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Articles 14551 - 14580 of 818213
Full-Text Articles in Entire DC Network
Daily Locomotor Activity Declines With Tumor Growth And Disease Progression In Glioblastoma, Maria F Gonzalez-Aponte, Sofia V Salvatore, Anna R. Damato, Ruth Gn Katumba, Grayson R. Talcott, Omar H. Butt, Jian L. Campian, Jingqin Luo, Joshua B. Rubin, Olivia J. Walch, Erik D. Herzog
Daily Locomotor Activity Declines With Tumor Growth And Disease Progression In Glioblastoma, Maria F Gonzalez-Aponte, Sofia V Salvatore, Anna R. Damato, Ruth Gn Katumba, Grayson R. Talcott, Omar H. Butt, Jian L. Campian, Jingqin Luo, Joshua B. Rubin, Olivia J. Walch, Erik D. Herzog
2020-Current year OA Pubs
Glioblastoma (GBM) is an aggressive brain tumor that often progresses despite resection and treatment. Timely and continuous assessment of GBM progression is critical to expedite secondary surgery or enrollment in clinical trials. However, current progression detection requires costly and specialized MRI examinations, which, in the absence of new symptoms or signs, are usually scheduled every 2-3 months. Here, we hypothesized that changes in daily activity are associated with GBM growth and disease progression. We found that wheel-running activity in GBM-bearing mice declined as tumors grew and preceded weight loss and circadian breakdown by over a week. Temozolomide treatment in the …
The Yeh Pilus Adhesin Is Equipped With An Α-Helical Flap Motif, Which Contributes To Pectin Adherence, Kevin O Tamadonfar, Roger D Klein, Edward D B Lopatto, Maxwell I Zimmerman, Philippe N Azimzadeh, Denise A Sanick, Justin R Porter, Jesus Bazan Villicana, Jerome S Pinkner, Bo Huey Chiang, Nathaniel C Gualberto, Karen W Dodson, Michael L Patnode, George M H Et Al., Gregory R Bowman, Scott J Hultgren
The Yeh Pilus Adhesin Is Equipped With An Α-Helical Flap Motif, Which Contributes To Pectin Adherence, Kevin O Tamadonfar, Roger D Klein, Edward D B Lopatto, Maxwell I Zimmerman, Philippe N Azimzadeh, Denise A Sanick, Justin R Porter, Jesus Bazan Villicana, Jerome S Pinkner, Bo Huey Chiang, Nathaniel C Gualberto, Karen W Dodson, Michael L Patnode, George M H Et Al., Gregory R Bowman, Scott J Hultgren
2020-Current year OA Pubs
The Yeh chaperone-usher pathway (CUP) pilus adhesin is encoded in one-half of all
A Prescription For Ineffective Notice In Mhealth, Tatyana Norman-Webler
A Prescription For Ineffective Notice In Mhealth, Tatyana Norman-Webler
Akron Law Review
No abstract provided.
Soft Law Governance Of Artificial Intelligence In Healthcare, Gary E. Marchant
Soft Law Governance Of Artificial Intelligence In Healthcare, Gary E. Marchant
Akron Law Review
No abstract provided.
The Archon, 1949 Edition, Zeta Phi Beta Sorority Incorporated
The Archon, 1949 Edition, Zeta Phi Beta Sorority Incorporated
Josie Green Washington Papers
A 1949 edition pamphlet called The Archon, an official organ of the Zeta Phi Beta Sorority.
