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The Rattler (Volume 110, Issue 5), St. Mary's University

The Rattler (Previous issues)

Founded in 1919, The Rattler is the student voice of St. Mary’s University in San Antonio, Texas. The newspaper documents campus life, academic and social issues, student opinion, and local and national events as they relate to the University community. Content typically includes news articles, editorial commentary, arts and culture coverage, sports reporting, and advertisements.

Ms 068 Guide To Carl F. Tessmer, Md Papers (1945-1995), Carl F. Tessmer (1912-2012)

Manuscript Finding Aids

Dr. Tessmer served as the first Director of the Atomic Bomb Casualty Commission (ABCC), NAS-NRC Field Agency, from 1948 to 1951. His archival collection relates to the origin and subsequent progress of the ABCC. The bulk of the material in his collection is administrative in nature. Included are semi-annual and annual reports, NAS and NRC committee reports, early negotiations, reports from the initial clinical surveys, published scientific reports and correspondence dating from 1947. Approximately, 300 photographs and 15 sets of negatives accompanied Dr. Tessmer's Collection. See more at MS 068.

The Law Of Scale Independence, Jonathan D. Phillips

Geography Faculty Publications

Geography and geosciences deal with phenomena that span spatial scales from the molecular to the planetary, and temporal scales from instantaneous to billions of years. A strong reductionist tradition in geosciences and spatial sciences tempts us to seek to apply similar representations and process-based explanations across these vast-scale ranges, usually from a bottom-up perspective. However, the law of scale independence (LSI) states that for any phenomenon that exists across a sufficiently large range of scales, there exists a scale separation distance at which the scales are independent with respect to system dynamics and explanation. The LSI is evaluated here from …

Role Of Specialized Pro-Resolving Mediators In Reducing Neuroinflammation In Neurodegenerative Disorders, Jana Ponce, Arzu Ulu, Corrine Hanson, Erin Cameron-Smith, Jenna Wuebker, John Bertoni, Alfred Fisher, Ka-Chun Siu, Vivien Marmelat, Jiri Adamec, Danish Bhatti

Department of Biochemistry: Faculty Publications

Alzheimer’s disease (AD) and Parkinson’s disease (PD) are neurodegenerative disorders that affect millions of individuals worldwide. As incidence of these conditions increases with age, there will undoubtedly be an increased prevalence of cases in the near future. Neuroinflammation is a hallmark in the development and progression of neurodegenerative diseases and prevention or resolution of chronic neuroinflammation may represent a novel approach to treatment. The present review highlights the potential of the anti-inflammatory and pro-resolving effects of polyunsaturated fatty acid (PUFA)- derived mediators (Specialized Pro-resolving Mediators—SPM) in neurodegenerative disorders. PUFA-derived SPM are biosynthesized in response to chemicals produced from acute inflammatory …

The Comment, February 17, 2022, Bridgewater State University

The Comment

No abstract provided.

Covid-19 Breakthroughs, Personalized Medicine At Scale And Thousands Of Quality Jobs In Birmingham: Southern Research Prepares For Its Next 80 Years, Staff

Browse All News

No abstract provided.

State Of Industry 5.0—Analysis And Identification Of Current Research Trends, Aditya Akundi, Daniel Euresti, Sergio Luna, Wilma Ankobiah, Amit Lopes, Immanuel Edinbarough

Manufacturing & Industrial Engineering Faculty Publications

The term Industry 4.0, coined to be the fourth industrial revolution, refers to a higher level of automation for operational productivity and efficiency by connecting virtual and physical worlds in an industry. With Industry 4.0 being unable to address and meet increased drive of personalization, the term Industry 5.0 was coined for addressing personalized manufacturing and empowering humans in manufacturing processes. The onset of the term Industry 5.0 is observed to have various views of how it is defined and what constitutes the reconciliation between humans and machines. This serves as the motivation of this paper in identifying and analyzing …

Robert Brandt Interview For The Boonshoft School Of Medicine 50th Anniversary Oral History Project, Robert Brandt, Kristen Dilger

Boonshoft 50th Anniversary Oral History Project

Kristen Dilger interviews Robert Brandt, a graduate of the Boonshoft School of Medicine. He worked in Family Medicine as both a primary care physical and HIV/AIDS specialist, along with his role as a clinical professor for the Boonshoft School of Medicine until his retirement in 2018. Part of the class of 1980, Brandt discusses his collegiate career, including why he chose Wright State University's new medical college and talks about what it was like attending the college. He talks about the challenges and processes of attending a new medical college, and how attending the Wright State University Boonshoft School of …

Gc Minutes Feb 17, 2022, Graduate Council

Graduate Council Minutes

No abstract provided.

