Digital Commons Network^™

Wittgenstein And Hume On Miracles, Samuel Wheeler

Undergraduate Research Symposium

In this paper, I intend to contrast the positions of Ludwig Wittgenstein and David Hume on miracles. While Hume holds that miracles are violations of laws of nature which can never be probable, Wittgenstein would reject this definition. Instead, he takes a broader stance on miracles and holds that many events which are not transgressions of laws of nature can be seen as miraculous. And the point of this is to highlight the vastly different events we call miracles. Contra Hume, Wittgenstein thinks that even some of our greatest certainties can call up in us a sense of absolute wonder …

Dignity Norfolk: How One Tidewater Group Enabled Gay And Lesbian Catholics To Form Long Lasting Friendships And Chosen Families, Chelsea Lembert

Undergraduate Research Symposium

In the past decade, research has been conducted to look into the history of the Queer Community of the Tidewater Region. Students and community volunteers have conducted interviews and gathered documents connected to the queer community to grow the study and breadth of available information for future researchers. However, more in-depth knowledge of community connections and familial ties within the queer community in the Tidewater Region was needed. Through research into Our Own Newspaper, local historical background information, and in-person interviews, I pieced together first-hand accounts of life through the eyes of a gay man or lesbian woman living in …

Access To Nitrogen Heterocycles Via Borrowing Hydrogen Catalysis, Robert P. Reynolds, Kellen P. Mcguire, Conor T. Mccormick, Kyle M. Lambert

Undergraduate Research Symposium

Nitrogen heterocycles are ubiquitous motifs which occur as the core structure of several alkaloid natural products exhibiting inherent biological activity against an array of bacteria, fungi, viruses, and cancer cell lines. These azacycles serve as key synthetic building blocks for medicinal chemists to access more structurally complex and diverse compounds with tunable biological properties. A synthetic approach to these valuable motifs employing intramolecular borrowing hydrogen catalysis has been developed. The utility of the developed chemistry will be applied to synthetic efforts towards the recently isolated Cylicomorphins A-E.

Oxidation Of Thiols To Disulfides Using An Environmentally “Green” Organocatalyst And New Mechanistic Insights, Kosta V. Vlasakakis, Olivia M. White, Robert P. Reynolds, Shayne M. Weierbach, Shannon M. Weaver, Ramsey T. Ritter, Nishi H. Patel, Eric C. Hayes, Sydney Dunmire, Kyle M. Lambert

Undergraduate Research Symposium

The selective oxidation of thiols to disulfides is an area of great importance in the areas of materials and medicinal chemistry research. The production of polymers, rubber, pharmaceuticals, and the folding of proteins in biological systems all rely on the formation of disulfide bonds. Herein, we introduce a stoichiometric and electrocatalytic method for the oxidation of various pharmaceutically and biologically relevant thiols into their respective disulfides in more environmentally benign solvents such as water and alcohol solvents. The scope of the transformation was evaluated and a detailed mechanistic study involving control experiments, experimental kinetic studies, and computational investigations led to …

Revisiting The History Of Takayasu Disease: Studies And Surgical Treatment, Shavkat I. Karimov, Akmal A. Irnazarov, Abdurasul A. Yulbarisov, Khojiakbar K. Alidjanov

Central Asian Journal of Medicine

Nonspecific aortoarteritis (Takayasu disease) is a systemic disease belonging to the group of vasculitis, mainly affecting the arteries of the elastic and muscular-elastic types of large and medium caliber with localization of the inflammatory process in the media and adventitia. The article describes the history of the development of ideas about clinical manifestations, morphological changes and the course of the disease from 1761 to the present, the chronology of medical achievements in the study of this disease.

Lectins And Their Application In Forensic Medical Practice, Mukharrama A. Khasanova, Nizom J. Ermatov

Central Asian Journal of Medicine

The problem of obtaining economically cheap drugs for determining the group (in liquid form and in traces) is relevant. Diagnostic lectinology in relation to the determination of the blood group of the AB0 system is currently widely used in many countries of the world. The commercial cost of lectins is tens and even hundreds of times lower than the cost of rabbit absorption serum. The study of lectins in the seeds of some plants growing on the territory of Uzbekistan has shown the possibility of using them in the determination of antigens of the AB0 system.

