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The Influence Of Bapineuzumab And Semagacestat On Rapid Progressors: A Retrospective Cohort Study, Kristofer Harris, Madison Shyer, Dulin Wang, Elizabeth He, Matias Cattani, Catherine Zhang, Christine M Farrell, Xiaoqian Jiang, Yejin Kim, Paul E Schulz

Faculty, Staff and Student Publications

Background: A subset of Alzheimer's disease patients progresses much more rapidly than average. These rapid progressors exhibit accelerated cognitive and functional decline. Potential differences in Alzheimer's biomarkers for rapid progressors and their responses to disease-modifying treatments remain poorly understood, with previous clinical trials and studies producing limited biomarker data and inconsistent results.

Objectives: Examine differences in rapid progressor versus non-rapid progressor outcomes in two AD treatment trials (bapineuzumab and semagacestat) and investigate cognitive and biomarker progression in the placebo groups.

Design: Retrospective cohort study.

Setting: Four randomized, double-blind, phase 3 clinical trials from the Center for Global Clinical Research Data …

Ionic Mechanisms Of Two-Pore Channel Regulation Of Vesicle Trafficking, Heng Zhang, Michael X Zhu

Faculty, Staff and Student Publications

The endolysosomal system plays a pivotal role in cellular function. Before reaching lysosomes for degradation, the endocytosed cargoes are sorted at various stages of endosomal trafficking for recycling and/or rerouting. The proper execution of these processes depends on tightly regulated ion fluxes across endolysosomal membranes. Recent studies have demonstrated the importance of two-pore channels (TPCs), including TPC1 and TPC2, in endolysosomal trafficking. These channels are expressed in the membranes of distinct populations of endosomes and lysosomes, where they respond to nicotinic acid adenine dinucleotide phosphate (NAADP) and phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2] to conduct Ca2+ and Na+ release from these acidic organelles. …

Simulated Complex Cells Contribute To Object Recognition Through Representational Untangling, Mitchell B Slapik, Harel Z Shouval

Faculty, Staff and Student Publications

The visual system performs a remarkable feat: it takes complex retinal activation patterns and decodes them for object recognition. This operation, termed "representational untangling," organizes neural representations by clustering similar objects together while separating different categories of objects. While representational untangling is usually associated with higher-order visual areas like the inferior temporal cortex, it remains unclear how the early visual system contributes to this process-whether through highly selective neurons or high-dimensional population codes. This article investigates how a computational model of early vision contributes to representational untangling. Using a computational visual hierarchy and two different data sets consisting of numerals …

Doctoral Students’ Perceived Academic Research Reading Ability: A Mixed-Methods Study, Ryan Glaman

International Journal of Teaching and Learning in Higher Education

Empirical research is useful for informing educational policy and practice. However, doctoral students often struggle with reading and evaluating empirical research papers. The present study examined doctoral students’ perceptions of their ability to read and evaluate empirical research articles, both before and after an educational research methods course, as well as which course components students perceived as most impacting their ability to read and evaluate research articles. The study used a convergent mixed methods design, involving pre- and post-course survey data. Results indicated students felt they improved in their experience levels, comfort levels, interpretation ability, and evaluation ability regarding reading …

Engaging Asl-English Interpreting Undergraduates In Research: A Model For Student Engagement And Faculty Productivity, Kimberly J. Hale, Valerie Freeman

Journal of Interpretation

Engaging undergraduate ASL-English interpreting students in research yields multiple benefits beyond enhancing faculty scholarly productivity. In this innovative practices article, we first summarize scholarly literature showing that including undergraduates in research experiences supports development of career-readiness skills while simultaneously building the pipeline of future faculty. We then discuss the benefits of undergraduate research experiences and argue that research activities can be integrated throughout an interpreter education program curriculum. Using a detailed description of a course-based undergraduate research experience (CURE) and course-embedded project examples, we demonstrate how structured research experiences can be integrated into programs without creating additional burden for faculty …

A Comparison Of Biological Therapies Vs Traditional Immunosuppressant In The Management Of Inflammatory Bowel Diseases: A Narrative Review, Umme Farwah Tahir Dr, Sadaf Noureen, Fnu Partab, Muhammad Waqas Afzal, Maham Afzal, Asad Mehmood, Fatima Afzal, Kaynat Hasan, Fnu Sameeha, Seerat Riaz, Sumyya Tariq, Abida Perveen