Animal Taxa Threatened By Adverse Fire Regimes In Western Australia: A Synthesis And Outlook, Tim S. Doherty, Mark G. Allen, Karlene Bain, Stephen Beatty, Allan H. Burbidge, Renee A. Catullo, Sarah Comer, Ben Corey, Saul J. Cowen, Robert A. Davis, Martin A. Dziminski, J. Anthony Friend, Bruce Greatwich, Mark S. Harvey, Hannah Killian, Michael E. Klunzinger, Damian C. Lettoof, Nicola J. Mitchell, Melinda Moir, Harry A. Moore, David L. Morgan, Ian J. Radford, Michael J. Rix, Tom Vigilante, Adrian F. Wayne, Corey Whisson, Nicole Willers, Matthew R. Williams
Animal Taxa Threatened By Adverse Fire Regimes In Western Australia: A Synthesis And Outlook, Tim S. Doherty, Mark G. Allen, Karlene Bain, Stephen Beatty, Allan H. Burbidge, Renee A. Catullo, Sarah Comer, Ben Corey, Saul J. Cowen, Robert A. Davis, Martin A. Dziminski, J. Anthony Friend, Bruce Greatwich, Mark S. Harvey, Hannah Killian, Michael E. Klunzinger, Damian C. Lettoof, Nicola J. Mitchell, Melinda Moir, Harry A. Moore, David L. Morgan, Ian J. Radford, Michael J. Rix, Tom Vigilante, Adrian F. Wayne, Corey Whisson, Nicole Willers, Matthew R. Williams
Natural Resources Research Articles
Adverse fire regimes threaten biodiversity, potentially leading to population declines and increased extinction risk. Understanding how varying fire regimes affect threatened species is essential for effective ecosystem management, including in Western Australia where diverse ecosystems are exposed to wildfires, Indigenous burning, and prescribed fire. We compiled and synthesised data on the threat of adverse fire regimes to threatened animal taxa in Western Australia. Using a threat classification scheme, we ranked adverse fire regimes as having either no, low, medium, high, or unknown impact on each taxon. A total of 212 taxa were reviewed, 153 (72%) of which are considered fire-threatened: …
Cortical Hierarchy And Aphasia Severity: The Sensorimotor–Association Gradient Modulates Lesion Effects Within Language-Specific Networks, Ida Rangus, Natalie Busby, Nicholas Riccardi, Sigfus Kristinsson, Janina Wilmskoetter, Dirk B. Den Ouden, Chris Rorden, Roger Newman-Norlund, Julius Fridriksson Ph.D., Leonardo Bonilha
Cortical Hierarchy And Aphasia Severity: The Sensorimotor–Association Gradient Modulates Lesion Effects Within Language-Specific Networks, Ida Rangus, Natalie Busby, Nicholas Riccardi, Sigfus Kristinsson, Janina Wilmskoetter, Dirk B. Den Ouden, Chris Rorden, Roger Newman-Norlund, Julius Fridriksson Ph.D., Leonardo Bonilha
Faculty Publications
Aphasia severity after stroke varies widely and is not fully explained by lesion size or location. We propose that incorporating the brain’s sensorimotor-association (S-A) gradient, reflecting cortical hierarchy, offers a biologically grounded framework for predicting language outcomes. In 236 individuals with chronic left-hemisphere stroke, we examine whether the hierarchical position of lesions in language-specific (LS) and domain-general (DG) areas modulates aphasia severity. We parcellate lesions using a cortical atlas and weigh them by each region’s S-A rank. We apply hierarchical linear regression to test whether S-A ranking and its interaction with lesion volume improves prediction of Western Aphasia Battery-Revised Aphasia …
Oer Textbook Review For Human Inheritance - Chromosomes, Genes, And Traits - An Introduction To Genetics, Maria Lazebnik
Oer Textbook Review For Human Inheritance - Chromosomes, Genes, And Traits - An Introduction To Genetics, Maria Lazebnik
Open Educational Resources Publications
This review evaluates the adoption and classroom integration of the open educational resource Chromosomes, Genes, and Traits: An Introduction to Genetics for NAS322: Human Inheritance. The instructor found the OER to be comprehensive, accurate, and well aligned with core human genetics concepts, though some content areas—particularly mutations and certain visual diagrams—required supplementation or revision. The flexibility of the OER allowed for significant reorganization, modular use, and removal of non-human examples to better suit course objectives. Integration into Brightspace improved accessibility, reduced student confusion around textbook requirements, and enhanced engagement through direct linking and built-in quizzes. Compared to the previously used …
Educational Policies Committee Agenda January 8, 2026, Utah State University
Educational Policies Committee Agenda January 8, 2026, Utah State University
Educational Policies Committee
- Approval of Minutes - December 4, 2025
- Subcommittee Reports
- Curriculum Subcommittee
- Academic Standards Subcommittee
- General Education Subcommittee
- Other Business
- Adjourn: 4:00 pm