Investigating How Ecologically Relevant Thermal Conditions Affect Gonadal Development In A Turtle With Temperature-Dependent Sex Determination, Anthony Trey Breitenbach

Theses and Dissertations

In turtles and numerous other reptilian species, sex is determined by the environmental temperatures during embryonic development, which is referred to temperature-dependent sex determination (TSD). In the type of TSD common in turtles, cool temperatures (below 29 °C) during embryonic development produce mainly males while warm temperatures (above 29 °C) produce mainly females. Gonadal differentiation in TSD species involves numerous genes that are also necessary to produce a testis or ovary in species with genotypic sex determination. However, most of what we know about TSD comes from studies performed in the laboratory using constant temperature incubation conditions, which are not …

Whalesong 2022-02-17 (V.42 No.1), Mike Flunker, Kenedy Williams, Lucas Stewart, Sierra Lissick, Jon Calleja, Jennifer Ward, Jessica Whitney, Carrie Kline, Amanda Gorman

Whalesong

No abstract provided.

Whalesong 2022-02-17, N/A N/A

Whalesong

No abstract provided.

Microbial Feedbacks On Soil Organic Matter Dynamics Underlying The Legacy Effect Of Diversified Cropping Systems, Maria Mooshammer, A. Stuart Grandy, Francisco Calderon, Steve Culman, Bill Deen, Rhae A. Drijber, Kari Dunfield, Virginia L. Jin, R. Michael Lehman, Shannon L. Osborne, Marty Schmer, Timothy M. Bowles

Faculty Publications

Crop rotations have well-known aboveground and belowground benefits. At regional to continental scales, the unifying mechanisms of how diversified rotations alter soil organic matter (SOM) dynamics have not been demonstrated. We assessed how increasing crop rotational diversity across a soil-climate gradient affected the integrated response of SOM chemistry, microbial community composition, and its enzymatic potential to degrade SOM. Agroecosystems with the same crop rotational diversity (all sampled during the corn phase) shared similarities in molecular SOM patterns with a strong microbial signature, pointing to common transformation processes. Differences in SOM chemistry between rotations were mainly characterized by shifts in microbial …

Late-Stage Chemoenzymatic Installation Of Hydroxy-Bearing Allyl Moiety On The Indole Ring Of Tryptophan-Containing Peptides, Nagaraju Mupparapu, Lauren Brewster, Katrina F. Ostrom, Sherif I. Elshahawi

Pharmacy Faculty Articles and Research

The late-stage functionalization of indole- and tryptophan-containing compounds with reactive moieties facilitates downstream diversification and leads to changes in their biological properties. Here, the synthesis of two hydroxy-bearing allyl pyrophosphates is described. A chemoenzymatic method is demonstrated which uses a promiscuous indole prenyltransferase enzyme to install a dual reactive hydroxy-bearing allyl moiety directly on the indole ring of tryptophan-containing peptides. This is the first report of late-stage indole modifications with this reactive group.

The Colby Echo (2022-02-17), Colby College

The Colby Echo

Published by the students of Colby College since 1877, The Colby Echo is the weekly, editorially independent student-run newspaper of Colby College in Waterville, Maine. Published monthly, 1877-1886; semi-monthly; 1886-1897; and weekly during the academic year, 1898-present.

