Digital Commons Network^™

The Path Forward For T Cell Engagers In Patients With Prostate Cancer, Sumit K. Subudhi, Bilal A. Siddiqui, Kevin K. Zarrabi, William K. Kelly, Charles G. Drake

Department of Medical Oncology Faculty Papers

T cell engagers (TCEs) recruit T cells to the tumor microenvironment (TME) to induce antitumor immune responses. TCEs have demonstrated promising clinical responses in patients with metastatic castration-resistant prostate cancer and have advanced into phase 3 clinical trials. Here we provide an overview of the mechanisms of action of TCEs, including both CD3-targeted and CD28-targeted agents, and review the clinical development of these agents for prostate cancer. We propose a path forward for TCEs in prostate cancer, in which innovative clinical trials will facilitate a biological understanding of mechanisms of efficacy and toxicity to inform: (1) development of predictive biomarkers …

Directed Neutrosophic Graph Using Morphological Operators And Its Applications, Abraham Jacob, Ramkumar P. B., Dhanya P. M

Neutrosophic Sets and Systems

No abstract provided.

An Algorithmic Approach To Bridge Detection In Bijective Neutrosophic Graph With Application In Cancer Diagnosis, D. Rajalaxmi, V. Vijaya, Said Broumi, S. Revathi

Neutrosophic Sets and Systems

No abstract provided.

Irregular Pythagorean Neutrosophic Graphs, P. Chellamani, D. Ajay

Neutrosophic Sets and Systems

No abstract provided.

Neutrosophic Sets And Systems, Vol. 96, 2026, Florentin Smarandache, Mohamed Abdel-Basset, Maikel. Leyva Vazquez

Neutrosophic Sets and Systems

No abstract provided.

Winner's Curse Free Robust Mendelian Randomization With Summary Data, Zhongming Xie, Wanheng Zhang, Jingshen Wang, Chong Wu

Faculty, Staff and Student Publications

In the past decade, the increased availability of genome-wide association studies summary data has popularized Mendelian Randomization (MR) for conducting causal inference. MR analyses, incorporating genetic variants as instrumental variables, are known for their robustness against reverse causation bias and unmeasured confounders. Nevertheless, classical MR analyses using summary data may still produce biased causal effect estimates due to the winner’s curse and pleiotropy issues. To address these two issues and establish valid causal conclusions, we propose a unified robust Mendelian Randomization framework with summary data, which systematically removes the winner’s curse and screens out invalid genetic instruments with pleiotropic effects. …

Interfacial Engineering Of Electrodes And Solid-State Electrolytes For High-Performance Lithium-Ion And Sodium-Ion Batteries, Ahmad Helaley

McKelvey School of Engineering Graduate Student Theses & Dissertations

The rapid expansion of electrified transportation and renewable energy integration demands advanced lithium-ion (Li-ion) and sodium-ion (Na-ion) batteries with enhanced safety, long-term reliability, and high energy efficiency. However, conventional systems employing liquid electrolytes continue to exhibit persistent failure modes, including thermal instability, parasitic interfacial reactions, transition-metal dissolution, and electrode degradation under high-voltage or fast-charging conditions. These limitations become even more critical in solid-state configurations, where insufficient ion mobility and interfacial incompatibility can severely restrict electrochemical performance. The first part of this dissertation develops an atomic-layer-scale interfacial stabilization strategy using atomic layer deposition (ALD) coatings. ZnO-modified graphite anodes in Li-ion cells …

Eepd1 Evolved A Unique Dna Clamping Dimer Protecting Reversed Replication Forks, Runze Shen, Altaf H Sarker, Yue Chen, Min Liu, Sunetra Roy, Andrew S Arvai, Albino Bacolla, Zamal Ahmed, Panagiotis Katsonis, Michal Hammel, Isao Kuraoka, Miaw-Sheue Tsai, Corydon Irie, Lukas Webb, Olivier Lichtarge, Chi-Lin Tsai, Susan E Tsutakawa, Katharina Schlacher, John A Tainer

