Digital Commons Network^™

A Dynamical Systems Analysis Of Amyloid-Beta Production, Caroline Lloyd

Theses and Dissertations

Alzheimer’s disease is characterized by the presence of beta-amyloid (A𝛽) plaques in the brain, caused by an accumulation of misfolded A𝛽 proteins. Research suggests that hallmark proteins involved in neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and Amyotrophic Lateral Sclerosis (ALS) exhibit prion- like behavior. This means that the misfolded, pathogenic proteins influence non- pathogenic proteins to misfold. There is also a small rate of spontaneous conversion which causes A𝛽 to misfold without the presence of pathogenic proteins. Additionally, events that limit blood flow to the brain, such as strokes or direct trauma, are known to increase A𝛽 in …

Factorized Electron-Nuclear Dynamics: Theory Development And Implementation, Julian Stetzler

Theses and Dissertations

In the Born-Oppenheimer (BO) approximation, nuclei are treated as classical particles. The theoretical and computational approaches that go beyond it are impractical for all but the smallest chemical systems. However, such methods are necessary to simulate many photochemical and biological processes. This thesis discusses two important topics of research in this feld: frst, improving electronic structure theory to efciently describe quantum nuclei; second, developing a scalable quantum dynamics method, the factorized electron-nuclear dynamics (FENDy).

Following the BO approximation, the electronic structure of molecules is routinely examined for static arrangements of point nuclei, which is a highly useful premise but not …

Coastal Development Effects On Estuarine Benthic Microalgal Communities, Henry Christopher Guy

Theses and Dissertations

As key drivers of neritic primary productivity, benthic microalgae (BMA) play essential roles in biogeochemical cycling and estuarine food webs. When considered alongside their shallow, restricted habitats, BMA contribute disproportionately to global carbon fixation. However, the extent of human impact on BMA communities is largely unknown. This study aimed to quantify anthropogenic forcing through specific abiotic drivers of benthic microalgal success. BMA biomass, community composition, porewater nutrients, and sediment composition were measured within two South Carolina Estuaries. North Inlet and Murrells Inlet share similar geographic and morphological characteristics but differ significantly in terms of watershed population. Dissolved phosphate, nitrate, and …

“Properly Dependent”: Critical Feminist Narratives Of Wives Of International Students In The United States, Katherine Jane Hopkins

Theses and Dissertations

The F-2 dependent visa in the United States is for spouses and children who accompany a F-1 international student during their studies. One of the defining characteristics of the F-2 visa is that the holder is prohibited from holding any kind of employment. Limited demographic data indicate that the majority of F-2 visa holders are women accompanying their husbands. Many of these women hold advanced degrees and were employed in their home countries prior to relocating to support their husband’s academic pursuits. As a result of the visa restrictions, international student wives typically stay at home while their husbands work …

An Examination Of Gendered Experiences In Undergraduate Engineering Education With Emphasis On Participation, Validation, And Persistence, Madison Lynn Burlett

Theses and Dissertations

This study investigates gendered experiences in undergraduate engineering education, with particular attention to academic validation, participation, and belonging. While prior research suggests disparities in retention and representation, these patterns are often examined through quantitative metrics such as grades, self-efficacy, or survey- based perceptions. Such approaches can provide limited insight into how students interpret and navigate engineering environments in practice. This study adds to the existing body of research by examining students’ lived academic experiences through qualitative analysis.

Semi-structured interviews were conducted with undergraduate engineering students across multiple disciplines and academic levels. Interviews elicited detailed accounts of how students approached academic …

Soil Macroinvertebrate Biodiversity Patterns In Congaree National Park And The Role Of Dna Barcoding, Sharon Ann Kendrick

Theses and Dissertations

Soil and leaf-litter invertebrates are important components of terrestrial biodiversity and contribute to key ecosystem processes such as decomposition, nutrient cycling, and soil formation. Despite their ecological importance, these communities remain difficult to document because many taxa are small, cryptic, or challenging to identify using morphology alone. This study examined patterns of soil macroinvertebrate biodiversity across habitats within Congaree National Park while also evaluating the usefulness of DNA barcoding for documenting taxonomic diversity. Sampling was conducted at 39 sites between September 2022 and October 2024 across upland, bottomland, and bluff habitats. Macroinvertebrates were collected separately from leaf litter and soil …

