Digital Commons Network^™

April 28, 2022, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

April 28, 2022, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Isolation And Characterization Of Potential Lactic Acid Producing Bacteria From Fermented Fruit Juice, Than Wah Wah, Maw Saw Sandar, Htun Reemon

ASEAN Journal on Science and Technology for Development

Lactobacillus species are used as probiotics to inhibit human pathogens because of their ability to produce antimicrobial substances. However, when different kinds of antibiotics are used, the antibiotic resistance of drug-resistant bacteria increases. In this study, lactic acid-producing bacteria with antimicrobial activity were isolated and used as probiotics to inhibit six human pathogens, namely Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Bacillus cereus, Salmonella typhi, and Shigella boydii. Nine bacterial isolates were obtained from the crude juice of sugar cane (Saccharum officinarum), strawberry (Fragaria ananassa), and fruit pulp of palm (Borassus flabellifer). Among them, three bacterial isolates (S1, SC, and PP) …

Deepening Knowledge Of Nutrient Dynamics In Coastal Waters, Meirinawati Hanny, Wahyudi A'An Johan

ASEAN Journal on Science and Technology for Development

Nutrients are important compounds in waterbodies that regulate primary productivity and phytoplankton growth, the basis of food webs. Increased nutrient concentration has become a serious concern because it causes eutrophication and threatens the sustainability of ecosystems. Eutrophication is the process of nutrient enrichment in water bodies that affects their productivity and decreases water quality. Although information about nutrient distribution, limiting nutrients, and nutrient budgets is important for coastal water management, studies of wide-scale nutrient dynamics in Indonesian waters remain limited. To provide comprehensive data on nutrients, this review summarized the concentrations and compositions of nutrients in coastal waters, compared the …

Comparison Of Five Supervised Feature Selection Algorithms Leading To Top Features And Gene Signatures From Multi-Omics Data In Cancer

Faculty, Staff and Student Publications

BACKGROUND: As many complex omics data have been generated during the last two decades, dimensionality reduction problem has been a challenging issue in better mining such data. The omics data typically consists of many features. Accordingly, many feature selection algorithms have been developed. The performance of those feature selection methods often varies by specific data, making the discovery and interpretation of results challenging.

METHODS AND RESULTS: In this study, we performed a comprehensive comparative study of five widely used supervised feature selection methods (mRMR, INMIFS, DFS, SVM-RFE-CBR and VWMRmR) for multi-omics datasets. Specifically, we used five representative datasets: gene expression …

Dance Of The Golgi: Understanding Golgi Dynamics In Cancer Metastasis, Rakhee Bajaj, Amanda N Warner, Jared F Fradette, Don L Gibbons

Faculty, Staff and Student Publications

The Golgi apparatus is at the center of protein processing and trafficking in normal cells. Under pathological conditions, such as in cancer, aberrant Golgi dynamics alter the tumor microenvironment and the immune landscape, which enhances the invasive and metastatic potential of cancer cells. Among these changes in the Golgi in cancer include altered Golgi orientation and morphology that contribute to atypical Golgi function in protein trafficking, post-translational modification, and exocytosis. Golgi-associated gene mutations are ubiquitous across most cancers and are responsible for modifying Golgi function to become pro-metastatic. The pharmacological targeting of the Golgi or its associated genes has been …

Targeting Cd123 In Blastic Plasmacytoid Dendritic Cell Neoplasm Using Allogeneic Anti-Cd123 Car T Cells, Tianyu Cai, Agnès Gouble, Kathryn L Black, Anna Skwarska, Ammar S Naqvi, Ming Zhao, Mayumi Sugita, Qi Zhang, Roman Galetto, Stéphanie Filipe, Antonio Cavazos, Lina Han, Vinitha Kuruvilla, Helen Ma, Connie Weng, Chang-Gong Liu, Xiuping Liu, Sergej Konoplev, Jun Gu, Guilin Tang, Xiaoping Su, Gheath Al-Atrash, Stefan Ciurea, Sattva S Neelapu, Andrew A Lane, Hagop Kantarjian, Monica L Guzman, Naveen Pemmaraju, Julianne Smith, Andrei Thomas-Tikhonenko, Marina Konopleva

