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Caregivers Need Care, Too: Conceptualising Spiritual Care For Migrant Caregivers-Transnational Mothers, Ma. Adeinev M. Reyes-Espiritu

Theology Department Faculty Publications

Growing research revolving around the plight of (Philippine) migrant domestic workers is noteworthy. However, the focus is largely on their role, capacity and identity as caregivers, meaning as labour migrants and transnational mothers engaged in both paid and unpaid care work. Building on the “care circulation” framework of Baldassar and Merla that conceptualises care as given and received in varying degrees by all family members across time and distance, this paper takes up the task of recognising migrant domestic workers as care receivers. In a particular way, this paper conceptualises care for migrant caregivers-transnational mothers that is based on a …

Integrating Natural Language Processing And Interpretive Thematic Analyses To Gain Human-Centered Design Insights On Hiv Mobile Health: Proof-Of-Concept Analysis, Simone J. Skeen, Stephen Scott Jones, Carolyn Marie Cruse, Keith J. Horvath

Publications and Research

Background: HIV mobile health (mHealth) interventions often incorporate interactive peer-to-peer features. The user-generated content (UGC) created by these features can offer valuable design insights by revealing what topics and life events are most salient for participants, which can serve as targets for subsequent interventions. However, unstructured, textual UGC can be difficult to analyze. Interpretive thematic analyses can preserve rich narratives and latent themes but are labor-intensive and therefore scale poorly. Natural language processing (NLP) methods scale more readily but often produce only coarse descriptive results. Recent calls to advance the field have emphasized the untapped potential of combined NLP …

Foreword, Doriane Lambelet Coleman, Kimberly D. Krawiec

Law and Contemporary Problems

No abstract provided.

The Importance Of Referring To Human Sex In Language, Kathleen Stock

Law and Contemporary Problems

No abstract provided.

A Current Model Of Sex Including All Biological Components Of Sexual Reproduction, Joshua D. Safer

Law and Contemporary Problems

No abstract provided.

Unlawful Genders, Anthony Michael Kreis

Law and Contemporary Problems

No abstract provided.

Stall Wars: Sex And Civil Rights In The Public Bathroom, Wickliffe Shreve

Law and Contemporary Problems

No abstract provided.

Feminism, Trans Justice, And Speech Rights: A Comparative Perspective, Madeleine Pape

Law and Contemporary Problems

No abstract provided.

Hearing And Vestibular Loss With Misuse Of Opioids And Illicit Drugs: A Review Of The Literature, Michelle L. Hughes, Amanda Rodriquez, Jonathan Hatch, Kenneth Zoucha

Department of Special Education and Communication Disorders: Faculty Publications

Background: The purpose of this review was to summarize the literature regarding the effects of opioids and illicit drugs on the auditory and vestibular systems.

Methods: Data were sourced from published papers reporting hearing loss (HL) and/or vestibular loss (VL) following misuse or overdose of opioids or illicit drugs. Most papers consisted of retrospective single-case reports, with few retrospective reviews or prospective cohort studies. Search terms included variations of HL, VL, opioids, and illicit drugs. Search results yielded 51 articles published between 1976 and 2021. A total of 44 articles were reviewed after excluding studies that were not available in …

Absence Of An Association Between Macular Degeneration And Young-Onset Dementia, Tung-Mei Tammy Kuang, Sudha Xirasagar Mbbs., Ph.D., Wei-Yun Lee, Yen-Fu Cheng, Nai-Wen Kuo, Herng-Ching Lin

Faculty Publications

A few population-based studies have reported an association between prior age-related macular degeneration and senile dementia. No study has explored a possible link between prior macular degeneration and young-onset dementia (YOD). This case–control study aimed to evaluate the association of YOD with prior macular degeneration diagnosed in the 5-year period before their index date. Data for this retrospective observational study were retrieved from Taiwan’s National Health Insurance (NHI) dataset. A total of 36,577 patients with newly diagnosed YOD from January 2010 to December 2017 were identified as the study cohort, assigning their diagnosis date as their index date. Comparison patients …

Humpty Dumpty Derangement Syndrome, Jethro K. Lieberman

Other Publications

No abstract provided.

