Digital Commons Network^™

The Nexus Of Gut Microbiota, Diet, And Health, Sajal Bhattarai, Srinivas Janaswamy

Dairy Science and Food Science Faculty Publications: 2022 to Present

The gut microbiome incorporates the ecological niche specific to the totality of the microorganisms in the human gut. Unique to every individual, the blueprint of the microbiome sets up at birth and functions as a human organ and plays a significant role in digestion, detoxification, fighting pathogens, modulating the immune system, and improving health. The gut microbiota and associated health implications are influenced by factors such as birth and age, diseases, use of antibiotics and food components (e.g., complex carbohydrates and dietary fibers, plant proteins, unsaturated fatty acids, and functional compounds of natural origin such as flavones, flavonoids, polyphenols, and …

Parenting As Spiritual Practice And Source For Theology: Mothering Matters., Angela Mccarthy

Pastoral Liturgy

No abstract provided.

Pastoral Liturgy 52 (2) Complete Journal

Pastoral Liturgy

No abstract provided.

Ppld Is A De-N-Acetylase Of The Cell Wall Linkage Unit Of Streptococcal Rhamnopolysaccharides, Jeffrey S. Rush, Prakash Parajuli, Alessandro Ruda, Jian Li, Amol Arunrao Pohane, Svetlana Zamakhaeva, Mohammad M. Rahman, Jennifer C. Chang, Artemis Gogos, Cameron W. Kenner, Gérard Lambeau, Michael J. Federle, Konstantin V. Korotkov, Göran Widmalm, Natalia Korotkova

Molecular and Cellular Biochemistry Faculty Publications

The cell wall of the human bacterial pathogen Group A Streptococcus (GAS) consists of peptidoglycan decorated with the Lancefield group A carbohydrate (GAC). GAC is a promising target for the development of GAS vaccines. In this study, employing chemical, compositional, and NMR methods, we show that GAC is attached to peptidoglycan via glucosamine 1-phosphate. This structural feature makes the GAC-peptidoglycan linkage highly sensitive to cleavage by nitrous acid and resistant to mild acid conditions. Using this characteristic of the GAS cell wall, we identify PplD as a protein required for deacetylation of linkage N-acetylglucosamine (GlcNAc). X-ray structural analysis indicates …

A Deep Unsupervised Feature Learning Spiking Neural Network With Binarized Classification Layers For The Emnist Classification, Ruthvik Vaila, John Chiasson, Vishal Saxena

Electrical and Computer Engineering Faculty Publications and Presentations

End user AI is trained on large server farms with data collected from the users. With ever increasing demand for IoT devices, there is a need for deep learning approaches that can be implemented at the Edge in an energy efficient manner. In this work we approach this using spiking neural networks. The unsupervised learning technique of spike timing dependent plasticity (STDP) and binary activations are used to extract features from spiking input data. Gradient descent (backpropagation) is used only on the output layer to perform training for classification. The accuracies obtained for the balanced EMNIST data set compare favorably …

University Of Dayton Magazine, Spring 2022, University Of Dayton

University of Dayton Alumni Publications

The University of Dayton Magazine is published quarterly by the Office of University Marketing and Communications for alumni, parents, students, faculty/staff, trustees and other friends of UD.

2022 Darwin Day Lecture To Examine The Weapons From The Animal World, Alicia Rohan

Browse All News

No abstract provided.

Tremblings, February 2022, Western Aspen Alliance

Tremblings

Aspen: A Reason for Hope

Robert A. Andrus

Tens of millions of trees have died in recent decades in subalpine forests in the western US. Much of this tree mortality has been caused by two natural disturbances—wildfires and outbreaks of native insects (i.e., bark beetles). The loss of so many trees has left us wondering what is next for these areas. Will they return to forest and if so, what will they look like?