Deep Learning Algorithms For Generative Materials Design And Composition Based Property Prediction, Rongzhi Dong

Theses and Dissertations

The accelerated discovery of novel functional materials is critical for advancing trans- formative technologies in energy storage, electronics, and catalysis. Current discovery strategies, whether experimental trial-and-error or DFT-based computational screen- ing, are fundamentally constrained by the limited size and diversity of existing materials databases and the difculty of building predictive models that generalize beyond known compounds. Despite signifcant progress in both experimental and computational approaches, two central challenges persist in modern materials science: generating large numbers of realistic, stable, and synthesizable materials outside existing databases, and developing machine learning models capable of accurately inferring structures and predicting properties under realistic …

Sex Differences In Cardiac Autonomic Response To Physical Exertion Following Concussion In Adolescents, Kiersten Isabella Mangold

Theses and Dissertations

Concussions, or mild traumatic brain injuries, are common amongst adolescent populations. Despite the qualifier of “mild”, these injuries can have a lasting impact on quality of life and school function. It has long been suggested that females experience poorer outcomes following concussion compared to their male counterparts, yet much research focuses primarily on male populations. Various theories have been proposed to explain these reported sex differences in concussion outcomes, ranging from socio-cultural differences in symptom reporting to neuroanatomical differences and the influence of sex hormones. Cardiac autonomic function (C-ANS) has emerged as a potential contributing mechanism to post-concussive symptoms. Although …

A Comparative Analysis Of State Legislation Prohibiting Gender-Affirming Care For Missouri Minors: A Policy Review, Hayley Lange, Benjamin Grin, Kaitlyn Crosby

Missouri Policy Journal

The Save Adolescents from Experimentation (SAFE) Act is a law enacted in August 2023 that banned gender-affirming medical care for individuals under 18 in Missouri. It states that any medical provider who provides medical gender-affirming care to a minor will have their professional medical license revoked. The purpose of this policy review is to evaluate and compare the content of the Missouri SAFE Act with similar legislation enacted in other states to provide an evaluative model.        

This policy assessment used a modified assessment tool that was developed by the Centers for Disease Control and Prevention (CDC). The assessment included a …

Daily Eastern News: April 01, 2026, Eastern Illinois University

Daily Eastern News: 2025-2026

No abstract provided.

Habitat Preference Of Invasive Lionfish (Pterois Spp.) In The Gulf Of Mexico, River Barnett

Theses & ETDs

Lionfish (Pterois spp.) are an invasive species in the Gulf of Mexico that originated from the Indo-Pacific. They have no natural predators within this area and are known to prey on anything they can fit into their mouths, as well as having a high fecundity rate. This thesis investigated the habitat preferences of the invasive lionfish (Pterois volitans and P. miles) in the Gulf of Mexico, focusing on depth distribution and substrate preference. Specifically looking at quantifying depth-related patterns in lionfish abundance across shallow (< 20 m), intermediate (20–40 m), and mesophotic (>40 m) zones, assessing the influence of habitat structure, including artificial and natural habitats, on …

Introduction To The Plant-Parasitic Nematodes Affecting Row Crops In South Carolina, Jonathan K. Croft, G. Kyle Smith, Jay Crouch, William J. Hardy Iii, Shelby Hammond, John D. Mueller

Introductory Materials

Knowledge of the biology, host range, overwintering habits, damage thresholds, and life cycles of problem nematode species is necessary to optimize the design of effective management schemes. The following is a summary of the relevant facts for the important plant-parasitic nematode species affecting South Carolina row crops.