Chemical Reversible Crosslinking Enables Measurement Of Rna 3d Distances And Alternative Conformations In Cells, Ryan Van Damme, Kongpan Li, Minjie Zhang, Jianhui Bai, Wilson H. Lee, Joseph D. Yesselman, Zhipeng Lu, Willem A. Velema

Department of Chemistry: Faculty Publications

Three-dimensional (3D) structures dictate the functions of RNA molecules in a wide variety of biological processes. However, direct determination of RNA 3D structures in vivo is difficult due to their large sizes, conformational heterogeneity, and dynamics. Here we present a method, Spatial 2′-Hydroxyl Acylation Reversible Crosslinking (SHARC), which uses chemical crosslinkers of defined lengths to measure distances between nucleotides in cellular RNA. Integrating crosslinking, exonuclease (exo) trimming, proximity ligation, and high throughput sequencing, SHARC enables transcriptome-wide tertiary structure contact maps at high accuracy and precision, revealing heterogeneous RNA structures and interactions. SHARC data provide constraints that improves Rosetta-based RNA 3D …

Improving Taxonomic Delimitation Of Fungal Species In The Age Of Genomics And Phenomics, Asjley Stengel, Kimberly M. Stanke, Amanda C. Quattrone, Joshua Herr

Department of Plant Pathology: Faculty Publications

Species concepts have long provided a source of debate among biologists. These lively debates have been important for reaching consensus on how to communicate across scientific disciplines and for advancing innovative strategies to study evolution, population biology, ecology, natural history, and disease epidemiology. Species concepts are also important for evaluating variability and diversity among communities, understanding biogeographical distributions, and identifying causal agents of disease across animal and plant hosts. While there have been many attempts to address the concept of species in the fungi, there are several concepts that have made taxonomic delimitation especially challenging. In this review we discuss …

Aapm Medical Physics Practice Guideline 12.A: Fluoroscopy Dose Management, Ryan F. Fisher, Kimberly E. Applegate, Lindsey K. Berkowitz, Olav Christianson, Jaydev K. Dave, Lindsay Deweese, Nichole Harris, Mary Ellen Jafari, A. Kyle Jones, Robert J. Kobistek, Brendan Loughran, Loren Marous, Donald L. Miller, Beth Schueler, Bryan C. Schwarz, Adam Springer, Kevin A. Wunderle

Radiology Faculty Publications

No abstract provided.

The Antarctic Weddell Seal Genome Reveals Evidence Of Selection On Cardiovascular Phenotype And Lipid Handling, Hyun Ji Noh, Jason Turner-Maier, S. Anne Schulberg, Michael L. Fitzgerald, Jeremy Johnson, Kaitlin N. Allen, Luis A. Huckstadt, Annabelle J. Batten, Jessica Alfoldi, Daniel P. Costa, Elinor K. Karlsson, Warren M. Zapol, Emmanuel S. Buys, Kerstin Lindbald-Toh, Allyson G. Hindle

Life Sciences Faculty Research

The Weddell seal (Leptonychotes weddellii) thrives in its extreme Antarctic environment. We generated the Weddell seal genome assembly and a high-quality annotation to investigate genome-wide evolutionary pressures that underlie its phenotype and to study genes implicated in hypoxia tolerance and a lipid-based metabolism. Genome-wide analyses included gene family expansion/contraction, positive selection, and diverged sequence (acceleration) compared to other placental mammals, identifying selection in coding and non-coding sequence in five pathways that may shape cardiovascular phenotype. Lipid metabolism as well as hypoxia genes contained more accelerated regions in the Weddell seal compared to genomic background. Top-significant genes were SUMO2 and EP300; …

The Association Of Persistent Symptoms Of Depression And Anxiety With Recurrent Acute Coronary Syndrome Events: A Prospective Observational Study, Abdullah S. Alhurani, Ayman M. Hamdan-Mansour, Muayyad M. Ahmad, Gabrielle Mckee, Sharon O’Donnell, Frances O’Brien, Mary Mooney, Zyad T. Saleh, Debra K. Moser

Nursing Faculty Publications

The purpose of this study was to examine the role of persistent symptoms of depression and anxiety in a second acute coronary syndrome (ACS) event. Data presented in this study were from an RCT study. A follow-up for 24 months after baseline to detect a second ACS event among 1162 patients from five hospitals. Hierarchal Cox regression analyses were used. The results showed that persistent depression only (HR 2.27; 95% CI: 1.35–3.81; p = 0.002), and comorbid persistent depression and anxiety (HR 2.03; 95% CI: 1.03–3.98; p = 0.040) were the significant predictors of a second ACS event. Secondary education …