Journal of Community Hospital Internal Medicine Perspectives

Inflammatory bowel disease (IBD), encompassing Crohn’s disease and ulcerative colitis, is a chronic immune-mediated condition requiring long-term management. Traditional immunosuppressants, such as corticosteroids, thiopurines, and methotrexate, have been widely used but are associated with broad immunosuppressive effects and significant adverse events. The advent of biological therapies, including tumor necrosis factor (TNF) inhibitors, integrin inhibitors, and interleukin (IL)-12/23 inhibitors, has revolutionized IBD treatment by offering targeted immune modulation. Biologics have demonstrated superior efficacy in achieving and maintaining remission compared to traditional immunosuppressants, particularly in moderate to severe IBD. They provide targeted immune suppression, reducing systemic side effects, but are associated with …

Statin Induced New-Onset Diabetes Mellitus A Narrative Review, Jasvin K Manha, Sumanth Kumar Bandaru

Journal of Community Hospital Internal Medicine Perspectives

Statins are widely used to lower LDL cholesterol and prevent cardiovascular disease. Although generally safe, there is increasing evidence that they may increase the risk of new-onset diabetes mellitus (NODM). Recent studies show a modest but consistent rise in diabetes risk associated with statin use, especially among individuals with prediabetes, obesity, or other metabolic risk factors. High-intensity statins like atorvastatin and rosuvastatin carry a greater risk compared to agents such as pravastatin or pitavastatin. Proposed mechanisms include increased insulin resistance, impaired insulin secretion, and changes in hepatic glucose production. Despite the diabetes risk associated with statins, their well-established cardiovascular benefits …

Short Term Outcomes And Resource Utilization In Patients Admitted For Infective Endocarditis Who Develop Pericardial Effusion: A Retrospective Cohort Study, Nameer Ascandar, Sajog Kansakar, Waqas Qureshi, Aakash Patel, Ahmed O. Farooq, Brett Milford, Suman Pasupuleti, Eduardo J. Lazaro

Journal of Community Hospital Internal Medicine Perspectives

Background: Pericardial effusion (PCE) development in the context of infective endocarditis (IE) may negatively impact clinical outcomes leading to intense resource utilization. Limited contemporary studies exist that examine clinical outcomes, resource utilization and readmission rates in patients admitted for IE who develop PCE.

Methods: We utilized the Nationwide Readmissions Database years 2016-2022 to tabulate all adult admissions for IE. We compared clinical outcomes in patients who developed PCE to those who did not. Survey weighted logistic and linear regression analysis was performed to predict in-hospital mortality, clinical outcomes, costs, and 30-day non-elective readmission in association with PCE.

Results: Of an …

Teachers’ Perceptions Towards Disruptive Behaviours Among Students In Public Secondary Schools In Tanzania, Jonas Kinanda

Tanzania Journal of Sociology

Disruptive behaviours among secondary school students adversely affect students, teachers, parents and community members. This study explores teachers’ perceptions towards disruptive behaviours among students in public secondary schools in Tanzania. This qualitative study involved 50 teachers selected from four public secondary schools from two councils, namely Mwanza City and Ukerewe District, both found in Mwanza Region, Tanzania. Data collection was done through interviews, focus group discussions, and document reviews. The analysis was thematic and MAXQDA. The findings showed that teachers perceived students’ disruptive behaviours as problematic to the teachers, peers, school administrators, parents, and the community at large. This is …

Capitalist Social Relations And The Environment: A Hyena—Baby Gazelle Acquaintance, Nelson Mwesiga Ishengoma

Tanzania Journal of Sociology

Despite playing a critical role in the survival of living beings, several empirical findings all around the world suggest that the planet Earth is now in a perilous state. Whilst acknowledging the influence of several superficial humanistic factors upon which the conventional discourses on the current environmental concerns have long been affixed, this analytical paper contends that such aspects are deficient in comprehending and remedying the problem. Contrarily, attempts to identify the underlying causes and cures of the environmental problem should recognise the modus vivendi of the prevailing capitalistic social relations, which serve as the basis for existing exploitative and …

Nssf Social Health Insurance Benefit (Shib) And Health Care Services: Accessibility And Availability In Tanzania, Leah Natujwa Omari

