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Invitations To Stem: Activities For Building Community And Enthusiasm From A First-Year Seminar, Dusty Grundmeier, Shanelle Davis Jan 2026

Invitations To Stem: Activities For Building Community And Enthusiasm From A First-Year Seminar, Dusty Grundmeier, Shanelle Davis

Journal of Humanistic Mathematics

We reflect on and analyze a first-year seminar designed as an invitation to Science, Technology, Engineering, and Mathematics (STEM) fields. We present sample activities designed to develop mathematical and scientific problem-solving skills while also building community and enthusiasm. Through solving mathematical puzzles, project-based learning, and reflective activities, students develop a supportive and welcoming STEM-focused community and identity. Along with sample activities, we share our goals, challenges, and student feedback. Finally, we suggest some guiding principles for designing and choosing problems for similar STEM enrichment activities and seminars.


A Note On Modeling Prejudice, Alan Lockard, Edwin Harcourt Jan 2026

A Note On Modeling Prejudice, Alan Lockard, Edwin Harcourt

Journal of Humanistic Mathematics

We model prejudice in the context of an iterated prisoner’s dilemma tournament. Prejudice here is defined as the inability to distinguish amongst members of an identifiable group. We run a computer simulation where agents of one of two groups with defined strategies are randomly matched against each other. The agents either cooperate with or defect against the agent they are matched with. Our focus is on agents who play an unprejudiced version of the Tit-for-Tat strategy (cooperate with any player in the first encounter, and then apply the same strategy [defect or cooperate] that the opposing player played against them …


Exploring The Dynamics Of Romantic Relationships Through The Lens Of Prem Rog, Umang Jain, Dheeraj Sharma, Pranay Goswami, Kuldeep Malik Jan 2026

Exploring The Dynamics Of Romantic Relationships Through The Lens Of Prem Rog, Umang Jain, Dheeraj Sharma, Pranay Goswami, Kuldeep Malik

Journal of Humanistic Mathematics

Romantic relationships are dynamic events that begin, grow, and frequently remain for a long time in a stagnant or fluctuating state until possibly dissipating. Although they are unquestionably the most significant dynamic events in our lives, dynamic systems theory has only recently included them in its formal framework. Without a mathematical model, it would be impossible to analyze and comprehend the dynamics because, in general, love stories are too brief to allow things to stabilize and are affected by the ups and downs of the surrounding community. In this paper, we set up models made up of four ordinary differential …


The Sled Dog Whisperer, Shawn Hannah Jan 2026

The Sled Dog Whisperer, Shawn Hannah

Fresh Voices: Composition at Cal Poly

No abstract provided.


A Day On The Job With The Cal Poly University Police, Russel Morra Jan 2026

A Day On The Job With The Cal Poly University Police, Russel Morra

Fresh Voices: Composition at Cal Poly

No abstract provided.


Coase, Thaler, And Behavioral Economics: Methodological Considerations Jan 2026

Coase, Thaler, And Behavioral Economics: Methodological Considerations

Journal of Economics and Finance Education

In their experiments to measure the endowment effect in market settings, Kahneman, Knetsch, and Thaler (1990; hereafter KKT) assessed the assumption of zero transaction costs associated with the Coase theorem. Their study recruited a sample of advanced undergraduate economics students who were placed in a market setting using coffee mugs as real-world goods, under conditions in which there were zero transaction costs. Their results suggested that an endowment effect lowered trading volume, which should not have occurred if Coase theorem worked in practice. We reexamine the research design employed by KKT, as well as their study’s statistical analysis and results.


Eugenics And The Carceral State: Progressive-Era Reform & The Creation Of The Modern Criminal Justice System, Laura I. Appleman Jan 2026

Eugenics And The Carceral State: Progressive-Era Reform & The Creation Of The Modern Criminal Justice System, Laura I. Appleman

Missouri Law Review

No abstract provided.


