Digital Commons Network^™

Synthesis, Spectroscopic Characterization, And Photostability Studies Of A New Ligand Derivative Of 4-Bromobenzaldehyde And Its Metal Complexes, Enass J. Waheed, Ali Mudher Abdulkareem, Ibtisam Khalifa Jassim

Baghdad Science Journal

The new Schiff base ligand (L_B) was synthesized by reacting precursor (P) with 4-bromobenzaldehyde. This ligand formed three new complexes: [Pd(L_B)(H₂O)₂]Cl₂ (square planar) and [M(L_B)(H₂O)₂Cl₂].mCl₂ (octahedral), where m=0 for Co⁺² and 1 for Pt⁺⁴, upon reaction with the respective metal ions. Characterization of the ligand (L_B) and its metal complexes involved various techniques including ¹H- and ¹³C-NMR, FT-IR, UV-Vis spectroscopy, magnetic susceptibility measurements, CHNS analysis, and molar conductivity. The photo-stabilization of polymers aims to mitigate …

In Silico Study Of N-Pyrazoline Derivate Compounds As Anticancer Through Inhibition Of Pi3k And Pr Expression, Denny Satria, Syukur Berkat Waruwu, Eti Nurwening Sholikhah, Mustofa Mustofa, Pamungkas Bagus Satriyo, Tutik Dwi Wahyuningsih, Hesti L Wiraswati, Ema Damayanti

Baghdad Science Journal

Breast cancer treatment has many options directed at therapeutic targets, but some remain incurable, so new therapies are needed. Pyrazoline has shown various biological activities, one of which is anticancer effectiveness. The purpose of this study was to conduct an in silico analysis of Pyrazoline inhibition of PI3K and PR proteins using docking and MD simulation methods. Predictions of toxicity and pharmacokinetics, including absorption, distribution, metabolism, excretion, and toxicity, were also conducted computationally. The analysis showed that the Pyrazoline compound had interactions with ligands of PI3K proteins and PR proteins. Pharmacokinetic predictions showed that the compound in the human intestine …

A Correlation Between Leptin Hormone And Other Biochemical Parameters In Iraqi Women With Hepatitis C Virus (Hcv) In Thi-Qar Governorate In Iraq, Hadeel Rashid Faraj, Alyaa Majid, Sarah A Sayer

Baghdad Science Journal

Background: chronic hepatitis C virus (HCV) infection is a major health problem. Females of childbearing age who are infected with hepatitis C are exposed to premature aging of the ovaries, which leads to an imbalance in the levels of sex hormones leptin hormone is associated with all stages of reproductive age. The aim of the present study is to observe levels the liver enzyme, Albumin, total bilirubin, estrogen, progesterone and leptin hormone. Also to evaluate the correlation between ( leptin hormone liver enzyme, Albumin, total bilirubin, estrogen and progesterone ).Methods: Serum liver enzyme, Albumin, total bilirubin, estrogen, progesterone and leptin …

Ft-Mir Spectra Of Fructose And Glutamine-Based Edible Polymer, Ghassan Faisal Mohsin

Baghdad Science Journal

The Maillard mechanism frequently gives numerous varieties of food a distinctive flavor and visually appealing hue. The Maillard reaction (MR) is additionally referred to as the non-enzymatic glycosylation, and MR contain a variety of chemical compounds, including precursors for the brown hue generated in the Maillard reaction and compounds that eventually form melanoidins, which are brown that develop into dark-colored hue nitrogenous polymer molecules. Melanoidin polymer was synthesized by integrating L-glutamine and D-fructose and then scorching the resulting mixture at 130 °C for 20 minutes. Additionally, dialysis was conducted to eliminate low molecular weight fractions. The utilization of Fourier Transform …

Intraspecific Meristic Variation In Gambusia Holbrooki From The Middle East And Its Implications For Stock Structure And Taxonomic Status, Fatema A. Al Fatle, Ana L. Ibaňez, Laith A. Jawad

Baghdad Science Journal

An analysis was conducted on the variation in the counts of seven meristic traits of the eastern mosquito fish, Gambusia holbrooki, using samples collected from ten different sites in the Middle East. These sites are located along the Tigris, Euphrates, and Shatt al-Arab Rivers, spanning across Iraq, Iran,Türkiye, and Syria. The study revealed a northward increase in the average values of these meristic traits, with the highest recorded in Türkiye and the lowest in the southern region of Iraq. The statistical analysis using Boxplots demonstrated that the seven meristic features were distinct across different rivers, with no overlap observed. …

Supplementary Table 2. Colostrum Fatty Acid Content (%) For Cows Supplemented –40 Meq/Kg Dm Dcad Diet +/- 23 G/D Nicotinic Acid Or –80 Meq/Kg Dm Dcad Diet +/- 23 G/D Nicotinic Acid For 28 D Prepartum, Tess Stahl, J. Kraft, Sarah Allen, Peter S. Erickson

Faculty Publications

No abstract provided.