Structural Basis For The Subtype-Selectivity Of KCa2.2 Channel Activators, Young-Woo Nam, Alena Ramanishka, Yang Xu, Rose Marie Haynes Yasuda, Joshua A. Nasburg, Dohyun Im, Meng Cui, K. George Chandy, Heike Wulff, Miao Zhang
Structural Basis For The Subtype-Selectivity Of KCa2.2 Channel Activators, Young-Woo Nam, Alena Ramanishka, Yang Xu, Rose Marie Haynes Yasuda, Joshua A. Nasburg, Dohyun Im, Meng Cui, K. George Chandy, Heike Wulff, Miao Zhang
Pharmacy Faculty Articles and Research
Small-conductance (KCa2.2) and intermediate-conductance (KCa3.1) Ca2+-activated K+ channels are gated by a Ca2+-calmodulin dependent mechanism. NS309 potentiates the activity of both KCa2.2 and KCa3.1, while rimtuzalcap selectively activates KCa2.2. Rimtuzalcap has been used in clinical trials for the treatment of spinocerebellar ataxia and essential tremor. We report cryo-electron microscopy structures of NS309-bound KCa2.2 and KCa3.1, in addition to structures of rimtuzalcap-bound KCa2.2 and mutant KCa3.1_R355K. The different conformations of calmodulin and the cytoplasmic HC helices in the …
Curriculum Subcommittee Agenda January 8, 2026, Utah State University
Curriculum Subcommittee Agenda January 8, 2026, Utah State University
Educational Policies Committee
- Approval of Minutes - December 4, 2025
- R401 - Program Proposals
- Semester Course Approval Reviews
- Other Business
- UCC and EPC Handbook updates
- Adjourn: 3:00 pm
Ga4gh Phenopacket-Driven Characterization Of Genotype-Phenotype Correlations In Mendelian Disorders., Lauren Rekerle, Daniel Danis, Filip Rehburg, Adam S L Graefe, Viktor Bily, Andrés Caballero-Oteyza, Pilar Cacheiro, Leonardo Chimirri, Jessica X Chong, Evan Connelly, Bert B A De Vries, Alexander J M Dingemans, Michael H Duyzend, Tomas Freiberger, Petra Gehle, Tudor Groza, Peter Hansen, Julius O B Jacobsen, Adam Klocperk, Markus S Ladewig, Michael I Love, Allison J Marcello, Alexander Mordhorst, Monica C Munoz-Torres, Justin Reese, Catharina Schuetz, Damian Smedley, Timmy Strauss, Ondrej Vladyka, David Zocche, Sylvia Thun, Christopher J Mungall, Melissa A Haendel, Peter N Robinson
Ga4gh Phenopacket-Driven Characterization Of Genotype-Phenotype Correlations In Mendelian Disorders., Lauren Rekerle, Daniel Danis, Filip Rehburg, Adam S L Graefe, Viktor Bily, Andrés Caballero-Oteyza, Pilar Cacheiro, Leonardo Chimirri, Jessica X Chong, Evan Connelly, Bert B A De Vries, Alexander J M Dingemans, Michael H Duyzend, Tomas Freiberger, Petra Gehle, Tudor Groza, Peter Hansen, Julius O B Jacobsen, Adam Klocperk, Markus S Ladewig, Michael I Love, Allison J Marcello, Alexander Mordhorst, Monica C Munoz-Torres, Justin Reese, Catharina Schuetz, Damian Smedley, Timmy Strauss, Ondrej Vladyka, David Zocche, Sylvia Thun, Christopher J Mungall, Melissa A Haendel, Peter N Robinson
Faculty Research 2026
Comprehensively characterizing genotype-phenotype correlations (GPCs) in Mendelian disease would create new opportunities for improving clinical management and understanding disease biology. However, heterogeneous approaches to data sharing, reuse, and analysis have hindered progress in the field. We developed Genotype-Phenotype Statistical Evaluation of Associations (GPSEA), a software package that leverages the Global Alliance for Genomics and Health (GA4GH) Phenopacket Schema to represent case-level clinical and genetic data about individuals. GPSEA applies an independent filtering strategy to boost statistical power to detect categorical GPCs represented by Human Phenotype Ontology terms. GPSEA additionally enables visualization and analysis of continuous phenotypes, clinical severity scores, and …
Metacommunity Coupled Epidemiological And Biophysical Modeling Of An Emergent Coral Disease, Benjamin Holmes Farmer
Metacommunity Coupled Epidemiological And Biophysical Modeling Of An Emergent Coral Disease, Benjamin Holmes Farmer
LSU Doctoral Dissertations
Emerging infectious diseases pose imminent risk to the marine realm and coral reefs in particular. Since its emergence in 2014, stony coral tissue loss disease (SCTLD) has dramatically reduced living coral cover in Florida and charted a similar course in the Caribbean. SCTLD is by far the most severe coral disease in history and has driven highly susceptible species to local extinction, yet the mechanisms driving the regional epizootic are not well understood. Here, we developed reef-scale parameterizations of disease spread using model sites in the lower Florida Keys, developed extensive metacommunity habitat maps for the US Caribbean, and then …
Predictors Of Caregiver Burden Among The Caregivers Of Bedridden Patients In Muscat, Oman, Rawan Al Abdulsalam, Hajer Al Shaaibi, Manar Al Sanaa Al Zeedi, Rahma Al Hadhrami
Predictors Of Caregiver Burden Among The Caregivers Of Bedridden Patients In Muscat, Oman, Rawan Al Abdulsalam, Hajer Al Shaaibi, Manar Al Sanaa Al Zeedi, Rahma Al Hadhrami
