Digital Commons Network^™

Global Assessment Of Grassland Carrying Capacities And Relative Stocking Densities Of Livestock, J. Piipponen, M. Jalava, J. De Leeuw, A. Rizayeva, C. Godde, M. Herrero, M. Kummu

IGC Proceedings (1977-2023)

Although many suggest that future diets should include more plant-based proteins, animal-sourced foods are unlikely to completely disappear from our diet. Grasslands yield a notable part of the world’s animal protein production, but thus far, there is no global insight into the relationship between current livestock stocking densities and the availability of grassland forage resources. This inhibits acting upon concerns over the negative effects of overgrazing in some areas and utilising the potential for increasing production in others. Previous research has examined the potential of sustainable grazing but lacks generic and observation-based methods needed to fully understand the opportunities and …

Genetic Diversity Among And Within Accessions Of A Lablab (Lablab Purpureus) Collection Maintained In The Ilri Forage Genebank, M. S. Muktar, A. M. Sartie, A. T. Negawo, E. Habte, C. S. Jones

IGC Proceedings (1977-2023)

Lablab (Lablab purpureus L.) is an important annual multi-purpose legume used as a vegetable for human consumption, as forage for livestock, and as green manure and a cover crop to improve soil fertility. It has a high feed value with good digestibility and high crude protein content. The International Livestock Research Institute (ILRI) forage genebank holds a diverse set of 340 lablab accessions collected from different regions of the world. A total of 1,843 plants from 142 lablab accessions (1 to 29 plants per accession genotyped individually) were genotyped by the genotyping-by-sequencing (GBS) method of the DArTseq platform. The …

Book Reviews

Great Plains Sociologist

Geoffrey W. Grant
Crime in Biological, Social, and Moral Contexts
Lee Ellis and Harry Hoffnan (Eds.)

Thomas C. Langham
Sociological Practice: Community Development and Other Community Applications, Volume 8
Alvin S. Lackey (Ed.)

Jerome R. Rosonke
Mirrors of Madness: Patrolling the Psychic Border
Bruce Luske

Kathleen A. Tiemann
Social Control and Deviance: A Critical Approach
Nanette J. Davis and Clarice Stasz

Harry Hoffman
Can Modernity Survive?
Agnes Heller

Janet Kelly Moen
Basics of Qualitative Research: Grounded Theory Procedures and Techniques
Anselm Strauss and Juliet Corbin

Patricia Ann Wasely Lomir
The Sociology of Gender
Laura Kramer (Ed.)

John Flanagin
Maiginal …

Front Matter, Clifford L. Staples

Great Plains Sociologist

Front Matter

Estimating The Glutamate Transporter Surface Density In Distinct Sub-Cellular Compartments Of Mouse Hippocampal Astrocytes, Annalisa Scimemi, Damian G. Zuloaga, Ashley M. Kopec, Justin R. Bourgeois, Haley E. Chesbro, Alex A. Lemus, Benjamin A. Bennink, Cassandra L. Williams, Gabrielle C. Todd, Anca R. Radulescu

Biological Sciences Faculty Scholarship

Glutamate transporters preserve the spatial specificity of synaptic transmission by limiting glutamate diffusion away from the synaptic cleft, and prevent excitotoxicity by keeping the extracellular concentration of glutamate at low nanomolar levels. Glutamate transporters are abundantly expressed in astrocytes, and previous estimates have been obtained about their surface expression in astrocytes of the rat hippocampus and cerebellum. Analogous estimates for the mouse hippocampus are currently not available. In this work, we derive the surface density of astrocytic glutamate transporters in mice of different ages via quantitative dot blot. We find that the surface density of glial glutamate transporters is similar …

February 4, 2022 Board Of Trustees Meeting Report, Board Of Trustees

Board of Trustees

No abstract provided.

Environmental Science Alumnus Works To Restore Groundwater Quality, Taylor University

2022 Website News Stories

No abstract provided.