Serving Students With Disabilities Who Are Culturally And Linguistically Diverse In Rural Communities: Technology Access Is Essential, Benjamin Gallegos, Lisa A. Dieker, Rebecca Smith, Nicole C. Ralston

Northwest Journal of Teacher Education

Before the COVID-19 pandemic changed the educational landscape, students with disabilities, especially those who are culturally and linguistically diverse, and their special education teachers who worked and attended schools located in rural communities faced barriers most schools and communities experienced nationwide. As schools shifted to remote virtual learning due to the COVID-19 pandemic, rural schools were already at a disadvantage with the lack of resources with technology access. The call for addressing shortcomings in the various digital technology supports towards enhancing the teachers’ delivery of content and the students’ academic outcomes has been a continual challenge to address. This paper …

Pharmacologic Ascorbic Acid As Early Therapy For Hospitalized Patients With Covid-19: A Randomized Clinical Trial, Dagan Coppock, Pierre-Christian Violet, Gustavo Vasquez, Katherine Belden, Michael Foster, Bret Mullin, Devon Magee, Isabelle Mikell, Lokesh Shah, Victoria Powers, Brian Curcio, Daniel A. Monti, Mark Levine

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Despite the widespread availability of effective vaccines, new cases of infection with severe acute respiratory syndrome coronavirus-2, the cause of coronavirus disease 2019 (COVID-19), remain a concern in the settings of vaccine hesitancy and vaccine breakthrough. In this randomized, controlled, phase 2 trial, we hypothesized that high-dose ascorbic acid delivered intravenously to achieve pharmacologic concentrations may target the high viral phase of COVID-19 and thus improve early clinical outcomes. Sixty-six patients admitted with COVID-19 and requiring supplemental oxygen were randomized to receive either escalating doses of intravenous ascorbic acid plus standard of care or standard of care alone. The demographic …

Predicting Mitochondrial Dynamic Behavior In Genetically Defined Neurodegenerative Diseases, Gerald W Dorn Ii, Xiawei Dang

Open Access Publications

Mitochondrial dynamics encompass mitochondrial fusion, fission, and movement. Mitochondrial fission and fusion are seemingly ubiquitous, whereas mitochondrial movement is especially important for organelle transport through neuronal axons. Here, we review the roles of different mitochondrial dynamic processes in mitochondrial quantity and quality control, emphasizing their impact on the neurological system in Charcot-Marie-Tooth disease type 2A, amyotrophic lateral sclerosis, Friedrich's ataxia, dominant optic atrophy, and Alzheimer's, Huntington's, and Parkinson's diseases. In addition to mechanisms and concepts, we explore in detail different technical approaches for measuring mitochondrial dynamic dysfunction in vitro, describe how results from tissue culture studies may be applied to …

68-Year Old Man With Progressive Weakness And Ventilator Dependent Respiratory Failure: A Case Report Of Sporadic Late Onset Nemaline Myopathy, P. Kirupaharan, Daniel Kramer, Alan Gandler, Lawrence C. Kenyon, Ross Summer

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Background: Neuromuscular pathologies must be considered when caring for patients with persistent or progressive respiratory failure. Pertinent disease states may involve skeletal muscles of respiration or associated neurologic structures including motor neurons, peripheral neurons and the neuromuscular junction. Diagnosis may require pulmonary function testing, neurophysiologic studies, imaging, and/or muscle biopsy.