Sultan Qaboos University Medical Journal
Objectives: Caring for bedridden patients is physically and emotionally demanding, often resulting in significant caregiver burden. This study aimed to assess caregiver burden and associated factors among caregivers of adult bedridden patients in Muscat, Oman. Methods: This cross-sectional study was conducted from January 2024 to February 2025 among caregivers of adult bedridden patients registered to get community services in Muscat Governorate and provided care for more than 1 month. Data were collected using the 12-item Zarit Burden Interview and the Katz Index of Independence in Activities of Daily Living. Results: A total of 200 caregivers participated; 66% were female, with …
Effect Of Remineralization And Resin Infiltration On Microhardness, Mineral Content And Cervical Leakage Of Restored Demineralized Enamel., Caroline Maged Massieh, Sarah Adel Botros
Effect Of Remineralization And Resin Infiltration On Microhardness, Mineral Content And Cervical Leakage Of Restored Demineralized Enamel., Caroline Maged Massieh, Sarah Adel Botros
Dentistry
Purpose: To evaluate the effect of remineralization and resin infiltration on microhardness, mineral content and microleakage in artificially-induced cervical enamel lesions. Materials and Methods: 50 human central incisors were assigned to 5 study groups (n=10) according to different surface intervention: Group 1: Positive Control (sound teeth not subjected to demineralization); Group 2: Negative Control (teeth subjected to demineralization); Group 3: CPP-ACP paste (remineralization of demineralized lesions with CPP-ACP, Tooth Mousse, GC); Group 4: HAp toothpaste (remineralization of demineralized lesions subjected with HAp, Herbadent Remin); Group 5: Resin infiltration (resin infiltration of demineralized lesions with ICON, DMG). Microhardness (MH) was evaluated …
Novel Repurposing Of Empagliflozin-Loaded Buccal Composite (Chitosan/Silk Fibroin/Poly(Lactic Acid)) Nanofibers For Alzheimer’S Disease Management Via Modulation Of Aβ–Ager–P-Tau Pathway, Samar A. Salim
Nanotechnology Research Centre
Background/Objectives: Empagliflozin (EMPA) was repurposed for Alzheimer’s disease (AD) treatment via buccal delivery, exploiting novel nanofibers (NFs) integrating chitosan (Cs), silk fibroin (Fb), and poly(lactic acid) (PLA). Methods: EMPA-loaded Cs/Fb/PLA NFs were electrospun in different formulations to optimize the formulation parameters. The optimized formulation was then investigated for its enhanced in vivo effect. Results: Optimized nanofiber diameters ranged from 459 ± 173 to 668 ± 148 nm, possessing bead-free morphology confirmed by SEM and satisfactory mechanical properties. EMPA was successfully well-dispersed in the polymer matrix as evidenced by FTIR, XRD, and drug content. The optimized NFs displayed a hydrophilic surface …
School Social Workers’ Perceptions Of The Effectiveness Of The Strategies Used To Reduce The Dropout Rates Of African American High School Male Students, Tawanda Mclaurin
School Social Workers’ Perceptions Of The Effectiveness Of The Strategies Used To Reduce The Dropout Rates Of African American High School Male Students, Tawanda Mclaurin
Walden Dissertations and Doctoral Studies
The problem investigated in this study was that approximately 34% of African American male students had dropped out of high school in an urban public school district in the Northern United States. Grounded in Bronfenbrenner’s ecological systems theory, the purpose of this basic qualitative study was to explore school social workers’ perceptions of the effectiveness of strategies used to reduce dropout rates among African American male high school students. Purposive sampling was used to recruit 10 school social workers from one urban public school district who worked with African American male students at risk of dropping out. Data was collected …
A Phenomenological Exploration Of Lgbtq+ High School Graduates’ Perspectives On Lgbtq+-Related Legislation, Thomas James Foley
A Phenomenological Exploration Of Lgbtq+ High School Graduates’ Perspectives On Lgbtq+-Related Legislation, Thomas James Foley
Walden Dissertations and Doctoral Studies
Lesbian, gay, bisexual, transgender, queer, and questioning (LGBTQ+) students’ social, emotional, and academic experiences and outcomes are not on par with their non-LGBTQ+ peers. Understanding how LGBTQ+ young adults experienced high school in a state with LGBTQ+-affirmative education legislation provides insight for counselors and educators to identify policies and practices that support positive outcomes for LGBTQ+ students. This qualitative phenomenological study explored how LGBTQ+-identifying high school graduates made meaning of their experiences in school as they related to LGBTQ+-affirmative education legislation. Interpretive phenomenological analysis (IPA) was used for the research methodology and data analysis process. Results included four themes: (a) …