Dual Tyk2/Jak1 Inhibition By Brepocitinib Reprograms Synoviocyte Pathobiology: Mechanistic Insights Into Targeted Therapy For Rheumatoid Arthritis, Umar Saeed, Zahra Zahid Piracha, Andromeda M. Nauli, Surya M. Nauli Jan 2026

Dual Tyk2/Jak1 Inhibition By Brepocitinib Reprograms Synoviocyte Pathobiology: Mechanistic Insights Into Targeted Therapy For Rheumatoid Arthritis, Umar Saeed, Zahra Zahid Piracha, Andromeda M. Nauli, Surya M. Nauli

Pharmacy Faculty Articles and Research

Background:

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovial hyperplasia, persistent inflammation, and joint destruction. Targeted inhibition of intracellular signaling pathways, such as JAK-STAT, has improved RA treatment outcomes, though safety and selectivity remain as concerns. Brepocitinib, a dual TYK2/JAK1 inhibitor, has shown clinical efficacy in the management of autoimmune diseases, yet its mechanistic impact on synoviocytes remains underexplored.

Objectives:

To investigate the molecular and functional effects of brepocitinib on MH7A and RA-FLS synoviocytes, a key effector cell type in RA pathogenesis.

Methods:

MH7A and RA-FLS cells were treated with brepocitinib (0.5 µM, 1 µM, and 5 …


Zoune At Her Nann-Enn's House, Justin Lhérisson, Susan Kalter Jan 2026

Zoune At Her Nann-Enn's House, Justin Lhérisson, Susan Kalter

Undiscovered Americas

Zoune at Her Nann-enn’s House by Justin Lhérisson is a 1906 Haitian novella that examines the social and domestic trials young women face as they come of age. Translated by Susan Kalter, this first-ever English-language edition of the book also provides a rich afterword that critically situates Lhérisson’s story in social and political Haitian contexts and establishes how those particular contexts connect to larger social issues in our present moment. The plot follows a quietly resilient young girl, Zoune, sent from the countryside to live with her godmother in Port-au-Prince. Removed from her biological family, Zoune grows up under the …


Humanity Is Evolving Its Consciousness: The Role Of Archetypal Energies As Guides During An Unfolding Weeding Out And Alignment Process, Carroy U. Ferguson Jan 2026

Humanity Is Evolving Its Consciousness: The Role Of Archetypal Energies As Guides During An Unfolding Weeding Out And Alignment Process, Carroy U. Ferguson

Psychology Faculty Publication Series

Humanity is evolving its consciousness at individual and collective levels.  Given these seemingly tumultuous times, as of this writing (January 2026), to make such a statement may sound like a strange thing to say.  However, I suggest that if you are alive today and if you are reading these words, these are the very times for which you were born—to assist Humanity as it evolves its consciousness with your unique gifts, whatever they may be.  That is, this period of our individual and collective human being-ness may be characterized as an unfolding period of weeding out and alignment with the …


Microplastics In St. John, United States Virgin Islands Sediments: Methodological Approaches And Variability Of Microplastics Concentrations And Accumulation Rates, Henry B. Arbaugh, Sarah C. Gray, Dimitri Deheyn Jan 2026

Microplastics In St. John, United States Virgin Islands Sediments: Methodological Approaches And Variability Of Microplastics Concentrations And Accumulation Rates, Henry B. Arbaugh, Sarah C. Gray, Dimitri Deheyn

Theses

Sediment samples were collected from a near shore and reef site in Coral Bay, St. John, United States Virgin Islands (USVI) from 2007-2016, using tube sediment traps. These samples provide an opportunity to study microplastics (MPs) in an area where no previous MP studies have been performed. Most sedimentary MP studies utilize benthic samples which can only measure MP concentrations (#MP/g or #MP/mL sediment), while sediment traps can provide MP accumulation rates (#MP/cm2/day) as a function of time. However, the methods used for extracting MPs from benthic samples have not been tested using sediment trap samples whose characteristics, …


Evaluation Of Large Language Models As Decision Support Tools For Head And Neck Cancer Management: A Blinded Multidisciplinary Simulation Study, Sholem Hack, Ron J. Karni, Antonino Maniaci, Christopher E. Fundakowski, Luca Castellani, Fabiola Incandela, Remo Accorona, Miguel Mayo-Yanez, Martina Violati, Lorenzo Giannini, Niccolo' Mevio, Alberto Maria Saibene Jan 2026

Evaluation Of Large Language Models As Decision Support Tools For Head And Neck Cancer Management: A Blinded Multidisciplinary Simulation Study, Sholem Hack, Ron J. Karni, Antonino Maniaci, Christopher E. Fundakowski, Luca Castellani, Fabiola Incandela, Remo Accorona, Miguel Mayo-Yanez, Martina Violati, Lorenzo Giannini, Niccolo' Mevio, Alberto Maria Saibene

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

BACKGROUND: The management of head and neck cancer relies on multidisciplinary expertise; however, access to tumor boards remains variable. Large language models (LLMs) may support guideline-based decision-making, although performance in complex oncologic scenarios is not well defined.