Reframing Global Biodiversity Protection After Covid-19: Is International Environmental Law Up To The Task?, Maria Antonia Tigre, Natalia Urzola, Victoria Lichet

Sabin Center for Climate Change Law

In an increasingly interdependent world, the climate and biodiversity crises are, more than ever, inextricably tied to human health and the transmission of infectious diseases. The 2020 Covid-19 pandemic has irrevocably shown us that the exploitation of wild species and deforestation increases and modifies the interface between people and wildlife, leading to a spillover of diseases from wildlife to people. From a legal perspective, the gaps in international environmental law have contributed to the lack of an effective international biodiversity policy. In light of the challenges brought by the pandemic, there is now an opportunity to rethink our existing legal …

Predicting Online Sexual Victimization Among College Students: Sexting, Solicitations, And Other Risky Online Behaviors, Tianna Joy Knight

Masters Theses

With the high prevalence rates of internet usage and smartphone ownership, risky online behaviors have become more and more widespread. These behaviors include sexting, online sexual solicitations, and online sexual interactions. Research indicates that these risky behaviors are related to online sexual victimization (OSV). OSV has been associated with poorer mental health, loneliness, lower life satisfaction, and other negative outcomes. Another phenomenon linked to OSV and sexting is sexual exploitation, but no study has yet analyzed the predictive ability of beliefs and awareness about sexual exploitation and human trafficking on OSV. Optimism bias, or the tendency to think that one’s …

Ras-Mediated Tumor Stress Adaptation And The Targeting Opportunities It Presents, Alexandra Redding, A E Aplin, Elda Grabocka

Department of Cancer Biology Faculty Papers

Cellular stress is known to function in synergistic cooperation with oncogenic mutations during tumorigenesis to drive cancer progression. Oncogenic RAS is a strong inducer of a variety of pro-tumorigenic cellular stresses, and also enhances the ability of cells to tolerate these stresses through multiple mechanisms. Many of these oncogenic, RAS-driven, stress-adaptive mechanisms have also been implicated in tolerance and resistance to chemotherapy and to therapies that target the RAS pathway. Understanding how oncogenic RAS shapes cellular stress adaptation and how this functions in drug resistance is of vital importance for identifying new therapeutic targets and therapeutic combinations to treat RAS-driven …

Forage News [2022-02], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

No abstract provided.

Reykjanes Mantle Convection And Climate: Crustal Objectives, Ross E. Parnell-Turner, Anne R. Briais, Leah J. Levay, Ying Cui, Anita Di Chiara, Justin P. Dodd, Deborah E. Eason, Sarah A. Friedman, Katharina E. Hochmuth, Boris T. Karatsolis, Danielle E. Leblanc, Melody R. Lindsay, David D. Mcnamara, Sevasti E. Modestou, Bramley Murton, Suzanne B. O’Connell, Gabriel T. Pasquet, Paul N. Pearson, Sheng Ping Qian, Yair Rosenthal, Sara Satolli, Jose M. Cuevas, Jamie L. Shamrock, Takuma Suzuki, Saalim M. Syed, Nicholas J. White, Alexandra Yang Yang

Department of Earth and Environmental Studies Faculty Scholarship and Creative Works

The five primary sites proposed for International Ocean Discovery Program (IODP) Expedition 395, which was postponed because of the COVID-19 pandemic, were cored during IODP Expedition 395C. The Expedition 395C operations, shipboard measurements, and sampling were adjusted to account for the absence of a sailing science party. The Expedition 395/395C objectives are (1) to investigate temporal variations in ocean crust generation at the Reykjanes Ridge and test hypotheses for the influence of Iceland mantle plume fluctuations on these processes, (2) to analyze sedimentation rates at the Björn and Gardar contourite drifts, as proxies for Cenozoic variations of North Atlantic deepwater …

Perspective Of Dairy Producers From California, Idaho, South Dakota, And Washington: Health And Business Implications Of The Covid-19 Pandemic During The Second Wave, Ainhoa Valldecabres, J. Wenz, Fernanda Ferreira, Mireille Chahine, Joseph Dalton, Mario E. De Haro-Martí, Maristela Rovai, Noelia Silva-Del-Rio