What’S My Name? Experiences Of Individuals With Traditional Hawaiian Names, Natalya N. Spotkaeff
What’S My Name? Experiences Of Individuals With Traditional Hawaiian Names, Natalya N. Spotkaeff
Walden Dissertations and Doctoral Studies
There is no systematic process of orienting non-Hawaiian educators to Hawaiian culture, as evidenced by name mispronunciation. The purpose of this phenomenological study was to explore the experiences of individuals with traditional Hawaiian first names in a classroom environment. Critical race theory (CRT), especially the concept of microaggressions, was used as the framework for the study. Two research questions guided the study: What are the adult lived experiences with traditional Hawaiian first names encountered in academic settings during childhood? How do adults with traditional Hawaiian first names describe their experiences of race in the classroom? Semistructured interviews were conducted with …
Fibrinogen-Associated Plasma Metabolites And Implications For Coagulation, Inflammation, And Vascular Diseases, Jayna C Nicholas, Taryn Alkis, Joshua C Bis, Eric Boerwinkle, Jennifer A Brody, Clary B Clish, Paul S De Vries, Yan Gao, Robert E Gerzsten, Xiuqing Guo, Andrew D Johnson, Martin G Larson, Rozenn N Lemaitre, Bruce M Psaty, Vasan Ramachandran, Alexander P Reiner, Stephen S Rich, Benjamin Rodriguez, Jian Rong, Jerome I Rotter, Jeanette Simino, Nicholas L Smith, James Wilson, Jie Yao, Alanna C Morrison, Bing Yu, Laura M Raffield
Fibrinogen-Associated Plasma Metabolites And Implications For Coagulation, Inflammation, And Vascular Diseases, Jayna C Nicholas, Taryn Alkis, Joshua C Bis, Eric Boerwinkle, Jennifer A Brody, Clary B Clish, Paul S De Vries, Yan Gao, Robert E Gerzsten, Xiuqing Guo, Andrew D Johnson, Martin G Larson, Rozenn N Lemaitre, Bruce M Psaty, Vasan Ramachandran, Alexander P Reiner, Stephen S Rich, Benjamin Rodriguez, Jian Rong, Jerome I Rotter, Jeanette Simino, Nicholas L Smith, James Wilson, Jie Yao, Alanna C Morrison, Bing Yu, Laura M Raffield
Faculty, Staff and Student Publications
Background: Fibrinogen is a critical coagulation factor that plays an essential role in thrombosis and is elevated in individuals with chronic inflammation. Here, we used fibrinogen as a representative quantitative measure of pro-coagulant risk and evaluated metabolites associated with fibrinogen levels through non-targeted plasma metabolomic profiling (Broad and Metabolon platforms).
Methods: Our analysis included 10,533 individuals across six U.S. based cohorts representing diverse population groups. The cross-sectional relationship between each of 789 tested metabolites and plasma fibrinogen concentration was assessed with adjustment for relevant covariates such as age, sex, body mass index, and circulating lipoprotein levels.
Results: Meta-analysis of per-cohort …
Biogeochemical Cycling Of Dissolved Zinc And Zinc Isotopes In The Arctic Ocean, Elise Langer, Dylan J. Halbeisen, Ruifeng Zhang, Seth G. John, Tim M. Conway
Biogeochemical Cycling Of Dissolved Zinc And Zinc Isotopes In The Arctic Ocean, Elise Langer, Dylan J. Halbeisen, Ruifeng Zhang, Seth G. John, Tim M. Conway
Making Waves REU
- Dissolved Zinc (dZn) is an essential micronutrient that supports primary productivity in the ocean (Morel & Price, 2003).
- Dissolved zinc isotope ratios (δ⁶⁶Zn) help us understand the sources, sinks, and internal cycling of dZn (Bermin et al. 2006; Conway and John, 2014, Horner et al. 2021).
- The background deep ocean has a largely homogenous δ⁶⁶Zn composition of +0.45‰ (Conway and John, 2014), thus deviations away from +0.45±0.05‰ suggest dZn input, loss, or alteration (Fig. 1).
- We hypothesize that margin sediments and freshwater input deliver isotopically light dZn to the coastal Arctic (Jensen et al. 2019).
- Near the North Pole, We …
End Point–Based Threshold For The Ambulatory Arterial Stiffness Index, Yi-Bang Cheng, De-Wei An, Dong-Yan Zhang, Yu-Ling Yu, Jesus D. Melgarejo, José Boggia, Dries S. Martens, Tine W. Hansen, Kei Asayama, Gladys E. Maestre
End Point–Based Threshold For The Ambulatory Arterial Stiffness Index, Yi-Bang Cheng, De-Wei An, Dong-Yan Zhang, Yu-Ling Yu, Jesus D. Melgarejo, José Boggia, Dries S. Martens, Tine W. Hansen, Kei Asayama, Gladys E. Maestre
School of Medicine Publications
Background: The ambulatory arterial stiffness index (AASI) is increasingly used in clinical research and practice. This individual-participant meta-analysis aims to consolidate the prognostic accuracy of AASI in the general population and to derive an end point-based AASI risk threshold.