Supplementary Table 3. Colostrum Fatty Acid Yield (G) For Cows Supplemented –40 Meq/Kg Dm Dcad Diet +/- 23 G/D Nicotinic Acid Or –80 Meq/Kg Dm Dcad Diet +/- 23 G/D Nicotinic Acid For 28 D Prepartum, Tess Stahl, J. Kraft, Sarah Allen, Peter S. Erickson

Faculty Publications

No abstract provided.

Dose-Dependent Ifn Programs In Myeloid Cells After Mrna And Adenovirus Covid-19 Vaccination., Giray N Eryilmaz, Yilmaz Yucehan Yazici, Radu Marches, Eleni P Mimitou, Lisa Kenyon-Pesce, Kim Handrejk, Sonia Jangra, Michael Schotsaert, Adolfo García-Sastre, George A Kuchel, Jacques Banchereau, Duygu Ucar

Faculty Research 2026

BACKGROUNDThe SARS-CoV-2 pandemic provided a rare opportunity to study how human immune responses develop to a novel viral antigen delivered through different vaccine platforms. However, to date, no study has directly compared immune responses to all 3 FDA-approved COVID-19 vaccines at single-cell multiomic resolution.METHODSWe longitudinally profiled SARS-CoV-2-naive adults (n = 31) vaccinated with BNT162b2, mRNA-1273, or Ad26.COV2.S, integrating plasma cytokines, antibody titers, and single-cell multiomic data (DOGMA-Seq).RESULTSWe discovered a distinct, transient IFN program termed ISG-dim, which emerged specifically 1-2 days after the first mRNA dose in approximately 10% of myeloid cells. This state was characterized by ISGF3 complex activation and …

Role Of Piezo1 Channels Expressed In Pvn In Regulating Sympathetic Nerve Activity And Arterial Blood Pressure In Rats, Yue Chen, Wei Guo, Jichun Wang, Min Wang, Yuying Yang, Gregory Miodonski, Enshe Jiang, Qing Hui Chen, Yi Yang, Renjun Wang

Michigan Tech Publications

Mechanosensitive Piezo1 channels participate in regulating pain sensitivity, insulin secretion, and vascular tension; however, their expression in the autonomic paraventricular nucleus (PVN) and role in modulating sympathetic outflow and cardiovascular function remain unstudied. In this study, unilateral PVN microinjection of the Piezo1 channel blocker Dooku1 (0.1, 1, 10, 100, and 200 pmol) administered to anesthetized male rats increased renal sympathetic nerve activity (RSNA) and mean artery pressure (MAP) in a dose-dependent manner, with maximum increases of 93 ± 30% (p < 0.0001) and 21 ± 5 mmHg (p < 0.0001), respectively, elicited by Dooku1 at 100 pmol. Similarly, PVN microinjection of the peptide Piezo1 channel blocker GsMTx4 (1 nmol) significantly increased RSNA (p < 0.001) and MAP (p < 0.0001). Conversely, PVN-microinjected Piezo1 channel activators Yoda1 (5 nmol) and Jedi2 (5 nmol) did not significantly alter RSNA or MAP. Western blot and qRT-PCR analyses of the hypothalamic PVN showed abundant Piezo1 mRNA and protein expression. Immunofluorescence detection showed that Piezo1 was expressed in pre-sympathetic PVN neurons with axons projecting to the rostral ventrolateral medulla. We conclude that Piezo1 channels expressed in the autonomic PVN neurons play an important role in regulating sympathetic outflow and cardiovascular function.

Quenching-Based Electrochemiluminescence Detection Of Chlorpyrifos Using A Portable Sensor Platform, Emre Dokuzparmak

Turkish Journal of Biology

Background/aim: Chlorpyrifos (CPF) is an organophosphate pesticide extensively used in agriculture, posing significant threats to human health due to its neurotoxic effects. Its presence in food products has raised considerable public health concerns, necessitating the development of rapid, sensitive, and reliable detection methods. This study aims to design and validate an electrochemiluminescence (ECL) sensor platform operating via a quenching-based mechanism to enable ultrasensitive detection of CPF in food matrices.