Tanzania Journal of Sociology

This study is about “Social Health Insurance and accessibility of health care services through National Social Security Fund (NSSF) Health Insurance service in Kinondoni Municipality. The focus of this study was on the ease of accessing health services using the NSSF health insurance, and the beneficiaries’ awareness level since people knew about NHIF and ICHF only. The objective of the study is to examine the accessibility of Social Health Insurance Benefits on health care service to people at Kinondoni Municipality. The study used a qualitative research approach to gather and analyze data from informants. In-depth interview was used to capture …

From De-Emphasizing Public Health And Social Measures For Covid-19 To Vaccine Acceptance: An Analysis Of Two Tanzanian Administration’S Responses To Covid-19, Simon Mutebi

Tanzania Journal of Sociology

Recent global public health literature on politics and pandemics has explored the diversity of African political leaders’ responses to COVID-19. In this article, analysis is done of two Tanzanian administrations’ responses to COVID-19 to show how they departed from each other. For instance, the late President John Magufuli’s administration promoted ‘Afrocentric’ medical knowledge, endogenous initiatives, and spiritual prowess while de-emphasizing ‘Western’ biomedical and public health measures to prevent the spread of COVID-19. His successor, President Samia Suluhu Hassan’s administration, however, favoured and promoted public health and social interventions and authorized the importation and use of COVID-19 vaccines in Tanzania. Drawing …

Role Of Social Workers In Identifying Challenges And Developing Skills In Children With Learning Disabilities, Trichal Mamta

Tanzania Journal of Sociology

Social work values, ethics, and abilities are crucial for ensuring tailored care and support practice and advocacy based on human rights. For Children with learning disabilities, it is beneficial. The paper focuses on social work skills useful in helping kids with learning disabilities. It describes the main disagreements in the area, such as those over policy and practice. Additionally, it is asserted that social workers are well equipped to do research and engage in clinical treatment that advances social justice and full and meaningful involvement in society. The study's objective is to identify social workers varied supporting and rehabilitative roles …

The Need Of Online Counselling To Enhance Mental Health Among Students In Higher Learning Institutions In Tanzania, Bernadetha Gabriel Rushahu

Tanzania Journal of Sociology

This study aimed to explore the need of online counselling to enhance mental health among students in higher learning institutions. The study employed a qualitative research approach in which 40 participants were involved. These were purposefully selected from two higher learning institutions in Tanzania - 30 were students and 10 were counsellors. In-depth interviews and Focus Group Discussion were used to collect data from the respondents. The findings revealed that through online counselling, it is easy to access psychosocial therapy, maintain privacy, conduct time/cost-friendly therapy, access services, allow freedom of expression as well as allow easy feedback and follow-up. Also, …

Exploration Of The Child Domestic Workers’ Lived Experiences In Dar Es Salaam, Tanzania, Magolanga Shagembe, Thomas Ndaluka

Tanzania Journal of Sociology

This qualitative study, based on a phenomenological design, explored the lived experiences of child domestic workers aged 15 to 18 years in Dar es Salaam, Tanzania. Children in this age group are above the national and international legal minimum age for admission into light work. The findings of our study indicated that although domestic work is perceived by the child domestic workers as a method for impoverished children between the ages of 15 and 18 to earn money, get experience, and learn new life skills, it also entails loneliness, challenges in assimilating into an unfamiliar social context, and child sexual …

Even A Scorpion Sting Hurts Just As Much: A Sobering Look At Men As Victims Of Intimate Partner Abuse And Violence, Nelson Mwesiga Ishengoma

Tanzania Journal of Sociology

The subject of intimate violence and abuse has piqued the interest of different groups of people, including psychologists, scholars, and human rights activists over the past 45 years. Even though the epidemiological literature has consistently shown that at least one out of every three people who experience intimate partner violence is a male partner, current initiatives have chosen to ignore this fact. Instead, the phenomenon has been described by most of its advocates as a gender-cockeyed social issue, with a man penned in an “offender” position and a woman in that of a “helpless victim”. Consequently, the exploited man and …

Side Effects Of The Coexistence Of Tradition Medicine With Biomedicine In Primary Health Service Delivery In Rural Areas Of Tanzania, Matrona Kabyemela

Tanzania Journal of Sociology

It is approximated that 60-80 per cent of Tanzanians use Traditional Medicine (TM) as their primary source of health services alongside biomedical services. However, there is little information on the side effects of the co-existence of TM with biomedical system to primary health services delivery in Tanzania. By using Helmke and Levitsky’s Model of co-existence of formal and informal institutions in comparative politics, this article argues that the coexistence of TM and biomedicine undermine the delivery of primary health services in rural areas of Tanzania due to abrupt stoppage of using biomedicine among users, concurrent use of TM and biomedicine …