Dairy Science and Food Science Faculty Publications: 2022 to Present

The aim of this study was to document California, Idaho, South Dakota, and Washington dairy producers' perspectives on the health and business implications of COVID-19 during the pandemic second wave. Dairy producers were reached by a 14-question anonymous mail survey during June and July of 2020. We obtained 226 responses (response rate: 9.3% CA, 8.6% ID, 31.4%, and 10.0% WA). Responses were grouped by state (CA: 48.7%, ID: 15.9%, SD: 21.7%, or WA: 13.7%) and dairy size [based on number of cows; small (<100): 14.1%, medium (100–499): 27.7%, medium-large (500–1,999): 33.2%, or large (≥2,000): 25.0%]. Survey responses were summarized, and multiple correspondence analysis was used to map responses and identify data clusters. At the time of the survey, some respondents suspected (3%) or had confirmed (9%) COVID-19 cases on their premises. Respondents were somewhat or very concerned about the health (75%) and business (92%) implications associated with COVID-19. Producers were concerned about the health of their families, employees, and employees' families; having to reduce production; workforce shortage; limited goods availability; and lack of services. Producers perceived that their employees were somewhat or very concerned (74%) with the pandemic. There was COVID-19 safety information or training provided (78%) or intended (4%) in English (22%), Spanish (23%), or both (55%). The focus of training was as follows: how to remain healthy at work (91%) and at home (60%), what to do if a worker gets sick (77%), and sick leave information (54%). Nevertheless, 18% of the respondents answered that training was not going to be provided. The following control measures implemented: providing hand sanitizer or disinfectant wipes (78%), instruction on frequent hand-washing (76%), social distancing (59%), prevention of employee gatherings (54%), providing and requiring the use of face masks (49%), and limiting on-farm visitors (44%). Multiple correspondence analysis showed that concern with health …

Corrigendum To "Unraveling The Mechanobiology Of Immune Cells" [Curr Opin Biotechnol 66 (2020) 236-245], Xuexiang Zhang, Tae-Hyung Kim, Timothy J. Thauland, Hongjun Li, Fatemeh Sadat Majedi, Chau Ly, Zhen Gu, Manish J. Butte, Amy C. Rowat, Song Li

Pathology Research and Scholarship

Immune cells can sense and respond to biophysical cues — from dynamic forces to spatial features — during their development, activation, differentiation and expansion. These biophysical signals regulate a variety of immune cell functions such as leukocyte extravasation, macrophage polarization, T cell selection and T cell activation. Recent studies have advanced our understanding on immune responses to biophysical cues and the underlying mechanisms of mechanotransduction, which provides rational basis for the design and development of immune-modulatory therapeutics. This review discusses the recent progress in mechanosensing and mechanotransduction of immune cells, particularly monocytes/macrophages and T lymphocytes, and features new biomaterial designs …

Prostacyclin Promotes Degenerative Pathology In A Model Of Alzheimer’S Disease, Tasha R. Womack, Craig T. Vollert, Odochi Ohia-Nwoko, Monika Schmitt, Saghi Montazari, Tina L. Beckett, David Mayerich, Michael Paul Murphy, Jason L. Eriksen

Sanders-Brown Center on Aging Faculty Publications

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is the most common form of dementia in aged populations. A substantial amount of data demonstrates that chronic neuroinflammation can accelerate neurodegenerative pathologies. In AD, chronic neuroinflammation results in the upregulation of cyclooxygenase and increased production of prostaglandin H2, a precursor for many vasoactive prostanoids. While it is well-established that many prostaglandins can modulate the progression of neurodegenerative disorders, the role of prostacyclin (PGI2) in the brain is poorly understood. We have conducted studies to assess the effect of elevated prostacyclin biosynthesis in a mouse model of AD. Upregulated prostacyclin expression …