Materials and methods: The sensing strategy exploits the coreactant mechanism between 2-(dibutylamino)ethanol (DBAE) and [Ru(bpy)₃]²+ (tris(2,2′-bipyridyl)ruthenium(II)), wherein CPF suppresses the ECL emission by interfering with the excited-state electron transfer pathway. The …

Investigation Of Antimicrobial Synergism Of Actinomycin Derivatives From Streptomyces Parvus 35m1 Against Escherichia Coli Atcc 25922, Özge Can, Mustafa Ünver Kurt, Meli̇s Küçüksolak, Ataç Uzel, Erdal Bedi̇r

Turkish Journal of Biology

Background/aim: Limited drug development and increased antibiotic tolerance among Gram-negative bacteria have led researchers to consider combination therapy. Actinomycin derivatives, particularly actinomycin D, exhibit a wide range of bioactivities, including antibacterial effects. However, actinomycin D is less effective against Gram-negative pathogens. Therefore, it is essential to demonstrate the synergy of actinomycin D and its derivatives with clinically known antibiotics against Escherichia coli ATCC 25922 and investigate the effects on cellular morphology.

Materials and methods: Streptomyces parvus 35M1 isolated from coastal sediment in İzmir/Türkiye was identified via genome sequencing. Large-scale (30 L) fermentation followed by chromatographic purification yielded compounds 1 (actinomycin …

Transcriptomic Identification And Developmental Mapping Of Nrg3b Expression In Zebrafish, Elham Tarahomi, Nuray Soğünmez Erdoğan

Turkish Journal of Biology

Background/aim: Neuregulin 3 (NRG3) is an epidermal growth factor-like ligand that is involved in neuronal circuit formation in mammals. However, the expression profile of its zebrafish ortholog, nrg3b, remains poorly defined. The transcriptomic analyses of zebrafish sco-spondin mutants, which display alterations in their neurodevelopmental pathways, have indicated potential dysregulation of Nrg3b. Guided by these insights, this study aimed to characterize the temporal and spatial expression patterns of nrg3b in vivo in embryonic and adult zebrafish.

Materials and methods: Publicly available RNA-seq data from heterozygous and maternal-zygotic zebrafish sco-spondin mutants at 5, 15, and 30 days postfertilization (dpf) were analyzed to …

Cover And Contents

Turkish Journal of Biology

No abstract provided.

Biological Evaluation Of Novel 6,9-Disubstituted Purine Analogues In High-Grade Serous Ovarian Cancer Cell Lines, Duygu Altiparmak, Deren Demi̇rel Yavuz, Pinar Kul Karadeni̇zli̇, İrem Durmaz Şahi̇n, Meral Tunçbi̇lek

Turkish Journal of Biology

Background/aim: High-grade serous ovarian cancer (HGSOC) remains one of the most aggressive forms of ovarian malignancy and frequently shows resistance to conventional therapies. This study aimed to synthesize a novel series of purine analogues, 6-[(4-substituted benzyl amine)/(4-substituted aniline)]-9-cyclopentyl purines, and evaluate their anticancer efficacy against HGSOC cell lines.

Materials and methods: We assessed the biological effects of the synthesized purine analogues on the OVCAR3, OVSAHO, and KURAMOCHI HGSOC cell lines using the sulforhodamine B assay. To investigate the mechanism of action, we conducted flow cytometry and western blot analyses, focusing on DNA replication and apoptosis.

Results: Among the tested compounds, …

Crow's Nest, February 23, 2026, Crow's Nest Staff

Crow's Nest

The February 23, 2026 issue of Crow's Nest.

The Rider (2026-02-23), Daniela Chapa-Reyes

The Rider Archives

Vol. 11, No. 20

Mcsa Forum Minutes 02/23/2026, Morris Campus Student Association

Morris Campus Student Association

No abstract provided.

The Echo: February 23, 2026, Taylor University

2025-2026 (Volume 113)

No abstract provided.

Synthesis, Characterization, And Anticancer Activity Study Of New Curcumin Analogues Against Mda-Mb 231 Breast Cancer Cell Line, Ola A. Odah, Rita S Elias, Shaker A. N. Al-Jadaan

Baghdad Science Journal

Synthesis of six new curcumin analogues was performed through condensation reaction of 3-methyl-2, 4-pentandione with substituted aromatic aldehyde derivatives and boron oxide in the presence of trimethylborate and butylamine. The reaction was carried out under ultrasonic irradiation. The synthesized compounds were identified using ¹H-, ¹³C-NMR, FT-IR spectroscopy, and electron impact mass spectrometry. The Swiss ADME website was used to predict the physicochemical properties of the new compounds using computational techniques like ADME studies. All produced compounds, according to this study, complies with the Lipinski rule of five. The microculture tetrazolium (MTT) assay was utilized to assess the investigated …