February 4, 2022 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Interactions Between Strains Govern The Eco-Evolutionary Dynamics Of Microbial Communities, Akshit Goyal, Leonora S. Bittleston, Gabriel E. Leventhal, Lu Lu, Otto X. Cordero

Biology Faculty Publications and Presentations

Genomic data has revealed that genotypic variants of the same species, that is, strains, coexist and are abundant in natural microbial communities. However, it is not clear if strains are ecologically equivalent, and at what characteristic genetic distance they might exhibit distinct interactions and dynamics. Here, we address this problem by tracking 10 taxonomically diverse microbial communities from the pitcher plant Sarracenia purpurea in the laboratory for more than 300 generations. Using metagenomic sequencing, we reconstruct their dynamics over time and across scales, from distant phyla to closely related genotypes. We find that most strains are not ecologically equivalent and …

Prkci Regulates Autophagy And Pancreatic Tumorigenesis In Mice, Kristin S. Inman, Yi Liu, Michele L. Scotti Buzhardt, Michael Leitges, Murli Krishna, Howard C. Crawford, Alan P. Fields, Nicole R. Murray

Research Administration Articles

Protein kinase C iota (PKCι) functions as a bonafide human oncogene in lung and ovarian cancer and is required for Kras(G12D)-mediated lung cancer initiation and progression. PKCι expression is required for pancreatic cancer cell growth and maintenance of the transformed phenotype; however, nothing is known about the role of PKCι in pancreas development or pancreatic tumorigenesis. In this study, we investigated the effect of pancreas-specific ablation of PKCι expression on pancreatic cellular homeostasis, susceptibility to pancreatitis, and Kras(G12D)-mediated pancreatic cancer development. Knockout of pancreatic Prkci significantly increased pancreatic immune cell infiltration, acinar cell DNA damage, and apoptosis, but reduced sensitivity …

Public Policy Should Foster Alzheimer’S Treatment Availability: Comment On The Draft Us Medicare Decision To Limit Payment For Aducanumab (Aduhelm™) To Patients Participating In Clinical Trials, Jeffrey L. Cummings

Brain Health Faculty Research

Aducanumab (AduhelmTM) was approved by the United States (US) Food and Drug Administration (FDA) for the treatment of Alzheimer’s disease on June 7, 2021. Soon after, the approved labeling was adjusted to direct treatment to mild cognitive impairment (MCI) due to Alzheimer’s disease (AD) and mild AD dementia reflecting the severity of cognitive impairment among participants in the clinical trials that led to the approval (1, 2).

Individuals over age 65 in the US are entitled to have the cost of prescription drugs partially paid by the Center for Medicare and Medicaid Services (CMS; “Medicare”) if they participate in an …

A Versatile Contribution Of Both Aminopeptidases N And Abc Transporters To Bt Cry1ac Toxicity In The Diamondback Moth, Dan Sun, Liuhong Zhu, Le Guo, Shaoli Wang, Qingjun Wu, Neil Crickmore, Xuguo Zhou, Alejandra Bravo, Mario Soberón, Zhaojiang Guo, Youjun Zhang

Entomology Faculty Publications

BACKGROUND: Biopesticides and transgenic crops based on Bacillus thuringiensis (Bt) toxins are extensively used to control insect pests, but the rapid evolution of insect resistance seriously threatens their effectiveness. Bt resistance is often polygenic and complex. Mutations that confer resistance occur in midgut proteins that act as cell surface receptors for the toxin, and it is thought they facilitate its assembly as a membrane-damaging pore. However, the mechanistic details of the action of Bt toxins remain controversial.

RESULTS: We have examined the contribution of two paralogous ABC transporters and two aminopeptidases N to Bt Cry1Ac toxicity in the diamondback moth, …

A Quantitative Study Examining Intentional Teaching Of Social Emotional Skills, Christina Scrivner Huse

Dissertations

In a world where children are likely to experience early-life trauma, relationships matter, and trust is a key in forming healthy working relationships. Intentionally teaching adults and teachers how to evoke calmness in ourselves and breathe to handle negative situations, trusted educators can then teach children to do the same. It is important that educational leaders, and other stakeholders, explore what works best to help children overcome trauma and become resilient and productive adults. This study examined the relationship between social, emotional, and behavioral skills of students entering kindergarten who have been intentionally taught skills needed for resiliency by highly …