METHODS: Fourteen synthetic cases based on real tumor board encounters were evaluated. Five blinded comparator arms produced recommendations: a human expert, Non-RAG-GPT-4, Non-RAG-GPT-5, RAG-GPT-4, and RAG-GPT-5. Eight head and neck oncologic surgeons scored each recommendation for appropriateness, clarity, specificity, and feasibility using 5-point Likert scales. Paired permutation testing and inter-rater reliability were assessed.

RESULTS: LLM outputs showed close alignment with expert recommendations. RAG-based …


Salivary Protein Quantity, Ionic Value, And Protein Movement In Stunted And Non-Stunted Children In Indonesia, Munifah Abdat, Sri Rezeki, Putri N. Zulkifli, Mela R. Adinda, Ardiansyah S. Pawinru, Eka Setyawardana Jan 2026

Salivary Protein Quantity, Ionic Value, And Protein Movement In Stunted And Non-Stunted Children In Indonesia, Munifah Abdat, Sri Rezeki, Putri N. Zulkifli, Mela R. Adinda, Ardiansyah S. Pawinru, Eka Setyawardana

Journal of Dentomaxillofacial Science

Objective: This study aimed to analyze total salivary protein quantity, ionic activity, and protein molecular movement in children with and without stunting.

Material and Method: Saliva samples were collected from 30 children aged 4-6years (15stunted and15 non-stunted). Proteins were extracted using 0.1 M HCI. The total protein quantity was determined using the Bradford assay and Fourier Transform Infrared (FTIR) spectroscopy. Salivary ionic activity (dissolved oxygen, conductivity, and total dissolved solids) and salivary viscosity were measured using an ionic meter and an Ostwald viscometer, respectively. Statistical analyses included independent t-tests, Kruskal-Wallis tests, and Spearman correlation analyses (a=0.05).

Results: Stunted children had …


Thoracic Aorta Calcification And Risk Of All-Cause Mortality And Cardiovascular Outcomes: A Systematic Review And Meta-Analysis, Yasir Salah Jumah Alam, Hussein Nafakhi, Alaa Salah Jumaah, Akeel Abed Yasseen, Zahraa Alaa Salah Alam, Ali Athir Abdulraheem Jan 2026

Thoracic Aorta Calcification And Risk Of All-Cause Mortality And Cardiovascular Outcomes: A Systematic Review And Meta-Analysis, Yasir Salah Jumah Alam, Hussein Nafakhi, Alaa Salah Jumaah, Akeel Abed Yasseen, Zahraa Alaa Salah Alam, Ali Athir Abdulraheem

Sultan Qaboos University Medical Journal

This review aimed to assess thoracic aorta calcification (TAC) as a predictor of all-cause mortality, cardiovascular (CV) morbidity and mortality across various clinical settings using different imaging modalities. Medical databases were systematically searched up to mid-July 2025 for studies linking TAC with mortality and CV outcomes. A total of 43 studies involving 176,738 participants were included. TAC was associated with higher risks of all-cause mortality (hazard ratio [HR] = 1.614), CV mortality (HR = 2.130), coronary events (HR = 1.423), major adverse cardiac events (HR = 2.011) and stroke (HR = 1.450. Computed tomography showed the strongest associations (all-cause mortality …


Facial Shape And Craniofacial Anthropometry Associated With Masticatory Muscle Pain: A Clinical Study, Mohammad Gazali, Fuad H. Akbar, Acing H. Mude, Maya Marisa, Muhammad Ruslin Jan 2026

Facial Shape And Craniofacial Anthropometry Associated With Masticatory Muscle Pain: A Clinical Study, Mohammad Gazali, Fuad H. Akbar, Acing H. Mude, Maya Marisa, Muhammad Ruslin

Journal of Dentomaxillofacial Science

Objective: The present study aimed to examine the relationship between facial morphology and cranial anthropometric parameter; with masticatory muscle pain, notably in the masseter and temporalis muscles.