From De-Emphasizing Public Health And Social Measures For Covid-19 To Vaccine Acceptance: An Analysis Of Two Tanzanian Administration’S Responses To Covid-19, Simon Mutebi

Tanzania Journal of Sociology

Recent global public health literature on politics and pandemics has explored the diversity of African political leaders’ responses to COVID-19. In this article, analysis is done of two Tanzanian administrations’ responses to COVID-19 to show how they departed from each other. For instance, the late President John Magufuli’s administration promoted ‘Afrocentric’ medical knowledge, endogenous initiatives, and spiritual prowess while de-emphasizing ‘Western’ biomedical and public health measures to prevent the spread of COVID-19. His successor, President Samia Suluhu Hassan’s administration, however, favoured and promoted public health and social interventions and authorized the importation and use of COVID-19 vaccines in Tanzania. Drawing …

Role Of Social Workers In Identifying Challenges And Developing Skills In Children With Learning Disabilities, Trichal Mamta

Tanzania Journal of Sociology

Social work values, ethics, and abilities are crucial for ensuring tailored care and support practice and advocacy based on human rights. For Children with learning disabilities, it is beneficial. The paper focuses on social work skills useful in helping kids with learning disabilities. It describes the main disagreements in the area, such as those over policy and practice. Additionally, it is asserted that social workers are well equipped to do research and engage in clinical treatment that advances social justice and full and meaningful involvement in society. The study's objective is to identify social workers varied supporting and rehabilitative roles …

The Need Of Online Counselling To Enhance Mental Health Among Students In Higher Learning Institutions In Tanzania, Bernadetha Gabriel Rushahu

Tanzania Journal of Sociology

This study aimed to explore the need of online counselling to enhance mental health among students in higher learning institutions. The study employed a qualitative research approach in which 40 participants were involved. These were purposefully selected from two higher learning institutions in Tanzania - 30 were students and 10 were counsellors. In-depth interviews and Focus Group Discussion were used to collect data from the respondents. The findings revealed that through online counselling, it is easy to access psychosocial therapy, maintain privacy, conduct time/cost-friendly therapy, access services, allow freedom of expression as well as allow easy feedback and follow-up. Also, …

Even A Scorpion Sting Hurts Just As Much: A Sobering Look At Men As Victims Of Intimate Partner Abuse And Violence, Nelson Mwesiga Ishengoma

Tanzania Journal of Sociology

The subject of intimate violence and abuse has piqued the interest of different groups of people, including psychologists, scholars, and human rights activists over the past 45 years. Even though the epidemiological literature has consistently shown that at least one out of every three people who experience intimate partner violence is a male partner, current initiatives have chosen to ignore this fact. Instead, the phenomenon has been described by most of its advocates as a gender-cockeyed social issue, with a man penned in an “offender” position and a woman in that of a “helpless victim”. Consequently, the exploited man and …

Exploration Of The Child Domestic Workers’ Lived Experiences In Dar Es Salaam, Tanzania, Magolanga Shagembe, Thomas Ndaluka

Tanzania Journal of Sociology

This qualitative study, based on a phenomenological design, explored the lived experiences of child domestic workers aged 15 to 18 years in Dar es Salaam, Tanzania. Children in this age group are above the national and international legal minimum age for admission into light work. The findings of our study indicated that although domestic work is perceived by the child domestic workers as a method for impoverished children between the ages of 15 and 18 to earn money, get experience, and learn new life skills, it also entails loneliness, challenges in assimilating into an unfamiliar social context, and child sexual …

Side Effects Of The Coexistence Of Tradition Medicine With Biomedicine In Primary Health Service Delivery In Rural Areas Of Tanzania, Matrona Kabyemela

Tanzania Journal of Sociology

It is approximated that 60-80 per cent of Tanzanians use Traditional Medicine (TM) as their primary source of health services alongside biomedical services. However, there is little information on the side effects of the co-existence of TM with biomedical system to primary health services delivery in Tanzania. By using Helmke and Levitsky’s Model of co-existence of formal and informal institutions in comparative politics, this article argues that the coexistence of TM and biomedicine undermine the delivery of primary health services in rural areas of Tanzania due to abrupt stoppage of using biomedicine among users, concurrent use of TM and biomedicine …