Multiple Approaches Converge On Three Biological Subtypes Of Meningioma And Extract New Insights From Published Studies, James C Bayley, Caroline C Hadley, Arif O Harmanci, Akdes S Harmanci, Tiemo J Klisch, Akash J Patel

Faculty, Staff and Student Publications

One-fifth of meningiomas classified as benign by World Health Organization (WHO) histopathological grading will behave malignantly. To better diagnose these tumors, several groups turned to DNA methylation, whereas we combined RNA-sequencing (RNA-seq) and cytogenetics. Both approaches were more accurate than histopathology in identifying aggressive tumors, but whether they revealed similar tumor types was unclear. We therefore performed unbiased DNA methylation, RNA-seq, and cytogenetic profiling on 110 primary meningiomas WHO grade I and II). Each technique distinguished the same three groups (two benign and one malignant) as our previous molecular classification; integrating these methods into one classifier further improved accuracy. Computational …

Optimizing Management Of Invasions In An Uncertain World Using Dynamic Spatial Models, Kim M. Pepin, Amy J. Davis, Rebecca S. Epanchin-Niell, Andrew M. Gormley, Joslin L. Moore, Timothy J. Smyser, H. Bradley Shaffer, William L. Kendall, Katriona Shea, Michael C. Runge, Sophie Mckee

United States Department of Agriculture Wildlife Services: Staff Publications

Dispersal drives invasion dynamics of nonnative species and pathogens. Applying knowledge of dispersal to optimize the management of invasions can mean the difference between a failed and a successful control program and dramatically improve the return on investment of control efforts. A common approach to identifying optimal management solutions for invasions is to optimize dynamic spatial models that incorporate dispersal. Optimizing these spatial models can be very challenging because the interaction of time, space, and uncertainty rapidly amplifies the number of dimensions being considered. Addressing such problems requires advances in and the integration of techniques from multiple fields, including ecology, …

Protocol For Development Of A Core Outcome Set For Clinical Trials In Melasma, Sarah Ibrahim, Bianca Kang, Daniel Schlessinger, Sarah Chiren, Jennifer Tang, Jamie Kirkham, Jochen Schmitt, Emily Poon, Ian Maher, Joseph Sobanko, Todd Cartee, Murad Alam

Open Access Publications

INTRODUCTION: Melasma is a pigmentation disorder of the skin. Characterised by brown to gray-brown patches on the face and neck, the condition predominantly affects women and has been associated with pregnancy, hormonal variation and sun exposure. Melasma can be disfiguring and anxiety-provoking, and quality of life is often adversely impacted. Management includes sun protection, laser and energy device therapy, topical and oral skin-bleaching agents and chemical peels. While clinical trials of melasma exist, there is a lack of consistency in reported outcomes, which has been a barrier to the aggregation of data in systematic reviews and meta-analyses. This protocol describes …

Using Smartphones To Reduce Research Burden In A Neurodegenerative Population And Assessing Participant Adherence: A Randomized Clinical Trial And Two Observational Studies, Anna L Beukenhorst, Katherine M Burke, Zoe Scheier, Timothy M Miller, Sabrina Paganoni, Mackenzie Keegan, Ella Collins, Kathryn P Connaghan, Anna Tay, James Chan, James D Berry, Jukka-Pekka Onnela

Open Access Publications

BACKGROUND: Smartphone studies provide an opportunity to collect frequent data at a low burden on participants. Therefore, smartphones may enable data collection from people with progressive neurodegenerative diseases such as amyotrophic lateral sclerosis at high frequencies for a long duration. However, the progressive decline in patients' cognitive and functional abilities could also hamper the feasibility of collecting patient-reported outcomes, audio recordings, and location data in the long term.

OBJECTIVE: The aim of this study is to investigate the completeness of survey data, audio recordings, and passively collected location data from 3 smartphone-based studies of people with amyotrophic lateral sclerosis.