Faculty, Staff and Student Publications

Exonuclease/endonuclease/phosphatase (EEP)-fold hydrolases are canonically monomeric phosphodiesterases exemplified by APE1, DNase I, and TDP2 nucleases. While EEP family domain containing protein 1 (EEPD1) acts in DNA stress responses, its proposed nuclease activities are enigmatic. Here, we integrate hybrid structural methods, evolution, biochemistry, cancer genomics, plus molecular and cell biology to define EEPD1 structure, assembly, and function at stalled DNA replication forks. Results imply EEPD1 surprisingly requires both unique EEP domain dimer and distinctive tandem Helix-hairpin-Helix [(HhH)2] domains to clamp double-stranded (ds) DNA at reversed DNA replication forks for fork protection. Small-angle X-ray Scattering (SAXS), crystal, and cryo-EM structures unveil an …

Biological Opinion Monitoring Of Riparian Habitat And Forest Stand Resources, Peter D. Howe

Funded Research Records

No abstract provided.

Correlation Between Prevalence Of Some Colibactin Genes, Biofilm Formation, And Antimicrobial Resistance In Uropathogenic E. Coli In Iraq, Rukiya Saad Jassam, Husam Sabah Auhim

Baghdad Science Journal

Colibactin is a genotoxin produced by Enterobacteriaceae via a polyketide synthase (pks) island cluster. There is less knowledge regarding the distribution of colibactin genes in E. coli isolates in Iraq and its correlation with biofilm and antibiotic susceptibility. Therefore, this study aimed to investigate the frequency of some colibactin genes (CIbA and CIbQ) in uropathogenic E. coli in Iraq and evaluate the correlation with biofilm and antimicrobial resistance. Between October 2023 and January 2024, 70 E. coli isolates were isolated from 120 females diagnosed with UTIs. Isolates were identified first by biochemical methods and confirmed molecularly by amplification …

Prevalence And Molecular Characterization Of Cytb Gene Of Pediculus Humanus Capitis In The Northern Regions Of Basrah Province, Iraq, Sarmad Awad Mozan Al-Asadi, Asmaa Abdul-Zahra Sabaa Al-Edany, Luay Al-Kanan

Baghdad Science Journal

Human head lice are widely dispersed ectoparasites in the world and have been divided into 6 haplogroups (A to F). There are no studies about the louse haplogroup type in Iraq. Thus, the study aimed to determine the species of head lice and their prevalence rate in primary school students in north Basrah and also aimed to determine the genotype and haplogroup of head lice in these regions. All louse samples belong to Pediculus humanus capitis and their prevalence rate was significantly higher in female students (34.9%) than in male students (23.2%). Molecular genotyping of the cytb gene using PCR …

Oscillation Conditions For Solutions Of First Order Piecewise Constant Neutral Differential Equations, Sora Ali Majeed, Hussain Ali Mohamad

Baghdad Science Journal

The research seeks to examine a new form of equations as well as possible criteria for oscillation and non-oscillation for all solutions of first-order neutral differential equations with the piecewise constant, whether these oscillatory solutions are convergent or non-convergent, by finding sufficient conditions that guarantee the oscillation of all solutions of these equations. According to NDEPC, these equations contain three delays and three coefficients, which requires that part of the coefficients in this equation be piecewise continuous. In witch A function that assumes constant values over predetermined intervals is known as a piecewise constant argument (PCA). The biggest integer function …

Air Pollution Assessment Around Al-Rumaila Combined Cycle Power Plant, Basrah Governorate Under Dry Climatic Conditions, Mariam S. Nasser, Monim H. Al-Jiboori, Jinan S. Al-Hassany

Baghdad Science Journal

The paper addresses the potential air pollution levels resulting from the combustion of natural gas in the Rumaila combined cycle power plant in Basrah city. The study aims to evaluate the concentrations of pollutants (carbon monoxide, sulfur dioxide, nitrogen oxides, and particulate matter) at distances of 100, 500, and 1000 meters from the plant using a Gaussian dispersion model. This includes calculating the emission rates of pollutants from the stacks and estimating atmospheric stability based on data from the Iraqi Meteorological Authority. The study also determines the Turner-Pasquill stability classes for August 2023 and the wind speed and direction at …