Intouch Week Of January 19, 2026, New York Medical College

InTouch

• Celebrating a Landmark Oncology Text and Progress in Cancer Care
• SOM Student Aryan Malhotra Sets Research Presentation Records at Neurosurgery Conference
• Love at NYMC
• Student Spotlight: From Athlete to Aspiring Orthopedic Surgeon
• Faculty Spotlight: From Pupil to Professor: Alumni Lighting the Way at NYMC

Pulmonary Obstruction And Age, Not Activity, Associate With Muscle Oxidative Impairment In Smokers With And Without Copd, Alessandra Adami, Fenghai Duan, Robert A. Calmelat, Zeyu Chen, Richard Casaburi, Harry B. Rossiter

Kinesiology Faculty Publications

Background: Low muscle oxidative capacity is an extrapulmonary manifestation of chronic obstructive pulmonary disease (COPD) with unclear aetiology. We sought to characterize locomotor muscle oxidative capacity in never smokers and ever smokers with and without COPD and determine clinical and behavioural features associated with low muscle oxidative capacity.

Methods: Two hundred forty-three adults enrolled in the Muscle Health Study, an observational study ancillary to COPDGene. Gastrocnemius oxidative capacity was measured by near-infrared spectroscopy from the muscle oxygen consumption recovery rate constant (k). Physical activity was measured by accelerometry (vector magnitude units [VMU]/min). Pulmonary assessments included spirometry (FEV1%predicted), diffusing capacity (DLCO) …

Longitudinal Analysis Of Body Weight Reveals Homeostatic And Adaptive Traits Linked To Lifespan In Diversity Outbred Mice., G V Prateek, Zhenghao Chen, Kevin Wright, Andrea Di Francesco, Vladimir Jojic, Gary Churchill, Anil Raj

Faculty Research 2026

Dense temporal measurements of physiological health, using simple and consistent assays, are essential to characterize biological processes associated with aging and evaluate the effectiveness of interventions on these processes. We measured body weight in 960 genetically diverse female mice, every 7-10 days over the full course of their lifespan. We used a state space model to characterize the trajectories of body weight throughout life and derived novel traits capturing the dynamics of body weight, 10 of which were both heritable and associated with lifespan. Genetic mapping of these body weight-derived traits identified 5 genomic loci, none of which were previously …

A Review Of 3d-Printed Medical Devices For Cancer Radiation Therapy., Radiah Pinckney, Santosh Kumar Parupelli, Peter Sandwall, Sha Chang, Salil Desai

Oncology Articles

This review explores the transformative role of three-dimensional (3D) printing in radiation therapy for cancer treatment, emphasizing its potential to deliver patient-specific, cost-effective, and sustainable medical devices. The integration of 3D printing enables rapid fabrication of customized boluses, compensators, immobilization devices, and GRID collimators tailored to individual anatomical and clinical requirements. Comparative analysis reveals that additive manufacturing surpasses conventional machining in design flexibility, lead time reduction, and material efficiency, while offering significant cost savings and recyclability benefits. Case studies demonstrate that 3D-printed GRID collimators achieve comparable dosimetric performance to traditional devices, with peak-to-valley dose ratios optimized for spatially fractionated radiation …

Longitudinal Analysis Of Body Weight Reveals Homeostatic And Adaptive Traits Linked To Lifespan In Diversity Outbred Mice., G V Prateek, Zhenghao Chen, Kevin Wright, Andrea Di Francesco, Vladimir Jojic, Gary Churchill, Anil Raj

Faculty Research 2026

Dense temporal measurements of physiological health, using simple and consistent assays, are essential to characterize biological processes associated with aging and evaluate the effectiveness of interventions on these processes. We measured body weight in 960 genetically diverse female mice, every 7-10 days over the full course of their lifespan. We used a state space model to characterize the trajectories of body weight throughout life and derived novel traits capturing the dynamics of body weight, 10 of which were both heritable and associated with lifespan. Genetic mapping of these body weight-derived traits identified 5 genomic loci, none of which were previously …

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.

The Effects Of Magnesium Glycinate Vs. Magnesium Citrate On The Growth Of Lactobacillus Acidophilus In Simulated Gastrointestinal Conditions, Inaya Siddique

Journal of the South Carolina Academy of Science

No abstract provided.