METHODS: …

Interplay Between Soluble Cd74 And Macrophage-Migration Inhibitory Factor Drives Tumor Growth And Influences Patient Survival In Melanoma, Yasunari Fukuda, Matias A Bustos, Sung-Nam Cho, Jason Roszik, Suyeon Ryu, Victor M Lopez, Jared K Burks, Jeffrey E Lee, Elizabeth A Grimm, Dave S B Hoon, Suhendan Ekmekcioglu

Faculty, Staff and Student Publications

Soluble forms of receptors play distinctive roles in modulating signal-transduction pathways. Soluble CD74 (sCD74) has been identified in sera of inflammatory diseases and implicated in their pathophysiology; however, few relevant data are available in the context of cancer. Here we assessed the composition and production mechanisms, as well as the clinical significance and biological properties, of sCD74 in melanoma. Serum sCD74 levels were significantly elevated in advanced melanoma patients compared with normal healthy donors, and the high ratio of sCD74 to macrophage-migration inhibitory factor (MIF) conferred significant predictive value for prolonged survival in these patients (p = 0.0035). Secretion of …

Identification Of Distinct Characteristics Of Antibiofilm Peptides And Prospection Of Diverse Sources For Efficacious Sequences, Bipasa Bose, Taylor Downey, Anand K. Ramasubramanian, David C. Anastasiu

Faculty Research, Scholarly, and Creative Activity

A majority of microbial infections are associated with biofilms. Targeting biofilms is considered an effective strategy to limit microbial virulence while minimizing the development of antibiotic resistance. Toward this need, antibiofilm peptides are an attractive arsenal since they are bestowed with properties orthogonal to small molecule drugs. In this work, we developed machine learning models to identify the distinguishing characteristics of known antibiofilm peptides, and to mine peptide databases from diverse habitats to classify new peptides with potential antibiofilm activities. Additionally, we used the reported minimum inhibitory/eradication concentration (MBIC/MBEC) of the antibiofilm peptides to create a regression model on top …

The Student Movement Volume 106 Issue 12: Snowstorm Landon Takes A Seat At Andrews University, Caryn Cruz, Lauren Kim, Grace No, Megan Napod, Solana Campbell, Andrew Pak, Caralynn Chan, Chris Ngugi, Nathan Mathieu, Alexander Navarro, Evin N. Musgrove, Abraham Bravo, Isabella Koh, Gloria Oh, Elianna Fisher, Alannah Tjhatra

The Student Movement v. 106 (2021-2022)

HUMANS

Andrews Students and their Majors, Interviewed by: Caryn Cruz

AUSA Talent Show Winner: Christine Neveu-Cathian, Interviewed by: Lauren Kim

Exploring Andrews University History with CIC Grant, Grace No

ART & ENTERTAINMENT

Art Analysis: "it doesn't make a sound" by Andrew Pak, Interviewed by: Megan Napod

Inspired Fashion for the Winter Season, Solana Campbell

Winter Band Concert, Andrew Pak

NEWS

AUSA Sabbath: "The Pursuit", Caralynn Chan

Blood: A National Emergency, and How You Can Help Today, Chris Ngugi

Week of Prayer: The Event for the Weak and Weary, Nathan Mathieu

IDEAS

Charging into the Future: Are Electric Cars Worth It?, …

A Microfluidic Approach For Synthesis And Kinetic Profiling Of Branched Gold Nanostructures, Qi Cai, Valentina Castagnola, Luca Boselli, Alirio Moura, Hender Lopez, Wei Zhang, João M. De Araújo, Kenneth A. Dawson

Articles

Automatized approaches for nanoparticle synthesis and characterization represent a great asset to their applicability in the biomedical field by improving reproducibility and standardization, which help to meet the selection criteria of regulatory authorities. The scaled-up production of nanoparticles with carefully defined characteristics, including intrinsic morphological features, and minimal intra-batch, batch-to-batch, and operator variability, is an urgent requirement to elevate nanotechnology towards more trustable biological and technological applications. In this work, microfluidic approaches were employed to achieve fast mixing and good reproducibility in synthesizing a variety of gold nanostructures. The microfluidic setup allowed exploiting spatial resolution to investigate the growth evolution …