Nanoscale Rules Governing The Organization Of Glutamate Receptors In Spine Synapses Are Subunit Specific, Martin Hruska, Rachel E Cain, Matthew B Dalva

Department of Neuroscience Faculty Papers

Heterotetrameric glutamate receptors are essential for the development, function, and plasticity of spine synapses but how they are organized to achieve this is not known. Here we show that the nanoscale organization of glutamate receptors containing specific subunits define distinct subsynaptic features. Glutamate receptors containing GluA2 or GluN1 subunits establish nanomodular elements precisely positioned relative to Synaptotagmin-1 positive presynaptic release sites that scale with spine size. Glutamate receptors containing GluA1 or GluN2B specify features that exhibit flexibility: GluA1-subunit containing AMPARs are found in larger spines, while GluN2B-subunit containing NMDARs are enriched in the smallest spines with neither following a strict …

Sustained Efficacy And Safety Of Burosumab, A Monoclonal Antibody To Fgf23, In Children With X-Linked Hypophosphatemia, Agnès Linglart, Erik A Imel, Michael P Whyte, Anthony A Portale, Wolfgang Högler, Annemieke M Boot, Raja Padidela, William Van't Hoff, Gary S Gottesman, Angel Chen, Alison Skrinar, Mary Scott Roberts, Thomas O Carpenter

2020-Current year OA Pubs

PURPOSE: In X-linked hypophosphatemia (XLH), excess fibroblast growth factor-23 causes hypophosphatemia and low calcitriol, leading to musculoskeletal disease with clinical consequences. XLH treatment options include conventional oral phosphate with active vitamin D, or monotherapy with burosumab, a monoclonal antibody approved to treat children and adults with XLH. We have previously reported outcomes up to 64 weeks, and here we report safety and efficacy follow-up results up to 160 weeks from an open-label, multicenter, randomized, dose-finding trial of burosumab for 5- to 12-year-old children with XLH.

METHODS: After 1 week of conventional therapy washout, patients were randomized 1:1 to burosumab every …

Draft Genome Sequencing Of Three Glutaraldehyde-Tolerant Bacteria From Produced Water From Hydraulic Fracturing, Stephen Techtmann, Andrew L. Baldwin, Dotun Aluko, Justin Andersen, Cole Becker, Grace Chandler, Steve Forgrave, Madelyn Jones, Ina Klasner, Jared Martini, Noah Mason, Ryleigh Parsons, Nick Peterson, Erik Reynolds, Lydia Schroeder

Michigan Tech Publications, Part 1

Here, we report the draft genome sequence of three glutaraldehyde-resistant isolates from produced water from hydraulic fracturing operations. The three strains were identified as sp. strain G11, sp. strain G15, and sp. strain G16. The genome sequences of these isolates will provide insights into biocide resistance in hydraulic fracturing operations.

2022-02-17 Faculty Senate Newsletter, Morehead State University. Faculty Senate.

Faculty Senate Records

Faculty Senate newsletter from February 17, 2022.

Novel Role Of Ghrelin Receptor In Gut Dysbiosis And Experimental Colitis In Aging, Ji Yeon Noh, Chia-Shan Wu, Jennifer A A Deluca, Sridevi Devaraj, Arul Jayaraman, Robert C Alaniz, Xiao-Di Tan, Clinton D Allred, Yuxiang Sun

Faculty, Staff and Students Publications

Chronic low-grade inflammation is a hallmark of aging, which is now coined as inflamm-aging. Inflamm-aging contributes to many age-associated diseases such as obesity, type 2 diabetes, cardiovascular disease, and inflammatory bowel disease (IBD). We have shown that gut hormone ghrelin, via its receptor growth hormone secretagogue receptor (GHS-R), regulates energy metabolism and inflammation in aging. Emerging evidence suggests that gut microbiome has a critical role in intestinal immunity of the host. To determine whether microbiome is an integral driving force of GHS-R mediated immune-metabolic homeostasis in aging, we assessed the gut microbiome profiles of young and old GHS-R global knockout …