Case presentation: A 68-year-old male was transferred to our intensive care unit (ICU) for management of ventilator dependent respiratory failure. Upon further historical review, he described gradually worsening gait instability and muscle weakness, which was previously attributed to vascular Parkinsonism in the setting of known cerebrovascular disease. Upon arrival to …

Embryological Development And Mortality Of Danio Rerio In Long Term Exposure To 17Α-Ethynylestradiol, Seong A. Jeon

University Honors Theses

Synthetic estrogens as well as other chemicals have become an increasing issue in the impact they have on marine species particularly those sensitive to the environment. A broadly used synthetic estrogen, 17α-ethynylestradiol, has become more widely known to become a growing problem to the ecology of marine wildlife due to increased usage and lack of removal in municipal sewage treatment facilities. This study observes the impact of low level EE2 in embryos following generational exposure. Zebrafish embryos, following three generations of exposure, were observed in rate of mortality, lethality, and hatch success. Concentrations as low as 1ng/L of EE2 has …

At The Intersection Of Cardiology And Oncology: Tgfβ As A Clinically Translatable Therapy For Tnbc Treatment And As A Major Regulator Of Post-Chemotherapy Cardiomyopathy., Andrew Sulaiman, Jason Chambers, Sai Charan Chilumula, Vishak Vinod, Rohith Kandunuri, Sarah Mcgarry, Sung Kim

Manuscripts, Articles, Book Chapters and Other Papers

Triple-negative breast cancer (TNBC) is a subtype of breast cancer that accounts for the majority of breast cancer-related deaths due to the lack of specific targets for effective treatments. While there is immense focus on the development of novel therapies for TNBC treatment, a persistent and critical issue is the rate of heart failure and cardiomyopathy, which is a leading cause of mortality and morbidity amongst cancer survivors. In this review, we highlight mechanisms of post-chemotherapeutic cardiotoxicity exposure, evaluate how this is assessed clinically and highlight the transforming growth factor-beta family (TGF-β) pathway and its significance as a mediator of …

At The Intersection Of Cardiology And Oncology: Tgfβ As A Clinically Translatable Therapy For Tnbc Treatment And As A Major Regulator Of Post-Chemotherapy Cardiomyopathy, Andrew Sulaiman, Jason Chambers, Sai Charan Chilumula, Vishak Vinod, Rohith Kandunuri, Sarah Mcgarry, Sung Kim

Student Publications

Triple-negative breast cancer (TNBC) is a subtype of breast cancer that accounts for the majority of breast cancer-related deaths due to the lack of specific targets for effective treatments. While there is immense focus on the development of novel therapies for TNBC treatment, a persistent and critical issue is the rate of heart failure and cardiomyopathy, which is a leading cause of mortality and morbidity amongst cancer survivors. In this review, we highlight mechanisms of post-chemotherapeutic cardiotoxicity exposure, evaluate how this is assessed clinically and highlight the transforming growth factor-beta family (TGF-β) pathway and its significance as a mediator of …

A Non-Iteration Solution For Solving The Backward-In-Time Two-Dimensional Burgers’ Equation With A Large Reynolds Number, Yen-Shen Chang, Yung-Wei Chen, Chein-Shan Liu, Jiang-Ren Chang

Journal of Marine Science and Technology–Taiwan

This article proposes a noniteration solution based on the Lie-group shooting method (LGSM) to solve the backward-in-time two-dimensional Burgers’ equation with a large Reynolds number. The backward problem is famous for seriously ill-posed cases because the solution is generally unstable and highly dependent on the input data. Small perturbations in the input data, such as random errors inherent to the measurements in the analysis, can cause large oscillations in the solution. To handle a large Reynolds number under long time spans, it is very difficult to integrate towards the time direction. To avoid time integration and numerical iteration, the noniteration …

Polyketides And Terpenes In Marine Microalgae: Ecological Roles And Mechanisms Of Biosynthesis, Yunxuan Xie, Mohammad Elsheikh

Journal of Marine Science and Technology–Taiwan

Marine microalgae comprise a large number of polyketides and terpenes identified to date with highly diverse molecular scaffolds and the biological activities (Kalaitzis et al., 2010). These compounds play significant roles in marine food web and nutraceutical supplementation in marine animals. Compounds of this class are often synthesized by gene clusters with dedicated domains responsible for carbon chain extension and modification. The unique molecular structure of these compounds encourages people to investigate their biosynthetic mechanisms in-depth. In this review, we summarize relevant articles to unravel the shared mechanisms of these compounds to further understand the variety of domain organizations and …