The Impact Of Vascular Endothelial Growth Factor, Neutrophil Gelatinase-Associated Lipocalin, And Interleukin-38 Food And Air Allergy Patients Following The Pandemic Of Covid-19 In Iraq, Esraa Hameed Khamees, Zaizafoon N. Nasif

Baghdad Science Journal

Allergies are a common health issue where the immune system reacts to substances in the environment that are normally harmless. This study further investigates the effects of vascular endothelial growth factor (VEGF), neutrophil gelatinase-associated lipocalin (NGAL), interleukin-38 (IL-38), immunoglobulin E (IgE), and the neutrophil-lymphocyte ratio (NLR) in these individuals, offering insight into the probable processes behind allergic responses following the pandemic. The study comprised 120 non-vaccinated females with previous COVID-19 infection. Groups included controls and food and air (F&A) allergic patients, with 60 individuals matched for age and gender. Serum levels of IL-38, VEGF, IgE, and NGLA were assessed using …

Breast Cancer Mortality In Memphis: A Holistic Approach - Research Findings And Strategies For Improved Outcomes In Segregated Communities, The Benjamin L. Hooks Institute For Social Change

The Hooks Institute Policy Papers

The Benjamin L. Hooks Institute for Social Change (Hooks Institute) is pleased to present its tenth edition of the policy papers, which focuses on breast health outcomes for women living in racially segregated commu-nities. The research that informed the articles in this publication, as well as this volume of the policy papers itself, was funded by a 2022 grant from the National Institutes of Health (NIH). The grant was awarded to a team of researchers that included Shelley White-Means, PhD (Principal Investigator); Arash Shaban-Nejad, MSc, MPH, PhD and Minghui Li, MSc, PhD (Co-Investigators) at University of Tennessee Health Science Cen-ter …

Unh Research Could Lead To Stronger, Lighter Everyday Materials, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

Preparation, Characterization, And Antimicrobial Evaluation Of A Cefepime Derivative With Divalent Transition Metals, Zahraa A. Jaber, Israa H. Ibraheem, Sahar S. Hassan

Baghdad Science Journal

The Schiff base ligand (L)- 1-((7-((Z), was recently synthesized 2–(2-((Z)–5,5-diethyl2-(methoxyimino)acetamido)-2-(methoxycarbonyl)-2,6-dioxotetrahydropyrimidin-4(1H)-ylideneamino) thiazol-4-yl8-oxo-5-thia , the next mineral ions, Ni²⁺, Cu²⁺, Zn²⁺, and Co²⁺, are permitted to react with 1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl)-1-methylpyrrolidinium, leading to the formation of new metal complexes with distinct geometric shapes. By detecting the shifting in the azomethines band and the appearance of M-N and M-O bands, FT-IR confirmed the occurrence of coordination through N of azobenzene and two O atoms of beta lactam and ester, indicating the development of Schiff base complexes as well as the original Schiff base. Additionally, we can use …

Colleges Face A Choice: Try To Shape Ai’S Impact On Learning, Or Be Redefined By It, Vicki Baker, Linda M. Boland

Biology Faculty Publications

What happens to a college education when a chatbot can draft an essay, summarize a reading and generate computer code in seconds? The arrival of artificial intelligence in college classrooms has been swift and, for many schools, disorienting.

As professors of economics and business management and biology at liberal arts colleges, we are confronting a question that now cuts across all colleges and universities: What is the purpose of a college education, as AI is rapidly reshaping how students think, learn and prepare for careers?

Chimes: February 23, 2026, Calvin University

Chimes

A vibrant tapestry of cultures: Rangeela celebrates 30 years by Ava Roush & Ellerry Johnson

Puentes: Students building bridges amidst immigration concerns by Jorie Cho

Late Night Era's Concert: The end of an era by Ashley Hamons

Cave Night kickoff hosts local artists by Alec DeYoung

Composting streamlined and expanded to all underclassmen dorms by McKenna Wilkinson

Let's talk about sec: Calvin sexuality series confronts purity culture by Sarah Sparling

Scaling rock walls and studying Scripture by Ella Vanden Berg

Supplementary Table 1. Fatty Acid Methyl Esters (% Of Colostrum) For Cows Supplemented –40 Meq/Kg Dm Dcad Diet +/- 23 G/D Nicotinic Acid Or –80 Meq/Kg Dm Dcad Diet +/- 23 G/D Nicotinic Acid For 28 D Prepartum, Tess Stahl, J. Kraft, Sarah Allen, Peter S. Erickson

Faculty Publications

No abstract provided.