Efficacy Analysis In Clinical Trials: A Comprehensive Review Of Statistical And Machine Learning Approaches, Dhrubajyoti Ghosh, Samhita Pal

Faculty Articles

Efficacy testing is a cornerstone of clinical trials, ensuring that medical interventions achieve their intended therapeutic effects. Over the decades, a wide range of statistical methodologies have been developed to address the complexities of clinical trial data, including parametric, nonparametric, Bayesian, and machine learning approaches. Parametric methods, such as t-tests, ANOVA, and LMMs, have traditionally been the foundation of efficacy testing due to their efficiency under well-defined assumptions. Nonparametric techniques, including the Friedman test, Brunner-Munzel test, and modern extensions like nparLD, have emerged as robust alternatives, particularly for skewed, ordinal, or non-normal data. Bayesian methodologies have enabled the incorporation of …

Testing The Intermediate Disturbance Hypothesis On Anthropogenic Pressure In Central Alabama, Gavin Terrell

Theses

Biodiversity is fundamental to maintaining ecosystem structure and function globally. Prior to the late 20th century, ecological theory generally predicted that biodiversity would be highest in systems experiencing minimal disturbance. However, Joseph H. Connell challenged this view with the Intermediate Disturbance Hypothesis (IDH), which posits that species diversity peaks at intermediate levels of disturbance and declines under conditions of both low and high disturbance. Although widely cited, the applicability of the IDH to natural systems remains debated, particularly in the context of anthropogenic disturbances and when diversity is measured beyond species richness alone.

This study evaluated the predictions of the …

Assessing The Influence Of Temperature And Water Level On Gill Disease In Goldfish, Moses Elijah Cadawas, Emmalie Turner, Darlene Panvini

SPARK Symposium Presentations

Gill disease in fish is a strong biological indicator of water quality and environmental stress. These diseases are commonly caused by bacterial or parasitic infections that target gill tissues and can lead to severe physiological impairment and ultimately mortality. Several environmental factors, including water level and temperature, play a critical role in determining fish susceptibility to these infections. Changes in these conditions can act as stressors that weaken immune defenses and promote pathogen proliferation. This study aimed to evaluate the relative impact of environmental stressors on the development of gill-associated disease in Carassius auratus (goldfish) under controlled conditions. Following exposure …

Evaluating The Efficacy Of Glp-1 Receptor Agonists On Glycemic Control And Cardiovascular Outcomes, Canna Malaikham

SPARK Symposium Presentations

The mechanisms of action, pharmacokinetics, clinical efficacy, and safety of glucagon-like peptide-1 (GLP-1) receptor agonists have been evaluated for the treatment of both type 2 diabetes and obesity. The purpose of the literature review was to assess the clinical benefit and potential risk of GLP-1 receptor agonists by examining the mechanism(s) of action of drugs that utilize a variety of signaling pathways by activating receptors on specific cells. The literature reviews include: (a) Mechanistic studies of molecular signaling; (b) Pharmacokinetic analysis of the plasma concentration of drugs post-dosing; (c) Randomized controlled trials of drugs to evaluate their effectiveness; and (d) …

A Rubric-Based Evaluation Of Mote Marine Aquarium’S Curriculum, Alexis Williams

Theses & ETDs

Informal science institutions such as aquariums play a critical role in shaping students’ engagement with and understanding of scientific concepts, particularly outside traditional classroom settings. This study addresses a gap in existing research by examining curriculum design rather than solely student outcomes, focusing on middle school programs at Mote Marine Aquarium. A theory-aligned rubric grounded in the Four-Phased Model of Interest Development, intrinsic motivation, three-dimensional learning, and the Contextual Model of Learning was developed and applied to evaluate three lessons: Marine Ecology, Ocean Technology, and Marine Biomedical. The analysis assessed inquiry-based learning, real-world connections, reflection, collaboration, and support for interest …

Assessing The Role Of Fisheries In The Decline Of Seabird Populations Off The Coast Of Chile, Karen Robertson

Theses & ETDs

Seabirds have been in decline globally with an overall decrease of nearly 70% between 1950 and 2010 highlighting pressure on these systems. Seabirds are important due to the ecosystem functions and services they provide, nutrient transfer, population regulation, ecotourism attraction and overall indicators of ecosystem health. The coast of Chile is a leading area in productivity, resulting in high numbers of seabird species inhabiting its coastal areas. Additionally, it is a leading country in the fishing community, leading to an overlap between fisheries and seabird communities. While there are other threats such as invasive species and climate change contributing to …

Don't Go Near The Water: How Pfas Regulation In North Carolina Is Falling Drastically Short, And How Technology Can Bridge The Gap, Madison Kate Williams

North Carolina Journal of Law & Technology

No abstract provided.