Material and Method: An analytical cross-sectional study was conducted involving 69 adult participants aged 18-50 year. Craniofacial dimensions, including head length, width and height, were measured using standardized anthropometric techniques. Facial shape was classified visually into round, oval or square types. Pain in the masticatory muscles was assessed using standardized palpation protocols based on the diagnostic criteria for temporo-mandibular disorders (TMDs), along with the visual analogue scale and numeric rating scale. Statistical analysis …


Multifunctional Green Wall Systems For Greywater Treatment And Hygrothermal Regulation In Egypt, Laila Ossama Mohamed Elhusseiny Abdelsalam Jan 2026

Multifunctional Green Wall Systems For Greywater Treatment And Hygrothermal Regulation In Egypt, Laila Ossama Mohamed Elhusseiny Abdelsalam

Theses and Dissertations

Increasing environmental concerns regarding climate change and the intensifying challenge of water scarcity in Egypt necessitate the development of innovative, sustainable, and resource-efficient strategies for wastewater reuse. In the built environment, greywater constitutes a significant, relatively low-contaminant wastewater stream that, if treated to comply with Egyptian Codes and relevant international standards, can be safely reused for non-potable applications such as irrigation, landscaping, and building services. This research investigates the efficacy of an integrated green wall panel system, installed on building façades, for decentralized greywater treatment under Egypt’s climatic and environmental conditions, while simultaneously enhancing hygrothermal performance to reduce building energy …


Family Caregivers And Suicide Prevention: A Needs And Assets Assessment In Egypt, Lina Osama Allam Jan 2026

Family Caregivers And Suicide Prevention: A Needs And Assets Assessment In Egypt, Lina Osama Allam

Theses and Dissertations

In the Arab world, suicide prevention is shaped by cultural stigma and religious beliefs, shaping both help-seeking behaviors and the design of support systems. Family caregivers play a vital role in suicide prevention but often face significant emotional and logistical burdens. This study is the first known scholarly effort in Egypt to examine the intervention needs of these caregivers. It explored three key questions: the roles and challenges of caregivers supporting individuals with suicidal thoughts or behaviors; the availability of clinical and community-based resources; and the characteristics of future interventions to support them. A total of 92 mental health professionals …


Targeting The Cd47/Calreticulin Axis In Triple Negative Breast Cancer Using Ha Grafted Chitosan Nanoparticles Loaded With Doxorubicin And Polygodial, Hadir M. Emara Jan 2026

Targeting The Cd47/Calreticulin Axis In Triple Negative Breast Cancer Using Ha Grafted Chitosan Nanoparticles Loaded With Doxorubicin And Polygodial, Hadir M. Emara

Theses and Dissertations

Background: Triple-negative breast cancer (TNBC) is considered the most aggressive subtype of breast cancer. Although progress in cancer treatment has led to better results for different types of breast cancer, TNBC remains particularly challenging due to persistent resistance to both chemotherapy and immunotherapy. This resistance ultimately renders chemotherapy less effective and is frequently associated with substantial side effects. Immunosurveillance significantly impacts the onset of cancer, the rise of resistance to therapies, and the likelihood of tumor recurrence. In this immunomodulatory process, Cluster of Differentiation 47 (CD47) and Calreticulin (CALR) are two key regulators. CD47 expression is strongly linked to anti-phagocytic …


An Impact Assessment Of The Effectiveness Of Utilizing Informal Health Communication Interventions To Spread Health Recommendations And Change Public Perception, Lina Mohamed Ezzat Ahmed Abdel Mawgoud Jan 2026

An Impact Assessment Of The Effectiveness Of Utilizing Informal Health Communication Interventions To Spread Health Recommendations And Change Public Perception, Lina Mohamed Ezzat Ahmed Abdel Mawgoud

Theses and Dissertations

Brain health is an increasingly urgent but critically under-addressed public health priority in Egypt and the wider MENA region. Despite its centrality to aging, productivity, and overall quality of life, public understanding of brain health remains limited, and stigma continues to shape responses to dementia and cognitive decline. This study evaluates the effectiveness of informal, culturally adapted health communication as a tool to shift perception, increase awareness, and promote behavior change among non-medically trained adults in Egypt.