Methods: In 12 558 individuals enrolled in 14 population studies (48.8% women; mean age, 59.3 years), AASI was derived by regressing 24-hour diastolic on systolic blood pressure (mm Hg/mm Hg). Using Cox regression, the risk-carrying AASI threshold was established by examining stepwise increasing AASI levels and by determining the AASI level, yielding a 10-year risk similar to an office systolic pressure …
Gh Alters Lymphatic Vessels In Female Mice And Stat5 Phosphorylation In Human Lymphatic Endothelial Cells, Christopher Walsh, Emily Scott, Elise Wagner, Jerome Walsh, Shashank Reddy, Arshad Ahmad, Reetobrata Basu, Eva Sevick-Muraca, Rich Brody, Uday Sandbhor, Sebastian Neggers, John J Kopchick
Gh Alters Lymphatic Vessels In Female Mice And Stat5 Phosphorylation In Human Lymphatic Endothelial Cells, Christopher Walsh, Emily Scott, Elise Wagner, Jerome Walsh, Shashank Reddy, Arshad Ahmad, Reetobrata Basu, Eva Sevick-Muraca, Rich Brody, Uday Sandbhor, Sebastian Neggers, John J Kopchick
The Brown Foundation: Institute of Molecular Medicine
Disruption of lymphatic function underlies a broad spectrum of inflammatory and metabolic disorders, yet the hormonal pathways that regulate lymphatic biology remain poorly defined. GH, which is implicated in similar disease states, has an unclear role in lymphatic homeostasis. To address this gap, we investigated how chronic alterations in GH signaling alter lymphatic structure and function. Using transgenic mouse lines with increased, decreased, or absent GH action, we quantified the effect of GH on lymphatic pumping rate and lymphangiogenic remodeling during wound healing using near-infrared fluorescent imaging. We also measured markers of lymphatic endothelial cells using Western blot and immunohistochemistry …
Utilizing Machine Learning Techniques For Computer-Aided Covid-19 Screening Based On Clinical Data, Honglun Xu, Andrews T. Anum, Michael Pokojovy, Sreenath Chalil Madathil, Yuxin Wen, Md. Fashiar Rahman, Tzu-Liang Bill Tseng, Scott Moen, Eric Walser
Utilizing Machine Learning Techniques For Computer-Aided Covid-19 Screening Based On Clinical Data, Honglun Xu, Andrews T. Anum, Michael Pokojovy, Sreenath Chalil Madathil, Yuxin Wen, Md. Fashiar Rahman, Tzu-Liang Bill Tseng, Scott Moen, Eric Walser
Engineering Faculty Articles and Research
The COVID-19 pandemic has highlighted the importance of rapid clinical decision-making to facilitate the efficient usage of healthcare resources. Over the past decade, machine learning (ML) has caused a tectonic shift in healthcare, empowering data-driven prediction and decision-making. Recent research demonstrates how ML was used to respond to the COVID-19 pandemic. This paper puts forth new computer-aided COVID-19 disease screening techniques using six classes of ML algorithms (including penalized logistic regression, random forest, artificial neural networks, and support vector machines) and evaluates their performance when applied to a real-world clinical dataset containing patients’ demographic information and vital indices (such as …
Defining Rna Oligonucleotides That Reverse Deleterious Phase Transitions Of Rna-Binding Proteins With Prion-Like Domains., Lin Guo, Jacob Mann, Jocelyn Mauna, Katie Copley, Hejia Wang, Jack Rubien, Cristian Bergmann, Jenny Carey, Jessica Merjane, Marilyn Ngo, Jiazhen Xu, Hana Odeh, Jiabei Lin, Bo Lim Lee, Laura Ganser, Emma Robinson, Kevin Kim, Anastasia Murthy, Tapas Paul, Bede Portz, Amanda Gleixner, Zamia Diaz, Ashleigh Smirnov, George Padilla, Ellen Lavorando, Carolann Espy, Yulei Shang, Eric Huang, Alessandra Chesi, Nicolas Fawzi, Sua Myong, Christopher Donnelly, James Shorter
Defining Rna Oligonucleotides That Reverse Deleterious Phase Transitions Of Rna-Binding Proteins With Prion-Like Domains., Lin Guo, Jacob Mann, Jocelyn Mauna, Katie Copley, Hejia Wang, Jack Rubien, Cristian Bergmann, Jenny Carey, Jessica Merjane, Marilyn Ngo, Jiazhen Xu, Hana Odeh, Jiabei Lin, Bo Lim Lee, Laura Ganser, Emma Robinson, Kevin Kim, Anastasia Murthy, Tapas Paul, Bede Portz, Amanda Gleixner, Zamia Diaz, Ashleigh Smirnov, George Padilla, Ellen Lavorando, Carolann Espy, Yulei Shang, Eric Huang, Alessandra Chesi, Nicolas Fawzi, Sua Myong, Christopher Donnelly, James Shorter
Department of Biochemistry and Molecular Biology Faculty Papers
