adaptations (energy expenditure, hormonal changes and macronutrient oxidation) occurring during a 72 h fast. We then discuss studies investigating the effects of IF on cardiometabolic health, energy expenditure and substrate oxidation. Finally, we discuss how IF may be optimized by combining it with exercise. In general, IF regimens improve body composition, ectopic fat, and classic cardiometabolic risk factors, as compared to unrestricted eating, especially in metabolically unhealthy participants. However, it is still …

Exercise/Physical Activity In Individuals With Type 2 Diabetes: A Consensus Statement From The American College Of Sports Medicine, Jill A. Kanaley, Sheri R. Colberg, Matthew H. Corcoran, Steven K. Malin, Nancy R. Rodriguez, Carlos J. Crespo, John P. Kirwan, Juleen R. Zierath

Division of Basic Science Faculty Publications

This consensus statement is an update of the 2010 American College of Sports Medicine position stand on exercise and type 2 diabetes. Since then, a substantial amount of research on select topics in exercise in individuals of various ages with type 2 diabetes has been published while diabetes prevalence has continued to expand worldwide. This consensus statement provides a brief summary of the current evidence and extends and updates the prior recommendations. The document has been expanded to include physical activity, a broader, more comprehensive definition of human movement than planned exercise, and reducing sedentary time. Various types of physical …

The Precision Interventions For Severe And/Or Exacerbation-Prone (Precise) Asthma Network: An Overview Of Network Organization, Procedures, And Interventions, Steve N. Georas, Rosalind J. Wright, Anastasia Ivanova, Elliot Israel, Lisa M. Lavange, Praveen Akuthota, Tara F. Carr, Loren C. Denlinger, Merritt L. Fajt, Rajesh Kumar, Wanda K. O'Neal, Wanda Phipatanakul, Stanley J. Szefler, Mark A. Aronica, Leonard B. Bacharier, Allison J. Burbank, Mario Castro, Laura Crotty Alexander, Julie Bamdad, Juan Carlos Cardet, Suzy A.A. Comhair, Ronina A. Covar, Emily A. Dimango, Kim Erwin, Serpil C. Erzurum, John V. Fahy, Jonathan M. Gaffin, Benjamin Gaston, Lynn B. Gerald, Eric A. Hoffman, Fernando Holguin, Daniel J. Jackson, John James, Nizar N. Jarjour

Division of Basic Science Faculty Publications

Asthma is a heterogeneous disease, with multiple underlying inflammatory pathways and structural airway abnormalities that impact disease persistence and severity. Recent progress has been made in developing targeted asthma therapeutics, especially for subjects with eosinophilic asthma. However, there is an unmet need for new approaches to treat patients with severe and exacerbation-prone asthma, who contribute disproportionately to disease burden. Extensive deep phenotyping has revealed the heterogeneous nature of severe asthma and identified distinct disease subtypes. A current challenge in the field is to translate new and emerging knowledge about different pathobiologic mechanisms in asthma into patient-specific therapies, with the ultimate …

Biomass Slurry Fracture Injection As A Potential Low-Cost Negative Emissions Technology, Brian F. Snyder

Faculty Publications

Negative emissions technologies (NETs) are systems which remove carbon dioxide directly from the atmosphere and sequester it in permanent storage and they are required to meet the goals of the Paris Agreement. However, all NETs are limited by biological, physical and economic factors. Here, we model the life cycle emissions, geospatial potential, technoeconomic feasibility of a new NET based on slurry fracture injection, a technique which has been used for decades in the oil and gas industry to dispose of wastes. In the proposed system, called biomass slurry fracture injection (BSFI), biogeneic wastes are injected into fractures created in permeable …

South Holston Tailwater Trout Fishery Management Plan 2022-2027, Tennessee. Wildlife Resources Agency.

Strategic and Management Plans

No abstract provided.

Wilbur Tailwater Trout Fishery Management Plan 2022-2027, Tennessee. Wildlife Resources Agency.

Strategic and Management Plans

No abstract provided.

Love Without Limits

In Case You Missed It

FEBRUARY 2022

Methods For Detecting Per2:Luciferase Bioluminescence Rhythms In Freely Moving Mice, Blanca Martin-Burgos, Wanqi Wang, Ivana William, Selma Tir, Innus Mohammad, Reja Javed, Stormi Smith, Yilin Cui, Jessica Arzavala, Dalilah Mora, Ciearra B. Smith, Vincent Van Der Vinne, Penny C. Molyneux, Stephen C. Miller, David R. Weaver, Tanya L. Leise, Mary E. Harrington

Psychology: Faculty Publications

Circadian rhythms are driven by daily oscillations of gene expression. An important tool for studying cellular and tissue circadian rhythms is the use of a gene reporter, such as bioluminescence from the reporter gene luciferase controlled by a rhythmically expressed gene of interest. Here we describe methods that allow measurement of circadian bioluminescence from a freely moving mouse housed in a standard cage. Using a LumiCycle In Vivo (Actimetrics), we determined conditions that allow detection of circadian rhythms of bioluminescence from the PER2 reporter, PER2::LUC, in freely behaving mice. The LumiCycle In Vivo applies a background subtraction that corrects for …