Feasibility Of Administering Human Pancreatic Cancer Chemotherapy In A Spontaneous Pancreatic Cancer Mouse Model, Abagail M Delahoussaye, Joseph Abi Jaoude, Morgan Green, Tara N Fujimoto, Jessica Molkentine, Carolina J Garcia Garcia, Jason P Gay, Ningping Feng, Joseph Marszalek, Natalie Fowlkes, Cullen M Taniguchi

Faculty, Staff and Student Publications

Background: Both modified FOLFIRINOX (mFFX) and gemcitabine/nab-paclitaxel chemotherapy regimens have been shown to improve clinical outcomes in patients with pancreatic cancer, and are often used interchangeably as the standard of care. Preclinical studies often do not use these regimens, since administering these multiagent approaches can be difficult. In this study, we assessed the feasibility of administering these two chemotherapy regimens in spontaneous pancreatic tumors using KPC mice with the ultimate goal of advancing preclinical studies.

Methods: KPC mice were created by breeding KrasLSL-G12D/+ to Trp53fl/fl;Ptf1αCre/+, resulting in KrasLSL-G12D/+;p53fl/+;Ptf1αCre/+ mice. At 14 weeks of age, mice were palpated for spontaneous tumor …

Cardiac Outcomes Of Subjects On Adjuvant Trastuzumab Emtansine Vs Paclitaxel In Combination With Trastuzumab For Stage I Her2-Positive Breast Cancer (Atempt) Study (Tbcrc033): A Randomized Controlled Trial, Romualdo Barroso-Sousa, Ron Bose, Et Al

Open Access Publications

No abstract provided.

The Asexual Male Experience: A Phenomenological Inquiry, Donna M. Mandigo, Louis F. Kavar

The Qualitative Report

This article offers a phenomenological investigation into the experience of asexuality for self-identified asexual, cisgender men. No other study has been previously conducted on this phenomenon; the present study sought to provide new knowledge surrounding the experience of male asexuality and to illuminate any potential differences in the asexual experience between asexual men and asexual women for further conversation. A qualitative analysis of data derived from 8 asexual adult men between 30 and 65 years of age via semi-structured interviews provided detail-rich insight into the inner processes, thoughts, emotions, and behaviors of asexual men. Five major themes arose to comprise …

Spatial Transcriptomics Of Dorsal Root Ganglia Identifies Molecular Signatures Of Human Nociceptors, Diana Tavares-Ferreira, Stephanie Shiers, Pradipta R Ray, Andi Wangzhou, Vivekanand Jeevakumar, Ishwarya Sankaranarayanan, Anna M Cervantes, Jeffrey C Reese, Alexander Chamessian, Bryan A Copits, Patrick M Dougherty, Robert W Gereau, Michael D Burton, Gregory Dussor, Theodore J Price

Faculty, Staff and Student Publications

Nociceptors are specialized sensory neurons that detect damaging or potentially damaging stimuli and are found in the dorsal root ganglia (DRG) and trigeminal ganglia. These neurons are critical for the generation of neuronal signals that ultimately create the perception of pain. Nociceptors are also primary targets for treating acute and chronic pain. Single-cell transcriptomics on mouse nociceptors has transformed our understanding of pain mechanisms. We sought to generate equivalent information for human nociceptors with the goal of identifying transcriptomic signatures of nociceptors, identifying species differences and potential drug targets. We used spatial transcriptomics to molecularly characterize transcriptomes of single DRG …

Evidence For Human Placental Slc6a4 Dysregulation In Prenatal Opioid And Alcohol Exposure, Sharon Ruyak, Shahani Noor, Melody Sun, Annette Fernandez Oropeza, Jared Didomenico, Dominique Rodriquez, Lidia Enriquez Marquez, Ludmila Bakhireva, Erin Milligan

Sigma Foundation for Nursing Research Grant Reports

The purpose of this project was to address the convergent effect of POE and PAE on key placental immune and serotonin factors. The central hypothesis was that increased opioid-induced activation of the TLR4 pathway in the placenta results in dysregulated immune cytokine expression and serotonin function and this relationship will be magnified in POE and PAE placental tissue.