Faculty, Staff and Student Publications

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy with poor outcomes with conventional therapy. Nearly 100% of BPDCNs overexpress interleukin 3 receptor subunit alpha (CD123). Given that CD123 is differentially expressed on the surface of BPDCN cells, it has emerged as an attractive therapeutic target. UCART123 is an investigational product consisting of allogeneic T cells expressing an anti-CD123 chimeric antigen receptor (CAR), edited with TALEN

Peripheral Storytelling: Cinematic Structures And Audience Agency, Carlos Tkacz

Far West Popular Culture Association Annual Conference

A cultural phenomenon we are all unfortunately familiar with is terrible movies. By terrible movies I mean the kind that lack any semblance of structure, movies in which the characters are flatly drawn, the storylines are predictable, and the writing is especially bad. More specifically, I am interested in why these movies seem to be breeding without end and are no longer relegated to (maybe they never were) the low budget genre films some of us love to hate. I am talking here about the relatively new phenomena of the high-budget, popular-yet-terrible film.

Specifically, I am interested in applying Structuralism, …

Feasibility, Necessity, And Rebellion Of Collective Authenticity As Understood Through Heidegger And Fanon, Victor Hernandez

Undergraduate Library Research Awards

No abstract provided.

Medication-Induced Oculomotor Dysfunction: A Report Of Two Cases, Eric Lee Od

Optometric Clinical Practice

Background: Consideration of current medications and their interactions as a source of new onset oculomotor dysfunction is imperative for providing good eye care. Medication etiology should be particularly suspected when the symptoms begin with the initiation of a new medication and resolved with discontinuation of the same medication.

Case Reports: Presented are two cases demonstrating that it is prudent to be aware of medications capable of inducing oculomotor dysfunction. Each case reveals instances of acute oculomotor dysfunction after the initiation of a central nervous system affecting medication. Case 1 details a partial pupil sparing third nerve palsy after initiating the …

Longstanding Crystalline Retinopathy Secondary To Intravitreal Triamcinolone Injection, Katherine Thomas Od, Jeffery Curry Od

Optometric Clinical Practice

Background: Crystalline retinopathy has many disparate etiologies with varying potentials in visual outcome. Due to the potential severity of these outcomes, differentiation of etiology is critical to guide both follow up and treatment regimen. Diagnosis can be facilitated with a thorough medical history, clinical presentation, and imaging such as optical coherence tomography (OCT).

Case Report: This case demonstrates a rare incidence of crystalline retinopathy in a 65-year-old male attributed to a single intravitreal triamcinolone acetonide (IVTA) injection with 8 year follow up data, followed by a review of other types of crystalline retinopathy secondary to pharmaceutical agents.

Conclusion: A complete …

Light Dependent Feeding And Photogrammetric Determination Of Movement Speed Of Pterois Volitans And Pterois Miles In The Florida Keys, Neal Kolonay

LSU Master's Theses

Invasive species are known to cause economic and ecological damage worldwide, with many aquatic and terrestrial species extending outside their range. Invasive lionfish, Pterois volitans and Pterois miles, are currently some of the most destructive marine species, being released into non-native Atlantic waters, gaining a foothold, and expanding at explosive rates. While attempts have been made to cull their populations through various methods, primarily spearfishing, their populations continue to grow and their ranges expand showing a need for a deeper understanding of their ecology to more effectively model and target them. In this work, two avenues of lionfish ecology which …

Adoption Communication In The Media, Samantha Schaffer

Far West Popular Culture Association Annual Conference

Adoption communication is a vital part of developing healthy family relationships in families formed through adoption. The media has recently begun depicting more of the difficulties that adoptees experience. Three key television shows are Charmed, A Million Little Things, and This Is Us, which depict communication about adoption. These television shows offer the opportunity to analyze master narratives, family communication patterns, and information regulation through popular culture. By illustrating the difficulties experienced by adoptees, these shows provide adoptive families with the occasion to begin difficult yet necessary conversations. These television shows not only exemplify adoption communication they also …

Can Green Tea Extract Promote Weight Loss?, Kelly Jehle

Undergraduate Library Research Awards

No abstract provided.