RNA-binding proteins (RBPs) with prion-like domains (PrLDs), such as FUS and TDP-43, condense into functional liquids, which can transform into pathological fibrils that underpin fatal neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD). Here, we define short RNAs that prevent FUS fibrillization by promoting liquid phases and distinct short RNAs that prevent and reverse FUS condensation and fibrillization. These activities require interactions with multiple RNA-binding domains of FUS and are encoded by RNA sequence, length, and structure. We define a short RNA that dissolves cytoplasmic FUS aggregates, restores nuclear FUS, and mitigates FUS toxicity in optogenetic models and ALS …
Longitudinal Observation Of Children With Achondroplasia: Findings From A Global Natural History Study (Achieve), Ciara Mcdonnell, Hanne Buciek Hove, Melita Irving, Klane K White, Cesar G Fontecha, Janet M Legare, Wolfgang Högler, Daniel G Hoernschemeyer, Dirk Schnabel, Sheila Unger, Carlos Alberto Bacino, Paul Hofman, Yongguo Yu, Huamei Ma, Chunxiu Gong, Xiaoping Luo, T Andrew Burrow, Geneviève Baujat, Stefano Mora, Melissa Fiscaletti, Carol Zhao, Michael A Makara, Aimee D Shu, Ravi Savarirayan
Longitudinal Observation Of Children With Achondroplasia: Findings From A Global Natural History Study (Achieve), Ciara Mcdonnell, Hanne Buciek Hove, Melita Irving, Klane K White, Cesar G Fontecha, Janet M Legare, Wolfgang Högler, Daniel G Hoernschemeyer, Dirk Schnabel, Sheila Unger, Carlos Alberto Bacino, Paul Hofman, Yongguo Yu, Huamei Ma, Chunxiu Gong, Xiaoping Luo, T Andrew Burrow, Geneviève Baujat, Stefano Mora, Melissa Fiscaletti, Carol Zhao, Michael A Makara, Aimee D Shu, Ravi Savarirayan
Faculty, Staff and Students Publications
Introduction: The ACHieve study assessed growth velocity, body proportionality, and clinical events in children with achondroplasia not receiving growth-promoting therapy.
Methods: ACHieve was a global, longitudinal, prospective, observational study. Children ≤8 years old with achondroplasia were enrolled and evaluated every 6 months for anthropometric parameters and clinical events.
Results: ACHieve enrolled 259 children in 15 countries, including 83 from China. Median follow-up was 21 months; median age of diagnosis was approximately 52 weeks in China and 2 weeks elsewhere. Growth parameters were similar regardless of region. Mean annualized growth velocity was 9.3 cm/year for males and 10.4 cm/year for females …
Multi-Institutional Normal Tissue Complication Probability (Ntcp) Prediction Model For Mandibular Osteoradionecrosis: Results From The Predmorn Study, Laia Humbert-Vidan, Christian R Hansen, Steven Petit, Carles Muñoz-Montplet, Katrina Hueniken, Abdallah S R Mohamed, Deborah P Saunders, Vinod Patel, Gerda M Verduijn, Wilma D Heemsbergen, Arjen Van Der Schaaf, Max Witjes, Suzanne P M De Vette, Mohammad Moharrami, Abdul A Khan, Jordi Marruecos Querol, Irene Oliveras Cancio, Mike Oliver, Peter Reich, Stacey A Santi, Andrew G Pearce, Stephen Y Lai, Andrew P King, Ali Hosni, Andrew J Hope, Erin E Watson, Johannes A Langendijk, Jørgen Johansen, Amy C Moreno, Clifton D Fuller, Lisanne V Van Dijk, Teresa Guerrero Urbano
Multi-Institutional Normal Tissue Complication Probability (Ntcp) Prediction Model For Mandibular Osteoradionecrosis: Results From The Predmorn Study, Laia Humbert-Vidan, Christian R Hansen, Steven Petit, Carles Muñoz-Montplet, Katrina Hueniken, Abdallah S R Mohamed, Deborah P Saunders, Vinod Patel, Gerda M Verduijn, Wilma D Heemsbergen, Arjen Van Der Schaaf, Max Witjes, Suzanne P M De Vette, Mohammad Moharrami, Abdul A Khan, Jordi Marruecos Querol, Irene Oliveras Cancio, Mike Oliver, Peter Reich, Stacey A Santi, Andrew G Pearce, Stephen Y Lai, Andrew P King, Ali Hosni, Andrew J Hope, Erin E Watson, Johannes A Langendijk, Jørgen Johansen, Amy C Moreno, Clifton D Fuller, Lisanne V Van Dijk, Teresa Guerrero Urbano
Faculty, Staff and Student Publications
Purpose: Mandibular osteoradionecrosis (ORN) is a severe late complication affecting patients with head and neck cancer (HNC) treated with radiation therapy (RT) that significantly impacts patients' quality of life and can require costly interventions. Although radiation dose is a key factor, other clinical and demographic risk factors also influence ORN development. Previous predictive models have primarily been single-institutional, limiting their generalizability. In this first analysis from the PREDMORN Consortium, we have aimed to reproduce existing statistical association and modeling analyses on the largest and most diverse mandibular ORN cohort worldwide to allow comparison with previous studies.