A Synergistic Combination Of Dha, Luteolin, And Urolithin A Against Alzheimer’S Disease, Dona P.W. Jayatunga, Eugene Hone, Binosha W.M.A. Fernando, Manohar L. Garg, Giuseppe Verdile, Ralph N. Martins

Research outputs 2022 to 2026

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder and the most common form of dementia worldwide. The classical AD brain is characterized by extracellular deposition of amyloid-β (Aβ) protein aggregates as senile plaques and intracellular neurofibrillary tangles (NFTs), composed of hyper-phosphorylated forms of the microtubule-associated protein Tau. There has been limited success in clinical trials for some proposed therapies for AD, so attention has been drawn toward using alternative approaches, including prevention strategies. As a result, nutraceuticals have become attractive compounds for their potential neuroprotective capabilities. The objective of the present study was to derive a synergistic nutraceutical combination in …

Solving Resource Allocation Model By Using Dynamic Optimization Technique For Al-Raji Group Companies For Soft Drinks And Juices, Mohammed Hasan, Mohammed Sadiq Al-Doori

Journal of Economics and Administrative Sciences

In this paper, the problem of resource allocation at Al-Raji Company for soft drinks and juices was studied. The company produces several types of tasks to produce juices and soft drinks, which need machines to accomplish these tasks, as it has 6 machines that want to allocate to 4 different tasks to accomplish these tasks. The machines assigned to each task are subject to failure, as these machines are repaired to participate again in the production process. From past records of the company, the probability of failure machines at each task was calculated depending on company data information. Also, the …

Pharmacological Modulation Of Kv13 Potassium Channel Selectively Triggers Pathological B Lymphocyte Apoptosis In Vivo In A Genetic Cll Model, Filippo Severin, Andrea Urbani, Tatiana Varanita, Magdalena Bachmann, Michele Azzolini, Veronica Martini, Marco Pizzi, Angelo Paolo Dei Tos, Federica Frezzato, Andrea Mattarei, Paolo Ghia, Maria Teresa Sabrina Bertilaccio, Erich Gulbins, Cristina Paradisi, Mario Zoratti, Gianpietro Carlo Semenzato, Luigi Leanza, Livio Trentin, Ildiko Szabò

Faculty, Staff and Student Publications

Background: Ion channels are emerging as promising oncological targets. The potassium channels Kv1.3 and IKCa are highly expressed in the plasma membrane and mitochondria of human chronic lymphocytic leukemia (CLL) cells, compared to healthy lymphocytes. In vitro, inhibition of mitoKv1.3 by PAPTP was shown to kill ex vivo primary human CLL cells, while targeting IKCa with TRAM-34 decreased CLL cell proliferation.

Methods: Here we evaluated the effect of the above drugs in CLL cells from ibrutinib-resistant patients and in combination with Venetoclax, two drugs used in the clinical practice. The effects of the drugs were tested also in the Eμ-TCL1 …

Adverse Events Reporting Of Clinical Trials In Exercise Oncology Research (Advance): Protocol For A Scoping Review, Hao Luo, Oliver Schumacher, Daniel A. Galvão, Robert U. Newton, Dennis R. Taaffe

Research outputs 2022 to 2026

Introduction: Adequate, transparent, and consistent reporting of adverse events (AEs) in exercise oncology trials is critical to assess the safety of exercise interventions for people following a cancer diagnosis. However, there is little understanding of how AEs are reported in exercise oncology trials. Thus, we propose to conduct a scoping review to summarise and evaluate current practice of reporting of AEs in published exercise oncology trials with further exploration of factors associated with inadequate reporting of AEs. The study findings will serve to inform the need for future research on standardisation of the definition, collection, and reporting of AEs for …

A Review Of Coronaviruses Associated With Kawasaki Disease: Possible Implications For Pathogenesis Of The Multisystem Inflammatory Syndrome Associated With Covid-19, Fatima Farrukh Shahbaz, Russell Seth Martins, Abdullah Umair, Ronika Devi Ukrani, Kauser Jabeen, M Rizwan Sohail, Erum Khan