Cell-Type-Specific Circadian Bioluminescence Rhythms In Dbp Reporter Mice, Ciearra B. Smith, Vincent Van Der Vinne, Eleanor Mccartney, Adam C. Stowie, Tanya L. Leise, Blanca Martin-Burgos, Penny C. Molyneux, Lauren A. Garbutt, Michael H. Brodsky, Alec J. Davidson, Mary E. Harrington, Robert Dallmann, David R. Weaver

Psychology: Faculty Publications

Circadian rhythms are endogenously generated physiological and molecular rhythms with a cycle length of about 24 h. Bioluminescent reporters have been exceptionally useful for studying circadian rhythms in numerous species. Here, we report development of a reporter mouse generated by modification of a widely expressed and highly rhythmic gene encoding D-site albumin promoter binding protein (Dbp). In this line of mice, firefly luciferase is expressed from the Dbp locus in a Cre recombinase-dependent manner, allowing assessment of bioluminescence rhythms in specific cellular populations. A mouse line in which luciferase expression was Cre-independent was also generated. The Dbp reporter alleles do …

Centered On Jesus: A Lenten Devotional From The Faculty Of Bethel University, Christopher Gehrz, Esther Shull, Carl Albing, Rebekah Bain, Andy Bramsen, Susan Leigh Brooks, Jeannine K. Brown, Michael Crawford, Julie Anne De Haan, Joy Doan, Dale Durie, Julie Finnern, Barrett Fisher, Joel Frederickson, Laura Gilbertson, Rhonda Gilbraith, Ann Holland, Stephen Hunt, Rachel Jorgensen, Patricia Kelly, Denise Muir Kjesbo, Marion H. Larson, Erik Leafblad, Elisabeth E. Lefebvre, Jim Lewis, Joyce Lemay, Alison Lo, Gary A. Long, Christopher Moore, Katherine Nevins, Pauline E. Nichols, Meredith Nyberg, Chad Osgood, Jeanine Parolini, Richard Peterson, Dan Ritchie, Matt Runion, Robin Rylaarsdam, Kristin E. Sandau, Sara L. H. Shady, Angela Shannon, Marta Shaw, Paula A.G. Soneral, Peter T. Vogt, Laura Wennstrom, Gloria Wiese, Brandon Winters, Yu-Li Chang Zacher, Nick Zeimet

Faculty Books

For the 2022 season of Lent, Bethel faculty and staff members collaborated to pen Centered on Jesus: A Lenten Devotional from the Faculty of Bethel University. The daily devotionals in Centered on Jesus are intended to help the Bethel community and anyone interested recenter before the cross during Lent. And the devotionals show how faculty across Bethel—each from his or her unique discipline—approach what it means to be a university centered on Jesus.

This collection of 47 devotionals written by 48 Bethel faculty and staff members span from Ash Wednesday through Holy Week and Easter. These contributions represent over …

Neurotoxicity: A Rare Side Effect Of Programmed Cell Death 1 (Pd-1) Inhibitors, Syed Ehsanullah, Syed Hasan, Faran S Polani, Syeda Zarmeena Rashid, Syed Ijlal Ahmed

Open Access Publications

Immunotherapy is a biological therapy that helps the body's immune system to fight against cancer cells. The Food and Drug Administration (FDA) approved the first immune checkpoint inhibitor in 2011. Since 2011, many immune checkpoint inhibitors have been approved. Programmed cell death 1 (PD-1) inhibitors are now commonly used in multiple malignancies due to their remarkable response. Thus, immune-related adverse events are now coming into the limelight due to the increasing use of PD-1 inhibitors. Here, we present a case of a 54-year-old female with non-small cell lung cancers (NSCLC) treated with pembrolizumab and later presented with severe neurotoxicity.

Macrophage Global Metabolomics Identifies Cholestenone As Host/Pathogen Cometabolite Present In Human Mycobacterium Tuberculosis Infection, Pallavi Chandra, Héloise Coullon, Mansi Agarwal, Charles W Goss, Jennifer A Philips

Open Access Publications

Mycobacterium tuberculosis (M. tuberculosis) causes an enormous burden of disease worldwide. As a central aspect of its pathogenesis, M. tuberculosis grows in macrophages, and host and microbe influence each other's metabolism. To define the metabolic impact of M. tuberculosis infection, we performed global metabolic profiling of M. tuberculosis-infected macrophages. M. tuberculosis induced metabolic hallmarks of inflammatory macrophages and a prominent signature of cholesterol metabolism. We found that infected macrophages accumulate cholestenone, a mycobacterial-derived, oxidized derivative of cholesterol. We demonstrated that the accumulation of cholestenone in infected macrophages depended on the M. tuberculosis enzyme 3β-hydroxysteroid dehydrogenase (3β-Hsd) and correlated with pathogen …

Identification Of Novel Mitochondrial Pyruvate Carrier Inhibitors By Homology Modeling And Pharmacophore-Based Virtual Screening, Lamees Hegazy, Lauren Gill, Kelly Pyles, Christopher Kaiho, Sophia Kchouk, Brian Finck, Kyle Mccommis, Bahaa Elgendy

Open Access Publications

No abstract provided.