Unbaited Light-Emitting Diode Traps Performance For Catching Orange Mud Crabs, Muhamad Naimullah, Kuo-Wei Lan, Mhd Ikhwanuddin, Adnan Amin-Safwan, Wei-Yu Lee

Journal of Marine Science and Technology–Taiwan

Mud crabs (Scylla spp.) are a vital fishery resource and targeted for a valuable source of income for coastal communities throughout the Indo-Pacific region. Baited traps are a considerable expense in crustacean fishing. Hence, the present study was performed to investigate the catchability of Scylla olivacea in response to light-emitting diodes (LEDs) in captivity and field conditions. We used a new experimental setup in the captivity condition that revealed most S. olivacea were attracted to green, blue, and white LED lights and no attractive effect by red LED lights similar to the controls. Field studies have shown that the catch …

Catch And Effort Standardization For Taiwanese Swordtip Squid Uroteuthis Edulis Fisheries In The Southern East China Sea, Ke-Yang Chang, Yu-Jie Hsu, Tzu-Yun Ching, Cheng-Hsin Liao, Chih-Shin Chen

Journal of Marine Science and Technology–Taiwan

The swordtip squid Uroteuthis edulis is a neritic squid species that is widely distributed within the coastal waters of subtropical and tropical Indo-western Pacific regions. This squid is a commercially important species throughout its distribution range and plays a critical role in marine ecosystems. Stock assessments of the squid in the East China Sea (ECS) are scarce, although it is crucial information for the sustainability of the squid and relevant fisheries. The squid was harvested by various fisheries in the southern ECS, which could restrict methods for catch-effort standardization. In this study, catch-effort data of Taiwanese swordtip squid fisheries in …

Uniform Torsion Analysis Of Composite Shafts Using Point Collocation Method Based On Pascal Polynomials, Chih-Wen Chang, Jyh-Hong Wu, Ying-Ru Lin, Yu-Feng Lin, Nan-Nong Huang

Journal of Marine Science and Technology–Taiwan

Torsion bars are important elements in the marine structure applications. The usage of the composite torsion bars has increased recently because it takes advantage of the different material property of each constituent. The current research focuses mainly on the uniform warping analysis of composite torsion shafts by using the point collocation method (PCM). The PCM is based on Pascal's triangle polynomial expansion and coupled with subdomain technique that is indispensable for the analysis of composite bars. In addition to satisfying the field equation (Laplace equation for warping function) and traction-free boundary condition for each component, the continuity conditions in both …

Local Reinforcement Design And Safety Factor Evaluation Of Elliptical Hatch Of Pressure Hull, Guang-Min Luo, Jun-Wei Chen

Journal of Marine Science and Technology–Taiwan

A pressure hull is the primary pressure-resistant structure of a submarine. To safeguard the compressive strength of such a hull, local structural reinforcement is required for various hatches on the hull. Hatches are commonly reinforced through increasing the thickness of the hull regions around them; alternatively, hatch nozzle walls are connected with stiffened frames to maintain the continuity of reinforced structures. This study focused on a pressure hull with an elliptical hatch. A PD-5500 cylindrical pressure hull was used to design a cylindrical pressure hull structure, and a model of hatch nozzle reinforcement was designed using the Boiler and Pressure …

Effects Of Dietary Lipid, L-Carnitine And L-Lysine Supplementation On The Growth Performance And Body Composition Of Epinephelus Lanceolatus Larvae, Jen-Hong Chu, Yu-Cong Hong, Angela Chien, Shyn-Shin Sheen