Medical College Documents

Multisystem Inflammatory Syndrome in Children (MIS-C), representing a new entity in the spectrum of manifestations of COVID-19, bears symptomatic resemblance with Kawasaki Disease (KD). This review explores the possible associations between KD and the human coronaviruses and discusses the pathophysiological similarities between KD and MIS-C and proposes implications for the pathogenesis of MIS-C in COVID-19. Since 2005, when a case-control study demonstrated the association of a strain of human coronavirus with KD, several studies have provided evidence regarding the association of different strains of the human coronaviruses with KD. Thus, the emergence of the KD-like disease MIS-C in COVID-19 may …

Antibody Attributes That Predict The Neutralization And Effector Function Of Polyclonal Responses To Sars-Cov-2, Harini Natarajan, Shiwei Xu, Andrew R. Crowley, Savannah E. Butler, Joshua A. Weiner, Evan M. Bloch, Kirsten Littlefield, Sarah E. Benner, Ruchee Shrestha, Olivia Ajayi, Wendy Wieland-Alter, David Sullivan, Shmuel Shoham, Thomas C. Quinn, Arturo Casadevall, Andrew Pekosz, Andrew D. Redd, Aaron A.R. Tobian, Ruth I. Connor, Peter F. Wright, Margaret E. Ackerman

Dartmouth Scholarship

BACKGROUND: While antibodies can provide significant protection from SARS-CoV-2 infection and disease sequelae, the specific attributes of the humoral response that contribute to immunity are incompletely defined. METHODS: We employ machine learning to relate characteristics of the polyclonal antibody response raised by natural infection to diverse antibody effector functions and neutralization potency with the goal of generating both accurate predictions of each activity based on antibody response profiles as well as insights into antibody mechanisms of action. RESULTS: To this end, antibody-mediated phagocytosis, cytotoxicity, complement deposition, and neutralization were accurately predicted from biophysical antibody profiles in both discovery and validation …

Evaluation Of Herbage Intake Estimation Methods For Dairy Cattle Grazing On Semi-Extensive Pastures, S. Perdana-Decker, E. Velasco, J. Werner, U. Dickhoefer

IGC Proceedings (1977-2023)

Available empirical and mechanistic models to estimate total dry matter intake (DMI) and pasture dry matter intake (PDMI) of grazing lactating dairy cows have mainly been developed under intensive grazing conditions. The objective was to evaluate the adequacy of such existent models for use under semi-extensive grazing conditions, characterised by semi-natural grassland and less intensive resource use. Feed intake of lactating cows was measured on three commercial organic dairy farms in South Germany during one or two 6-d-periods/farm in 2019. Each period, DMI was determined in 10 or 20 cows per farm from their daily faecal output measured using titanium …

Tracing The Path Of Technology Diffusion: The Case Of Nturumenti, Narok, Kenya, Paul N. Katiku, R. Kimitei, S. Amboga, G. A. Keya, B. Korir, J. Nginyi

IGC Proceedings (1977-2023)

An array of technologies; growing improved wheat varieties, bulking and collective marketing of wheat grains, sheep breed improvement, ram sharing, feedlot sheep fattening for market, strategic sheep deworming, pasture establishment and conservation practices; were introduced to members of a community based organization (CBO) in Nturumenti, anti-female genital mutilation and anti-poverty organization (AFAPO) in 2014. The CBO members, composed of youthful 19 men and 7 females, were intensively exposed and involved in the new skills both theoretically and practically in the farmers’ field school model. Even though the 8 farming technology options were suitable for the study environment, their adoption and …

The Use Of Sunn Hemp As Forage In Florida, João M. B. Vendramini, J. E. Garzon Alfonso, H. M. Da Silva, Maria L. Silveira, J. C. B. Dubeux Jr., M. Kaneko

IGC Proceedings (1977-2023)