Grounded in global evidence on cognitive reserve, neuroplasticity, and the life-course approach to brain health, the intervention translated expert-informed brain health recommendations into …


A Virtual-Reality-Based Dental Simulator For Endodontics With Automated Formative Feedback, Yousef Salah Abo El Ela Jan 2026

A Virtual-Reality-Based Dental Simulator For Endodontics With Automated Formative Feedback, Yousef Salah Abo El Ela

Theses and Dissertations

Advancements in virtual reality (VR) and haptic technology are transforming the landscape of medical and dental education, offering new avenues for safe, immersive, and repeatable training experiences. Within dentistry, endodontics presents unique challenges for preclinical education due to anatomical complexity, limited access to extracted teeth, ethical concerns, and the shortcomings of conventional plastic models. Despite endodontics specific plastic teeth being available, they fall short of replicating the hardness of real extracted teeth, are relatively costly compared to generic plastic teeth, and are ultimately a disposable item which makes them inadequate as a sustainable long-term solution. Extracted teeth do a much …


Copper Metal Organic Framework-Based Nanomaterial For Non-Enzymatic Glucose Electrochemical Sensor, Sameha Mohamed Sadek Jan 2026

Copper Metal Organic Framework-Based Nanomaterial For Non-Enzymatic Glucose Electrochemical Sensor, Sameha Mohamed Sadek

Theses and Dissertations

This thesis examines the development of non-enzymatic glucose sensors by engineering advanced electrode materials based on metal-organic frameworks (MOFs). Conventional enzymatic glucose sensors, although widely used, suffer from inherent limitations, including poor long-term stability, narrow operating conditions, and sensitivity to environmental factors, due to their reliance on biological enzymes. Non-enzymatic sensors offer a more robust alternative by enabling direct electrochemical oxidation of glucose on engineered electrode surfaces. MOFs represent a highly tunable class of hybrid materials with structural and chemical features that are ideal for sensor applications, including a high surface area, tailored porosity, and excellent thermal and chemical stability. …


Investigating The Risk Factors Affecting The Control Of Diabetes And Hypertension In The Refugees Living In Egypt, Noura Seada Jan 2026

Investigating The Risk Factors Affecting The Control Of Diabetes And Hypertension In The Refugees Living In Egypt, Noura Seada

Theses and Dissertations

Introduction: Non-Communicable Diseases (NCDs) account for 74% of global deaths, with high prevalence of Diabetes and Hypertension worldwide. Egypt hosts over 1 million registered refugees and asylum seekers, often lacking inclusion in social protection or insurance schemes. This study aimed to assess the factors affecting the control of Type 2 Diabetes (T2D) and Hypertension (HTN) among Syrian and Sudanese refugees in Egypt, focusing on healthcare access, sociodemographic characteristics, lifestyle, and health behaviours.

Methods: This study employed a cross-sectional design using a self-administered questionnaire and BMI measurement. Data were collected from 246 refugees diagnosed with type T2D and/or HTN in the …


Preoperative Malnutrition Is Associated With Increased Postoperative Complications Following Lumbar Fusion: A Propensity-Matched Analysis, Ali Mehaidli, Muaaz Wajahath, Jad Lawand, Omar Abdalla, Lorenzo Deveza, Noah Hodson, Ryan J Berger, Kevin Taliaferro Jan 2026

Preoperative Malnutrition Is Associated With Increased Postoperative Complications Following Lumbar Fusion: A Propensity-Matched Analysis, Ali Mehaidli, Muaaz Wajahath, Jad Lawand, Omar Abdalla, Lorenzo Deveza, Noah Hodson, Ryan J Berger, Kevin Taliaferro

Faculty, Staff and Students Publications

Background: Lumbar fusion (LF) is a common surgical intervention for degenerative spinal conditions but carries significant short- and long-term risks. Preoperative malnutrition, characterized by low serum albumin or leukocyte counts, impairs wound healing and increases susceptibility to infection, yet its influence on LF outcomes remains underexplored. This study evaluates the association between preoperative malnutrition and long-term postoperative outcomes following LF.