Sleepless In College Town: Causes And Effects Of Poor Sleep In College Students, Isabella E. Pandolfo

The Review: A Journal of Undergraduate Student Research

This article is an examination of the various causes and effects of sleep deprivation and poor sleep quality in college students. Using various studies and articles as evidence, this review explores the causes of sleep deprivation in college students, and addresses the ways in which other parts of one's well-being may suffer as a result of sleep deprivation. The nature of life as a college student is not conducive to good quality sleep or sufficient amount of sleep, and the various detrimental factors to sleep quality, such as napping, technology, and social factors contribute to problems in other areas. According …

Covid Susceptibility And Severity Correlation With The Ace2 Gene, Natalie Taylor

Thinking Matters Student Research Symposium

A wide spectrum of susceptibility and severity of infection has been observed among COVID-19 patients. While some individuals remain unaffected by the Sars-Cov-2 virus, others have contracted the virus multiple times with varying levels of severity. This poster reviews some of the research demonstrating a link between the susceptibility of the Sars-Cov- 2 virus and the severity of infection, and a specific gene called ACE2. The ACE2 gene encodes an angiotensin-converting enzyme that acts as a functional receptor for the spike glycoprotein receptor binding domain of the coronavirus and severe acute respiratory syndrome coronaviruses. ACE2 presents numerous amino acid variants …

2021-2022 Program And Abstracts: Celebration Of Student Scholarship, Morehead State University. Undergraduate Research Fellowship Program.

2022 Celebration of Student Scholarship - Poster Presentations

The 2021-2022 Program and Abstracts for the Celebration of Student Scholarship at Morehead State University held on April 27, 2022. A Showcase of Student Research, Scholarship, Creative Work, and Performance Arts.

Drivers Of Macroinvertebrate Community Integrity Within Mixed Urban And Agricultural Dominated Mississippi Tributary Watersheds, Matthew R. Straus, Bethany Mabel Lian Schorr, Kevin Geedey, Michael Reisner, Benjamin Ford

Biology: Student Scholarship & Creative Works

The “urban stream syndrome” refers to a multitude of impacts caused by urbanization including flashier hydrograph, elevated concentrations of nutrients and contaminants, altered channel morphology and stability, reduced biotic richness, with increased dominance of tolerant species, reduced base flow and increased suspended solids. The drivers of these “symptoms” include impervious surfaces, piping in stormwater drainages, habitat and forest loss, water supply and sewer leaking, and direct alterations to channel morphology and flow. The goal of this study was to assess the integrity of the macroinvertebrate community and determine the most significant drivers of such integrity at the catchment, riparian zone, …

Investigation Of Cotinine Concentration Found In Saliva Of Smokers And Vapers In Demographic Sectors, Seth A. Sims

Honors Theses

A simple and reproducible method for investigation of cotinine and nicotine levels in saliva was developed by utilizing gas chromatography mass spectrometry (GCMS) and simple extraction techniques. This method allowed for accurate detection of cotinine in saliva samples collected within a 50-mile radius of Searcy, AR. The observed cotinine levels proportionately depict nicotine levels, which were then compared with participants’ demographics, displaying trends among different communities. This research hopes to provide insight into vaping popularity as well as a reproducible method that future research can utilize.

Lactobacillus Gasseri Growth Curve In The Presence Of Oxalate, Jamya Patterson

Honors Capstone Projects and Theses

No abstract provided.

We Are ... Marshall, April 27, 2022, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

The Women Of Owen Clinic And Their Impact On Rural Mental Health, Mallory Stanley

Manuscripts

The mid-1900s was a pivotal moment in reforming mental health treatment in American Psychiatry. This movement becomes particularly clear when examining the championing work of two women, Dr. Thelma V. Owen and Dr. M. G. Stemmermann, at a rural mental health facility located in Huntington, WV: Owen Clinic Institute. While mental health stigma was at an extreme high among the general population, many factors aligned to allow for a new era of mental health care, including deinstitutionalization, World War II, and the advocation of professionals in the field. In West Virginia, no two people were more outspoken and active in …

Breaking Things: Origins And Consequences Of Racialized Hate Speech On Facebook, Katherine Herrick