Repair-Assisted Damage Detection Reveals Biological Disparities In Prostate Cancer Between African Americans And European Americans, Kimiko L Krieger, Jie H Gohlke, Kevin J Lee, Danthasinghe Waduge Badrajee Piyarathna, Patricia D Castro, Jeffrey A Jones, Michael M Ittmann, Natalie R Gassman, Arun Sreekumar

Faculty, Staff and Students Publications

African Americans (AA) are two times more likely to be diagnosed with and succumb to prostate cancer (PCa) compared to European Americans (EA). There is mounting evidence that biological differences in these tumors contribute to disparities in patient outcomes. Our goal was to examine the differences in DNA damage in AA and EA prostate tissues. Tissue microarrays with matched tumor-benign adjacent pairs from 77 AA and EA PCa patients were analyzed for abasic sites, oxidative lesions, crosslinks, and uracil content using the Repair Assisted Damage Detection (RADD) assay. Our analysis revealed that AA PCa, overall, have more DNA damage than …

An Axiomatic And Contextual Review Of The Armitage And Doll Model Of Carcinogenesis, W. Zane Billings, Justin Clifton, Josh Hiller, Tommy Meek, Andrew Penland, Wesley Rogers, Gabriella Smokovich, Andrew Velasquez-Berroteran, Eleni Zamagias

Spora: A Journal of Biomathematics

In 1954, Armitage and Doll published one of the most influential papers in the history of mathematical epidemiology. However, when one examines the literature one finds that there are in fact at least three distinct mathematical models attributed to the 1954 paper. In this study, we examine this important paper and the mathematical derivation of their model. We find, very surprisingly, that no stochastic process can account for all the assumptions of the model and that many of the models in the literature use a consistent subset of the assumptions used in Armitage and Doll's paper.

Interview With George Rogers, Zach S. Henderson Library Special Collections

Zach S. Henderson Library Special Collections Oral History Collection

George Rogers interviewed by an unknown interviewer possibly affiliated with Georgia Heritage Trust, January 17, 1991. Find this collection in the University Libraries' catalog!

Benefits Of Chinese Qigong Mind-Body Exercise Program On Salivary Biomarkers And Physical Functions In Older Adults, Salmaan Faghihi, Ashley Nguyen, Karen Cruz, Mary Bahwawsi, Joseph Nocito, Zenong Yin, Yan Du, Tianou Zhang

International Journal of Exercise Science: Conference Proceedings

Chinese Qigong mind-body exercise such as Five Animal Frolics have been shown to improve quality of life, physical functions, cognitive functions, and mental health in older adults with various chronic health conditions. However, there is a lack of comprehensive understanding of the biological mechanisms, underlying the health effects after exposing to conventional and mind-body exercise. PURPOSE: The purpose of the study is to profile the changes associated with salivary biomarkers and physical functions after exposure to a 12-week five animal frolics, Chinese Qigong mind-body exercise program in community-dwelling older adults. METHODS: Thirteen community-dwelling adults who attended the Senior …

Males, But Not Females, Demonstrate Mitochondrial Dysfunction In The C26 Model Of Cancer Cachexia, Ricky D. Solis, J. William Deaver, Eleanor R. Schrems, Ana Regina Cabrera, Seongkyun Lim, Francielle Morena Da Silva, Tyrone A. Washington, Nicholas P. Greene, Michael P. Wiggs

International Journal of Exercise Science: Conference Proceedings

Cancer cachexia is characterized by progressive muscle wasting that can lead to symptoms such as anemia, severe weight loss, and fatigue. These symptoms can lead to limitations in activities of daily living and can cause resistance to chemotherapy treatments in cancer patients. There are no current treatments available to treat cancer cachexia and a critical need remains to identify mechanisms of cancer cachexia. Recently, our group identified mitochondrial disfunction precedes muscle atrophy in males but not females in a model of lung cancer induced atrophy. However, it is unknown whether this finding is replicated when studying a different type of …