Characterization And Identification Of Some Indigenous Bacterial Strains For Heavy Metal Accumulation From Contaminated Soils, Aziza Usmonkulova, Gulchekhra Kadirova, Nosir Shukurov, Tulkin Shonakhunov, Samatov Nuriddin

Baghdad Science Journal

Numerous studies have reported elevated quantities of cadmium and nickel in soil, resulting in reduced plant growth, particularly in biomass, chlorophyll content, and photosynthetic traits due to their hazardous nature. Therefore, it is crucial to enhance plant resistance to heavy metal stress and reduce the toxicity of cadmium and nickel. In this study, several bacterial strains were isolated from heavy metal-contaminated soil to investigate their potential role in facilitating detrimental consequences of heavy metal stress. The capacity of the isolates to increase plant production under heavy metal stress and minimal inhibitory concentration was evaluated after the isolates were identified at …

Effect Of Cooking Methods On Lead (Pb) In Pasig River-Sourced Tilapia (Oreochromis Niloticus), Rhian Joy M. Romero, Mary Rosendahl D. Monteverde, Francesca Simone A. Remorozo, Lizel P. Bonifacio, John Albert D. Gurtiza

DLSU Senior High School Research Congress Conference Proceedings

Once declared biologically dead, the Pasig River now shows signs of aquatic life but remains heavily polluted with heavy metals like lead (Pb), which accumulate in fish and pose health risks. Despite this, many communities still rely on the river for food, particularly tilapia. This study addresses public health concerns by evaluating whether common cooking methods—frying, grilling, and steaming can reduce Pb levels in tilapia (Oreochromis niloticus) from the Pasig River to safe levels for consumption. A total of 107 tilapia samples were collected from Barangay Hulo, Mandaluyong City. The fish were cleaned, grouped, and cooked for 25 minutes using …

Tinjauan Terhadap Perkembangan Delik-Delik Khusus Masyarakat Yang Mengalami Modernisasi, Mardjono Reksodiputro, S.H., M.A.

Jurnal Hukum & Pembangunan

Abstract

Removing Race From Clinical Algorithms: History, Politics, And Medicine, David S. Jones Md, Ph.D.

History of Medicine Seminar

No abstract provided.

A (Grey)T Solution To California’S Drought, Daniel Foxhoven

Fresh Voices: Composition at Cal Poly

No abstract provided.

Want To Get Injured? Try Crossfit, Yoshito Funakoshi

Fresh Voices: Composition at Cal Poly

No abstract provided.

Catastrophes From Consumption: Meat Production Problems, Dana Bakke

Fresh Voices: Composition at Cal Poly

No abstract provided.

Everything Is Sound, Kiana Rastrou

Fresh Voices: Composition at Cal Poly

No abstract provided.

Considering David Foster Wallace’S Lobster, Valeria Salazar

Fresh Voices: Composition at Cal Poly

No abstract provided.

Sea Lion Beach, Maurice Goodman

Fresh Voices: Composition at Cal Poly

No abstract provided.

Too Smart For School, Jackie Budidharma

Fresh Voices: Composition at Cal Poly

No abstract provided.

Insulin Is Not A Cure—It’S Life Support, Alejandra Garcia

Fresh Voices: Composition at Cal Poly

No abstract provided.

Human Bone Marrow-Mesenchymal Stem Cells Differentiation Into Brain-Like Endothelial Cells, Yomna Soliman, Güli̇n Baran, Nur Mustafaoğlu

Turkish Journal of Biology

Background/aim: Brain microvascular endothelial cells (BMECs), which constitute the blood–brain barrier (BBB), are essential for maintaining central nervous system homeostasis. Like BMECs, multipotent mesenchymal stem cells (MSCs) originate from the mesodermal lineage. Thus, MSCs may serve as a direct and efficient cellular source for BMEC-like differentiation. Notably, differentiation of human induced pluripotent stem cells (hiPSCs) into BMECs typically involves a 2-step protocol: inducing mesodermal commitment followed by endothelial specification. In contrast, direct differentiation from MSCs could bypass the initial mesodermal induction step, offering a streamlined alternative. This study tested a novel strategy for differentiating MSCs into brain-like endothelial cells (BLECs), …