International Studies Honors Projects

This thesis seeks to bring attention to the ways in which the effects of hate speech--specifically racialized hate speech--transcends digital platforms. It will begin by connecting the phenomenon of racialized hate speech on Facebook to specific psychological tendencies that the company consciously amplifies for its own financial benefit. The first chapter interrogates the common narrative that violent rhetoric indicates a flaw in the platform’s design, instead arguing that proliferation of such content is encouraged by Facebook’s algorithm. From there, the second chapter examines what happens when a technology giant leverages human psychology for corporate greed. A true worst-case scenario, the …

Sum Christiana: Perpetua's Patriarchy-Defeating Agency, Katherine Mccarthy

Religious Studies Honors Projects

The early Christian text, Passio sanctarum Perpetuae et Felicitatis, outlines the martyrdom of Vibia Perpetua and fellow catechumens in North Africa in 203 B.C. By looking at the original Latin text and contextualizing the story in its Carthiginian context and focusing on the words exchanged between Perpetua and her paterfamilias and the descriptions concerning them, this deeper analysis situates Perpetua’s agency. Perpetua inverts the role of the paterfamilias, which can be seen through her language choice. Moreover, Perpetua’s paterfamilias’ change in word choice reflects Perpetua’s ability to make her own choices in the male-dominated Roman society. Perpetua defies societal, gender, …

Celebration Of Faculty Scholarship 2021, Olin Library

Celebration of Faculty Scholarship

No abstract provided.

New State Records For 33 Species Of Nearctic False Click Beetles (Coleoptera: Eucnemidae), Robert L. Otto

Insecta Mundi

New state records for 33 species of Eucnemidae (Coleoptera) are reported from the eastern United States based on the examination and identifications of specimens from four institutional and personal collections over the past several years. Images of 12 eucnemid species are also provided.

Recently, opportunities were presented to identify more than 880 Eucnemidae from four institutional and personal collections. Most of the specimens came from the Carnegie Museum of Natural History and were collected during the national bark beetle surveys conducted by the United States Department of Agriculture. The survey has been instrumental in providing more state records of Eucnemidae …

The Connections Between Innovation, Culture, And Expertise In Water Infrastructure Organizations, Alice Brawley-Chesworth

Dissertations and Theses

Infrastructure organizations are notoriously conservative and resistant to change, even when faced with wicked problems that cannot be solved with the same thinking used in the past. In the water sector, this resistance to change has been linked to an industry culture that is based in a single, engineering-oriented knowledge system. Scholars have suggested that diversification of knowledge systems is necessary for implementation of innovations that will move the sector forward to solve wicked problems.

This research used a qualitative case study approach comparing two water sector organizations in Portland, Oregon. One organization included members who shared an engineering knowledge …

The Relationship Between Blast-Related Mild Traumatic Brain Injury And Executive Function Is Associated With White Matter Integrity, Molly C. O'Brien

Neuroscience Honors Projects

This project details the outcomes of mild traumatic brain injury (mTBI) including injury mechanism, immunological response, and cognitive performance. The study investigates if the integrity of certain brain regions influences the association between remote mTBI and executive function. Based on data from 182 veterans from the Minneapolis VA Medical Center, an association between blast injury severity and executive function was found to be moderated by white matter integrity of the right hippocampal cingulum in veterans with blast exposure history, such that those with higher blast severity showed a greater effect of the association between lower integrity and worse performance.

Celebrating Faculty Scholarship 2021/22, Smith College Libraries

Celebrating Faculty Scholarship: Bibliographies

Scroll down to view the bibliography of selected scholarly and creative work produced by Smith College faculty and submitted by faculty for the 2022 celebration which took place in the Neilson Library Skyline Reading Room, Smith College on April 27, 2022.

A Patient-Derived Ipsc Model To Study Glutamate Deficiency By Shank-3 Mutation In Autism Spectrum Disorder, Tiffany Berry, Courtney Caccia

Biology Student Scholarship

Tiffany Berry ’22, Majors: Biology and Psychology

Courtney Caccia ’22, Majors: Biology and Psychology

Faculty Mentor: Dr. Charles Toth, Biology

The use of human stem cell lines derived from persons with Autism Spectrum Disorder (ASD) provides a unique opportunity to model brain growth and potential to regain brain activity for treatment. Our lab has previously used stem cells to derive 3D cardiomyocytes to examine cardiovascular disease as well as kidney organoids and macrophages to study kidney disease. Using techniques our lab has learned using these stem cell models have prepared us to examine cell communication in mutated neurons. We will …