Methods: Adult patients undergoing LF between 2003 and 2023 were identified in the TriNetX US Collaborative Network. Malnutrition was defined as serum albumin < 3.5 g/dL or leukocyte count < 1,500/mm3 within 1 year preoperatively. A 1:1 propensity score match was performed for demographics, comorbidities, surgical approach, and body mass index (BMI), yielding two cohorts (n=20,693 each). Ninety-day and 5‑year postoperative outcomes were compared using hazard ratios (HRs) with 95% confidence intervals (CIs).

Results: Malnourished patients experienced significantly higher 90‑day rates of transfusion (8.4% vs. 4.5%; HR 1.87, 95% CI: …


Making Waves In Tampa Bay: Experiential Learning On The R/V F.G Walton Smith, Madelyn Krischer, Hannah Harrison, Emma Graves, Sarah Campbell, Ana Arellano Jan 2026

Making Waves In Tampa Bay: Experiential Learning On The R/V F.G Walton Smith, Madelyn Krischer, Hannah Harrison, Emma Graves, Sarah Campbell, Ana Arellano

Making Waves REU

The field of marine science is vast and constantly growing. There are a number of ways an individualmay benefit from experiential learning, whether in education or in their career.


Cancer Vaccine Targeting Mutated Gnaq-Expressing Uveal Melanoma, Vitali Alexeev, Mizue Terai, Sergei Koshkin, Olga Igoucheva, Takami Sato Jan 2026

Cancer Vaccine Targeting Mutated Gnaq-Expressing Uveal Melanoma, Vitali Alexeev, Mizue Terai, Sergei Koshkin, Olga Igoucheva, Takami Sato

Department of Medical Oncology Faculty Papers

Background/Objectives: Uveal melanoma (UM) is the most common intraocular malignancy in adults. Although brachytherapy of the primary tumor provides an approximate 80% five-year survival, with time, nearly half of patients experience predominant liver metastases. It was proposed that malignant cells migrate early and stay dormant as they adapt to the liver microenvironment. We propose that cancer vaccine-mediated activation of UM-targeted immunity in primary UM patients could prevent progression of metastatic disease from dormant cells or malignant seeds. Thus, this study explored DNA vaccination as a measure to educate the immune system to recognize the most common UM-associated Q209L tumor driver …


Teachers’ Perception And Challenges Of Online Education In Uae: A Quantitative Study, Ghadah Al Murshidi, Laila Mohebi, K. Kavitha, Roohi Kursheed Khan, Ahmed Al Zaabi Jan 2026

Teachers’ Perception And Challenges Of Online Education In Uae: A Quantitative Study, Ghadah Al Murshidi, Laila Mohebi, K. Kavitha, Roohi Kursheed Khan, Ahmed Al Zaabi

All Works

This study analyzes survey data from teachers in UAE educational institutions to examine their perceptions towards the benefits and challenges of online learning, with a focus on student engagement, technical barriers, and instructional effectiveness. In light of changing educational paradigms, the study examines teachers’ perceptions of online learning success and the challenges it presents, including technical issues, concerns about student involvement, and academic integrity. A survey was conducted among teachers in the UAE to gather data on online education, ensuring representation across genders, age groups, educational backgrounds, and geographic areas. The study highlights the benefits of online learn-ing, including its …


Global Dose Prescription Variances Exemplified Through Oropharynx Cancer: When Is 70 Gray 70 Gray?, Christian Rønn Hansen, Tony Tadic, Manju Sharma, Gareth Price, Jens Petersen, Mohamed A Naser, Ying Xiao, Nataliya Kovalchuk, Pernille Lassen, Jens Overgaard, Lachlan Mcdowell, Prabhakar Ramachandran, Jun Won Kim, Clifton David Fuller, David J Thomson, Jørgen Johansen, Jeppe Friborg, Sue S Yom, Andrew Hope Jan 2026

Global Dose Prescription Variances Exemplified Through Oropharynx Cancer: When Is 70 Gray 70 Gray?, Christian Rønn Hansen, Tony Tadic, Manju Sharma, Gareth Price, Jens Petersen, Mohamed A Naser, Ying Xiao, Nataliya Kovalchuk, Pernille Lassen, Jens Overgaard, Lachlan Mcdowell, Prabhakar Ramachandran, Jun Won Kim, Clifton David Fuller, David J Thomson, Jørgen Johansen, Jeppe Friborg, Sue S Yom, Andrew Hope

Faculty, Staff and Student Publications

Purpose/objectives: Radiation therapy treatment planning hinges on a critical factor: the prescribed dose. Surprisingly, there is no consistent, standardized global approach to evaluating the dosimetry of this prescription across different centers treating head and neck cancer (HNC). This study aimed to quantify global dose variations for identical prescriptions across international centers treating oropharyngeal cancer, to establish the foundation for future outcome-based studies and improve consistency of interpretation worldwide.