Innovative Approaches For Lung Cancer Screening And Interception, Jianjun Zhang, Matthew D Park, Tej Pandya, Elaine Shum, Jia Wu, Simon Heeke, Ramin Salehi-Rad, Thomas U Marron, Zhubo Wei, Hui Li, Torsten G Blum, John V Heymach, Steven M Dubinett, Pan-Chyr Yang, Charles Swanton, Miriam Merad

Faculty, Staff and Student Publications

Lung cancer remains the leading cause of cancer-related deaths worldwide, partly because many patients are diagnosed at late stages, highlighting the urgent need for effective early detection and intervention strategies. Low-dose computed tomography (LDCT)-based screening reduces lung cancer mortality in high-risk populations defined by age and smoking history; however, the uptake of LDCT remains low among eligible individuals. Compounding this issue, modelling studies estimate that nearly half of lung cancers occur in individuals who do not meet eligibility criteria for LDCT-based lung cancer screening under current guidelines. Moreover, LDCT-based screening has inherent limitations, including a high rate of false-positive results …

Supt16h-Associated Neurodevelopmental Disorder And Neurocristopathy: Genetic And Phenotypic Spectrum, Eunhye Lee, Seungmin Sim, Hee-Jung Choi, Eugene Y Liang, Carolyn Le, Roya Bina, Ryan Cohen, Elizabeth George, Soo Yeon Kim, Gifty Bhat, Erin Falsey, Richard Sidlow, Kristin Clinard, Shay Ben-Shachar, Eleina England, Beatriz Menendez, Isabella Herman, Shelly Nielsen, Jaya Punetha, Priya Bhola, J Austin Hamm, Megan A Keeney, Nike Sitzman, Sara Berger, Lakshmi Mehta, Alison J Conn, Lilian Downie, Myla Ashfaq, Hope Northrup, Ange-Line Bruel, Sylvie Odent, Justin O Szot, Noelia Nunez Martinez, Sunju Park, Julie Refkin, Jean-Marc Good, Fabienne Maurer, Cédric Le Caignec, David J Coman, Erin Anderson, Linda J Richards, Ryan J Dean, Caleb Yang, Chulwon Choi, Byung Joon Hwang, Jin Sook Lee, William B Dobyns, Murim Choi, Elliott H Sherr, Jong-Hee Chae, Yun Kee, Emanuela Argilli

Faculty, Staff and Student Publications

SUPT16H encodes a subunit of the FACT (FAcilitates Chromatin Transcription) complex, a histone chaperone essential for maintaining chromatin integrity during transcription, replication, and DNA repair. Pathogenic de novo SUPT16H missense variants have previously been linked to neurodevelopmental disorders in eight individuals. Here, we expand the genotypic and phenotypic spectrum by identifying 24 additional individuals harboring ultrarare heterozygous missense or truncating variants, who share overlapping clinical features including intellectual disability, autism spectrum disorder, hypotonia, and characteristic craniofacial dysmorphism. To elucidate the underlying mechanisms, we generated a supt16h knockout zebrafish model using CRISPR/Cas9. The supt16h loss-of-function (LOF) model recapitulated key patient phenotypes …

Exploring The Role Of Higher Education Leaders In Quality Culture Development: A Mixed Methods Study, Eshetu Mandefro, Tesfaye Semela, Ashebir Bezabhi

Higher Learning Research Communications

Objectives: In higher education institutions (HEIs), building a strong quality culture (QC) is essential to ensure the quality of education provided. QC integrates organizational, managerial, and psychological elements that shape how quality is understood and improved in HEIs. This study explores how leaders at the departmental and faculty levels navigate and contribute to quality culture development (QCD).

Methods: We employed a sequential explanatory mixed-methods design. A total of 1,029 academics completed questionnaires, and 33 leaders at the departmental and faculty levels were interviewed at three public universities in Ethiopia.

Results: The findings reveal that leadership roles at the departmental and …

Investigating Interleukin-19 And Interleukin-33 In Breast Cancer Of Iraqi Women: An Immunohistochemical Study, Fouad Najm Abed, Suhad Saad Mahmood

Baghdad Science Journal

Cytokines are immune elements that have been found as marker either for tumor-promoting or inhibiting effects on breast tumor development, depending evidently on their exact quantities as well as the existence of additional modifying variables. The study aims to evaluate the relationship between breast cancer tissue and the expression level of IL-19 and IL-33. This study includes using breast cancer tissue (30 specimens) and normal breast tissue (20 specimens) to analyze the expression level of IL-19 and IL-30. Using immunohistochemical technique, the results indicated that lL-33 and also IL-19 were strongly elevated in patients with stage II and stage III …