Agronomic Practices For Climate-Resilient Okra Production In Agroecological Systems: A Review, Samuel Mathu Ndungu, Lokeshwar Kesamreddy, Mathieu A.T. Ayenan, Stephen Othim, Siyabusa Mkuhlani, Yu Hsiang Liu, Amha Besufkad, Wubetu Bihon Legesse, Eric C. Legba, Judith Honfoga, Lukas Pawera

All Peer-Reviewed Publications

Okra is increasingly recognized as a climate-resilient crop within diversified agroecological systems; however, an integrated synthesis of its biophysical, agronomic, and socioeconomic dimensions is lacking. This review consolidates the current knowledge on okra physiology, production ecology, and value chains, with a focus on climate resilience under heat, drought, salinity, pest, and disease pressures. Evidence across regions demonstrates that agroecological practices such as crop diversification, mulching, conservation tillage, integrated pest management, and the use of organic and biological inputs consistently improve soil health, stabilize yields under climatic stress, and reduce dependence on external inputs, although with trade-offs in labor demand and …

Postmarketing Safety Of Bimekizumab For Hidradenitis Suppurativa: An Early Pharmacovigilance Analysis Using The United States Food And Drug Administration Adverse Event Reporting System, Simona A. Alomary, Nicole J. Baker, Temitayo Ogunleye, Susan C. Taylor

Student Papers, Posters & Projects

No abstract provided.

Music Listening While Studying And Academic Performance Among College Students With Attention Deficit And Hyperactivity Disorder, Raihan K. Khan, Md Towfiqul Alam, Madalynn Nofplot, Sojib Bin Zaman, Catherine L. Zaman

Faculty Scholarship

Evidence on whether music listening supports academic performance, particularly among students with attention deficit and hyperactivity disorder (ADHD), remains mixed. We explored associations between music listening while studying and academic performance (GPA: grade point average) among college students, and to evaluate whether the associations differed by ADHD status. We analyzed cross-sectional survey data from college students and conducted linear regression models with self-reported GPA as the dependent variable. Models were adjusted for sex, academic level, college affiliation, primary study location, weekly study hours, and preferred genre of music. A total of 541 students participated. Most of the students were at …

Synthesis And In Vitro Evaluation Of Potential Tuberculosis Antibiotics, Chloe Spradlin

Honors Projects

Tuberculosis (TB) remains a major global health threat. The bacteria causing TB, Mycobacterium tuberculosis, has proven difficult to combat, as drug resistance (MDR-TB) continues to develop within the bacteria. Access to healthcare in developing countries complicates the treatment of TB and MDR-TB. The World Health Organization has declared TB a global health crisis and has called for the development of new therapies. Previously, we used AutoDock Vina software to design novel drugs targeting InhA, an enzyme involved in mycobacterial cell wall synthesis. This project focuses on synthesizing amino diphenyl amides (ADA) and screening them against Mycobacterium. The synthetic pathway enables …

Exploring Adolescents’ Social, Cultural, And Health Experiences To Inform Culturally Responsive Interventions, Bria D. Singleton

Theses and Dissertations

This study examined adolescents’ perceptions of their social, cultural, and health-related experiences, assessing constructs related to identity formation, digital exposure, belonging, and safety among Generation Alpha. Using a mixed-methods design, data were collected from students aged 11 to 14 enrolled at a public middle school in South Carolina using a structured survey and qualitative group discussions. Survey findings indicated primarily positive perceptions of school safety and a sense of self-efficacy in caring for their mental health and well-being. However, qualitative findings disclosed the adolescents’ acute awareness of environmental threats, such as gun violence and school shootings, resulting in emotional dysregulation …

Dietary Β-Hydroxybutyrate Sodium Alters Rumen Microbiome And Nutrient Metabolism In The Rumen Epithelium Of Young Goats, Yimin Zhuang, Guanglei Liu, Chuyun Jiang, Mahmoud M. Abdelsattar, Yuze Fu, Ying Li, Naifeng Zhang, Jianmin Chai

Animal Science Faculty Publications and Presentations

The role of β-hydroxybutyric acid (BHBA) includes providing energy, regulating signaling pathways, and ameliorating the gut microbiota in the host, while its nutrient mechanism to improve rumen epithelium development in young ruminants is still unclear. In this study, a total of 12 female Haimen goats with 30 d of age were chosen and divided into two groups. One group was fed with basic diet (CON), and the other group was fed a basal diet supplemented with 6 g d^–1 dietary β-hydroxybutyrate sodium (BHBA-Na). The experimental period was 30 d, and all goats were slaughtered at 60 d of age. …