Methods and materials: This …
Combinatorial Synthesis Of Protein-Polymer Conjugates By Post-Polymerization Modification Of Poly(Pentafluorophenyl Acrylate)S, Emily W. Kish, Thatcher M. Lee, Alexis M. Ziemba, Ama Boamah, Bianca Figueroa, Margherita Piccardi, Carey E. Dougan, Sarah J. Moore, Maren E. Buck
Combinatorial Synthesis Of Protein-Polymer Conjugates By Post-Polymerization Modification Of Poly(Pentafluorophenyl Acrylate)S, Emily W. Kish, Thatcher M. Lee, Alexis M. Ziemba, Ama Boamah, Bianca Figueroa, Margherita Piccardi, Carey E. Dougan, Sarah J. Moore, Maren E. Buck
Chemistry: Faculty Publications
Combinatorial methods for preparing polymeric biomaterials enable the rapid identification of materials useful for many applications in science, medicine, and engineering. In the work described here, we demonstrate that side-chain reactive polymers can be used as templates for the rapid preparation of a small library of diversely functionalized protein–polymer conjugates. The activated ester polymer poly(pentafluorophenyl acrylate) (PPFPA) was modified postpolymerization with substoichiometric equivalents of three hydrophilic primary amines to yield a library of amphiphilic, side-chain reactive copolymers. These copolymers were then conjugated to two receptor-targeting proteins, holotransferrin (hTF) and an engineered fibronectin-based protein (Fn3), through amine-activated ester coupling. We investigated …
Characterization Of Novel Sigma Receptor Ligands Derived From Multicomponent Reactions As Efficacious Treatments For Neuropathic Pain, Ryosuke Shinouchi, Bengisu Turgutalp, Rohini S Ople, Shainnel O Eans, Ashai K Williams, Haylee R Hammond, Andras Varadi, Rebecca Notis Dardashti, Susruta Majumdar, Jay P Mclaughlin
Characterization Of Novel Sigma Receptor Ligands Derived From Multicomponent Reactions As Efficacious Treatments For Neuropathic Pain, Ryosuke Shinouchi, Bengisu Turgutalp, Rohini S Ople, Shainnel O Eans, Ashai K Williams, Haylee R Hammond, Andras Varadi, Rebecca Notis Dardashti, Susruta Majumdar, Jay P Mclaughlin
2020-Current year OA Pubs
No abstract provided.
Analysis Of Lake Toba Ecoliteracy In High School Students, Jesika Aurelia Sianipar, B Manurung, Martina Asiati Napitupulu, Abdul Hakim Daulae
Analysis Of Lake Toba Ecoliteracy In High School Students, Jesika Aurelia Sianipar, B Manurung, Martina Asiati Napitupulu, Abdul Hakim Daulae
Jurnal Pendidikan Sains
The Lake Toba ecosystem is currently experiencing increasingly worsening quality degradation, so that instilling environmental awareness through ecoliteracy has become urgent in the world of education. This study aims to measure the ecoliteracy abilities of students at High School 1 Ajibata and High School 2 Balige by reviewing three main aspects: cognitive, affective, and behavioral. Additionally, it will analyze the differences in ecoliteracy levels between the two schools. The type of research used is ex post facto with a quantitative approach. Data were collected through test instruments for the cognitive aspect and questionnaires for the affective and behavioral aspects. The …