Journal of Marine Science and Technology–Taiwan

The effects of different combinations of dietary lipid, L-carnitine and L-lysine on the growth performance and fatty acid profiles of larval grouper Epinephalus lanceolatus were evaluated. Eight treatment diets were formulated based on a 2x2x2 factorial design, namely 5 and 14% dietary oil mixture (3:1 fish oil/soybean oil), 0 and 0.5% L-carnitine and 0 and 2.83% L-lysine. Each diet was randomly assigned to triplicate groups of ten 0.08g E. lanceolatus larvae for 42 days. The grouper larvae fed with diets containing 14% lipid had significantly higher weight gain percentages than those fed with diets containing 5% lipid. The weight gain …

Criteria Of Initial Selection Of Candidates For Artistic Gymnastics, Kazimierz Kochanowicz, Andrzej Kochanowicz

Baltic Journal of Health and Physical Activity

Background: The effectiveness of the training process and the level of sports results largely depend on the selection of candidates with appropriate psycho-physical predispositions and the efficiency of the training system. Therefore, selection for artistic gymnastics must be based on coaches' thorough knowledge regarding physical development, interdependence of particular systems and analysers, motor skills and mental determinants. The aim of the study was to develop quantitative criteria of initial selection of candidates for artistic gymnastics. Material/Methods: The study material comprised 319 boys aged 6 qualified for gymnastic training at the Interschool Sports Club and the Academic Sports Association of the …

Relations Between Bioelectrical Muscles Activity And Isokinetic Strength Parameters In 17–19-Year-Old Judoists, Marcin Dornowski

Baltic Journal of Health and Physical Activity

Background: Muscle strength as an element of preparation and sport competition is one of the most important aspects in technical and tactical efficiency. The aim of this study was to define the level of relation between bioelectrical muscle activity and isokinetic strength parameters in 17–19-year-old judoists. Material/Methods: 30 judo athletes (17–19-year-old) took part in the research. The research was conducted in Gdańsk Academy of Physical Education and Sport Laboratory during 2006–2008. In the research authors used: to evaluate the isokinetic strength level, ”Concept 2 Dyno” device was used in the research, along with surface summary electrical bio-potentials reading on EMG …

Individualities Of Cardiorespiratory Responsiveness To Shifts In Respiratory Homeostasis And Physical Exercise In Homogeneous Groups Of High Performance Athletes, Viktor Mishchenko, Oksana Shynkaruk, Andrzej Suchanowski, Olena Lysenko, Tomasz Tomiak, Andrej Diachenko, Adam Korol

Baltic Journal of Health and Physical Activity

Background: It is known that high sports performances are based upon optimization of adaptation process. In order to achieve the above, one should provide a maximal account of individual vivid features of athlete's abilities, peculiarities of his/her physiological reactivity. The aim was to study individualities of sensitivity to shifts in respiratory homeostasis and responsiveness to high intensity physical exercises in homogeneous groups of high performance endurance athletes. Material/Methods: Individual peculiarities of the cardiorespiratory system (CRS) physiological reactivity were evaluated in 118 high performance endurance athletes (cyclists, runners and rowers) aged 20-27 years (competing regularly in sports for 6.8 ± 1.1 …

Cardiorespiratory Responses To Submaximal Exercise In 16-18-Year-Old Trained And Untrained Boys, Marcin Luszczyk, Ewa Ziemann, Tomasz Grzywacz, Radoslaw Laskowski, Anna Szczesna-Kaczmarek

Baltic Journal of Health and Physical Activity

Background: The aim of this study was to compare chosen parameters and coefficients characterizing the action of the cardiovascular system and the respiratory system at a low level of a cycloergometric exercise in young boys practicing handball and their untrained peers. In the present study we searched for an answer to questions concerning the influence of physical training on children’s organism in progressive youth development. Material/Methods: The technique of parallel groups was used: the experimental one (boys training handball, n=12) and the control one (not trained boys, n=58). The developmental age of the subjects was evaluated by percentile charts. A …

Sport Activity – Systematic Approach To Science, Technology And Art. Part Two: Engineering Technology And Sport, Wlodzimierz S. Erdmann