An Insight Into The Venom Gland Proteome Of The Two-Spined Trap-Jaw Ant, Odontomachus Haematodus, Aaron Morgan

Honors Theses

Ants are ecologically important and highly abundant organisms, playing key roles in many ecosystems. One recently introduced species in the southeastern United States is Odontomachus haematodus (the two-spined trap-jaw ant), a South American native that has often been misidentified, contributing to limited research on its biology and venom composition. This study aimed to provide the first detailed characterization of the venom apparatus and proteome of O. haematodus. Specimens were collected and dissected, and venom-related proteins were extracted and analyzed using SDS-PAGE and tandem mass spectrometry (MS/MS-ESI). Confocal microscopy was also used to visualize the sting apparatus, including F-actin filaments and …

Fisheries Management Paper No.312: Discussion Paper On Management And Licensing Options For The Charter Industry - Statewide Strategic Review Of Western Australia’S Charter Fishing Sector, Department Of Primary Industries And Regional Development, Western Australia

Fisheries Management Papers

This consultation paper has been prepared to support the statewide strategic review of Western Australia’s (WA) charter fishing sector, which was initiated as a government commitment.

The paper details issues and proposals relating to the management and licensing framework, development opportunities and representation model for the charter fishing industry. The proposals have been developed in consultation with the Charter Review Working Group. The Department of Primary Industries and Regional Development (DPIRD) now seeks comment from relevant stakeholders on the issues and proposals outlined within this paper.

Comments provided will assist in providing advice and recommendations to the Minister for Fisheries …

Wright State University's Celebration Of Student Research, Scholarship & Creative Activities From Wednesday, April 1, 2026, Wright State University

Celebration of Undergraduate & Graduate Research, Scholarship, and Creative Activities Materials

The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's Celebration of Student Research, Scholarship & Creative Activities on April 1, 2026.

Simulation And Optimization Of The Active Magnetic Shield Of The N2edm Experiment, N. J. Ayres, G. Ban, G. Bison, K. Bodek, V. Bondar, T. Bouillaud, G. L. Caratsch, E. Chanel, W. Chen, C. Crawford, V. Czamler, C. B. Doorenbos, S. Emmeneger, S. K. Ermakov, M. Ferry, M. Fertl, A. Fratangelo, D. Galbinski, W. C. Griffith, Z. D. Grujic, K. Kirch, V. Kletzl, J. Krempel, B. Lauss, T. Lefort, A. Lejuez, K. Michielsen, J. Micko, P. Mullan, O. Naviliat-Cuncic, F. M. Piegsa

Physics and Astronomy Faculty Publications

The n2EDM experiment at the Paul Scherrer Institute aims to conduct a high-sensitivity search for the electric dipole moment of the neutron. Magnetic stability and control are achieved through a combination of passive shielding, provided by a magnetically shielded room (MSR), and a surrounding active field compensation system by an Active Magnetic Shield (AMS). The AMS is a feedback-controlled system of eight coils spanned on an irregular grid, designed to provide magnetic stability to the enclosed volume by actively suppressing external magnetic disturbances. It can compensate static and variable magnetic fields up to ± 50 μT (homogeneous components) and ± …

Internal Waves, Wind, And Biogeochemistry At The Head Of The Monterey Bay Submarine Canyon, Marisol C. Figueroa

Capstone Projects and Master's Theses

Coastal submarine canyons are dynamic environments where internal waves, wind forcing, and complex bathymetry interact to regulate physical and biogeochemical variability. This study investigates how intra- and interannual variability in internal waves and upwelling-favorable winds influence cold-water mass intrusions and associated biogeochemical responses at the head of the Monterey Bay Submarine Canyon. Using a 2010--2021 time series of nearshore physical and chemical observations from the Moss Landing Marine Laboratories intake system, combined with local and offshore wind measurements, this work examines variability across seasonal to interannual timescales. Results show that semidiurnal M2 internal tides are the primary drivers of cold, …