Building A Quantum Engineering Undergraduate Program, Abraham Asfaw, Alexandre Blais, Kenneth R. Brown, Jonathan Candelaria, Christopher Cantwell, Lincoln D. Carr, Joshua Combes, Dripto M. Debroy, John M. Donohue, Sophia E. Economou, Emily Edwards, Michael F. J. Fox, Steven M. Girvin, Alan Ho, Hilary M. Hurst, Zubin Jacob, Blake R. Johnson, Ezekiel Johnston-Halperin, Robert Joynt, Eliot Kapit, Judith Klein-Seetharaman, Martin Laforest, H. J. Lewandowski, Theresa W. Lynn, Corey Rae H. Mcrae, Celia Merzbacher, Spyridon Michalakis, Prineha Narang, William D. Oliver, Jens Palsberg, David P. Pappas, Michael G. Raymer, David J. Reilly, Mark Saffman, Thomas A. Searles, Jeffrey H. Shapiro, Chandralekha Singh

Faculty Research, Scholarly, and Creative Activity

Contribution: A roadmap is provided for building a quantum engineering education program to satisfy U.S. national and international workforce needs.

Background: The rapidly growing quantum information science and engineering (QISE) industry will require both quantum-aware and quantum-proficient engineers at the bachelor's level.

Research Question: What is the best way to provide a flexible framework that can be tailored for the full academic ecosystem?

Methodology: A workshop of 480 QISE researchers from across academia, government, industry, and national laboratories was convened to draw on best practices; representative authors developed this roadmap.

Findings: 1) For quantum-aware engineers, …

The Role Of Decorin Proteoglycan In Mitophagy., Thomas Neill, Renato V. Iozzo

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Proteoglycans are emerging as critical regulators of intracellular catabolism. This rise in prominence has transformed our basic understanding and alerted us to the existence of non-canonical pathways, independent of nutrient deprivation, that potently control the autophagy downstream of a cell surface receptor. As a member of the small leucine-rich proteoglycan gene family, decorin has single-handedly pioneered the connection between extracellular matrix signaling and autophagy regulation. Soluble decorin evokes protracted endothelial cell autophagy via Peg3 and breast carcinoma cell mitophagy via mitostatin by interacting with VEGFR2 or the MET receptor tyrosine kinase, respectively. In this paper, we give a mechanistic perspective …

Mir-196a Upregulation Contributes To Gefitinib Resistance Through Inhibiting Gltp Expression, Bing-Jie Liu, Fang-Fang Li, Yun-Xia Xie, Chong-Yuan Fan, Wen-Jing Liu, Jian-Ge Qiu, Bing-Hua Jiang

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Tyrosine kinase inhibitor (TKI) therapy has greatly improved lung cancer survival in patients with epidermal growth factor receptor (EGFR) mutations. However, the development of TKI-acquired resistance is the major problem to be overcome. In this study, we found that miR-196a expression was greatly induced in gefitinib-resistant lung cancer cells. To understand the role and mechanism of miR-196a in TKI resistance, we found that miR-196a-forced expression alone increased cell resistance to gefitinib treatment in vitro and in vivo by inducing cell proliferation and inhibiting cell apoptosis. We identified the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) bound to the …

Imaging-Based Screening Of Deubiquitinating Proteases Identifies Otubain-1 As A Stabilizer Of C-Myc, Shannon E Moree, Laure Maneix, Polina Iakova, Fabio Stossi, Ergun Sahin, Andre Catic

Faculty, Staff and Students Publications

The ubiquitin-proteasome pathway precisely controls the turnover of transcription factors in the nucleus, playing an important role in maintaining appropriate quantities of these regulatory proteins. The transcription factor c-MYC is essential for normal development and is a critical cancer driver. Despite being highly expressed in several tissues and malignancies, the c-MYC protein is also continuously targeted by the ubiquitin-proteasome pathway, which can either facilitate or inhibit c-MYC degradation. Deubiquitinating proteases can remove ubiquitin chains from target proteins and rescue them from proteasomal digestion. This study sought to determine novel elements of the ubiquitin-proteasome pathway that regulate c-MYC levels. We performed …

Highly Reliable Creation Of Floxed Alleles By Electroporating Single-Cell Embryos, Monica F Sentmanat, J Michael White, Evguenia Kouranova, Xiaoxia Cui

2020-Current year OA Pubs

BACKGROUND: Floxed (flanked by loxP) alleles are a crucial portion of conditional knockout mouse models. However, an efficient and reliable strategy to flox genomic regions of any desired size is still lacking.