2021 Soybean Insect Losses In The United States, Fred R. Musser, Angus L. Catchot Jr., Jeffrey A. Davis, Christina Difonzo, Scott H. Graham, Jeremy K. Greene, Bryan Jensen, David L. Kerns, Robert L. Koch, David Owens, Dominic D. Reisig, Phillip M. Roberts, Tom A. Royer, Nicholas J. Seiter, Scott D. Stewart, Sally V. Taylor, Benjamin C. Thrash, Kelley J. Tilmon, Raul T. Villanueva

Midsouth Entomologist

Estimated insect management costs and losses due to insects in soybean during the 2021 growing season were collected and compiled from 18 states to provide a record of insect pressure and management practices for the year. These annual estimates provide a historical record of pest pressure and insect management and have been compiled in some states since 2004. Participating states represented 47% of soybean acreage grown in the United States, with near 100% participation in southern states. Overall, the stink bug complex was the costliest insect pest in soybean followed by corn earworm. Total insect management costs were $18.53 per …

Five Auguries, Carolyn Decker

The Lindenwood Review: a journal of literary prose

No abstract provided.

Contributors

The Lindenwood Review: a journal of literary prose

No abstract provided.

Strategies For Early Learners, D.R. Meece

Open Textbooks

NEWER EDITION AVAILABLE: https://scholar.utc.edu/open-textbooks/6 Welcome to learning about how to effectively plan curriculum for young children. This textbook will address: • Developing curriculum through the planning cycle • Theories that inform what we know about how children learn and the best ways for teachers to support learning • The three components of developmentally appropriate practice • Importance and value of play and intentional teaching • Different models of curriculum • Process of lesson planning (documenting planned experiences for children) • Physical, temporal, and social environments that set the stage for children’s learning • Appropriate guidance techniques to support children’s behaviors …

February 1, 2022, Faculty Senate

Minutes

No abstract provided.

Inhibition Of Interferon-Gamma-Stimulated Melanoma Progression By Targeting Neuronal Nitric Oxide Synthase (Nnos), Shirley Tong, Maris A. Cinelli, Naglaa Salem El-Sayed, He Huang, Anika Patel, Richard B. Silverman, Sun Yang

Pharmacy Faculty Articles and Research

Interferon-gamma (IFN-γ) is shown to stimulate melanoma development and progression. However, the underlying mechanism has not been completely defined. Our study aimed to determine the role of neuronal nitric oxide synthase (nNOS)-mediated signaling in IFN-γ-stimulated melanoma progression and the anti-melanoma effects of novel nNOS inhibitors. Our study shows that IFN-γ markedly induced the expression levels of nNOS in melanoma cells associated with increased intracellular nitric oxide (NO) levels. Co-treatment with novel nNOS inhibitors effectively alleviated IFN-γ-activated STAT1/3. Further, reverse phase protein array (RPPA) analysis demonstrated that IFN-γ induced the expression of HIF1α, c-Myc, and programmed death-ligand 1 (PD-L1), in contrast …

Prediction Of Soil Water Content And Electrical Conductivity Using Random Forest Methods With Uav Multispectral And Ground-Coupled Geophysical Data, Yunyi Guan, Katherine R. Grote, Joel Schott, Kelsi Leverett

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

The volumetric water content (VWC) of soil is a critical parameter in agriculture, as VWC strongly influences crop yield, provides nutrients to plants, and maintains the microbes that are needed for the biological health of the soil. Measuring VWC is difficult, as it is spatially and tempo-rally heterogeneous, and most agricultural producers use point measurements that cannot fully capture this parameter. Electrical conductivity (EC) is another soil parameter that is useful in agricul-ture, since it can be used to indicate soil salinity, soil texture, and plant nutrient availability. Soil EC is also very heterogeneous; measuring EC using conventional soil sampling …

Orphan Antiquities At Kenyon College: The Lessons Of The Harris Bequest, Elizabeth Marlowe

Peregrinations: Journal of Medieval Art and Architecture

No abstract provided.