Sunn hemp (Crotalaria juncea L.) is a warm-season annual legume that has been widely used as cover crop; however, there is potential to use sunn hemp as forage in subtropical regions. The objective of this study was to evaluate management practices to improve the efficiency of using sunn hemp as a forage crop. The study was conducted in Ona, Florida, USA from 2016 to 2018 and tested the factorial arrangement of five sunn hemp genotypes (Crescent Sunn, Ubon, Blue Leaf, and AU Golden) and two harvest times (60 d after seeding or flowering) with four replicates. There was a …

The Optimum Seeding And Harvesting Dates Of Sorghum-Sudangrass Hybrid (Sorghum Bicolor L.) Via Optimum Moving Response Surface Methodology, M. Kim, J. Y. Kim, M. H. Jo, C. H. Kim, K. Sung

IGC Proceedings (1977-2023)

This study aimed to detect the optimum seeding and harvesting dates, and to verify the variation of dry matter yield (DMY) for sorghum-sudangrass hybrid (SSH) via optimum moving RSM proposed to optimize the RSM in metadata. For detecting the optimum point, a response surface methodology (RSM) has been known well in agricultural science. The SSH metadata (n = 856) consists of individual experiments that could be performed to check the optimum seeding and harvesting dates by classic RSM. However, the SSH metadata failed to produce an effective single equation which can be detected the optimum seeding and harvesting dates due …

The Importance Of Soil Seed Bank Dynamics As Potential Indicators Of Desertification Tipping Point, N. Hamunyela, W. C. Nesongano, K. Tielbörger

IGC Proceedings (1977-2023)

Soil seed banks play a major role in the vegetation dynamics of drylands, where annual rainfall is unpredictable and plants depend on a persistent stage (seeds) to survive over the dry season. The purpose of the study is to understand the behaviour of the rangeland system in terms of soil seed bank dynamics before, during and after crossing the “so called” DTP and to determine whether different management systems plays a role in accelerating the desertification process. Through the use of the Space for Time Substitution Approach the study analysed spatial grazing gradients (gradients radiating from water points) to predict …

The Influence Of Legume Species On The Productivity And Quality Of Multi-Species Swards In Four Production Years, A. Adamovics, I. Gutmane

IGC Proceedings (1977-2023)

In Latvia’s farms, the use of multicomponent grass–legume mixtures is a traditional practice, because swards can secure good persistence and stable productivity. Red clover Trifolium pratense (Tp) and lucerne Medicago sativa (Ms) are traditional forage crops, but fodder galega Galega orientalis (Go) is grown for a relatively short period. Field trials were carried out with the aim to investigate forage yield and quality during four production years of sown legume–grass swards. Mixtures were composed of 50% legumes and 50% grasses (G). Swards were cut three times during the vegetation season. Significant differences in dry matter (DM) yield were found between …

Solidarity Sing Alongs: Music As A Disruptive Force In The 2011 Protests In Madison, Wisconsin, Clare Mazack

Tapestries: Interwoven voices of local and global identities

Protest music, when created and shared with intention and rooted in a social movement, can act as a force of disruption to systems of power. This paper focuses on the disruptive nature of the Solidarity Sing Alongs during the 2011 protests in my hometown of Madison, Wisconsin, that occurred in response to Governor Walker’s proposed Act 10, which cut funding for education, healthcare, pensions, and childcare, as well as attacked collective bargaining rights and other union abilities. The Solidarity Sing Alongs act as a case study of how music, as a part of the protests, interrupted the political powers that …

What It Means To Be A Monster: The British Raj, Race Science, And "The Other" In Fantasy And Folklore, Adam Majid

Tapestries: Interwoven voices of local and global identities

J.R.R. Tolkien wrote The Fellowship of the Ring, the first entry in the culture-defining Lord of the Rings trilogy, from his cottage on Northmoor Road, nestled comfortably in the sleepy streets of North Oxford: the intellectual heart of the British Empire, during the last decade preceding the nation’s imperial decline. British rule over an entire quarter of the planet maintained itself not by force alone, but by the imposition of the ideology of white supremacy on commonwealth citizens, first implemented through Christian thought and later through the “scientific” study of race in the 19th and 20th centuries. While being a …