Non-Glycosylated, Legumain-Cleavable Isacs Drive Potent Anti-Tumor Immunotherapy Via A Bystander Effect, Anqi Zhang, Mohan Reddy Mullapudi, Lina Wu, Michele Yi, Mohammad Asikur Rahman, Aiman A. Yaseen, H Kayla Zhong, Tracy A. Brooks, L Nathan Tumey

Pharmacy Faculty Scholarship

Pancreatic ductal adenocarcinoma (PDAC) is the most lethal form of pancreatic cancer, with poor prognosis driven by late diagnosis, therapeutic resistance, and an immunosuppressive tumor microenvironment. Interactions between tumor cells and immune cells promote immune evasion and tumor progression, limiting the efficacy of immune checkpoint blockade and other immunotherapies. Given the high expression of trophoblast cell surface antigen 2 (TROP2) in PDAC, we developed a TROP2-targeted Toll-like receptor 7 (TLR7) agonist (E104) designed for selective accumulation within the tumor microenvironment to activate antitumor immunity. Although antibody bioactivity is traditionally linked to Fcγ receptor (FcγR) engagement and recruitment of effector cells, …

Dose-Dependent Ifn Programs In Myeloid Cells After Mrna And Adenovirus Covid-19 Vaccination., Giray N Eryilmaz, Yilmaz Yucehan Yazici, Radu Marches, Eleni P Mimitou, Lisa Kenyon-Pesce, Kim Handrejk, Sonia Jangra, Michael Schotsaert, Adolfo García-Sastre, George A Kuchel, Jacques Banchereau, Duygu Ucar

Faculty Research 2026

BACKGROUND. The SARS-CoV-2 pandemic provided a rare opportunity to study how human immune responses develop to a novel viral antigen delivered through different vaccine platforms. However, to date, no study has directly compared immune responses to all 3 FDA-approved COVID-19 vaccines at single-cell multiomic resolution.

METHODS. We longitudinally profiled SARS-CoV-2–naive adults (n = 31) vaccinated with BNT162b2, mRNA-1273, or Ad26.COV2.S, integrating plasma cytokines, antibody titers, and single-cell multiomic data (DOGMA-Seq).

RESULTS. We discovered a distinct, transient IFN program termed ISG-dim, which emerged specifically 1–2 days after the first mRNA dose in approximately 10% of myeloid cells. This state was …

Structure–Activity Modeling And Hybrid Machine Learning-Based Prediction Of Bioactivity In Pyrazole Derivatives For Drug Discovery Applications, Kader Şahi̇n, Serhat Kiliçarslan, Serdar Durdaği, Emi̇n Saripinar

Turkish Journal of Biology

Background/aim: Pyrazole derivatives are of growing interest due to their diverse pharmacological activities. However, their biological activity is often highly sensitive to subtle structural modifications. Existing quantitative structure–activity relationships (QSAR) approaches frequently fail to capture the conformational flexibility and nonlinear structure–activity relationships (SAR) of such heterocyclic scaffolds, creating a gap in the accurate prediction of their biological profiles. Therefore, there is a strong need for more robust and predictive computational frameworks. This study addresses this gap by integrating four-dimensional (4D)-QSAR descriptors with hybrid machine learning (ML) techniques to improve predictive accuracy and provide a more reliable tool for structure-based drug …

Synthesis, Characterization And Photodegradation Study Of Titanium Dioxide Nanoparticles Mediated Using Melon Peel Extract, Mohamed Abdelkalik Hussain, Wadhah Naji Al Sieadi

Baghdad Science Journal

The importance of nanotechnology in protecting the environment is represented in multiple applications, including, for example, the green synthesis of nanoparticles (NPs), using the remains of plant parts, as well as photolysis application that used semiconductors NPs which showed a clear effect in treating water from organic pollutants, this study combines these two applications, in terms of green synthesis of titanium dioxide nanoparticles (TiO₂NPs) using melon peel (Cucumis melo L.) in sol-gel method, as well as, the photodegradation of methylene blue dye (MB) by using a new irradiation photoreactor device which has designed and implemented for …