Baltic Journal of Health and Physical Activity

Technology is involved in creating new objects, processes, structures, dependencies that have never existed before. Engineering technology of creating new material objects or preparing spaces for different human or animal activity encompasses: 1) engineering sciences, 2) engineering processes of production, 3) products and spaces. Within engineering sciences there are: metrology, material science, energy science, machine science, electro-technique, electronics, automation, robotics, informatics, and tele-communication. The engineering process consists of several stages: analysis of needs, designing, production, usage and maintenance, fixing and parts exchange, waste disposal, marketing, development of products. The sport of today has the same aims as earlier: competitors must …

Deviant Behaviour In Competitive Sport. A Sociological Attempt At Explaining The Phenomenon, Zbigniew Dziubinski

Baltic Journal of Health and Physical Activity

This article seeks to use selected sociological theories to account for the phenomenon of deviance in sport. Two main theoretical approaches are employed herein: the functionalist/structuralist approach and symbolic interactionism. The analysis that follows leads to the conclusion that deviance which occurs in sport is predominantly a consequence of deviance in modern societies. Sport, in turn, is just a convenient area for deviant behaviours to be manifested, which often happens more clearly and conspicuously than in societies.

Having Children And Physical Activity Level And Other Types Of Pro-Health Behaviour Of Women From The Perspective Of The Theory Of Planned Behaviour, Piotr Wlodarczyk, Artur Ziolkowski

Baltic Journal of Health and Physical Activity

Background: The subject of the paper is pro-health behaviour of women (N=477) who have children (N=124) and those who have no children (N=353). The Theory of Planned Behaviour (TPB) by Icek Ajzen, in the light of which the differences in the health behaviour level of the sample group are considered, constitutes the theoretical basis of this work. Material/Methods: The research group consisted of women at the age of 19–36 (M=27,5 yrs of age SD=4 yrs of age). The Health and Behaviour Survey Questionnaire by Steptoe and Wardle was used for the measurement. Four scales of healthy behaviour values, i.e., taking …

Changes In The Prevalence Of Excessive And Deficient Body Weight Among Pomeranian Youth In The Years 1979, 1989, And 1999, Anna Lysak, Janusz Dobosz, Jozef Drabik

Baltic Journal of Health and Physical Activity

Background: The analysis presented in this paper aimed to identify trends in the prevalence of the two extremes of body fat disorders over a period of 20 years (1979–1999) and to form a comparative basis for further studies of physical development of the youth of the Pomerania region. Material/Methods: The study population consisted of 23,854 boys and girls aged 7 to 18 years attending schools in rural and urban areas in the Pomerania administrative region. An overweight and underweight population was identified based on the body mass index (BMI) according to WHO, CDC and the Mother and Child Institute recommendations. …

Selected Socio-Educational And Personal Aspects Of Conditioning Attitudes Of Fair Play In Sport, Artur Ziolkowski, Wojciech Saklak, Piotr Wlodarczyk

Baltic Journal of Health and Physical Activity

Background: It is becoming more realistic in sport to experience and achieve certain qualities that create 'the highest good'. One of the conditions of this transgression is to obey categorically the rules of fair play. Material/Methods: This paper describes personal, social and educational determinants of moral values represented by young athletes. 212 young sportsmen were selected for purposes of this research. They were students from schools with religious and sports background. Results: The results of the research show the relation between levels of morality of fair play in sport and preferred attitudes as well as educational and religious influence of …

Special Fitness And The Effectiveness Of Technical Preparation In Gymnastic Vault Event In Athletes At The Directed Stage, Andrzej Kochanowicz, Kazimierz Kochanowicz, Stanislaw Sawczyn

Baltic Journal of Health and Physical Activity

Background: The aim of the study was to determine the correlation between individual profiles of leading traits of special fitness with athletes' technical preparation in the gymnastic vault event at the directed stage of training. Material/Methods: The study involved 60 gymnasts aged 11-13 practising artistic gymnastics at the stage of directed training. The study was carried out in laboratory, training and sports competition conditions in years 2003 – 2007. Results: An analysis of results enabled determining the most informative indices having a significant relation with the sports results in gymnastic vault. Quantitative criteria of special fitness and technical preparation in …