RESULTS: Here, we demonstrate that the method combining electroporation of fertilized eggs with gRNA/Cas9 complexes and single-stranded oligodeoxynucleotides (ssODNs), assessing phasing of loxP insertions in founders using an in vitro Cre assay and an optional, highly specific and efficient second-round targeting ensures the generation of floxed F1 animals in roughly five months for a wide range of sequence lengths (448 bp to 160 kb reported here).

CONCLUSIONS: Floxed …

Evaluation Of Microbial Biomass In Agroforestry Systems Using Forage Cactus And Leucaena Leucocephala And Gliricidia Sepium, Dayanne Camelo, José C. B. Dubeux Jr., Mario De Andrade Lira Jr., Mércia V. F. Dos Santos, Diana Valadares Pessoa, Erick Santos

IGC Proceedings (1977-2023)

Vegetation type can affect soil microbiology in agroforestry systems. Plants release different organic exudates in the rhizosphere, affecting microbial growth. This study evaluated the effect of forage cactus intercropped with different tree legumes on soil microbial biomass. The research was performed in a tropical semiarid Regosol at Caruaru Experimental Station, Agronomic Institute of Pernambuco, Northeast Brazil. Treatments included: i) Gliricidia sepium (Jacq.) Steud and forage cactus IPA-Sertânia (Nopalea cochenillifera Salm Dyck); and ii) Leucaena leucocephala [Lam.] de Wit.) and forage cactus IPA-Sertânia. Treatments were allocated in a randomized complete block design in a split-split-plot scheme, with four replications. Main …

Elephants Mitigate The Effects Of Cattle On Wildlife And Other Ecosystem Traits: Experimental Evidence, Truman P. Young, Duncan N. Kimuyu, Kari E. Veblen, Corinna Riginos, Judith Sitters, Lauren Porensky, Wilfred O. Odadi

IGC Proceedings (1977-2023)

On rangelands worldwide, cattle interact with many ecosystem components, most obviously with soils, plants, and other large herbivores. Since 1995, we have been manipulating the presence of cattle, mesoherbivores, and megaherbivores (elephants and giraffes) in a series of eighteen 4-ha (10-acre) plots at the Kenya Long-term Exclosure Experiment. We have demonstrated a wide array of cattle effects on this savanna rangeland, including their reduction of grass cover, wildlife use, and soil nitrogen and phosphorus pools, but their increase of primary productivity and termite abundance. Strikingly, we demonstrate that the presence of mega-herbivores (elephants, mainly) reduces the sizes of these cattle. …

Medical School Watercooler Newsletter - February 3, 2022, Lindsey Lyle

Watercooler Newsletter

This is the February 3, 2022 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• Solidarity Week to highlight compassionate care
• Graduate students awarded Dean’s Predoctoral Fellowships
• Meet a Med Student: Baylee Edwards
• More than 200 items collected for women’s health donation drive
• Alumni couples: Keep sending your stories

Subomiembed: Self-Supervised Representation Learning Of Multi-Omics Data For Cancer Type Classification, Sayed Hashim, Muhammad Ali, Karthik Nandakumar, Mohammad Yaqub

Computer Vision Faculty Publications

For personalized medicines, very crucial intrinsic information is present in high dimensional omics data which is difficult to capture due to the large number of molecular features and small number of available samples. Different types of omics data show various aspects of samples. Integration and analysis of multi-omics data give us a broad view of tumours, which can improve clinical decision making. Omics data, mainly DNA methylation and gene expression profiles are usually high dimensional data with a lot of molecular features. In recent years, variational autoencoders (VAE) [13] have been extensively used in embedding image and text data into …