Parallel Computing Framework And Gpu Performance Modeling, Wenjing Xu

Doctoral Dissertations

During the past decades, High-Performance Computing (HPC) has been widely used in various industries. In particular, the exponential growth of GPU (graphics processing unit) is a key technology that has helped promoting the development of artificial intelligence in real-world use cases. When we use GPU to accelerate parallel applications, its programmability, resource management, and scheduling are non-trivial jobs to obtain optimized performance. Therefore, how to effectively exploit GPU resources and improve program performance has been a hot research topic recently.

Benchmark does not always provide a good picture of the performance and details of the parallel applications. The various kinds …

Spells, Beth Mattson

The Lindenwood Review: a journal of literary prose

No abstract provided.

Incorporating Microtopography In A Land Surface Model And Quantifying The Effect On The Carbon Cycle, J. D. Graham, D. M. Ricciuto, N. F. Glenn, P. J. Hanson

Geosciences Faculty Publications and Presentations

Northern peatlands are a terrestrial carbon store, with an annual sink of 0.1 Pg C yr⁻¹ and a total storage estimate of 547 Pg C. Northern peatlands are also major contributors of atmospheric methane. Most land surface models do not accurately represent peatland carbon emissions, partly because they do not represent the hydrologic cycle and/or microtopography adequately. Interactions between water table depth and microtopography in peatlands influence decomposition and modulate CO₂ and CH₄ fluxes. A modified version of the land surface component of the Energy Exascale Earth System Model, was recently created to represent the microtopography and …

Paths Of Coexistence: Spatially Predicting Acceptance Of Grizzly Bears Along Key Movement Corridors, Abigail H. Sage, Vicken Hillis, Rose A. Graves, Morey Burnham, Neil H. Carter

Human-Environment Systems Research Center Faculty Publications and Presentations

Landscape connectivity is important for conserving wildlife in spaces shared with humans. Yet, differences in human attitudes and behaviors within movement corridors can lead to spatial variation in the risks humans pose to wildlife. Mapping the spatial pattern of attitudes toward wildlife provides a useful tool for measuring this variation and promoting connectivity. We surveyed ranchers (n = 505) in the High Divide region in eastern Idaho and western Montana (United States) about their attitudes toward grizzly bears (Ursus arctos) – a species that can pose risks to livestock and human safety. We assessed spatial variation in …

Regulatory T Cells Control Effector T Cell Inflammation In Human Prediabetes, Rui Liu, Gabriella H. Pugh, Erin Tevonian, Katherine Thompson, Douglas A. Lauffenburger, Philip A. Kern, Barbara S. Nikolajczyk

Clinical and Translational Science Faculty Publications

A disparate array of plasma/serum markers provides evidence for chronic inflammation in human prediabetes, a condition that is most closely replicated by standard mouse models of obesity and metaflammation. These remain largely nonactionable and contrast with our rich understanding of inflammation in human type 2 diabetes. New data show that inflammatory profiles produced by CD4+ T cells define human prediabetes as a unique inflammatory state. Regulatory T cells (Treg) control mitochondrial function and cytokine production by CD4+ effector T cells (Teff) in prediabetes and type 2 diabetes by supporting T helper (Th)17 or Th1 cytokine production, respectively. These data suggest …

Chemistry Matters February 2022, Otterbein University Chemistry Department

Chemistry Matters Department Newsletter

In this Issue:

Letter from the Chair, Faculty Scholarship, Chemistry in Action, Structural Methods in Chemistry, Summer Student Work, New Instrumentation Supports Student Learning, Post-COVID Adjustments in 2020 and Beyond, Otterbein University Students Benefit from Faculty Involvement in National Organizations, and Otterbein Student Chapter of ACS Nationally Recognized for the Second Year in a Row