Materials and methods: The study included patients with oropharyngeal cancer who were consecutively treated from 2017 onward with intensity-modulated radiation therapy or volumetric modulated arc therapy at 8 globally recognized radiation therapy …


Thresholds Of Wave Forcing: Implications For Atoll Reef Dynamics Under Sea Level Rise, Mathilde Lindhart, Gerd Masselink, Ashley Holsclaw, Tim Scott Jan 2026

Thresholds Of Wave Forcing: Implications For Atoll Reef Dynamics Under Sea Level Rise, Mathilde Lindhart, Gerd Masselink, Ashley Holsclaw, Tim Scott

School of Biological and Marine Sciences

We investigate the response of shallow reef flow to tidal variability and wave exposure during a 4-month field campaign in southern Huvadhu Atoll, Maldives. Incident waves breaking on steep fore reefs and reef crests generate a setup proportional to offshore wave height that drives a cross-reef flow. We emphasize a critical threshold—where the depth on the reef flat equals the depth at wave breaking—that separates two distinct reef flow regimes: one dominated by strong, unidirectional flow from the ocean into the lagoon and another where wave breaking ceases, flow rates decrease, and occasionally reverse direction. Recognizing the relative importance of …


Factors Associated With Upstaging In Patients With Resectable Non-Small Cell Lung Cancer: A Modern Institutional Sample, Sneha Alaparthi, Hamza Rshaidat, Luke Meredith, Scott H. Koeneman, Christina Grindley, Jacob Heilizer, Purab Kothari, Prarthna Chandar, Tyler Grenda, Nathaniel R. Evans Iii, Olugbenga T. Okusanya Jan 2026

Factors Associated With Upstaging In Patients With Resectable Non-Small Cell Lung Cancer: A Modern Institutional Sample, Sneha Alaparthi, Hamza Rshaidat, Luke Meredith, Scott H. Koeneman, Christina Grindley, Jacob Heilizer, Purab Kothari, Prarthna Chandar, Tyler Grenda, Nathaniel R. Evans Iii, Olugbenga T. Okusanya

Department of Surgery Faculty Papers

BACKGROUND: There is significant value in predicting and better assessing patients who are at risk of post-surgery upstaging in lung cancer. The objective of this study is to review patients who were upstaged following resection and evaluate their clinical and demographic data to elucidate which factors portend an increased risk of pathologic upstaging at our institution (the Thomas Jefferson University Hospital).

METHODS: A retrospective review of institutional data was performed between 2011 and 2023. Patients with stage I-II non-small cell lung cancer (NSCLC) were included. Patients were excluded if they received neoadjuvant systemic therapy, including chemotherapy and/or immunotherapy, and were …


Mechanical Characterization And Modeling Of Rat Myocardia Under The Influence Of Epirubicin, Abdallah Mahmoud Alkhaiyat Jan 2026

Mechanical Characterization And Modeling Of Rat Myocardia Under The Influence Of Epirubicin, Abdallah Mahmoud Alkhaiyat

Theses and Dissertations

Cancer remains a predominant health challenge that is responsible for a significant portion of global morbidity and mortality. Epirubicin (EPI), a chemotherapeutic anti-cancer drug, has shown remarkable efficacy in combating various malignancies. However, it is known to have undesirable side effects on the heart, collectively referred to as cardiotoxicity. This research investigates the adverse effects of chemotherapy on cardiac contractility through an in vitro examination of the mechanics of healthy and infarcted animal heart tissues. Electrically stimulated slices of rat ventricular tissue were tested using an isometric force measurement tissue bath. The tissue slices were subjected to uniaxial stretching, allowing …